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Hatice Kansu-Celik, Ozlem Gun-Eryılmaz, Nasuh Utku Dogan, Seval Haktankaçmaz, Mehmet Cinar, Saynur Sarici Yilmaz, Cavidan Gülerman
BACKGROUND: We aimed to evaluate the efficacy and safety of dinoprostone for cervical ripening and labor induction in patients with term oligohydramnios and Bishop score ≤ 5. METHODS: This was a prospective case-control study, which included 104 consecutive women with a Bishop score≤5. Participants were divided into two groups. Women with term isolated oligohydramnios and Bishop score≤5 underwent induction of labor with a vaginal insert containing 10-mg timed-release dinoprostone (prostaglandin E2; Group A, n=40)...
October 10, 2016: Journal of the Chinese Medical Association: JCMA
Nada Aracic, Ivica Stipic, Ivana Jakus Alujevic, Petar Poljak, Mario Stipic
AIM: To evaluate the influence of cervical length (CL) and parity as prediction factors for assessment of cesarean section (CS) risk in women with premature rupture of membranes (PROM) at term and unfavorable cervix, undergoing induction of labor (IOL) with dinoprostone intracervical gel. METHODS: A prospective study involved 50 nulliparous and 51 multiparous women admitted for IOL. Pre-induction CL was measured and delivery outcomes were recorded. RESULTS: Nulliparous women were younger than the multiparous (26...
October 8, 2016: Journal of Perinatal Medicine
Braganza Veena, Rajinish Samal, Leeberk R Inbaraj, Carolin Elizabeth George
BACKGROUND: Prostaglandins are popular agents for induction of labour, owing to their dual action of cervical ripening and inducing uterine contractions. Sublingual misoprostol offers high efficacy as it bypasses first-pass metabolism. Researchers have proved that intracervical PGE1 is as effective as PGE2 except for increased caesarean rate and hyperstimulation. Limited knowledge is available on the efficacy of sublingual PGE1 and intracervical PGE2. This study was designed to compare the effectiveness of sublingual PGE1 with intracervical PGE2...
October 2016: Journal of Obstetrics and Gynaecology of India
P Tsikouras, Z Koukouli, B Manav, M Soilemetzidis, A Liberis, R Csorba, G Trypsianis, G Galazios
INTRODUCTION: We undertook a prospective cohort study to compare the effectiveness and safety of 50 µg misoprostol versus 3 mg dinoprostone in two vaginal doses 6 hours apart, followed if necessary by oxytocin for labor induction in low-risk post-term (> 40 weeks) pregnancies with unfavorable cervix (Bishop score ≤ 6). METHODS: Labor induction and subsequent management were conducted using a standardized protocol. The primary outcome of the study was labor induction rate...
July 2016: Geburtshilfe und Frauenheilkunde
Silvia Poma, Luigia Scudeller, Barbara Gardella, Federica Broglia, Maria Ciceri, Marinella Fuardo, Simona Pellicori, Filippo Repossi, Silvia Zizzi, Silvano Noli, Maria Paola Delmonte, Giorgio Antonio Iotti
PURPOSE: Induced labor is associated with a higher request for analgesia than spontaneous labor. This study compared duration of labor, mode of delivery, quantity of blood loss, type of perineal outcome and neonatal outcomes between women in induced labor and women in spontaneous labor, both on epidural analgesia (administered at cervical dilation  ≤ 4 cm). METHODS: In a two-year longitudinal cohort study, data were gathered from nulliparous women with a single cephalic pregnancy of at least 37 weeks attending the labor and delivery ward in Policlinico San Matteo Fundation-Pavia...
July 13, 2016: Journal of Maternal-fetal & Neonatal Medicine
O Rugarn, D Tipping, B Powers, D A Wing
OBJECTIVE: To assess adverse event (AE) resolution, delivery mode and neonatal outcomes after misoprostol or dinoprostone vaginal insert (MVI or DVI) retrieval due to AE during induction of labour (IOL). DESIGN: Randomised, double-blind trial, EXPEDITE. SETTING: Thirty five obstetric departments, USA. POPULATION: Consisted of 1358 pregnant women with modified Bishop score ≤4 eligible for pharmacological IOL. METHODS: Post hoc analysis...
June 16, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
Bo Ryoung Han, Kyo Hoon Park, Sung Youn Lee, Eun Young Jung, Jeong Woo Park
AIMS: To develop a model based on clinical and ultrasound parameters to predict the risk of cesarean delivery after labor induction in near-term twin gestations. METHODS: This retrospective cohort study included 189 consecutive women with twin gestations at ≥ 36.0 weeks scheduled for labor induction. The Bishop score and transvaginal ultrasonographic measurements of cervical length were obtained immediately before labor induction. Parameters studied included maternal age, height, weight, parity, gestational age, Bishop score, cervical length, epidural analgesia, method of conception, chorionicity and birth weight...
September 2016: Journal of Obstetrics and Gynaecology Research
Christiane Schwarz, Mechthild M Gross, Peter Heusser, Bettina Berger
OBJECTIVE: induction of labour (IOL) is a common procedure in high income countries. It may be conducted for medical as well as non-medical reasons. Women's views on induction of labour have not extensively been evaluated as yet. Also, women's preferences for certain methods of induction including alternative and complementary methods need further exploration in order to meet their expectations and needs. DESIGN AND SETTING: we published a short online questionnaire on women'views and experiences with IOL...
April 2016: Midwifery
Richard Bernhard Mayer, Peter Oppelt, Omar Shebl, Joachim Pömer, Christina Allerstorfer, Christoph Weiss
OBJECTIVE: Only one phase III trial has been published to date on the efficacy and safety of misoprostol vaginal inserts for inducing labor. The aim of this study was to compare misoprostol inserts with dinoprostone inserts. STUDY DESIGN: This retrospective cohort study evaluated the reduction in time to vaginal delivery and delivery within 24h, in routine clinical work, in 119 labor inductions using a 200-μg misoprostol vaginal insert (Misodel(®); June-October 2014) in comparison with 124 inductions using a 10-mg dinoprostone insert (Propess(®); December 2013-April 2014)...
May 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Rodger Duffin, Richard A O'Connor, Siobhan Crittenden, Thorsten Forster, Cunjing Yu, Xiaozhong Zheng, Danielle Smyth, Calum T Robb, Fiona Rossi, Christos Skouras, Shaohui Tang, James Richards, Antonella Pellicoro, Richard B Weller, Richard M Breyer, Damian J Mole, John P Iredale, Stephen M Anderton, Shuh Narumiya, Rick M Maizels, Peter Ghazal, Sarah E Howie, Adriano G Rossi, Chengcan Yao
Systemic inflammation, which results from the massive release of proinflammatory molecules into the circulatory system, is a major risk factor for severe illness, but the precise mechanisms underlying its control are not fully understood. We observed that prostaglandin E2 (PGE2), through its receptor EP4, is down-regulated in human systemic inflammatory disease. Mice with reduced PGE2 synthesis develop systemic inflammation, associated with translocation of gut bacteria, which can be prevented by treatment with EP4 agonists...
March 18, 2016: Science
Huili Jiang, Xue Yu, Xiujun Ren, Ya Tu
OBJECTIVE: To investigate the role of spinal prostaglandin E2 (PGE2) in electroacupuncture (EA) analgesia and assess the theoretical basis for selection of acupoints in the treatment of neuropathic pain. METHODS: A rat model of neuropathic pain was established. Rats were randomly divided into normal, model, sham, EA 1, EA 2, and EA 3 groups. In EA 1 group, the rats were needled at bilateral L5 Jiaji (EX-B2), Dachangshu (BL 25), Weizhong (BL 40) and Kunlun (BL 60)...
February 2016: Journal of Traditional Chinese Medicine, Chung i Tsa Chih Ying Wen Pan
T Draycott, H van der Nelson, C Montouchet, L Ruff, F Andersson
BACKGROUND: In view of the increasing pressure on the UK's maternity units, new methods of labour induction are required to alleviate the burden on the National Health Service, while maintaining the quality of care for women during delivery. A model was developed to evaluate the resource use associated with misoprostol vaginal inserts (MVIs) and dinoprostone vaginal inserts (DVIs) for the induction of labour at term. METHODS: The one-year Markov model estimated clinical outcomes in a hypothetical cohort of 1397 pregnant women (parous and nulliparous) induced with either MVI or DVI at Southmead Hospital, Bristol, UK...
February 10, 2016: BMC Health Services Research
Megan L Stephenson, J Seth Hawkins, Leo Pevzner, Barbara L Powers, Deborah A Wing
OBJECTIVE: The aim of this study is to compare labor outcomes across race/ethnicity in women undergoing prostaglandin labor induction. METHODS: Secondary analysis of misoprostol vaginal insert (MVI) trial, a double-blind, randomized, control trial of 1,308 patients comparing sustained release vaginal inserts containing dinoprostone 10 mg and misoprostol 50 mcg (MVI 50) or 100 mcg (MVI 100). RESULTS: Achievement of active labor and induction failures were similar across race/ethnicity...
June 2015: Journal of Racial and Ethnic Health Disparities
Mieke L G Ten Eikelder, Katrien Oude Rengerink, Marta Jozwiak, Jan W de Leeuw, Irene M de Graaf, Mariëlle G van Pampus, Marloes Holswilder, Martijn A Oudijk, Gert-Jan van Baaren, Paula J M Pernet, Caroline Bax, Gijs A van Unnik, Gratia Martens, Martina Porath, Huib van Vliet, Robbert J P Rijnders, A Hanneke Feitsma, Frans J M E Roumen, Aren J van Loon, Hans Versendaal, Martin J N Weinans, Mallory Woiski, Erik van Beek, Brenda Hermsen, Ben Willem Mol, Kitty W M Bloemenkamp
BACKGROUND: Labour is induced in 20-30% of all pregnancies. In women with an unfavourable cervix, both oral misoprostol and Foley catheter are equally effective compared with dinoprostone in establishing vaginal birth, but each has a better safety profile. We did a trial to directly compare oral misoprostol with Foley catheter alone. METHODS: We did an open-label randomised non-inferiority trial in 29 hospitals in the Netherlands. Women with a term singleton pregnancy in cephalic presentation, an unfavourable cervix, intact membranes, and without a previous caesarean section who were scheduled for induction of labour were randomly allocated to cervical ripening with 50 μg oral misoprostol once every 4 h or to a 30 mL transcervical Foley catheter...
April 16, 2016: Lancet
Tanya M Laidlaw, Joshua A Boyce
No abstract text is available yet for this article.
February 4, 2016: New England Journal of Medicine
(no author information available yet)
The vaginal insert containing misoprostol has more adverse effects related to uterine hyperactivity than the dinoprostone vaginal insert.
December 2015: Prescrire International
Kunzier Nadia Bennett, Hyein Park, Joseph Cioffi, Rose Calixte, Anthony Vintzileos
OBJECTIVE: The objective of this study is to compare resource utilization (efficiency) and obstetrical/cost outcomes of single dose misoprostol versus dinoprostone for induction of labor (IOL) at term. METHODS: Retrospective cohort of induced deliveries 37-41 weeks gestation presenting with a Bishop score ≤4 using single-dose-50 mcg vaginal misoprostol or 10 mg-dinoprostone vaginal-inserts. Dinoprostone patients were compared (5:1) with misoprostol patients...
November 2016: Journal of Maternal-fetal & Neonatal Medicine
Xiu Wang, Aijun Yang, Qingyong Ma, Xuelan Li, Li Qin, Tongqiang He
OBJECTIVE: To evaluate effectiveness and safety of titrated oral misoprostol solution (OMS) in comparison with vaginal dinoprostone for cervix ripening and labor induction in term pregnant women. METHODS: A multicenter randomized controlled trial of women with term singleton pregnancy with indications for labor induction; 481 participants were allocated to receive titrated OMS with different doses by hourly administration according to the procedure or insert vaginal dinoprostone for cervix ripening and labor induction to compare maternal outcomes including indication of labor induction, mode of outcome of delivery, maternal morbidity, and neonatal outcomes between two groups for evaluating the efficacy and safety of titrated oral misoprostol induction...
September 2016: Archives of Gynecology and Obstetrics
Iwona Jagielska, Anita Kazdepka-Ziemińska, Anita Kaczorowska, Anna Madej, Tomasz Kolossa, Marek Grabiec
INTRODUCTION: Postpartum hemorrhage (PPH) constitutes the main cause of delivery-related maternal mortality worldwide. Identification of the risk factors, as well as knowledge about preventive measures and adequate management, allow to limit blood loss. Oxytocin, carbetocin, methylergometrine, dinoprostone, suiprostone, and misoprostol are commonly used drugs in prevention of PPH. OBJECTIVES: The aim of the study was to evaluate the efficacy of carbetocin and oxytocin in prevention of PPH after cesarean section...
September 2015: Ginekologia Polska
Charlotte Patte, Philippe Deruelle
BACKGROUND: Induction of labor is a major issue in pregnancy management. Finding strategies to increase rate and decrease time to vaginal delivery is an important goal, but maternal or neonatal safety must remain the primary objective. Misoprostol is a synthetic analogue of prostaglandin used off label to ripen the cervix and induce labor. The misoprostol vaginal insert (MVI) was designed to allow a controlled-release delivery of misoprostol (from 50 to 200 μg) with a removal tape. The objective of this review was to make a critical appraisal of this device referring to the literature...
2015: International Journal of Women's Health
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