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https://www.readbyqxmd.com/read/28534381/evaluation-of-complementary-and-alternative-medicine-trials-registered-in-clinicaltrials-gov-database
#1
Omer Dizdar, Emre Bilgin, Serkan Akin, Saadettin Kilickap, Mutlu Hayran
PURPOSE: Complementary and alternative medicine (CAM) products are increasingly used because they are perceived as natural, relatively low-cost and probably effective therapies for various diseases including cancer. We aimed to determine the quantity and major characteristics of recent herbal/alternative medicine trials registered in clinicaltrials. gov in patients with cancer. METHODS: "Cancer AND (herbal OR complementary OR alternative)" key words were used to query clinicaltrials...
March 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28533307/sox11-promotes-tumor-protective-microenvironment-interactions-through-cxcr4-and-fak-regulation-in-mantle-cell-lymphoma
#2
Patricia Balsas, Jara Palomero, Álvaro Eguileor, Marta Leonor Rodriguez, Maria Carmela Vegliante, Ester Planas-Rigol, Marta Sureda-Gómez, Maria C Cid, Elias Campo, Virginia Amador
SOX11 overexpression in Mantle Cell Lymphoma (MCL) has been associated with more aggresive behavior and worse outcome. However, SOX11 oncogenic pathways driving MCL tumor progression are poorly known. Here, we demonstrate that SOX11 binds to regulatory regions of two important genes for microenvironment-signals in cancer, (C-X-C motif) chemokine receptor 4 (CXCR4) and PTK2 (encoding for focal adhesion kinase (FAK)). Moreover, SOX11-positive xenograft and human primary MCL tumors overexpress cell migration and stromal stimulation gene signatures compared to their SOX11-negative counterparts...
May 22, 2017: Blood
https://www.readbyqxmd.com/read/28532114/hypocrellin-b-and-nano-silver-loaded-polymeric-nanoparticles-enhanced-generation-of-singlet-oxygen-for-improved-photodynamic-therapy
#3
Subramanian Natesan, Venkateshwaran Krishnaswami, Chandrasekar Ponnusamy, Madi Madiyalakan, Thomas Woo, Rajaguru Palanisamy
A nanoparticulate photodynamic approach was employed with an objective to achieve enhanced production of singlet oxygen ((1)O2), for the management of posterior segment eye diseases like age related macular degeneration. The hypocrellin B (HB) loaded poly lactide-co-glycolide nanoparticle formulations were incorporated with nano silver (HBS-NPs). The optimized HBS-NPs contained 2.60±0.06mg/mL of HB and showed (i) 135.6 to 828.2nm size range, and (ii) negative zeta potential with a narrow polydispersity index...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28526079/patient-needs-and-preferences-for-herb-drug-disease-interaction-alerts-a-structured-interview-study
#4
Carrie M Christensen, Rebecca S Morris, Seraphine Chepkemoi Kapsandoy, Melissa Archer, Jinqiu Kuang, Laura Shane-McWhorter, Bruce E Bray, Qing Zeng-Treitler
BACKGROUND: While complementary and alternative medicine (CAM) is commonly used in the United States and elsewhere, and hazardous interactions with prescription drugs can occur, patients do not regularly communicate with physicians about their CAM use. The objective of this study was to discover patient information needs and preferences for herb-drug-disease interaction alerts. METHODS: We recruited 50 people from several locations within the University of Utah Hospital to participate in this structured interview study...
May 19, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28524619/use-of-complementary-and-alternative-medicines-is-associated-with-delay-to-initiation-of-disease-modifying-anti-rheumatic-drug-therapy-in-early-inflammatory-arthritis
#5
Manjari Lahiri, Amelia Santosa, Lay Kheng Teoh, Jane A Clayton, Sheen Yee Lim, Gim Gee Teng, Peter P M Cheung
OBJECTIVES: To study the predictors of complementary and alternative medicine (CAM) use in patients with early inflammatory arthritis (EIA), and its impact on delay to initiation of disease-modifying anti-rheumatic drugs (DMARD). METHODS: Data were collected prospectively from EIA patients aged ≥ 21 years. Current or prior CAM use was ascertained by face-to-face interview. Predictors of CAM use and its effect on time to DMARD initiation were determined by multivariate logistic regression and Cox proportional hazards, respectively...
May 19, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28512119/complementary-and-integrative-medicine-in-the-management-of-headache
#6
REVIEW
Denise Millstine, Christina Y Chen, Brent Bauer
Headaches, including primary headaches such as migraine and tension-type headache, are a common clinical problem. Complementary and integrative medicine (CIM), formerly known as complementary and alternative medicine (CAM), uses evidence informed modalities to assist in the health and healing of patients. CIM commonly includes the use of nutrition, movement practices, manual therapy, traditional Chinese medicine, and mind-body strategies. This review summarizes the literature on the use of CIM for primary headache and is based on five meta-analyses, seven systematic reviews, and 34 randomized controlled trials (RCTs)...
May 16, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28506257/an-overview-of-systematic-reviews-of-complementary-and-alternative-therapies-for-fibromyalgia-using-both-amstar-and-robis-as-quality-assessment-tools
#7
Rachel Perry, Verity Leach, Philippa Davies, Chris Penfold, Andy Ness, Rachel Churchill
BACKGROUND: Fibromyalgia (FM) is a chronic, debilitating pain disorder. Dissatisfaction with conventional medicine can lead people with FM to turn to complementary and alternative medicine (CAM). Two previous overviews of systematic reviews of CAM for FM have been published, but they did not assessed for risk of bias in the review process. METHODS: Five databases Medline, Embase, AMED (via OVID), Web of Science and Central were searched from their inception to December 2015...
May 15, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28494011/changes-in-the-use-practitioner-based-complementary-and-alternative-medicine-over-time-in-canada-cohort-and-period-effects
#8
Mayilee Canizares, Sheilah Hogg-Johnson, Monique A M Gignac, Richard H Glazier, Elizabeth M Badley
BACKGROUND: The use of complementary and alternative medicine (CAM) is growing. However the factors contributing to changes over time and to birth cohort differences in CAM use are not well understood. SETTING: We used data from 10186 participants, who were aged 20-69 years at the first cycle of data collection in the longitudinal component of the Canadian National Population Health Survey (1994/95-2010/11). We examined chiropractic and other practitioner-based CAM use with a focus on five birth cohorts: pre-World War II (born 1925-1934); World War II (born 1935-1944); older baby boomers (born 1945-1954); younger baby boomers (born 1955-1964); and Gen Xers (born 1965-1974)...
2017: PloS One
https://www.readbyqxmd.com/read/28489574/targeting-neurokinin-3-receptor-a-novel-anti-angiogenesis-strategy-for-cancer-treatment
#9
Ting Wang, Siwei Chen, Shihui Wang, Liang Shi, Chenggong Wang, Jingxin Zhang, Yanfeng Gao, Guodong Li, Yuanming Qi, Xiuli An, Lixiang Chen
Angiogenesis is essential for tumor growth and metastasis, controlling angiogenesis is a promising strategy in cancer treatment. However, thus farther severe side effects of anti-angiogenic drugs have been rather demonstrated, stimulating interest in seeking novel targets of anti-angiogenesis. Neurokinin receptors, also known as tachykinin receptors, are usually considered as drug targets due to diverse physiological functions and their tractability. Although Neurokinin B, the selective natural agonist of neurokinin-3 receptor, have been shown to exhibit anti-angiogenesis activity, the effect and mechanism of neurokinin-3 receptor-mediated angiogenesis still remains unclear...
April 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28476530/enriching-gene-expression-profiles-will-help-personalize-prostate-cancer-management-for-african-americans-a-perspective
#10
REVIEW
Srinivasan Vijayakumar, John C Henegan, Xu Zhang, Wanmei Wang, William A Day, Vani Vijayakumar, Carlos S Moreno, Christian R Gomez
Prostate cancer (PCa) remains the most common form of cancer affecting men in the Western Hemisphere. Mortality rate is 130% higher among African-American men (AAM) than Caucasian-American men. As this trend is not new nor changing, there is an urgent need to identify markers with the ability to specifically distinguish aggressive PCa in the context of race. Gene expression patterns have been used as a tool to identify prognostic biomarkers for PCa to help reduce this disparity. Gene expression profiles reveal molecular mechanisms useful in understanding the biologic basis of tumorigenesis...
May 2, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28476053/transmission-of-donor-derived-breast-carcinoma-as-a-recurrent-mass-in-a-keratolimbal-allograft
#11
Audra K Miller, Jonathan W Young, David J Wilson, Jennifer Dunlap, Winston Chamberlain
PURPOSE: To report a case of local transmission of invasive lobular carcinoma from a donor to a recipient in a keratolimbal allograft after cessation of systemic immunosuppressive therapy. METHODS: This is a case report including the clinicopathologic findings. Sections of the donor breast tumor and recipient conjunctival lesions were stained with hematoxylin and eosin. Immunohistochemical studies were performed using pancytokeratin, CK7, CK20, CAM 5.2, CD138, TTF1, estrogen receptor, progesterone receptor, GATA-3, GCDFP-15, and mammaglobin...
June 2017: Cornea
https://www.readbyqxmd.com/read/28472987/use-of-complementary-and-alternative-medicine-by-patients-with-end-stage-renal-disease-on-haemodialysis-in-trinidad-a-descriptive-study
#12
Mandreker Bahall
BACKGROUND: Despite the paucity of scientific evidence, complementary and alternative medicine (CAM) is widely used for the prevention and treatment of illness, holistic care, and counteracting the adverse effects of conventional medicine (CM). This study investigates the use of CAM by patients with end-stage renal disease (ESRD) on haemodialysis. METHODS: This quantitative study was conducted from November 1, 2014 to December 31, 2014 in the haemodialysis unit at San Fernando General Hospital (San Fernando, Trinidad)...
May 4, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28465164/fluorescence-analysis-of-a-tumor-model-in-the-chorioallantoic-membrane-used-for-the-evaluation-of-different-photosensitizers-for-photodynamic-therapy
#13
Hilde Harb Buzzá, Amanda C Zangirolami, Arthur Davis, Pablo A Gómez-García, Cristina Kurachi
The development of a tumor in the chicken chorioallantoic membrane (CAM) enables a more individualized understanding of the dynamics of the photosensitizer (PS) interaction with the tumor blood vessels and cells. Photogem(®) and 5-aminolevulinic acid (ALA), a protoporphyrin IX (PpIX) precursor, were used as PS and their red fluorescence enabled the monitoring of PS dynamic distribution in the vessels and in the tumor. With a tumor model in CAM and fluorescence assessment, the aim of this study was to evaluate the PDT parameters comparing different photosensitezers...
April 29, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28446137/progressive-cutaneous-cryptococcosis-complicated-with-meningitis-in-a-myasthenia-gravis-patient-on-long-term-immunosuppressive-therapy-a-case-report
#14
Nguyen Thi Cam Huong, Ahmed M A Altibi, Nguyen My Hoa, Le Anh Tuan, Samar Salman, Sara Morsy, Nguyen Thi Bich Lien, Nguyen Thanh Truong, Nguyen Thi Hoang Mai, Pham Thi Le Hoa, Nguyen Ba Thang, Van The Trung
BACKGROUND: Cryptococcosis is an opportunistic infection caused by the encapsulated yeast Cryptococcus neoformans and most remarkably manifests in HIV-infected individuals, especially in the settings of very low CD4 count. Development of cryptococcosis in HIV-uninfected individuals is exceedingly rare and usually signifies a marked immunodeficiency. Cryptococcosis in association with myasthenia gravis or thymoma has been previously documented in only very few cases in the literature. CASE PRESENTATION: We reported a complicated case of severe cutaneous cryptococcosis in a 39-year-old Vietnamese male patient with myasthenia gravis on long-term immunosuppressive therapy...
April 26, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28438278/complementary-and-alternative-medicine-cam-among-australian-hospital-based-nurses-knowledge-attitude-personal-and-professional-use-reasons-for-use-cam-referrals-and-socio-demographic-predictors-of-cam-users
#15
Seyed Afshin Shorofi, Paul Arbon
OBJECTIVE: This study was intended to examine CAM among Australian hospital-based nurses, identifying their knowledge, attitude, personal and professional use, reasons for use, CAM referrals, and socio-demographic predictors of CAM users. METHODS AND MATERIALS: Nurses holding a qualification in nursing and working in surgical wards were included using a convenience sampling technique. A self-complete questionnaire was developed to achieve the aims of the study. Descriptive and non-parametric statistics were calculated to describe and analyse data...
May 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/28434471/factors-associated-with-complementary-medicine-use-in-pediatric-musculoskeletal-conditions-results-from-a-national-survey
#16
Ezra M Cohen, Michelle L Dossett, Darshan H Mehta, Roger B Davis, Yvonne C Lee
OBJECTIVES: Complementary and alternative medicine (CAM) use is common in children, but its use has only been investigated in children with musculoskeletal conditions (MSK) to a limited extent. We aimed to characterize factors associated with CAM use in children with MSK conditions. METHODS: Within the 2012 National Health Interview Survey dataset (including its child CAM supplement), we examined factors associated with CAM use in children with MSK conditions and performed an analysis examining the perceived usefulness of CAM therapies for MSK conditions...
April 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28425415/drug-induced-liver-injury-at-a-tertiary-hospital-in-india-etiology-clinical-features-and-predictors-of-mortality
#17
Chetan Rathi, Nirav Pipaliya, Ruchir Patel, Meghraj Ingle, Aniruddha Phadke, Prabha Sawant
INTRODUCTION AND AIMS: Drug-induced liver injury (DILI) is rare; however, it is one of the important causes of acute liver failure which results in significant morbidity or mortality. MATERIAL AND METHODS: Patients with suspected DILI were enrolled based on predefined criteria and followed up for at least 6 months or until normalization of liver tests. Causality assessment was done by applying the Roussel Uclaf Causality Assessment Method model. RESULTS: We collected data from 82 individuals diagnosed with DILI at our hospital from 2014 through 2015 (41 men; median age, 38 years)...
May 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28421118/pattern-of-traditional-medicine-utilization-among-hiv-aids-patients-on-antiretroviral-therapy-at-a-university-hospital-in-northwestern-ethiopia-a-cross-sectional-study
#18
Abyot Endale Gurmu, Fitsum Sebsibe Teni, Wondmagegn Tamiru Tadesse
The objective of this study was to assess traditional, complementary, and alternative medicine (TCAM) utilization pattern among HIV/AIDS patients on antiretroviral therapy at University of Gondar Comprehensive Specialized Hospital. Materials and Methods. Data on sociodemographic profile and clinical and TCAM utilization were collected using a structured, pretested questionnaire from April 01 to May 28, 2014, through interviews with patients. Data on CD4 count, HIV stage, and ART regimen were collected from patient records...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28420427/isolation-and-characterization-of-equine-native-msc-populations
#19
Cristina L Esteves, Tara A Sheldrake, Simone P Mesquita, Juan J Pesántez, Timothy Menghini, Lucy Dawson, Bruno Péault, F Xavier Donadeu
BACKGROUND: In contrast to humans in which mesenchymal stem/stromal cell (MSC) therapies are still largely in the clinical trial phase, MSCs have been used therapeutically in horses for over 15 years, thus constituting a valuable preclinical model for humans. In human tissues, MSCs have been shown to originate from perivascular cells, namely pericytes and adventitial cells, which are identified by the presence of the cell surface markers CD146 and CD34, respectively. In contrast, the origin of MSCs in equine tissues has not been established, preventing the isolation and culture of defined cell populations in that species...
April 18, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28417094/contemporary-acupressure-therapy-adroit-cure-for-painless-recovery-of-therapeutic-ailments
#20
REVIEW
Piyush Mehta, Vishwas Dhapte, Shivajirao Kadam, Vividha Dhapte
Since time immemorial, complementary and alternative medicines (CAM) have played a significant role in human health care. CAM is known to have a strong reputation and reliability within every culture to provide basic health care treatment for patients. CAM acts as a better therapeutic option in human being for treating various diseases and improving quality of life with apt consideration to the economic aspects. Acupressure, one of the known CAM, originated in ancient China is based on the principal of acupoints activation across the meridians which correct the imbalance between Qi...
April 2017: Journal of Traditional and Complementary Medicine
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