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https://www.readbyqxmd.com/read/29754770/skewing-effect-of-sulprostone-on-dendritic-cell-maturation-compared-with-dinoprostone
#1
Jenny Bulgarelli, Laura Fiammenghi, Serena Cassan, Anna Maria Granato, Massimiliano Petrini, Elena Pancisi, Valentina Soldati, Francesco De Rosa, Laura Ridolfi, Angela Riccobon, Massimo Guidoboni
BACKGROUND: Dendritic cells (DCs) are the most efficient antigen-presenting cells and act at the center of the immune system owing to their ability to control both immune tolerance and immunity. In cancer immunotherapy, DCs play a key role in the regulation of the immune response against tumors and can be generated ex vivo with different cytokine cocktails. METHODS: We evaluated the feasibility of dinoprostone (PGE2 ) replacement with the molecular analog sulprostone, in our good manufacturing practice (GMP) protocol for the generation of DC-based cancer vaccine...
May 10, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29747591/misoprostol-vaginal-insert-versus-misoprostol-vaginal-tablets-for-the-induction-of-labour-a-cohort-study
#2
Daniele Bolla, Saskia Vanessa Weissleder, Anda-Petronela Radan, Maria Luisa Gasparri, Luigi Raio, Martin Müller, Daniel Surbek
BACKGROUND: Misoprostol vaginal insert for induction of labor has been recently reported to be superior to dinoprostone vaginal insert in a phase III trial, but has never been compared to vaginal misoprostol in another galenic form. The aim of this study was to compare misoprostol vaginal insert (MVI) with misoprostol vaginal tablets (MVT) for induction of labor in term pregnancies. METHODS: In this retrospective cohort study we compared 200 consecutive women induced with 200-μg misoprostol 24-h vaginal insert (Misodel®) with a historical control of 200 women induced with Misoprostol 25-μg vaginal tablets (Cytotec®) every 4-6 h...
May 10, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29739262/comparison-of-prostaglandin-and-mechanical-cervical-ripening-in-the-setting-of-small-for-gestational-age-neonates
#3
Robert M Rossi, Carri R Warshak, Heather R Masters, Jodi K Regan, Sara A Kritzer, Kristin P Magner
OBJECTIVE: To determine whether cervical ripening with misoprostol (MP) is associated with higher rates of cesarean delivery (CD) (CD) compared to dinoprostone (DP) or Pitocin/Foley balloon (PFB) in infants found to be small for gestational age (SGA). STUDY DESIGN: Single center institution based cohort study of all inductions between 2008-2012 where birth weight was found to be as SGA (< 10th percentile). Maternal demographic, obstetric, and labor characteristics were compared between SGA births where cervical ripening with MP, Mode compares MP to referent group (DP), or PFB was used as the primary agent...
May 8, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29699891/electrohysterographic-characterization-of-the-uterine-myoelectrical-response-to-labor-induction-drugs
#4
Carlos Benalcazar-Parra, Yiyao Ye-Lin, Javier Garcia-Casado, Rogelio Monfort-Orti, Jose Alberola-Rubio, Alfredo Perales, Gema Prats-Boluda
Labor induction is a common practice to promote uterine contractions and labor onset. Uterine electrohysterogram (EHG) has proved its suitability for characterizing the uterus electrophysiological condition in women with spontaneous labor. The aim of this study was to characterize and compare uterine myoelectrical activity during the first 4 h in response to labor induction drugs, Misoprostol (G1) and Dinoprostone (G2), by analyzing the differences between women who achieved active phase of labor and those who did not (successful and failed inductions)...
April 23, 2018: Medical Engineering & Physics
https://www.readbyqxmd.com/read/29545854/application-effect-of-single-balloon-catheters-in-labor-induction-of-pregnant-women-in-late-term-pregnancy-and-their-influences-on-stress-and-inflammatory-responses
#5
Yun Chai, Miaomiao Qu, Meng Jin
This study was designed to evaluate the application effect of single balloon catheters and dinoprostone on promoting cervical ripening of pregnant women in late-term pregnancy and their influences on stress and inflammatory responses. A total of 160 pregnant women with indications of labor induction were included and randomly divided into the control (n=80) and observation (n=80) groups. Patients in the control group received labor induction by administration of dinoprostone at the vaginal vault, while those in the observation group received labor induction by domestic single balloon catheters...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29486612/response-to-letter-to-the-editor-early-amniotomy-after-dinoprostone-insert-used-for-the-induction-of-labor
#6
Evrim Bostanci, Ahmet Eser, Cigdem Yayla Abide, Cetin Kılıccı, Mehmet Kucukbas
No abstract text is available yet for this article.
February 27, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29473764/effects-of-gestational-diabetes-mellitus-on-time-to-delivery-and-pregnancy-outcomes-in-full-term-pregnancies-with-dinoprostone-labor-induction
#7
Ting-Ting Jiang, Lei Zhao, Ying Lin, Dong Zhou, Ling Wang, Guo-Qiang Sun, Mei Xiao
OBJECTIVE: To investigate the effects of gestational diabetes mellitus (GDM) on time to delivery and perinatal outcomes in full-term pregnancies underwent dinoprostone-induced labor. METHODS: GDM patients that underwent labor induction with dinoprostone vaginal inserts were retrospectively recruited. Full-term pregnancies with normal glucose tolerance (NGT) that underwent labor induction at the same period were recruited as control. Time to delivery and perinatal outcomes were compared between the two groups...
February 23, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29376620/oral-misoprostol-versus-intravaginal-dinoprostone-for-labor-induction-a-comparison-study
#8
Caterina Neri, Alessandra Familiari, Francesco Preziosi, Chiara Vassallo, Angela Botta, Antonio Lanzone, Brigida Carducci, Alessandro Caruso
BACKGROUND: Labor induction (IOL) is one of the most common procedures performed in obstetrics, accounting for about the 20% of deliveries in the developed countries and it still represents a challenge to obstetricians. PURPOSE: The aim of this study is the comparison between two techniques for induction of Labor (IOL): oral Misoprostol and Propess. MATERIALS AND METHODS: Restrospective study in a single tertiary referral center. Clinical maternal, fetal and neonatal informations were recorded...
January 26, 2018: Minerva Ginecologica
https://www.readbyqxmd.com/read/29334294/comments-on-manuscript-early-amniotomy-after-dinoprostone-insert-used-for-the-induction-of-labor
#9
Ahmed M Abbas
No abstract text is available yet for this article.
January 23, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29291357/associations-of-hypertensive-disorders-of-pregnancy-and-outcomes-of-labor-induction-with-prostaglandin-vaginal-inserts
#10
Lili Sheibani, Kyle Raymond, Olof Rugarn, Deborah A Wing
OBJECTIVE: To evaluate the association between hypertensive (HTNsive) disorders of pregnancy and outcomes of labor induction, in two cohorts of women induced with either misoprostol vaginal insert (MVI) or dinoprostone vaginal insert (DVI). STUDY DESIGN: This investigation was a post-hoc analysis of data from three Phase II and III, multi-center, double blind, randomized controlled trials of women induced with identical efficacy endpoints. A competing risk framework investigated the association between HTNsive disorders of pregnancy and the time-to-event endpoints of onset of active labor and vaginal delivery...
February 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29251182/comparison-of-labour-induction-with-misoprostol-and-dinoprostone-and-characterization-of-uterine-response-based-on-electrohysterogram
#11
Carlos Benalcazar-Parra, Rogelio Monfort-Orti, Yiyao Ye-Lin, Gema Prats-Boluda, Jose Alberola-Rubio, Alfredo Perales, Javier Garcia-Casado
OBJECTIVE: The objective of this study is to compare the uterine activity response between women administered dinoprostone (prostaglandin E2) and misoprostol (prostaglandin E1) for induction of labour (IOL) by analysing not only the traditional obstetric data but also the parameters extracted from uterine electrohysterogram (EHG). METHODS: Two cohorts were defined: misoprostol (25-µg vaginal tablets; 251 women) and dinoprostone cohort (10 mg vaginal inserts; 249 women)...
December 17, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29196154/labour-induction-practices-in-france-a-population-based-declarative-survey-in-94-maternity-units
#12
P Blanc-Petitjean, M Salomé, C Dupont, C Crenn-Hebert, A Gaudineau, F Perrotte, P Raynal, E Clouqueur, G Beucher, B Carbonne, F Goffinet, C Le Ray
INTRODUCTION: In 2016, 22.0% of deliveries in France were induced. The current lack of high level of evidence data about the methods and indications for induction of labour has promoted heterogeneous and non-recommended practices. The extent of these different practices is not adequately known in France today, although they may influence perinatal outcomes. The objective of this study was to report current practices of induction of labour in France. MATERIAL AND METHODS: This study surveyed 94 maternity units in seven perinatal networks...
February 2018: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29162633/use-of-prostaglandins-in-duct-dependent-congenital-heart-conditions
#13
Yogen Singh, Paraskevi Mikrou
Congenital heart disease (CHD) remains a leading cause of infant mortality, which is even higher in infants with undiagnosed duct-dependent CHDs. Up to 39%-50% of infants with critical CHD are being discharged undiagnosed from the hospital. Infants with duct-dependent critical CHD remain well during the fetal period and may deteriorate when the ductus arteriosus (commonly called 'duct') closes after birth. It is critical to open or maintain ductus arteriosus patent in infants with duct-dependent CHDs. Prostaglandin E1 (alprostadil marketed as 'Prostin VR ') and prostaglandin E2 (dinoprostone) are used to maintain a patent ductus arteriosus and the dose of medication depends on the clinical presentation...
November 21, 2017: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/29138519/time-to-delivery-and-delivery-outcomes-comparing-three-methods-of-labor-induction-in-7551-nulliparous-women-a-population-based-cohort-study
#14
C Lindblad Wollmann, M Ahlberg, G Petersson, S Saltvedt, O Stephansson
OBJECTIVE: Determine time-to-delivery and mode-of-delivery in labor induction among women with unripe cervix. STUDY DESIGN: 7551 nulliparous women with singleton deliveries, ⩾37 weeks, Bishop Score ⩽6, induced with dinoprostone, misoprostol or transcervical single balloon catheter. Linear regression analysis was used to estimate mean time-to-delivery with β-estimates and 95% confidence intervals with adjustments. Multivariable logistic regression analysis was used to calculate odds of cesarean delivery, instrumental vaginal delivery, maternal and neonatal outcomes...
November 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29124067/labor-induction-with-orally-administrated-misoprostol-a-retrospective-cohort-study
#15
Tove Wallstrom, Hans Jarnbert-Pettersson, David Stenson, Helena Akerud, Elisabeth Darj, Kristina Gemzell-Danielsson, Eva Wiberg-Itzel
Introduction: One great challenge in obstetric care is labor inductions. Misoprostol has advantages in being cheap and stable at room temperature and available in resource-poor settings. Material and Methods: Retrospective cohort study of 4002 singleton pregnancies with a gestational age ≥34 w at Sodersjukhuset, Stockholm, during 2009-2010 and 2012-2013. Previously used methods of labor induction were compared with misoprostol given as a solution to drink, every second hour...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28969216/decreased-foetal-movements-secondary-to-uterine-septum-a-case-report-and-proposed-algorithm-of-management
#16
Eram Ali, Tamkin Khan, Deeba Khanam
Congenital uterine anomaly has been well established as cause of infertility and recurrent pregnancy loss. However, only few studies have reported the association of mullerian anomalies and adverse pregnancy outcome in third trimester. We are hereby reporting a case of 25-year- old female second gravida who presented at 36 weeks six days pregnancy with complaint of decreased foetal movements for the past two weeks. The female had previous history of multiple admissions on account of decreased foetal movements in the third trimester...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28963922/risk-of-maternal-fetal-and-neonatal-complications-associated-with-the-use-of-the-transcervical-balloon-catheter-in-induction-of-labour-a-systematic-review
#17
REVIEW
Jip S M Gommers, Milou Diederen, Chris Wilkinson, Deborah Turnbull, Ben W J Mol
Induction of labour is one of the most frequently applied obstetrical interventions globally. Many studies have compared the use of balloon catheters with pharmacological agents. Although the safety of the balloon catheter is often mentioned, little has been written about the total spectrum of maternal and fetal morbidity associated with induction of labour using a balloon catheter. We evaluated the safety of labour induction with a transcervical balloon catheter by conducting a literature review with pooled risk assessments of the maternal, fetal and neonatal morbidity...
November 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28912192/mechanical-cervical-ripening-for-women-with-prolongedpregnancies-magpop-protocol-for-a-randomised-controlled-trial-of-a-silicone-double-balloon-catheter-versus-the-propess-system-for-the-slow-release-of-dinoprostone-for-cervical-ripening-of-prolonged-pregnancies
#18
Caroline Diguisto, Amélie Le Gouge, Bruno Giraudeau, Franck Perrotin
INTRODUCTION: Induction of labour for prolonged pregnancies (PP) when the cervix is unfavourable is a challenging situation. Cervical ripening by pharmacological or mechanical techniques before oxytocin administration is used to increase the likelihood of vaginal delivery. Both techniques are equally effective in achieving vaginal delivery but excessive uterine activity, which induces fetal heart rate (FHR) anomalies, is more frequent after the pharmacological intervention. We hypothesised that mechanical cervical ripening could reduce the caesarean rate for non-reassuring FHR especially in PP where fetuses are already susceptible to this...
September 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/28886702/safety-and-effectiveness-of-oral-misoprostol-for-induction-of-labour-in-a-resource-limited-setting-a-dose-escalation-study
#19
Marilyn Morris, John W Bolnga, Ovoi Verave, Jimmy Aipit, Allanie Rero, Moses Laman
BACKGROUND: Oral misoprostol as an induction of labour (IOL) agent is rapidly gaining popularity in resource-limited settings because it is cheap, stable at ambient temperatures, and logistically easier to administer compared to dinoprostone and oxytocin. We aim to investigate the safety and effectiveness of a regimen of oral misoprostol in Papua New Guinean women undergoing IOL. METHODS: As part of a prospective dose escalation study conducted at Modilon Hospital in Papua New Guinea, women with a singleton pregnancy in cephalic presentation and an unfavourable cervix who gave written informed consent were administered oral misoprostol, commencing at 25mcg once every 2 h for 4 doses and increased to 50mcg once every 2 h for 8 doses within 24 h...
September 8, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28831553/efficacy-and-safety-of-misoprostol-dinoprostone-and-cook-s-balloon-for-labour-induction-in-women-with-foetal-growth-restriction-at-term
#20
COMPARATIVE STUDY
Jorge Duro-Gómez, María Fernanda Garrido-Oyarzún, Ana Belén Rodríguez-Marín, Antonio Jesús de la Torre González, José Eduardo Arjona-Berral, Camil Castelo-Branco
BACKGROUND AND OBJECTIVES: To compare effectiveness and safety of dinoprostone, misoprostol and Cook's balloon as labour-inducing agents in women with intrauterine growth restriction (IUGR) at term. METHODS: Retrospective cohort chart review of women diagnosed with foetal growth restriction at term in Reina Sofia Hospital, Cordoba, Spain from January 2014 to December 2015. Registration of baseline characteristics and method of induction was made. The main outcome was time from induction to delivery...
October 2017: Archives of Gynecology and Obstetrics
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