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Ralf Kiesslich, Stefan Schubert, Michael Mross, Tobias Klugmann, Michael Klemt-Kropp, Imke Behnken, Gillaume Bonnaud, Eric Keulen, Marcel Groenen, Michael Blaker, Thierry Ponchon, Wilfred Landry, Meredin Stoltenberg
Background and study aims  The success of any colonoscopy procedure depends upon the quality of bowel preparation. We evaluated the efficacy and safety of a new tailored dosing (TD) regimen compared with the approved PICOPREP day-before dosing regimen (DBD) in the European Union. Patient and methods  Patients (≥ 18 years) undergoing colonoscopy were randomised (2:1) to TD (Dose 1, 10 - 18 hours; Dose 2, 4 - 6 hours before colonoscopy) or DBD (Dose 1 before 8:00AM on the day before colonoscopy; Dose 2, 6 - 8 hours after Dose 1)...
April 2017: Endoscopy International Open
Isabelle D Munsterman, Eva Cleeren, Tjeerd van der Ploeg, Richard Brohet, René van der Hulst
OBJECTIVES: Adequate bowel preparation is an important step for an effective colonoscopy. Polyethylene glycol solution (Kleanprep) and sodium picosulphate with a magnesium citrate solution (Picoprep) are bowel cleansing agents registered and available for this purpose. So far, the results of studies comparing the effectiveness of bowel cleansing between the two agents are inconclusive. This may be because of differences in administration regimes and subjective measurement of bowel cleansing...
January 2015: European Journal of Gastroenterology & Hepatology
K C Fok, I B Turner, W C Teoh, R L Levy
BACKGROUND: A previous study utilising oral polyethylene-glycol by Borg et al. concluded that obesity is an independent predictor of inadequate bowel preparation at colonoscopy. AIM: To compare bowel preparation quality between obese and non-obese individuals as assessed by Boston bowel preparation scale (BBPS) after using sodium picosulphate. METHODS: Prospective recruitment of patients at a day surgical unit in a New South Wales academic hospital...
December 2012: Internal Medicine Journal
I C Lawrance, R P Willert, K Murray
BACKGROUND AND STUDY AIMS: Bowel-cleansing studies are frequently underpowered, poorly designed, and use subjective bowel cleansing assessments. Consensus on efficacy, tolerability, and preparation-induced mucosal abnormalities is lacking. This study aimed to clarify the differences in efficacy and preparation-induced mucosal inflammation of sodium phosphate (NaP), colonLYTLEY (PEG), and Picoprep (Pico). PATIENTS AND METHODS: This was a prospective randomized single-blinded trial of ambulatory patients to assess the efficacy of bowel preparation and preparation-induced mucosal inflammation...
May 2011: Endoscopy
Prasad J Athreya, Gareth N Owen, Shing W Wong, Philip R Douglas, Graham L Newstead
BACKGROUND: Colonoscopy is considered the gold standard for investigation of large bowel pathology. Numerous factors influence the efficacy of bowel preparation for colonoscopy. Inadequate bowel preparation can lead to missed pathology. Timing of fasting and bowel preparation, timing of procedure and possibly patient bowel habit and presence of diverticula may have an influence on the quality of the preparation. The aim of this study was to investigate the quality of cleansing of sodium picosulfate (Picoprep-3™, Pharmatel Fresenius Kabi Pty Ltd, Pymble, NSW, Australia) with different administration schedules and to evaluate whether patient's bowel patterns influence the quality of cleansing...
April 2011: ANZ Journal of Surgery
A J Renaut, S Raniga, F A Frizelle, R E Perry, L Guilford
OBJECTIVE: Small-volume bowel preparations for colonoscopy has become increasingly popular due to improved tolerance by patients and equivalent efficacy compared with the larger volume preparations. Comparative studies, however, between small volume preparations are lacking. This randomized controlled trial aimed at comparing the efficacy and acceptability of phospo-soda buffered saline (Fleet) with sodium picosulphate/magnesium citrate (Picoprep) in the preparation of patients for colonoscopy...
June 2008: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Joe J Tjandra, Miranda Chan, Peter P Tagkalidis
PURPOSE: Small-volume bowel preparation is better tolerated than 4-liter polyethylene glycol lavage. However, the efficacy of various small-volume bowel preparation agents for colonoscopy has not been clearly defined. This randomized, controlled trial was designed to compare oral sodium phosphate (Fleet) with Picoprep (sodium picosulfate-based preparation). METHODS: Two hundred twenty-five outpatients, aged 65 years or younger, who would undergo colonoscopy by two endoscopists were randomized to receive two bottles of oral sodium phosphate or three sachets of Picoprep...
May 2006: Diseases of the Colon and Rectum
Liu-Ming Schmidt, Pamela Williams, Denis King, Dayashan Perera
PURPOSE: Bowel preparations for colonoscopy have to balance the demand for adequate cleansing action of the bowel and patient acceptability. There has been no study comparing Picoprep-3 (sodium picosulfate), a relatively new product, to Fleet (sodium phosphate), a well-studied and widely used preparation. This study was designed to compare the efficacy and patient tolerance of these two bowel preparations for colonoscopy. METHODS: A randomized, single-blinded, prospective trial was conducted...
February 2004: Diseases of the Colon and Rectum
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