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https://www.readbyqxmd.com/read/28212560/use-of-complementary-and-alternative-medicine-cam-in-cancer-patients-an-italian-multicenter-survey
#1
Massimiliano Berretta, Chiara Della Pepa, Paolo Tralongo, Alberto Fulvi, Ferdinando Martellotta, Arben Lleshi, Guglielmo Nasti, Rossella Fisichella, Carmela Romano, Chiara De Divitiis, Rosaria Taibi, Francesco Fiorica, Raffaele Di Francia, Anna Di Mari, Lino Del Pup, Anna Crispo, Paolo De Paoli, Adriano Santorelli, Vincenzo Quagliariello, Rosario Vincenzo Iaffaioli, Umberto Tirelli, Gaetano Facchini
INTRODUCTION: Complementary and Alternative Medicine (CAM) include a wide range of products (herbs, vitamins, minerals, and probiotics) and medical practices, developed outside of the mainstream Western medicine. Patients with cancer are more likely to resort to CAM first or then in their disease history; the potential side effects as well as the costs of such practices are largely underestimated. PATIENTS AND METHOD: We conducted a descriptive survey in five Italian hospitals involving 468 patients with different malignancies...
December 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/28212381/complementary-and-alternative-medicine-for-the-treatment-of-bronchiolitis-in-infants-a-systematic-review
#2
Kok Pim Kua, Shaun Wen Huey Lee
BACKGROUND: Bronchiolitis is a common cause of hospitalization among infants. The limited effectiveness of conventional medication has prompted the use of complementary and alternative medicine (CAM) as alternative or adjunctive therapy for the management of bronchiolitis. AIMS: To determine the effectiveness and safety of CAM for the treatment of bronchiolitis in infants aged less than 2 years. METHODS: A systematic electronic search was performed in Medline, Embase, CINAHL, AMED, and Cochrane Central Register of Controlled Trials (CENTRAL) from their respective inception to June 30, 2016 for studies evaluating CAM as an intervention to treat bronchiolitis in infants (1 month to 2 years of age)...
2017: PloS One
https://www.readbyqxmd.com/read/28210516/immunohistochemical-investigation-of-her-akt-mtor-pathway-and-cellular-adhesion-molecules-in-urothelial-carcinomas
#3
Nikolaos Koletsas, Triantafyllia Koletsa, Spyros Choidas, Konstantinos Anagnostopoulos, Stavros Touloupidis, Thomas Zaramboukas, Georgia Raptou, Nikolaos Papadopoulos, Maria Lambropoulou
Background. Several investigators have suggested the possibility that the expression of both EGFR and HER2 could be utilized for molecularly targeted therapy in urinary bladder cancer. We tried to evaluate the expression of HER2 and EGFR and activation of the AKT/PTEN/mTOR pathway in urothelial carcinomas and if there is any association between them and cellular adhesion molecules (CAMs). Materials and Methods. Forty-one paraffin-embedded urothelial cancer tissue blocks were collected. Immunostains for HER2, EGFR, MIB1, phospho-AKT, PTEN, phospho-mTOR, e-cadherin, p-cadherin, and b-catenin were performed on tissue microarrays sections...
2017: Pathology Research International
https://www.readbyqxmd.com/read/28194552/a-novel-synthetic-small-molecule-yf-452-inhibits-tumor-growth-through-antiangiogenesis-by-suppressing-vegf-receptor-2-signaling
#4
Yongrui Liu, Yuan He, Feifei Yang, Xiaonan Cong, Jinhua Wang, Shihong Peng, Dan Gao, Weifang Wang, Liping Lan, Xuexiang Ying, Mingyao Liu, Yihua Chen, Zhengfang Yi
Tumor angiogenesis is characterized by abnormal vessel morphology, endowing tumor with highly hypoxia and unresponsive toward treatment. To date, mounting angiogenic factors have been discovered as therapeutic targets in antiangiogenic drug development. Among them, vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors exerts potent antiangiogenic activity in tumor therapy. Therefore, it may provide a valid strategy for cancer treatment through targeting the tumor angiogenesis via VEGFR2 pathway...
February 13, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28177661/anti-inflammatory-effects-of-dabrafenib-in-vitro-and-in-vivo
#5
In-Chul Lee, Jongdoo Kim, Jong-Sup Bae
The screening of bioactive compound libraries can be an effective approach for repositioning FDA-approved drugs or discovering new treatments for human diseases (drug repositioning). Drug repositioning refers to the development of existing drugs for new indications. Dabrafenib (DAB) is a B-Raf inhibitor and initially used for the treatment of metastatic melanoma therapy. Here, we tested the possible use of DAB in the treatment of lipopolysaccharide (LPS)-mediated vascular inflammatory responses. The anti-inflammatory activities of DAB were determined by measuring permeability, neutrophils adhesion and migration, and activation of pro-inflammatory proteins in LPS-activated human umbilical vein endothelial cells (HUVECs) and mice...
February 3, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28174300/calmodulin-lobes-facilitate-dimerization-and-activation-of-estrogen-receptor-%C3%AE
#6
Zhigang Li, Yonghong Zhang, Andrew C Hedman, James B Ames, David B Sacks
Estrogen receptor alpha (ER-α) is a nuclear hormone receptor that controls selected genes, thereby regulating proliferation and differentiation of target tissues, such as breast. Gene expression controlled by ER-α is modulated by Ca2+ via calmodulin (CaM). Here we present the NMR structure of Ca2+-CaM bound to two molecules of ER-α (residues 287-305). The two lobes of CaM bind to the same site on two separate ER-α molecules (residues 292, 296, 299, 302 and 303), which explains why CaM binds two molecules of ER-α in a 1:2 complex and stabilizes ER-α dimerization...
February 7, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28138194/efficacy-and-safety-concerns-regarding-complementary-and-alternative-medicine-use-among-diabetes-patients
#7
Jothydev Kesavadev
There has been an ever increasing rise in the use of Complementary and Alternative Medicinal (CAM) practices among general populations during past few decades. Individuals with diabetes being prone to an array of related health complications, demand special attention concerning their interest towards different CAM practices. Apart from clinical practitioner and patient based awareness programmes regarding the safety and efficacy implications of CAM therapies, stringent regulations should also be imposed on these unconventional health practices so as to strike off any major adverse events...
February 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28130601/complementary-and-alternative-medicine-in-radiation-oncology-survey-of-patients-attitudes
#8
Sabrina Lettner, Kerstin A Kessel, Stephanie E Combs
BACKGROUND: Complementary and alternative medicine (CAM) are gaining in importance, but objective data are mostly missing. However, in previous trials, methods such as acupuncture showed significant advantages compared to standard therapies. Thus, the aim was to evaluate most frequently used methods, their significance and the general acceptance amongst cancer patients undergoing radiotherapy (RT). METHODS: A questionnaire of 18 questions based on the categorical classification released by the National Centre for Complementary and Integrative Health was developed...
January 27, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28129399/long-term-course-of-failed-back-surgery-syndrome-fbss-patients-receiving-integrative-korean-medicine-treatment-a-1-year-prospective-observational-multicenter-study
#9
Jinho Lee, Joon-Shik Shin, Yoon Jae Lee, Me-Riong Kim, Areum Choi, Jun-Hwan Lee, Kyung-Min Shin, Byung-Cheul Shin, Jae-Heung Cho, In-Hyuk Ha
BACKGROUND: With increase of spine surgeries, failed back surgery syndrome (FBSS) prevalence is also rising. While complementary and alternative medicine (CAM) is commonly used for low back pain (LBP), there are no studies reporting use of integrative Korean medicine in FBSS patients. METHODS: Patients with pain continuing after back surgery or recurring within 1 year and visual analogue scale (VAS) of LBP or leg pain of ≥6 (total n = 120) were recruited at 2 hospital sites from November 2011 to September 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28126581/a-controlled-comparison-trial-of-the-collaborative-assessment-and-management-of-suicidality-cams-in-an-inpatient-setting-outcomes-at-discharge-and-six-month-follow-up
#10
Thomas E Ellis, Katrina A Rufino, Jon G Allen
This controlled comparison trial evaluated a suicide-specific intervention, the Collaborative Assessment and Management of Suicidality (CAMS), in an extended-stay psychiatric inpatient setting. Multiple outcomes were examined for 104 patients, half of whom received individual therapy from therapists trained in CAMS. The comparison group was selected from a larger pool through Propensity Score Matching to ensure comparability on age, sex, treatment program, number of prior suicide attempts, and severity of suicidal ideation...
January 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28112683/blood-pressure-associated-polymorphism-controls-arhgap42-expression-via-serum-response-factor-dna-binding
#11
Xue Bai, Kevin D Mangum, Rachel A Dee, George A Stouffer, Craig R Lee, Akinyemi Oni-Orisan, Cam Patterson, Jonathan C Schisler, Anthony J Viera, Joan M Taylor, Christopher P Mack
We recently demonstrated that selective expression of the Rho GTPase-activating protein ARHGAP42 in smooth muscle cells (SMCs) controls blood pressure by inhibiting RhoA-dependent contractility, providing a mechanism for the blood pressure-associated locus within the ARHGAP42 gene. The goals of the current study were to identify polymorphisms that affect ARHGAP42 expression and to better assess ARHGAP42's role in the development of hypertension. Using DNase I hypersensitivity methods and ENCODE data, we have identified a regulatory element encompassing the ARHGAP42 SNP rs604723 that exhibits strong SMC-selective, allele-specific activity...
February 1, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28112554/inpatients-preferences-beliefs-and-stated-willingness-to-pay-for-complementary-and-alternative-medicine-treatments
#12
Lori P Montross-Thomas, Emily A Meier, Kimberly Reynolds-Norolahi, Erin E Raskin, Daniel Slater, Paul J Mills, Lauray MacElhern, Gene Kallenberg
OBJECTIVES: Research demonstrates the benefits of complementary and alternative medicine (CAM) in myriad environments. Yet, the majority of CAM services are offered in outpatient settings. Incorporating CAM into hospital settings may lead to increased patient comfort, well-being, and overall satisfaction with hospital admissions. Few studies have examined CAM services among inpatients. Therefore, this study assessed inpatients' preferences and beliefs regarding CAM, as well as their stated willingness to pay for these services...
January 23, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28108911/traditional-chinese-medicine-for-modern-treatment-of-parkinson-s-disease
#13
REVIEW
Lu Han, Yuan-Hong Xie, Rong Wu, Chen Chen, Yan Zhang, Xiao-Ping Wang
Parkinson's disease (PD) is a chronic and progressive degenerative disorder of brain commonly seen among the elderly. As conventionally medical therapy is of limited relief and potential side effects, complementary and alternative medicine (CAM) has attracted growing public and professional attention. Therapies such as acupuncture, musical/rhythmic therapy and deep brain stimulation have been gradually proved positively in clinic. In this review, we retrospected the scientific or evidence-based-medicine advances of application and research for modern treatment of PD by CAM, especially traditional Chinese medicine in categories...
January 20, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28107845/usage-of-complementary-and-alternative-medicine-a-survey-among-indian-dental-professionals
#14
M Suganya, M Vikneshan, U Swathy
OBJECTIVE: CAM therapies are used along with standard medical care. Though there are various medical evidences to prove the effectiveness of CAM therapies in managing medical problems, the evidence for the dental application are still lacking in India. This could be attributed to the non-availability or the insufficient knowledge regarding the use of CAM in dentistry. Hence it is necessary to obtain the baseline knowledge regarding the use of CAM therapies among dentists. METHOD: Cross sectional questionnaire based survey...
February 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/28104436/capsaicin-synergizes-with-camptothecin-to-induce-increased-apoptosis-in-human-small-cell-lung-cancers-via-the-calpain-pathway
#15
Jamie R Friedman, Haley E Perry, Kathleen C Brown, Ying Gao, Ju Lin, Cathyrn D Stevenson, John D Hurley, Nicholas A Nolan, Austin T Akers, Yi Charlie Chen, Krista L Denning, Linda G Brown, Piyali Dasgupta
Small cell lung cancer (SCLC) is characterized by excellent initial response to chemotherapy and radiation therapy with a majority of the patients showing tumor shrinkage and even remission. However, the challenge with SCLC therapy is that patients inevitably relapse and subsequently do not respond to the first line treatment. Recent clinical studies have investigated the possibility of camptothecin-based combination therapy as first line treatment for SCLC patients. Conventionally, camptothecin is used for recurrent SCLC and has poor survival outcomes...
January 16, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28098886/novel-zinc-phthalocyanine-as-a-promising-photosensitizer-for-photodynamic-treatment-of-esophageal-cancer
#16
Weronika Kuzyniak, Jacob Schmidt, Wojciech Glac, Janine Berkholz, Gustav Steinemann, Björn Hoffmann, Eugeny A Ermilov, Ayşe Gül Gürek, Vefa Ahsen, Bianca Nitzsche, Michael Höpfner
Photodynamic therapy (PDT) has gathered much attention in the field of cancer treatment and is increasingly used as an alternative solution for esophageal cancer therapy. However, there is a constant need for improving the effectiveness and tolerability of the applied photosensitizers (PS). Here, we propose tetra-triethyleneoxysulfonyl substituted zinc phthalocyanine (ZnPc) as a promising PS for photodynamic treatment of esophageal cancer. ZnPc-induced phototoxicity was studied in two human esophageal cancer cell lines: OE-33 (adenocarcinoma) and Kyse-140 (squamous cell carcinoma)...
January 17, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28088780/national-survey-of-china-s-oncologists-knowledge-attitudes-and-clinical-practice-patterns-on-complementary-and-alternative-medicine
#17
Geliang Yang, Richard Lee, Huiqing Zhang, Wei Gu, Peiying Yang, Changquan Ling
It is common for cancer patients to use complementary and alternative medicine (CAM). This study was designed to explore China's oncologists' knowledge, attitudes and clinical practices regarding CAM use by their patients. An online survey was conducted of China's oncologists. Among 11,270 participants who completed the online survey, 6,007 (53.3%) were identified as oncologists. Most were men (75.2%), with a mean age of 33.4 (standard deviation: 6.5) years. The 6,007 oncologists discussed with 36.5% of their patients about CAM...
January 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28086934/electroacupuncture-plus-moxibustion-therapy-for-patients-with-major-depressive-disorder-study-protocol-for-a-randomized-controlled-trial
#18
Mikyung Kim, Eun-Ji Choi, Sung-Phil Kim, Jung-Eun Kim, Hyo-Ju Park, Ae-Ran Kim, Bok-Nam Seo, O-Jin Kwon, Jung Hyo Cho, Sun-Yong Chung, Joo-Hee Kim
BACKGROUND: Major depressive disorder (MDD) is one of the most prevalent mental health disorders and has a significant societal economic burden. Antidepressants and cognitive behavioral therapy are two primary interventions for the standardized treatment of MDD. However, their weaknesses, such as a low response rate, a high risk of adverse events from medication, and the high cost of cognitive behavioral therapy, have resulted in a need for complementary and alternative medicine (CAM)...
January 13, 2017: Trials
https://www.readbyqxmd.com/read/28068355/a-methodology-for-cancer-therapeutics-by-systems-pharmacology-based-analysis-a-case-study-on-breast-cancer-related-traditional-chinese-medicines
#19
Yan Li, Jinghui Wang, Feng Lin, Yinfeng Yang, Su-Shing Chen
Breast cancer is the most common carcinoma in women. Comprehensive therapy on breast cancer including surgical operation, chemotherapy, radiotherapy, endocrinotherapy, etc. could help, but still has serious side effect and resistance against anticancer drugs. Complementary and alternative medicine (CAM) may avoid these problems, in which traditional Chinese medicine (TCM) has been highlighted. In this section, to analyze the mechanism through which TCM act on breast cancer, we have built a virtual model consisting of the construction of database, oral bioavailability prediction, drug-likeness evaluation, target prediction, network construction...
2017: PloS One
https://www.readbyqxmd.com/read/28065908/ticagrelor-but-not-clopidogrel-active-metabolite-displays-antithrombotic-properties-in-the-left-atrial-endocardium
#20
Martin F Reiner, Alexander Breitenstein, Erik W Holy, Martina Glanzmann, Heidi Amstalden, Simon F Stämpfli, Nicole R Bonetti, Volkmar Falk, Stephan Keller, Gianluigi Savarese, Stefano Benussi, Francesco Maisano, Thomas F Lüscher, Jürg H Beer, Jan Steffel, Giovanni G Camici
AIMS: Oral anticoagulation is considered standard therapy for stroke prevention in atrial fibrillation (AF). Endocardial activation triggers expression of pro-thrombotic mediators including tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1), and contributes to thrombus formation in the left atrial appendage (LAA) of AF patients. Recently, pleiotropic effects of specific P2Y12 receptor antagonists were demonstrated; however, whether these drugs possess antithrombotic effects on LAA endocardial cells currently remains unknown...
January 8, 2017: European Heart Journal
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