keyword
MENU ▼
Read by QxMD icon Read
search

Hepatobiliary diseases

keyword
https://www.readbyqxmd.com/read/29229136/the-gut-liver-axis-impact-of-a-mouse-model-of-small-bowel-bacterial-overgrowth
#1
Qingqing Wang, Bin Wang, Vijay Saxena, Lili Miles, Josh Tiao, Joel E Mortensen, Jaimie D Nathan
BACKGROUND: The mechanisms by which intestinal bacteria impact liver diseases remain poorly understood. The aim of this study was to develop a mouse model of small-bowel bacterial overgrowth and to determine its impact on hepatobiliary injury. MATERIALS AND METHODS: A jejunal self-filling blind loop (SFBL) was created in C57BL/6 mice. Three weeks after surgery, the mice were euthanized, and bacterial cultures of luminal content of the loop and extraintestinal tissues were performed...
January 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29226107/cholangitis-diagnosis-treatment-and-prognosis
#2
REVIEW
Amir Houshang Mohammad Alizadeh
Cholangitis is a serious life-threatening situation affecting the hepatobiliary system. This review provides an update regarding the clinical and pathological features of various forms of cholangitis. A comprehensive search was performed in the PubMed, Scopus, and Web of Knowledge databases. It was found that the etiology and pathogenesis of cholangitis are heterogeneous. Cholangitis can be categorized as primary sclerosing (PSC), secondary (acute) cholangitis, and a recently characterized form, known as IgG4-associated cholangitis (IAC)...
December 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/29212771/establishment-of-a-surgical-bile-duct-injection-technique-giving-direct-access-to-the-bile-ducts-for-studies-of-the-murine-biliary-tree
#3
Natalie Lie Berntsen, Bjarte Fosby, Laura Valestrand, Corey Tan, Henrik Reims, Elisabeth Schrumpf, Tom H Karlsen, Pål-Dag Line, Espen Melum
Cholangiopathies are progressive disorders with largely unknown pathoetiology and limited treatment options. We aimed to develop a novel surgical technique with direct access to the bile ducts that would complement existing mouse models of cholestasis, biliary inflammation and fibrosis, and present a new route of administration for testing of potential treatment strategies. We developed a surgical technique to access the murine biliary tree by injection of different solvents through catheterization of the gall bladder with simultaneous clamping of the common bile duct...
December 6, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29210091/clinical-relevance-of-radiographic-linear-branching-mineral-opacities-in-the-canine-liver
#4
M-A Genain, A Barbosa, M Herrtage, P Watson
OBJECTIVES: To assess the prevalence, clinical significance and breed distribution of linear branching mineralisation superimposed on the hepatic radiographic silhouette in dogs. MATERIALS AND METHODS: Retrospective review of radiographs or ultrasound images of dogs showing branching mineralisation in the liver. RESULTS: Over the 30-year review period, 17 cases were identified and the mineralisation had a predominantly ventral distribution...
December 6, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29207969/pre-treatment-alphafeto-protein-in-hepatocellular-carcinoma-with-non-viral-aetiology-a-prospective-study
#5
Siriwardana Rohan Chaminda, Thilakarathne Suchintha, Niriella Madunil Anuk, Dassanayake Anuradha Supun, Gunathilake Mahen Bhagya, Liyanage Chandika Anuruddha Habarakada, De Silva Hithadurage Janaka
BACKGROUND: Alpha-fetoprotein (AFP) is a biomarker for hepatocellular carcinoma (HCC). The significance of pre-treatment AFP (pt-AFP) in non-viral HCC (nvHCC) is not clear. METHODS: Patients with nvHCC, referred to a Hepatobiliary Clinic from September 2011-2015 were screened. HCC was diagnosed using American Association for the Study of Liver Disease guidelines, and TNM staged. nvHCC was diagnosed when HBsAg and anti-HCVAb was negative. Child-Turcotte-Pugh (CTP) and Model for End-stage Liver Disease (MELD) scores were calculated...
December 6, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29206676/hepatobiliary-hands-of-hopkins
#6
Henry A Pitt
OBJECTIVE: This historical perspective documents the role that John L. Cameron played in advancing hepatobiliary research, education, and surgery at Johns Hopkins in the 1970s, 1980s, and 1990s. SUMMARY OF BACKGROUND DATA: Dating back to William S. Halsted in the 19th century, leaders of the Department of Surgery at Johns Hopkins have been interested in hepatobiliary disease and surgery. John L. Cameron had broad hepato-pancreato-biliary (HPB) interests when he completed his surgical training...
December 4, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29205351/oncologic-effects-of-preoperative-biliary-drainage-in-resectable-hilar-cholangiocarcinoma-percutaneous-biliary-drainage-has-no-adverse-effects-on-survival
#7
Xu-Feng Zhang, Eliza W Beal, Katiuscha Merath, Cecilia G Ethun, Ahmed Salem, Sharon M Weber, Thuy Tran, George Poultsides, Andre Y Son, Ioannis Hatzaras, Linda Jin, Ryan C Fields, Matthew Weiss, Charles Scoggins, Robert C G Martin, Chelsea A Isom, Kamron Idrees, Harveshp D Mogal, Perry Shen, Shishir K Maithel, Carl R Schmidt, Timothy M Pawlik
BACKGROUND AND OBJECTIVES: The objective of the current study was to define long-term survival of patients with resectable hilar cholangiocarcinoma (HCCA) after preoperative percutaneous transhepatic biliary drainage (PTBD) versus endoscopic biliary drainage (EBD). METHODS: Between 2000 and 2014, 240 patients who underwent curative-intent resection for HCCA were identified at 10 major hepatobiliary centers. Postoperative morbidity and mortality, as well as disease-specific survival (DSS) and recurrence-free survival (RFS) were analyzed among patients...
December 4, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29203284/intermediate-term-survival-and-quality-of-life-outcomes-in-patients-with-advanced-colorectal-liver-metastases-undergoing-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy
#8
Kerollos Nashat Wanis, Victoria Ardiles, Fernando A Alvarez, Mauro Enrique Tun-Abraham, David Linehan, Eduardo de Santibañes, Roberto Hernandez-Alejandro
BACKGROUND: Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is an innovative, 2-staged hepatectomy which has elicited controversy within the international hepatobiliary community. Uptake of ALPPS has been limited due to concerns related to evidence of high morbidity and mortality and scant oncologic and quality of life outcome data and quality of life (Ool). Demonstrating reasonable long-term benefits with a short-term risk is necessary to support more widespread endorsement of ALPPS...
December 1, 2017: Surgery
https://www.readbyqxmd.com/read/29201802/hepatic-metastasis-from-colorectal-cancer
#9
Alan I Valderrama-Treviño, Baltazar Barrera-Mera, Jesús C Ceballos-Villalva, Eduardo E Montalvo-Javé
The liver is the most common site of metastasis in patients with colorectal cancer due to its anatomical situation regarding its portal circulation. About 14 to 18% of patients with colorectal cancer present metastasis at the first medical consultation, and 10 to 25% at the time of the resection of the primary colorectal cancer. The incidence is higher (35%) when a computed tomography (CT) scan is used. In the last decades, a significant increase in the life expectancy of patients with colorectal cancer has been achieved with different diagnostic and treatment programs...
July 2017: Euroasian Journal of Hepato-Gastroenterology
https://www.readbyqxmd.com/read/29194011/rapid-source-control-laparotomy-is-there-a-mortality-benefit-in-septic-shock
#10
James Vogler, Leslie Hart, Sharon Holmes, Jason Sciaretta, John Mihran Davis
BACKGROUND: In the 1990s, damage control laparotomy (DCL) became a proved approach to treat intra-abdominal injuries caused by trauma. In the ensuing two decades, this approach has been applied to non-traumatic abdominal processes as well. Although the benefits of DCL are clear, the benefit of rapid source-control laparotomy (RSCL) for non-traumatic abdominal diseases is much less clear. However, two recent cohort analyses identified significant increases in the mortality rate with RCSL compared with primary fascial closure (PFC)...
December 1, 2017: Surgical Infections
https://www.readbyqxmd.com/read/29193901/hepatitis-c-virus-infection-and-risk-of-gallstones-a-meta-analysis
#11
Karn Wijarnpreecha, Charat Thongprayoon, Panadeekarn Panjawatanan, Natasorn Lekuthai, Patompong Ungprasert
BACKGROUND/OBJECTIVES: Gallstones and its complications are one of the most common hepatobiliary tract diseases. Several epidemiologic studies have suggested that patients with hepatitis C virus (HCV) infection might be at an increased risk of gallstones. However, the data on this relationship remain inconclusive. This meta-analysis was conducted with the aims to summarize all available evidence. METHODS: A literature search was performed using MEDLINE and EMBASE databases from inception to May 2016...
November 2017: Journal of Evidence-based Medicine
https://www.readbyqxmd.com/read/29184185/cellular-senescence-in-gastrointestinal-diseases-from-pathogenesis-to-therapeutics
#12
REVIEW
Nina Frey, Sascha Venturelli, Lars Zender, Michael Bitzer
Senescence is a durable cell cycle arrest that can be induced in response to various stress factors, such as telomere erosion, DNA damage or the aberrant activation of oncogenes. In addition to its well-established role as a stress response programme, research has revealed important physiological roles of senescence in nondisease settings, such as embryonic development, wound healing, tissue repair and ageing. Senescent cells secrete various cytokines, chemokines, matrix remodelling proteases and growth factors, a phenotype collectively referred to as the senescence-associated secretory phenotype...
November 29, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29172644/combined-thoracic-and-hepatobiliary-surgery-for-iatrogenic-bronchobiliary-fistula
#13
Marion Mauduit, Simon Rouze, Kathleen Turner, Bertrand de Latour, Jean-Philippe Verhoye
Bronchobiliary fistula is a rare pathology mainly caused by hepatic tumors, bile duct obstruction, or hepatic hydatid disease. A 70-year-old man developed a bronchobiliary fistula after biliary stenting. After failure of conservative treatment including endoscopic retrograde biliary drainage, he underwent a combined operation with a two-level approach. Both a thoracotomy and laparotomy were performed, allowing pulmonary resection, diaphragmatic repair, and bile duct reconstruction during the same operation...
January 1, 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/29158186/diffusion-kurtosis-imaging-with-the-breath-hold-technique-for-staging-hepatic-fibrosis-a-preliminary-study
#14
Daisuke Yoshimaru, Toshiaki Miyati, Yuichi Suzuki, Yuhki Hamada, Nozomi Mogi, Ayumu Funaki, Ayumi Tabata, Atsuko Masunaga, Masahiko Shimada, Maki Tobari, Takayoshi Nishino
PURPOSE: To evaluate the potential of diffusion kurtosis imaging (DKI) analysis with the breath-hold technique to assess the stage or classify hepatic fibrosis. MATERIALS AND METHODS: Patients (n=67) suspected of having a disease of the hepatobiliary system examined by diffusion-weighted imaging (DWI) using a 3.0-T magnetic resonance imaging unit were enrolled in this study. To evaluate hepatic fibrosis, mean kurtosis, Mean apparent diffusion (MD) and apparent diffusion coefficient (ADC) values were compared between groups with varying fibrosis; F0-F1, F2-F3, and F4...
November 17, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29150719/preoperative-optimization-for-major-hepatic-resection
#15
REVIEW
Sarah Walcott-Sapp, Kevin G Billingsley
PURPOSE: Major hepatic resections are performed for primary hepatobiliary malignancies, metastatic disease, and benign lesions. Patients with chronic liver disease, including cirrhosis and steatosis, are at an elevated risk of malnutrition and impaired strength and exercise capacity, deficits which cause increased risk of postoperative complications and mortality. The aims of this report are to discuss the pathophysiology of changes in nutrition, exercise capacity, and muscle strength in patient populations likely to require major hepatectomy, and review recommendations for preoperative evaluation and optimization...
November 18, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/29135498/state-of-the-john-l-cameron-md-division-of-hepatobiliary-and-pancreatic-surgery-the-program-that-john-cameron-built
#16
Ammar A Javed, Christopher L Wolfgang
: The pancreatic surgery program at Johns Hopkins is recognized as being among the top programs in the field. It is part of the newly formed John L. Cameron Division of HPB surgery. This division of surgery is a highly productive group of academic surgeons in terms of clinical volume, research endeavors, and education. The division functions as part of a large multidisciplinary group at Johns Hopkins. The program has an interesting history and can trace its roots back to the actions of a single individual-John L...
November 13, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29131399/cholangitis-and-cholangiohepatitis-in-dogs-a-descriptive-study-of-54-cases-based-on-histopathologic-diagnosis-2004-2014
#17
J L Harrison, B J Turek, D C Brown, C Bradley, J Callahan Clark
BACKGROUND: Cholangitis in dogs appears to be more common than previously thought, but understanding of the disease remains incomplete. OBJECTIVE: To describe a population of dogs with cholangitis or cholangiohepatitis. ANIMALS: Fifty-four client-owned dogs with cholangitis or cholangiohepatitis. METHODS: Medical records of dogs with cholangitis or cholangiohepatitis confirmed by histopathology between January 2004 and December 2014 were identified using a computer-based search and retrospectively reviewed...
November 13, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29131323/validity-and-usefulness-of-a-single-item-measure-of-patient-reported-bother-from-side-effects-of-cancer-therapy
#18
Timothy P Pearman, Jennifer L Beaumont, Daniel Mroczek, Mary O'Connor, David Cella
BACKGROUND: The improving efficacy of cancer treatment has resulted in an increasing array of treatment-related symptoms and associated burdens imposed on individuals undergoing aggressive treatment of their disease. Often, clinical trials compare therapies that have different types, and severities, of adverse effects. Whether rated by clinicians or patients themselves, it can be difficult to know which side effect profile is more disruptive or bothersome to patients. A simple summary index of bother can help to adjudicate the variability in adverse effects across treatments being compared with each other...
November 13, 2017: Cancer
https://www.readbyqxmd.com/read/29129603/a-rapid-quantitative-analysis-of-bile-acids-lysophosphatidylcholines-and-polyunsaturated-fatty-acids-in-biofluids-based-on-ultraperformance-liquid-chromatography-coupled-with-triple-quadrupole-tandem-massspectrometry
#19
Zhangxiao Peng, Qian Zhang, Ziming Mao, Jie Wang, Chunying Liu, Xuejing Lin, Xin Li, Weidan Ji, Jianhui Fan, Maorong Wang, Changqing Su
Much evidence suggested that quantitative analysis of bile acids (BAs), lysophosphatidylcholines (LPCs), and polyunsaturated fatty acids (PUFAs) in biofluids may be very useful for diagnosis and prevention of hepatobiliary disease with a non-invasive manner. However, simultaneously fast analysis of these metabolites has been challenging for their huge differences of physicochemical properties and concentration levels in biofluids. In this study, we present a liquid chromatography-mass spectrometry method with a high throughput analytical cycle (10min) to fast and accurately quantify fifteen potential biomarkers (eight BAs, four LPCs and three PUFAs) of hepatobiliary disease...
November 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29127962/minimally-invasive-hepatobiliary-surgery
#20
REVIEW
Omid Madadi-Sanjani, Claus Petersen, Benno Ure
Comparative studies and large-scale case series that confirm the advantages of laparoscopy in children with hepatobiliary diseases are scarce, and the use of laparoscopy remains a matter of debate. This article reviews the current literature on the role of laparoscopic and robotic surgery in pediatric patients with choledochal cyst, biliary atresia, gallbladder diseases, and hepatobiliary malignancies. Studies were identified through a search of the MEDLINE database. Laparoscopy may be beneficial for resection of choledochal cyst and cholecystectomy...
December 2017: Clinics in Perinatology
keyword
keyword
101934
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"