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Epilepsy device

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https://www.readbyqxmd.com/read/29324507/determining-when-to-stop-antiepileptic-drug-treatment
#1
Steven C Schachter
PURPOSE OF REVIEW: As the number of patients diagnosed with epilepsy continues to rise and the pharmacological and device-based treatment options for epilepsy increase, determining when to stop antiepileptic drug (AED) treatment continues to be an important issue for patient management and counseling. RECENT FINDINGS: This review focuses on outcomes following AED withdrawal in seizure-free adults with epilepsy. Practical considerations are also discussed because, despite the importance of this topic, relatively little progress has been made in the past year regarding the identification of patients whose risk for recurrent seizures after AED withdrawal is no higher than that of the general population...
January 10, 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29311566/multi-day-rhythms-modulate-seizure-risk-in-epilepsy
#2
Maxime O Baud, Jonathan K Kleen, Emily A Mirro, Jason C Andrechak, David King-Stephens, Edward F Chang, Vikram R Rao
Epilepsy is defined by the seemingly random occurrence of spontaneous seizures. The ability to anticipate seizures would enable preventative treatment strategies. A central but unresolved question concerns the relationship of seizure timing to fluctuating rates of interictal epileptiform discharges (here termed interictal epileptiform activity, IEA), a marker of brain irritability observed between seizures by electroencephalography (EEG). Here, in 37 subjects with an implanted brain stimulation device that detects IEA and seizures over years, we find that IEA oscillates with circadian and subject-specific multidien (multi-day) periods...
January 8, 2018: Nature Communications
https://www.readbyqxmd.com/read/29297653/mechanism-of-action-of-non-invasive-cervical-vagus-nerve-stimulation-for-the-treatment-of-primary-headaches
#3
Bruce Simon, Justyna Blake
Stimulation of the cervical vagus nerve with implanted vagus nerve stimulation (iVNS) has been used clinically for more than 20 years to treat patients with epilepsy. More recently, a non-invasive cervical vagus nerve stimulation (nVNS), gammaCore, was developed, which has been purported to also stimulate the vagus nerve without the cost and morbidity associated with an iVNS system. gammaCore has been used to acutely treat various types of primary headaches, including migraine and cluster headaches (CH), and for the prevention of episodic, chronic, and menstrual migraines and CH...
November 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/29295522/comparison-between-scalp-eeg-and-behind-the-ear-eeg-for-development-of-a-wearable-seizure-detection-system-for-patients-with-focal-epilepsy
#4
Ying Gu, Evy Cleeren, Jonathan Dan, Kasper Claes, Wim Van Paesschen, Sabine Van Huffel, Borbála Hunyadi
A wearable electroencephalogram (EEG) device for continuous monitoring of patients suffering from epilepsy would provide valuable information for the management of the disease. Currently no EEG setup is small and unobtrusive enough to be used in daily life. Recording behind the ear could prove to be a solution to a wearable EEG setup. This article examines the feasibility of recording epileptic EEG from behind the ear. It is achieved by comparison with scalp EEG recordings. Traditional scalp EEG and behind-the-ear EEG were simultaneously acquired from 12 patients with temporal, parietal, or occipital lobe epilepsy...
December 23, 2017: Sensors
https://www.readbyqxmd.com/read/29291239/seizure-forecasting-from-idea-to-reality-outcomes-of-the-my-seizure-gauge-epilepsy-innovation-institute-workshop
#5
Sonya B Dumanis, Jaqueline A French, Christophe Bernard, Gregory A Worrell, Brandy E Fureman
The Epilepsy Innovation Institute (Ei2) is a new research program of the Epilepsy Foundation designed to be an innovation incubator for epilepsy. Ei2 research areas are selected based on community surveys that ask people impacted by epilepsy what they would like researchers to focus on. In their 2016 survey, unpredictability was selected as a top issue regardless of seizure frequency or severity. In response to this need, Ei2 launched the My Seizure Gauge challenge, with the end goal of creating a personalized seizure advisory system device...
November 2017: ENeuro
https://www.readbyqxmd.com/read/29287215/impact-of-vagus-nerve-stimulation-on-sleep-related-breathing-disorders-in-adults-with-epilepsy
#6
Aude Salvadé, Philippe Ryvlin, Andrea O Rossetti
BACKGROUND: Vagus nerve stimulation (VNS) can induce a sleep apnea syndrome (SAS), which in turn can worsen seizure control and represents a cardiovascular risk factor. Epidemiology of VNS-induced SAS has received little attention to date. The purpose of this study was to estimate the VNS-induced SAS prevalence and to explore clinical variables potentially correlating with its development. METHODS: We analyzed the computerized medical records of 18 consecutive adults treated for refractory epilepsy with VNS, implanted between May 2008 and October 2015...
December 26, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29262385/-experience-and-solution-of-complications-of-vagus-nerve-stimulation-therapy-in-139-implant-patients-with-medically-refractory-epilepsy
#7
Daiki Uchida, Takamichi Yamamoto, Tomohiro Yamazoe, Kentaro Iijima, Ayataka Fujimoto, Hideo Enoki, Tokutaro Tanaka
BACKGROUND: Vagus nerve stimulation(VNS)for patients with intractable epilepsy was approved by the Japan Ministry of Health, Labour and Welfare in 2010. More than 1,500 VNS systems were implanted by the end of August 2016. The aim of the present report is to describe complications we experienced at our department and consider the way to avoid them. METHODS AND PATIENTS: We retrospectively reviewed 139 consecutive patients(122 new implantations and 17 reimplantations)between December 2010 and March 2016...
December 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/29185556/online-tools-for-individuals-with-depression-and-neurologic-conditions-a-scoping-review
#8
REVIEW
Sara Lukmanji, Tram Pham, Laura Blaikie, Callie Clark, Nathalie Jetté, Samuel Wiebe, Andrew Bulloch, Jayna Holroyd-Leduc, Sophia Macrodimitris, Aaron Mackie, Scott B Patten
Background: Patients with neurologic conditions commonly have depression. Online tools have the potential to improve outcomes in these patients in an efficient and accessible manner. We aimed to identify evidence-informed online tools for patients with comorbid neurologic conditions and depression. Methods: A scoping review of online tools (free, publicly available, and not requiring a facilitator) for patients with depression and epilepsy, Parkinson disease (PD), multiple sclerosis (MS), traumatic brain injury (TBI), or migraine was conducted...
August 2017: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/29144716/mechanism-of-action-of-non-invasive-cervical-vagus-nerve-stimulation-for-the-treatment-of-primary-headaches
#9
Bruce Simon, Justyna Blake
Stimulation of the cervical vagus nerve with implanted vagus nerve stimulation (iVNS) has been used clinically for more than 20 years to treat patients with epilepsy. More recently, a non-invasive cervical vagus nerve stimulation (nVNS), gammaCore, was developed, which has been purported to also stimulate the vagus nerve without the cost and morbidity associated with an iVNS system. gammaCore has been used to acutely treat various types of primary headaches, including migraine and cluster headaches (CH), and for the prevention of episodic, chronic, and menstrual migraines and CH...
November 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/29128586/contraception-pregnancy-and-peripartum-experiences-among-women-with-epilepsy-in-bhutan
#10
Sheliza Halani, Lhab Tshering, Esther Bui, Sarah J Clark, Sara J Grundy, Tandin Pem, Sonam Lhamo, Ugyen Dema, Damber K Nirola, Chencho Dorji, Farrah J Mateen
INTRODUCTION: Reports on the reproductive health of women with epilepsy (WWE) in low- and middle-income countries (LMICs) are limited. Bhutan is a lower income country with a high estimated prevalence of epilepsy and no out-of-pocket payment requirements for health visits or medications. METHODS: We developed a 10-category survey to interview WWE ages 20-59 years in the Kingdom of Bhutan to understand their contraceptive use and peripartum experiences. WWE were recruited from 2016-2017 from an existing epilepsy cohort and their reproductive health data were merged with epilepsy and socioeconomic data obtained from initial clinical evaluations performed between 2014 and 2016...
December 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29096220/ear-eeg-detects-ictal-and-interictal-abnormalities-in-focal-and-generalized-epilepsy-a-comparison-with-scalp-eeg-monitoring
#11
I C Zibrandtsen, P Kidmose, C B Christensen, T W Kjaer
OBJECTIVE: Ear-EEG is recording of electroencephalography from a small device in the ear. This is the first study to compare ictal and interictal abnormalities recorded with ear-EEG and simultaneous scalp-EEG in an epilepsy monitoring unit. METHODS: We recorded and compared simultaneous ear-EEG and scalp-EEG from 15 patients with suspected temporal lobe epilepsy. EEGs were compared visually by independent neurophysiologists. Correlation and time-frequency analysis was used to quantify the similarity between ear and scalp electrodes...
October 12, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29071466/cardiovascular-autonomic-effects-of-vagus-nerve-stimulation
#12
REVIEW
Iñigo Garamendi-Ruiz, Juan Carlos Gómez-Esteban
The vagus nerve is responsible for the parasympathetic innervation of the major thoracic and abdominal organs. It also carries sensory afferent fibres from these viscera and reaches different brain structures. These connections have proven useful in the treatment of different diseases. Afferent stimulation of the left vagus nerve is used to treat epilepsy and major depression, and stimulation of the right vagus nerve is being tried for the treatment of heart failure. The device used for the therapy delivers intermittent stimuli...
October 25, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/29060794/modified-automatic-r-peak-detection-algorithm-for-patients-with-epilepsy-using-a-portable-electrocardiogram-recorder
#13
J Jeppesen, S Beniczky, A Fuglsang Frederiksen, P Sidenius, P Johansen
Earlier studies have shown that short term heart rate variability (HRV) analysis of ECG seems promising for detection of epileptic seizures. A precise and accurate automatic R-peak detection algorithm is a necessity in a real-time, continuous measurement of HRV, in a portable ECG device. We used the portable CE marked ePatch® heart monitor to record the ECG of 14 patients, who were enrolled in the videoEEG long term monitoring unit for clinical workup of epilepsy. Recordings of the first 7 patients were used as training set of data for the R-peak detection algorithm and the recordings of the last 7 patients (467...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29060344/low-latency-vlsi-architecture-for-neural-cross-frequency-coupling-analysis
#14
Gerard O'Leary, Taufik A Valiante, Roman Genov
Growing evidence suggests that cross-frequency coupling (CFC) is a key mechanism in neuronal computation, communication, and learning in the brain. Abnormal CFC has been implicated in pathological brain states such as epilepsy and Parkinson's disease. A reduction in excessive coupling has been shown in effective neuromodulation treatments, suggesting that CFC may be a useful feedback measure in closed-loop neural stimulation devices. However, processing latency limits the responsiveness of such systems. A VLSI architecture is presented which implements three selectable measures of CFC to enable the application specific trade-off between low-latency and high-accuracy processing...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29059865/design-of-focal-brain-cooling-system-for-suppressing-epileptic-seizures
#15
Kei Hata, Koichi Fujiwara, Manabu Kano, Takao Inoue, Sadahiro Nomura, Hirochika Imoto, Michiyasu Suzuki
Epilepsy is a group of diseases caused by excessive neuronal activities, and one-quarter of the patients do not become seizure-free by the existing treatments. The potential treatments include focal brain cooling, which aims to cool the region where the excessive neuronal activities begin. We are developing a focal brain cooling system. The system delivers cold saline to a cranially implanted cooling device. The outflow is cooled by a Peltier device and pumped for circulation. The Peltier device and the pump are activated only when a seizure is predicted...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29059838/a-low-power-flash-fpga-based-brain-implant-micro-system-of-pid-control
#16
Lijuan Xia, Nabeel Fattah, Ahmed Soltan, Andrew Jackson, Graeme Chester, Patrick Degenaar
In this paper, we demonstrate that a low power flash FPGA based micro-system can provide a low power programmable interface for closed-loop brain implant inter- faces. The proposed micro-system receives recording local field potential (LFP) signals from an implanted probe, performs closed-loop control using a first order control system, then converts the signal into an optogenetic control stimulus pattern. Stimulus can be implemented through optoelectronic probes. The long term target is for both fundamental neuroscience applications and for clinical use in treating epilepsy...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29029236/first-in-human-experience-with-complete-integration-of-neuromodulation-device-within-a-customized-cranial-implant
#17
Chad R Gordon, Gabriel F Santiago, Judy Huang, Gregory K Bergey, Shuya Liu, Mehran Armand, Henry Brem, William S Anderson
BACKGROUND: Neuromodulation devices have the potential to transform modern day treatments for patients with medicine-resistant neurological disease. For instance, the NeuroPace System (NeuroPace Inc, Mountain View, California) is a Food and Drug Administration (FDA)-approved device developed for closed-loop direct brain neurostimulation in the setting of drug-resistant focal epilepsy. However, current methods require placement either above or below the skull in nonanatomic locations. This type of positioning has several drawbacks including visible deformities and scalp pressure from underneath leading to eventual wound healing difficulties, micromotion of hardware with infection, and extrusion leading to premature explantation...
October 6, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29027928/automated-epileptic-seizure-detection-based-on-wearable-ecg-and-ppg-in-a-hospital-environment
#18
Kaat Vandecasteele, Thomas De Cooman, Ying Gu, Evy Cleeren, Kasper Claes, Wim Van Paesschen, Sabine Van Huffel, Borbála Hunyadi
Electrocardiography has added value to automatically detect seizures in temporal lobe epilepsy (TLE) patients. The wired hospital system is not suited for a long-term seizure detection system at home. To address this need, the performance of two wearable devices, based on electrocardiography (ECG) and photoplethysmography (PPG), are compared with hospital ECG using an existing seizure detection algorithm. This algorithm classifies the seizures on the basis of heart rate features, extracted from the heart rate increase...
October 13, 2017: Sensors
https://www.readbyqxmd.com/read/29018634/detection-of-paroxysms-in-long-term-single-channel-eeg-monitoring-of-patients-with-typical-absence-seizures
#19
Troels W Kjaer, Helge B D Sorensen, Sabine Groenborg, Charlotte R Pedersen, Jonas Duun-Henriksen
Absence seizures are associated with generalized 2.5-5 Hz spike-wave discharges in the electroencephalogram (EEG). Rarely are patients, parents, or physicians aware of the duration or incidence of seizures. Six patients were monitored with a portable EEG-device over four times 24 h to evaluate how easily outpatients are monitored and how well an automatic seizure detection algorithm can identify the absences. Based on patient-specific modeling, we achieved a sensitivity of 98.4% with only 0.23 false detections per hour...
2017: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/28994627/mybrain-a-novel-eeg-embedded-system-for-epilepsy-monitoring
#20
Francisco Pinho, João Cerqueira, José Correia, Nuno Sousa, Nuno Dias
The World Health Organisation has pointed that a successful health care delivery, requires effective medical devices as tools for prevention, diagnosis, treatment and rehabilitation. Several studies have concluded that longer monitoring periods and outpatient settings might increase diagnosis accuracy and success rate of treatment selection. The long-term monitoring of epileptic patients through electroencephalography (EEG) has been considered a powerful tool to improve the diagnosis, disease classification, and treatment of patients with such condition...
October 10, 2017: Journal of Medical Engineering & Technology
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