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https://www.readbyqxmd.com/read/27706008/melatonin-s-effect-on-the-efficacy-of-desmopressin-in-the-treatment-of-enuresis
#1
Pietro Ferrara, Annamaria Sbordone, Costanza Cutrona, Francesca Ianniello, Chiara Guadagno, Giacomo Perrone, Antonio Chiaretti, Alberto Verrotti, Vincenzo Di Lazzaro
PURPOSE: This study aims to evaluate and compare the efficacy of exogenous melatonin associated with desmopressin (dDAVP) and dietary recommendations. METHODS: A total of 189 patients were enrolled from the Service of Pediatrics, Campus Bio-Medico University Hospital of Rome, from January 2013 to June 2015. Of the 189 original patients, 153 children, aged between 5 and 14 years (mean age, 8.7 years) were included in the study. After clinical evaluation and a 3-month period of observation without treatment, children were assigned to receive treatment in one of 3 groups: group 1, dDAVP at a dose of 120 mcg a day (Minirin); group 2, dDAVP at a dose of 120 mcg and dietary recommendations; or group 3, dDAVP at a dose of 120 mcg, dietary recommendations, and melatonin at a dose of 1 mg a day (Melamil plus)...
September 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27213601/-hypernatremia-diagnostics-and-therapy
#2
Christian Arndt, Hinnerk Wulf
Hypernatremia is a common electrolyte disorder that reflects an imbalance in the water balance of the body, often resulting from an increased loss of free water compared to sodium excretion. It is rarely based on excessive sodium intake. The clinical presentation is often characterized by a central nervous system dysfunction (confusion, coma) and pronounced thirst (in awake patients). In addition to medical history, the volume status of the patient and the osmolality of urine are leading in the differential diagnosis...
May 2016: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/27172867/diabetes-insipidus-and-pregnancy
#3
Philippe Chanson, Sylvie Salenave
Diabetes insipidus (DI) is a rare complication of pregnancy. It is usually transient, being due to increased placental production of vasopressinase that inactivates circulating vasopressin. Gestational, transient DI occurs late in pregnancy and disappears few days after delivery. Acquired central DI can also occur during pregnancy, for example in a patient with hypophysitis or neuroinfundibulitis during late pregnancy or postpartum. Finally, pre-existing central or nephrogenic DI may occasionally be unmasked by pregnancy...
June 2016: Annales D'endocrinologie
https://www.readbyqxmd.com/read/26676309/sublingual-desmopressin-is-efficient-and-safe-in-the-therapy-of-lithiasic-renal-colic
#4
Catalin Pricop, Dumitru D Branisteanu, Martha Orsolya, Dragos Puia, Anca Matei, Ionel Alexandru Checherita
PURPOSE: To evaluate the effects of newer sublingual desmopressin administration in lithiasic renal colic, alone or combined with a nonsteroidal anti-inflammatory drug (NSAID). METHODS: Prospective single-blind study including an initial number of 249 patients with lithiasic renal colic was randomized as follows: group NSAID (71 patients) received ketorolac tromethamine (ketorolac) 30 mg im and sublingual placebo (vitamin C), groups D1 and D2 (57 and 62 patients) received sublingual desmopressin (Minirin Melt), 60 and 120 μg, respectively, whereas group C (59 patients) received a combination of 30 mg im ketorolac and 60 μg sublingual desmopressin...
February 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/26006173/surgical-outcomes-of-the-endoscopic-transsphenoidal-route-to-pituitary-tumours-in-paediatric-patients-10-years-of-age-5-years-of-experience-at-a-single-institute
#5
Rucai Zhan, Guangming Xu, Timothy M Wiebe, Xingang Li
OBJECTIVE: To evaluate the safety and effectiveness of the endoscopic endonasal transsphenoidal approach (EETA) for the management of pituitary adenomas in paediatric patients >10 years of age. METHODS: A retrospective chart review was performed to identify 56 paediatric patients between 10 and 18 years of age who underwent an endonasal endoscopic transsphenoidal approach for the resection of a pituitary adenoma during the last 5 years. The age, sex, symptoms, tumour size, extent of tumour resection, clinical outcome and surgical complications of patients were reviewed...
August 2015: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/25745483/desmopressin-lyophilisate-for-the-treatment-of-central-diabetes-insipidus-first-experience-in-very-young-infants
#6
Kathleen De Waele, Martine Cools, Ann De Guchtenaere, Johan Van de Walle, Ann Raes, Sara Van Aken, Kris De Coen, Piet Vanhaesebrouck, Jean De Schepper
INTRODUCTION: In neonates and small infants, early diagnosis of central diabetes insipidus (CDI) and treatment with desmopressin in low doses (avoiding severe hypo- or hypernatremia) are important to prevent associated high morbidity and mortality in this particular age group. CASE PRESENTATION: We described pharmacokinetic and pharmacodynamic results of the use of recently launched oral desmopressin lyophilisate (Minirin Melt®) in two infants with CDI, diagnosed at the age of 12 and 62 days, respectively...
October 2014: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/24360179/-significance-of-pseudocapsule-in-the-excision-of-pituitary-adenomas-in-transsphenoidal-surgery
#7
Ming Feng, Yong Yao, Kan Deng, Bing Xing, Wei Lian, Gui-lin Li, Jun-ji Wei, Wan-chen Dou, Xin-jie Bao, Xiao-hai Liu, Cong-xin Dai, Jun Gao, Yu Wang, Wen-bin Ma, Yi Yang, Ding-rong Zhong, Ren-zhi Wang
OBJECTIVE: To explore the significance of pseudocapsule in the excision of pituitary adenomas in transsphenoidal surgery. METHODS: For 22 patients with pituitary adenomas over a period of 2 years at Peking Union Medical College Hospital, resection of pseudocapsule was applied for complete tumor removal. Pituitary function test and radiological imaging were performed at pre-operation, 3 months post-operation and at subsequent 6-12 months intervals postoperatively...
September 17, 2013: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/24217636/-craniopharyngioma-in-children-importance-of-a-multidisciplinary-approach-and-therapeutic-strategies-in-the-treatment-of-relapsing
#8
C M M Fiorito, E Giglione, S Bellone, P Peretta, D Bertin, M E Basso, G Bona
The craniopharyngioma is a benign intracranial nonglial tumor derived from a malformation of the embryonic tissue. Represents approximately 6-9% of brain tumors in children. It grows close to the optic nerve, hypothalamus and pituitary. The most frequent histological variety in children is adamantinomatous. The initial symptoms of intracranial hypertension is headache and nausea, followed by visual disturbances, impaired hormonal changes such as the secretion of GH, gonadotropins, TSH and ACTH and central diabetes insipidus...
December 2013: Minerva Pediatrica
https://www.readbyqxmd.com/read/23644438/severe-water-intoxication-secondary-to-the-concomitant-intake-of-non-steroidal-anti-inflammatory-drugs-and-desmopressin-a-case-report-and-review-of-the-literature
#9
Elisa Verrua, Giovanna Mantovani, Emanuele Ferrante, Andrea Noto, Elisa Sala, Elena Malchiodi, Gaetano Iapichino, Paolo Beck Peccoz, Anna Spada
Most of the clinical data on the safety profile of desmopressin (DDAVP), which is an effective treatment for both polyuric conditions and bleeding disorders, originate from studies on the tailoring of drug treatment, whereas few reports exist describing severe side effects secondary to drug-drug interaction. We herein describe a case of severe hyponatremia complicated by seizure and coma due to the intake of non-steroidal anti-inflammatory drugs (NSAIDs) in a patient on DDAVP replacement therapy for central diabetes insipidus (DI)...
January 2013: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/23624139/severe-water-intoxication-secondary-to-the-concomitant-intake-of-non-steroidal-anti-inflammatory-drugs-and-desmopressin-a-case-report-and-review-of-the-literature
#10
REVIEW
Elisa Verrua, Giovanna Mantovani, Emanuele Ferrante, Andrea Noto, Elisa Sala, Elena Malchiodi, Gaetano Iapichino, Paolo Beck Peccoz, Anna Spada
Most of the clinical data on the safety profile of desmopressin (DDAVP), which is an effective treatment for both polyuric conditions and bleeding disorders, originate from studies on the tailoring of drug treatment, whereas few reports exist describing severe side effects secondary to drug-drug interaction. We herein describe a case of severe hyponatremia complicated by seizure and coma due to the intake of non-steroidal anti-inflammatory drugs (NSAIDs) in a patient on DDAVP replacement therapy for central diabetes insipidus (DI)...
January 2013: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/23470483/-pharmacological-and-clinical-profile-of-desmopressin-acetate-hydrate-minirin-melt-%C3%A2
#11
REVIEW
Mikiko Hayashi
No abstract text is available yet for this article.
March 2013: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
https://www.readbyqxmd.com/read/22057258/-desmopressin-parenteral-in-patients-with-vwd1-vwd-2a-and-thrombocytopathy
#12
B Siegmund, H Pollmann
UNLABELLED: Desmopressin (DDAVP, Minirin® parenteral), which induces the release of von-Willebrand factor from endogenous stores, is indicated in von Willebrand disease type 1 (VWD 1). In the present study effectiveness of DDAVP was tested and side effects were recorded in patients with VWD 1, von Willebrand disease type 2 (VWD 2) or thrombocytopathy (TCP). PATIENTS, METHODS: Subjects were analysed prior to and after Minirin parenteral infusion (0.4 μg/kg body weight (b...
November 2011: Hämostaseologie
https://www.readbyqxmd.com/read/21626284/desmopressin-duration-of-antidiuretic-action-in-patients-with-central-diabetes-insipidus
#13
RANDOMIZED CONTROLLED TRIAL
Kristian Vinter Juul, Daniel G Bichet, Jens Peter Nørgaard
The key question answered by this study is whether it is possible to deliver a pharmacokinetic and pharmacodynamic duration of antidiuretic action long enough to ensure adequate antidiuresis with two daily administrations of desmopressin in patients with central diabetes insipidus (CDI). We studied the efficacy and safety of desmopressin i.v. in 13 CDI patients using two 3-way crossover designs, in the doses 30, 60, 125 ng, and 125, 250 and 500 ng. Duration of action, minimum output rate, max osmolality and average osmolality during action (AUC osmolality) were measured every 30 min for the first 2 h during the infusion, and then every hour or every second hour until the urine output rate was greater than 2 ml/kg/30 min...
August 2011: Endocrine
https://www.readbyqxmd.com/read/20141740/-effects-of-yiniao-recipe-on-serum-antidiuretic-hormone-level-and-plasma-ratio-of-camp-to-cgmp-in-rats-with-kidney-yang-deficiency
#14
Wen Su, Ai-xia Hu, Heng DU, Kai Yuan, Hui-fu Xu
OBJECTIVE: To investigate the effects of Yiniao Recipe, a compound traditional Chinese herbal medicine, on contents of serum antidiuretic hormone, and plasma cyclic adenosine monophosphate and cyclic guanosine monophosphate in rats with kidney-yang deficiency. METHODS: Forty male Wistar rats were randomly divided into blank control group, untreated group, desmopressin (Minirin) group, low-dose Yiniao Recipe group and high-dose Yiniao Recipe group, with 8 rats in each group...
February 2010: Zhong Xi Yi Jie He Xue Bao, Journal of Chinese Integrative Medicine
https://www.readbyqxmd.com/read/20135596/-desmopressin-minirin-in-multiple-trauma-a-case-report
#15
P Hilbert, M F Struck, R Stuttmann
Bleeding and clotting disturbances are not uncommon in trauma patients and require an early and consequent therapy. Under the prevalent pathophysiological circumstances of hypothermia, acidosis and clotting disturbances, desmopressin seems to be a possible option to control diffuse bleeding. We report about 2 trauma patients with diffuse bleeding and in whom desmopressin was used successfully to control bleeding from the point of view of the authors. We discuss the advantages and disadvantages of desmopressin in the 2 patients...
May 2010: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/19777917/-germinoma-responsible-for-central-diabetes-insipidus
#16
N Bakoto, M Strivay
We report the case of a 20-year-old woman who presented with sudden onset of polydipsia and polyuria. A diagnosis of diabetes insipidus was confirmed and the MRI showed a pituitary stalk enlargement. The patient was treated with Minirin. Two years later, she developed a panhypopituitarism. The MRI showed an intrasellar mass with an enlargement of the pituitary gland. A biopsy confirmed a germinoma. The patient was treated with radiotherapy with a partial response as only a part of the mass disappeared. This case highlights the importance of the clinical and radiological follow-up of central diabetes insipidus, especially when it is of unknown origin...
July 2009: Revue Médicale de Liège
https://www.readbyqxmd.com/read/19080279/postoperative-pituitary-hormonal-disturbances-and-hormone-replacement-therapy-time-and-dosage-in-children-with-craniopharyngiomas
#17
Gui-mei Li, Xiao-jun Sun, Peng Shao
BACKGROUND: The proliferative activity and penetration into the hypothalamic structures in children craniopharyngiomas (CP) often make radical resection difficult. Therefore, complete resection of CP often results in permanent multiple pituitary hormone deficiency (MPHD). This study aimed to elucidate the postoperative pituitary hormonal disturbances, and hormone replacement therapy (HRT) time and dosage in children with CP. METHODS: Twenty patients with growth retardation and CP after resection, comprising 14 boys and 6 girls, with a mean age of (10...
October 20, 2008: Chinese Medical Journal
https://www.readbyqxmd.com/read/18277371/-germinoma-a-rare-cerebral-tumor-causing-central-diabetes-insipidus-in-childhood
#18
F Zanetta, G Di Dio, S Savastio, A Saccagno, A Petri, S Bellone, M Maghnie, G Bona
Germinoma represents 7.8% of cerebral tumors in pediatric age and 50-65% of germ cell cerebral tumors. Generally it is a definite lesion of the pineal gland or suprasellar region, frequently occurring in the first three decades of life. Clinical presentation depends on tumor localization. Pineal lesions generally determine symptoms due to the compression of cerebral structures, causing Parinaud syndrome, while hypothalamic lesions are often characterized by diabetes insipidus, hypopituitarism and visual defects...
February 2008: Minerva Pediatrica
https://www.readbyqxmd.com/read/18080519/-operative-neurosurgery-personal-view-and-historical-backgrounds-4-selective-amygdalohippocampectomy-sahe
#19
Yasuhiro Yonekawa
Selective amygdalohippocampectomy SAHE has been pioneered by Yasargil et al in the mid 1970 within the scope of surgical treatment for intractable mesial temporal lobe epilepsy MTLE. In this article, the author has emphasized microsurgical points to be kept in mind in carrying out the procedure from the experience of just more than 200 surgeries performed by himself during the last 14 years. Historical backgrounds of development of this technique, necessary topographic anatomy, perioperative management and our results were also presented...
December 2007: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/17978791/-polyuria-and-polydipsia-in-a-5-year-old-child-diagnostic-problems
#20
G Di Dio, F Zanetta, S Zanetta, A Petri, S Bellone, G Bona
Polyuria and polydipsia could be present in three groups of diseases; polydipsia psicogena characterized by an excessive water intake, central diabetes insipidus (CDI) with a defect in the production of AVP and nephrogenic diabetes insipidus in which a defect in the renal response to vasopressin is present. In particular, CDI can be caused by lesions like germinoma and craniopharyngioma, Langerhans'cell histiocytosis, inflammatory, autoimmune and vascular diseases, trauma resulting from surgery or an accident; and in rare cases, genetic defects in the synthesis of vasopressin that are inherited as autosomal dominant or X-linked recessive traits...
December 2007: Minerva Pediatrica
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