Jie Cui, Filip Mivalt, Vladimir Sladky, Jiwon Kim, Thomas J Richner, Brian N Lundstrom, Jamie J Van Gompel, Hai-Long Wang, Kai J Miller, Nicholas M Gregg, Long Jun Wu, Timothy Denison, Bailey Winter, Benjamin H Brinkmann, Vaclav Kremen, Gregory A Worrell
Objective: This study aims to characterize the time course of impedance, a crucial electrophysiological proper-ty of brain tissue, in the human thalamus (THL), amygdala-hippocampus (AMG-HPC), and poste-rior hippocampus (post-HPC) over an extended period. Approach: Impedance was periodically sampled every 5-15 minutes over several months in five subjects with drug-resistant epilepsy using an experimental neuromodulation device. Initially, we employed de-scriptive piecewise and continuous mathematical models to characterize the impedance response for approximately three weeks post-electrode implantation...
March 14, 2024: Journal of Neural Engineering