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I Lindgren, M Bååth, K Uvebrant, A Dejmek, L Kjaer, E Henic, M Bungum, L Bungum, C Cilio, I Leijonhufvud, S Skouby, C Yding Andersen, Y Lundberg Giwercman
STUDY QUESTION: Can gonadotrophin receptor variants separately or in combination, be used for the prediction of pregnancy chances in in vitro fertilization (IVF) trials? SUMMARY ANSWER: The luteinizing hormone/human chorionic gonadotrophin receptor (LHCGR) variant N312S and the follicle-stimulating hormone receptor (FSHR) variant N680S can be utilized for the prediction of pregnancy chances in women undergoing IVF. WHAT IS KNOWN ALREADY: The FSHR N680S polymorphism has been shown to affect the ovarian response in response to gonadotrophin treatment, while no information is currently available regarding variants of the LHCGR in this context...
March 2016: Human Reproduction
Jessica Lefebvre, Roland Antaki, Isaac-Jacques Kadoch, Nicola L Dean, Camille Sylvestre, François Bissonnette, Joanne Benoit, Sylvain Ménard, Louise Lapensée
OBJECTIVE: To compare the outcomes of controlled ovarian stimulation/in vitro fertilization cycles using 450 IU and 600 IU gonadotropin per day in women at risk of poor ovarian response. DESIGN: Prospective randomized controlled nonblinded study. SETTING: University-affiliated private IVF center. PATIENT(S): Women considered to be at risk of poor ovarian response: aged <41 years with basal FSH >10 IU/L, antimüllerian hormone <1 ng/mL, antral follicle count ≤ 8, or a previous IVF cycle with ≥ 300 IU/d gonadotropin that resulted in a cancellation, <8 follicles, or <5 oocytes...
December 2015: Fertility and Sterility
Alberto Revelli, Grazia Pettinau, Gemma Basso, Andrea Carosso, Alessandro Ferrero, Cecilia Dallan, Stefano Canosa, Gianluca Gennarelli, Daniela Guidetti, Claudia Filippini, Chiara Benedetto
BACKGROUND: The association of recombinant FSH (rFSH) plus recombinant LH (rLH) is currently used for Controlled Ovarian Stimulation (COS) in human IVF, but its efficacy has, to date, not yet been compared to that of human Menopausal Gonadotropin (hMG), the FSH + LH activity-containing urinary drug. METHODS: Eight hundred forty-eight (848) IVF patients classified as expected "poor" or "normal" responders according to antral follicle count (AFC) and basal (day 3) FSH were treated with rFSH + rLH (2:1 ratio, n = 398, Group A) or hMG (n = 450, Group B)...
2015: Reproductive Biology and Endocrinology: RB&E
A A Rouzi, M H Qari, M S M Ardawi
OBJECTIVE: Severe factor V (FV) deficiency is rare. There are case reports describing pregnancy outcomes in women with FV deficiency and one case report of successful pregnancy following the use of fresh frozen plasma (FFP) in several cycles of ovulation induction and intrauterine insemination and at delivery. The authors report another case to support the use of FFP for reproduction. CASE: A 27-year-old woman with severe FV deficiency was given FFP at the time of ovulation induced with clomiphene citrate, human menopausal gonadotropin (hMG), and human chorionic gonadotropin...
2015: Clinical and Experimental Obstetrics & Gynecology
Xiuxian Zhu, Xiaole Zhang, Yonglun Fu
A major cause of cycle cancellation during controlled ovarian hyperstimulation (COH) in women undergoing in vitro fertilization (IVF) is the occurrence of premature luteinizing hormone (LH) surges. Steroidal preparations can modulate the secretion of gonadotropins (Gn); however, few studies using progesterone to inhibit the premature LH surges in COH have been published. The purpose of the study was to evaluate the oral delivery of progesterone soft capsules (Utrogestan) to prevent LH surges from the follicular phase and to compare cycle characteristics as well as to evaluate pregnancy outcomes in subsequent frozen-thawed embryo transfer (FET) cycles...
May 2015: Medicine (Baltimore)
Juan Carlos Barros-Delgadillo, Cirenia Iveth Ruiz-Balderrama, Mauricio Ríos-Barba
BACKGROUND: With the use of new protocols Controlled ovarian hyperstimulation (COH) with lower doses of gonadotropins to the classics protocols and current trend of fewer embryos transferred, there is no agreement until today on the optimal dose start of a COH protocol. OBJECTIVE: Compare the results of two flexible protocols of HOC with different starting doses (150 vs 225 lU rFSH/hMG) plus a GnRH antagonist in cycles of IVF / ICSI. METHODS: Retrospective, descriptive study, we analyzed 231 cycles of IVF/ICSI being the primary variables: total FSH dose, dose increase, retrieved oocytes, embryos available for transfer and for cryopreservation...
January 2015: Ginecología y Obstetricia de México
Krzysztof Lukaszuk, Joanna Liss, Michal Kunicki, Waldemar Kuczynski, Ewa Pastuszek, Grzegorz Jakiel, Lukasz Plociennik, Krzysztof Zielinski, Judyta Zabielska
The strategy of in vitro fertilization (IVF) procedures relies on the increasing pregnancy rate and decreasing the risk of premature ovulation and ovarian hyperstimulation syndrome. They are also designed to avoid weekend oocyte retrievals. Combined oral contraceptive (OC) pills are among the medicines used to accomplish these objectives. Alternatively, estradiol can be used instead of OC to obtain similar results. The aim of our study was to compare the differences in pregnancy rates (PRs), implantation rates, and miscarriage rates between a short agonist protocol with estradiol priming and a long protocol with combined OC...
2015: BioMed Research International
John J Zhang, Maciej Feret, Lyndon Chang, Mingxue Yang, Zaher Merhi
OBJECTIVE: The objective of this study was to assess the relationship between BMI and oocyte number and maturity in participants who underwent minimal stimulation (mini-) or conventional IVF. METHODS: Participants who underwent their first autologous cycle of either conventional (n = 219) or mini-IVF (n = 220) were divided according to their BMI to analyze IVF outcome parameters. The main outcome measure was the number of oocytes in metaphase II (MII). Secondary outcomes included the number of total oocytes retrieved, fertilized (2PN) oocytes, cleavage and blastocyst stage embryos, clinical pregnancy (CP), and live birth (LB) rates...
May 2015: Gynecological Endocrinology
Karen Peeraer, Sophie Debrock, Peter De Loecker, C Tomassetti, A Laenen, M Welkenhuysen, L Meeuwis, S Pelckmans, B W Mol, C Spiessens, D De Neubourg, T M D'Hooghe
STUDY QUESTION: Can controlled ovarian stimulation with low-dose human menopausal gonadotrophin (hMG) improve the clinical pregnancy rate when compared with ovarian stimulation with clomiphene citrate (CC) in an intrauterine insemination (IUI) programme for subfertile couples? SUMMARY ANSWER: Ovarian stimulation with low-dose hMG is superior to CC in IUI cycles with respect to clinical pregnancy rate. WHAT IS KNOWN ALREADY: IUI after ovarian stimulation is an effective treatment for mild male subfertility, unexplained subfertility and minimal-mild endometriosis, but it is unclear which medication for ovarian stimulation is more effective...
May 2015: Human Reproduction
Francesca Moro, Elisa Scarinci, Carola Palla, Federica Romani, Alessandra Familiari, Anna Tropea, Emanuele Leoncini, Antonio Lanzone, Rosanna Apa
STUDY QUESTION: Is the treatment with recombinant FSH (rFSH) plus recombinant LH (rLH) more effective than highly purified (HP)-hMG in terms of ongoing pregnancy rate (PR) in women ≥35 years of age undergoing intrauterine insemination (IUI) cycles? SUMMARY ANSWER: The ongoing PR was not significantly different in women treated with rFSH plus rLH or with HP-hMG. WHAT IS KNOWN ALREADY: Although previous studies have shown beneficial effects of the addition of LH activity to FSH, in terms of PR in patients aged over 34 years having ovulation induction, no studies have compared two different gonadotrophin preparations containing LH activity in women ≥35 years of age in IUI cycles...
January 2015: Human Reproduction
Angeline N Beltsos, Mark D Sanchez, Kevin J Doody, Mark R Bush, Alice D Domar, Michael G Collins
BACKGROUND: Administration of exogenous progesterone for luteal phase support has become a standard of practice. Intramuscular (IM) injections of progesterone in oil (PIO) and vaginal administration of progesterone are the primary routes of administration. This report describes the administration preferences expressed by women with infertility that were given progesterone vaginal insert (PVI) or progesterone in oil injections (PIO) for luteal phase support during fresh IVF cycles. METHODS: A questionnaire to assess the tolerability, convenience, and ease of administration of PVI and PIO given for luteal phase support was completed by infertile women diagnosed with PCOS and planning to undergo IVF...
2014: Reproductive Health
Alice Halliday, Ana F Guimaraes, Hayley E Tyrer, Haelly Mejane Metuge, Chounna Ndongmo Winston Patrick, Kengne-Ouafo Jonas Arnaud, Tayong Dizzle Bita Kwenti, George Forsbrook, Andrew Steven, Darren Cook, Peter Enyong, Samuel Wanji, Mark J Taylor, Joseph D Turner
BACKGROUND: New drugs effective against adult filariae (macrofilaricides) would accelerate the elimination of lymphatic filariasis and onchocerciasis. Anti-Onchocerca drug development is hampered by the lack of a facile model. We postulated that SCID mice could be developed as a fmacrofilaricide screening model. METHODS: The filaricides: albendazole (ABZ), diethylcarbamazine (DEC), flubendazole (FBZ), ivermectin (IVM) and the anti-Wolbachia macrofilaricide, minocycline (MIN) were tested in Brugia malayi (Bm)-parasitized BALB/c SCID mice vs vehicle control (VC)...
2014: Parasites & Vectors
Nina Rogenhofer, Roman Pavlik, Udo Jeschke, Gabriele Wypior, Robert Ochsenkühn, Christian J Thaler
PROBLEM: We report on a successful ovarian stimulation and pregnancy in a patient with 'resistant ovary syndrome' (ROS) and antigonadotrophin antibodies. ROS is characterized by high endogenous gonadotrophins, low estradiol, normal ovarian antral follicle counts and normal antimuellerian hormone values. METHOD OF STUDY: After cyclical hormone treatment, downregulation with GnRH analogue and ICSI procedure followed. Granulosa cells were treated with LH, FSH or hMG and expression of receptors for FSH, LH, oestrogen receptor beta (ERb) and progesterone receptor A (PR-A) was determined...
February 2015: American Journal of Reproductive Immunology: AJRI
Jianmei Yu, Yanping Ma, Ze Wu, Yonggang Li, Li Tang, Yunxiu Li, Bo Deng
PURPOSE: To assess which is the optimal protocol in terms of endometrial preparation prior to frozen-thawed embryo transfer (FET) in women with polycystic ovarian syndrome (PCOS) and to explore the effect in stimulated cycle with the addition of vaginal 17-β oestradiol. METHODS: Five hundred and seventy-six patients with PCOS were prepared for FET using artificial cycle induced with oestradiol and progesterone supplementation (n = 291) and stimulated cycle induced by human menopausal gonadotrophin (HMG) within or without the addition of vaginal 17-β oestradiol (n = 285)...
January 2015: Archives of Gynecology and Obstetrics
S Sahmay, T A Usta, G Zebitay, L M Senturk, E Oral, P Ocal, M Idil, T Irez
AIM: The aim of this study was to compare human menopausal gonadotropins with recombinant follicle stimulating hormone-follitropin alpha following a long down-regulation protocol in intra cytoplasmic sperm injection cycles in our clinic, and to review the outcomes in the light of preceding studies. METHODS: This was a retrospective study. Among a total number of 2798 patients who had undergone IVF/ICSI applications, 579 eligible patients were included, and their data were evaluated retrospectively...
August 2014: Minerva Ginecologica
José Daniel Machado Rodrigues, Maria Georgina Santos Lapa, Ian Fraser Brockington
OBJECTIVE: To report a case of a substance-induced psychotic disorder secondary to ovulation induction therapy with gonadotrophins. METHOD: Case report. RESULTS: We report a case of a psychotic episode secondary to gonadotrophins therapy. The acute episode was treated with antipsychotic (Aripiprazole). After 2 years the patient remains free of psychotic symptoms. CONCLUSION: There have been several reports correlating low levels of estrogen with psychotic symptoms, leading to studies evaluating the possible effect of this hormone as an antipsychotic...
September 2014: General Hospital Psychiatry
V Leanza, L Coco, F Grasso, G Leanza, G Zarbo, M Palumbo
AIM: Unexplained infertility affects 30% of infertile couples. Management depends on duration of infertility and age of female partner. Ovulation induction, together with intrauterine insemination, is commonly offered to couples with infertility of unknown origin. Intrauterine insemination gained its popularity because it is simple, non-invasive and cost-effective technique. The association with pharmacological stimulation is suitable to induce follicular maturation. The most used drugs to induce ovulation are clomiphene citrate and menopausal or recombinant gonodotropins...
June 2014: Minerva Ginecologica
Tara H Budinetz, Jessica S Mann, Daniel W Griffin, Claudio A Benadiva, John C Nulsen, Lawrence L Engmann
OBJECTIVE: To compare the rate of congenital anomalies, obstetrical complications, and neonatal complications in antagonist cycles where either GnRH agonist (GnRHa) or hCG was used for final oocyte maturation. DESIGN: Retrospective cohort study. SETTING: University-based tertiary fertility center. PATIENT(S): Three hundred ninety-two women under 40 years of age who underwent controlled ovarian stimulation using a GnRH antagonist protocol and who had final oocyte maturation triggered with either a GnRHa or hCG that resulted in pregnancy and delivery after 16 weeks' gestation...
September 2014: Fertility and Sterility
Alvaro Santibáñez Morales, Edgar Omar Colín Licea, Esteban Durán Boullosa, Paola Sánchez Serrano, Olga Pashkova
BACKGROUND: Nowadays various assisted reproduction ovarian stimulation schemes are used for different clinical outcomes is interesting to compare. OBJECTIVE: Compare two ovarian stimulation protocols: recombinant FSH + LH versus recombinant FSH + Menotropins. MATERIAL AND METHODS: Observational, retrospective study, 38 cycles were analyzed, made from 2010 until 2013, assigned to two groups (n = 19 each), group 1 received FSHr + LHr, group 2 received FSHr + menotropins...
May 2014: Ginecología y Obstetricia de México
Tracy Wing Yee Yeung, Joyce Chai, Raymond Hang Wun Li, Vivian Chi Yan Lee, Pak Chung Ho, Ernest Hung Yu Ng
OBJECTIVE: To evaluate whether pretreatment dehydroepiandrosterone (DHEA) supplementation improves ovarian response markers, ovarian response to standard low-dose gonadotropin stimulation, and in vitro fertilization (IVF) outcomes in poor responders. DESIGN: Randomized, double-blind, placebo-controlled pilot study. SETTING: Tertiary reproductive medicine unit. PATIENT(S): Thirty-two women with anticipated poor ovarian response...
July 2014: Fertility and Sterility
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