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vitamin k and atherosclerosis

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https://www.readbyqxmd.com/read/28717807/vitamin-d-status-and-prevalent-early-age-related-macular-degeneration-in-african-americans-and-caucasians-the-atherosclerosis-risk-in-communities-aric-study
#1
A E Millen, J Nie, M W Sahli, J A Mares, K J Meyers, B E K Klein, M J LaMonte, P L Lutsey, C A Andrews, R Klein
OBJECTIVES: Vitamin D status has been hypothesized to protect against development of early age-related macular degeneration (AMD) via its anti-inflammatory properties and its possible beneficial influence on blood pressure control. We investigated the association between vitamin D status and prevalent early AMD in a community-based cohort. DESIGN: This was a cross-sectional study. SETTING: This was a secondary data analysis of already existing data from the Atherosclerosis Risk in Communities Study (ARIC) cohort collected from 1990 to 1995...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28707135/secondary-stroke-prevention-in-cryptogenic-stroke-and-embolic-stroke-of-undetermined-source-esus
#2
REVIEW
Hans-Christoph Diener, Richard Bernstein, Robert Hart
PURPOSE OF THE REVIEW: The purpose of the study was to review the literature on cryptogenic stroke and embolic stroke of undetermined stroke (ESUS). Cryptogenic stroke according to TOAST criteria is a stroke which is not due to cardiogenic embolism, small vessel disease with lacunes or large vessel disease of brain supplying arteries. In the context of secondary stroke prevention studies, cryptogenic stroke is not operationally defined. RECENT FINDINGS: The new concept of "embolic stroke of undetermined source" (ESUS) provides an operational definition...
September 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28703931/rationale-and-design-of-a-randomized-trial-of-apixaban-vs-warfarin-to-evaluate-atherosclerotic-calcification-and-vulnerable-plaque-progression
#3
Kazuhiro Osawa, Rine Nakanishi, Theingi Tiffany Win, Dong Li, Sina Rahmani, Negin Nezarat, Nasim Sheidaee, Matthew J Budoff
Vitamin K antagonists (VKAs) are known to increase vascular calcification, suggesting increased cardiovascular disease events. Apixaban is an oral direct factor Xa inhibitor superior to warfarin at preventing stroke or systemic embolism and may stabilize coronary atherosclerosis. The potential benefits of avoiding VKA therapy and the favorable effects of factor Xa inhibitors could contribute to cardiovascular disease event reduction. We hypothesized that apixaban inhibits vascular calcification and coronary atherosclerosis progression compared with warfarin in patients with atrial fibrillation (AF)...
July 13, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28639365/vascular-calcification-vitamin-k-and-warfarin-therapy-possible-or-plausible-connection
#4
Aino Siltari, Heikki Vapaatalo
Atherosclerosis is a pathological process underpinning many cardiovascular diseases; it is the main cause of global mortality. Atherosclerosis is characterized by an invasion of inflammatory cells, accumulation of lipids and the formation of fatty streaks (plaques) which subsequently allow accumulation of calcium and other minerals leading to a disturbance in the vascular endothelium and its regulatory role in arterial function. Vascular calcification is a different process, stringently regulated mainly by local factors, in which osteoblast-like cells accumulate in the muscular layer of arteries ultimately taking on the physiological appearance of bone...
June 21, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28587577/vitamin-k2-can-suppress-the-expression-of-toll-like-receptor-2-tlr2-and-tlr4-and-inhibit-calcification-of-aortic-intima-in-apoe-mice-as-well-as-smooth-muscle-cells
#5
Zhaojun Wang, Zhongqun Wang, Jie Zhu, Xinguang Long, Jinchuan Yan
Background and objectives Vascular calcification is a common complication in atherosclerosis. Accumulating evidence showed that Toll-like receptors (TLRs) mediate pro-inflammatory and atherosclerosis. Recent studies demonstrated that vascular calcification is one of the detrimental effects of vitamin K (Vit K) antagonists. However, the effects of Vit K on the expression of TLR2 and 4 and intimal calcification in artery remained unidentified. Methods and results Eighteen ApoE(-/-) mice were randomly divided into model group, Vit K-treated group, and control group...
January 1, 2017: Vascular
https://www.readbyqxmd.com/read/28164642/serum-homocysteine-folate-and-vitamin-b12-levels-in-carbamazepine-treated-epileptic-children
#6
Tarun K Sharma, S K Vardey, S Sitaraman
BACKGROUND: Antiepileptic drugs (AEDs) have been associated with metabolic consequences that lead to an increase in risk of atherosclerosis in patients with epilepsy. Therefore, we evaluated whether differences exist in homocysteine, folate, and vitamin B12 levels in children receiving carbamazepine (CBZ) monotherapy. METHODS: A total of 58 newly diagnosed epileptic children with ages ranging from 2 to 15 years were enrolled at the start of study. However, after 3 months follow up, the final total sample size was only 50 epileptic children...
July 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28041602/serum-vitamin-d-and-sex-hormones-levels-in-men-and-women-the-multi-ethnic-study-of-atherosclerosis-mesa
#7
Di Zhao, Pamela Ouyang, Ian H de Boer, Pamela L Lutsey, Youssef M K Farag, Eliseo Guallar, David S Siscovick, Wendy S Post, Rita R Kalyani, Kevin L Billups, Erin D Michos
INTRODUCTION: 25-hydroxyvitamin D [25(OH)D] deficiency has been associated with low testosterone levels in men, but there are conflicting reports of its associations with sex hormones in women. Less is known about whether these associations are independent of adiposity and lifestyle factors, and whether they differ by race/ethnicity. AIM: To examine associations of 25(OH)D concentrations with sex hormone levels. METHODS: Cross-sectional analysis of 3017 men and 2929 women in a multi-ethnic cohort...
February 2017: Maturitas
https://www.readbyqxmd.com/read/28027627/association-of-vitamin-d-deficiency-with-cardiovascular-disease-risk-in-children-implications-for-the-asia-pacific-region
#8
REVIEW
Indah K Murni, Dian C Sulistyoningrum, Vicka Oktaria
BACKGROUND AND OBJECTIVES: Vitamin D deficiency significantly affects cardiovascular disease risk. Cardiovascular disease is epidemic in nature. Because the prevalence of cardiovascular disease has been increasing in children, it has been changing from an adulthood disease to a childhood disease. Therefore, formulating an effective prevention strategy against cardiovascular disease development in children is crucial. METHODS AND STUDY DESIGN: From PubMed, we identified and reviewed studies evaluating the association of vitamin D deficiency with cardiovascular disease risk in children...
December 2016: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27586865/adequate-vitamin-d-status-is-associated-with-the-reduced-odds-of-prevalent-diabetic-retinopathy-in-african-americans-and-caucasians
#9
MULTICENTER STUDY
Amy E Millen, Michelle W Sahli, Jing Nie, Michael J LaMonte, Pamela L Lutsey, Barbara E K Klein, Julie A Mares, Kirstin J Meyers, Christopher A Andrews, Ronald Klein
BACKGROUND: Vitamin D status has been hypothesized to protect against development of diabetic retinopathy via its anti-inflammatory and anti-angiogenic properties. Additionally, in vitro and in vivo studies suggest vitamin D favorably influences blood pressure and blood glucose control, strong risk factors for diabetic retinopathy. We examined the association between vitamin D status and prevalent diabetic retinopathy in participants with diabetes from a population-based cohort. METHODS: Among participants in the Atherosclerosis Risk in Communities (ARIC) study with diabetes at visit 3 (1993-1995), 1339 (906 Caucasians, 433 African Americans) had serum 25-hydroxyvitamin (25[OH]D) concentrations assessed at visit 2 (1989-1992) and nonmydriatic retinal photographs taken at visit 3...
September 1, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27529239/vitamin-c-and-heart-health-a-review-based-on-findings-from-epidemiologic-studies
#10
REVIEW
Melissa A Moser, Ock K Chun
Vitamin C is a powerful dietary antioxidant that has received considerable attention in the literature related to its possible role in heart health. Although classical vitamin C deficiency, marked by scurvy, is rare in most parts of the world, some research has shown variable heart disease risks depending on plasma vitamin C concentration, even within the normal range. Furthermore, other studies have suggested possible heart-related benefits to vitamin C taken in doses beyond the minimal amounts required to prevent classically defined deficiency...
August 12, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27508317/circulating-des-gamma-carboxy-prothrombin-is-not-associated-with-cardiovascular-calcification-or-stiffness-the-multi-ethnic-study-of-atherosclerosis-mesa
#11
John Danziger, Rebekah L Young, Kyla M Shea, Daniel A Duprez, David R Jacobs, Russell P Tracy, Joachim H Ix, Nancy S Jenny, Kenneth J Mukamal
BACKGROUND AND AIMS: Vitamin K-dependent protein (VKDP) activity may have a role in preventing cardiovascular calcification, but has not previously been studied in large, generally healthy populations. METHODS: Using an elevated ankle-brachial index (ABI) as a measure of medial vascular calcification, we performed a case-cohort analysis within the Multi-Ethnic Study of Atherosclerosis, measuring Des-gamma-carboxy prothrombin (DCP) to estimate VKDP activity. In secondary analyses of the weighted subcohort, we examined the cross-sectional associations between DCP and prevalent vascular calcification of the coronary vessels, aortic and mitral valves, and aortic wall, and with vascular stiffness...
September 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27045701/spectral-response-in-reversing-coronary-artery-atherosclerosis-with-vitamin-d-supplementation-in-postmenopausal-cynomolgus-monkeys
#12
James K Pru
No abstract text is available yet for this article.
May 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27034473/loss-of-biglycan-enhances-thrombin-generation-in-apolipoprotein-e-deficient-mice-implications-for-inflammation-and-atherosclerosis
#13
Maria Grandoch, Christina Kohlmorgen, Ariane Melchior-Becker, Kathrin Feldmann, Susanne Homann, Julia Müller, Lena-Sophia Kiene, Jinyang Zeng-Brouwers, Friederike Schmitz, Nadine Nagy, Amin Polzin, Nina S Gowert, Margitta Elvers, Philipp Skroblin, Xiaoke Yin, Manuel Mayr, Liliana Schaefer, Lisa R Tannock, Jens W Fischer
OBJECTIVE: Thrombin signaling promotes atherosclerosis by initiating inflammatory events indirectly through platelet activation and directly via protease-activated receptors. Therefore, endogenous thrombin inhibitors may be relevant modulators of atheroprogression and cardiovascular risk. In addition, endogenous thrombin inhibitors may affect the response to non-vitamin K-dependent oral anticoagulants. Here, the question was addressed whether the small leucine-rich proteoglycan biglycan acts as an endogenous thrombin inhibitor in atherosclerosis through activation of heparin cofactor II...
May 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27034472/vitamin-k-dependent-protein-activity-and-incident-ischemic-cardiovascular-disease-the-multi-ethnic-study-of-atherosclerosis
#14
MULTICENTER STUDY
John Danziger, Rebekah L Young, M Kyla Shea, Russell P Tracy, Joachim H Ix, Nancy S Jenny, Kenneth J Mukamal
OBJECTIVE: Vitamin K-dependent proteins (VKDPs), which require post-translational modification to achieve biological activity, seem to contribute to thrombus formation, vascular calcification, and vessel stiffness. Whether VKDP activity is prospectively associated with incident cardiovascular disease has not been studied. APPROACH AND RESULTS: VKDP activity was determined by measuring circulating des-γ-carboxy prothrombin concentrations in a random sample of 709 multiethnic adults free of cardiovascular disease drawn from the Multi-Ethnic Study of Atherosclerosis (MESA)...
May 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/26959054/phylloquinone-and-menaquinone-4-tissue-distribution-at-different-life-stages-in-male-and-female-sprague-dawley-rats-fed-different-vk-levels-since-weaning-or-subjected-to-a-40-calorie-restriction-since-adulthood
#15
COMPARATIVE STUDY
Guylaine Ferland, Isabelle Doucet, Dominique Mainville
Whether through the vitamin K-dependent proteins or the individual K vitamers, vitamin K (VK) is associated with a number of age-related conditions (e.g., osteoporosis, atherosclerosis, insulin resistance, cognitive decline). In light of this, we investigated the influence of lifetime dietary VK exposure on the tissue distribution of phylloquinone (K₁) and menaquinone-4 (MK-4) vitamers in 3-, 12- and 22-month-old male and female rats fed different K₁ diets since weaning or subjected to a 40% calorie restricted diet (CR) since adulthood...
March 4, 2016: Nutrients
https://www.readbyqxmd.com/read/26674156/long-term-warfarin-therapy-and-biomarkers-for-osteoporosis-and-atherosclerosis
#16
Sayaka Namba, Minako Yamaoka-Tojo, Takehiro Hashikata, Yuki Ikeda, Lisa Kitasato, Takuya Hashimoto, Takao Shimohama, Taiki Tojo, Naonobu Takahira, Takashi Masuda, Junya Ako
BACKGROUND: Stroke prevention by warfarin, a vitamin K antagonist, has been an integral part in the management of atrial fibrillation. Vitamin K-dependent matrix Gla protein (MGP) has been known as a potent inhibitor of arterial calcification and osteoporosis. Therefore, we hypothesized that warfarin therapy affects bone mineral metabolism, vascular calcification, and vascular endothelial dysfunction. METHODS: We studied 42 atrial fibrillation patients at high-risk for atherosclerosis having one or more coronary risk factors...
December 2015: BBA Clinical
https://www.readbyqxmd.com/read/26593943/new-insights-into-the-pros-and-cons-of-the-clinical-use-of-vitamin-k-antagonists-vkas-versus-direct-oral-anticoagulants-doacs
#17
REVIEW
Rick H van Gorp, Leon J Schurgers
Vitamin K-antagonists (VKA) are the most widely used anticoagulant drugs to treat patients at risk of arterial and venous thrombosis for the past 50 years. Due to unfavorable pharmacokinetics VKA have a small therapeutic window, require frequent monitoring, and are susceptible to drug and nutritional interactions. Additionally, the effect of VKA is not limited to coagulation, but affects all vitamin K-dependent proteins. As a consequence, VKA have detrimental side effects by enhancing medial and intimal calcification...
November 17, 2015: Nutrients
https://www.readbyqxmd.com/read/26573712/growth-arrest-specific-6-exacerbates-pressure-overload-induced-cardiac-hypertrophy
#18
Yi-Fan Zhao, Da-Chun Xu, Guo-Fu Zhu, Meng-Yun Zhu, Kai Tang, Wei-Ming Li, Ya-Wei Xu
Growth arrest-specific 6 (GAS6) is a member of the vitamin K-dependent protein family that is involved in the regulation of the cardiovascular system, including vascular remodeling, homeostasis, and atherosclerosis. However, there is still no study that systemically elucidates the role of GAS6 in cardiac hypertrophy. Here, we found that GAS6 was upregulated in human dilated cardiomyopathic hearts, hypertrophic murine hearts, and angiotensin II-treated cardiomyocytes. Next, we examined the influence of GAS6 expression in response to a cardiac stress by inducing chronic pressure overload with aortic banding in wild-type and GAS6-knockout mice or cardiac-specific GAS6 overexpressing mice...
January 2016: Hypertension
https://www.readbyqxmd.com/read/26516910/menaquinone-7-supplementation-to-reduce-vascular-calcification-in-patients-with-coronary-artery-disease-rationale-and-study-protocol-vitak-cac-trial
#19
RANDOMIZED CONTROLLED TRIAL
Liv M Vossen, Leon J Schurgers, Bernard J van Varik, Bas L J H Kietselaer, Cees Vermeer, Johannes G Meeder, Braim M Rahel, Yvonne J M van Cauteren, Ge A Hoffland, Roger J M W Rennenberg, Koen D Reesink, Peter W de Leeuw, Abraham A Kroon
Coronary artery calcification (CAC) develops early in the pathogenesis of atherosclerosis and is a strong and independent predictor of cardiovascular disease (CVD). Arterial calcification is caused by an imbalance in calcification regulatory mechanisms. An important inhibitor of calcification is vitamin K-dependent matrix Gla protein (MGP). Both preclinical and clinical studies have shown that inhibition of the vitamin K-cycle by vitamin K antagonists (VKA) results in elevated uncarboxylated MGP (ucMGP) and subsequently in extensive arterial calcification...
October 28, 2015: Nutrients
https://www.readbyqxmd.com/read/26512945/early-atherosclerosis-in-ulcerative-colitis-cross-sectional-case-control-study
#20
Samit S Jain, Dharmesh K Shah, Pravir A Gambhire, Ravi U Varma, Qais Q Contractor, Pravin M Rathi
OBJECTIVE: To study the extent of early atherosclerosis in ulcerative colitis (UC) patients by measuring carotid intima-media thickness (CIMT) and the correlation between CIMT, serum homocysteine level and homeostasis model assessment-insulin resistance (HOMA-IR) in UC. METHODS: We studied 60 UC patients and 60 healthy controls. Individuals with risk factors for atherosclerosis were excluded from the study. Fasting blood glucose, lipid profile, HOMA-IR, erythrocyte sedimentation rate (ESR), serum vitamin B12 and homocysteine levels were measured in all participants...
November 2015: Journal of Digestive Diseases
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