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https://www.readbyqxmd.com/read/29346644/genome-wide-analysis-of-disease-progression-in-age-related-macular-degeneration
#1
Qi Yan, Ying Ding, Yi Liu, Tao Sun, Lars G Fritsche, Traci Clemons, Rinki Ratnapriya, Michael L Klein, Richard J Cook, Yu Liu, Ruzong Fan, Lai Wei, Gonçalo R Abecasis, Anand Swaroop, Emily Y Chew, Daniel E Weeks, Wei Chen
Family- and population-based genetic studies have successfully identified multiple disease-susceptibility loci for Age-related Macular Degeneration (AMD), one of the first batch and most successful examples of genome-wide association study (GWAS). However, most genetic studies to date have focused on case-control studies of late AMD (choroidal neovascularization [CNV] or geographic atrophy [GA]). The genetic influences on disease progression are largely unexplored. We assembled unique resources to perform a genome-wide bivariate time-to-event analysis to test for association of time-to-late-AMD with ∼9 million variants on 2,721 Caucasians from a large multi-center randomized clinical trial, the Age-Related Eye Disease Study...
January 15, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29346606/characteristics-of-cases-with-repeated-sexually-transmitted-infections-massachusetts-2014-2016
#2
Katherine K Hsu, Lauren E Molotnikov, Kathleen A Roosevelt, Heather R Elder, R Monina Klevens, Alfred DeMaria, Sevgi O Aral
Background: Persons with prior sexually transmitted infections (STIs) are at high risk for re-infection. No recent studies have examined the frequency with which persons within a geographic area are diagnosed and reported with multiple bacterial STIs over time. Methods: We conducted a retrospective, population-based study of confirmed syphilis, gonorrhea, and chlamydial infections reported to the Massachusetts state surveillance system within a two-year period, July 28, 2014 - July 27, 2016...
January 13, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29346526/what-is-the-impact-of-physical-activity-and-physical-function-on-the-development-of-multimorbidity-in-older-adults-over-time-a-population-based-cohort-study
#3
Aine Ryan, Catriona Murphy, Fiona Boland, Rose Galvin, Susan M Smith
Background: Multimorbidity is recognised internationally as having a serious impact on health outcomes. It is associated with reduced quality of life, increased healthcare utilisation and future functional decline. Physical activity is associated with good health and psychological well-being. The aim of this study was to identify the impact of physical activity and physical function on the development and worsening of multimorbidity over time. Methods: Using The Irish Longitudinal Study on Ageing (TILDA), we analysed 4,823 participants >50 years with and without multimorbidity...
January 13, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29346471/use-of-single-nucleotide-polymorphisms-and-mammographic-density-plus-classic-risk-factors-for-breast-cancer-risk-prediction
#4
Elke M van Veen, Adam R Brentnall, Helen Byers, Elaine F Harkness, Susan M Astley, Sarah Sampson, Anthony Howell, William G Newman, Jack Cuzick, D Gareth R Evans
Importance: Single-nucleotide polymorphisms (SNPs) have demonstrated an association with breast cancer susceptibility, but there is limited evidence on how to incorporate them into current breast cancer risk prediction models. Objective: To determine whether a panel of 18 SNPs (SNP18) may be used to predict breast cancer in combination with classic risk factors and mammographic density. Design, Setting, and Participants: This cohort study enrolled a subcohort of 9363 women, aged 46 to 73 years, without a previous breast cancer diagnosis from the larger prospective cohort of the PROCAS study (Predicting Risk of Cancer at Screening) specifically to evaluate breast cancer risk-assessment methods...
January 18, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29346467/modification-of-the-associations-between-duration-of-oral-contraceptive-use-and-ovarian-endometrial-breast-and-colorectal-cancers
#5
Kara A Michels, Ruth M Pfeiffer, Louise A Brinton, Britton Trabert
Importance: Although oral contraceptive (OC) use is common, the influence of OC use on carcinogenesis is not fully understood. A recent Agency for Healthcare Research and Quality report identified a need to understand the consistency of OC use and cancer associations across subpopulations, including smokers and obese women. Objective: To determine whether associations between duration of OC use and risk of specific cancers were modified by lifestyle characteristics...
January 18, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29346391/development-and-validation-of-a-population-based-risk-algorithm-for-obesity-the-obesity-population-risk-tool-oport
#6
Michael Lebenbaum, Osvaldo Espin-Garcia, Yi Li, Laura C Rosella
BACKGROUND: Given the dramatic rise in the prevalence of obesity, greater focus on prevention is necessary. We sought to develop and validate a population risk tool for obesity to inform prevention efforts. METHODS: We developed the Obesity Population Risk Tool (OPoRT) using the longitudinal National Population Health Survey and sex-specific Generalized Estimating Equations to predict the 10-year risk of obesity among adults 18 and older. The model was validated using a bootstrap approach accounting for the survey design...
2018: PloS One
https://www.readbyqxmd.com/read/29346340/disparities-in-preconception-health-indicators-%C3%A2-behavioral-risk-factor-surveillance-system-2013-2015-and-pregnancy-risk-assessment-monitoring-system-2013-2014
#7
Cheryl Robbins, Sheree L Boulet, Isabel Morgan, Denise V D'Angelo, Lauren B Zapata, Brian Morrow, Andrea Sharma, Charlan D Kroelinger
PROBLEM/CONDITION: Preconception health is a broad term that encompasses the overall health of nonpregnant women during their reproductive years (defined here as aged 18-44 years). Improvement of both birth outcomes and the woman's health occurs when preconception health is optimized. Improving preconception health before and between pregnancies is critical for reducing maternal and infant mortality and pregnancy-related complications. The National Preconception Health and Health Care Initiative's Surveillance and Research work group suggests ten prioritized indicators that states can use to monitor programs or activities for improving the preconception health status of women of reproductive age...
January 19, 2018: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/29346338/current-cigarette-smoking-among-adults-united-states-2016
#8
Ahmed Jamal, Elyse Phillips, Andrea S Gentzke, David M Homa, Stephen D Babb, Brian A King, Linda J Neff
The U.S. Surgeon General has concluded that the burden of death and disease from tobacco use in the United States is overwhelmingly caused by cigarettes and other combusted tobacco products (1). Cigarettes are the most commonly used tobacco product among U.S. adults, and about 480,000 U.S. deaths per year are caused by cigarette smoking and secondhand smoke exposure (1). To assess progress toward the Healthy People 2020 target of reducing the proportion of U.S. adults aged ≥18 years who smoke cigarettes to ≤12...
January 19, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29346068/prevalence-of-hypertension-and-prehypertension-among-a-coastal-population-in-south-india-baseline-findings-from-a-population-based-health-registry-project-in-kerala
#9
T N Anand, M Shaffi, M Pillai A, A Lathika Rajendrakumar, L S Sreemathy, K Rajasekharan Nayar, J Lordson, M Abraham, P Rajeev, A Marthanda Pillai, A Kumar, C Grace A, J Jacob
No abstract text is available yet for this article.
January 12, 2018: Public Health
https://www.readbyqxmd.com/read/29345858/cardiopulmonary-fitness-is-strongly-associated-with-body-cell-mass-and-fat-free-mass
#10
Armin Köhler, Ryan King, Martin Bahls, Stefan Groß, Antje Steveling, Simone Gärtner, Sabine Schipf, Sven Gläser, Henry Völzke, Stephan B Felix, Marcello Ricardo Paulista Markus, Marcus Dörr
BACKGROUND: Peak oxygen uptake (VO2peak) is commonly indexed by total body weight (TBW) to determine cardiopulmonary fitness (CPF). This approach may lead to misinterpretation, particularly in obese subjects. We investigated the normalization of VO2peak by different body composition markers. METHODS: We analyzed combined data of 3,848 subjects (1,914 women; 49.7%), aged 20-90, from two independent cohorts of the population-based Study of Health in Pomerania (SHIP-2 and SHIP-TREND)...
January 18, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29345732/near-visual-impairment-incidence-in-relation-to-diabetes-in-older-people-the-three-cities-study
#11
Marie Danet-Lamasou, Karine Pérès, Fanny Matharan, Claudine Berr, Isabelle Carrière, Christophe Tzourio, Cécile Delcourt, Isabelle Bourdel-Marchasson
OBJECTIVES: To characterize the relationship between diabetes mellitus (DM) and future risk of near vision impairment (VI) in a community-dwelling population of older people. DESIGN: Seven-year population-based longitudinal study. SETTING: Three-Cities Study, a French prospective study designed to assess the risk of cognitive and functional decline attributable to vascular factors. PARTICIPANTS: Community-dwelling individuals aged 65 and older (N = 8,412)...
January 18, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29345608/food-choices-to-meet-nutrient-recommendations-for-the-adult-brazilian-population-based-on-the-linear-programming-approach
#12
Quenia Dos Santos, Rosely Sichieri, Nicole Darmon, Matthieu Maillot, Eliseu Verly-Junior
OBJECTIVE: To identify optimal food choices that meet nutritional recommendations to reduce prevalence of inadequate nutrient intakes. DESIGN: Linear programming was used to obtain an optimized diet with sixty-eight foods with the least difference from the observed population mean dietary intake while meeting a set of nutritional goals that included reduction in the prevalence of inadequate nutrient intakes to ≤20 %. SETTING: Brazil. SUBJECTS: Participants (men and women, n 25 324) aged 20 years or more from the first National Dietary Survey (NDS) 2008-2009...
January 18, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29345182/breast-cancer-screening-among-shift-workers-a-nationwide-population-based-survey-in-korea
#13
Heesook Son, Youngmi Kang
We aimed to examine the association between shift work types and participation in breast cancer screening (BCS) programs by comparing rates of participation for BCS among regular daytime workers and alternative shift workers using data from a nationally representative, population-based survey conducted in Korea. In addition, the results were analyzed according to sociodemographic factors, including occupation, education, income, private health insurance, age, and number of working hours a week. This secondary cross-sectional analysis used data from the 2012 Korean National Health and Nutritional Examination Survey...
January 18, 2018: International Journal of Occupational and Environmental Health
https://www.readbyqxmd.com/read/29345007/aetiology-of-neonatal-conjunctivitis-evaluated-in-a-population-based-setting
#14
Minna Honkila, Marjo Renko, Irma Ikäheimo, Tytti Pokka, Matti Uhari, Terhi Tapiainen
AIM: Our aim was to study prospectively the aetiology of neonatal conjunctivitis in a population-based setting. METHODS: Altogether 173 neonates with clinical conjunctivitis aged on average 20 (SD 10) days were recruited from child welfare clinics in Oulu, Finland, in 2010-2015. Conjunctival specimens were collected from 167 neonates for multiplex polymerase chain reaction to detect 16 respiratory viruses, from 163 for polymerase chain reaction to detect Chlamydia trachomatis and Neisseria gonorrhoeae and from 160 for bacterial culture studies...
January 18, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29344838/association-between-human-brucellosis-and-adverse-pregnancy-outcome-a-cross-sectional-population-based-study
#15
Nesrin Ghanem-Zoubi, Silvia Pessah Eljay, Emilia Anis, Mical Paul
To investigate the association between the incidence of human brucellosis (HB) and adverse pregnancy outcomes (APOs), a population-based, cross-sectional aggregate data study was conducted in Israel between 2010 and 2014. HB-endemic localities were matched by ethnicity, population size and socioeconomic status to localities with a low incidence of HB. We compared APO rates in high-incidence vs low-incidence localities. The primary outcome was intrauterine fetal demise (IUFD). Secondary outcomes were premature birth (less than 37 weeks), early or threatened labour and poor fetal growth...
January 17, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29344677/is-vitamin-d-deficiency-a-public-health-concern-for-low-middle-income-countries-a-systematic-literature-review
#16
Kevin D Cashman, Tony Sheehy, Colette M O'Neill
PURPOSE: Vitamin D deficiency has been receiving increasing attention as a potential public health concern in low and lower-middle income countries (LMICs), of which there are currently 83. We aimed to conduct a comprehensive systematic literature review (SLR) of available data on vitamin D status and prevalence of vitamin D deficiency in all 83 LMICs. METHODS: We followed the general methodology for SLRs in the area of serum 25-hydroxyvitamin D. Highest priority was placed on identifying relevant population-based studies, followed by cross-sectional studies, and to a lesser extent case-control studies...
January 17, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29344632/factors-associated-with-outcomes-and-costs-after-pediatric-laparoscopic-cholecystectomy
#17
Gileh-Gol Akhtar-Danesh, Aristithes G Doumouras, Cecily Bos, Helene Flageole, Dennis Hong
Importance: The prevalence of pediatric cholelithiasis is increasing with the epidemic of childhood obesity. With this rise, the outcomes and costs of pediatric laparoscopic cholecystectomy become an important public health and economic concern. Objective: To assess patient and health system factors associated with the outcomes and costs after laparoscopic cholecystectomy among Canadian children. Design, Setting, and Participants: This was a retrospective, population-based study of children 17 years and younger undergoing laparoscopic cholecystectomy from April 1, 2008, until March 31, 2015...
January 17, 2018: JAMA Surgery
https://www.readbyqxmd.com/read/29344384/blood-pressure-target-achievement-and-antihypertensive-medication-use-in-women-and-men-after-first-ever-myocardial-infarction-the-troms%C3%A3-study-1994-2016
#18
Laila A Hopstock, Anne Elise Eggen, Maja-Lisa Løchen, Ellisiv B Mathiesen, Amalie Nilsen, Inger Njølstad, Tom Wilsgaard
Background: Recurrent cardiovascular events after myocardial infarction (MI) are frequent, and gender differences in blood pressure treatment have been reported. Despite increased focus on secondary prevention, recent reports indicate that treatment targets are not achieved. There is a need for gender-specific analyses of post-MI blood pressure treatment target achievement and antihypertensive medication adherence. Design: We investigated the change in systolic and diastolic blood pressure and antihypertensive drug use after first-ever MI over two time periods in a Norwegian population-based study...
2018: Open Heart
https://www.readbyqxmd.com/read/29343988/does-breast-density-measured-through-population-based-screening-independently-increase-breast-cancer-risk-in-asian-females
#19
Boyoung Park, Hye Mi Cho, Eun Hye Lee, Seunghoon Song, Mina Suh, Kui Son Choi, Bong Joo Kang, Kyungran Ko, Ann Yi, Hae Kyoung Jung, Joo Hee Cha, Jae Kwan Jun
Purpose: The purpose of this study was to investigate the effects of breast density on breast cancer risk among women screened via a nationwide mammographic screening program. Patients and methods: We conducted a nested case-control study for a randomly selected population of 1,561 breast cancer patients and 6,002 matched controls from the National Cancer Screening Program. Breast density was measured and recorded by two independent radiologists using the Breast Imaging Reporting and Data System (BI-RADS)...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29343840/vision-status-in-older-adults-the-brazilian-amazon-region-eye-survey
#20
Solange R Salomão, Adriana Berezovsky, João M Furtado, Arthur G Fernandes, Sergio Muñoz, Nívea N Cavascan, Marcela C Cypel, Cristina C Cunha, Galton C Vasconcelos, Márcia R K H Mitsuhiro, Paula Y Sacai, Mauro Campos, Paulo H A Morales, Marcos J Cohen, Jacob M Cohen, Sung E S Watanabe, Rubens Belfort
Older adults living in remote areas with limited access to health services are at higher risk to develop visual impairment and blindness. We conducted a population-based survey to determine the vision status in subjects 45 years of age and older from urban and rural areas of Parintins city, Brazilian Amazon Region. Participants underwent ophthalmic examination, including uncorrected (UCVA), presenting (PVA) and best-corrected visual acuity (BCVA). Vision status was described as lines of visual acuity (VA) impairment and lines of VA improvement from UCVA to BCVA and from PVA to BCVA in the better-seeing eye...
January 17, 2018: Scientific Reports
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