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Acute Kidney Injury: the role of biomarkers for early diagnosis

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https://www.readbyqxmd.com/read/27676272/early-predictors-of-acute-kidney-injury-a-narrative-review
#1
Xiaoqin Liu, Yi Guan, Sheng Xu, Qingzhao Li, Yuanbo Sun, Ruijie Han, Chunyang Jiang
Accompanied with the broad application of interventional therapy, the incidence of acute kidney injury (AKI) has been recently increasing in clinical renal medicine. The pathogenesis of AKI is diverse and complex. In the context of the requirements for the diagnosis and treatment of a renal disorder, a large number of studies have explored biological markers and their usefulness to the early diagnosis and treatment of AKI, including glomerular injury, renal tubular injury, and others. These biomarkers provide an important basis for early monitoring of AKI, but are still not quite sufficient...
2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27634440/cell-cycle-arrest-as-a-therapeutic-target-of-acute-kidney-injury
#2
Wei-Gang Wang, Wei-Xia Sun, Bao-Shan Gao, Xin Lian, Hong-Lan Zhou
The current lack of complete understanding of the pathogenesis of acute kidney injury (AKI) is a significant barrier to its early diagnosis and treatment. Cell cycle arrest plays an important role in the protection of renal tubular epithelial cells and maladaptive repair following AKI. G1 phase cell arrest serves as a protective mechanism following AKI, avoiding replication of damaged DNA. Insulin-like growth factor-binding protein 7 (IGFBP7) and tissue inhibitor of metalloproteinase-2 (TIMP-2) are closely associated with G1 cell cycle arrest during the very early phase of cellular damage and can serve as an ideal biomarker to predict AKI...
September 15, 2016: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/27485279/kidney-disease-and-the-nexus-of-chronic-kidney-disease-and-acute-kidney-injury-the-role-of-novel-biomarkers-as-early-and-accurate%C3%A2-diagnostics
#3
REVIEW
Murthy Yerramilli, Giosi Farace, John Quinn, Maha Yerramilli
Chronic kidney disease (CKD) and acute kidney injury (AKI) are interconnected and the presence of one is a risk for the other. CKD is an important predictor of AKI after exposure to nephrotoxic drugs or major surgery, whereas persistent or repetitive injury could result in the progression of CKD. This brings new perspectives to the diagnosis and monitoring of kidney diseases highlighting the need for a panel of kidney-specific biomarkers that reflect functional as well as structural damage and recovery, predict potential risk and provide prognosis...
November 2016: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/27429539/progression-of-chronic-kidney-disease-after-acute-kidney-injury
#4
Prasad Devarajan, John Lynn Jefferies
The incidence of chronic kidney disease (CKD) in children and adults is increasing. Cardiologists have become indispensable members of the care provider team for children with CKD. This is partly due to the high incidence of CKD in children and adults with congenital heart disease, with current estimates of 30-50%. In addition, the high incidence of acute kidney injury (AKI) due to cardiac dysfunction or following pediatric cardiac surgery that may progress to CKD is also well documented. It is now apparent that AKI and CKD are uniquely intertwined as interconnected syndromes...
June 2016: Progress in Pediatric Cardiology
https://www.readbyqxmd.com/read/27240440/a-promising-marker-in-early-diagnosis-of-septic-acute-kidney-injury-of-critically-ill-patients-urine-insulin-like-growth-factor-binding-protein-7
#5
Müge Aydoğdu, Nazlıhan Boyacı, Seher Yüksel, Gül Gürsel, Ayşe Banu Çaycı Sivri
AIM: An ideal biomarker for early diagnosis of septic acute kidney injury (AKI) should reflect renal stress or damage at initiation point, at cellular level. The aim of this study was to assess the role of a urinary cell cycle arrest marker, insulin-like growth factor-binding protein 7 (IGFBP7) in early diagnosis of septic AKI in adult critical care patients. METHODS: This was a single-center prospective cohort study. Patients without AKI, admitted to a medical intensive care unit (ICU) between January 2010 and March 2013, were included...
September 2016: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/27126472/micrornas-and-drug-induced-kidney-injury
#6
REVIEW
Mira Pavkovic, Vishal S Vaidya
Drug-induced kidney injury (DIKI) is a severe complication in hospitalized patients associated with higher probabilities of developing progressive chronic kidney disease or end-stage renal diseases. Furthermore, DIKI is a problem during preclinical and clinical phases of drug development leading to high rates of project terminations. Understanding the molecular perturbations caused by DIKI would pave the way for a new class of therapeutics to mitigate the damage. Yet, another approach to ameliorate DIKI is identifying sensitive and specific translational biomarkers that outperform the current diagnostic analytes like serum creatinine and facilitate early diagnosis...
July 2016: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27055689/urinary-markers-of-acute-kidney-injury-in-newborns-with-perinatal-asphyxia
#7
Mehmet Yekta Oncel, Fuat Emre Canpolat, Sema Arayici, Evrim Alyamac Dizdar, Nurdan Uras, Serife Suna Oguz
BACKGROUND: Acute kidney injury (AKI) affects up to 60% of severely asphyxiated neonates. The diagnosis of AKI can be and is further challenged by a lack of good biomarkers. We studied the role of novel markers for AKI, neutrophil gelatinase-associated lipocalin (NGAL), interleukin-8 (IL-18), Netrin-1 (NTN-1), and sodium hydrogen exchanger isoform 3 (NHE3) on development and early diagnosis of AKI in newborns with perinatal asphyxia (PA). METHODS: Forty-one newborns with a diagnosis of PA (15 with AKI and 26 without AKI) and 20 healthy matched controls were involved to the study...
July 2016: Renal Failure
https://www.readbyqxmd.com/read/26977258/pyruvate-kinase-m2-a-novel-biomarker-for-the-early-detection-of-acute-kidney-injury
#8
Ji Hyun Cheon, Sun Young Kim, Ji Yeon Son, Ye Rim Kang, Ji Hye An, Ji Hoon Kwon, Ho Sub Song, Aree Moon, Byung Mu Lee, Hyung Sik Kim
The identification of biomarkers for the early detection of acute kidney injury (AKI) is clinically important. Acute kidney injury (AKI) in critically ill patients is closely associated with increased morbidity and mortality. Conventional biomarkers, such as serum creatinine (SCr) and blood urea nitrogen (BUN), are frequently used to diagnose AKI. However, these biomarkers increase only after significant structural damage has occurred. Recent efforts have focused on identification and validation of new noninvasive biomarkers for the early detection of AKI, prior to extensive structural damage...
January 2016: Toxicological Research
https://www.readbyqxmd.com/read/26948834/clinical-use-of-the-urine-biomarker-timp-2-%C3%A2-%C3%A3-igfbp7-for%C3%A2-acute-kidney-injury-risk-assessment
#9
Anitha Vijayan, Sarah Faubel, David J Askenazi, Jorge Cerda, William H Fissell, Michael Heung, Benjamin D Humphreys, Jay L Koyner, Kathleen D Liu, Girish Mour, Thomas D Nolin, Azra Bihorac
Acute kidney injury (AKI) is a serious complication, commonly occurring in the critically ill population, with devastating short- and long-term consequences. Despite standardization of the definition and staging of AKI, early recognition remains challenging given that serum creatinine level is a marker, albeit imperfect, of kidney function and not kidney injury. Furthermore, the delay in increase in serum creatinine level after loss of glomerular filtration also prevents timely detection of decreased kidney function in patients with AKI...
July 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26860999/evaluation-of-novel-biomarkers-of-acute-kidney-injury-the-possibilities-and-limitations
#10
Branislava Medić, Branislav Rovcanin, Katarina Savic Vujovic, Danilo Obradovic, Dusan Duric, Milica Prostran
Despite the recent findings concerning pathogenesis and novel therapeutic strategies, the mortality rate in patients with acute kidney injury (AKI) remains very high. Early detection of patients with impaired renal function may help to ensure more aggresive treatment and to improve clinical outcome. Serum creatinine is still gold standard of kidney injury, although it is well known as an insensitive and unreliable biomarker (for example, its concentration does not increase significantly until about half of the kidney function is lost)...
2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/26629810/neutrophil-gelatinase-associated-lipocalin-ngal-in-leptospirosis-acute-kidney-injury-a-multicenter-study-in-thailand
#11
MULTICENTER STUDY
Nattachai Srisawat, Kearkiat Praditpornsilpa, Kanitha Patarakul, Malee Techapornrung, Tinnapop Daraswang, Theerapon Sukmark, Kamol Khositrangsikun, Apinya Fakthongyoo, Petchdee Oranrigsupak, Laksamon Praderm, Ummarit Suwattanasilpa, Sadudee Peerapornratana, Passisd Loahaveeravat, Nattachai Suwachittanont, Thaksa-on Wirotwan, Chayanat Phonork, Sarinya Kumpunya, Khajohn Tiranathanagul, Chintana Chirathaworn, Somchai Eiam-ong, Kriang Tungsanga, Visith Sitprija, John A Kellum, Natavudh Townamchai
AKI is one of the most serious complications of leptospirosis, an important zoonosis in the tropics. Recently, NGAL, one of the novel AKI biomarkers, is extensively studied in various specific settings such as sepsis, cardiac surgery, and radiocontrast nephropathy. In this multicenter study, we aimed to study the role of NGAL as an early marker and an outcome predictor of leptospirosis associated AKI. Patients who presented with clinical suspiciousness of leptospirosis were prospectively enrolled in 9 centers from August 2012 to November 2014...
2015: PloS One
https://www.readbyqxmd.com/read/26628795/the-role-of-neutrophil-gelatinase-associated-lipocalin-in-early-diagnosis-of-contrast-nephropathy
#12
M R Khatami, M R P Sabbagh, N Nikravan, Z Khazaeipour, M A Boroumand, S Sadeghian, B Davoudi
Neutrophil-gelatinase-associated lipocalin (NGAL) is a biomarker of acute kidney injury. The aim of this study was to define a cut-off for NGAL in the early diagnosis of contrast-induced nephropathy (CIN) in patients with normal kidney function. We enrolled 121 patients with normal serum creatinine who underwent coronary angiography. NGAL was measured in urine before the procedure and 12 and 24 h afterward. CIN was defined as a 0.3 mg/dl increase in serum creatinine within 48 h after the procedure. Seven of 121 patients had CIN (5...
September 2015: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/26337190/dysregulated-micrornas-involved-in-contrast-induced-acute-kidney-injury-in-rat-and-human
#13
A Gutiérrez-Escolano, E Santacruz-Vázquez, F Gómez-Pérez
BACKGROUND: Contrast-induced nephropathy (CIN) is a complex syndrome of acute nephropathy that occurs following infusion of intravascular contrast agents, and is associated with an increased risk for adverse cardiovascular events. While there is no ideal biomarker for making an early diagnosis of CIN, we hypothesized that levels of specific circulating microRNA (miRNA) species might serve such a role. METHODS: miRNA microarray assays were used to detect miRNAs in the kidney tissue of rats studied as an animal model of CIN...
2015: Renal Failure
https://www.readbyqxmd.com/read/26303800/role-of-urine-neutrophil-gelatinase-associated-lipocalin-in-the-early-diagnosis-of-amphotericin-b-induced-acute-kidney-injury
#14
Paulo Novis Rocha, Michael Nascimento Macedo, Carla Dinamérica Kobayashi, Lis Moreno, Luiz Henrique Santos Guimarães, Paulo Roberto Lima Machado, Roberto Badaró, Edgar M Carvalho, Marshall Jay Glesby
Determination of the neutrophil gelatinase-associated lipocalin (NGAL) level can be used to detect acute kidney injury (AKI) earlier than determination of the serum creatinine (SCr) level in settings such as cardiac surgery, contrast nephropathy, and intensive care units. We hypothesized that urine NGAL (UrNGAL) would be an early biomarker of drug nephrotoxicity. To test this, we studied hemodynamically stable patients treated with amphotericin B (AmB). We measured the SCr and UrNGAL levels at the baseline and daily after initiation of AmB up to day 14 or development of AKI by the use of the SCr criterion...
November 2015: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/26099916/role-of-biomarkers-of-nephrotoxic-acute-kidney-injury-in-deliberate-poisoning-and-envenomation-in-less-developed-countries
#15
REVIEW
Fahim Mohamed, Zoltan H Endre, Nicholas A Buckley
Acute kidney injury (AKI) has diverse causes and is associated with increased mortality and morbidity. In less developed countries (LDC), nephrotoxic AKI (ToxAKI) is common and mainly due to deliberate ingestion of nephrotoxic pesticides, toxic plants or to snake envenomation. ToxAKI shares some pathophysiological pathways with the much more intensively studied ischaemic AKI, but in contrast to ischaemic AKI, most victims are young, previously healthy adults. Diagnosis of AKI is currently based on a rise in serum creatinine...
July 2015: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/26069825/plasma-neutrophil-gelatinase-associated-lipocalin-ngal-as-an-early-predictive-marker-of-contrast-induced-nephropathy-in-hospitalized-patients-undergoing-computed-tomography
#16
Vassilis Filiopoulos, Dimitra Biblaki, Dimitrios Lazarou, Dimitrios Chrisis, Mavra Fatourou, Sofia Lafoyianni, Dimosthenis Vlassopoulos
BACKGROUND: Contrast-induced nephropathy (CIN) is a common cause of hospital-acquired acute kidney injury (AKI). Neutrophil gelatinase-associated lipocalin (NGAL) represents a promising biomarker for AKI. Its role in the early diagnosis of CIN has already been examined in adults and children undergoing coronary angiography. This study was designed to prospectively evaluate plasma NGAL compared with serum creatinine (SCr) for early CIN detection among hospitalized patients undergoing contrast-enhanced computed tomography (CT)...
December 2013: Clinical Kidney Journal
https://www.readbyqxmd.com/read/25845505/acute-kidney-injury-in-severe-sepsis-pathophysiology-diagnosis-and-treatment-recommendations
#17
REVIEW
Iain Keir, John A Kellum
OBJECTIVE: To review the unique pathophysiology of sepsis-induced acute kidney injury (AKI) and highlight the relevant aspects of the Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline for Acute Kidney Injury that may apply to veterinary patients. DATA SOURCES: Electronic search of MEDLINE database. HUMAN DATA SYNTHESIS: Sepsis-induced AKI is diagnosed in up to 47% of human ICU patients and is seen as a major public health concern associated with increased mortality and increased progression to chronic kidney disease (CKD)...
March 2015: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/25684463/predictive-role-of-neutrophil-gelatinase-associated-lipocalin-in-early-diagnosis-of-platin-induced-renal-injury
#18
Mehmet Metin Seker, Koksal Deveci, Ayse Seker, Enver Sancakdar, Ali Yilmaz, A Kerim Turesin, Turgut Kacan, Nalan A Babacan
BACKGROUND: Acute kidney injury is an important issue in chemotherapy receiving patients an neutrophil gelatinase-associated lipocalin has been proposed as a novel marker. We here aimed to assess the role of urinary levels for assessment after platin exposure. MATERIALS AND METHODS: Patients who had treated with cisplatin or carboplatin or oxaliplatin containg regimens were included in this study. Baseline and postchemotherapy serum urea, creatinine, urine neutrophil gelatinase-associated lipocalin and urine creatinine levels were determined...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/25392341/the-dose-related-effects-of-dexmedetomidine-on-renal-functions-and-serum-neutrophil-gelatinase-associated-lipocalin-values-after-coronary-artery-bypass-grafting-a-randomized-triple-blind-placebo-controlled-study
#19
RANDOMIZED CONTROLLED TRIAL
Ozan Onur Balkanay, Deniz Goksedef, Suat Nail Omeroglu, Gokhan Ipek
OBJECTIVES: Acute kidney failure after coronary artery bypass grafting (CABG) is a serious complication that increases morbidity and mortality rates. Early detection and prevention of this complication are very important. A novel biomarker named neutrophil gelatinase-associated lipocalin (NGAL) can play an important role in early diagnosis of acute kidney injury. Recent studies on the favourable effects of Dexmedetomidine on cardiac surgery have been published. The aim of this study is to investigate whether there is a dose-dependent positive effect of Dexmedetomidine on neutrophil gelatinase-associated lipocalin levels and renal functions when used after CABG...
February 2015: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/25343847/repair-or-progression-after-aki-a-role-for-biomarkers
#20
REVIEW
Nattachai Srisawat, Raghavan Murugan, John A Kellum
Recent progress in biomarkers represents a paradigm shift in acute kidney injury (AKI) research. Most studies have evaluated the use of these biomarkers for early diagnosis of AKI. However, the role of novel biomarkers in predicting renal recovery, though less understood, holds great clinical promise. Accurate prediction would help physicians distinguish patients with poor renal prognosis in whom further therapy is unlikely to be useful from those who are likely to have good renal prognosis. Unfortunately, current general clinical severity scores (APACHE, SOFA, etc...
2014: Nephron. Clinical Practice
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