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https://www.readbyqxmd.com/read/28077444/protein-interactions-during-the-flavivirus-and-hepacivirus-life-cycle
#1
Gisa Gerold, Janina Bruening, Bettina Weigel, Thomas Pietschmann
Protein-protein interactions govern biological functions in cells, in the extracellular milieu and at the border between cells and extracellular space. Viruses are small intracellular parasites and thus rely on protein interactions to produce progeny inside host cells and to spread from cell to cell. Usage of host proteins by viruses can have severe consequences e.g. apoptosis, metabolic disequilibria or altered cell proliferation and mobility. Understanding protein interactions during virus infection can thus educate us on viral infection and pathogenesis mechanisms...
January 11, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28068627/thiosemicarbazones-and-phthalyl-thiazoles-compounds-exert-antiviral-activity-against-yellow-fever-virus-and-saint-louis-encephalitis-virus
#2
Carolina Colombelli Pacca, Rafael Elias Marques, José Wanderlan P Espindola, Gevânio B O Oliveira Filho, Ana Cristina Lima Leite, Mauro Martins Teixeira, Mauricio L Nogueira
Arboviruses, arthropod-borneviruses, are frequency associated to human outbreak and represent a serious health problem. The genus Flavivirus, such as Yellow Fever Virus (YFV) and Saint Louis Encephalitis Virus (SLEV), are important pathogens with high morbidity and mortality worldwide. In Brazil, YFV is maintained in sylvatic cycle, but many cases are notified annually, despite the efficiency of vaccine. SLEV causes an acute encephalitis and is widely distributed in the Americas. There is no specific antiviral drugs for these viruses, only supporting treatment that can alleviate symptoms and prevent complications...
January 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28027002/mathematical-modeling-based-on-ordinary-differential-equations-a-promising-approach-to-vaccinology
#3
Carla Rezende Barbosa Bonin, Guilherme Cortes Fernandes, Rodrigo Weber Dos Santos, Marcelo Lobosco
New contributions that aim to accelerate the development or to improve the efficacy and safety of vaccines arise from many different areas of research and technology. One of these areas is computational science, which traditionally participates in the initial steps, such as the pre-screening of active substances that have the potential to become a vaccine antigen. In this work, we present another promising way to use computational science in vaccinology: mathematical and computational models of important cell and protein dynamics of the immune system...
December 27, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28017559/spread-of-yellow-fever-virus-outbreak-in-angola-and-the-democratic-republic-of-the-congo-2015-16-a-modelling-study
#4
Moritz U G Kraemer, Nuno R Faria, Robert C Reiner, Nick Golding, Birgit Nikolay, Stephanie Stasse, Michael A Johansson, Henrik Salje, Ousmane Faye, G R William Wint, Matthias Niedrig, Freya M Shearer, Sarah C Hill, Robin N Thompson, Donal Bisanzio, Nuno Taveira, Heinrich H Nax, Bary S R Pradelski, Elaine O Nsoesie, Nicholas R Murphy, Isaac I Bogoch, Kamran Khan, John S Brownstein, Andrew J Tatem, Tulio de Oliveira, David L Smith, Amadou A Sall, Oliver G Pybus, Simon I Hay, Simon Cauchemez
BACKGROUND: Since late 2015, an epidemic of yellow fever has caused more than 7334 suspected cases in Angola and the Democratic Republic of the Congo, including 393 deaths. We sought to understand the spatial spread of this outbreak to optimise the use of the limited available vaccine stock. METHODS: We jointly analysed datasets describing the epidemic of yellow fever, vector suitability, human demography, and mobility in central Africa to understand and predict the spread of yellow fever virus...
December 22, 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28013052/yellow-fever-vaccination-once-in-a-lifetime
#5
EDITORIAL
Martin P Grobusch, Mariëlle van Aalst, Abraham Goorhuis
No abstract text is available yet for this article.
December 21, 2016: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/28011234/epidemic-arboviral-diseases-priorities-for-research-and-public-health
#6
REVIEW
Annelies Wilder-Smith, Duane J Gubler, Scott C Weaver, Thomas P Monath, David L Heymann, Thomas W Scott
For decades, arboviral diseases were considered to be only minor contributors to global mortality and disability. As a result, low priority was given to arbovirus research investment and related public health infrastructure. The past five decades, however, have seen an unprecedented emergence of epidemic arboviral diseases (notably dengue, chikungunya, yellow fever, and Zika virus disease) resulting from the triad of the modern world: urbanisation, globalisation, and international mobility. The public health emergency of Zika virus, and the threat of global spread of yellow fever, combined with the resurgence of dengue and chikungunya, constitute a wake-up call for governments, academia, funders, and WHO to strengthen programmes and enhance research in aedes-transmitted diseases...
December 20, 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28006649/serodiagnosis-of-zika-virus-zikv-infections-by-a-novel-ns1-based-elisa-devoid-of-cross-reactivity-with-dengue-virus-antibodies-a-multicohort-study-of-assay-performance-2015-to-2016
#7
Katja Steinhagen, Christian Probst, Christiane Radzimski, Jonas Schmidt-Chanasit, Petra Emmerich, Marjan van Esbroeck, Janke Schinkel, Martin P Grobusch, Abraham Goorhuis, Jens M Warnecke, Erik Lattwein, Lars Komorowski, Andrea Deerberg, Sandra Saschenbrecker, Winfried Stöcker, Wolfgang Schlumberger
Serological diagnosis of Zika virus (ZIKV) infections is challenging due to high cross-reactivity between flaviviruses. We evaluated the diagnostic performance of a novel anti-ZIKV ELISA based on recombinant ZIKV non-structural protein 1 (NS1). Assay sensitivity was examined using sera from 27 patients with reverse transcription (RT)-PCR-confirmed and 85 with suspected ZIKV infection. Specificity was analysed using sera from 1,015 healthy individuals. Samples from 252 patients with dengue virus (n = 93), West Nile virus (n = 34), Japanese encephalitis virus (n = 25), chikungunya virus (n = 19) or Plasmodium spp...
December 15, 2016: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/27983896/how-often-people-google-for-vaccination-qualitative-and-quantitative-insights-from-a-systematic-search-of-the-web-based-activities-using-google-trends
#8
Nicola Luigi Bragazzi, Ilaria Barberis, Roberto Rosselli, Vincenza Gianfredi, Daniele Nucci, Massimo Moretti, Tania Salvatori, Gianfranco Martucci, Mariano Martini
Nowadays, more and more people surf the Internet seeking health-related information. Information and communication technologies (ICTs) can represent an important opportunities in the field of Public Health and vaccinology. The aim of our current research was to investigate a) how often people search the Internet for vaccination-related information, b) if this search is spontaneous or induced by media, and c) which kind of information is in particular searched. We used Google Trends (GT) for monitoring the interest for preventable infections and related vaccines...
December 16, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27982355/detection-of-human-anti-zika-virus-igg-by-elisa-using-an-antigen-from-in-vitro-infected-vero-cells-preliminary-results
#9
Laura Masami Sumita, Jaqueline Polizeli Rodrigues, Noely Evangelista Ferreira, Alvina Clara Felix, Nathalia Caroline Santiago Souza, Clarisse Martins Machado, Heitor Franco de Andrade Júnior
Zika virus (ZKV) infection is a huge public health problem in Brazil because of the increased incidence of microcephaly in neonates from infected mothers. Detection of specific IgG antibodies in maternal serum samples constitutes an important approach for diagnosing ZKV infection and evaluating its relationship with neonatal microcephaly. However, as there is no serological test produced in Brazil to detect IgM and IgG antibodies against ZKV, we sought to examine specific IgG in serum samples from patients or suspected mothers to detect previous infection and to test for specificity with regard to flaviviral infections occurring in the same area...
December 8, 2016: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/27970800/economic-evaluation-of-yellow-fever-routine-vaccination-in-colombia
#10
C Hoestlandt, A Broban, G Houillon, A Caicedo, J F Martinez, A Kieffer
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27960239/histopathology-of-vaccine-preventable-diseases
#11
REVIEW
Isaac H Solomon, Danny A Milner
The widespread use of vaccines has been one of the most important medical advances in the last century, saving trillions of dollars and millions of lives. Despite local eradication of some infections, travellers returning from affected areas may cause outbreaks through reintroduction of pathogens to individuals who are unable to receive vaccines for medical reasons or who have declined vaccination for non-medical reasons. Infections that would otherwise be uncommonly encountered by anatomical pathologists should therefore remain in the differential diagnosis for immunocompromised and unvaccinated patients...
January 2017: Histopathology
https://www.readbyqxmd.com/read/27941965/cd4-cd8-ratio-and-kt-ratio-predict-yellow-fever-vaccine-immunogenicity-in-hiv-infected-patients
#12
Vivian I Avelino-Silva, Karina T Miyaji, Peter W Hunt, Yong Huang, Marisol Simoes, Sheila B Lima, Marcos S Freire, Helio H Caiaffa-Filho, Marisa A Hong, Dayane Alves Costa, Juliana Zanatta C Dias, Natalia B Cerqueira, Anna Shoko Nishiya, Ester Cerdeira Sabino, Ana M Sartori, Esper G Kallas
BACKGROUND: HIV-infected individuals have deficient responses to Yellow Fever vaccine (YFV) and may be at higher risk for adverse events (AE). Chronic immune activation-characterized by low CD4/CD8 ratio or high indoleamine 2,3-dioxygenase-1 (IDO) activity-may influence vaccine response in this population. METHODS: We prospectively assessed AE, viremia by the YFV virus and YF-specific neutralizing antibodies (NAb) in HIV-infected (CD4>350) and -uninfected adults through 1 year after vaccination...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27932620/dissecting-antibodies-induced-by-a-chimeric-yellow-fever-dengue-live-attenuated-tetravalent-dengue-vaccine-cyd-tdv-in-na%C3%A3-ve-and-dengue-exposed-individuals
#13
Sandra Henein, Jesica Swanstrom, Anthony M Byers, Janice M Moser, S Farzana Shaik, Matthew Bonaparte, Nicholas Jackson, Bruno Guy, Ralph Baric, Aravinda M de Silva
Sanofi Pasteur has developed a chimeric yellow fever-dengue, live-attenuated, tetravalent dengue vaccine (CYD-TDV) that is currently approved for use in several countries. In clinical trials, CYD-TDV was efficacious at reducing laboratory-confirmed cases of dengue disease. Efficacy varied by dengue virus (DENV) serotype and pre-vaccination dengue immune status. We compared the properties of antibodies in naïve and DENV exposed individuals who received CYD-TDV. We depleted specific populations of DENV-reactive antibodies from immune sera to estimate the contribution of serotype-cross reactive and type-specific antibodies to neutralization...
December 8, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27928091/a-meta-analysis-of-serological-response-associated-with-yellow-fever-vaccination
#14
Kévin Jean, Christl A Donnelly, Neil M Ferguson, Tini Garske
Despite previous evidence of high level of efficacy, no synthetic metric of yellow fever (YF) vaccine efficacy is currently available. Based on the studies identified in a recent systematic review, we conducted a random-effects meta-analysis of the serological response associated with YF vaccination. Eleven studies conducted between 1965 and 2011 representing 4,868 individual observations were included in the meta-analysis. The pooled estimate of serological response was 97.5% (95% confidence interval [CI] = 82...
December 7, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27928002/adjuvanting-an-siv-vaccine-with-tlr-ligands-encapsulated-in-nanoparticles-induces-persistent-antibody-responses-and-enhanced-protection-in-trim5%C3%AE-restrictive-macaques
#15
Sudhir Pai Kasturi, Pamela A Kozlowski, Helder I Nakaya, Matheus C Burger, Pedro Russo, Mathew Pham, Yevgeniy Kovalenkov, Eduardo L V Silveira, Colin Havenar-Daughton, Samantha L Burton, Katie M Kilgore, Mathew J Johnson, Rafiq Nabi, Traci Legere, Zarpheen Jinnah Sher, Xuemin Chen, Rama R Amara, Eric Hunter, Steven E Bosinger, Paul Spearman, Shane Crotty, Francois Villinger, Cynthia A Derdeyn, Jens Wrammert, Bali Pulendran
: Our previous work has shown that antigens adjuvanted with specific ligands for toll-like receptor 4 (TLR4) and TLR7/8 encapsulated in poly (lactic-co-glycolic acid) (PLGA) based nanoparticles (NP), induced robust and durable immune responses in mice and macaques. We investigated the efficacy of these NP adjuvants in inducing protective immunity against simian immunodeficiency virus (SIV). Rhesus macaques (RMs) were immunized with NP containing TLR4 and TLR7/8 agonists mixed with soluble recombinant SIVmac239 derived envelope (Env) gp140 and Gag p55 (Protein), or with virus like particles (VLP) containing SIVmac239 Env and Gag...
December 7, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27870643/yellow-fever-vaccine-17d-administered-to-healthy-women-aged-between-40-and-54-years-halves-breast-cancer-risk-an-observational-study
#16
Giuseppe Mastrangelo, Sofia Pavanello, Emanuela Fadda, Alessandra Buja, Ugo Fedeli
Transcripts of human endogenous retrovirus K are expressed in most breast cancers (BCs). Yellow fever vaccine 17D (YFV) expresses a protein with a closely homologous epitope. Cross-reactive immunity could hypothetically inhibit BC growth at least in women aged around 50 years at diagnosis, in whom the prognosis of BC was found to be better than that in women younger or older. A cohort of 12 804 women who received YFV in the Veneto Region, Italy, was divided into two subcohorts according to age at vaccination and followed up through the Veneto Tumor Registry...
November 18, 2016: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/27869977/methods-and-procedures-used-in-aedes-aegypti-control-in-the-successful-campaign-for-yellow-fever-prophylaxis-in-rio-de-janeiro-brazil-in-1928-and-1929
#17
Eduardo Dias Wermelinger, Raimundo Wilson de Carvalho
OBJECTIVE: to review the challenges and procedures used in Aedes aegypti control and the characteristics of the epidemics in the successful campaign, led by Clementino Fraga, for yellow fever control in Rio de Janeiro, Brazil, in 1928 and 1929, before the vaccine (1937) and DDT (1947). METHODS: a literature review was conducted by searching official reports, scientific journals and historic textbooks on this subject. RESULTS: the A. aegypti control was achieved through the hard and organized work of breeding site police teams, priority in eliminating breeding sites through environmental management measures and a qualified training program for the teams...
October 2016: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/27869924/yellow-fever-outbreaks-in-s%C3%A3-o-paulo-state-brazil-2000-2010
#18
Leila Del Castillo Saad, Rita Barradas Barata
OBJECTIVE: to describe yellow fever occurrence in the state of São Paulo, Brazil, in the period 2000-2010. METHODS: this was a descriptive study using data regarding human cases, epizootics in non-human primates and virus vector isolation in São Paulo State, between 2000 and 2010. RESULTS: three sylvatic yellow fever outbreaks were registered in the state with 32 human cases and 15 deaths; the cases occurred in unvaccinated individuals exposed to the sylvatic form of transmission; epizootics was confirmed before the virus began circulating in humans in the region of São José do Rio Preto and the virus was isolated twice in vectors...
July 2016: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/27789244/vaccination-against-yellow-fever-in-french-guiana-the-impact-of-educational-level-negative-beliefs-and-attitude-towards-vaccination
#19
Akoï Koïvogui, Aurel Carbunar, Laure-Manuella Imounga, Christelle Laruade, Sylvaine Laube
OBJECTIVE: Analyze the impact of educational level, negative beliefs and negative attitudes on the yellow fever vaccination coverage (YFVC). METHODOLOGY: This analytical study involved a sample of 2763 people from 866 households. Educational status was described in six levels: No level (Respondent had never attended school), level-1 (respondent left before intermediate school), level-2 (Respondent attended intermediate school), level-3 (respondent attended high school), level-4 (Respondent attended university), Other level (When the level could not be determined)...
October 24, 2016: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/27784992/yellow-fever-vaccine-associated-viscerotropic-disease-current-perspectives
#20
REVIEW
Roger E Thomas
PURPOSE: To assess those published cases of yellow fever (YF) vaccine-associated viscerotropic disease that meet the Brighton Collaboration criteria and to assess the safety of YF vaccine with respect to viscerotropic disease. LITERATURE SEARCH: Ten electronic databases were searched with no restriction of date or language and reference lists of retrieved articles. METHODS: All abstracts and titles were independently read by two reviewers and data independently entered by two reviewers...
2016: Drug Design, Development and Therapy
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