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https://www.readbyqxmd.com/read/27904489/speech-and-language-therapy-for-aphasia-following-subacute-stroke
#1
Engin Koyuncu, Pınar Çam, Nermin Altınok, Duygu Ekinci Çallı, Tuba Yarbay Duman, Neşe Özgirgin
The aim of this study was to investigate the time window, duration and intensity of optimal speech and language therapy applied to aphasic patients with subacute stroke in our hospital. The study consisted of 33 patients being hospitalized for stroke rehabilitation in our hospital with first stroke but without previous history of speech and language therapy. Sixteen sessions of impairment-based speech and language therapy were applied to the patients, 30-60 minutes per day, 2 days a week, for 8 successive weeks...
October 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27903990/baicalein-reduces-angiogenesis-in-the-inflammatory-microenvironment-via-inhibiting-the-expression-of-ap-1
#2
Yujie Huang, Zhaorui Miao, Yang Hu, Yang Yuan, Yuxin Zhou, Libin Wei, Kai Zhao, Qinglong Guo, Na Lu
Increasing clinical and experimental studies have demonstrated that refractory chronic inflammation will result in malignant tumor and anti-angiogenic therapy may be an effective way to thwart the progression. Baicalein, one of the major active flavanoids found in Scutellaria baicalensis Georgi, has been exhibited potent anti-inflammation and anti-tumor effects by reducing angiogenesis. However, the exact mechanism of baicalein on endothelial cells in inflammatory microenvironment was not clear yet. Here, we investigated the anti-angiogenic effect of baicalein by incubating human umbilical vein endothelial cells (HUVECs) with THP-1 conditioned medium in vitro...
November 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27902752/dose-dependent-dual-effect-of-baicalin-and-herb-huang-qin-extract-on-angiogenesis
#3
Dongqing Zhu, Shanshan Wang, John Lawless, Jianchen He, Zhengui Zheng
Huang Qin (root of Scutellaria baicalensis) is a widely used herb in different countries for adjuvant therapy of inflammation, diabetes, hypertension, different kinds of cancer and virus related diseases. Baicalin is the main flavonoid in this herb and has been extensively studied for 30 years. The angiogenic effect of herb Huang Qin extract and baicalin was found 13 years ago, however, the results were controversial with pro-angiogenic effect in some studies and anti-angiogenic effect in others. In this paper, the angiogenic effect of baicalin, its aglycone form baicalein and aqueous extract of Huang Qin was studied in chick embryo chorioallantoic membrane (CAM) model...
2016: PloS One
https://www.readbyqxmd.com/read/27887929/anti-vascular-inflammatory-effects-of-pentacyclic-triterpenoids-from-astilbe-rivularis-in-vitro-and-in-vivo
#4
Hyejin Kang, Sae-Kwang Ku, Jongdoo Kim, Jiwoo Chung, Sang Chan Kim, Wei Zhou, MinKyun Na, Jong-Sup Bae
Sepsis is a systemic inflammatory condition resulting from bacterial infections. It is associated with high mortality rates, and its therapeutic options are limited. Transforming growth factor β induced protein (TGFBIp) is an extracellular matrix protein that functions as a mediator of experimental sepsis. C-27-carboxylated pentacyclic triterpenoids are specifically found in species of the genus Astilbe, and show several biological effects. Given the anti-inflammatory effects of pentacyclic triterpenoids, we investigated the effects of 3β-trans-p-coumaroyloxy-olean-12-en-27-oic acid (1) and 6β-hydroxy-3-oxoolean-12-en-27-oic acid (2) on TGFBIp-mediated vascular inflammatory responses...
November 22, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27874216/complementary-and-alternative-therapies-used-by-patients-of-pediatric-dermatology-outpatient-clinics-in-turkey-a-multicenter-study
#5
Burce Can, Hülya Akan, Filiz Topaloglu Demir, Ilkin Zindanci, Filiz Cebeci, Zafer Turkoglu, Mukaddes Kavala
BACKGROUND: The aim of this study was to determine the frequency of complementary and alternative medicine (CAM) methods used in children and adolescents with chronic skin diseases, which methods parents prefer, and to what extent these methods are useful. MATERIAL AND METHODS: This cross-sectional study was conducted between June and November 2014 in patients with chronic skin diseases attending the outpatient pediatric dermatology clinics of three hospitals in Turkey...
November 22, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27864668/unproven-therapies-for-diabetes-and-their-implications
#6
REVIEW
Jothydev Kesavadev, Banshi Saboo, Shaukat Sadikot, Ashok Kumar Das, Shashank Joshi, Rajeev Chawla, Hemant Thacker, Arun Shankar, Lakshmy Ramachandran, Sanjay Kalra
Diabetes is a chronic disease and is one of the leading causes of morbidity and mortality worldwide. Being an ancient disease, many individuals follow complementary and alternative medicinal (CAM) therapies for either the cure or prevention of the disease. The popularity of these practices among the general public is in no way a testimony to their safety and efficacy. Due to the possibility of undesirable interactions with conventional medicines, it is imperative that patients are asked about CAM use during patient assessment...
November 18, 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27862978/abcc3-polymorphisms-and-mrna-expression-influence-the-concentration-of-a-carboxylic-acid-metabolite-in-patients-on-clopidogrel-and-aspirin-therapy
#7
André Ducati Luchessi, Marta Concheiro, Juliana de Freitas Germano, Vivian Nogueira Silbiger, Raul Hernandes Bortolin, Angelines Cruz, Oscar Quintela, Maria Brion, Angel Carracedo, Andres Iñiguez, Marisol Bravo, Manuel López-Rivadulla, Rosario Dominguez Crespo Hirata, Amanda Guerra Moraes Rego Sousa, Mario Hiroyuki Hirata
Acetylsalicylic acid and clopidogrel combined therapy has been reported to be beneficial in patients with acute coronary syndrome (ACS). Antiplatelet drug resistance, especially to clopidogrel, is a multifactorial phenomenon that affects a large number of ACS patients. The genetic contribution to this drug response is not fully elucidated. We investigated the relationship of ABC-type efflux subfamily C member 3 (ABCC3) polymorphisms and mRNA expression with plasma concentrations of clopidogrel, salicylic acid (SA), and a carboxylic acid metabolite (CAM)...
November 12, 2016: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27843480/prevalence-and-correlates-of-complementary-and-alternative-medicine-use-among-hypertensive-patients-in-gondar-town-ethiopia
#8
Daniel Asfaw Erku, Abebe Basazn Mekuria
Background. Complementary and alternative medicine (CAM) therapies are being widely used by hypertensive patients worldwide. However, evidences regarding CAM use by hypertensive patients in Ethiopia are limited. This study aimed at assessing prevalence and correlates of CAM use among hypertensive patients attending ambulatory clinic at Gondar University Referral Hospital (GURH), Ethiopia. Methods. A cross-sectional study was employed on 423 patients visiting GURH. Descriptive statistics and bivariate and multivariate logistic regression tools were used to analyze/come up with the prevalence and correlates of CAM use...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27815032/pharmacological-therapy-for-the-prevention-and-management-of-cardiomyopathy-in-duchenne-muscular-dystrophy-a-systematic-review
#9
Basmah El-Aloul, Luis Altamirano-Diaz, Eugenio Zapata-Aldana, Rebecca Rodrigues, Monali S Malvankar-Mehta, Cam-Tu Nguyen, Craig Campbell
Cardiomyopathy is a major source of morbidity and mortality in Duchenne muscular dystrophy (DMD) patients now that respiratory care has improved. There is currently no definitive evidence guiding the management of DMD-associated cardiomyopathy (DMD-CM). The objective of this systematic review was to evaluate the effectiveness of pharmacotherapies for the prevention and/or management of DMD-CM and to determine the optimal timing to commence these interventions. A systematic search was conducted in January 2016 using MEDLINE, EMBASE and CINAHL databases and grey literature sources for studies evaluating the use of angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers, beta-blockers or aldosterone antagonists...
October 11, 2016: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/27814735/gene-expression-profiles-and-protein-protein-interaction-networks-in-amyotrophic-lateral-sclerosis-patients-with-c9orf72-mutation
#10
Meena Kumari Kotni, Mingzhu Zhao, Dong-Qing Wei
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that involves the death of neurons. ALS is associated with many gene mutations as previously studied. In order to explore the molecular mechanisms underlying ALS with C9orf72 mutation, gene expression profiles of ALS fibroblasts and control fibroblasts were subjected to bioinformatics analysis. Genes with critical functional roles can be detected by a measure of node centrality in biological networks. In gene co-expression networks, highly connected genes called as candidate hubs have been associated with key disease-related pathways...
November 5, 2016: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/27812163/use-of-complementary-and-alternative-medicine-cam-as-part-of-the-oncological-treatment-survey-about-patients-attitude-towards-cam-in-a-university-based-oncology-center-in-germany
#11
Kerstin A Kessel, Sabrina Lettner, Carmen Kessel, Henning Bier, Tilo Biedermann, Helmut Friess, Peter Herrschbach, Jürgen E Gschwend, Bernhard Meyer, Christian Peschel, Roland Schmid, Markus Schwaiger, Klaus-Dietrich Wolff, Stephanie E Combs
INTRODUCTION: To understand if and which patients would be open-minded to Complementary and Alternative Medicine (CAM) use parallel to their oncological treatment. Moreover, we sought to determine which methods are most accepted and which are the primary motivators to use CAM. METHODS: We developed and anonymously conducted a questionnaire for patients in the oncology center (TU Munich). Questions focus on different CAM methods, previous experiences, and willingness to apply or use CAM when offered in a university-based setting...
2016: PloS One
https://www.readbyqxmd.com/read/27806639/analysis-of-the-cost-effectiveness-of-using-vonoprazan-amoxicillin-clarithromycin-triple-therapy-for-first-line-helicobacter-pylori-eradication
#12
Yusaku Kajihara, Tadashi Shimoyama, Ichiro Mizuki
BACKGROUND: Vonoprazan (VPZ)-based triple therapy has been reported to have greater efficacy than a proton pump inhibitor (PPI)-based triple therapy for Helicobacter pylori (H. pylori) eradication. However, because VPZ is more expensive than PPIs such as rabeprazole (RPZ), economic evaluation is essential. METHODS: We performed a retrospective study on 209 patients who underwent first-line eradication of H. pylori infection in Fuyoukai Murakami Hospital from 1 March 2015 to 31 March 2016...
November 3, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27802058/engineered-recognition-of-tetravalent-zirconium-and-thorium-by-chelator-protein-systems-toward-flexible-radiotherapy-and-imaging-platforms
#13
Ilya Captain, Gauthier J-P Deblonde, Peter B Rupert, Dahlia D An, Marie-Claire Illy, Emeline Rostan, Corie Y Ralston, Roland K Strong, Rebecca J Abergel
Targeted α therapy holds tremendous potential as a cancer treatment: it offers the possibility of delivering a highly cytotoxic dose to targeted cells while minimizing damage to surrounding healthy tissue. The metallic α-generating radioisotopes (225)Ac and (227)Th are promising radionuclides for therapeutic use, provided adequate chelation and targeting. Here we demonstrate a new chelating platform composed of a multidentate high-affinity oxygen-donating ligand 3,4,3-LI(CAM) bound to the mammalian protein siderocalin...
November 1, 2016: Inorganic Chemistry
https://www.readbyqxmd.com/read/27800102/the-usage-of-complementary-and-alternative-medicine-in-gastrointestinal-patients-visiting-the-outpatients-department-of-a-large-tertiary-care-centre-views-from-pakistan
#14
Ghulamullah Lail, Nasir Luck, Abbas Ali Tasneem, AyeshaAslam Rai, Syed Mudasir Laeeq, Zain Majid
INTRODUCTION: The use of complementary and alternative medicine (CAM) has increased over the last few years, and an emergent data suggests that some CAM modalities may be helpful in addressing gastrointestinal (GI) conditions. Our aim was to find out the prevalence of such practices for GI condition amongst patients visiting an OPD of a large tertiary care centre of Karachi, Pakistan. METHODS: Patients visiting outpatient department of Hepatogastroenterology department at SIUT, Pakistan from March 2014 to March 2015, were included in this cross sectional study...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27793133/the-quantity-and-quality-of-complementary-and-alternative-medicine-clinical-practice-guidelines-on-herbal-medicines-acupuncture-and-spinal-manipulation-systematic-review-and-assessment-using-agree-ii
#15
Jeremy Y Ng, Laurel Liang, Anna R Gagliardi
BACKGROUND: Complementary and alternative medicine (CAM) use is often not disclosed by patients, and can be unfamiliar to health care professionals. This may lead to underuse of beneficial CAM therapies, and overuse of other CAM therapies with little proven benefit or known contraindications. No prior research has thoroughly evaluated the credibility of knowledge-based resources. The purpose of this research was to assess the quantity and quality of CAM guidelines. METHODS: A systematic review was conducted to identify CAM guidelines...
October 29, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27790858/epidemiology-of-complementary-and-alternative-medicine-therapy-use-in-allogeneic-hematopoietic-stem-cell-transplant-survivorship-patients-in-australia
#16
Julian Lindsay, Masrura Kabir, Nicole Gilroy, Gemma Dyer, Lisa Brice, John Moore, Matthew Greenwood, Mark Hertzberg, David Gottlieb, Stephen R Larsen, Megan Hogg, Louisa Brown, Gillian Huang, Jeff Tan, Christopher Ward, Ian Kerridge
In addition to prescribed conventional medicines, many allogeneic hematopoietic stem cell transplant (HSCT) survivors also use complementary and alternative medical therapies (CAM), however, the frequency and types of CAMs used by allogeneic HSCT survivors remain unclear. Study participants were adults who had undergone an allogeneic HSCT between 1st January 2000 and 31st December 2012. Participants completed a 402-item questionnaire regarding the use of CAM, medical complications, specialist referrals, medications and therapies, infections, vaccinations, cancer screening, lifestyle, and occupational issues and relationship status following stem cell transplantation...
October 27, 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27776512/complementary-and-alternative-medicine-cam-as-part-of-primary-health-care-in-germany-comparison-of-patients-consulting-general-practitioners-and-cam-practitioners-a-cross-sectional-study
#17
Katja Krug, Katharina I Kraus, Kathrin Herrmann, Stefanie Joos
BACKGROUND: In Germany, complementary and alternative medicine (CAM) in primary health care is offered by general practitioners (GPs) and by natural health practitioners, so called 'Heilpraktiker' (HPs). Considering the steadily growing number of unregulated HPs, the aim of the study was to assess characteristics of patients consulting HPs in comparison to patients consulting GPs. METHODS: In a cross-sectional study, patients of randomly selected GPs and HPs were asked to complete a questionnaire about their health care status, health care behavior, and symptoms rated on the Measure Yourself Medical Outcome Profile (MYMOP-D)...
October 24, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27774422/complementary-and-alternative-medicine-in-indian-parkinson-s-disease-patients
#18
Awadh Kishor Pandit, Deepti Vibha, Achal Kumar Srivastava, Garima Shukla, Vinay Goyal, Madhuri Behari
Use of complementary and alternative medicine (CAM; bǔ chōng yǔ tì dài yī xué) in Parkinson disease (PD) ranged 40-70%. The objective of this study was to determine the frequency, types and factors associated with the use of CAM in Indian PD patients. PD patients, fulfilling UKPD-Society brain-bank diagnostic-criteria, attending Movement-disorders clinic of a tertiary-care teaching hospital in India from 1st May to 15th December 2012 were enrolled. Information on socio-demographic, clinical data and treatment along with factors (source of information, benefits, harms, reason for use and cost) associated with CAM use were recorded...
October 2016: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/27774413/use-of-complementary-and-alternative-medicines-among-malaysian-cancer-patients-a-descriptive-study
#19
Maryam Farooqui, Mohamed Azmi Hassali, Aishah Knight Abdul Shatar, Muhammad Aslam Farooqui, Fahad Saleem, Noman Ul Haq, Che Noriah Othman
The use of Complementary and Alternative Medicine (CAM; bǔ chōng yǔ tì dài yī xué) has been rapidly increasing among cancer patients. However, this pervasiveness is still largely unexplored among Malaysian cancer patients. The current study aimed to evaluate the patterns of CAM use among cancer patients from a local hospital in Malaysia. In addition, the study focused on the information-seeking behavior and CAM use disclosure to doctors. Of 393 patients, 184 (46.1%) had used CAM for their cancers. CAM usage was significantly associated with gender (p = 0...
October 2016: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/27771855/chloroquine-inhibits-tumor-growth-and-angiogenesis-in-malignant-pleural-effusion
#20
Qian Li, Dong-Mei Yuan, Li-Hong Ma, Chen-Hui Ma, Ya-Fang Liu, Tang-Feng Lv, Yong Song
Malignant pleural effusion (MPE) is associated with a poor prognosis in lung cancer. Currently, no effective cure exists for MPE. Chloroquine (CQ) has been demonstrated to induce vascular normalization and inhibit tumor growth. The aim of this study was to assess whether CQ affects MPE. The xenografts mice were divided into normal saline (NS), CQ, or bevacizumab (BE) group. Tumor growth and microvascular density (MVD) were monitored. We explored the effect of CQ on the proliferation, survival, and proangiogenic signaling of tumor cells in vitro...
October 22, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
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