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Liquid Handling

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https://www.readbyqxmd.com/read/28528850/overview-of-solidification-techniques-for-self-emulsifying-drug-delivery-systems-from-industrial-perspective
#1
J Mandić, A Zvonar Pobirk, F Vrečer, M Gašperlin
Self-emulsifying drug delivery systems (SEDDS) are lipid formulations that improve solubility and oral bioavailability of the incorporated drug with poor biopharmaceutical properties. As liquids they are traditionally filled into soft or hard capsules. Transformation of SEDDS into solid dosage form has been extensively investigated in the recent years because solid dosage forms improve stability, handling and patient compliance. By using different solidification techniques selfemulsifying powders, granules, pellets and tablets can be produced...
May 18, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28520436/controlling-structure-and-function-of-polymeric-drug-delivery-nanoparticles-using-microfluidics
#2
Aman Bains, Yimeng Cao, Sundiata Kly, Jeremy E Wulff, Matthew G Moffitt
We demonstrate control of multiscale structure and drug delivery function for paclitaxel (PAX)-loaded polycaprolactone-block-poly(ethylene oxide) (PCL-b-PEO) polymeric nanoparticles (PNPs) via synthesis and flow-directed shear processing in a two-phase gas-liquid microfluidic reactor. This strategy takes a page from the engineering of commodity plastics, where processing rather than polymer chemistry provides an experimental handle on properties and function. PNPs formed from copolymers with three different PCL block lengths show sizes, morphologies, and loading efficiencies that depend on both the PCL block length and the microfluidic flow rate...
May 18, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28512029/calixarene-mediated-liquid-membrane-transport-of-choline-conjugates-3-the-effect-of-handle-variation-on-neurotransmitter-transport
#3
James L Collins, Ayu Fujii, Sahar Roshandel, Cuong-Alexander To, Michael P Schramm
Upper rim phosphonic acid functionalized calix[4]arene affects selective transport of multiple molecular payloads through a liquid membrane. The secret is in the attachment of a receptor-complementary handle to the payload. We find that the trimethylammonium ethylene group present in choline is one of several general handles for the transport of drug and drug-like species. Herein we compare the effect of handle variation against the transport of serotonin and dopamine. We find that several ionizable amine termini handles are sufficient for transport and identify two ideal candidates...
May 5, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28505067/risk-assessment-of-florists-exposed-to-pesticide-residues-through-handling-of-flowers-and-preparing-bouquets
#4
Khaoula Toumi, Laure Joly, Christiane Vleminckx, Bruno Schiffers
Flowers are frequently treated with pesticides and, as a result, florists handling daily a large number of flowers can be exposed to pesticide residues. A study was conducted among twenty volunteer florists located in Namur Province and in the Brussels Capital Region of Belgium in order to assess their potential dermal exposure to dislodgeable pesticide residues transferred from flowers to hands. Two pairs of cotton gloves were worn during two consecutive half days while handling flowers and preparing bouquets (from min 2 h to max 3 h/day)...
May 13, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28499879/developing-a-flexible-pediatric-dosage-form-for-antiretroviral-therapy-a-fast-dissolving-tablet
#5
Manjari Lal, Manshun Lai, Marcus Estrada, Changcheng Zhu
Current presentations of the anti-HIV drugs lopinavir and ritonavir make appropriate dosing for children difficult. We conducted a feasibility study to develop a formulation for these drugs with child-safe excipients in a flexible dosage form for children across the pediatric age spectrum. The freeze-drying-in-blister approach was used to produce fast-dissolving tablets (FDTs), as these can be dispersed in fluids for easy administration, even to infants, and appropriate portions of the dispersion can be given for different ages/weights...
May 9, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28498336/-11-c-labeling-of-aryl-ketones-as-candidate-histamine-subtype-3-receptor-pet-radioligands-through-pd-0-mediated-11-c-carbonylative-coupling
#6
Fabrice G Siméon, William J Culligan, Shuiyu Lu, Victor W Pike
Pd(0)-mediated coupling between iodoarenes, [(11)C]carbon monoxide and aryltributylstannanes has been used to prepare simple model [(11)C]aryl ketones. Here, we aimed to label four 2-aminoethylbenzofuran chemotype based molecules ([(11)C]1-4) in the carbonyl position, as prospective positron emission tomography (PET) radioligands for the histamine subtype 3 receptor (H3R) by adapting this methodology with use of aryltrimethylstannanes. Radiosynthesis was successfully performed on a platform equipped with a mini-autoclave and a liquid handling robotic arm, within a lead-shielded hot-cell...
May 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28490925/management-of-egfr-mutated-non-small-cell-lung-cancer-practical-implications-from-a-clinical-and-pathology-perspective
#7
REVIEW
M Cabanero, R Sangha, B S Sheffield, M Sukhai, M Pakkal, S Kamel-Reid, A Karsan, D Ionescu, R A Juergens, C Butts, M S Tsao
Starting in the early 2000s, non-small-cell lung cancer (nsclc) subtypes have evolved from being histologically described to molecularly defined. Management of lung adenocarcinomas now generally requires multiple molecular tests at baseline to define the optimal treatment strategy. More recently, second biopsies performed at progression in patients treated with tyrosine kinase inhibitors (tkis) have further defined the continued use of molecularly targeted therapy. In the present article, we focus on one molecular subtype: EGFR-mutated nsclc...
April 2017: Current Oncology
https://www.readbyqxmd.com/read/28490046/rapid-homogeneous-immunoassay-to-quantify-gemcitabine-in-plasma-for-therapeutic-drug-monitoring
#8
Daniel Kozo, Matt W Ross, Justin Jarrah, Michael Barrett, Rebecca L Harney, Jodi B Courtney, Irina Baburina, Julianne L Holleran, Jan H Beumer, Godefridus J Peters, Richard J Honeywell, Salvatore J Salamone
BACKGROUND: Gemcitabine (2',2'-difluoro-2'-deoxycytidine) is a nucleoside analog used as a single agent and in combination regimens for the treatment of a variety of solid tumors. Several studies have shown a relationship between gemcitabine peak plasma concentration (Cmax) and hematological toxicity. An immunoassay for gemcitabine in plasma was developed and validated to facilitate therapeutic drug monitoring (TDM) by providing an economical, robust method for automated chemistry analyzers...
June 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28479369/genomic-profiling-of-advanced-non-small-cell-lung-cancer-in-community-settings-gaps-and-opportunities
#9
Martin E Gutierrez, Kelly Choi, Richard B Lanman, Edward J Licitra, Stanley M Skrzypczak, Ruth Pe Benito, Tommy Wu, Srikesh Arunajadai, Sukhi Kaur, Harry Harper, Andrew L Pecora, Eric V Schultz, Stuart L Goldberg
BACKGROUND: National guidelines have advocated broad molecular profiling as a part of the standard diagnostic evaluation for advanced non-small cell lung cancer (NSCLC), with the goal of identifying driver mutations for which effective therapies or clinical trials are available. However, adherence to genomic testing guidelines could present challenges to community oncologists. PATIENTS AND METHODS: We performed a retrospective review of genomic testing patterns in patients with nonsquamous NSCLC treated by 89 oncologists at 15 sites throughout New Jersey and Maryland from January 2013 to December 2015...
April 13, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28471642/paper-microzone-plates-as-analytical-tools-for-studying-enzyme-stability-a-case-study-on-the-stabilization-of-horseradish-peroxidase-using-trehalose-and-su-8-epoxy-novolac-resin
#10
Kirsten A Ganaja, Cory A Chaplan, Jingyi Zhang, Nathaniel W Martinez, Andres W Martinez
Paper microzone plates in combination with a noncontact liquid handling robot were demonstrated as tools for studying the stability of enzymes stored on paper. The effect of trehalose and SU-8 epoxy novolac resin (SU-8) on the stability of horseradish peroxidase (HRP) was studied in both a short-term experiment, where the activity of various concentrations of HRP dried on paper were measured after 1 h, and a long-term experiment, where the activity of a single concentration of HRP dried and stored on paper was monitored for 61 days...
May 4, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28468895/vitamin-b-6-deficiency-is-common-and-associated-with-poor-long-term-outcome-in-renal-transplant-recipients
#11
Isidor Minović, Ineke J Riphagen, Else van den Berg, Jenny E Kootstra-Ros, Martijn van Faassen, Antonio W Gomes Neto, Johanna M Geleijnse, Reinold Ob Gans, Manfred Eggersdorfer, Gerjan J Navis, Ido P Kema, Stephan Jl Bakker
Background: Previous studies have reported low circulating concentrations of pyridoxal-5-phospate (PLP) in renal transplant recipients (RTRs). It is unknown whether this is because of low intake or altered handling, and it is also unknown whether variation in circulating concentrations of PLP influences long-term outcome.Objective: We compared vitamin B-6 intake and circulating PLP concentrations of RTRs with those of healthy controls and investigated long-term clinical implications of vitamin B-6 deficiency in stable outpatient RTRs...
May 3, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28464345/ion-tagged-oligonucleotides-coupled-with-a-magnetic-liquid-support-for-the-sequence-specific-capture-of-dna
#12
Kevin D Clark, Marcelino Varona, Jared Anderson
The isolation of specific nucleic acid sequences is a major bottleneck in molecular diagnostics. Magnetic beads/particles are typically used as solid supports for the capture of DNA targets to improve sample throughput, but aggregate over time resulting in lower capture efficiency and obstruction of liquid handling devices. Here, we describe a particle-free approach to sequence-specific DNA extraction using a magnetic liquid support and ion-tagged oligonucleotide (ITO) probes. ITO conjugates were synthesized with the highest yields ever achieved for the radical thiol-ene coupling of a substrate and oligonucleotide...
May 2, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28463480/an-open-pit-nanofluidic-tool-localized-chemistry-assisted-by-mesoporous-thin-film-infiltration
#13
Magalí Mercuri, Karina A Pierpauli, Claudio L A Berli, Martín G Bellino
Nanofluidics based on nanoscopic porous structures has emerged as the next evolutionary milestone in the construction of versatile nanodevices with unprecedented applications. However, the straightforward development of nanofluidically interconnected systems is crucial for the production of practical devices. Here, we demonstrate that spontaneous infiltration into supramolecularly templated mesoporous oxide films at the edge of a sessile drop in open air can be used to connect pairs of landmarks. The liquids from the drops can then join through the nanoporous network to guide a localized chemical reaction at the nanofluid-front interface...
May 5, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28439749/slippage-a-significant-problem-following-gastric-banding-a-single-centre-experience
#14
Tomasz Szewczyk, Przemyslaw Janczak, Natalia Jezierska, Piotr Jurałowicz
BACKGROUND: Laparoscopic adjustable gastric banding is a well-established method of morbid obesity treatment. One of the complications is slippage. AIM: The aim of the study was to assess the prevalence, causes, and handling of slippage after LAGB in own material. MATERIAL AND METHODS: There were 740 procedures performed by one surgical team. The patients were selected according to the IFSO principles. The pars flaccida technique was applied and the position of the band was controlled...
April 24, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28437771/solvent-bar-micro-extraction-sbme-based-determination-of-pahs-in-seawater-samples
#15
José A López-López, Esther Ogalla-Chozas, Pablo A Lara-Martín, Marina G Pintado-Herrera
Measuring the impact of PAHs in seawater samples is often difficult due to the low concentrations in which they appear and the complexity of the sample matrix. Traditional methods for sample preparation such as liquid-liquid extraction and solid phase extraction require the use of excessive amounts of solvents and reagents, and sample handling. In this work, hollow fiber liquid phase micro-extraction (HFLPME), in the configuration of solvent bar micro-extraction (SBME), was proposed as an environmentally friendly and more effective tool, for the extraction of the 16 priority PAHs from seawater samples...
April 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28433720/establishment-of-a-non-invasive-method-for-stress-evaluation-in-farmed-salmon-based-on-direct-fecal-corticoid-metabolites-measurement
#16
Yanran Cao, Ann-Kristin Tveten, Anne Stene
Fish welfare is an important issue for growth of the aquaculture industry. Stress responses represent animal's natural reactions to challenging conditions and could be used as a welfare indicator. Cortisol level is relevant to fish welfare condition, and is a readily measured component of the primary stress response system. Generally, cortisol is measured by blood sampling. However, fish blood cortisol level could be instantly influenced by handling-stress at sampling. Fecal corticoid metabolites (FCM) are a mixture of several different metabolites with a wide range of polarities...
April 19, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28433611/preanalytical-variables-for-liquid-chromatography-mass-spectrometry-lc-ms-analysis-of-human-blood-specimens
#17
REVIEW
Gian Luca Salvagno, Elisa Danese, Giuseppe Lippi
The use of liquid chromatography-mass spectrometry (LC-MS) for both diagnostics and research purposes is rapidly growing in clinical laboratories. As for more conventional areas of in vitro diagnostic testing, many preanalytical variables have an impact on these techniques and may hence jeopardize the quality of tests results. The leading preanalytical variables include patient preparation, the nature of the blood collection tubes and additives, interference from spurious hemolysis, sample handling and management, composition of blood tubes, contamination, as well as storage conditions...
April 19, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28426080/c-reactive-protein-and-interleukin-6-microfluidic-immunoassays-with-on-chip-pre-stored-reagents-and-centrifugo-pneumatic-liquid-control
#18
Y Zhao, G Czilwik, V Klein, K Mitsakakis, R Zengerle, N Paust
We present a fully automated centrifugal microfluidic method for particle based protein immunoassays. Stick-pack technology is employed for pre-storage and release of liquid reagents. Quantitative layout of centrifugo-pneumatic particle handling, including timed valving, switching and pumping is assisted by network simulations. The automation is exclusively controlled by the spinning frequency and does not require any additional means. New centrifugal microfluidic process chains are developed in order to sequentially supply wash buffer based on frequency dependent stick-pack opening and pneumatic pumping to perform two washing steps from one stored wash buffer; pre-store and re-suspend functionalized microparticles on a disk; and switch between the path of the waste fluid and the path of the substrate reaction product with 100% efficiency...
May 2, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28418274/the-gulf-long-term-follow-up-study-gulf-study-biospecimen-collection-at-enrollment
#19
Lawrence S Engel, Richard K Kwok, Aubrey K Miller, Aaron Blair, Matthew D Curry, John A McGrath, Dale P Sandler
The 2010 Deepwater Horizon (DWH) explosion in the Gulf of Mexico led to the largest ever marine oil spill by volume. The GuLF STUDY is investigating possible adverse human health effects associated with oil spill activities. One objective of the study was to utilize biological specimens from study participants to examine spill-related adverse health effects. This study describes the methods for collecting, processing, shipping, and storing specimens during the enrollment phase of the study. GuLF STUDY participants living in Gulf States (Alabama, Florida, Louisiana, Mississippi, and eastern Texas) were eligible to complete a home visit at enrollment, one to three years after the DWH explosion...
April 18, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28417536/stretchable-and-soft-electronics-using-liquid-metals
#20
REVIEW
Michael D Dickey
The use of liquid metals based on gallium for soft and stretchable electronics is discussed. This emerging class of electronics is motivated, in part, by the new opportunities that arise from devices that have mechanical properties similar to those encountered in the human experience, such as skin, tissue, textiles, and clothing. These types of electronics (e.g., wearable or implantable electronics, sensors for soft robotics, e-skin) must operate during deformation. Liquid metals are compelling materials for these applications because, in principle, they are infinitely deformable while retaining metallic conductivity...
April 18, 2017: Advanced Materials
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