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James E Frampton
A 1-month formulation of the gonadotrophin-releasing hormone agonist (GnRHa) triptorelin (Decapeptyl® ) has been approved in the EU as an adjuvant treatment in combination with tamoxifen or an aromatase inhibitor (AI), of endocrine-responsive, early-stage breast cancer in women at high risk of recurrence who are confirmed as premenopausal after completion of chemotherapy. This indication reflects the results of the 5-year SOFT and TEXT studies, especially SOFT, in which ovarian function suppression (OFS; mainly achieved with triptorelin) added to tamoxifen provided a significant benefit in the overall study population of premenopausal patients only after adjusting for prognostic factors...
December 2017: Drugs
Sonia Morales Zarcos, Pamela Valdivieso Mejía, Carla Donado Stefani, Pascual Sánchez Martin, Fernando Sánchez Martin
OBJECTIVE: To compare the results obtained with two different GnRH agonist dosages: 0.3mg versus 0.4mg to trigger ovulation in oocyte donor cycles. METHODS: Experimental controlled randomized trial including 40 patients from a private practice center. The patients were randomized into two groups. Group A received a single dose of Triptorelin 0.3mg (Decapeptyl®) 36hours before pick-up. Group B patients received Triptorelin 0.4mg (Decapeptyl®) before pick-up to final oocyte maturation...
September 1, 2017: JBRA Assisted Reproduction
Zhi Jun Zang, Jiancheng Wang, Zhihong Chen, Yan Zhang, Yong Gao, Zhijian Su, Ying Tuo, Yan Liao, Min Zhang, Qunfang Yuan, Chunhua Deng, Mei Hua Jiang, Andy Peng Xiang
Stem Leydig cell (SLC) transplantation could provide a new strategy for treating the testosterone deficiency. Our previous study demonstrated that CD51 (also called integrin αv) might be a putative cell surface marker for SLCs, but the physiological function and efficacy of CD51+ SLCs treatment remain unclear. Here, we explore the potential therapeutic benefits of CD51+ SLCs transplantation and whether these transplanted cells can be regulated by the hypothalamic-pituitary-gonadal (HPG) axis. CD51+ cells were isolated from the testes of 12-weeks-old C57BL/6 mice, and we showed that such cells expressed SLC markers and that they were capable of self-renewal, extensive proliferation, and differentiation into multiple mesenchymal cell lineages and LCs in vitro...
May 2017: Stem Cells
Slawomir Wojniusz, Nina Callens, Stefan Sütterlin, Stein Andersson, Jean De Schepper, Inge Gies, Jesse Vanbesien, Kathleen De Waele, Sara Van Aken, Margarita Craen, Claus Vögele, Martine Cools, Ira R Haraldsen
Central precocious puberty (CPP) develops due to premature activation of the hypothalamic-pituitary-gonadal (HPG) axis, resulting in early pubertal changes and rapid bone maturation. CPP is associated with lower adult height and increased risk for development of psychological problems. Standard treatment of CPP is based on postponement of pubertal development by blockade of the HPG axis with gonadotropin releasing hormone analogs (GnRHa) leading to abolition of gonadal sex hormones synthesis. Whereas the hormonal and auxological effects of GnRHa are well-researched, there is a lack of knowledge whether GnRHa treatment influences psychological functioning of treated children, despite the fact that prevention of psychological problems is used as one of the main reasons for treatment initiation...
2016: Frontiers in Psychology
Rekha Wuntakal, Srividya Seshadri, Ana Montes, Geoff Lane
BACKGROUND: Ovarian cancer is seventh most common cancer in women worldwide. Approximately 1.3% of women will be diagnosed with ovarian cancer at some point during their life time. The majority of tumours arise from surface of the ovary (epithelial). Two thirds of these women will present with advanced disease, requiring aggressive treatment, which includes debulking surgery (removal of as much disease as possible) and chemotherapy. However, most women (75%) with advanced epithelial ovarian cancer (EOC) will relapse following surgery and chemotherapy...
June 29, 2016: Cochrane Database of Systematic Reviews
Ewa Głąb, Beata Wikiera, Jolanta Bieniasz, Ewa Barg
BACKGROUND: Children with central precocious puberty (CPP) present various somatic and psychological abnormalities. OBJECTIVES: The aim of the study was to evaluate growth changes in girls with central precocious puberty treated with GnRH analog therapy and to analyze the factors affecting the auxological response to this treatment. MATERIAL AND METHODS: The study group consisted of 40 girls with puberty onset aged 6.0 ± 1.9 years (mean, ± SD), treated with 3...
January 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
P Cornford, K Jefferson, O Cole, J S Gilbody, V Nayar, G Auddy
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Rita Tomczy, Katarzyna Paluch, Anna Gałuszka-Bednarczyk, Tomasz Milewicz, Jarosław Janeczko, Marek Klocek
UNLABELLED: The aim of the study was to evaluate changes in blood pressure and heart rate in women undergoing controlled ovarian stimulation (COH) in preparation for assisted reproduction techniques. Material and method: The comparison of blood pressure and heart rate measurements obtained from 5 women (age 35.3 +/- 9.4 years) was performed. The data were collected during the 24-hour ambulatory blood pressure monitoring (ABPM) using Holcard sphygmomanometer CR-07 Aspel S.A. at the beginning and in the last day of short protocol of COH with the use of triptorelin (Decapeptyl 0...
2015: Przegla̧d Lekarski
Hsiao-Fan Kung, Ming-Jer Chen, Hwa-Fen Guua, Ya-Fang Chen, Yu-Chiao Yi, Jason Yen-Ping Ho, Min-Min Chou
BACKGROUND: The role of midluteal phase gonadotropin-releasing hormone (GnRH) agonist had been an issue of debate. The aim of this retrospective study was to evaluate the effect of a mid-luteal phase GnRH agonist as an additional luteal phase support (LPS) in patients receiving intracytoplasmic sperm injection (ICSI). Additionally, we elucidate which subgroup would gain the most benefit from GnRH agonist as LPS. METHODS: The medical records were retrieved from January 2009 to January 2012 and a total of 348 patients receiving ICSI were included in this retrospective study...
October 2014: Journal of the Chinese Medical Association: JCMA
Amr M Salaheldin Abdel Hamid, Wael A Ismail Madkour, Ashraf Moawad, Mohamed Abd Elzaher, Mary P Roberts
AIM: The aim of this study was to compare the efficiency of dopamine agonist, Cabergoline, in decreasing the size of endometrioma, with that of luteinizing hormone releasing hormone (LHRH) agonist, triptorelin acetate. STUDY: This was a prospective, randomized study. SETTING: The setting was in two private medical centers in the UAE, from January 2011 to February 2012. PATIENTS AND METHODS: One hundred and forty patients complaining of endometrioma, and fulfilling the eligibility criteria, were chosen and divided into two groups as follows: Group I comprised 71 patients; all of them received Cabergoline tablets, 0...
October 2014: Archives of Gynecology and Obstetrics
Maryam Eftekhar, Elham Rahmani, Farnaz Mohammadian
BACKGROUND: Gonadotrophin-releasing hormone (GnRH) agonist is used for controlling ovarian stimulation in assisted reproductive technology (ART) cycles which has some benefits. OBJECTIVE: To compare the efficacy of two different formulations of GnRH agonist: short-acting and long-acting, for ART protocols. MATERIALS AND METHODS: In a prospective randomized study, one hundred women who underwent ART cycles were randomly divided into two groups...
February 2013: Iranian Journal of Reproductive Medicine
Afsaneh Niakani, Farah Farrokhi, Shapour Hasanzadeh
BACKGROUND: Gonadotropin-releasing hormone (GnRH) is a reproductive key hormone. The GnRH analogues are widely used in in vitro fertilization and treatment of sex hormone-depended cancers induced by the materials used in chemotherapeutic agents. OBJECTIVE: The aim of this study is to evaluate the effects of cyclophosphamide and decapeptyl (analogues of GnRH) on histomorphometry and stereology of testicular tissue as well as gonadotropic and gonadal hormones indices in mice...
October 2013: Iranian Journal of Reproductive Medicine
Fariba Almassinokiani, Abolfazl Mehdizadeh, Elahe Sariri, Mansour Rezaei, Alireza Almasi, Hossein Akbari, Abdolreza Pazooki, Masoud Solaymani-Dodaran, Sara Asadollah, Jila Amirkhani, Shahla Chaichian, Mansoureh Vahdat, Ashrafsadat Moosavi, Monir Ashouri, Zeinab Tamannaei
BACKGROUND: To compare efficacy of simvastatin with GnRHa (Decapeptyl 3.75 mg) on endometriosis-related pains following surgery for endometriosis. MATERIAL/METHODS: Sixty women with pelvic endometriosis, after laparoscopic diagnosis and conservative laparoscopic surgery, were treated with either simvastatin (n=30) for 16 weeks or Decapeptyl (n=30) every 4 weeks for 4 doses. RESULTS: Using VAS, the score of dyspareunia, dysmenorrhea, and pelvic pain 6 months after laparoscopic surgery declined significantly in both groups (p=0...
2013: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Eliezer Witztum, Netzer Daie, Ayala Daie-Gabai, Ariel Rosler
BACKGROUND: Evidence has started to accumulate that relates pedophilia to a history of being a victim of sexual abuse as well as to comorbidity with organic vulnerabilities. During a naturalistic study regarding treatment of pedophilia, the authors had access to clinical and psychodiagnostic evaluations of Israeli Jewish ultraorthodox male pedophiles outside the forensic system. Using psychiatric examination as well as a battery of psychological tests, presence of history of trauma as well as comorbidity with organic vulnerabilities among this unique sub-group was examined...
2012: Israel Journal of Psychiatry and related Sciences
Per Olov Hedlund, Robert Johansson, Jan Erik Damber, Inger Hagerman, Peter Henriksson, Peter Iversen, Peter Klarskov, Peter Mogensen, Finn Rasmussen, Eberhard Varenhorst
OBJECTIVE: This study aimed to evaluate prognostic risk factors for cardiovascular events during treatment of metastatic prostate cancer patients with high-dose parenteral polyoestradiol phosphate (PEP, Estradurin®) or combined androgen deprivation (CAD) with special emphasis on pretreatment cardiovascular disease. MATERIAL AND METHODS: Nine-hundred and fifteen patients with T0-4, Nx, M1, G1-3, hormone- naïve prostate cancer were randomized to treatment with PEP 240 mg i...
November 2011: Scandinavian Journal of Urology and Nephrology
V Rouach, S Katzburg, Y Koch, N Stern, D Somjen
Estrogen deficiency as the sole factor underlying post-menopausal osteoporosis was challenged, in light of reports that both follicular stimulation hormone (FSH) receptor and FSHβ knockout mice were resistant to bone loss, suggesting a detrimental role for FSH. We assessed whether lowering FSH levels by gonadotropin realizing (GnRH) analog decapeptyl in ovariectomized female rats (OVX) affects bone. Wistar-derived 25 days old OVX female rats were injected for 10 weeks with estradiol-17β (E(2)), with GnRH analog (decapeptyl) or with both...
January 2011: Journal of Cellular Biochemistry
A Guivarc'h-Levêque, P Arvis, J-L Bouchet, P-L Broux, L Moy, G Priou, J Vialard, D Colleu
OBJECTIVE: Assess the efficiency of estradiol programming in In Vitro Fertilization (IVF) with antagonists by comparing with classical long luteal agonist protocol. PATIENTS AND METHODS: It is a prospective randomized study, comparing 426 cycles in the arm estradiol antagonist with 412 cycles in the arm long agonist. Estradiol 4 mg/day begins on the 25th day of the previous cycle and continues during the menses until the first day of the stimulation which is from Thursday to Sunday whatever the beginning of the menses...
January 2010: Gynécologie, Obstétrique & Fertilité
Ewa Głab, Ewa Barg, Beata Wikiera, Marcin Grabowski, Anna Noczyńska
THE AIM OF THE STUDY: Was to evaluate the body mass index (BMI) changes in girls with central precocious puberty (CPP) treated with a GnRH analog (GnRHa) and to analyse the factors affecting BMI. MATERIAL AND METHODS: 43 girls with puberty onset aged (mean, +/-SD) 6.1+/-1.9, treated with 3.75 mg Decapeptyl Depot i.m. every 28 days. The treatment was initiated at the age of 7.5+/-2.1 year and continued for 3.3+/-2.2 year until the age of 11.4+/-0.9 year. The height, weight and BMI data were evaluated before, during and after GnRH agonist administration...
2009: Pediatric Endocrinology, Diabetes, and Metabolism
E Kovachev
UNLABELLED: OHSS is a serious complication of COH and PCOS is a major risk factor for its development. OBJECTIVE: The objective of this study is to evaluate the effect of the application of GnRH-agonist in patients with PCOS for triggering the ovulation and prophylactic of OHSS. MATERIALS AND METHODS: In the present study we evaluated 29 patients with PCOS who had been stimulated for the purposes of ART with gonadotrophins and GnRH-antagonist and application of GnRH-agonist (Decapeptyl; Dipherilyn-0...
2008: Akusherstvo i Ginekologii︠a︡
A V Schally
The discovery of hypothalamic hormones was briefly reviewed. The development of new hormonal methods for the therapy of various cancers based on analogues of hypothalmic hormones is then presented. My group isolated luteininzing hormone-releasing hormone (LH-RH), also known as Gn-RH, from pig hypothalmi, elucidated its amino acid sequence, and synthesized it in 1971. The interest in medical applications of LH-RH led to the synthesis of LH-RH analogues by various groups. LH-RH agonists substituted in positions 6 or 10 including Decapeptyl, Leuprolide and Zoladex are much more active than LH-RH and on continuous administration produce inhibition of pituitary and gonads...
May 2008: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
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