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https://www.readbyqxmd.com/read/29766029/seizure-suppressant-and-neuroprotective-effects-of-encapsulated-bdnf-producing-cells-in-a-rat-model-of-temporal-lobe-epilepsy
#1
Chiara Falcicchia, Giovanna Paolone, Dwaine F Emerich, Francesca Lovisari, William J Bell, Tracie Fradet, Lars U Wahlberg, Michele Simonato
Brain-derived neurotrophic factor (BDNF) may represent a therapeutic for chronic epilepsy, but evaluating its potential is complicated by difficulties in its delivery to the brain. Here, we describe the effects on epileptic seizures of encapsulated cell biodelivery (ECB) devices filled with genetically modified human cells engineered to release BDNF. These devices, implanted into the hippocampus of pilocarpine-treated rats, highly decreased the frequency of spontaneous seizures by more than 80%. These benefits were associated with improved cognitive performance, as epileptic rats treated with BDNF performed significantly better on a novel object recognition test...
June 15, 2018: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/29756178/hippocampal-deep-brain-stimulation-persistent-seizure-control-after-bilateral-extra-cranial-electrode-fracture
#2
Massimo Piacentino, Giacomo Beggio, Lara Zordan, Paolo Bonanni
Hippocampal deep brain stimulation (DBS) can provide an effective alternative for intractable temporal lobe epilepsy. In this case report, we describe a peculiar outcome after a post-traumatic wire-disconnection of a bilateral hippocampal DBS device. The patient presented a postoperative long-term significant reduction in seizure frequency even with an absent electric stimulation. This case gives the possibility to consider alternatives in epilepsy surgery, based on stimulation interference (lesional or electrical disturbing) in the epileptogenic zone...
May 13, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29749917/a-novel-neural-prosthesis-providing-long-term-electrocorticography-recording-and-cortical-stimulation-for-epilepsy-and-brain-computer-interface
#3
Pantaleo Romanelli, Marco Piangerelli, David Ratel, Christophe Gaude, Thomas Costecalde, Cosimo Puttilli, Mauro Picciafuoco, Alim Benabid, Napoleon Torres
OBJECTIVE Wireless technology is a novel tool for the transmission of cortical signals. Wireless electrocorticography (ECoG) aims to improve the safety and diagnostic gain of procedures requiring invasive localization of seizure foci and also to provide long-term recording of brain activity for brain-computer interfaces (BCIs). However, no wireless devices aimed at these clinical applications are currently available. The authors present the application of a fully implantable and externally rechargeable neural prosthesis providing wireless ECoG recording and direct cortical stimulation (DCS)...
May 11, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29748207/use-of-diffusional-kurtosis-imaging-and-dynamic-contrast-enhanced-mr-imaging-to-predict-posttraumatic-epilepsy-in-rabbits
#4
W Li, X Wang, X Wei, M Wang
BACKGROUND AND PURPOSE: Finding a reliable biomarker to thoroughly assess the brain structure changes in posttraumatic epilepsy is of great importance. Our aim was to explore the value of diffusional kurtosis imaging combined with dynamic contrast-enhanced MR imaging in the evaluation of posttraumatic epilepsy. MATERIALS AND METHODS: A modified weight-drop device was used to induce traumatic brain injury. Rabbits were exposed to traumatic brain injury or sham injury...
May 10, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29747022/detection-of-generalized-tonic-clonic-seizures-from-ear-eeg-based-on-emg-analysis
#5
I C Zibrandtsen, P Kidmose, T W Kjaer
PURPOSE: Sudden unexpected death in epilepsy (SUDEP) is associated with generalized tonic-clonic seizures (GTCS) with most deaths occurring during sleep. Seizure detection devices have been suggested as a SUDEP prevention strategy. EMG-based GTCS detection can take advantage of the GTCS characteristic of sustained high-amplitude, high-frequency activity in the time-domain. METHOD: We present a GTCS-detection method based on median-filtered variance estimates on surface EMG measurements and describe its performance in a small exploratory proof-of-concept setting involving a group of 15 patients with 3 GTCS recorded with ear-EEG and another group of 6 patients with 11 GTCS recorded with scalp-EEG...
May 4, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29724661/ifcn-endorsed-practical-guidelines-for-clinical-magnetoencephalography-meg
#6
REVIEW
Riitta Hari, Sylvain Baillet, Gareth Barnes, Richard Burgess, Nina Forss, Joachim Gross, Matti Hämäläinen, Ole Jensen, Ryusuke Kakigi, François Mauguière, Nobukatzu Nakasato, Aina Puce, Gian-Luca Romani, Alfons Schnitzler, Samu Taulu
Magnetoencephalography (MEG) records weak magnetic fields outside the human head and thereby provides millisecond-accurate information about neuronal currents supporting human brain function. MEG and electroencephalography (EEG) are closely related complementary methods and should be interpreted together whenever possible. This manuscript covers the basic physical and physiological principles of MEG and discusses the main aspects of state-of-the-art MEG data analysis. We provide guidelines for best practices of patient preparation, stimulus presentation, MEG data collection and analysis, as well as for MEG interpretation in routine clinical examinations...
April 17, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29722352/epilepsy
#7
REVIEW
Orrin Devinsky, Annamaria Vezzani, Terence J O'Brien, Nathalie Jette, Ingrid E Scheffer, Marco de Curtis, Piero Perucca
Epilepsy affects all age groups and is one of the most common and most disabling neurological disorders. The accurate diagnosis of seizures is essential as some patients will be misdiagnosed with epilepsy, whereas others will receive an incorrect diagnosis. Indeed, errors in diagnosis are common, and many patients fail to receive the correct treatment, which often has severe consequences. Although many patients have seizure control using a single medication, others require multiple medications, resective surgery, neuromodulation devices or dietary therapies...
May 3, 2018: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29722015/east-sesame-syndrome-review-of-the-literature-and-introduction-of-four-new-latvian-patients
#8
REVIEW
C Marta, M Ieva, I Inna, A Mareta, K Sandra, J Pereca, S Janis, P Dita, S Jurgis
EAST (Epilepsy, Ataxia, Sensorineural deafness, Tubulopathy) or SeSAME (Seizures, Sensorineural deafness, Ataxia, Mental retardation, and Electrolyte imbalance) syndrome is a rare autosomal recessive syndrome first described in 2009 independently by Bockenhauer and Scholl. It is caused by mutations in KCNJ10, which encodes Kir4.1, an inwardly rectifying K+ channel found in the brain, inner ear, kidney and eye. To date, 16 mutations in at least 28 patients have been reported. In this paper, we review mutations causing EAST/SeSAME syndrome, clinical manifestations in detail, and efficacy of treatment in previously reported patients...
May 3, 2018: Clinical Genetics
https://www.readbyqxmd.com/read/29702412/vagus-nerve-stimulation-for-6-to-12-year-old-children-with-refractory-epilepsy-impact-on-seizure-frequency-and-parenting-stress-index
#9
Hueng-Chuen Fan, Ting-Rong Hsu, Kai-Ping Chang, Shyi-Jou Chen, Jeng-Dau Tsai
OBJECTIVES: Refractory epilepsy (RE) is frequently associated with neuropsychological impairment in children and may disrupt their social development. Vagus nerve stimulation (VNS) had been reported to have beneficial effects on behavioral outcomes. The aim of this study was to compare Parenting Stress Index (PSI) scores before and after VNS device implantation in children with RE, especially those who experienced seizure frequency reduction. METHODS: We conducted a one-group pretest-posttest study in school age children with RE...
April 24, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29702409/clinical-outcomes-of-vns-therapy-with-aspiresr-%C3%A2-including-cardiac-based-seizure-detection-at-a-large-complex-epilepsy-and-surgery-centre
#10
Preci Hamilton, Imad Soryal, Prince Dhahri, Welege Wimalachandra, Anna Leat, Denise Hughes, Nicole Toghill, James Hodson, Vijay Sawlani, Tom Hayton, Shanika Samarasekera, Manny Bagary, Dougall McCorry, Ramesh Chelvarajah
PURPOSE: To compare the efficacy of AspireSR® to preceding VNS battery models for battery replacements, and to determine the efficacy of the AspireSR® for new implants. METHODS: Data were collected retrospectively from patients with epilepsy who had VNS AspireSR® implanted over a three-year period between June 2014 and June 2017 by a single surgeon. Cases were divided into two cohorts, those in whom the VNS was a new insertion, and those in whom the VNS battery was changed from a previous model to AspireSR® ...
March 28, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29670050/epilepsy-and-neuromodulation-randomized-controlled-trials
#11
Churl-Su Kwon, Valeria Ripa, Omar Al-Awar, Fedor Panov, Saadi Ghatan, Nathalie Jetté
Neuromodulation is a treatment strategy that is increasingly being utilized in those suffering from drug-resistant epilepsy who are not appropriate for resective surgery. The number of double-blinded RCTs demonstrating the efficacy of neurostimulation in persons with epilepsy is increasing. Although reductions in seizure frequency is common in these trials, obtaining seizure freedom is rare. Invasive neuromodulation procedures (DBS, VNS, and RNS) have been approved as therapeutic measures. However, further investigations are necessary to delineate effective targeting, minimize side effects that are related to chronic implantation and to improve the cost effectiveness of these devices...
April 18, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29667458/sudden-unexpected-death-in-epilepsy-ongoing-challenges-in-finding-mechanisms-and-prevention
#12
Doungporn Ruthirago, Parunyou Julayanont, Amputch Karukote, Mohamed Shehabeldin, Kenneth Nugent
Patients with epilepsy have a significantly higher risk of death than the general population. Sudden unexpected death in epilepsy (SUDEP) is the leading cause of sudden death among patients with epilepsy. Despite on-going research, there are still deficits in our knowledge about the mechanisms, genetic factors, and prevention of SUDEP. Current evidence suggests that cardiac arrhythmias, respiratory dysfunction, and brainstem arousal system dysfunction are the major mechanisms of SUDEP, and animal models support the role of neurotransmitters, especially serotonin and adenosine, in pathophysiology of SUDEP...
April 18, 2018: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29651891/use-of-vagus-nerve-stimulator-on-children-with-primary-generalized-epilepsy
#13
William P Welch, Bilal Sitwat, Yoshimi Sogawa
OBJECTIVE: To describe the response to vagus nerve stimulator (VNS) in otherwise neurotypical children with medically intractable primary generalized epilepsy. METHODS: Retrospective chart review of patients who underwent vagus nerve stimulator surgery between January 2011 and December 2015. RESULTS: Eleven patients were identified. Median follow-up duration was 2.5 years (1.2-8.4 years). Prior to vagus nerve stimulator surgery, all patients had at least 1 seizure per week, and 7/11 (64%) had daily seizures...
January 1, 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29621570/mne-scan-software-for-real-time-processing-of-electrophysiological-data
#14
Lorenz Esch, Limin Sun, Viktor Klüber, Seok Lew, Daniel Baumgarten, P Ellen Grant, Yoshio Okada, Jens Haueisen, Matti S Hämäläinen, Christoph Dinh
BACKGROUND: Magnetoencephalography (MEG) and Electroencephalography (EEG) are noninvasive techniques to study the electrophysiological activity of the human brain. Thus, they are well suited for real-time monitoring and analysis of neuronal activity. Real-time MEG/EEG data processing allows adjustment of the stimuli to the subject's responses for optimizing the acquired information especially by providing dynamically changing displays to enable neurofeedback. NEW METHOD: We introduce MNE Scan, an acquisition and real-time analysis software based on the multipurpose software library MNE-CPP...
April 2, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29608227/estimating-long-term-vagus-nerve-stimulation-effectiveness-accounting-for-antiepileptic-drug-treatment-changes
#15
David Révész, Victoria Fröjd, Bertil Rydenhag, Elinor Ben-Menachem
OBJECTIVE: To investigate the effectiveness of vagus nerve stimulation (VNS) in combination with pharmacological therapy in a longitudinal retrospective study at a single center. MATERIALS AND METHODS: Data from 130 consecutive patients implanted with a VNS device between the years 2000 and 2013 was analyzed. Seizure frequency and pharmacological antiepileptic drug (AED) treatments were recorded prior to as well as at one, two, and five years after VNS implantation...
April 2, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29604050/common-data-elements-for-epilepsy-mobile-health-systems
#16
Daniel M Goldenholz, Robert Moss, David A Jost, Nathan E Crone, Gregory Krauss, Rosalind Picard, Chiara Caborni, Jose E Cavazos, John Hixson, Tobias Loddenkemper, Tracy Dixon Salazar, Laura Lubbers, Lauren C Harte-Hargrove, Vicky Whittemore, Jonas Duun-Henriksen, Eric Dolan, Nitish Kasturia, Mark Oberemk, Mark J Cook, Mark Lehmkuhle, Michael R Sperling, Patricia O Shafer
OBJECTIVE: Common data elements (CDEs) are currently unavailable for mobile health (mHealth) in epilepsy devices and related applications. As a result, despite expansive growth of new digital services for people with epilepsy, information collected is often not interoperable or directly comparable. We aim to correct this problem through development of industry-wide standards for mHealth epilepsy data. METHODS: Using a group of stakeholders from industry, academia, and patient advocacy organizations, we offer a consensus statement for the elements that may facilitate communication among different systems...
March 31, 2018: Epilepsia
https://www.readbyqxmd.com/read/29598890/closed-loop-intracranial-stimulation-alters-movement-timing-in-humans
#17
Bartlett D Moore, Adam R Aron, Nitin Tandon
BACKGROUND: A prime objective driving the recent development of human neural prosthetics is to stimulate neural circuits in a manner time-locked to ongoing brain activity. The human supplementary motor area (SMA) is a particularly useful target for this objective because it displays characteristic neural activity just prior to voluntary movement. OBJECTIVE: Here, we tested a method that detected activity in the human SMA related to impending movement and then delivered cortical stimulation with intracranial electrodes to influence the timing of movement...
March 8, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29588969/neurostimulation-as-a-promising-epilepsy-therapy
#18
REVIEW
Yicong Lin, Yuping Wang
The revolution in theory, swift technological developments, and invention of new devices have driven tremendous progress in neurostimulation as a third-line treatment for epilepsy. Over the past decades, neurostimulation took its place in the field of epilepsy as an advanced treatment technique and opened up a new world. Numerous animal studies have proven the physical efficacy of stimulation of the brain and peripheral nerves. Based on this optimistic fundamental research, new advanced techniques are being explored in clinical practice...
December 2017: Epilepsia Open
https://www.readbyqxmd.com/read/29567875/-3-new-therapeutic-modalities-using-seizure-detection-devices-for-medically-refractory-epilepsy-aspiresr-and-the-rns-system
#19
Takamichi Yamamoto, Motoki Inaji, Taketoshi Maehara, Kensuke Kawai, Werner K Doyle
No abstract text is available yet for this article.
March 2018: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/29555606/vagal-nerve-stimulator-malfunction-with-change-in-neck-position-case-report-and-literature-review
#20
Erin D'Agostino, Vyacheslav Makler, David F Bauer
BACKGROUND: Vagal nerve stimulation (VNS) is a safe and well-tolerated treatment for drug resistant epilepsy. Complications and failure of the device can result from lead fracture, device malfunction, disconnection, or battery displacement and can result in a variety of symptoms. We present an interesting case of stimulator malfunction with increased impedance change seen only with a change in head position. CASE DESCRIPTION: Patient is a 25-year-old male with a vagal nerve stimulator (VNs) placed for medically refractory epilepsy who presented with neck pain and an electrical pulling sensation in his neck whenever he turned his head to the right...
March 16, 2018: World Neurosurgery
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