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https://www.readbyqxmd.com/read/28447380/lncrna-h19-modulates-wnt-%C3%AE-catenin-signaling-by-targeting-dkk4-in-hindlimb-unloaded-rat
#1
Bing Li, Jun Liu, Jie Zhao, Jian-Xiong Ma, Hao-Bo Jia, Yang Zhang, Guo-Sheng Xing, Xin-Long Ma
OBJECTIVE: To investigate the biological functions of long noncoding RNA-H19 (H19) in the pathogenesis of disuse osteoporosis (DOP). METHODS: Fifty-four male Sprague Dawley (SD) rats were randomly divided into three groups: baseline control (BC, 6), age-matched control (AC, 24), and hindlimb unloading (HLU, 24). The rats in the BC group were sacrificed at the beginning of the experiment, while the AC and HLU rats were sacrificed at different times (7, 14, 21 and 28 days after HLU)...
April 26, 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28444854/analysis-of-organic-components-in-resin-modified-pulp-capping-materials-critical-considerations
#2
Bo W Nilsen, Einar Jensen, Ulf Örtengren, Vibeke B Michelsen
The purpose of this study was to elucidate the organic composition and eluates of three resin-based pulp-capping materials in relation to their indications and safety data sheets. Uncured samples of Theracal LC, Ultra-Blend Plus, and Calcimol LC were investigated using gas chromatography-mass spectrometry (GC-MS) and ultra-performance liquid chromatography-mass spectrometry (UPLC-MS). Identification/quantification of 7-d leachables of cured samples was performed using GC-MS for 2-hydroxyethyl methacrylate (HEMA), 2-(dimethylamino)ethyl methacrylate (DMAEMA), camphorquinone (CQ), ethylene glycol dimethacrylate (EGDMA), ethyl-4-(dimethylamino)benzoate (DMABEE), and triethylene glycol dimethacrylate (TEGDMA)...
April 26, 2017: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/28441229/preliminary-model-for-the-design-of-a-custom-middle-ear-prosthesis
#3
Brandon Kamrava, Jonathan A Gerstenhaber, Mamta Amin, Yah-El Har-El, Pamela C Roehm
HYPOTHESIS: Custom prostheses could be used to recreate the ossicular chain and improve hearing. BACKGROUND: Ossicular discontinuity or fixation occurs in 55% of cases of conductive hearing loss, with most cases involving the incus. Reconstruction has been achieved by a variety of methods; however, there has been little improvement in hearing outcomes in decades. METHODS: Precise measurements of anatomic dimensions, weight, and center of gravity were taken from 19 cadaveric incudes...
April 24, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28438150/intermittent-parathyroid-hormone-improve-bone-microarchitecture-of-the-mandible-and-femoral-head-in-ovariectomized-rats
#4
Ying-Ju Chen, Shun-Ping Wang, Fu-Chou Cheng, Pei-Yu Hsu, Yu-Fen Li, Jay Wu, Heng-Li Huang, Ming-Tzu Tsai, Jui-Ting Hsu
BACKGROUND: Intermittent parathyroid hormone (PTH) can be used to treat osteoporosis of the spine and hip. However, whether it can be used to treat osteoporosis of the mandible is unclear. The purpose of this study was to explore the influence of applying intermittent PTH to ovariectomized rats on the trabecular bone microarchitecture of the mandible and femoral head. METHODS: Eighteen female rats were divided into three groups: the healthy group, ovariectomized (OVX) group, and OVX + PTH group...
April 24, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28432937/subantibiotic-dose-of-azithromycin-attenuates-alveolar-bone-destruction-and-improves-trabecular-microarchitectures-in-a-rat-model-of-experimental-periodontitis-a-study-using-micro-computed-tomography
#5
Hye-Shin Park, Yong Sun Lee, Eun-Young Choi, Jeom-Il Choi, In Soon Choi, Sung-Jo Kim
Azithromycin, a macrolide antibiotic, has anti-inflammatory and immunomodulatory activities apart from its antibacterial properties. In this study, we examined the efficacy of subantibiotic dose of azithromycin on ligature-induced periodontitis in rats using micro-computed tomography (micro-CT) imaging and bone parameter analysis. Male Sprague-Dawley rats were allocated to the following four groups: non-ligation (NL) group; ligation-only (L) group; ligation-plus-subantibiotic dose azithromycin (SA) group; and 4) ligation-plus-antibiotic dose azithromycin (AA) group...
April 19, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28431361/uncertainty-quantification-and-validation-of-3d-lattice-scaffolds-for-computer-aided-biomedical-applications
#6
Recep M Gorguluarslan, Seung-Kyum Choi, Christopher J Saldana
A methodology is proposed for uncertainty quantification and validation to accurately predict the mechanical response of lattice structures used in the design of scaffolds. Effective structural properties of the scaffolds are characterized using a developed multi-level stochastic upscaling process that propagates the quantified uncertainties at strut level to the lattice structure level. To obtain realistic simulation models for the stochastic upscaling process and minimize the experimental cost, high-resolution finite element models of individual struts were reconstructed from the micro-CT scan images of lattice structures which are fabricated by selective laser melting...
April 12, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28430299/effect-of-retreatment-instruments-on-microcrack-formation-a-microcomputed-tomography-study
#7
Mustafa M Koçak, Neslihan Y Çırakoğlu, Sibel Koçak, Baran C Sağlam, Ersan Çiçek, Sevinç A Türker, Emre Bodrumlu
INTRODUCTION: The purpose of this study was to compare the occurrence of microcracks in teeth prepared with different retreatment systems using microcomputed tomography (micro-CT). METHODS: Forty-two freshly extracted mandibular premolar teeth were used. The root canals were instrumented with stainless steel K-files to an apical size of 35/.02 using the balanced-force technique and were obturated using the passive compaction technique. The specimens were divided into 3 experimental groups according to retreatment system used (n = 14): ProTaper Universal retreatment (PTUR), Mtwo retreatment (MTR), or D-RaCe retreatment (D-RC) systems...
April 4, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28426184/alterations-in-mandibular-morphology-associated-with-glypican-1-and-glypican-3-gene-mutations
#8
M Mian, S Ranjitkar, G C Townsend, P J Anderson
OBJECTIVES: Glypican 1 (GPC1) and glypican 3 (GPC3) are bone co-regulators that act downstream in many of the signalling pathways associated with craniosynostosis. Morphometric data from GPC-knockout mice were analysed to determine whether elimination of GPC1 and GPC3 genes would alter mandibular morphology. SETTING AND SAMPLE POPULATION: The murine model included five male and five female mandibles in each of GPC1-knockout, GPC1/GPC3-knockout and wild-type (control) groups...
April 20, 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28425918/rhein-and-pdms-functionalized-c-c-composites-as-prosthetic-implants-for-bone-repair-application
#9
Zhenzhen Jia, Cui Yang, Jiajia Jiao, Xinyu Li, Dashuai Zhu, Yongchao Yang, Jingyi Yang, Yongzhe Che, Yun Lu, Xizeng Feng
A major issue in bone tissue engineering is the selection of biocompatible materials for implants, to reduce unwanted inflammatory reactions and promote cell adhesion. Bone tissues growth on suitable biomedical implants can shorten recovery and hospitalization after surgery. Therefore, a method to improve tissue-implant integration and healing would be of scientific and clinical interest. In this work, we permeated Polydimethylsiloxane (PDMS) into Carbon/carbon (C/C) composites (PDMS-C/C) and then coated it with 4, 5-dihydroxyanthraquinone-2-carboxylic acid (Rhein) to create Rhein-PDMS-C/C to increase its biocompatibility and reduce the occurrence of inflammatory reactions...
April 20, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28425622/targeted-disruption-of-nf1-in-osteocyte-increases-fgf23-and-osteoid-with-osteomalacia-like-bone-phenotype
#10
Nobuhiro Kamiya, Ryosuke Yamaguchi, Olumide Aruwajoye, Audrey Kim, Gen Kuroyanagi, Matthew Phipps, Naga Suresh Adapala, Jian Q Feng, Harry K W Kim
Neurofibromatosis type 1 (NF1, OMIM 162200), caused by NF1 gene mutations, exhibits multi-system abnormalities including skeletal deformities in humans. Osteocytes play critical roles in controlling bone modeling and remodeling. However, the role of neurofibromin, the protein product of the NF1 gene, in osteocytes is largely unknown. This study investigated the role of neurofibromin in osteocytes by disrupting Nf1 under the Dmp1-promoter. The conditional knockout (Nf1 cKO) mice displayed serum profile of a metabolic bone disorder with an osteomalacia-like bone phenotype...
April 20, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28419369/laboratory-x-ray-micro-computed-tomography-a-user-guideline-for-biological-samples
#11
Anton du Plessis, Chris Broeckhoven, Anina Guelpa, Stephan Gerhard le Roux
Laboratory X-ray micro-computed tomography (micro-CT) is a fast growing method in scientific research applications that allows for non-destructive imaging of morphological structures. This paper provides an easily operated "how-to" guide for new potential users and describes the various steps required for successful planning of research projects that involve micro-CT. Background information on micro-CT is provided, followed by relevant set-up, scanning, reconstructing and visualization methods and considerations...
April 17, 2017: GigaScience
https://www.readbyqxmd.com/read/28416309/detection-of-apical-root-cracks-using-spectral-domain-and-swept-source-optical-coherence-tomography
#12
Bruna Paloma de Oliveira, Andréa Cruz Câmara, Daniel Amancio Duarte, Anderson Stevens Leonidas Gomes, Richard John Heck, Antonio Celso Dantas Antonino, Carlos Menezes Aguiar
INTRODUCTION: This study aimed to evaluate the ability of 2 optical coherence tomographic (OCT) systems to detect apical dentinal microcracks. METHODS: Twenty extracted human single-rooted mandibular incisors were selected. After root canal preparation with an R40 Reciproc file (VDW, Munich, Germany), the specimens presenting apical microcracks were identified using micro-computed tomographic (micro-CT) scanning as the gold standard. Then, the apical portions of the roots were imaged with spectral domain OCT (SD-OCT) and swept-source OCT systems, and the resulting images were blindly evaluated by 3 independent examiners to detect microcracks...
April 14, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28415391/biological-activity-evaluation-of-magnesium-fluoride-coated-mg-zn-zr-alloy-in-vivo
#13
Hongfeng Jiang, Jingbo Wang, Minfang Chen, Debao Liu
AIM: To explore the biodegradable characteristics and biological properties, which could promote new bone formation, of MgF2 coated magnesium alloy (Mg-3wt%Zn-0.5wt%Zr) in rabbits. METHODS: Magnesium alloy with MgF2 coating was made and the MgF2/Mg-Zn-Zr was implanted in the femoral condyle of rabbits. Twelve healthy adult Japanese white rabbits in weight of 2.8-3.2kg were averagely divided into A(Mg-Zn-Zr) group and B(MgF2/MgZn-Zr) group. Indexes such as microstructural evolution, SEM scan, X-ray, Micro-CT and mechanical properties were observed and detected at 1th day, 2th, 4th, 8th, 12th, 24th week after implantation...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28414206/wenshen-zhuanggu-formula-effectively-suppresses-breast-cancer-bone-metastases-in-a-mouse-xenograft-model
#14
Jia-Jia Li, Wei-Ling Chen, Jian-Yi Wang, Qian-Wen Hu, Zhen-Ping Sun, Shuai Zhang, Sheng Liu, Xiang-Hui Han
Wenshen Zhuanggu formula (WSZG) is a traditional Chinese medicine used as an adjuvant for the prevention of bone metastases in breast cancer patients. In this study we investigated the efficacy of WSZG in preventing bone metastases and the potential mechanisms in a mouse xenograft model of breast cancer bone metastases. This model was established by injection of human MDA-MB-231BO-Luc breast cancer cells alone or a mixture of the cancer cells with bone marrow-derived mesenchymal stem cells (BMSCs) into left ventricle of the heart in female nude mice...
April 17, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28412218/evaluation-of-the-combined-use-of-metronomic-zoledronic-acid-and-coriolus-versicolor-in-intratibial-breast-cancer-mouse-model
#15
Chun-Hay Ko, Grace Gar-Lee Yue, Si Gao, Ke-Wang Luo, Wing-Sum Siu, Wai-Ting Shum, Hoi-Ting Shiu, Julia Kin-Ming Lee, Gang Li, Ping-Chung Leung, Andreas Evdokiou, Clara Bik-San Lau
ETHNOPHARMACOLOGICAL RELEVANCE: Coriolus versicolor (CV) is a mushroom traditionally used for strengthening the immune system and nowadays used as immunomodulatory adjuvant in anticancer therapy. Breast cancer usually metastasizes to the skeleton, interrupts the normal bone remodeling process and causes osteolytic bone lesions. The aims of the present study were to evaluate its herb-drug interaction with metronomic zoledronate in preventing cancer propagation, metastasis and bone destruction...
April 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28409326/effect-of-corticision-on-orthodontic-tooth-movement-in-a-rat-model-as-assessed-by-rna-sequencing
#16
Qihui Gu, Shuyu Guo, Dongyue Wang, Tingting Zhou, Lin Wang, Zhendong Wang, Junqing Ma
Corticision is a common technique to accelerate orthodontic tooth movement; however, not much is known about the underlying mechanisms. In this study, we investigated the mechanism of alveolar tissue remodeling after corticision in a rat model of tooth movement (TM) by analyzing the differential transcriptome. A total of 36 male rats were equally divided into TM and TM with corticision (TM+C) groups. Alveolar bone response was examined using micro-computed tomography (micro-CT). Osteoclasts and osteoblasts were quantified on tartrate-resistant acid phosphatase (TRAP) and Goldner's trichrome staining...
April 13, 2017: Journal of Molecular Histology
https://www.readbyqxmd.com/read/28405581/angiogenesis-in-newly-regenerated-bone-by-secretomes-of-human-mesenchymal-stem-cells
#17
Wataru Katagiri, Takamasa Kawai, Masashi Osugi, Yukiko Sugimura-Wakayama, Kohei Sakaguchi, Taku Kojima, Tadaharu Kobayashi
BACKGROUND: For an effective bone graft for reconstruction of the maxillofacial region, an adequate vascular network will be required to supply blood, osteoprogenitor cells, and growth factors. We previously reported that the secretomes of bone marrow-derived mesenchymal stem cells (MSC-CM) contain numerous growth factors such as insulin-like growth factor (IGF)-1, transforming growth factor (TGF)-β1, and vascular endothelial growth factor (VEGF), which can affect the cellular characteristics and behavior of regenerating bone cells...
December 2017: Maxillofacial Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28403331/effects-of-avocado-soybean-unsaponifiables-asu-on-the-treatment-of-ligature-induced-periodontitis-in-rats
#18
Guilherme José Pimentel Lopes de Oliveira, Luiz Guilherme Freitas de Paula, João Antônio Chaves de Souza, Rubens Spin-Neto, Andreas Stavropoulos, Rosemary Adriana Chiérici Marcantonio
The purpose of this study is to evaluate the effect of the avocado/soybean unsaponifiables (ASU) on the treatment of induced periodontitis in rats. Periodontitis was induced in 84 rats via ligature placement around the second upper molar, which was removed after 7 days, and scaling and root planning (SRP) was performed at this time. Subsequently, the rats were randomly allocated to four groups with 21 animals each: One SRP group in which saline solution was administered (SS), and three groups in which ASU was administered (0...
April 10, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28402679/inhibition-of-osteogenesis-surrounding-the-titanium-implant-by-cgrp-deficiency
#19
Yao Liu, Guangsen Zheng, Li Liu, Zhi Wang, Yiyao Wang, Qianming Chen, En Luo
Previous studies have suggested one of neurotransmitters, calcitonin gene-related peptide (CGRP), modulates local regulation of bone metabolism; however, the regulating signaling pathway is still being explored. The objective of this study was to determine whether CGRP deficiency affects the osteogenesis surrounding titanium implants in vivo. Titanium screws were implanted in 72 adult rats, which were divided into three groups randomly: Sham, inferior alveolar neurectomy (IAN), and IAN+CGRP. Saline solution containing CGRP (concentration: 100 nmol/L) was injected into the area surrounding the implants in the IAN+CGRP group every day post operation...
April 12, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/28401929/the-effect-of-l-prf-membranes-on-bone-healing-in-rabbit-tibiae-bone-defects-micro-ct-and-biomarker-results
#20
Fernanda Faot, Sanne Deprez, Katleen Vandamme, Germana V Camargos, Nelson Pinto, Jasper Wouters, Joost van den Oord, Marc Quirynen, Joke Duyck
More insight into the biological fundamentals of leukocyte platelet-rich fibrin (L-PRF) guided healing is necessary to recommend its application, in particular in deficient bone sites that need to support implants. This study investigated the short-term bone healing effect of L-PRF treatment in cylindrical non-critical sized bone defects with 3 mm diameter and 6 mm depth in tibiae of 18 adult male New Zealand White rabbits. After a randomization process, 96 bone defects were prepared and half of them were filled with a L-PRF membrane, while untreated defects in the opposite tibia served as control group...
April 12, 2017: Scientific Reports
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