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https://www.readbyqxmd.com/read/28932193/safety-profile-of-anticancer-and-immune-modulating-biotech-drugs-used-in-a-real-world-setting-in-campania-region-italy-bio-cam-observational-study
#1
Cristina Scavone, Liberata Sportiello, Maria G Sullo, Carmen Ferrajolo, Rosanna Ruggiero, Maurizio Sessa, Pasquale M Berrino, Gabriella di Mauro, Liberato Berrino, Francesco Rossi, Concetta Rafaniello, Annalisa Capuano
Objectives: To investigate the occurrence of adverse events (AEs) in naïve patients receiving biotech drugs. Design: A prospective observational study. Setting: Onco-hematology, Hepato-gastroenterology, Rheumatology, Dermatology, and Neurology Units in Campania Region (Italy). Participants: 775 patients (53.81% female) with mean age 56.0 (SD 15.2). The mean follow-up/patient was 3.48 (95% confidence interval 3.13-3.84). Main outcome measures: We collected all AEs associated to biotech drugs, including serious infections and malignancies...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28927388/the-suppressive-role-of-mir-542-5p-in-nsclc-the-evidence-from-clinical-data-and-in-vivo-validation-using-a-chick-chorioallantoic-membrane-model
#2
Rong-Quan He, Xiao-Jiao Li, Lu Liang, You Xie, Dian-Zhong Luo, Jie Ma, Zhi-Gang Peng, Xiao-Hua Hu, Gang Chen
BACKGROUND: Non-small cell lung cancer (NSCLC) has led to the highest cancer-related mortality for decades. To enhance the efficiency of early diagnosis and therapy, more efforts are urgently needed to reveal the origins of NSCLC. In this study, we explored the effect of miR-542-5p in NSCLC with clinical samples and in vivo models and further explored the prospective function of miR-542-5p though bioinformatics methods. METHODS: A total of 125 NSCLC tissue samples were collected, and the expression of miR-542-5p was detected by qRT-PCR...
September 19, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28923207/eviction-from-the-sanctuary-development-of-targeted-therapy-against-cell-adhesion-molecules-in-acute-lymphoblastic-leukemia
#3
REVIEW
Sonali P Barwe, Anthony Quagliano, Anilkumar Gopalakrishnapillai
Acute lymphoblastic leukemia (ALL) is a malignant hematological disease afflicting hematopoiesis in the bone marrow. While 80%-90% of patients diagnosed with ALL will achieve complete remission at some point during treatment, ALL is associated with high relapse rate, with a 5-year overall survival rate of 68%. The initial remission failure and the high rate of relapse can be attributed to intrinsic chemoprotective mechanisms that allow persistence of ALL cells despite therapy. These mechanisms are mediated, at least in part, through the engagement of cell adhesion molecules (CAMs) within the bone marrow microenvironment...
April 2017: Seminars in Oncology
https://www.readbyqxmd.com/read/28919243/drugs-do-we-need-them-applications-of-non-pharmaceutical-therapy-in-anterior-eye-disease-a-review
#4
REVIEW
Priyanka Mandal, Mohammad A Khan, Sunil Shah
Natural products have been in use long before the introduction of modern drug therapies and are still used in various communities worldwide for the treatment of anterior eye disease. The aim of this review is to look at the current non-pharmaceutical modalities that have been tried and assess the body of existing evidence behind them. This includes alternative medicine, existing non-pharmaceutical therapy and more recent low and high tech solutions. A detailed search of all available databases including MEDLINE, Pubmed and Google was made to look for English-language studies for complementary and alternative treatment modalities (CAM), natural therapies and new modalities for anterior eye disease such as blepharitis, dry eye and microbial keratitis...
September 14, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28915523/-biologic-reconstruction-of-full-sized-cartilage-defects-of-the-hip-a-guideline-from-the-dgou-group-clinical-tissue-regeneration-and-the-hip-committee-of-the-aga
#5
Stefan Fickert, Matthias Aurich, Dirk Albrecht, Peter Angele, Lorenz Büchler, Michael Dienst, Christoph Erggelet, Jürgen Fritz, Christoph Gebhart, Hans Gollwitzer, Moritz Kindler, Christoph Lampert, Henning Madry, Gregor Möckel, Phillip Niemeyer, Jörg Schröder, Christian Sobau, Gunter Spahn, Wolfgang Zinser, Stefan Landgraeber
Background Symptomatic pre-arthritic deformities such as femoroacetabular impingement (FAI) or hip dysplasia often lead to localised cartilage defects and subsequently to osteoarthritis. The present review of the working group "Clinical Tissue Regeneration" of the German Society of Orthopaedics and Trauma (DGOU) and the hip committee of the AGA (German speaking Society for Arthroscopy and Joint Surgery) provides an overview of current knowledge of the diagnosis and surgical treatment of cartilage defects, in order to infer appropriate therapy recommendations for the hip...
September 15, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28912904/fasciatherapy-and-reflexology-compared-to-hypnosis-and-music-therapy-in-daily-stress-management
#6
Bernard Payrau, Nadine Quere, Elisabeth Breton, Christine Payrau
BACKGROUND: Patients suffering from stress symptoms due to every-day life who are looking for a non-pharmacological response to their relief expectation are many. Furthermore, early reckoning of the day-to-day stress which may lead to clinical diagnosis is the best way of preventing the stress-related diseases. Among the many alternative medicinal options, there is little evidence that fasciatherapy (Fs) and reflexology (Rf) are effective in this field. PURPOSE: assess incidence of fasciatherapy Danis Bois Method (DBM) and of reflexology on patients' stress level in everyday-life, and provide a more informed choice among the numerous mind and body techniques by comparing them with hypnosis (Hp) and music therapy (Mt)...
September 2017: International Journal of Therapeutic Massage & Bodywork
https://www.readbyqxmd.com/read/28912824/prevalence-and-correlates-of-complementary-and-alternative-medicine-use-among-patients-with-lung-cancer-a-cross-sectional-study-in-beirut-lebanon
#7
Farah Naja, Bilal Anouti, Hibeh Shatila, Reem Akel, Yolla Haibe, Arafat Tfayli
Patients with lung cancer are increasingly seeking complementary and alternative medicine (CAM) to improve their physiological and psychological well-being. This study aimed to assess CAM use among lung cancer patients in Lebanon. Using a cross-sectional design, 150 lung cancer patients attending the Basile Cancer Institute at the American University of Beirut Medical Center were interviewed. Participants completed a questionnaire addressing sociodemographic characteristics, lung cancer condition, and use of CAM...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28898555/complementary-and-alternative-medicine-in-u-s-adults-with-diabetes-reasons-for-use-and-perceived-benefits
#8
Taeho Greg Rhee, Sarah M Westberg, Ila M Harris
OBJECTIVES: While complementary and alternative medicine (CAM) is increasingly used, little is known about reasons for CAM use (treatment, wellness or both) and self-reported perceived benefits among U.S. adults with diabetes at the national level. We estimated prevalence rates of overall and specific types of CAM by reason for use, and examined perceived benefits of using CAM by reason for use among U.S. adults with diabetes. METHODS: We used cross-sectional data from the 2012 National Health Interview Survey, which represents non-institutionalized adults with diabetes (n = 3,386 unweighted)...
September 12, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28894606/corneal-nerve-regeneration-after-self-retained-cryopreserved-amniotic-membrane-in-dry-eye-disease
#9
Thomas John, Sean Tighe, Hosam Sheha, Pedram Hamrah, Zeina M Salem, Anny M S Cheng, Ming X Wang, Nathan D Rock
PURPOSE: To evaluate the efficacy of self-retained cryopreserved amniotic membrane (CAM) in promoting corneal nerve regeneration and improving corneal sensitivity in dry eye disease (DED). METHODS: In this prospective randomized clinical trial, subjects with DED were randomized to receive CAM (study group) or conventional maximum treatment (control). Changes in signs and symptoms, corneal sensitivity, topography, and in vivo confocal microscopy (IVCM) were evaluated at baseline, 1 month, and 3 months...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28891959/the-pi3k%C3%AE-inhibitor-idelalisib-inhibits-homing-in-an-in-vitro-and-in-vivo-model-of-b-all
#10
Etai Adam, Hye Na Kim, Eun Ji Gang, Caitlin Schnair, Solomon Lee, Solah Lee, Sajad Khazal, Osanna Kosoyan, Marina Konopleva, Chintan Parekh, Deepa Bhojwani, Alan S Wayne, Hisham Abdel-Azim, Nora Heisterkamp, Yong-Mi Kim
The quest continues for targeted therapies to reduce the morbidity of chemotherapy and to improve the response of resistant leukemia. Adhesion of acute lymphoblastic leukemia (ALL) cells to bone marrow stromal cells triggers intracellular signals that promote cell-adhesion-mediated drug resistance (CAM-DR). Idelalisib, an U.S. Food and Drug Administration (FDA)-approved PI3Kδ-specific inhibitor has been shown to be effective in CLL in down-regulating p-Akt and prolonging survival in combination with Rituximab; herein we explore the possibility of its use in B ALL and probe the mechanism of action...
September 10, 2017: Cancers
https://www.readbyqxmd.com/read/28888499/the-efficacy-of-art-therapy-in-pediatric-oncology-patients-an-integrative-literature-review
#11
REVIEW
Bree A Aguilar
PROBLEM: Children undergoing cancer treatment experience detrimental adverse side effects that may be addressed with complementary and alternative medicine (CAM) such as art therapy. The purpose of this research was to examine the effects of art therapy in pediatric patients living with cancer. ELIGIBILITY CRITERIA: An integrative literature review was conducted using the CINAHL, OVID Medline, and PsycINFO databases. Studies were included if they were a primary source utilizing an art therapy intervention in children with cancer age birth to 18years old, was published between the year 2000 and 2016, and written in the English language...
September 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28883702/doublecortin-and-cam-kinase-like-1-as-an-independent-prognostic-factor-in-patients-with-resected-pancreatic-carcinoma
#12
Kohei Nishio, Kenjiro Kimura, Ryosuke Amano, Bunzo Nakata, Sadaaki Yamazoe, Go Ohira, Kotaro Miura, Naoki Kametani, Hiroaki Tanaka, Kazuya Muguruma, Kosei Hirakawa, Masaichi Ohira
AIM: To elucidate the effect of expression of doublecortin and CaM kinase-like-1 (DCLK1) in patients with pancreatic ductal adenocarcinoma (PDAC). METHODS: Tumor specimens were obtained from 136 patients with pancreatic cancer who had undergone resection without preoperative therapy between January 2000 and December 2013 at the Department of Surgical Oncology, Osaka City University. The resected specimens were analyzed for associations with clinicopathological data, including DCLK1 expression, epithelial mesenchymal transition (EMT) marker expression, and cancer stem cell (CSC) marker expression...
August 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28881299/photo-responsive-tetraether-lipids-based-vesicles-for-prophyrin-mediated-vascular-targeting-and-direct-phototherapy
#13
Gihan Mahmoud, Jarmila Jedelská, Boris Strehlow, Samia Omar, Marc Schneider, Udo Bakowsky
Tetraether lipids (TELs) derived from the thermoacidophilic archaeon Sulfolobus acidocaldarius are dominated by polyisoprenoid skeleton. The unique molecular stability of TELs is attributed to the presence of cyclopentane rings, methyl side groups and sugar residues that create extensive hydrogen bond network. In addition, the presence of ether linkages and the lacking of double bonds make them an epitome candidate for photodynamic therapy (PDT). A subtle blend of formulation design to trigger efficient photo responses of protoporphyrin IX (PpIX) exploiting TELs was developed...
August 30, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28877524/selection-paradigms-for-large-vessel-occlusion-acute-ischemic-stroke-endovascular-therapy
#14
Mehdi Bouslama, Meredith T Bowen, Diogo C Haussen, Seena Dehkharghani, Jonathan A Grossberg, Letícia C Rebello, Srikant Rangaraju, Michael R Frankel, Raul G Nogueira
BACKGROUND: Optimal patient selection methods for thrombectomy in large vessel occlusion stroke (LVOS) are yet to be established. We sought to evaluate the ability of different selection paradigms to predict favorable outcomes. METHODS: Review of a prospectively collected database of endovascular patients with anterior circulation LVOS, adequate CT perfusion (CTP), National Institutes of Health Stroke Scale (NIHSS) ≥10 from September 2010 to March 2016. Patients were retrospectively assessed for thrombectomy eligibility by 4 mismatch criteria: Perfusion-Imaging Mismatch (PIM): between CTP-derived perfusion defect and ischemic core volumes; Clinical-Core Mismatch (CCM): between age-adjusted NIHSS and CTP core; Clinical-ASPECTS Mismatch (CAM-1): between age-adjusted NIHSS and ASPECTS; Clinical-ASPECTS Mismatch (CAM-2): between NIHSS and ASPECTS...
September 7, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28876080/cancer-impact-complementary-alternative-medicine-beliefs-and-quality-of-life-in-cancer-patients
#15
Ya-Hui Kuo, Shiow-Luan Tsay, Chun-Chi Chang, Yen-Chi Liao, Heng-Hsin Tung
OBJECTIVES: The purpose of this study was to explore the relationships among cancer impact, belief in complementary and alternative medicine (CAM), CAM use, and quality of life (QOL). DESIGN: The study used a cross-sectional, descriptive correlational design with convenience sampling. A total of 122 cancer patients participated. Data were collected at a medical center in Chunghua, Taiwan. The questionnaires included the Chinese version of the Cancer Problem in Living Scale (CPILS), Complementary and Alternative Medicine Belief Inventory (CAMBI), Complementary and Alternative Medicine scale, and Chinese versions of QOL scales, including the Functional Assessment of Cancer Therapy-General (FACT-G)...
September 6, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28867756/successful-treatment-with-clarithromycin-and-or-tacrolimus-for-two-patients-with-polymyalgia-rheumatica
#16
Masashi Ohe, Haruki Shida, Tetsuya Horita, Kenji Oku
Polymyalgia rheumatica (PMR) is an inflammatory rheumatic disease in the elderly. Glucocorticoids (GCs) remain the mainstay of treatment. GC therapy usually dramatically improves the clinical picture, but approximately one-third of patients experience disease recurrence when the dose is reduced. Moreover, long-term use of GCs causes adverse reactions. Macrolide antibiotics have anti-inflammatory action. Several recent studies have reported the successful treatment of rheumatoid arthritis (RA) and PMR treated using clarithromycin (CAM), a macrolide, because of its anti-inflammatory action...
2017: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/28866745/mortality-and-prognostic-factors-in-idiopathic-inflammatory-myositis-a-retrospective-analysis-of-a-large-multicenter-cohort-of-spain
#17
Laura Nuño-Nuño, Beatriz Esther Joven, Patricia E Carreira, Valentina Maldonado-Romero, Carmen Larena-Grijalba, Irene Llorente Cubas, Eva Gloria Tomero, María Carmen Barbadillo-Mateos, Paloma García De la Peña Lefebvre, Lucía Ruiz-Gutiérrez, Juan Carlos López-Robledillo, Henry Moruno-Cruz, Ana Pérez, Tatiana Cobo-Ibáñez, Raquel Almodóvar González, Leticia Lojo, María Jesús García De Yébenes, Francisco Javier López-Longo
The present study was undertaken to assess mortality, causes of death, and associated prognostic factors in a large cohort of patients diagnosed with idiopathic inflammatory myositis (IIM) from Spain. A retrospective longitudinal study was carried out in 467 consecutive patients with IIM, identified from 12 medical centers. Patients were classified as primary polymyositis, primary dermatomyositis (DM), overlap myositis, cancer-associated myositis (CAM), and juvenile idiopathic inflammatory myopathies. A total of 113 deaths occurred (24%) after a median follow-up time of 9...
September 2, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28865300/technical-feasibility-of-personalized-articulating-knee-joint-distraction-for-treatment-of-tibiofemoral-osteoarthritis
#18
T Struik, J E N Jaspers, N J Besselink, P M van Roermund, S Plomp, M J Rudert, F P J G Lafeber, S C Mastbergen
BACKGROUND: Knee osteoarthritis is a highly prevalent degenerative joint disorder characterized by joint tissue damage and pain. Knee joint distraction has been introduced as a joint preserving surgical procedure to postpone knee arthroplasty. An often used standard externally fixation device for distraction poses a burden to patients due to the absence of joint flexion during the 6weeks treatment. Therefore, a personalized articulating distraction device was developed. The aim of this study was to test technical feasibility of this device...
August 12, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28860442/-effective-bird-therapy-after-the-addition-of-clarithromycin-for-lenalidomide-and-dexamethasone-resistant-multiple-myeloma-ineligible-for-stem-cell-transplantation
#19
Shogo Miura, Hiroyuki Kuroda, Michiko Yamada, Ken Sato, Saki Ameda, Hiroya Sakano, Takanori Shibata, Naoki Uemura, Tomoyuki Abe, Shigeyuki Fujii, Masahiro Maeda, Masayoshi Kobune, Junji Kato
BiRd combination therapy, which comprises clarithromycin(CAM: Biaxin®), lenalidomide(LEN: Revlimid®), and dexamethasone( DEX), is a highly effective treatment for newly diagnosed symptomatic multiple myeloma(MM). However, its efficacy against recurrent myeloma refractory to LEN and DEX combination therapy(Rd therapy)remains unclear. In this study, we retrospectively analyzed the data of 7 patients(4 men and 3 women, median age of 76 years)with MM, who had clarithromycin added to their Rd regimen. In all patients, the starting dose of clarithromycin was 400 mg daily and the median number of prior therapies was 3(range, 1-4)...
August 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28852777/-clostridium-difficile-associated-deaths-from-2013-2016-in-munich-and-nuremberg-reporting-behavior-and-patient-characteristics
#20
REVIEW
Sabine Gleich, Alice Schaffer, Cam Hong Mai, Sylvia Schick, Bertrand Hirl
BACKGROUND: A number of risk factors for C. difficile infection (CDI) are described in the literature, in particular an antibiotic therapy 4-6 weeks before disease, an age of >65 years, immunosuppression and living in a long-term care facility. Increasing incidence rates have been reported for Germany. CDI is the fourth most common nosocomial infection with 6.4%. AIM: Due to the amendment of the Infection Protection Act of 01.05.2016, the proportion of all deaths that are C...
August 29, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
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