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SPECT—MPI

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https://www.readbyqxmd.com/read/28086986/radioiodine-sinus-uptake-related-to-mucosal-thickening-or-aspergilloma-a-case-series-of-an-unrecognized-event-well-evidenced-by-spect-ct
#1
Renaud Ciappuccini, David Blanchard, Jean-Pierre Rame, Dominique de Raucourt, Emmanuel Babin, Stéphane Bardet
BACKGROUND: False-positive radioiodine (RAI) uptake related to chronic sinusitis and mucocele has only rarely been reported in patients with differentiated thyroid cancer (DTC) even with the recent use of single photon emission tomography with computed tomography (SPECT/CT) acquisition. No other etiology of sinus RAI uptake has been mentioned to date. OBJECTIVES: We report five cases of DTC patients with sinus RAI uptake on post-RAI scintigraphy. SPECT/CT clearly localized RAI uptake either in the sphenoid, the maxillary or the frontal sinus and highly suspected mucosal thickening in four patients and sinus aspergilloma in one patient...
January 13, 2017: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/28079797/case-report-rapid-improvement-of-crossed-cerebellar-diaschisis-after-intravascular-laser-irradiation-of-blood-in-a-case-of-stroke
#2
Wan-Hua Yang, Shiou-Ping Lin, Shin-Tsu Chang
RATIONALE: Crossed cerebellar diaschisis (CCD) is a poor prognostic factor after stroke because without immediate cerebral reperfusion no further improvements in the patient's condition can be achieved. We investigated the clinical effects of intravascular laser irradiation therapy (ILIB) on CCD and evaluated the therapeutic effect in the sub-acute post-stroke stage. PATIENT CONCERNS: The 77-year-old male with cerebral infarction in the territory of the right anterior cerebral artery only underwent conservative treatment including hydration and aspirin in the acute post-stroke stage...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28079571/spontaneous-intracranial-hypotension-with-site-of-leak-detected-only-after-111in-dtpa-cisternogram
#3
Sana Parsian, Manuela C Matesan, Sachin Shivaji Kumbhar, David H Lewis
A 54-year-old man with a 3-week history of orthostatic headache and acute on chronic subdural hematoma presented with imaging findings suggestive of spontaneous intracranial hypotension. Three myelograms were negative for leak, and nontargeted epidural blood patches did not result in symptom relief. A cerebrospinal fluid leak study using In-DTPA with SPECT/CT demonstrated a focal area of asymmetric activity at the left C2 nerve root. A left C2 root tie-off, targeted epidural blood patch, and Dura seal glue resulted in resolution of patient symptomatology highlighting the importance of fused SPECT/CT images in detection of an occult cerebral spinal fluid leak...
January 10, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28079471/pre-implant-modeling-of-depth-lead-placement-in-white-matter-for-maximizing-the-extent-of-cortical-activation-during-direct-neurostimulation-therapy
#4
Leopoldo Cendejas Zaragoza, Richard W Byrne, Marvin A Rossi
INTRODUCTION: The objective of this work was to predict preoperatively the maximum extent to which direct stimulation therapy can propagate through an epileptic circuit for stabilizing refractory focal-onset epilepsy. A pre-surgical workflow is presented which comprises a computationally intensive process for calculating the volume of cortical activation (VOCA) surrounding cylindrical depth contacts virtually placed in white matter. The process employs an activation function (AF) derived from cable modeling of an axon...
January 12, 2017: Neurological Research
https://www.readbyqxmd.com/read/28076008/pictorial-review-of-false-positive-results-on-radioiodine-scintigrams-of-patients-with-differentiated-thyroid-cancer
#5
Amy V Chudgar, Jagruti C Shah
Radioiodine has served an important role in the diagnostic workup and treatment of patients with differentiated thyroid cancer for more than 6 decades. The interpretation of radioiodine scintigraphic studies should be performed in conjunction with a comprehensive history, histopathologic correlation, and pertinent laboratory values, as well as correlation with available anatomic images and the findings from physical examination. A thorough understanding of the physiology and biodistribution of radioiodine is critical when interpreting radioiodine scintigraphic studies to avoid misinterpretation of physiologic and nonthyroid pathologic variants as thyroid cancer metastases...
January 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28073096/high-density-scalp-eeg-in-frontal-lobe-epilepsy
#6
Anteneh M Feyissa, Jeffrey W Britton, Jamie Van Gompel, Terrance L Lagerlund, Elson So, Lilly C Wong-Kisiel, Gregory C Cascino, Benjamin H Brinkman, Cindy L Nelson, Robert Watson, Gregory A Worrell
PURPOSE: Localization of seizures in frontal lobe epilepsy using the 10-20 system scalp EEG is often challenging because neocortical seizure can spread rapidly, significant muscle artifact, and the suboptimal spatial resolution for seizure generators involving mesial frontal lobe cortex. Our aim in this study was to determine the value of visual interpretation of 76 channel high density EEG (hdEEG) monitoring (10-10 system) in patients with suspected frontal lobe epilepsy, and to evaluate concordance with MRI, subtraction ictal SPECT co-registered to MRI (SISCOM), conventional EEG, and intracranial EEG (iEEG)...
January 2, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28072625/evaluation-of-a-large-renal-mass-using-99mtc-mibi-spect-ct-in-a-patient-with-chronic-kidney-disease
#7
Steven P Rowe, Michael A Gorin, Mehrbod S Javadi, Mohamad E Allaf
The differentiation of benign and indolent renal masses from aggressive tumor histologies cannot be reliably performed by CT or MRI. Additionally, renal mass biopsy risks complications and has a nondiagnostic rate of 10% to 20%. Tc-MIBI SPECT/CT has been shown to allow for the accurate differentiation of benign renal oncocytomas and hybrid oncocytic/chormophobe tumors from other more aggressive renal tumor types. We present the case of an 84-year-old man with chronic kidney disease and an 11.2-cm renal mass...
January 9, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28072619/radio-guided-lymph-node-mapping-in-bladder-cancer-using-spect-ct-and-intraoperative-%C3%AE-probe-methods-reply
#8
Wojciech Połom, Agnieszka Gruszecka, Marcin Markuszewski, Wojciech Cytawa, Piotr Lass, Marcin Matuszewski
No abstract text is available yet for this article.
January 9, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28071601/applications-of-nuclear-physics
#9
A C Hayes
Today the applications of nuclear physics span a very broad range of topics and fields. This review discusses a number of aspects of these applications, including selected topics and concepts in nuclear reactor physics, nuclear fusion, nuclear non-proliferation, nuclear-geophysics, and nuclear medicine. The review begins with a historic summary of the early years in applied nuclear physics, with an emphasis on the huge developments that took place around the time of World War II, and that underlie the physics involved in designs of nuclear explosions, controlled nuclear energy, and nuclear fusion...
February 2017: Reports on Progress in Physics
https://www.readbyqxmd.com/read/28070037/-bm-mscs-from-wuzhishan-mini-pigs-delay-the-progress-of-renal-fibrosis-induced-by-chronic-kidney-disease-through-%C3%A2-autocrine-hepatocyte-growth-factor-in-vitro
#10
Yang Xiang, Jiale Long, Jiansheng Xing, Yuanhui Gao, Qing Cheng, Yong Cai, Zhenxiang Liu, Shufang Zhang, Lie Chen, Chao Yang, Zhiming Bai
To isolate bone marrow mesenchymal stem cells (BM-MSCs) and establish the model of chronic kidney disease (CKD) of Wuzhishan (WZS) mini-pig, and to study the repairment effect of BM-MSCs on CKD-induced renal fibrosis in vitro.
 Methods: Density gradient method was used to isolate and culture BM-MSCs. The cells were verified by morphology, phenotype, differentiation and so on. The left partial ureteral obstruction (LPUUO) was used to establish the CKD model, which was evaluated by B-ultrasound, single-photon emission computed tomography (SPECT), HE and Masson staining...
December 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28068866/cognitive-abnormalities-and-cerebral-perfusion-defects-in-a-community-dwelling-cohort-of-elderly-men-with-mmse-within-the-normal-range
#11
Lena André-Petersson, Ola Thorsson, Arkadiusz Siennicki-Lantz
OBJECTIVES: Mini Mental State Examination's (MMSE's) sensitivity in its upper level is questioned, hence we investigated cognitive abnormalities and defects in regional cerebral blood flow (rCBF) in elderly with MMSE scores ≥24. METHODS: One hundred and four men at age 81 with MMSE scores ≥24 (mean 28.4 ± 1.7), no dementia or stroke, were examined with neuropsychological test battery, and their rCBF was estimated using (99mTc)-HMPAO SPECT. RESULTS: MMSE was very sparsely correlated with rCBF...
January 9, 2017: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
https://www.readbyqxmd.com/read/28067149/navigation-assisted-trans-inferotemporal-cortex-selective-amygdalohippocampectomy-for-mesial-temporal-lobe-epilepsy-preserving-the-temporal-stem
#12
Haruhiko Kishima, Amami Kato, Satoru Oshino, Naoki Tani, Tomoyuki Maruo, Hui Ming Khoo, Takufumi Yanagisawa, Kotaro Edakawa, Maki Kobayashi, Masataka Tanaka, Koichi Hosomi, Masayuki Hirata, Toshiki Yoshimine
OBJECTIVE: Selective amygdalohippocampectomy (SAH) can be used to obtain satisfactory seizure control in patients with mesial temporal lobe epilepsy (MTLE). Several SAH procedures have been reported to achieve satisfactory outcomes for seizure control, but none yield fully satisfactory outcomes for memory function. We hypothesized that preserving the temporal stem might play an important role. To preserve the temporal stem, we developed a minimally invasive surgical procedure, 'neuronavigation-assisted trans-inferotemporal cortex SAH' (TITC-SAH)...
January 9, 2017: Neurological Research
https://www.readbyqxmd.com/read/28063068/accuracy-of-177-lu-activity-quantification-in-spect-imaging-a-phantom-study
#13
Carlos F Uribe, Pedro L Esquinas, Jesse Tanguay, Marjorie Gonzalez, Emilie Gaudin, Jean-Mathieu Beauregard, Anna Celler
BACKGROUND: The aim of the study is to assess accuracy of activity quantification of (177)Lu studies performed according to recommendations provided by the committee on Medical Internal Radiation Dose (MIRD) pamphlets 23 and 26. The performances of two scatter correction and three segmentation methods were compared. Additionally, the accuracy of tomographic and planar methods for determination of the camera normalization factor (CNF) was evaluated. Eight phantoms containing inserts of different sizes and shapes placed in air, water, and radioactive background were scanned using a Siemens SymbiaT SPECT/CT camera...
December 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/28059906/re-precise-localization-of-occult-gastrointestinal-hemorrhage-using-dynamic-spect-ct
#14
Byeong-Cheol Ahn
No abstract text is available yet for this article.
February 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28058659/three-minute-spect-ct-is-sufficient-for-the-assessment-of-bone-metastasis-as-add-on-to-planar-bone-scintigraphy-prospective-head-to-head-comparison-to-11-min-spect-ct
#15
Helle D Zacho, José A Biurrun Manresa, Ramune Aleksyniene, June A Ejlersen, Joan Fledelius, Henrik Bertelsen, Lars J Petersen
BACKGROUND: The aim of this study is to assess whether ultra-fast acquisition SPECT/CT (UF-SPECT/CT) can replace standard SPECT/CT (std-SPECT/CT) as "add-on" to whole-body bone scintigraphy (WB-BS) for the investigation of bone metastases. Consecutive cancer patients referred for WB-BS who underwent SPECT/CT in addition to WB-BS were included. Std-SPECT, UF-SPECT, and low-dose CT were performed (std-SPECT: matrix 128 × 128, zoom factor 1, 20 s/view, 32 views; UF-SPECT: identical parameters except for 10 s/view and 16 views, reducing the acquisition time from 11 to 3 min)...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28058462/imaging-the-dna-damage-response-with-pet-and-spect
#16
REVIEW
James C Knight, Sofia Koustoulidou, Bart Cornelissen
DNA integrity is constantly challenged by endogenous and exogenous factors that can alter the DNA sequence, leading to mutagenesis, aberrant transcriptional activity, and cytotoxicity. Left unrepaired, damaged DNA can ultimately lead to the development of cancer. To overcome this threat, a series of complex mechanisms collectively known as the DNA damage response (DDR) are able to detect the various types of DNA damage that can occur and stimulate the appropriate repair process. Each DNA damage repair pathway leads to the recruitment, upregulation, or activation of specific proteins within the nucleus, which, in some cases, can represent attractive targets for molecular imaging...
January 5, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28056732/development-of-a-radiolabeled-amlodipine-analog-for-l-type-calcium-channel-imaging
#17
Tahereh Firouzyar, Amir Reza Jalilian, Mohammad Reza Aboudzadeh, Hossein Sadeghpour, Mehrban Pooladi, Mahdi Shafiee-Ardestani, Ali Khalaj
PURPOSE: The non-invasive imaging and quantification of L-type calcium channels in living tissues is of great interest in diagnosis of congestive heart failure, myocardial hypertrophy, irritable bowel syndrome etc. METHODS: Technetium-<sup>99m</sup> labeled amlodipine conjugate ([<sup>99m</sup>Tc]-DTPA-AMLO) was prepared starting freshly eluted (<1 h) <sup>99m</sup>Technetium pertechnetate (86.5 MBq) and conjugated DTPA-AMLO at pH 5 in 30 min at room temperature in high radiochemical purity (>99%, RTLC; specific activity: 55-60 GBq/mmol)...
January 4, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28055829/validation-of-a-multimodality-flow-phantom-and-its-application-for-assessment-of-dynamic-spect-and-pet-technologies
#18
Hanif Gabrani-Juma, Owen J Clarkin, Amir Pourmoghaddas, Brandon Driscoll, R Glenn Wells, Robert A deKemp, Ran Klein
Simple and robust techniques are lacking to assess performance of flow quantification using dynamic imaging. We therefore developed a method to qualify flow quantification technologies using a physical compartment exchange phantom and image analysis tool. We validate and demonstrate utility of this method using dynamic PET and SPECT. Dynamic image sequences were acquired on two PET/CT and a cardiac dedicated SPECT (with and without attenuation and scatter corrections) systems. A two-compartment exchange model was fit to image derived time-activity curves to quantify flow rates...
January 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28054521/samarium-153-4-bis-phosphonomethyl-carbamoyl-methyl-7-10-bis-carboxymethyl-1-4-7-10-tetraazacyclododec-1-yl-acetic-acid-a-novel-agent-for-bone-pain-palliation-therapy
#19
Hassan Yousefnia, Razieh Enayati, Mohammad Hosntalab, Samaneh Zolghadri, Ali Bahrami-Samani
AIM: Various phosphonate ligands labeled with β--emitting radionuclides have shown good efficacy for bone pain palliation. In this study, a new agent for bone pain palliation has been developed. MATERIALS AND METHODS: Samarium-153-(4-[((bis(phosphonomethyl))carbamoyl)methyl]-7,10-bis (carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl) acetic acid (153Sm-BPAMD) complex was prepared using BPAMD ligand and samarium-153 chloride. The effect of various parameters on the labeling yield of 153Sm-BPAMD including ligand concentration, pH, temperature, and reaction time were studied...
July 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28054182/takotsubo-cardiomyopathy-fdg-myocardial-uptake-pattern-in-fasting-patients-comparison-of-pet-ct-spect-and-echo-results
#20
Malgorzata Kobylecka, Monika Budnik, Janusz Kochanowski, Radoslaw Piatkowski, Marek Chojnowski, Katarzyna Fronczewska-Wieniawska, Tomasz Mazurek, Joanna Maczewska, Michał Peller, Grzegorz Opolski, Leszek Krolicki
BACKGROUND: The aim of this study was to assess the accumulation pattern of 18F-FDG in fasting patients with takotsubo cardiomyopathy (TTC) and to correlate the results with perfusion scintigraphy and echocardiography. METHODS: 18 consecutive patients with TTC were identified by clinical symptoms, cardiac catheterization, and echocardiography. Coronary angiography (CA) and transthoracic echocardiography (TTE) were performed on the day of the onset of symptoms. An assessment of myocardial perfusion (99mTc-MIBI) and glucose metabolism (18F-FDG) was performed within 18 days...
January 4, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
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