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https://www.readbyqxmd.com/read/29677217/optimisation-of-three-dimensional-lower-jaw-resection-margin-planning-using-a-novel-black-bone-magnetic-resonance-imaging-protocol
#1
Astrid M Hoving, Joep Kraeima, Rutger H Schepers, Hildebrand Dijkstra, Jan Hendrik Potze, Bart Dorgelo, Max J H Witjes
BACKGROUND: MRI is the optimal method for sensitive detection of tumour tissue and pre-operative staging in oral cancer. When jawbone resections are necessary, the current standard of care for oral tumour surgery in our hospital is 3D virtual planning from CT data. 3D printed jawbone cutting guides are designed from the CT data. The tumour margins are difficult to visualise on CT, whereas they are clearly visible on MRI scans. The aim of this study was to change the conventional CT-based workflow by developing a method for 3D MRI-based lower jaw models...
2018: PloS One
https://www.readbyqxmd.com/read/29676690/does-size-matter-investigating-the-optimal-planning-target-volume-margin-for-postoperative-stereotactic-radiosurgery-to-resected-brain-metastases
#2
Jaymin Jhaveri, Mudit Chowdhary, Xinyan Zhang, Robert H Press, Jeffrey M Switchenko, Matthew J Ferris, Tiffany M Morgan, Justin Roper, Anees Dhabaan, Eric Elder, Bree R Eaton, Jeffrey J Olson, Walter J Curran, Hui-Kuo G Shu, Ian R Crocker, Kirtesh R Patel
OBJECTIVE The optimal margin size in postoperative stereotactic radiosurgery (SRS) for brain metastases is unknown. Herein, the authors investigated the effect of SRS planning target volume (PTV) margin on local recurrence and symptomatic radiation necrosis postoperatively. METHODS Records of patients who received postoperative LINAC-based SRS for brain metastases between 2006 and 2016 were reviewed and stratified based on PTV margin size (1.0 or > 1.0 mm). Patients were treated using frameless and framed SRS techniques, and both single-fraction and hypofractionated dosing were used based on lesion size...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29676343/histopathological-report-of-colorectal-carcinoma-resections-a-5-year-audit-in-lagos
#3
Kabir Bolarinwa Badmos, Olorunda Rotimi, Abdulrazzaq Oluwagbemiga Lawal, Adedapo O Osinowo, Mohammed Y Habeebu, Fatimah Biade Abdulkareem
Background: Complete and accurate pathology reporting of colorectal carcinoma (CRC) resection specimen is critical to clinical management of individual patients. The study aims to audit colorectal cancer histopathology reporting in Lagos between 2011 and 2015 before the adoption of the Society for Gastroenterology and Hepatology in Nigeria pro forma in 2016. Materials and Methods: All resected CRC cases were identified from the Histopathology record of our Department and that of a private Laboratory in Lagos over a 5-year from 2011 to 2015...
January 2018: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29675938/value-of-additional-endoscopic-ultrasonography-for-surveillance-after-surgical-removal-of-intraductal-papillary-mucinous-neoplasms
#4
Ken Kamata, Mamoru Takenaka, Kosuke Minaga, Shunsuke Omoto, Takeshi Miyata, Kentaro Yamao, Hajime Imai, Atsushi Nakai, Hidekazu Tanaka, Yasutaka Chiba, Tomohiro Watanabe, Toshiharu Sakurai, Naoshi Nishida, Takaaki Chikugo, Ippei Matsumoto, Yoshifumi Takeyama, Masayuki Kitano, Masatoshi Kudo
BACKGROUND AND AIMS: This study evaluated the utility of endoscopic ultrasonography (EUS), combined with contrast-enhanced harmonic EUS (CH-EUS), for surveillance of the remnant pancreas after surgery for intraductal papillary mucinous neoplasm (IPMN). METHODS: This was a single-center, retrospective, descriptive study. A total of 134 consecutive patients who underwent surgical resection for IPMN between April 2009 and March 2015 were evaluated. The rates of recurrence and development of IPMN-concomitant pancreatic ductal adenocarcinoma (PDAC) during follow-up were assessed...
April 19, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29672305/the-prognostic-prediction-role-of-preoperative-serum-albumin-level-in-patients-with-intahepatic-cholangiocarcinoma-following-hepatectomy
#5
Junyi Shen, Tianfu Wen, Chuan Li, Lvnan Yan, Bo Li, Jiayin Yang
BACKGROUND: There is little information regarding the role of preoperative serum albumin (ALB) in intrahepatic cholangiocarcinoma (ICC) patients who underwent liver resection. METHODS: Clinicopathological characteristics and survival rate of 91 ICC patients who underwent surgery between 2009 and 2013 were included in this study. The optimal cut-off for ALB were determined by plotting the receiver operating characteristics curves of ALB in predicting overall survival (OS) and utilizing the Youden index...
April 19, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29668968/outcomes-of-endoscopic-resections-of-large-laterally-spreading-colorectal-lesions-in-inflammatory-bowel-disease-a-single-united-kingdom-center-experience
#6
Shraddha Gulati, Andrew Emmanuel, Margaret Burt, Patrick Dubois, Bu'Hussain Hayee, Amyn Haji
Background: The SCENIC consensus statement recommends endoscopic resection of all visible dysplasia in inflammatory bowel disease, but patients with large or complex lesions may still be advised to have colectomy. This article presents outcomes for large nonpolypoid resections associated with colitis at our institution. Methods: Data including demographics, clinical history, lesion characteristics, method of resection, and postresection surveillance were collected prospectively in patients with visible lesions within colitic mucosa from January 2011 to November 2016...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29668413/pancreatic-adenocarcinoma-staging-in-the-era-of-preoperative-chemotherapy-and-radiation-therapy
#7
Marc Zins, Celso Matos, Christophe Cassinotto
Pancreatic ductal adenocarcinoma (PDA) remains among the most challenging malignancies to treat. At diagnosis, the tumor often already extends beyond the confines of the pancreas, spreading to an extent such that primary surgery with curative intent is very rarely feasible. Considerable momentum is now being given to a treatment strategy involving neoadjuvant chemotherapy or chemotherapy and radiation therapy in patients with nonmetastatic PDA. The main advantage of this strategy is better selection of patients likely to benefit from curative-intent surgery through the achievement of negative resection margins...
May 2018: Radiology
https://www.readbyqxmd.com/read/29665118/locoregionally-advanced-oral-cavity-cancer-a-propensity-score-matched-analysis-on-overall-survival-with-emphasis-on-the-impact-of-adjuvant-radiotherapy
#8
Jacob Y Shin, Ja Kyoung Yoon, Aaron K Shin, Aidnag Z Diaz
BACKGROUND: The purpose of this study was to determine the impact of adjuvant radiotherapy (RT) in locoregionally advanced oral cavity cancer. METHODS: Data were extracted from the National Cancer Data Base, of which overall survival (OS) is the only outcome variable available. The chi-square test and Cox regression models were used. RESULTS: A total of 6654 patients were identified. The utilization of adjuvant RT has increased over time. A propensity matched cohort included 3946 patients, exactly one-half of whom received adjuvant RT...
April 17, 2018: Head & Neck
https://www.readbyqxmd.com/read/29663302/multivisceral-resection-for-locally-advanced-gastric-and-gastroesophageal-junction-cancers-11-year-experience-at-a-high-volume-north-american-center
#9
J C Molina, A Al-Hinai, A Gosseling-Tardif, P Bouchard, J Spicer, D Mulder, C L Mueller, L E Ferri
INTRODUCTION: The oncologic benefit of multivisceral en bloc resections for T4 gastroesophageal tumors has been questioned, given the increased morbidity associated. We thus sought to investigate the surgical and oncologic outcomes of curative-intent en bloc multivisceral resections for T4 gastroesophageal carcinomas. METHODS: Between 2005 and 2016, 35 of the 525 patients who had gastric or EGJ carcinomas underwent curative-intent multivisceral resections for direct invasion or adhesion to adjacent organs...
April 16, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29659435/frontalis-muscle-flap-versus-maximal-anterior-levator-resection-as-first-option-for-patients-with-severe-congenital-ptosis
#10
Ramón Medel, Salvador Molina, Luz Maria Vasquez, Josep Visa, Ana Wert, Charlotte Wolley-Dod
PURPOSE: To compare 2 surgical techniques (frontalis flap versus maximal anterior levator resection) as first surgical options for the treatment of congenital ptosis with poor levator function in patients younger than 2 years of age with a follow up of 10 years. METHODS: A retrospective study of 58 patients (71 eyelids) with severe ptosis and poor levator function who underwent frontalis muscle flap (FMF = 47) or maximal anterior levator resection (ALR = 24) for correction of their ptosis...
April 12, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29658649/challenges-associated-with-the-pathological-diagnosis-of-colorectal-tumors-less-than-10-mm-in-size
#11
REVIEW
Shin Ichihara, Toshio Uraoka, Shiro Oka
Various techniques including cold snare polypectomy and endoscopic mucosal resection are used for the removal of small colorectal polyps. Specimens of resected polyps are prepared in pathology laboratories and analyzed to make a pathological diagnosis. However, reports on how different resection methods influence the pathological diagnosis are limited. This article discusses the problems associated with the failure of polyp retrieval and fragmentation of small specimens during collection and the effects of certain parameters on the pathological diagnosis, particularly with regard to surgical margins...
April 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29658593/laterally-spreading-features-of-gastrointestinal-stromal-tumors-a-clinicopathological-study
#12
Susumu Matsukuma, Michinori Murayama, Yoshitaka Utsumi, Koji Sumi, Kosuke Miyai, Hiroaki Takeo
To elucidate the histopathological features of laterally spreading gastrointestinal stromal tumors (GISTs), we retrospectively examined 52 GISTs grossly completely resected from 50 patients. Laterally spreading features were identified in 7 GISTs (13%), and were localized within non‑thickened regions of the muscularis propria adjacent to the main GISTs, ranging in length from 0.12 to 0.7 cm (mean, 0.3 cm). The laterally spreading features involved the muscular surgical margins in 2 cases. The morphologies of the laterally spreading cells resembled those of tumor cells in 4 cases, but were comprised of more slender spindle cells with smaller nuclei compared with those in the respective main GISTs...
April 10, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29657889/pre-operative-versus-post-operative-radiosurgery-for-brain-metastasis-effects-on-treatment-volume-and-inter-observer-variability
#13
B A Vellayappan, J Doody, E Vandervoort, J Szanto, J Sinclair, J M Caudrelier, S Malone
Purpose/Objectives: Compared to post-operative whole brain radiotherapy, resection cavity radiosurgery reduces impact on neuro-cognitive function and improves quality-of-life. However, coverage of the operative tract, in addition to tumour bed, may lead to large treatment volumes and inter-observer variability. We hypothesized that pre-operative radiosurgery reduces target volume size and inter-observer variability compared to post-operative radiosurgery. Materials/Methods: We identified 10 consecutive patients, with solitary brain metastasis, treated with post-operative cavity radiosurgery...
2018: Journal of Radiosurgery and SBRT
https://www.readbyqxmd.com/read/29657707/abdominal-tattoo-can-be-useful-to-avoid-a-midline-abdominal-incision
#14
Jose' F Velasquez, Gisella Nele, Salvatore Giordano
We report a case in which abdominal tattoo margins were modified and used to hide the surgical incision for desmoid tumour removal. Our patient is a 37-year-old female with history remarkable for atrial septal defect closure at the age of ten, but not for previous abdominal surgeries or trauma. A desmoid tumour diagnosis was made upon needle biopsy of the 5 × 4 cm2 mass confined to the rectus abdominis. Subsequently, tumour was resected with an incision through the tattoo upper margin and abdominal wall was reconstructed with primary fascial closure mesh reinforced...
April 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29657063/does-previous-transanal-excision-for-early-rectal-cancer-impair-surgical-outcomes-and-pathologic-findings-of-completion-total-mesorectal-excision-results-of-a-systematic-review-of-the-literature
#15
Y Eid, A Alves, J Lubrano, B Menahem
BACKGROUND: Transanal excision (TAE) is increasingly used in the treatment of early rectal cancer because of lower rate of both postoperative complications and postsurgical functional disorders as compared with total mesorectal excision (TME) OBJECTIVE: To compare in a meta-analysis surgical outcomes and pathologic findings between patients who underwent TAE followed by completion proctectomy with TME (TAE group) for early rectal cancer with unfavorable histology or incomplete resection, and those who underwent primary TME (TME group)...
April 12, 2018: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/29651788/sphincter-preserving-surgery-for-recurrent-pelvic-malignancy-using-a-hybrid-procedure-of-open-laparotomy-and-transanal-endoscopic-approach
#16
Seiji Ishiguro, Shunichiro Komatsu, Kenichi Komaya, Takuya Saito, Takashi Arikawa, Kenichiro Kaneko, Tsuyoshi Sano
BACKGROUND: Surgery for the treatment of recurrent pelvic malignancy is challenging. Sphincter-preserving surgery (SPS) has been applied in limited cases. Transanal endoscopic approach (TEA) has been used for primary rectal cancer, predominantly for hybrid transabdominal-transanal total mesorectal excision. Here, we describe the use of TEA as a hybrid approach in a case of recurrent ovarian cancer. CASE PRESENTATION: A 59-year-old woman had recurrence of serous ovarian adenocarcinoma in the vaginal stump, near the site of anastomosis from a rectal resection 18 months previously...
April 12, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29651577/pathological-margin-clearance-and-survival-after-pancreaticoduodenectomy-in-a-us-and-european-pancreatic-center
#17
Stijn van Roessel, Gyulnara G Kasumova, Omidreza Tabatabaie, Sing Chau Ng, L Bengt van Rijssen, Joanne Verheij, Robert M Najarian, Thomas M van Gulik, Marc G Besselink, Olivier R Busch, Jennifer F Tseng
BACKGROUND: The optimal definition of a margin-negative resection and its exact prognostic significance on survival in resected pancreatic adenocarcinoma remains unknown. This study was designed to assess the relationship between pathological margin clearance, margin type, and survival. METHODS: Patients who underwent pancreaticoduodenectomy with curative intent at two academic institutions, in Amsterdam, the Netherlands, and Boston, Massachusetts, between 2000 and 2014 were retrospectively evaluated...
April 12, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29651576/fluorescence-molecular-imaging-and-tomography-of-matrix-metalloproteinase-activatable-near-infrared-fluorescence-probe-and-image-guided-orthotopic-glioma-resection
#18
Li Li, Yang Du, Xinjian Chen, Jie Tian
PURPOSE: Malignant gliomas are major causes of cancer-related mortality and morbidity. Traditional surgery usually leads to incomplete resection of gliomas resulting in the high incidence of tumor recurrence. Advanced medical imaging technology, such as fluorescence imaging-guided surgery, combined with tumor-specific imaging probes allows the identification of tumor margins and improved surgery. However, there are two pressing issues that need to be addressed: first, few fluorescence imaging probes can specifically target gliomas; second, fluorescence molecular imaging (FMI) cannot get the in-depth information of deep-seated gliomas; both of which affect the complete removal of the gliomas...
April 12, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29651026/development-of-a-mouse-model-for-the-visual-and-quantitative-assessment-of-lymphatic-trafficking-and-function-by-in-vivo-imaging
#19
Yoshihisa Yamaji, Shinsuke Akita, Hidetaka Akita, Naoya Miura, Masaki Gomi, Ichiro Manabe, Yoshitaka Kubota, Nobuyuki Mitsukawa
Methods for quantitative analysis of long distance lymphatic transport of nanoparticles in live animals are yet to be established. We established a mouse model for analysis of time-dependent transport just beneath the abdominal skin to investigate lymph node-to-lymph node trafficking by in vivo imaging. For this purpose, popliteal lymph nodes (PLNs) as well as efferent and afferent lymphatic vessels, marginal veins, and feeding blood vessels were surgically resected to change the lymphatic flow from footpad injections...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29650925/-a-case-of-colon-cancer-with-brain-liver-and-lung-metastasis-successfully-treated-with-bevacizumab-plus-xelox-therapy
#20
Tomokazu Tokoro, Keishi Nakamura, Atsushi Hirose, Shinichi Nakanuma, Kohichi Okamoto, Jun Kinoshita, Isamu Makino, Hironori Hayashi, Katsunobu Oyama, Tomoharu Miyashita, Hidehiro Tajima, Hiroyuki Takamura, Itasu Ninomiya, Sachio Fushida, Tetsuo Ohta
The patient was a 57-year-old woman. Preclinical examination of malignant lymphoma revealed 0-I sp type of early rectal cancer in the upper rectum, 20 cm from the anal margin. Endoscopic mucosal resection was performed and positive deep margins were pathologically diagnosed. Additional intestinal resection with lymph node dissection was deemed necessary, but ABVD therapy was initiated because the clinical stage of the malignant lymphoma was Stage III b or higher. Two months after detecting elevated CEA, S8 liver metastasis was pointed out, and examination of weakness of the right upper limb revealed nodular, multifocal brain metastasis...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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