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https://www.readbyqxmd.com/read/29773321/evaluating-scenarios-of-locations-and-capacities-for-vaccine-storage-in-nigeria
#1
Dor Hirsh Bar Gai, Zachary Graybill, Paule Voevodsky, Ekundayo Shittu
Many developing countries still face the prevalence of preventable childhood diseases because their vaccine supply chain systems are inadequate by design or structure to meet the needs of their populations. Currently, Nigeria is evaluating options in the redesign of the country's vaccine supply chain. Using Nigeria as a case study, the objective is to evaluate different regional supply chain scenarios to identify the cost minimizing optimal hub locations and storage capacities for doses of different vaccines to achieve a 100% fill rate...
May 14, 2018: Vaccine
https://www.readbyqxmd.com/read/29757218/detection-of-specific-zikv-igm-in-travelers-using-a-multiplexed-flavivirus-microsphere-immunoassay
#2
Carmel T Taylor, Ian M Mackay, Jamie L McMahon, Sarah L Wheatley, Peter R Moore, Mitchell J Finger, Glen R Hewitson, Frederick A Moore
Zika virus (ZIKV) has spread widely in the Pacific and recently throughout the Americas. Unless detected by RT-PCR, confirming an acute ZIKV infection can be challenging. We developed and validated a multiplexed flavivirus immunoglobulin M (IgM) microsphere immunoassay (flaviMIA) which can differentiate ZIKV-specific IgM from that due to other flavivirus infections in humans. The flaviMIA bound 12 inactivated flavivirus antigens, including those from ZIKV and yellow fever virus (YFV), to distinct anti-flavivirus antibody coupled beads...
May 12, 2018: Viruses
https://www.readbyqxmd.com/read/29751350/development-of-a-non-destructive-method-for-determining-protein-nitrogen-in-a-yellow-fever-vaccine-by-near-infrared-spectroscopy-and-multivariate-calibration
#3
Vanessa Emídio Dabkiewicz, Shirley de Mello Pereira Abrantes, Ricardo Jorgensen Cassella
Near infrared spectroscopy (NIR) with diffuse reflectance associated to multivariate calibration has as main advantage the replacement of the physical separation of interferents by the mathematical separation of their signals, rapidly with no need for reagent consumption, chemical waste production or sample manipulation. Seeking to optimize quality control analyses, this spectroscopic analytical method was shown to be a viable alternative to the classical Kjeldahl method for the determination of protein nitrogen in yellow fever vaccine...
April 24, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29743363/comparative-characterization-of-the-sindbis-virus-proteome-from-mammalian-and-invertebrate-hosts-identifies-nsp2-as-a-component-of-the-virus-nucleocapsid-and-sorting-nexin-5-as-a-significant-host-factor-for-alphavirus-replication
#4
Ryan Schuchman, Andy Kilianski, Amanda Piper, Ricardo Vancini, José M C Ribeiro, Thomas R Sprague, Farooq Nasar, Gabrielle Boyd, Raquel Hernandez, Trevor Glaros
Recent advances in mass spectrometry methods and instrumentation now allow for more accurate identification of proteins in low abundance. This technology was applied to Sindbis virus, the prototypical alphavirus to investigate the viral proteome. To determine if host proteins are specifically packaged into alphavirus virions, Sindbis virus (SINV) was grown in multiple host cells representing vertebrate and mosquito hosts and total protein content of purified virions was determined. This analysis identified host factors not previously associated with alphavirus entry, replication, or egress...
May 9, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29723485/late-or-lack-of-vaccination-linked-to-importation-of-yellow-fever-from-angola-to-china
#5
Rui Song, Shengcan Guan, Shui Shan Lee, Zhihai Chen, Chen Chen, Lifen Han, Yanli Xu, Ang Li, Hui Zeng, Hanhui Ye, Fujie Zhang
During March and April 2016, 11 yellow fever cases were identified in China. We report epidemic and viral information for 10 of these patients, 6 of whom had been vaccinated before travel. Phylogenetic analyses suggest these viruses nested within the diversity of strains endemic to Angola, where an outbreak began in 2015.
July 17, 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29706291/characterization-of-recombinant-yellow-fever-dengue-vaccine-viruses-with-human-monoclonal-antibodies-targeting-key-conformational-epitopes
#6
Valerie Lecouturier, Catherine Berry, Aure Saulnier, Sophie Naville, Catherine Manin, Yves Girerd-Chambaz, James E Crowe, Nicholas Jackson, Bruno Guy
The recombinant yellow fever-17D-dengue virus, live, attenuated, tetravalent dengue vaccine (CYD-TDV) is licensed in several dengue-endemic countries. Although the vaccine provides protection against dengue, the level of protection differs by serotype and warrants further investigation. We characterized the antigenic properties of each vaccine virus serotype using highly neutralizing human monoclonal antibodies (hmAbs) that bind quaternary structure-dependent epitopes. Specifically, we monitored the binding of dengue virus-1 (DENV-1; 1F4), DENV-2 (2D22) or DENV-3 (5J7) serotype-specific or DENV-1-4 cross-reactive (1C19) hmAbs to the four chimeric yellow fever-dengue vaccine viruses (CYD-1-4) included in phase III vaccine formulations using a range of biochemical and functional assays (dot blot, ELISA, surface plasmon resonance and plaque reduction neutralization assays)...
April 26, 2018: Vaccine
https://www.readbyqxmd.com/read/29688492/adverse-events-in-vaccinations-for-travelers-a-1-year-prospective-survey-in-a-travel-clinic-in-germany
#7
Günther Slesak, Ralf Fleck, Helmut Scherbaum, Gunnar Blumenstock, Johannes Schäfer
Background: The study goal was to assess and compare adverse events (AE) of current vaccinations for travelers under 'real-life conditions'. Methods: A prospective observational online questionnaire study was performed from May 2015 till April 2016 in a travel clinic in Germany. Online questionnaire links were sent 1 week after the first vaccination date. Severity was rated on a scale from 1 to 5 (minor to very severe AE). Results: Of 1357 vaccinees 781 (57...
January 1, 2018: Journal of Travel Medicine
https://www.readbyqxmd.com/read/29666784/the-immune-responses-of-the-animal-hosts-of-west-nile-virus-a-comparison-of-insects-birds-and-mammals
#8
REVIEW
Laura R H Ahlers, Alan G Goodman
Vector-borne diseases, including arboviruses, pose a serious threat to public health worldwide. Arboviruses of the flavivirus genus, such as Zika virus (ZIKV), dengue virus, yellow fever virus (YFV), and West Nile virus (WNV), are transmitted to humans from insect vectors and can cause serious disease. In 2017, over 2,000 reported cases of WNV virus infection occurred in the United States, with two-thirds of cases classified as neuroinvasive. WNV transmission cycles through two different animal populations: birds and mosquitoes...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29665797/estimating-the-number-of-unvaccinated-chinese-workers-against-yellow-fever-in-angola
#9
A Wilder-Smith, E Massad
BACKGROUND: A yellow fever epidemic occurred in Angola in 2016 with 884 laboratory confirmed cases and 373 deaths. Eleven unvaccinated Chinese nationals working in Angola were also infected and imported the disease to China, thereby presenting the first importation of yellow fever into Asia. In Angola, there are about 259,000 Chinese foreign workers. The fact that 11 unvaccinated Chinese workers acquired yellow fever suggests that many more Chinese workers in Angola were not vaccinated...
April 17, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29659924/evaluation-of-a-booster-dose-of-pentavalent-rotavirus-vaccine-co-administered-with-measles-yellow-fever-and-meningitis-a-vaccines-in-9-month-old-malian-infants
#10
Fadima C Haidara, Milagritos D Tapia, Samba O Sow, Moussa Doumbia, Flanon Coulibaly, Fatoumata Diallo, Awa Traoré, Mamoudou Kodio, Corey L Kelly, Meagan Fitzpatrick, Karen Kotloff, John C Victor, Kathleen Neuzil
Background: Rotavirus vaccines given to infants are safe and efficacious. A booster dose of rotavirus vaccine could extend protection into the second year of life in low resource countries. Methods: We conducted an open-label, individual-randomized trial in Bamako, Mali. We assigned 600 9- to 11-month old infants to measles (MV), yellow fever (YFV), and meningococcal A conjugate vaccines with or without pentavalent rotavirus vaccine (PRV). We assessed non-inferiority of seroconversion and seroresponse rates (<10% difference) to MV, YFV and MenAV...
April 12, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29643198/development-of-a-real-time-rt-pcr-assay-for-the-global-differentiation-of-yellow-fever-virus-vaccine-adverse-events-from-natural-infections
#11
Holly R Hughes, Brandy J Russell, Eric C Mossel, John Kayiwa, Julius Lutwama, Amy J Lambert
Yellow fever (YF) is a reemerging public health threat with frequent outbreaks prompting large vaccination campaigns in endemic regions of Africa and South America. Specific detection of vaccine-related adverse events is resource-intensive, time-consuming and difficult to achieve during an outbreak. To address this, we have developed a highly transferable, rapid yellow fever virus (YFV) vaccine-specific real-time RT-PCR assay that distinguishes vaccine from wild-type lineages. The assay utilizes a specific hydrolysis probe that includes locked nucleic acids to enhance specific discrimination of the YFV 17D vaccine strain genome...
April 11, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29617280/oropouche-fever-a-review
#12
REVIEW
Hercules Sakkas, Petros Bozidis, Ashley Franks, Chrissanthy Papadopoulou
Oropouche fever is an emerging zoonotic disease caused by Oropouche virus (OROV), an arthropod transmitted Orthobunyavirus circulating in South and Central America. During the last 60 years, more than 30 epidemics and over half a million clinical cases attributed to OROV infection have been reported in Brazil, Peru, Panama, Trinidad and Tobago. OROV fever is considered the second most frequent arboviral febrile disease in Brazil after dengue fever. OROV is transmitted through both urban and sylvatic transmission cycles, with the primary vector in the urban cycle being the anthropophilic biting midge Culicoides paraensis ...
April 4, 2018: Viruses
https://www.readbyqxmd.com/read/29584837/vaccination-strategies-during-shortages-of-yellow-fever-vaccine-reply
#13
Lin H Chen, Davidson H Hamer
No abstract text is available yet for this article.
March 27, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29584835/vaccination-strategies-during-shortages-of-yellow-fever-vaccine
#14
Scott A Norton, David M Morens
No abstract text is available yet for this article.
March 27, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29580693/innovative-in-cellulo-method-as-an-alternative-to-in-vivo-neurovirulence-test-for-the-characterization-and-quality-control-of-human-live-yellow-fever-virus-vaccines-a-pilot-study
#15
Anaelle da Costa, Christophe Prehaud, Cecile Khou, Nathalie Pardigon, Aure Saulnier, Nolwenn Nougarede, Monique Lafon
Live attenuated vaccines have proved to be mostly valuable in the prevention of infectious diseases in humans, especially in developing countries. The safety and potency of vaccine, and the consistency of vaccine batch-to-batch manufacturing, must be proven before being administrated to humans. For now, the tests used to control vaccine safety largely involve animal testing. For live viral vaccines, regulations require suppliers to demonstrate the absence of neurovirulence in animals, principally in non-human primates and mice...
March 23, 2018: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/29580643/japanese-encephalitis-virus-yellow-fever-virus-chimera-is-safe-and-confers-full-protection-against-yellow-fever-virus-in-intracerebrally-challenged-mice
#16
Huiqiang Yang, Huan Yang, Zhushi Li, Lina Liu, Wei Wang, Ting He, Fengming Fan, Yan Sun, Jie Liu, Yuhua Li, Xianwu Zeng
Yellow fever (YF) is an acute viral haemorrhagic disease caused by the yellow fever virus (YFV), which remains a potential threat to public health. The live-attenuated YF vaccine (17D strain) is a safe and highly effective measure against YF. However, increasing adverse events have been associated with YF vaccinations in recent years; thus, safer, alternative vaccines are needed. In this study, using the Japanese encephalitis live vaccine strain SA14-14-2 as a backbone, a novel chimeric virus was constructed by replacing the pre-membrane (prM) and envelope (E) genes with their YFV 17D counterparts...
April 25, 2018: Vaccine
https://www.readbyqxmd.com/read/29567514/development-of-an-anti-dengue-ns1-igg-elisa-to-evaluate-exposure-to-dengue-virus
#17
Eduardo J M Nascimento, James K George, Melissa Velasco, Matthew I Bonaparte, Lingyi Zheng, Carlos DiazGranados, Ernesto T A Marques, James W Huleatt
Dengue virus infection elicits immune responses to multiple viral antigens including antibodies to dengue non-structural protein 1 (NS1) which are rapidly induced and detected within days of infection. The recombinant, live, attenuated, tetravalent dengue vaccine (CYD-TDV; Sanofi Pasteur) uses the yellow fever vaccine virus as a back-bone but expresses dengue virus pre-membrane and envelop proteins. Since CYD-TDV does not express dengue NS1, we evaluated the utility of dengue NS1-specific IgG antibodies as biomarkers of dengue exposure in CYD-TDV recipients and controls...
March 19, 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/29565840/fatal-yellow-fever-in-travelers-to-brazil-2018
#18
Davidson H Hamer, Kristina Angelo, Eric Caumes, Perry J J van Genderen, Simin A Florescu, Corneliu P Popescu, Cecilia Perret, Angela McBride, Anna Checkley, Jenny Ryan, Martin Cetron, Patricia Schlagenhauf
Yellow fever virus is a mosquito-borne flavivirus that causes yellow fever, an acute infectious disease that occurs in South America and sub-Saharan Africa. Most patients with yellow fever are asymptomatic, but among the 15% who develop severe illness, the case fatality rate is 20%-60%. Effective live-attenuated virus vaccines are available that protect against yellow fever (1). An outbreak of yellow fever began in Brazil in December 2016; since July 2017, cases in both humans and nonhuman primates have been reported from the states of São Paulo, Minas Gerais, and Rio de Janeiro, including cases occurring near large urban centers in these states (2)...
March 23, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29560853/increased-risk-of-yellow-fever-infections-among-unvaccinated-european-travellers-due-to-ongoing-outbreak-in-brazil-july-2017-to-march-2018
#19
Céline M Gossner, Joana M Haussig, Chiara de Bellegarde de Saint Lary, Kaja Kaasik Aaslav, Patricia Schlagenhauf, Bertrand Sudre
Since December 2016, Brazil has faced a large outbreak of yellow fever with ca 1,500 confirmed human cases. In the first 2 months of 2018, Brazil reported almost as many cases as in 2017 as a whole. In these 2 months, five imported cases were reported among unvaccinated European travellers. Three had travelled to Ilha Grande, a popular destination among European tourists. Physicians and European travellers visiting Brazil should follow yellow fever vaccination recommendations.
March 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29553795/applicability-of-the-monocyte-activation-test-mat-in-the-quality-control-of-the-17dd-yellow-fever-vaccine
#20
Katherine Antunes de Mattos, Elaine Cristina Azevedo Navega, Vitor Fernandes Silva, Alessandra Santos Almeida, Cristiane Caldeira da Silva, Octavio Augusto França Presgrave, Daniel da Silva Guedes Junior, Isabella Fernandes Delgado
The need for alternatives to animal use in pyrogen testing has been driven by the Three Rs concept. This has resulted in the inclusion of the monocyte activation test (MAT) in the European Pharmacopoeia, 2010. However, some technical and regulatory obstacles must be overcome to ensure the effective implementation of the MAT by the industry, especially for the testing of biological products. The yellow fever (YF) vaccine (17DD-YFV) was chosen for evaluation in this study, in view of: a) the 2016-2018 outbreak of YF in Brazil; b) the increase in demand for 17DD-YFV doses; c) the complex production process with live attenuated virus; d) the presence of possible test interference factors, such as residual process components (e...
March 2018: Alternatives to Laboratory Animals: ATLA
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