Niranjan Meher, Gary W Ashley, Kondapa Naidu Bobba, Anju Wadhwa, Anil P Bidkar, Chandrashekhar Dasari, Changhua Mu, Ramya Ambur Sankaranarayanan, Juan A Camara Serrano, Athira Raveendran, David P Bulkley, Rahul Aggarwal, Nancy Y Greenland, Adam Oskowitz, David M Wilson, Youngho Seo, Daniel V Santi, Henry F VanBrocklin, Robert R Flavell
BACKGROUND: The uptake of large (>10 nm) non-targeted nanocarriers by bulk tumors is thought to be dominated by passive extravasation through porous tumor vessels and limited lymphatic drainage, the enhanced permeability and retention (EPR) effect. Prior studies demonstrated radiolabeled tumor-targeted and non-targeted 4-arm 40 kDa star polyethylene glycol (StarPEG) polymers for cancer imaging. By adding small molecule ligands targeting prostate-specific membrane antigen (PSMA) to the StarPEG polymer, marked increase in tumor uptake, penetration and retention in the tumor core was observed...
May 3, 2024: Advanced Healthcare Materials