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https://www.readbyqxmd.com/read/28719400/dengue-vaccines-implications-for-dengue-control
#1
Matthew L Robinson, Anna P Durbin
PURPOSE OF REVIEW: Dengue, the most common arbovirus, is an increasingly significant cause of morbidity worldwide. After decades of research, an approved tetravalent dengue vaccine is finally available. Models constructed using recently available vaccine efficacy data allow for a data-driven discussion of the potential impact of dengue vaccine deployment on global control. RECENT FINDINGS: Phase 3 efficacy trials demonstrated that the approved dengue vaccine, chimeric yellow fever-dengue-tetravalent dengue vaccine, has an efficacy of 60% against dengue illness of any severity...
July 14, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28716891/which-dengue-vaccine-approach-is-the-most-promising-and-should-we-be-concerned-about-enhanced-disease-after-vaccination-the-path-to-a-dengue-vaccine-learning-from-human-natural-dengue-infection-studies-and-vaccine-trials
#2
Aravinda M de Silva, Eva Harris
Dengue virus (DENV) is the most common arthropod-borne viral disease of humans. Although effective vaccines exist against other flaviviral diseases like yellow fever and Japanese encephalitis, dengue vaccine development is complicated by the presence of four virus serotypes and the possibility of partial immunity enhancing dengue disease severity. Several live attenuated dengue vaccines are being tested in human clinical trials. Initial results are mixed, with variable efficacy depending on DENV serotype and previous DENV exposure...
July 17, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28716884/which-dengue-vaccine-approach-is-the-most-promising-and-should-we-be-concerned-about-enhanced-disease-after-vaccination-the-challenges-of-a-dengue-vaccine
#3
Gavin Screaton, Juthathip Mongkolsapaya
A dengue vaccine has been pursued for more than 50 years and, unlike other flaviviral vaccines such as that against yellow fever, progress has been slow. In this review, we describe progress toward the first licensed dengue vaccine Dengvaxia, which does not give complete protection against disease. The antibody response to the dengue virion is reviewed, highlighting immunodominant yet poorly neutralizing responses in the context of a highly dynamic structurally flexible dengue virus particle. Finally, we review recent evidence for cross-reactivity between antibody responses to Zika and dengue viruses, which may further complicate the development of broadly protective dengue virus vaccines...
July 17, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28698027/access-to-yellow-fever-travel-vaccination-centres-in-england-wales-and-northern-ireland-a-geographical-study
#4
Jakob Petersen, Hilary Simons, Dipti Patel
BACKGROUND: More than 700,000 trips were made by residents in England, Wales, and Northern Ireland (EWNI) in 2015 to tropical countries endemic for yellow fever, a potentially deadly, yet vaccine-preventable disease transmitted by mosquitoes. The aim of this study was to map the geographical accessibility of yellow fever vaccination centres (YFVC) in EWNI. METHODS: The location of 3208 YFVC were geocoded and the average geodetic distance to nearest YFVC was calculated for each population unit...
July 8, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/28689653/who-position-on-the-use-of-fractional-doses-june-2017-addendum-to-vaccines-and-vaccination-against-yellow-fever-who-position-paper-june-2013
#5
World Health Organization
This article presents the World Health Organization's (WHO) recommendations on the use of fractional doses of yellow fever vaccines excerpted from the "Yellow fever vaccine: WHO position on the use of fractional doses - June 2017, Addendum to Vaccines and vaccination against yellow fever WHO: Position Paper - June 2013″, published in the Weekly Epidemiological Record [1,2]. This addendum to the 2013 position paper pertains specifically to use of fractional dose YF (fYF) vaccination (fractional dose yellow fever vaccination refers to administration of a reduced volume of vaccine dose, which has been reconstituted as usual per manufacturer recommendations) in the context of YF vaccine supply shortages beyond the capacity of the global stockpile...
July 6, 2017: Vaccine
https://www.readbyqxmd.com/read/28687661/a-systems-vaccinology-approach-reveals-temporal-transcriptomic-changes-of-immune-responses-to-the-yellow-fever-17d-vaccine
#6
Jue Hou, Shuhui Wang, Manxue Jia, Dan Li, Ying Liu, Zhengpeng Li, Hong Zhu, Huifang Xu, Meiping Sun, Li Lu, Zhinan Zhou, Hong Peng, Qichen Zhang, Shihong Fu, Guodong Liang, Lena Yao, Xuesong Yu, Lindsay N Carpp, Yunda Huang, Julie McElrath, Steve Self, Yiming Shao
In this study, we used a systems vaccinology approach to identify temporal changes in immune response signatures to the yellow fever (YF)-17D vaccine, with the aim of comprehensively characterizing immune responses associated with protective immunity. We conducted a cohort study in which 21 healthy subjects in China were administered one dose of the YF-17D vaccine; PBMCs were collected at 0 h and then at 4 h and days 1, 2, 3, 5, 7, 14, 28, 84, and 168 postvaccination, and analyzed by transcriptional profiling and immunological assays...
July 7, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28666760/vaccination-coverage-among-social-and-healthcare-workers-in-ten-countries-of-samu-social-international-sites
#7
Esaie Marshall, Dominique Salmon, Delphine Laisney, Nadia Bousfiha, Yacouba Togola, François Ouedraogo, Maud Santantonio, Coumba Khadidja Dieng, Suzanne Tartière, Xavier Emmanuelli
BACKGROUND: We aim to determine the vaccination coverage of social and healthcare workers in International sites of Samusocial, providing emergency care to homeless people, and to assess factors associated with having received necessary doses at adulthood. METHODS: Data on immunization coverage of social and healthcare workers were provided by a cross-sectional survey, conducted from February to April 2015 among 252 Samusocial workers in 10 countries. Vaccination status and characteristics of participants were collected through a self-administered questionnaire...
June 27, 2017: Vaccine
https://www.readbyqxmd.com/read/28658271/regulatory-t-cell-frequencies-and-phenotypes-following-anti-viral-vaccination
#8
A Charlotte M T de Wolf, Susan van Aalst, Irene S Ludwig, Caroline L Bodinham, David J Lewis, Ruurd van der Zee, Willem van Eden, Femke Broere
Regulatory T cells (Treg) function in the prevention of excessive inflammation and maintenance of immunological homeostasis. However, these cells may also interfere with resolution of infections or with immune reactions following vaccination. Effects of Treg on vaccine responses are nowadays investigated, but the impact of vaccination on Treg homeostasis is still largely unknown. This may be a relevant safety aspect, since loss of tolerance through reduced Treg may trigger autoimmunity. In exploratory clinical trials, healthy adults were vaccinated with an influenza subunit vaccine plus or minus the adjuvant MF59®, an adjuvanted hepatitis B subunit vaccine or a live attenuated yellow fever vaccine...
2017: PloS One
https://www.readbyqxmd.com/read/28643507/yellow-fever-vaccine-who-position-on-the-use-of-fractional-doses-%C3%A2-june-2017
#9
(no author information available yet)
No abstract text is available yet for this article.
June 23, 2017: Relevé épidémiologique Hebdomadaire
https://www.readbyqxmd.com/read/28637753/structural-mimicry-of-the-dengue-virus-envelope-glycoprotein-revealed-by-the-crystallographic-study-of-an-idiotype-anti-idiotype-fab-complex
#10
Yee Hwa Wong, Boon Chong Goh, She Yah Lim, En Wei Teo, Angeline P C Lim, Pete C Dedon, Brendon J Hanson, Paul A MacAry, Julien Lescar
A detailed understanding of the fine specificity of serotype-specific human antibodies is vital for the development and evaluation of new vaccines for pathogenic Flaviviruses such as Dengue virus (DENV) and Zika virus. In this study, we thoroughly characterize the structural footprint of an anti-idiotype antibody (E1) specific for a potent, fully human DENV serotype 1-specific antibody termed HM14c10, derived from a recovered patient. The crystal structure at a resolution of 2.5 Å of a complex between the Fab fragments of E1 and HM14c10 provides the first detailed molecular comparison of an anti-idiotype paratope specific for a human antibody with its analogous epitope- a discontinuous quaternary structure located at the surface of the viral particle that spans adjacent envelope (E) proteins...
June 21, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28623054/detection-of-yellow-fever-virus-genomes-from-four-imported-cases-in-china
#11
Shujuan Cui, Yang Pan, Yanning Lyu, Zhichao Liang, Jie Li, Yulan Sun, Xiangfeng Dou, Lili Tian, Da Huo, Lijuan Chen, Xinyu Li, Quanyi Wang
Yellow fever virus (YFV), as the first proven human-pathogenic virus, is still a major public health problem with a dramatic upsurge in recent years. This is a report on four imported cases of yellow fever virus into China identified by whole genome sequencing. Phylogenetic analysis was performed and the results showed that these four viruses were highly homologous with Angola 71 strains (AY968064). In addition, effective mutations of amino acids were not observed in the E protein domain of four viruses, thus confirming the effectiveness of the YFV-17D vaccine (X03700)...
July 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28619415/international-travelers-sociodemographic-health-and-travel-characteristics-an-italian-study
#12
Gianmarco Troiano, Astrid Mercone, Alessandra Bagnoli, Nicola Nante
BACKGROUND: Approximately the 8% of travelers requires medical care, with the diagnosis of a vaccine-preventable disease. The aim of our study was to analyze the socio-demographic, health and travel characteristics of the Italian international travelers. METHODS: We conducted a cross sectional study from January 2015 to June 2016, at the Travel Medicine Clinic of Siena, asking the doctor to interview patients who attended the Clinic, recording socio-demographic and travel information, malaria prophylaxis, vaccinations...
March 2017: Annals of Global Health
https://www.readbyqxmd.com/read/28616878/lichen-striatus-following-yellow-fever-vaccination-in-an-adult-woman
#13
M Karouni, M Kurban, O Abbas
No abstract text is available yet for this article.
June 14, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28591405/genome-analysis-of-yellow-fever-virus-of-the-ongoing-outbreak-in-brazil-reveals-polymorphisms
#14
Myrna C Bonaldo, Mariela Martínez Gómez, Alexandre Ac Dos Santos, Filipe Vieira Santos de Abreu, Anielly Ferreira-de-Brito, Rafaella Moraes de Miranda, Marcia Gonçalves de Castro, Ricardo Lourenço-de-Oliveira
The current yellow fever outbreak in Brazil is the most severe one in the country in recent times. It has rapidly spread to areas where YF virus (YFV) activity has not been observed for more than 70 years and vaccine coverage is almost null. Here, we sequenced the whole YFV genome of two naturally infected howler-monkeys (Alouatta clamitans) obtained from the Municipality of Domingos Martins, state of Espírito Santo, Brazil. These two ongoing-outbreak genome sequences are identical. They clustered in the 1E sub-clade (South America genotype I) along with the Brazilian and Venezuelan strains recently characterised from infections in humans and non-human primates that have been described in the last 20 years...
June 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28577343/de-novo-rna-synthesis-catalyzed-by-the-zika-virus-rna-polymerase-domain
#15
Christina Calmels, Michel Ventura, Cindy Aknin, Mathieu Métifiot, Marie-Line Andreola
Mosquito- and tick-borne pathogens including Chikungunya, Dengue, Japanese encephalitis, West Nile, Yellow fever and Zika virus, represent a new economic and public health challenge. In the absence of effective vaccines and specific therapies, only supportive regimens are administrated for most of these infections. Thus, the development of a targeted therapy is mandatory to stop the rapid progression of these pathogens and preoccupant associated burdens such as Guillain-Barre syndrome, microcephaly. For this, it is essential to develop biochemical tools to help study and target key viral enzymes involved in replication such as helicase complexes, methyl-transferases and RNA-dependent RNA polymerases...
June 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28574621/prospects-for-induction-of-cd8-t-cell-mediated-immunity-to-zika-virus-infection-by-yellow-fever-virus-vaccination
#16
K Blom, J T Sandberg, K Loré, H-G Ljunggren
No abstract text is available yet for this article.
June 2, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28562615/screening-test-for-neutralizing-antibodies-against-yellow-fever-virus-based-on-a-flavivirus-pseudotype
#17
Séverine Mercier-Delarue, Christine Durier, Nathalie Colin de Verdière, Jean-Dominique Poveda, Vincent Meiffrédy, Maria Dolores Fernandez Garcia, Stéphane Lastère, Raymond Césaire, Jean-Claude Manuggera, Jean-Michel Molina, Ali Amara, François Simon
Given the possibility of yellow fever virus reintroduction in epidemiologically receptive geographic areas, the risk of vaccine supply disruption is a serious issue. New strategies to reduce the doses of injected vaccines should be evaluated very carefully in terms of immunogenicity. The plaque reduction test for the determination of neutralizing antibodies (PRNT) is particularly time-consuming and requires the use of a confinement laboratory. We have developed a new test based on the use of a non-infectious pseudovirus (WN/YF17D)...
2017: PloS One
https://www.readbyqxmd.com/read/28560654/newer-vaccines-against-mosquito-borne-diseases
#18
Anju Aggarwal, Neha Garg
Mosquitos are responsible for a number of protozoal and viral diseases. Malaria, dengue, Japanese encephalitis (JE) and chikungunya epidemics occur commonly all over the world, leading to marked mortality and morbidity in children. Zika, Yellow fever and West Nile fever are others requiring prevention. Environmental control and mosquito bite prevention are useful in decreasing the burden of disease but vaccination has been found to be most cost-effective and is the need of the hour. RTS,S/AS01 vaccine is the first malaria vaccine being licensed for use against P...
May 31, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28553618/effective-protection-induced-by-a-monovalent-dna-vaccine-against-dengue-virus-dv-serotype-1-and-a-bivalent-dna-vaccine-against-dv1-and-dv2-in-mice
#19
Xiaoyan Zheng, Hui Chen, Ran Wang, Dongying Fan, Kaihao Feng, Na Gao, Jing An
Dengue virus (DV) is the causal pathogen of dengue fever, which is one of the most rapidly spread mosquito-borne disease worldwide and has become a severe public health problem. Currently, there is no specific treatment for dengue; thus, a vaccine would be an effective countermeasure to reduce the morbidity and mortality. Although, the chimeric Yellow fever dengue tetravalent vaccine has been approved in some countries, it is still necessary to develop safer, more effective, and less costly vaccines. In this study, a DNA vaccine candidate pVAX1-D1ME expressing the prME protein of DV1 was inoculated in BALB/c mice via intramuscular injection or electroporation, and the immunogenicity and protection were evaluated...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28529708/yellow-fever-in-the-americas-the-growing-concern-about-new-epidemics
#20
Yeimer Ortiz-Martínez, Andrés Mauricio Patiño-Barbosa, Alfonso J Rodriguez-Morales
Yellow fever (YF) is a haemorrhagic viral disease with a high case fatality rate. It is considered a reemerging infectious disease of remarkable importance. During the last outbreaks in Angola (2015-2016) and Brazil (2016-2017), many cases of YF emerged despite high YF vaccination coverage, increasing the risk of major epidemics in the Americas. Several factors, including the vast border and migratory status of Brazil, the widespread distribution of Aedes mosquitoes and the lack of efficient health policies and surveillance systems, favour this complex epidemiological scenario of reemergence...
2017: F1000Research
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