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Genome-Wide Association Study of Plasma N6 Polyunsaturated Fatty Acids within the CHARGE Consortium.
Weihua Guan, Brian T Steffen, Rozenn N Lemaitre, Jason H Y Wu, Toshiko Tanaka, Ani Manichaikul, Millennia Foy, Stephen S Rich, Lu Wang, Jennifer A Nettleton, Weihong Tang, Xiangjun Gu, Stafania Bandinelli, Irena B King, Barbara McKnight, Bruce M Psaty, David Siscovick, Luc Djousse, Yii-Der Ida Chen, Luigi Ferrucci, Myriam Fornage, Dariush Mozafarrian, Michael Y Tsai, Lyn M Steffen
BACKGROUND: Omega-6 (n6) polyunsaturated fatty acids (PUFAs) and their metabolites are involved in cell signaling, inflammation, clot formation, and other crucial biological processes. Genetic components, such as variants of fatty acid desaturase (FADS) genes, determine the composition of n6 PUFAs. METHODS AND RESULTS: To elucidate undiscovered biologic pathways that may influence n6 PUFA composition, we conducted genome-wide association studies and meta-analyses of associations of common genetic variants with five plasma n6 PUFAs in 8,631 Caucasian adults (55% female) across five prospective studies...
June 2014: Circulation. Cardiovascular Genetics
#2
JOURNAL ARTICLE
Weihua Guan, Brian T Steffen, Rozenn N Lemaitre, Jason H Y Wu, Toshiko Tanaka, Ani Manichaikul, Millennia Foy, Stephen S Rich, Lu Wang, Jennifer A Nettleton, Weihong Tang, Xiangjun Gu, Stafania Bandinelli, Irena B King, Barbara McKnight, Bruce M Psaty, David Siscovick, Luc Djousse, Yii-Der Ida Chen, Luigi Ferrucci, Myriam Fornage, Dariush Mozafarrian, Michael Y Tsai, Lyn M Steffen
BACKGROUND: Omega6 (n6) polyunsaturated fatty acids (PUFAs) and their metabolites are involved in cell signaling, inflammation, clot formation, and other crucial biological processes. Genetic components, such as variants of fatty acid desaturase (FADS) genes, determine the composition of n6 PUFAs. METHODS AND RESULTS: To elucidate undiscovered biological pathways that may influence n6 PUFA composition, we conducted genome-wide association studies and meta-analyses of associations of common genetic variants with 6 plasma n6 PUFAs in 8631 white adults (55% women) across 5 prospective studies...
June 2014: Circulation. Cardiovascular Genetics
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