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https://www.readbyqxmd.com/read/29763356/chairside-cad-cam-composite-onlays-for-the-restoration-of-primary-molars
#1
Elisabeth Dursun, Aude Monnier-Da Costa, Christian Moussally
After pulp therapy or with multi-surface caries in primary molars, pre-formed stainless steel crowns are usually placed to ensure tooth longevity. Esthetic alternatives, such as zirconia crowns, have been proposed, but they are invasive. Here we describe two cases of chairside computer-aided design and computer-aided manufacturing (CAD/CAM) technology used to treat extended and/or deep caries on primary molars. A powder-free chairside CAD/CAM system, a milling unit and machinable high-performance composite blocks were used...
May 15, 2018: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29746095/uv-vis-imaging-of-piroxicam-supersaturation-precipitation-and-dissolution-in-a-flow-through-setup
#2
Yu Sun, Alex Chapman, Susan Weng Larsen, Henrik Jensen, Nickolaj Jacob Petersen, David M Goodall, Jesper Ostergaard
Evaluation of drug precipitation is important in order to address challenges regarding low and variable bioavail-ability of poorly water-soluble drugs, to assess potential risk of patient safety with infusion therapy and to explore injectable in situ suspension-forming drug delivery systems. Generally, drug precipitation is assessed in vitro through solution concentra-tion analysis methods. Dual-wavelength UV-Vis imaging is a novel imaging technique which may provide an opportunity for simultaneously monitoring changes in both solution and solid phases during precipitation...
May 10, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29717773/cucurbitacin-b-inhibits-tumor-angiogenesis-by-triggering-the-mitochondrial-signaling-pathway-in-endothelial-cells
#3
Xian-Mei Piao, Feng Gao, Jiu-Xin Zhu, Li-Juan Wang, Xin Zhao, Xin Li, Miao-Miao Sheng, Yan Zhang
Cucurbitacin B (CuB), the active component of a traditional Chinese herbal medicine, Pedicellus Melo, has been shown to exhibit antitumor and anti-inflammation effects, but its role in tumor angiogenesis, the key step involved in tumor growth and metastasis, and the involved molecular mechanism are unknown. Tumor angiogenesis is one of the hallmarks of the development in malignant neoplasias and metastasis. Effective targeting of tumor angiogenesis is a key area of interest for cancer therapy. Here, we demonstrated that CuB significantly inhibited human umbilical vascular endothelial cell (HUVEC) proliferation, migration, tubulogenesis in vitro, and blocked angiogenesis in chick embryo chorioallantoic membrane (CAM) assay in vivo...
April 30, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29710662/antinociceptive-effectiveness-of-tithonia-tubaeformis-in-a-vincristine-model-of-chemotherapy-induced-painful-neuropathy-in-mice
#4
Noor Ul Ain Nawaz, Muhammad Saeed, Khalid Rauf, Muhammad Usman, Mehreen Arif, Zaki Ullah, Naila Raziq
BACKGROUND: Chemotherapy induced peripheral neuropathy (CIPN) is a painful side-effect of commonly used chemotherapeutic agents that profoundly impair the quality of life of patients as the current pharmacotherapeutic strategies are inefficient in providing adequate pain relief. Complementary and alternative medicine (CAM) therapies are preferred by patients with neuropathic pain as they experience insufficient control of pain with conventional medications. This study describes the antinociceptive effect of Tithonia tubaeformis (Jacq...
April 25, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29705447/knowledge-attitude-and-use-of-complementary-and-alternative-medicine-among-nurses-a-systematic-review
#5
REVIEW
Abbas Balouchi, Gholamhossein Mahmoudirad, Marie Hastings-Tolsma, Seyed Afshin Shorofi, Hosien Shahdadi, Abdolghani Abdollahimohammad
OBJECTIVES: The purpose of this study was to systematically review the literature to describe the knowledge, attitude and practice of CAM by nurses. METHODS: Three databases were searched for relevant studies from launch through September of 2017 and included MEDLINE, Scopus and Web of science. RESULTS: The average knowledge of CAM therapies by nurses was 62.2% with attitude about use averaging 65.7%. Close to two-thirds (65.9%) reported use of CAM therapies with patients...
May 2018: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/29704252/baseline-intrahepatic-and-peripheral-innate-immunity-are-associated-with-hepatitis-c-virus-clearance-during-daa-therapy
#6
Hawwa Alao, Maggie Cam, Chithra Keembiyehetty, Fang Zhang, Elisavet Serti, Daniel Suarez, Heiyoung Park, Nicolaas H Fourie, Elizabeth C Wright, Wendy A Henderson, Qisheng Li, T Jake Liang, Barbara Rehermann, Marc G Ghany
OBJECTIVE: Hepatitis C virus (HCV) infection induces interferon-stimulated genes (ISGs) and downstream innate immune responses. This study investigated whether baseline and on-treatment differences in these responses predict response versus virological breakthrough during therapy with direct-acting antivirals (DAA). METHODS: Thirteen HCV genotype 1b-infected patients who had previously failed a course of peginterferon/ribavirin were re-treated with asunaprevir/daclatasvir for 24 weeks...
April 27, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29702268/vascular-entrapment-of-both-the-sciatic-and-pudendal-nerve-causing-persistent-sciatica-and-pudendal-neuralgia
#7
Ahmet Kale, Gulfem Basol, Taner Usta, Isa Cam
STUDY OBJECTIVE: To demonstrate the laparoscopic approach to malformed branches of the vessels entrapping the nerves of the sacral plexus. DESIGN: A step-by-step explanation of the surgery using video (instructive video). The Ethics Committee ruled that approval was not required for this video. SETTING: Derince Education and Research Hospital, Turkey PATIENT: : The 26-year-old patient who had failed the medical therapy, complained about numbness and burning pain on the right side of the vagina and pain radiating to the lower limb for approximately 36 months period...
April 24, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29700410/internalization-of-cd239-highly-expressed-in-breast-cancer-cells-a-potential-antigen-for-antibody-drug-conjugates
#8
Yamato Kikkawa, Yurie Enomoto-Okawa, Aiko Fujiyama, Takeshi Fukuhara, Nozomi Harashima, Yumika Sugawara, Yoichi Negishi, Fumihiko Katagiri, Kentaro Hozumi, Motoyoshi Nomizu, Yuji Ito
Antibody-drug conjugates (ADCs) are attractive in cancer therapy because they can directly bind to cancer cells and provide anticancer activity. To kill cancer cells with ADCs, the target antigens are required not only to be highly and/or selectively expressed on cancer cells but also internalized by the cells. CD239, also known as the Lutheran blood group glycoprotein (Lu) or basal cell adhesion molecule (B-CAM), is a specific receptor for laminin α5, a major component of basement membranes. Here, we show that CD239 is strongly expressed in a subset of breast cancer cells and internalized into the cells...
April 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29695547/an-improved-in-vivo-methodology-to-visualise-tumour-induced-changes-in-vasculature-using-the-chick-chorionic-allantoic-membrane-assay
#9
Naside Mangir, Ahtasham Raza, John W Haycock, Christopher Chapple, Sheila Macneil
BACKGROUND/AIM: Decreasing the vascularity of a tumour has proven to be an effective strategy to suppress tumour growth and metastasis. Anti-angiogenic therapies have revolutionized the treatment of advanced-stage cancers, however there is still demand for further improvement. This necessitates new experimental models that will allow researchers to reliably study aspects of angiogenesis. The aim of this study was to demonstrate an in vivo technique in which the highly vascular and accessible chorioallantoic membrane (CAM) of the chick embryo is used to study tumour-induced changes in the macro and microvessels...
May 2018: In Vivo
https://www.readbyqxmd.com/read/29694466/computer-aided-design-computer-assisted-manufacture-derived-needle-guide-for-injection-of-botulinum-toxin-into-the-lateral-pterygoid-muscle-in-patients-with-oromandibular-dystonia
#10
Kazuya Yoshida
AIMS: To evaluate the effectiveness and safety of botulinum toxin administration into the inferior head of the lateral pterygoid muscle of patients with jaw opening dystonia by using a computer-aided design/computer-assisted manufacture (CAD/CAM)-derived needle guide. METHODS: A total of 17 patients with jaw opening dystonia were enrolled. After the patient's computed tomography (CT) scan was imported and fused with a scan of a plaster cast model of the maxilla, the optimal needle insertion site over the lateral pterygoid muscle was determined using the NobelClinician software...
April 2018: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29693115/novel-zinc%C3%A2-and-silicon%C3%A2-phthalocyanines-as-photosensitizers-for-photodynamic-therapy-of-cholangiocarcinoma
#11
Jacob Schmidt, Weronika Kuzyniak, Janine Berkholz, Gustav Steinemann, Racheal Ogbodu, Björn Hoffmann, Geraldine Nouailles, Ayşe Gül Gürek, Bianca Nitzsche, Michael Höpfner
Photodynamic therapy (PDT) has emerged as an effective and minimally invasive cancer treatment modality. In the present study, two novel phthalocyanines, tetra‑triethyleneoxysulfonyl substituted zinc phthalocyanine (ZnPc) and dihydroxy‑2,9(10),16(17),23(24)‑tetrakis(4,7,10‑trioxaundecan‑1‑sulfonyl) silicon phthalocyanine (Pc32), were investigated as photosensitizers (PS) for PDT of cholangiocarcinoma (CC). ZnPc showed a pronounced dose‑dependent and predominantly cytoplasmic accumulation in EGI‑1 and TFK‑1 CC cell lines...
April 16, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29675931/efficacy-studies-of-sclerotium-rolfsii-lectin-on-breast-cancer-using-nod-scid-mouse-model
#12
Prajna Hegde, Jagadeesh Narasimhappagari, Bale M Swamy, Shashikala R Inamdar
Expression of altered glycans like TF, Tn and sTn antigens has been observed in a number of carcinomas which are targeted in cancer therapy. Sclerotium rolfsii lectin (SRL) is known to recognize TF and its substituted forms. Clinical potential of SRL has been demonstrated by studying its interaction with different types of cancer cells. Here we report, in vitro studies of SRL on breast cancer MDA-MB-468 cells and in vivo studies with MCF-7 xenografts. In vitro growth inhibitory studies of SRL on metastatic triple negative breast cancer MDA-MB-468 cells was performed by MTT assay, flow cytometry, adhesion and CAM assay...
April 20, 2018: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29668401/phase-ii-randomized-controlled-trial-of-constraint-induced-movement-therapy-in-multiple-sclerosis-part-2-effect-on-white-matter-integrity
#13
Ameen Barghi, Jane B Allendorfer, Edward Taub, Brent Womble, Jarrod M Hicks, Gitendra Uswatte, Jerzy P Szaflarski, Victor W Mark
BACKGROUND: Constraint-induced movement therapy (CIMT) is a method of physical rehabilitation that has demonstrated clinical efficacy in patients with chronic stroke, cerebral palsy, and multiple sclerosis (MS). OBJECTIVE: This pilot randomized controlled trial tested whether CIMT can also induce increases in white matter integrity in patients with MS. METHODS: Twenty adults with chronic hemiparetic MS were randomized to receive either CIMT or complementary and alternative medicine (CAM) treatment (reported in the first article of this pair)...
March 2018: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29668399/phase-ii-randomized-controlled-trial-of-constraint-induced-movement-therapy-in-multiple-sclerosis-part-1-effects-on-real-world-function
#14
Victor W Mark, Edward Taub, Gitendra Uswatte, David M Morris, Gary R Cutter, Terrie L Adams, Mary H Bowman, Staci McKay
BACKGROUND: Constraint-Induced Movement therapy (CIMT) has controlled evidence of efficacy for improving real-world paretic limb use in non-progressive physically disabling disorders (stroke, cerebral palsy). OBJECTIVE: This study sought to determine whether this therapy can produce comparable results with a progressive disorder such as multiple sclerosis (MS). We conducted a preliminary phase II randomized controlled trial of CIMT versus a program of complementary and alternative medicine (CAM) treatments for persons with MS, to evaluate their effect on real-world disability...
March 2018: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29666970/histopathological-and-molecular-predictors-of-growth-patterns-and-recurrence-in-craniopharyngiomas-a-systematic-review
#15
REVIEW
Josephine R Coury, Brittany N Davis, Christoforos P Koumas, Giovanna S Manzano, Amir R Dehdashti
Craniopharyngiomas (CPs) are rare, benign tumors derived from Rathke's pouch, known for their high recurrence rates and associated morbidity and mortality. Despite significant investigation on risk factors for recurrence, a lack of consensus persists. Recent research suggests that specific histopathological and molecular characteristics are prognostic for disease progression. In this systematic review, we analyzed and consolidated key features of CPs that contribute to increased recurrence rates. This systematic review was performed in accordance with PRISMA guidelines...
April 17, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/29663486/calmodulin-antagonist-enhances-dr5-mediated-apoptotic-signaling-in-tra-8-resistant-triple-negative-breast-cancer-cells
#16
Romone M Fancy, Harrison Kim, Tiara Napier, Donald J Buchsbaum, Kurt R Zinn, Yuhua Song
Patients with triple negative breast cancer (TNBC) have no successful "targeted" treatment modality, which represents a priority for novel therapy strategies. Upregulated death receptor 5 (DR5) expression levels in breast cancer cells compared to normal cells enable TRA-8, a DR5 specific agonistic antibody, to specifically target malignant cells for apoptosis without inducing normal hepatocyte apoptosis. Drug resistance is a common obstacle in TRAIL-based therapy for TNBC. Calmodulin (CaM) is overexpressed in breast cancer...
April 16, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29659538/cell-adhesion-molecules-are-mediated-by-photobiomodulation-at-660-nm-in-diabetic-wounded-fibroblast-cells
#17
Nicolette N Houreld, Sandra M Ayuk, Heidi Abrahamse
Diabetes affects extracellular matrix (ECM) metabolism, contributing to delayed wound healing and lower limb amputation. Application of light (photobiomodulation, PBM) has been shown to improve wound healing. This study aimed to evaluate the influence of PBM on cell adhesion molecules (CAMs) in diabetic wound healing. Isolated human skin fibroblasts were grouped into a diabetic wounded model. A diode laser at 660 nm with a fluence of 5 J/cm² was used for irradiation and cells were analysed 48 h post-irradiation...
April 16, 2018: Cells
https://www.readbyqxmd.com/read/29619352/complementary-and-alternative-medicines-and-patients-with-breast-cancer-a-case-of-mortality-and-systematic-review-of-patterns-of-use-in-patients-with-breast-cancer
#18
REVIEW
Grayson A Roumeliotis, Genevieve Dostaler, Kirsty U Boyd
Background: The use of complementary and alternative medicines (CAMs) is common among women being treated for breast cancer. A recent mortality associated with CAM at our center precipitated a systematic review of the Cochrane, EMBASE, and PubMed databases to identify English manuscripts including "CAM" and "breast cancer." Methods: Papers included for review were selected based on predefined inclusion and exclusion criteria. The primary outcome was the use of CAM by women with breast cancer...
November 2017: Plastic Surgery
https://www.readbyqxmd.com/read/29613975/antibiotic-overuse-in-premature-low-birth-weight-infants-in-a-developing-country
#19
Maria S Rueda, Renzo Calderon-Anyosa, Jorge Gonzales, Christie G Turin, Alonso Zea-Vera, Jaime Zegarra, Sicilia Bellomo, Luis Cam, Anne Castaneda, Theresa J Ochoa
BACKGROUND: Neonatal sepsis is a leading cause of child morbidity and mortality, especially in premature and low-birth-weight (LBW) infants. Prompt antibiotic therapy is warranted, but its inappropriate use leads to bacterial resistance and adverse outcomes. Our objective is to describe the antibiotic use for late onset sepsis (LOS) in Peruvian premature infants. METHODS: Prospective study as a secondary analysis of a clinical trial in three Neonatal Care Units in Peru...
April 2, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29609944/movement-and-manual-therapy-for-adults-with-arthritis-2012-national-health-interview-survey
#20
Elise Pure, Lauren Terhorst, Nancy Baker
BACKGROUND: The use of manual therapies (chiropractic manipulation, massage) and movement therapies (yoga, tai chi) by people with arthritis may relate to their personal characteristics, and the reported emotional and physical health outcomes may differ by type of therapy. OBJECTIVES: To describe personal characteristics and predictors of manual and movement therapy use for people with arthritis, and to compare the use of manual versus movement therapy to improve physical and emotional health outcomes for people with arthritis...
April 2018: Complementary Therapies in Medicine
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