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JOURNAL ARTICLE
Alessio Alogna, Leonhard Berboth, Alessandro Faragli, Jens Ötvös, Francesco Paolo Lo Muzio, Vittoria di Mauro, Jessica Modica, Eride Quarta, Lukas Semmler, Peter Maximilian Deißler, Yannic Wanja Berger, Khai Liem Tran, Beatrice de Marchi, Gianluigi Longinotti-Buitoni, Lorenzo Degli Esposti, Etienne Guillot, Didier Bazile, Michele Iafisco, Alessandro Dotti, Marie-Louise Bang, Claudio de Luca, Christina Brandenberger, Louise Benazzi, Dario di Silvestre, Antonella de Palma, Uwe Primeßnig, Felix Hohendanner, Simone Perna, Francesca Buttini, Paolo Colombo, Christian Mühlfeld, Paul Steendijk, Pierluigi Mauri, Carsten Tschöpe, Barry Borlaug, Burkert M Pieske, Philipp Attanasio, Heiner Post, Frank R Heinzel, Daniele Catalucci
BACKGROUND: The lack of disease-modifying drugs is one of the major unmet needs in patients with heart failure (HF). Peptides are highly selective molecules with the potential to act directly on cardiomyocytes. However, a strategy for effective delivery of therapeutics to the heart is lacking. OBJECTIVES: In this study, the authors sought to assess tolerability and efficacy of an inhalable lung-to-heart nano-in-micro technology (LungToHeartNIM) for cardiac-specific targeting of a mimetic peptide (MP), a first-in-class for modulating impaired L-type calcium channel (LTCC) trafficking, in a clinically relevant porcine model of HF...
January 2, 2024: Journal of the American College of Cardiology
#22
JOURNAL ARTICLE
Leonardo Colombo, Giovanni Montesano, Alice Di Domenico, Benedetta Colizzi, Roberta Rissotto, Paolo Maltese, Matteo Bertelli, Alessandro Autelitano, Luca Rossetti
PURPOSE: To compare within-subject efficacy and safety of intravitreal dexamethasone implant (IVDI) and topical carbonic anhydrase inhibitors (CAI) in the treatment of retinitis pigmentosa (RP)-related cystoid macular edema (CME). METHODS: Patients with bilateral RP-related CME were treated with IVDI in one eye and topical CAIs in the contralateral eye. The primary endpoint was a change in central macular thickness (CMT). Secondary endpoints were changes in BCVA and microperimetric central retinal sensitivity...
January 2, 2024: Retina
#23
JOURNAL ARTICLE
Michael Kirschner, Veli K Topkara, Jocelyn Sun, Paul Kurlansky, Yuji Kaku, Yoshifumi Naka, Melana Yuzefpolskaya, Paolo C Colombo, Gabriel Sayer, Nir Uriel, Koji Takeda
OBJECTIVE: To compare 3-year survival and readmissions of patients who received the HeartMate 3 (HM3) left ventricular assist device (LVAD) or underwent orthotopic heart transplantation (OHT) as primary treatment for advanced heart failure. METHODS: We retrospectively analyzed 381 adult patients who received an HM3 LVAD or were listed for OHT between January 2014 and March 2021 at our center. To minimize crossover bias, OHT recipients with a prior LVAD were excluded, and HM3 patients were censored at the time of transplant...
December 27, 2023: Journal of Thoracic and Cardiovascular Surgery
#24
JOURNAL ARTICLE
Angelo Oliva, Antonio Mangieri, Ottavia Cozzi, Renato Bragato, Alessandro Sticchi, Letizia Bertoldi, Federico De Marco, Lorenzo Monti, Paolo Tosi, Giancarlo Vitrella, Lucia Torracca, Bernhard Reimers, Antonio Colombo, Damiano Regazzoli
No abstract text is available yet for this article.
December 20, 2023: JACC. Cardiovascular Interventions
#25
JOURNAL ARTICLE
Cristina Panico, Arianna Felicetta, Paolo Kunderfranco, Marco Cremonesi, Nicolò Salvarani, Pierluigi Carullo, Federico Colombo, Alessandra Idini, Mauro Passaretti, Riccardo Doro, Marcello Rubino, Alessandro Villaschi, Giorgio Da Rin, Clelia Peano, Marinos Kallikourdis, Carolina M Greco, Gianluigi Condorelli
BACKGROUND: Metabolic distress is often associated with heart failure with preserved ejection fraction (HFpEF) and represents a therapeutic challenge. Metabolism-induced systemic inflammation links comorbidities with HFpEF. How metabolic changes affect myocardial inflammation in the context of HFpEF is not known. METHODS: We found that ApoE knockout mice fed a Western diet recapitulate many features of HFpEF. Single-cell RNA sequencing was used for expression analysis of CD45+ cardiac cells to evaluate the involvement of inflammation in diastolic dysfunction...
December 21, 2023: Circulation
#26
JOURNAL ARTICLE
Luca Piacentini, Veronika A Myasoedova, Mattia Chiesa, Chiara Vavassori, Donato Moschetta, Vincenza Valerio, Gloria Giovanetti, Ilaria Massaiu, Nicola Cosentino, Giancarlo Marenzi, Paolo Poggio, Gualtiero I Colombo
BACKGROUND: Aortic valve sclerosis (AVSc) presents similar pathogenetic mechanisms to coronary artery disease and is associated with short- and long-term mortality in patients with coronary artery disease. Evidence of AVSc-specific pathophysiological traits in acute myocardial infarction (AMI) is currently lacking. Thus, we aimed to identify a blood-based transcriptional signature that could differentiate AVSc from non-AVSc patients during AMI. METHODS: Whole-blood transcriptome of AVSc (n=44) and no-AVSc (n=66) patients with AMI was assessed by RNA sequencing on hospital admission...
December 21, 2023: Arteriosclerosis, Thrombosis, and Vascular Biology
#27
JOURNAL ARTICLE
Barbara Poletti, Edoardo Nicolò Aiello, Sofia Tagini, Federica Solca, Silvia Torre, Eleonora Colombo, Alessio Maranzano, Ruggero Bonetti, Francesco Schevegher, Claudia Morelli, Alberto Doretti, Federico Verde, Sergio Barbieri, Francesca Mameli, Alberto Priori, Roberta Ferrucci, Vincenzo Silani, Paolo Cherubini, Gabriella Pravettoni, Nicola Ticozzi
OBJECTIVES: This study aimed at exploring (1) the motor and non-motor correlates of counterfactual thinking (CFT) abilities in non-demented amyotrophic lateral sclerosis (ALS) patients and (2) the ability of CFT measures to discriminate these patients from healthy controls (HCs) and patients with and without cognitive impairment. METHODS: N = 110 ALS patients and N = 51 HCs were administered two CFT tasks, whose sum, resulting in a CFT Index (CFTI), was addressed as the outcome...
2023: Frontiers in Psychology
#28
JOURNAL ARTICLE
Jaya Batra, Ersilia M DeFilippis, Kevin Clerkin, David Bae, Kyung Taek Oh, Dor Lotan, Veli K Topkara, Sun Hi Lee, Farhana Latif, Paolo Colombo, Melana Yuzefpolskaya, Jayant Raikhelkar, David T Majure, Gabriel Sayer, Nir Uriel
BACKGROUND: Among heart transplant (HT) recipients who develop advanced graft dysfunction, cardiac re-transplantation may be considered. A smaller subset of patients will experience failure of their second allograft and undergo repeat re-transplantation. Outcomes among these individuals are not well-described. METHODS: Adult and pediatric patients in the United Network for Organ Sharing (UNOS) registry who received HT between January 1, 1990 and December 31, 2020 were included...
December 11, 2023: Clinical Transplantation
#29
JOURNAL ARTICLE
Hideyuki Hayashi, Michael Kirschner, Alice Vinogradsky, Yuming Ning, Paul Kurlansky, Melana Yuzefpolskaya, Paolo C Colombo, Gabriel T Sayer, Nir Uriel, Yoshifumi Naka, Koji Takeda
BACKGROUND: The physiological response of the right ventricle (RV) following left ventricular assist device (LVAD) implantation is difficult to predict. We aimed to investigate RV geometric and functional changes after LVAD insertion and their effects on clinical outcomes. METHODS: We retrospectively reviewed 188 patients who underwent HeartMate 3 implantation at our center between November 2014 and September 2021. The RV end-diastolic diameter (RVEDD) and area (RVEDA) were measured on preoperative and pre-discharge transthoracic echocardiography...
December 7, 2023: Journal of Heart and Lung Transplantation
#30
JOURNAL ARTICLE
Gabriele Bonetti, William Cozza, Andrea Bernini, Jurgen Kaftalli, Chiara Mareso, Francesca Cristofoli, Maria Chiara Medori, Leonardo Colombo, Salvatore Martella, Giovanni Staurenghi, Anna Paola Salvetti, Benedetto Falsini, Giorgio Placidi, Marcella Attanasio, Grazia Pertile, Mario Bengala, Francesca Bosello, Antonio Petracca, Fabiana D'Esposito, Benedetta Toschi, Paolo Lanzetta, Federico Ricci, Francesco Viola, Giuseppe Marceddu, Matteo Bertelli
Sequencing of the low-complexity ORF15 exon of RPGR, a gene correlated with retinitis pigmentosa and cone dystrophy, is difficult to achieve with NGS and Sanger sequencing. False results could lead to the inaccurate annotation of genetic variants in dbSNP and ClinVar databases, tools on which HGMD and Ensembl rely, finally resulting in incorrect genetic variants interpretation. This paper aims to propose PacBio sequencing as a feasible method to correctly detect genetic variants in low-complexity regions, such as the ORF15 exon of RPGR, and interpret their pathogenicity by structural studies...
November 28, 2023: International Journal of Molecular Sciences
#31
JOURNAL ARTICLE
Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch-Ernst, Alexandre Maciuk, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Margarita Aguilera-Gómez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Miguel Prieto Maradona, Rosangela Marchelli, Monika Neuhäuser-Berthold, Carmen Peláez, Morten Poulsen, Josef Rudolf Schlatter, Alexandros Siskos, Henk van Loveren, Paolo Colombo, Estefanía Noriega Fernández, Helle Katrine Knutsen
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on lacto-N-fucopentaose I (LNFP-I)/2'-fucosyllactose (2'-FL) mixture as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF is mainly composed of the human-identical milk oligosaccharides (HiMO) LNFP-I and 2'-FL, but it also contains d-lactose, lacto-N-tetraose, difucosyllactose, 3-fucosyllactose, LNFP-I fructose isomer, 2'-fucosyl-d-lactulose, l-fucose and 2'-fucosyl-d-lactitol, and a small fraction of other related saccharides...
December 2023: EFSA journal
#32
JOURNAL ARTICLE
Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch-Ernst, Alexandre Maciuk, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Margarita Aguilera-Gómez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Miguel Prieto Maradona, Rosangela Marchelli, Monika Neuhäuser-Berthold, Carmen Peláez, Morten Poulsen, Josef Rudolf Schlatter, Alexandros Siskos, Henk van Loveren, Paolo Colombo, Estefanía Noriega Fernández, Helle Katrine Knutsen
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on 2'-fucosyllactose (2'-FL) as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF is mainly composed of the human-identical milk oligosaccharide (HiMO) 2'-FL, but it also contains d-lactose, l-fucose, fucosylgalactose, difucosyllactose, d-glucose and d-galactose, and a small fraction of other related saccharides. The NF is produced by fermentation by a genetically modified strain ( Escherichia coli SGR5) of E...
November 2023: EFSA journal
#33
JOURNAL ARTICLE
Bianca Barletta, Silvia Corinti, Francesca Maranghi, Sabrina Tait, Roberta Tassinari, Andrea Martinelli, Alessandra Longo, Valeria Longo, Paolo Colombo, Gabriella Di Felice, Cinzia Butteroni
2,2',4,4'-tetra-bromodiphenyl ether (BDE-47) is widespread in the environment and biological samples. Its association with health risks is an increasing concern, yet information on BDE-47 immunotoxicity remains limited. This study investigated the impact of BDE-47 on innate and adaptive immune responses through in vitro and in vivo approaches. BDE-47's capacity to directly induce cell responses and modulate responses induced by known stimuli was studied in vitro using the RAW 264.7 murine macrophage cell line and spleen-derived lymphocytes, and in vivo using keyhole limpet hemocyanin (KLH)-immunized BALB/c mice orally administered (28 d) at dose levels (7...
November 22, 2023: Chemosphere
#34
JOURNAL ARTICLE
Eugenia D'Atanasio, Flavia Risi, Francesco Ravasini, Francesco Montinaro, Mogge Hajiesmaeil, Biancamaria Bonucci, Letizia Pistacchia, Daniel Amoako-Sakyi, Maria Bonito, Sara Onidi, Giulia Colombo, Ornella Semino, Giovanni Destro Bisol, Paolo Anagnostou, Mait Metspalu, Kristiina Tambets, Beniamino Trombetta, Fulvio Cruciani
The population history of the Sahara/Sahelian belt is understudied, despite previous work highlighting complex dynamics.1 , 2 , 3 , 4 , 5 , 6 , 7 The Sahelian Fulani, i.e., the largest nomadic pastoral population in the world,8 represent an interesting case because they show a non-negligible proportion of an Eurasian genetic component, usually explained by recent admixture with northern Africans.1 , 2 , 5 , 6 , 7 , 9 , 10 , 11 , 12 Nevertheless, their origins are largely unknown, although several hypotheses have been proposed, including a possible link to ancient peoples settled in the Sahara during its last humid phase (Green Sahara, 12,000-5,000 years before present [BP])...
November 14, 2023: Current Biology: CB
#35
JOURNAL ARTICLE
Lusha W Liang, Annamaria Ladanyi, Peter J Kennel, Kelly M Axsom, Gabriel T Sayer, Koji Takeda, Miroslav Sekulic, Nir Uriel, Stavros Drakos, Paolo C Colombo, Melana Yuzefpolskaya
Despite advances in our understanding of myocardial recovery among left ventricular assist device (LVAD) patients, with 10-30% of patients achieving substantial myocardial improvement, the rates of LVAD support cessation remain extremely low (1-2%). These numbers are in stark contrast to clinical trial data where successful LVAD cessation is reported in up to 47% of patients. The majority of LVAD programs lack structured recovery programs and targeted protocols, likely underscoring the heterogeneity that exists among LVAD patients with myocardial recovery...
November 14, 2023: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
#36
JOURNAL ARTICLE
Sabrina Banella, Aishwarya Saraswat, Akanksha Patel, Abu T M Serajuddin, Paolo Colombo, Ketan Patel, Gaia Colombo
Loco-regional chemotherapy is a strategy used to achieve more precise anticancer drug effect directly on tumor mass, while decreasing whole body exposure, which can lead to undesirable side effects. Thus, the loco-regional chemotherapy is conceptually similar to the targeted drug delivery systems for delivering chemotherapeutics to cancer cells in a certain location of the body. Recently, it has been demonstrated that a novel polymeric film containing the complex between cisplatin (cisPt) and hyaluronan (sodium salt of hyaluronic acid; NaHA) enhanced in vivo efficacy and safety of cisplatin (cisPt) by loco-regional delivery in pleural mesothelioma...
October 29, 2023: International Journal of Molecular Sciences
#37
JOURNAL ARTICLE
Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch-Ernst, Alexandre Maciuk, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Margarita Aguilera-Gómez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Miguel Prieto Maradona, Rosangela Marchelli, Monika Neuhäuser-Berthold, Carmen Peláez, Morten Poulsen, Josef Rudolf Schlatter, Alexandros Siskos, Henk van Loveren, Paolo Colombo, Estefanía Noriega Fernández, Helle Katrine Knutsen
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the safety of the extension of use of 2'-fucosyllactose (2'-FL) as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF is already authorised as ingredient in several food categories, including infant formula (IF) and follow-on formula (FOF). The applicant proposed to increase the maximum use levels of the NF in IF and FOF. EFSA estimated the anticipated daily intake of the NF from the proposed extension of use, including the already authorised conditions of use in other food categories...
November 2023: EFSA journal
#38
Mara Colombo, Patrizia Mondini, Elisa Minenza, Claudia Foglia, Annamaria Mosconi, Carmen Molica, Lorenza Pistola, Vienna Ludovini, Paolo Radice
[This corrects the article DOI: 10.3389/fonc.2023.1102184.].
2023: Frontiers in Oncology
#39
JOURNAL ARTICLE
Daniel Oren, Cathrine M Moeller, Jennifer H Haythe, Gal Rubinstein, Andrea Fernandez Valledor, Dor Lotan, Hannah Rosenblum, Paolo C Colombo, Melana Yuzefpolskaya, Veli K Topkara, Kevin J Clerkin, Jayant K Raikhelkar, Justin A Fried, Yoshifumi Naka, Koji Takeda, Farhana Latif, Gabriel Sayer, Nir Uriel
This review discusses the challenges and outcomes associated with pregnancy during left ventricular assist device (LVAD) support. Women account for a third of the heart failure population in the United States. Left ventricular assist devices have emerged as a safe and effective treatment option for patients with advanced heart failure. Pregnancy during LVAD support can occur, and it presents significant risks to both mother and fetus, including hemodynamic stress, thrombotic events, medication-associated teratogenicity, and uterine impingement...
November 7, 2023: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
#40
JOURNAL ARTICLE
Sara Cupini, Stefano Di Marco, Luca Boselli, Alessio Cavalli, Giulia Tarricone, Valentina Mastronardi, Valentina Castagnola, Elisabetta Colombo, Pier Paolo Pompa, Fabio Benfenati
Degeneration of photoreceptors in age-related macular degeneration (AMD) is associated with oxidative stress due to the intense aerobic metabolism of rods and cones that if not properly counterbalanced by endogenous antioxidant mechanisms can precipitate photoreceptor degeneration. In spite of being a priority eye disease for its high incidence in the elderly, no effective treatments for AMD exist. While systemic administration of antioxidants has been unsuccessful in slowing down degeneration, locally administered rare-earth nanoparticles were shown to be effective in preventing retinal photo-oxidative damage...
November 28, 2023: ACS Nano
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