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https://www.readbyqxmd.com/read/29457432/-micro-ct-evaluating-inhibitory-effect-of-zoledronic-acid-on-polyethylene-particle-induced-periprosthetic-osteolysis-model
#1
Lian-Guo Wu, Feng-Qing Wu, Hua Chen
OBJECTIVE: To observe inhibitory effect of zoledronic acid on polyethylene particle-induced periprosthetic osteolysis model. METHODS: Thirty male adult specific-pathogen-free SD rats (weighted 250 to 300 g) were randomly divided into sham group, model group, and zoledronic acid group, 10 in each group. Modeling were building by titanium screws and polyethylene particles implanted into right femur of rats, sham group and model group were performed hypodermic injection by 0...
December 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29455094/emodin-attenuates-titanium-particle-induced-osteolysis-and-rankl-mediated-osteoclastogenesis-through-the-suppression-of-ikk-phosphorylation
#2
Juehong Li, Yamin Li, Xiaochun Peng, Bin Li, Xiangwei Yuan, Yunsu Chen
Aseptic loosening due to wear particles is a serious challenge for orthopedic surgeons, sabotaging the long-term success of total joint arthroplasty. The existing treatments for aseptic loosening are still far from satisfactory, necessitating more aggressive drug exploration. Here, we examined the effect of emodin on titanium particle-induced osteolysis and further investigated its underlying mechanism in vivo and in vitro. Thirty-two C57BL/6 mice were randomly assigned into four groups: the Sham group (sham operation with vehicle injection), Vehicle group (titanium particle treatment with vehicle injections), Low group (titanium particle treatment with injections of 10 mg/kg/day emodin) and High group (titanium particle treatment with injections of 50 mg/kg/day emodin)...
February 15, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29454028/fabricating-3d-printed-orally-disintegrating-printlets-using-selective-laser-sintering
#3
Fabrizio Fina, Christine M Madla, Alvaro Goyanes, Jiaxin Zhang, Simon Gaisford, Abdul W Basit
Selective laser sintering (SLS) is a three-dimensional printing (3DP) technology employed to manufacture plastic, metallic or ceramic objects. The aim of this study was to demonstrate the feasibility of SLS to fabricating novel solid dosage forms with accelerated drug release properties, and with a view to create orally disintegrating formulations. Two polymers (hydroxypropyl methylcellulose (HPMC E5) and vinylpyrrolidone-vinyl acetate copolymer (Kollidon ® VA 64)) were separately mixed with 5% paracetamol (used as a model drug) and 3% Candurin ® gold sheen colorant; the powder mixes were subjected to SLS printing resulting in the manufacture of printlets (3DP tablets)...
February 14, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29451298/micro-computed-tomography-visualization-of-the-vestigial-alimentary-canal-in-adult-oestrid-flies
#4
D Martín-Vega, A Garbout, F Ahmed, L M Ferrer, J Lucientes, D D Colwell, M J R Hall
Oestrid flies (Diptera: Oestridae) do not feed during the adult stage as they acquire all necessary nutrients during the parasitic larval stage. The adult mouthparts and digestive tract are therefore frequently vestigial; however, morphological data on the alimentary canal in adult oestrid flies are scarce and a proper visualization of this organ system within the adult body is lacking. The present work visualizes the morphology of the alimentary canal in adults of two oestrid species, Oestrus ovis L. and Hypoderma lineatum (de Villiers), with the use of non-invasive micro-computed tomography (micro-CT) and compares it with the highly developed alimentary canal of the blow fly Calliphora vicina Robineau-Desvoidy (Diptera: Calliphoridae)...
February 16, 2018: Medical and Veterinary Entomology
https://www.readbyqxmd.com/read/29449035/usage-of-density-analysis-based-on-micro-ct-for-studying-lung-injury-associated-with-burn-blast-combined-injury
#5
Yang Chang, Dong-Hai Zhang, Quan Hu, Ling-Ying Liu, Yong-Hui Yu, Jia-Ke Chai
BACKGROUND: Burn-blast combined injury is a kind of injury caused by heat and blast at the same time. The lung injury after burn-blast combined injuries is of primary importance, and investigation of lung injury is needed in the clinical care of patients. Computed tomography (CT) is one of the standard tools used to observe the anatomical basis and pathophysiology of acute lung injury. METHODS: We applied a method of fast 3D (three-dimensional) reconstruction to calculate the density value of the lung injury by CT analysis...
February 12, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29446238/bacterial-microleakage-at-the-abutment-implant-interface-in-vitro-study
#6
Carlos Larrucea, Aparicio Conrado, Denise Olivares, Carlos Padilla, Andrea Barrera, Olga Lobos
INTRODUCTION: In implant rehabilitation, a microspace is created at the abutment-implant interface (AII). Previous research has shown that oral microbiome can proliferate in this microspace and affect periimplant tissues, causing inflammation in peri-implant tissues. Preventing microbial leakages through the AII is therefore an important goal in implantology. OBJECTIVE: To determine the presence of marginal bacterial microleakage at the AII according to the torque applied to the prosthetic implant in vitro...
February 15, 2018: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/29446086/subchondral-bone-morphology-in-the-metacarpus-of-racehorses-in-training-changes-with-distance-from-the-articular-surface-but-not-with-age
#7
Sandra Martig, Peta L Hitchens, Mark A Stevenson, R Chris Whitton
The repetitive large loads generated during high-speed training and racing commonly cause subchondral bone injuries in the metacarpal condyles of racehorses. Adaptive bone modelling leads to focal sclerosis at the site of highest loading in the palmar aspect of the metacarpal condyles. Information on whether and how adaptive modelling of subchondral bone changes during the career of a racehorse is sparse. The aim of this cross-sectional study was to describe the changes in subchondral bone micromorphology in the area of highest loading in the palmar aspect of the metacarpal condyle in thoroughbred racehorses as a function of age and training...
February 15, 2018: Journal of Anatomy
https://www.readbyqxmd.com/read/29445961/application-of-combined-porous-tantalum-scaffolds-loaded-with-bone-morphogenetic-protein-7-to-repair-of-osteochondral-defect-in-rabbits
#8
Qian Wang, Hui Zhang, Hongquan Gan, Hui Wang, Qijia Li, Zhiqiang Wang
PURPOSE: Porous tantalum (PT) has been widely used in orthopaedic applications for low modulus of elasticity, excellent biocompatibility, and the microstructures similar to cancellous bone. In order to improve the biological activity of PT, biologically active factors can be combined with the material. The purpose of this study was to investigate if bone morphogenetic protein 7 (BMP-7) modifications could enhance the repairing of cartilage of PT in osteochondral defect in medial femoral condyle of rabbits...
February 14, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29444161/a-3d-anatomical-atlas-of-appendage-musculature-in-the-chelicerate-arthropod-limulus-polyphemus
#9
Russell D C Bicknell, Ada J Klinkhamer, Richard J Flavel, Stephen Wroe, John R Paterson
Limulus polyphemus, an archetypal chelicerate taxon, has interested both biological and paleontological researchers due to its unique suite of anatomical features and as a useful modern analogue for fossil arthropod groups. To assist the study and documentation of this iconic taxon, we present a 3D atlas on the appendage musculature, with specific focus on the muscles of the cephalothoracic appendages. As L. polyphemus appendage musculature has been the focus of extensive study, depicting the muscles in 3D will facilitate a more complete understanding thereof for future researchers...
2018: PloS One
https://www.readbyqxmd.com/read/29438616/polymer-assembly-encapsulation-of-lanthanide-nanoparticles-as-contrast-agents-for-in-vivo-micro-ct
#10
Charmainne Cruje, Joy Dunmore-Buyze, Jarret P MacDonald, David W Holdsworth, Maria Drangova, Elizabeth R Gillies
Despite recent technological advancements in microcomputed tomography (micro-CT) and contrast agent development, pre-clinical contrast agents are still predominantly iodine-based. Higher contrast can be achieved when using elements with higher atomic numbers, such as lanthanides; lanthanides also have x-ray attenuation properties that are ideal for spectral CT. However, the formulation of lanthanide-based contrast agents at the high concentrations required for vascular imaging presents a significant challenge...
February 13, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29438203/does-periosteal-graft-combined-with-platelet-rich-plasma-enhance-the-healing-of-bone-defect
#11
Arzu Türkseven, Derya Özçelik, Mert Çaliş, Hakan Hamdi Celik, Fahri Yilmaz, Ömer Önbaş, Alper Vatansever, Gaye Toplu
INTRODUCTION: This study investigated the effect of periosteal graft + platelet-rich plasma (PRP) combination on facial bone defect healing. METHODS: Five-millimeter critical sized defects in zygomatic arches of 12 adult New Zealand rabbits were created. Rabbits were randomly divided into 3 groups: First group (control group): bone defects of left zygomatic arches of 6 rabbits were wrapped with a silicone tube. Second group (periosteal graft group): bone defects of left zygomatic arches of 6 rabbits were wrapped with periosteal graft...
February 12, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29436921/volumetric-and-linear-measurements-of-lung-tumor-burden-from-non-gated-micro-ct-imaging-correlate-with-histological-analysis-in-a-genetically-engineered-mouse-model-of-non-small-cell-lung-cancer
#12
Aitor Gallastegui, James Cheung, Teresa Southard, Kelly R Hume
In vivo micro-computed tomography (CT) imaging allows longitudinal studies of pulmonary neoplasms in genetically engineered mouse models. Respiratory gating increases the accuracy of lung tumor measurements but lengthens anesthesia time in animals that may be at increased risk for complications. We hypothesized that semiautomated, volumetric, and linear tumor measurements performed in micro-CT images from non-gated scans would have correlation with histological findings. Primary lung tumors were induced in eight FVB mice with two transgenes (FVB/N-Tg(tetO-Kras2)12Hev/J; FVB...
January 1, 2018: Laboratory Animals
https://www.readbyqxmd.com/read/29435662/novel-evaluation-method-of-dentin-repair-by-direct-pulp-capping-using-high-resolution-micro-computed-tomography
#13
Motoki Okamoto, Yusuke Takahashi, Shungo Komichi, Manahil Ali, Naomichi Yoneda, Takuya Ishimoto, Takayoshi Nakano, Mikako Hayashi
OBJECTIVES: We evaluated a novel micro-computed tomography (micro-CT) assessment for quality and quantity of dentin repair, which is difficult to visualize by histological analysis, after direct pulp capping under standardized cavity preparation. MATERIALS AND METHODS: Standardized cavities were prepared on Wistar rats and direct pulp capping was performed using two commercial bioceramics, ProRoot MTA, and iRoot BP Plus. After 2 or 4 weeks, quality and quantity of tertiary dentin formation were evaluated using high-resolution micro-CT analyses including dentin mineral density, dentin mineral contents, compactness and integrity of tertiary dentin, and dentin volume with/without void space...
February 12, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29434189/ablation-of-protein-phosphatase-5-pp5-leads-to-enhanced-both-bone-and-cartilage-development-in-mice
#14
Jun Wang, Yong Cao, Bin Qiu, Jianyong Du, Tingting Wang, Chao Wang, Ran Deng, Xudong Shi, Kai Gao, Zhongwen Xie, Weidong Yong
This study aimed to investigate the role of protein phosphatase 5 (PP5) on bone and cartilage development using both in vivo and in vitro approaches. Six- to 8-week- old male PP5 knockout mice (KO) and their wild-type (WT) littermate controls were randomly selected for this study, and their body weights and bone (femur) lengths were measured. Micro-computed tomography scanning (Micro-CT) was performed to determine femoral bone density and micro-architecture. Mesenchymal stem cells (MSCs) isolated from bone marrow were used to examine the effects of PP5 on osteogenesis in vitro...
February 12, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29433006/strains-in-trussed-spine-interbody-fusion-implants-are-modulated-by-load-and-design
#15
Jason P Caffrey, Eloy Alonso, Koichi Masuda, Jessee P Hunt, Cameron N Carmody, Timothy M Ganey, Robert L Sah
Titanium cages with 3-D printed trussed open-space architectures may provide an opportunity to deliver targeted mechanical behavior in spine interbody fusion devices. The ability to control mechanical strain, at levels known to stimulate an osteogenic response, to the fusion site could lead to development of optimized therapeutic implants that improve clinical outcomes. In this study, cages of varying design (1.00 mm or 0.75 mm diameter struts) were mechanically characterized and compared for multiple compressive load magnitudes in order to determine what impact certain design variables had on localized strain...
February 3, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29432650/effects-of-ultrasonic-removal-of-fractured-files-from-the-middle-third-of-root-canals-on-dentinal-cracks-a-micro-computed-tomography-study
#16
M Fu, X Huang, W He, B Hou
AIM: To evaluate the frequency of dentinal microcracks after ultrasonic removal of fractured files from the middle third of root canals using micro-computed tomography (micro-CT). METHODOLOGY: Eighteen bilaterally matched pairs of human mandibular incisors extracted for periodontal reasons were included. The matched pairs of teeth were then divided into a control group and an experimental group, with one member of each pair assigned to each group. In the control group, the canals were instrumented using the ProTaper Next (PTN) system...
February 12, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29429057/evaluation-of-four-instruments-with-different-working-motion-using-artificial-plastic-model-with-c-shaped-single-canal
#17
Miki Sekiya, Munehiro Maeda, Ichiroh Katsuumi, Masaru Igarashi
The purpose of this study was to evaluate four instruments with different working motion for preparation of a C-shaped single canal wall using the same artificial plastic models reproduced from a human tooth. One tooth with root canal morphology C1 (the shape is an uninterrupted "C" with no separation or division) was selected among three-dimensional micro-computed tomography (micro-CT) imaging data of extracted human teeth. Imaging data were then converted into STL form data, and twenty-four C-shaped root canal model blocks were manufactured using this STL form data...
February 10, 2018: Odontology
https://www.readbyqxmd.com/read/29424622/alveolar-bone-remodeling-after-tooth-extraction-in-irradiated-mandible-an-experimental-study-with-canine-model
#18
Venni Heinonen, Timo J Ruotsalainen, Lauri Paavola, Jopi J Mikkonen, Pekka Asikainen, Arto P Koistinen, Arja M Kullaa
OBJECTIVES: The aim of the present study is to investigate the morphological and cellular changes in dental extraction socket that has been irradiated after the tooth extraction and to describe morphological characteristics of the osteocytes and osteocyte-lacunar-canalicular network (LCN) by scanning electron microscopy (SEM). MATERIAL AND METHODS: Five beagle dogs aged 1-2 years were used in this study. One side of each mandible was irradiated in two sessions and the other side of mandible (non-irradiated) served as a control...
February 9, 2018: Ultrastructural Pathology
https://www.readbyqxmd.com/read/29424129/micro-perfusion-and-quantitative-analysis-of-the-femoral-head-intraosseous-artery
#19
Xing Qiu, Liang-Liang Cheng, Ben-Jie Wang, Bao-Yi Liu, Lei Yang, Mingyang Yu, Guishan Gu, De-Wei Zhao
The present study investigates the feasibility of micro perfusion of femoral head specimens from femoral neck fracture patients by the inferior retinacular arteries and performing intraosseous artery quantitative analysis of the femoral head. Twelve femoral neck fracture patients who had undergone conventional hip replacement surgery were included in this study. Femoral head specimen arteries were first dissected and exposed and then perfused by the inferior retinacular arteries and all the femoral heads underwent micro-CT scanning...
February 9, 2018: Orthopaedic Surgery
https://www.readbyqxmd.com/read/29422992/pyrroloquinoline-quinone-plays-an-important-role-in-rescuing-bmi-1-mice-induced-developmental-disorders-of-teeth-and-mandible-anti-oxidant-effect-of-pyrroloquinoline-quinone
#20
Yuanqing Huang, Ning Chen, Dengshun Miao
To investigate whether pyrroloquinoline quinine (PQQ) plays an important role in rescuing Bmi-1-/- mice induced developmental disorders of teeth and mandible by regulating oxidative stress. We fed Bmi-1-/- mice a diet supplemented with PQQ (BKO+PQQ), BKO mice with normal diet (BKO) and wild type mice with normal diet (WT) as controls. We compared the differences of dental, mandibular phenotype by means of X-ray photography, micro CT scanning and three-dimensional reconstruction, HE staining, histochemistry, immunoistohemistry, TUNEL staining, Western blot and Flow cytometry in three groups of animals...
2018: American Journal of Translational Research
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