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https://www.readbyqxmd.com/read/29471605/-emerging-therapies-what-are-promising-in-the-near-future
#1
REVIEW
Geom Seog Seo, Sung Hee Lee
The treatment of inflammatory bowel disease has evolved with the development of anti-TNF agents. In spite of long-term effectiveness, many patients do not respond or no longer responds to these drugs. Therefore, the development of new drugs that act on different inflammatory pathways has become necessary. Vedolizumab, a gut-specific biological agent, inhibits interaction α4β7 integrin with mucosal addressin cell adhesion molecule-1 without inhibiting systemic immune responses. Long-term vedolizumab therapy in patients with Crohn's disease and ulcerative colitis was safe and effective...
February 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29471502/elevated-g6pd-expression-contributes-to-migration-and-invasion-of-hepatocellular-carcinoma-cells-by-inducing-epithelial-mesenchymal-transition
#2
Ming Lu, Lu Lu, Qiongzhu Dong, Guangyang Yu, Jinhong Chen, Lunxiu Qin, Lianxin Wang, Wenwei Zhu, Huliang Jia
Altered metabolism is one of the hallmarks of cancer cells. Pentose phosphate pathway (PPP) is a fundamental component of cellular metabolism. Glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the PPP, is elevated in many cancers and contributes to tumor growth by producing ribose-5-phosphate and NADPH through PPP. However, the role of G6PD in hepatocellular carcinoma (HCC) metastasis and the clinical significance of G6PD in HCC progression and prognosis have not been well determined. In this study, by investigating tissue samples from HCC patients and HCC cell lines, we found that elevated G6PD expression is significantly associated with HCC metastasis and poor prognosis of HCCs, and that knockdown of G6PD inhibits in vitro proliferation, migration and invasion of HCC cell lines...
February 17, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29471397/a-conceptual-framework-the-musical-self-as-a-unique-pathway-to-outcomes-in-the-acute-pediatric-health-setting
#3
Helen Shoemark, Jo Rimmer, Janeen Bower, Belinda Tucquet, Lauren Miller, Michelle Fisher, Nicholas Ogburn, Beth Dun
This article reports on a project at the Royal Children's Hospital Melbourne in which the music therapy team synthesized their practice and related theories to propose a new conceptual framework for music therapy in their acute pediatric setting. The impetus for the project was the realization that in the process of producing key statements about the non-musical benefits of music therapy, the cost was often the suppression of information about the patient's unique musical potential as the major (mediating) pathway from referral reason, to music therapy, and to effective outcomes...
February 17, 2018: Journal of Music Therapy
https://www.readbyqxmd.com/read/29471368/human-factors-risk-analyses-of-a-doffing-protocol-for-ebola-level-personal-protective-equipment-mapping-errors-to-contamination
#4
Joel M Mumma, Francis T Durso, Ashley N Ferguson, Christina L Gipson, Lisa Casanova, Kimberly Erukunuakpor, Colleen S Kraft, Victoria L Walsh, Craig Zimring, Jennifer DuBose, Jesse T Jacob
Background: Doffing protocols for personal protective equipment (PPE) are critical for keeping healthcare workers (HCWs) safe during care of patients with Ebola virus disease. We assessed the relationship between errors and self-contamination during doffing. Methods: Eleven HCWs experienced with doffing Ebola-level PPE participated in simulations in which HCWs donned PPE marked with surrogate viruses (ɸ6 and MS2), completed a clinical task, and were assessed for contamination after doffing...
February 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29471294/novel-familial-variant-of-the-desert-hedgehog-gene-clinical-findings-in-two-sisters-with-46-xy-gonadal-dysgenesis-or-46-xx-karyotype-and-literature-review
#5
Fulvia Baldinotti, Tiziana Cavallaro, Eleonora Dati, Giampiero I Baroncelli, Veronica Bertini, Angelo Valetto, Francesco Massart, Gian Maria Fabrizi, Giampietro Zanette, Diego Peroni, Silvano Bertelloni
BACKGROUND: In humans, Desert Hedgehog (DHH) gene mutations are a very rare cause of 46,XY gonadal dysgenesis (GD), eventually associated with peripheral neuropathy. PATIENTS AND METHODS: Clinical records of 12 patients with 46,XY GD and unknown genetic background were reviewed and a 46,XY woman with peripheral neuropathy was individuated. Her 46,XX sister affected by similar neuropathy was also investigated. Genomic DNA was extracted and DHH exons sequenced and analyzed...
February 22, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29471035/how-safe-is-the-safety-net-comparison-of-ivor-lewis-esophagectomy-at-a-safety-net-hospital-using-the-nsqip-database
#6
Lori A Gurien, Joseph J Tepas, D Scott Lind, David J Chesire, Michel J Sabra, Brian Ga Dalton, Ziad T Awad
BACKGROUND: Recent data suggest that surgical outcomes at hospitals caring for low-income, vulnerable populations are suboptimal compared to non safety net hospitals. Therefore, the purpose of our study was to compare outcomes for patients who underwent an Ivor-Lewis esophagectomy at a safety net hospital with the National Surgical Quality Improvement Program (NSQIP) database. STUDY DESIGN: We retrospectively reviewed the medical records of consecutive patients who underwent an Ivor-Lewis esophagectomy from September 2013 to January 2017 at a single safety net hospital...
January 21, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29470683/clinical-significance-of-the-2016-who-classification-in-japanese-patients-with-gliomas
#7
Toshihiko Iuchi, Takahiro Sugiyama, Miki Ohira, Hajime Kageyama, Sana Yokoi, Tsukasa Sakaida, Yuzo Hasegawa, Taiki Setoguchi, Makiko Itami
In this study, we retrospectively compared the prognostic value of the 2016 WHO classification with the former classification in 387 patients with glioma treated at our institution. According to the new classification, diagnoses included oligodendroglioma with isocitrate dehydrogenase (IDH) mutation and 1p/19q co-deletion (5.4%), anaplastic oligodendroglioma with IDH mutation and 1p/19q co-deletion (3.4%), diffuse astrocytoma IDH-mutated (3.9%), anaplastic astrocytoma IDH-mutated (2.8%), glioblastoma IDH-mutated (7...
February 22, 2018: Brain Tumor Pathology
https://www.readbyqxmd.com/read/29470654/-molecular-characterization-of-penile-cancer-literature-review-of-new-prognostic-markers-and-potential-therapeutic-targets
#8
REVIEW
M May, S D Brookman-May, T H Ecke, M Burger
Squamous cell carcinoma of the penis (SCCP) is a rare cancer type in Western industrialized nations; nevertheless, it shows an aggressive course of disease in advanced tumor stages with accordantly high recurrence and progression rates. While molecular biomarkers are not established in clinical routine for the management of SCCP patients yet, the accordant unmet need is enormous, as adequate biomarkers would be meaningful for prognostic determination, planning of modality and extent of primary therapy, indication for inguinal lymph node resection, adjuvant treatment, and as potential targets for specific systemic treatment...
February 22, 2018: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29470537/microsomal-prostaglandin-e-synthase-1-gene-deletion-impairs-neuro-immune-circuitry-of-the-cholinergic-anti-inflammatory-pathway-in-endotoxaemic-mouse-spleen
#9
Priya Revathikumar, Johanna Estelius, Utsa Karmakar, Erwan Le Maître, Marina Korotkova, Per-Johan Jakobsson, Jon Lampa
The cholinergic anti-inflammatory pathway (CAP) is an innate neural reflex where parasympathetic and sympathetic nerves work jointly to control inflammation. Activation of CAP by vagus nerve stimulation (VNS) has paved way for novel therapeutic strategies in treating inflammatory diseases. Recently, we discovered that VNS mediated splenic acetylcholine (ACh) release and subsequent immunosuppression in response to LPS associated inflammation is impaired in mice lacking microsomal prostaglandin E synthase-1 (mPGES-1) expression, a key enzyme responsible for prostaglandin E2 synthesis...
2018: PloS One
https://www.readbyqxmd.com/read/29470436/neurobiology-of-propofol-addiction-and-supportive-evidence-what-is-the-new-development
#10
REVIEW
Ming Xiong, Nimisha Shiwalkar, Kavya Reddy, Peter Shin, Alex Bekker
Propofol is a short-acting intravenous anesthetic agent suitable for induction and maintenance of general anesthesia as well as for procedural and intensive care unit sedation. As such it has become an unparalleled anesthetic agent of choice in many institutional and office practices. However, in addition to its idealistic properties as an anesthetic agent, there is accumulating evidence suggesting its potential for abuse. Clinical and experimental evidence has revealed that not only does propofol have the potential to be abused, but also that addiction to propofol shows a high mortality rate...
February 22, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29470361/early-heterogenic-response-of-renal-microvasculature-to-hemorrhagic-shock-resuscitation-and-the-influence-of-nf-%C3%AE%C2%BAb-pathway-blockade
#11
Rui Yan, Matijs van Meurs, Eliane R Popa, Ranran Li, Peter J Zwiers, Jan G Zijlstra, Jill Moser, Grietje Molema
Hemorrhagic shock (HS) is associated with low blood pressure due to excessive loss of circulating blood and causes both macrocirculatory and microcirculatory dysfunction. Fluid resuscitation after HS is used in the clinic to restore tissue perfusion. The persistent microcirculatory damage caused by HS and/or resuscitation can result in multiple organ damage, with the kidney being one of the involved organs. The kidney microvasculature consists of different segments that possess a remarkable heterogeneity in functional properties...
February 21, 2018: Shock
https://www.readbyqxmd.com/read/29470277/does-duration-of-pain-at-baseline-influence-clinical-outcomes-of-low-back-pain-patients-managed-on-an-evidence-based-pathway
#12
Mary-Anne Jess, Ryan Cormac, Sharon Hamilton, Shaun Wellburn, Greg Atkinson, Charles Greenough, Andrew Coxon, Diarmaid Ferguson, Francis Fatoye, John Dickson, Andrea Jones, Denis Martin
Supplemental Digital Content is available in the text STUDY DESIGN.: Longitudinal observational study. OBJECTIVE: To investigate the association between the duration of pain at baseline and the clinical outcomes of patients with low back pain (LBP) enrolled on the North East of England Regional Back Pain and Radicular Pain Pathway (NERBPP). SUMMARY OF BACKGROUND DATA: The NERBPP is a clinical pathway based upon NICE guidelines (2009) for LBP of <1-year duration...
February 21, 2018: Spine
https://www.readbyqxmd.com/read/29470255/clinical-implications-of-oncogenic-mutations-in-pulmonary-langerhans-cell-histiocytosis
#13
Noah A Brown, Kojo S J Elenitoba-Johnson
PURPOSE OF REVIEW: Langerhans cell histiocytosis (LCH) is a neoplasm of dendritic cells with a wide clinical spectrum. Localized pulmonary LCH occurs in young adults with a history of smoking and can either resolve spontaneously or lead to progressive decline in pulmonary function. Young children can also present with localized disease - frequently bone or skin - or with multifocal or multisystem disease. Clinical outcomes in these patients also vary widely, ranging from spontaneous resolution to multiorgan failure and death...
February 20, 2018: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29470187/the-danish-gynecological-cancer-nursing-database-creating-evidence-for-quality-improvements-in-preoperative-and-postoperative-cancer-care
#14
Lene Seibæk, Dorthe Hjort Jakobsen, Claus Høgdall
OBJECTIVE: Quality of preoperative and postoperative care is crucial to improve postoperative outcome of cancer surgery and to ensure that neither complications nor a poor general condition delays any subsequent radiochemotherapy or recovery. On this background, the Danish Gynecological Cancer Database (DGCD) established a nursing database in 2011. The aim of DGCD Nursing is to monitor the quality of preoperative and postoperative care and to generate data for research. MATERIAL AND METHODS: In accordance with the current data protection legislation, real-time data are entered by clinical nurses at all national cancer centers...
February 22, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29469990/differential-metabolic-pathway-analysis-of-the-proteomes-of-leishmania-donovani-and-leptomonas-seymouri
#15
Neeloo Singh, Renu Goel, Ekta Jain
PURPOSE: Although in trypanosomatids, monoxeny (Leptomonas) is ancestral to dixeny (Leishmania), however clinical cases of visceral leishmanisis with Leptomonas co-infection are increasingly being reported from India. Using a proteogenomic approach, we carried out a detailed proteome analysis of these two kinetoplastid parasites viz. Leishmania and its sister Leptomonas, to catalog the key proteins associated with and therefore possibly responsible for phenotype changes in Leptomonas evolution and domestication as co-infection with Leishmania...
February 22, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29469959/oncogenic-mutations-in-keap1-disturbing-inhibitory-nrf2-keap1-interaction-activation-of-antioxidative-pathway-in-papillary-thyroid-carcinoma
#16
Debora Lucia Seguro Danilovic, Evandro Sobroza de Mello, Eliana Salgado Turri Frazzato, Alda Wakamatsu, Alexander Augusto de Lima Jorge, Ana Oliveira Hoff, Suemi Marui
BACKGROUND: Nuclear factor erythroid 2-like 2 (NFE2L2) encodes Nrf2, transcription factor of antioxidative genes. In the presence of reactive oxygen species, Keap1 (Kelch-ECH-associating protein-1) inhibitor complex undergoes conformational changes disrupting Keap1-Nrf2 binding and Nrf2 translocates into nucleus. We evaluated the presence of mutations in NFE2L2 and KEAP1 in papillary thyroid carcinomas (PTCs) and correlated them with clinical presentation. METHODS: Coding regions of NFE2L2 and KEAP1 were sequenced in 131 patients with PTC...
February 22, 2018: Head & Neck
https://www.readbyqxmd.com/read/29469944/multicentre-randomized-clinical-trial-of-the-effect-of-chewing-gum-after-abdominal-surgery
#17
E M de Leede, N J van Leersum, H M Kroon, V van Weel, J R M van der Sijp, B A Bonsing
BACKGROUND: Postoperative ileus is a common complication of abdominal surgery, leading to patient discomfort, morbidity and prolonged postoperative length of hospital stay (LOS). Previous studies suggested that chewing gum stimulates bowel function after abdominal surgery, but were underpowered to evaluate its effect on LOS and did not include enhanced recovery after surgery (ERAS)-based perioperative care. This study evaluated whether chewing gum after elective abdominal surgery reduces LOS and time to bowel recovery in the setting of ERAS-based perioperative care...
February 22, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29469775/coexistence-of-keloids-and-pilomatricoma-in-a-patient-with-rubinstein-taybi-syndrome
#18
Yosuke Yagi, Yutaka Kuwatsuka, Misachi Asai, Mai Honda, Atsushi Utani
Rubinstein-Taybi syndrome (RTS) is an autosomaldominant hereditary disease, which contains many skeletal and organ anomalies as well as mental retardation. Although high incidence of keloids in RTS is known, it is difficult to find a detailed report on the clinical features of keloids. In the following letter, we report an RTS patient fulfilling diagnostic criteria whosuffered from both keloids and pilomatricoma. We also performed a literature search, which identified the possible involvement of the Wnt/β-catenin signaling pathway in the pathogenesis of these two skin lesions...
January 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469757/delusions-of-parasitosis-a-brief-review-of-the-literature-and-pathway-for-diagnosis-and-treatment
#19
Nicholas Laidler
A large proportion of patients seen in dermatology practices have underlying psychological issues associated with their skin diseases. One of the most flagrant examples of this are patients with delusions of parasitosis. These patients have false fixed beliefs that they are infested by parasites and experience cutaneous sensations of crawling, biting, and stinging associated with their delusions. There is no organic skin disorder and all cutaneous manifestations are self-induced. Rather than a psychiatrist, the dermatologist is often designated by the patient to handle the chief complaint, even though the main disorder is psychogenic...
January 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469197/physiologically-based-pharmacokinetic-modeling-of-a-cyp2c19-substrate-bms-823778-utilizing-pharmacogenetic-data
#20
Jiachang Gong, Lisa Iacono, Ramaswamy A Iyer, W Griffith Humphreys, Ming Zheng
AIMS: Previous studies demonstrated direct correlation between CYP2C19 genotype and BMS-823778 clearance in healthy volunteers. The objective of the present study was to develop a PBPK model for BMS-823778 and utilize the model to predict PK and DDI in virtual populations with multiple polymorphic genes. METHODS: The PBPK model was built and verified utilizing existing clinical data. The verified model was simulated to predict PK of BMS-823778 and significance of DDI with a strong CYP3A4 inhibitor in subjects with various CYP2C19 and UGT1A4 genotypes...
February 22, 2018: British Journal of Clinical Pharmacology
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