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https://www.readbyqxmd.com/read/29151074/interferon-lambda-2-promotes-mammary-tumor-metastasis-via-angiogenesis-extension-and-stimulation-of-cancer-cell-migration
#1
R Pingwara, K Witt-Jurkowska, K Ulewicz, J Mucha, K Tonecka, Z Pilch, B Taciak, K Zabielska-Koczywas, M Mori, S Berardozzi, B Botta, T P Rygiel, M Krol
Myeloid-derived suppressor cells (MDSCs) support tumor development by stimulation of angiogenesis and immune response inhibition. In our previous study, we showed that interferon lambda 2 (IFN-λ2), secreted by MDSCs, enhances production of pro-angiogenic factors by cancer cells via phosphorylation of STAT3 and therefore promotes blood vessels formation. In the present study IFN-λ2 level was evaluated by ELISA in serum of tumor-bearing mice, whereas its expression in MDSCs isolated from the lungs with metastatic tumors and normal lungs was assessed by qPCR...
August 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29150934/the-current-status-and-perspectives-regarding-the-clinical-implication-of-intracellular-calcium-in-breast-cancer
#2
REVIEW
Amir Tajbakhsh, Alireza Pasdar, Mehdi Rezaee, Mostafa Fazeli, Saman Soleimanpour, Seyed Mahdi Hassanian, Zahra FarshchiyanYazdi, Tayebe Younesi Rad, Gordon A Ferns, Amir Avan
Calcium ions (Ca(2+) ) act as second messengers in intracellular signaling. Ca(2+) pumps, channels, sensors, and calcium binding proteins, regulate the concentrations of intracellular Ca(2+) as a key regulator of important cellular processes such as gene expression, proliferation, differentiation, DNA repair, apoptosis, metastasis, and hormone secretion. Intracellular Ca(2+) also influences the functions of several organelles, that include: the endoplasmic reticulum, mitochondria, the Golgi, and cell membrane both in normal and breast cancer cells...
November 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29122271/utilization-and-perceived-benefits-of-homeopathy-and-herbal-therapies-in-u-s-adults-implications-of-patient-centered-care
#3
Taeho Greg Rhee, Jeremy Y Ng, Jeffery A Dusek
We evaluated reasons for and perceived benefits of using homeopathic and herbal therapies in U.S. adults. Data were collected from the 2012 National Health Interview Survey, which represents non-institutionalized U.S. adults (n = 33,167 unweighted). In the past 12 months, 18.6% (41.95 million) of U.S. adults reported using either homeopathy and/or herbal therapies. Among these users, 34.8% and 5.1% used them for wellness only and treatment only, respectively. 60.1% reported using homeopathic and herbal therapies for a combination of both treatment and wellness...
November 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/29122246/nurses-knowledge-clinical-practice-and-attitude-towards-unconventional-medicine-implications-for-intercultural-healthcare
#4
Razak Mohammed Gyasi, Kabila Abass, Samuel Adu-Gyamfi, Burnett Tetteh Accam
OBJECTIVE: The aim of this hospital-based, cross-sectional study was to examine nurses' knowledge, personal and professional practices and attitude towards complementary and alternative medical therapies in urban Ghana. METHOD: Using convenience sampling technique, cross-sectional data were collected from 210 registered and practicing nurses with self-administered questionnaire based on the Complementary and Alternative Medicine (CAM) Health Belief Questionnaire (CHBQ)...
November 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/29117649/use-of-alternative-and-complementary-medicine-in-patients-with-malignant-diseases-in-high-volume-cancer-center-and-future-aspects
#5
Davor Kust, Ivan Šamija, Jasmina Marić-Brozić, Branka Svetec, Marija Miletić, Gordana Mamić, Ante Bolanča, Zvonko Kusić, Ana Fröbe
Usage of complementary and alternative medicine (CAM) is steadily increasing over the last decades, gaining medical, economic and sociological importance. The aim of the present study was to assess the use of complementary and alternative therapies in cancer patients. A cross-sectional, descriptive survey design was used to collect data through an anonymous questionnaire. A total of 267 patients were included in the study. The prevalence of CAM use among cancer patients in this study was 60.3%. It was found that 61 heterogeneous CAM therapies were used, the most popular among patients being naturopathy/folk medicine...
December 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29107312/using-complementary-and-alternative-medicine-to-treat-pain-and-agitation-in-dementia-a-review-of-randomized-controlled-trials-from-long-term-care-with-potential-use-in-critical-care
#6
REVIEW
Alison R Anderson, Jie Deng, Robert S Anthony, Sebastian A Atalla, Todd B Monroe
The risk of pain in adults with dementia worsens with advancing age. Painful comorbidities may be underassessed and inadequately treated. Receiving treatment in critical care settings may indicate greater occurrences of pain and complications. Pain may exacerbate behavioral and psychological symptoms of dementia (BPSD), such as agitation. Complementary and alternative medicine (CAM) therapies may alleviate pain and BPSD, and continuity of therapy may bolster these therapeutic effects. This review did not reveal an apparent benefit of aromatherapy; however, improvements in BPSD have been shown previously...
December 2017: Critical Care Nursing Clinics of North America
https://www.readbyqxmd.com/read/29097984/further-validation-of-the-norwegian-self-efficacy-for-therapeutic-mode-use
#7
Victoria C Ritter, Mikkel M Thørrisen, Farzaneh Yazdani, Tore Bonsaksen
Background: The Intentional Relationship Model (IRM) proposes six therapeutic modes as ways of relating to clients. The Norwegian self-efficacy for therapeutic mode use (N-SETMU) was found to have a one-component structure. However, its items reflect abstract concepts rather than concrete behaviors. Aim: To validate further the N-SETMU by linking its items to the Norwegian client assessment of modes (N-CAM), with 30 items constituting six scales (linked to each mode), possessing concrete, behavioral content...
2017: Occupational Therapy International
https://www.readbyqxmd.com/read/29096672/the-effects-of-yoga-versus-stretching-and-resistance-training-exercises-on-psychological-distress-for-people-with-mild-to-moderate-parkinson-s-disease-study-prxotocol-for-a-randomized-controlled-trial
#8
JoJo Yan Yan Kwok, Jackie Cheuk Yin Kwan, Man Auyeung, Vincent Chung Tong Mok, Helen Yue Lai Chan
BACKGROUND: Psychological distress is prevalent among people with Parkinson's disease (PD) and aggravates their motor symptoms, thereby leading to increased disability, high healthcare costs, and poor health-related quality of life (HRQoL). The under-recognition and adverse effects of the pharmacological management of anxiety and depression among the PD population are considerable. Thus, adopting a Complementary and Alternative Management (CAM) approach to address this problem is important...
November 2, 2017: Trials
https://www.readbyqxmd.com/read/29091040/a-pilot-study-to-evaluate-the-effects-of-perfusion-decellularized-porcine-hepatic-derived-wound-matrix-on-difficult-to-heal-diabetic-foot-ulcers
#9
Robert Fridman, Jonathan Engelhardt
OBJECTIVE: The purpose of this prospective pilot study is to evaluate the effects of a novel perfusion-decellularized porcine hepatic-derived wound matrix (PDPHD-WM) on very difficult-to-heal diabetic foot ulcers (DFUs). MATERIALS AND METHODS: For the intent of this study, a very difficult-to-heal DFU is one with a duration > 3 months despite using at least 1 advanced healing modality. Seven patients were enrolled in the study for a length of 14 weeks, including a 2-week run-in phase of standard-of-care therapy with saline gel and offloading in a CAM walker...
October 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29073288/complementary-and-alternative-medicine-in-brazilian-children-and-adolescents-with-type-1-diabetes-mellitus
#10
Luciana Carla Bezerra Machado, Crésio Alves
INTRODUCTION: Patients with type 1 diabetes mellitus (T1DM) resort to complementary and alternative medicine (CAM) for symptomatic relief, to inhibit progression or to reduce side effects associated with conventional therapy. OBJECTIVES: Build a profile and assess the prevalence of the use of CAM in Brazilian children and adolescents with T1DM under conventional treatment. METHODS: Cross-sectional study with interviews with the legal representatives of patients with T1DM (of both gender, aged 2- 17 years)...
2017: Pediatric Endocrinology, Diabetes, and Metabolism
https://www.readbyqxmd.com/read/29039681/complementary-and-alternative-medicine-services-in-the-military-health-system
#11
Patricia M Herman, Melony E Sorbero, Ann C Sims-Columbia
OBJECTIVES: Surveys of military personnel indicate substantial use of complementary and alternative medicine (CAM) that possibly exceeds use in the general U.S. POPULATION: Although military treatment facilities (MTFs) are known to offer CAM, surveys do not indicate where service members receive this care. This study offers a comprehensive system-wide accounting of the types of CAM offered across the military health system (MHS), the conditions for which it is used, and its level of use...
November 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29025275/complementary-and-alternative-medicine-use-in-minority-and-medically-underserved-oncology-patients-assessment-and-implications
#12
Desiree Jones, Lorenzo Cohen, Alyssa G Rieber, Diana Urbauer, Bryan Fellman, Michael J Fisch, Arlene Nazario
INTRODUCTION: Complementary and alternative medicine (CAM) use in minority and medically underserved oncology patients is not well documented. We assessed knowledge and utilization of CAM in a sample of these patients receiving treatment at an urban community hospital. METHODS: Patients with cancer were interviewed using an electronic application that depicted specific CAM therapies. Patients were questioned on their knowledge and utilization of therapies, deterrents to use, and interest in using these therapies if they were made available...
October 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29017954/low-level-led-photodynamic-therapy-using-curcumin-loaded-tetraether-liposomes
#13
Lili Duse, Shashank Reddy Pinnapireddy, Boris Strehlow, Jarmila Jedelská, Udo Bakowsky
Oncological use of photodynamic therapy is an evolving field in cancer therapeutics. Photosensitisers are prone to accumulation inside healthy tissues causing undesirable effects. To avoid this, we have developed tetraether lipid liposomal formulations containing curcumin which is a naturally occurring anti-cancer substance and deemed to be safe towards healthy cells. Upon excitation with light at a specific wavelength, curcumin produces reactive oxygen species (ROS) in presence of oxygen, thereby exhibiting a cytotoxic effect towards the surrounding tissues, giving a total control on the onset of therapy...
October 7, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28990333/a-truly-complementary-approach-a-qualitative-exploration-of-complementary-and-alternative-medicine-practitioners-views-of-treating-ankylosing-spondylitis
#14
Hannah Family, Abbie Jordan, Kelly Blaxall, Raj Sengupta
OBJECTIVE: Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease in which individuals experience a long delay to diagnosis. Prior to diagnosis, individuals report frequent use of complementary and alternative medicine (CAM) therapies. While popularly used, there is a dearth of knowledge concerning the experiences of CAM practitioners in terms of treating individuals with AS. Addressing this knowledge gap, the present study provides a detailed exploration of how UK-based CAM practitioners treat individuals with AS...
October 9, 2017: Musculoskeletal Care
https://www.readbyqxmd.com/read/28987072/adult-use-of-complementary-and-integrative-approaches-to-improve-athletic-performance
#15
Marion Willard Evans, Harrison Ndetan, Vishaldeep Ka Sekhon, Ronald Williams, Brittney Oliver, Michael Perko, Conrad Woolsey, Karan P Singh
Context • In the United States in 2007, approximately 38% of adults, or 4 in 10, used some form of complementary and alternative medicine (CAM). An area in which little is known is the personal integration of CAM therapies by those individuals seeking to improve athletic performance. Objectives • The study intended to assess the use of integrative care by adult athletes in the United States as well as their satisfaction with it, as reported in the 2012 National Health Interview Survey (NHIS). Design • A secondary analysis of the data from the Adult Alternative Health/Complementary Medicine file of the 2012 NHIS was performed...
October 2, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28976064/benefits-and-extent-of-cam-use-among-persons-living-with-hiv-attending-an-antiretroviral-therapy-clinic-in-warri-nigeria
#16
Ufuoma S Ahwinahwi, Valentine U Odili, Jeremiah Ogubere
PURPOSE: The objective of this study was to assess the use of complementary and alternative medicine (CAM) therapies among patients on anti-retroviral therapies as well as the possible reasons for their use. METHOD: This cross-sectional survey was conducted with the aid of an interviewer-administered questionnaire on HIV-positive patients attending the antiretroviral therapy clinic (Heart-to-Heart centre) of the Central Hospital, Warri, Nigeria. Patients who were 18 years and over were included after a brief introductory talk on the nature of the study...
October 4, 2017: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28975853/use-of-complementary-and-alternative-medicine-in-europe-health-related-and-sociodemographic-determinants
#17
Laura M Kemppainen, Teemu T Kemppainen, Jutta A Reippainen, Suvi T Salmenniemi, Pia H Vuolanto
AIMS: The aim of this research was to study health-related and sociodemographic determinants of the use of different complementary and alternative medicine (CAM) treatments in Europe and differences in CAM use in various European countries. METHODS: The study was based on a design-based logistic regression analysis of the European Social Survey (ESS), Round 7. We distinguished four CAM modalities: manual therapies, alternative medicinal systems, traditional Asian medical systems and mind-body therapies...
October 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28971107/food-finds-its-way-to-a-woman-s-heart-campylobacter-jejuni-associated-myopericarditis
#18
Manivannan Veerasamy, Craig T Alguire
Campylobacter jejuni-associated myopericarditis (CAM) has been reported infrequently in the literature. We describe a case of immunocompetent young woman presenting with chest pain, with history of recent travel and diarrhea. Evaluation led to diagnosis of myopericarditis associated with this infection. The patient improved with conservative management. The pathogenesis of CAM remains unknown. Patients present with chest pain, heart failure, pulmonary edema and arrhythmias. Diagnostic evaluation includes EKG, cardiac enzymes, echocardiogram, cardiac MRI and stool culture...
March 31, 2017: Global Cardiology Science & Practice
https://www.readbyqxmd.com/read/28969635/impact-of-mesenchymal-stem-cells-secretome-on-glioblastoma-pathophysiology
#19
Joana Vieira de Castro, Eduardo D Gomes, Sara Granja, Sandra I Anjo, Fátima Baltazar, Bruno Manadas, António J Salgado, Bruno M Costa
BACKGROUND: Glioblastoma (GBM) is a highly aggressive primary brain cancer, for which curative therapies are not available. An emerging therapeutic approach suggested to have potential to target malignant gliomas has been based on the use of multipotent mesenchymal stem cells (MSCs), either unmodified or engineered to deliver anticancer therapeutic agents, as these cells present an intrinsic capacity to migrate towards malignant tumors. Nevertheless, it is still controversial whether this innate tropism of MSCs towards the tumor area is associated with cancer promotion or suppression...
October 2, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28969049/cbp501-suppresses-macrophage-induced-cancer-stem-cell-like-features-and-metastases
#20
Naoki Mine, Sayaka Yamamoto, Naoya Saito, Takuji Sato, Keiichi Sakakibara, Donald W Kufe, Daniel D VonHoff, Takumi Kawabe
CBP501 is an anti-cancer drug candidate which has been shown to increase cis-diamminedichloro-platinum (II) (CDDP) uptake into cancer cell through calmodulin (CaM) inhibition. However, the effects of CBP501 on the cells in the tumor microenvironment have not been addressed. Here, we investigated new aspects of the potential anti-tumor mechanism of action of CBP501 by examining its effects on the macrophages. Macrophages contribute to cancer-related inflammation and sequential production of cytokines such as IL-6 and TNF-α which cause various biological processes that promote tumor initiation, growth and metastasis (1)...
September 8, 2017: Oncotarget
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