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https://www.readbyqxmd.com/read/28455982/comparisons-of-short-term-and-survival-outcomes-of-laparoscopy-assisted-versus-open-total-gastrectomy-for-gastric-cancer-patients
#1
Xin-Zu Chen, Shao-Yong Wang, Yin-Su Wang, Zi-Han Jiang, Wei-Han Zhang, Kai Liu, Kun Yang, Xiao-Long Chen, Lin-Yong Zhao, Meng Qiu, Hong-Feng Gou, Zong-Guang Zhou, Jian-Kun Hu
OBJECTIVES: The safety and surgical oncology of laparoscopy-assisted total gastrectomy (LATG) remain inconclusive and challenging. This study aimed to compare the short-term and long-term outcomes between LATG and open total gastrectomy (OTG) procedures. RESULTS: In the all-included analyses, there were 69 patients in the LATG group and 268 in the OTG group. LATG was as safe as OTG without increasing postoperative morbidity and mortality. Stage imbalance might introduce differences in the numbers of harvested lymph nodes in LATG (34...
April 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28455835/surgical-approaches-in-hereditary-endocrine-tumors
#2
REVIEW
Maurizio Iacobone, Marilisa Citton, Giovanni Viel, Donatella Schiavone, Francesca Torresan
Endocrine tumors of thyroid, adrenal and parathyroid glands may be due to germline and inheritable mutations in 5-30% of patients. Medullary Thyroid Carcinoma, Pheochromocytoma, Paraganglioma, and Familial Primary Hyperparathyroidism are the most frequent entity. Hereditary endocrine tumors usually have a suggestive familial history; they occur earlier than sporadic variants, are multifocal, and have increased recurrence rates. They may be present as isolated variant or associated to other neoplasms in a syndromic setting...
April 28, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28455818/analysis-of-fatty-acids-in-mouse-tissue-via-in-situ-transmethylation-with-biochar
#3
Jechan Lee, Yiu Fai Tsang, Jeong-Ik Oh, Seokmann Hong, Changsung Kim, Eilhann E Kwon
Lipid derivatization technology-mediated fatty acid profiling studies have been suggested to dissect the contents of lipids in white fat and brown fat tissue. The focus of this study is to profile fatty acid lipidomics in brown adipose tissue and white adipose tissue of mice by derivatizing their lipids into fatty acid methyl esters via in situ transmethylation using a rice husk-derived biochar as porous media. The in situ transmethylation using biochar is advantageous in biological analysis because there was no loss of samples inevitably occurring in the loss of lipid in solvent extraction and purification steps...
April 28, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28455802/gastroesophageal-reflux-disease-after-laparoscopic-sleeve-gastrectomy-with-concomitant-hiatal-hernia-repair-an-unresolved-question
#4
Hanaa Dakour Aridi, Mohammad Asali, Tarek Fouani, Ramzi S Alami, Bassem Y Safadi
PURPOSE: The effectiveness of the concomitant repair of hiatal hernia (HHR) during laparoscopic sleeve gastrectomy (LSG) in reducing gastroesophageal reflux disease (GERD) symptoms is still unclear. The aim of this study is to assess the effect of concomitant HHR on postoperative GERD symptoms in our patient population. MATERIALS AND METHODS: A retrospective review of patients who underwent LSG with or without HHR between 2011and 2014 was performed. Pre- and postoperative GERD symptoms were assessed at different time intervals until a maximum of 2 years after the surgery...
April 28, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28455799/periarterial-papaverine-to-treat-renal-artery-vasospasm-during-robot-assisted-laparoscopic-partial-nephrectomy
#5
Igor Sorokin, Sharnae L Stevens, Jeffrey A Cadeddu
Renal artery vasospasm can be a troublesome complication during robot-assisted laparoscopic partial nephrectomy. Urologists performing this procedure, especially if utilizing selective arterial vascular microdissection, should be aware of using papaverine for both prevention and treatment of renal artery vasospasm. We present a 33-year-old male who developed severe renal artery vasospasm just with hilar dissection causing the kidney to become ischemic. Papaverine was topically applied on the renal arteries resulting in vasodilation and reperfusion of the kidney...
April 28, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28455767/incorporating-pleiotropic-quantitative-trait-loci-in-dissection-of-complex-traits-seed-yield-in-rapeseed-as-an-example
#6
Ziliang Luo, Meng Wang, Yan Long, Yongju Huang, Lei Shi, Chunyu Zhang, Xiang Liu, Bruce D L Fitt, Jinxia Xiang, Annaliese S Mason, Rod J Snowdon, Peifa Liu, Jinling Meng, Jun Zou
A comprehensive linkage atlas for seed yield in rapeseed. Most agronomic traits of interest for crop improvement (including seed yield) are highly complex quantitative traits controlled by numerous genetic loci, which brings challenges for comprehensively capturing associated markers/genes. We propose that multiple trait interactions underlie complex traits such as seed yield, and that considering these component traits and their interactions can dissect individual quantitative trait loci (QTL) effects more effectively and improve yield predictions...
April 28, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28455701/chronic-rem-sleep-restriction-in-juvenile-male-rats-induces-anxiety-like-behavior-and-alters-monoamine-systems-in-the-amygdala-and-hippocampus
#7
Janaína da Silva Rocha-Lopes, Ricardo Borges Machado, Deborah Suchecki
Adolescence is marked by major physiological changes, including those in the sleep-wake cycle, such as phase delay, which may result in reduced sleep hours. Sleep restriction and/or deprivation in adult rats activate stress response and seem to be a risk factor for triggering emotional disorders. In the present study, we sought to evaluate the behavioral and neurobiological consequences of prolonged REM sleep restriction in juvenile male rats. Immediately after weaning, on postnatal day 21, three males from each litter were submitted to REM sleep deprivation and the other three animals were maintained in their home-cages...
April 28, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28455621/characteristics-of-advanced-gastric-cancer-with-negative-or-only-perigastric-lymph-node-metastasis-in-elderly-patients
#8
Hajime Fujishima, Yoshitake Ueda, Norio Shiraishi, Takao Hara, Michihiro Ichimanda, Yuki Shitomi, Hidefumi Shiroshita, Tsuyoshi Etoh, Masafumi Inomata
OBJECTIVES: After gastrectomy with extended lymph node (LN) dissection, the damage of celiac plexus seems to cause of disorder of eating habits. To clarify the indication of gastrectomy with limited LN dissection for elderly patients, the pathological characteristics of advanced gastric cancer in elderly patients were examined in this study. METHODS: Forty-seven patients aged ≥80 years with advanced gastric cancer (deeper than pT2) who underwent curative gastrectomy from 1998 to 2015 were enrolled...
April 28, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28455451/long-term-mir-29b-suppression-reduces-aneurysm-formation-in-a-marfan-mouse-model
#9
Homare Okamura, Fabian Emrich, Jeffrey Trojan, Peter Chiu, Alex R Dalal, Mamoru Arakawa, Tetsuya Sato, Kiril Penov, Tiffany Koyano, Albert Pedroza, Andrew J Connolly, Marlene Rabinovitch, Cristina Alvira, Michael P Fischbein
Aortic root aneurysm formation and subsequent dissection and/or rupture remain the leading cause of death in patients with Marfan syndrome. Our laboratory has reported that miR-29b participates in aortic root/ascending aorta extracellular matrix remodeling during early aneurysm formation in Fbn1(C1039G/+) Marfan mice. Herein, we sought to determine whether miR-29b suppression can reduce aneurysm formation long-term. Fbn1(C1039G/+) Marfan mice were treated with retro-orbital LNA-anti-miR-29b inhibitor or scrambled-control-miR before aneurysms develop either (1) a single dose prenatally (pregnant Fbn1(C1039G/+) mice at 14...
April 2017: Physiological Reports
https://www.readbyqxmd.com/read/28455422/impact-of-rna-structure-on-zfp36l2-interaction-with-luteinizing-hormone-receptor-mrna
#10
Christopher B Ball, Amanda C Solem, Rita M Meganck, Alain Laederach, Silvia Bv Ramos
ZFP36L2 protein destabilizes AU-rich element-containing transcripts and has been implicated in female fertility. We have shown that only one of three putative AREs within the 3' UTR of murine LHR mRNA, i.e., ARE 2197, is capable of interacting with ZFP36L2. To dissect the structural elements of ARE 2197 that mediate protein-RNA binding, we performed whole-transcript SHAPE-MaP (Selective 2' Hydroxyl Acylation by Primer Extension-Mutational Profiling). The non-functional ARE 2301 contains nucleotides that are strongly base paired, thus do not interact with ZFP36L2...
April 28, 2017: RNA
https://www.readbyqxmd.com/read/28454926/predictive-factors-for-nonsentinel-lymph-node-metastasis-in-patients-with-positive-sentinel-lymph-nodes-after-neoadjuvant-chemotherapy-nomogram-for-predicting-nonsentinel-lymph-node-metastasis
#11
Jai Min Ryu, Se Kyung Lee, Ji Young Kim, Jonghan Yu, Seok Won Kim, Jeong Eon Lee, Se Hwan Han, Yong Sik Jung, Seok Jin Nam
INTRODUCTION: Axillary lymph node (ALN) status is an important prognostic factor for breast cancer patients. With increasing numbers of patients undergoing neoadjuvant chemotherapy (NAC), issues concerning sentinel lymph node biopsy (SLNB) after NAC have emerged. PATIENTS AND METHODS: We analyzed the clinicopathologic features and developed a nomogram to predict the possibility of nonsentinel lymph node (NSLN) metastases in patients with positive SLNs after NAC...
April 6, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28454667/optimal-extent-of-prophylactic-central-neck-dissection-for-papillary-thyroid-carcinoma-comparison-of-unilateral-versus-bilateral-central-neck-dissection
#12
Han Seok Yoo, Myung Chul Shin, Yong Bae Ji, Chang Myeon Song, Seung Hwan Lee, Kyung Tae
OBJECTIVE: The aim of the study was to determine the optimal extent of prophylactic central neck dissection (pCND) in papillary thyroid carcinoma (PTC). MATERIALS AND METHODS: We studied 384 patients with clinically node-negative unilateral PTC who had undergone total thyroidectomy with pCND. Of these, 169 patients underwent unilateral pCND, and 215, bilateral pCND. RESULTS: Age, sex, and TNM stage did not differ between the two groups. The rates of occult central lymph node metastasis were 34...
April 25, 2017: Asian Journal of Surgery
https://www.readbyqxmd.com/read/28454257/sarcomatoid-urothelial-carcinoma-with-chondrosarcomatous-differentiation-of-the-ureter-a-case-report-and-review-of-the-literature
#13
Wei Lu, Yanjun Wang, Yonghong Li, Yun Cao, Hui Han, Fangjian Zhou
Sarcomatoid urothelial carcinoma of the urinary tract is associated with poor prognosis. The majority of sarcomatoid urothelial carcinomas are found in the urinary bladder, while a small minority have been shown to arise from the ureter. In the present case, a 72-year-old male patient was diagnosed with sarcomatoid urothelial carcinoma with chondrosarcomatous differentiation of the left ureter, and subsequently underwent nephroureterectomy and retroperitoneal lymph node dissection. Two lymph nodes from the renal hilum and one paraaortic lymph node were also found to have metastatic involvement; however, the patient refused to receive chemotherapy or radiotherapy and succumbed to bone and omentum metastasis at 6 months after the initial diagnosis...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28453950/histological-assessment-of-the-carotid-sheath-in-patients-with-oral-squamous-cell-carcinoma
#14
Manjari Palliyalil, Venkatesh Anehosur, Abhijit Joshi, Swetha Acharya
PURPOSE: During surgical management of the neck using various types of neck dissection, the carotid sheath is removed, in particular, the part adjacent to the jugular lymph node chain, with the intention of preventing recurrence from the lymphatics present in it. The role of the carotid sheath as a potential origin for nodal recurrence has not been proved thus far. Working in a tissue plane between the carotid sheath and the neurovascular structures of the neck can lead to a greater chance of damage to these structures...
April 4, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28453813/identification-and-allelic-dissection-uncover-roles-of-lncrnas-in-secondary-growth-of-populus-tomentosa
#15
Daling Zhou, Qingzhang Du, Jinhui Chen, Qingshi Wang, Deqiang Zhang
Long non-coding RNAs (lncRNAs) function in various biological processes. However, their roles in secondary growth of plants remain poorly understood. Here, 15,691 lncRNAs were identified from vascular cambium, developing xylem, and mature xylem of Populus tomentosa with high and low biomass using RNA-seq, including 1,994 lncRNAs that were differentially expressed (DE) among the six libraries. 3,569 cis-regulated and 3,297 trans-regulated protein-coding genes were predicted as potential target genes (PTGs) of the DE lncRNAs to participate in biological regulation...
April 26, 2017: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/28453793/impact-of-gender-on-long-term-outcomes-after-surgical-repair-for-acute-stanford-a-aortic-dissection-a-propensity-score-matched-analysis%C3%A2
#16
Anton Sabashnikov, Stephanie Heinen, Antje Christin Deppe, Mohamed Zeriouh, Alexander Weymann, Ingo Slottosch, Kaveh Eghbalzadeh, Aron-Frederik Popov, Oliver Liakopoulos, Parwis B Rahmanian, Navid Madershahian, Axel Kroener, Yeong-Hoon Choi, Ferdinand Kuhn-Régnier, André R Simon, Thorsten Wahlers, Jens Wippermann
OBJECTIVES: Previous research suggests that female gender is associated with increased mortality rates after surgery for Stanford A acute aortic dissection (AAD). However, women with AAD usually present with different clinical symptoms that may bias outcomes. Moreover, there is a lack of long-term results regarding overall mortality and freedom from major cerebrovascular events. We analysed the impact of gender on long-term outcomes after surgery for Stanford A AAD by comparing genders with similar risk profiles using propensity score matching...
May 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28453708/towards-a-global-cancer-knowledge-network-dissecting-the-current-international-cancer-genomic-sequencing-landscape
#17
D J Vis, J Lewin, R G Liao, M Mao, F Andre, R L Ward, F Calvo, B T Teh, A A Camargo, B M Knoppers, C L Sawyers, L F A Wessels, M Lawler, L L Siu, E Voest
Background: While next generation sequencing has enhanced our understanding of the biological basis of malignancy, current knowledge on global practices for sequencing cancer samples is limited. To address this deficiency, we developed a survey to provide a snapshot of current sequencing activities globally, identify barriers to data sharing and use this information to develop sustainable solutions for the cancer research community. Methods: A multi-item survey was conducted assessing demographics, clinical data collection, genomic platforms, privacy/ethics concerns, funding sources and data sharing barriers for sequencing initiatives globally...
May 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28453382/flow-cytometric-single-cell-analysis-reveals-heterogeneity-between-adipose-depots
#18
Badwi B Boumelhem, Stephen J Assinder, Kim S Bell-Anderson, Stuart T Fraser
Understanding adipose tissue heterogeneity is hindered by the paucity of methods to analyze mature adipocytes at the single cell level. Here, we report a system for analyzing live adipocytes from different adipose depots in the adult mouse. Single cell suspensions of buoyant adipocytes were separated from the stromal vascular fraction and analyzed by flow cytometry. Compared to other lipophilic dyes, Nile Red uptake effectively distinguished adipocyte populations. Nile Red fluorescence increased with adipocyte size and granularity and could be combined with MitoTracker® Deep Red or fluorescent antibody labeling to further dissect adipose populations...
April 14, 2017: Adipocyte
https://www.readbyqxmd.com/read/28452820/left-main-coronary-artery-dissection-during-aortic-valve-replacement
#19
Kenta Nakao, Toshiyuki Sawai, Junko Nakahira, Ayako Hamakawa, Hisanari Ishii, Toshiaki Minami
No abstract text is available yet for this article.
April 27, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28452616/an-ovine-model-of-cerebral-catheter-venography-for-implantation-of-an-endovascular-neural-interface
#20
Thomas James Oxley, Nicholas Lachlan Opie, Gil Simon Rind, Kishan Liyanage, Sam Emmanuel John, Stephen Ronayne, Alan James McDonald, Anthony Dornom, Timothy John Haynes Lovell, Peter John Mitchell, Iwan Bennett, Sebastien Bauquier, Leon Norris Warne, Chris Steward, David Bruce Grayden, Patricia Desmond, Stephen M Davis, Terence John O'Brien, Clive N May
OBJECTIVE Neural interface technology may enable the development of novel therapies to treat neurological conditions, including motor prostheses for spinal cord injury. Intracranial neural interfaces currently require a craniotomy to achieve implantation and may result in chronic tissue inflammation. Novel approaches are required that achieve less invasive implantation methods while maintaining high spatial resolution. An endovascular stent electrode array avoids direct brain trauma and is able to record electrocorticography in local cortical tissue from within the venous vasculature...
April 28, 2017: Journal of Neurosurgery
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