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https://www.readbyqxmd.com/read/27916323/donor-specific-anti-hla-antibodies-with-antibody-mediated-rejection-and-long-term-outcomes-following-heart-transplantation
#1
Kevin J Clerkin, Maryjane A Farr, Susan W Restaino, Emmanuel Zorn, Farhana Latif, Elena R Vasilescu, Charles C Marboe, Paolo C Colombo, Donna M Mancini
BACKGROUND: Donor-specific anti-HLA antibodies (DSA) are common after heart transplantation and are associated with rejection, cardiac allograft vasculopathy, and mortality. A noninvasive diagnostic test for pathologic antibody-mediated rejection (pAMR) does not exist. METHODS: From January 1, 2010, through August 31, 2013, 221 consecutive adult patients underwent heart transplantation and were followed through October 1, 2015. The primary objective was to determine whether the presence of DSA could detect AMR at the time of pathologic diagnosis...
November 17, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27880704/voluntary-home-smoking-ban-prevalence-trend-and-determinants-in-italy
#2
Silvano Gallus, Alessandra Lugo, Giuseppe Gorini, Paolo Colombo, Roberta Pacifici, Esteve Fernandez
To investigate voluntary home smoking bans, we analysed five nationally representative surveys on 15 175 adults conducted in Italy in 2011-2015. Overall, 61% of Italians (69% of non-smokers and 32% of current smokers) adopted a complete home smoking ban. Although families with children more frequently live in smoke-free homes, still the majority of current smokers living with children admit smoking inside their homes. Complete home smoking bans are substantially increasing in Italy, and an acceleration of this trend is expected with the 2016 implementation of a new tobacco control legislation aimed at decreasing the social acceptability of smoking...
October 2016: European Journal of Public Health
https://www.readbyqxmd.com/read/27844161/latent-classes-of-emotional-and-behavioural-problems-in-epidemiological-and-referred-samples-and-their-relations-to-dsm-iv-diagnoses
#3
Valentina Bianchi, Paolo Brambilla, Marco Garzitto, Paola Colombo, Livia Fornasari, Monica Bellina, Carolina Bonivento, Alessandra Tesei, Sara Piccin, Stefania Conte, Giampaolo Perna, Alessandra Frigerio, Isabella Castiglioni, Franco Fabbro, Massimo Molteni, Maria Nobile
Researchers' interest have recently moved toward the identification of recurrent psychopathological profiles characterized by concurrent elevations on different behavioural and emotional traits. This new strategy turned to be useful in terms of diagnosis and outcome prediction. We used a person-centred statistical approach to examine whether different groups could be identified in a referred sample and in a general-population sample of children and adolescents, and we investigated their relation to DSM-IV diagnoses...
November 14, 2016: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/27818380/novel-minimally-invasive-surgical-approach-using-an-external-ventricular-assist-device-and-extracorporeal-membrane-oxygenation-in-refractory-cardiogenic-shock
#4
Koji Takeda, Arthur R Garan, Veli K Topkara, Ajay J Kirtane, Dimitri Karmpaliotis, Paul Kurlansky, Melana Yuzefpolskaya, Paolo C Colombo, Yoshifumi Naka, Hiroo Takayama
OBJECTIVES: The use of short-term mechanical circulatory support (MCS) has increased in the treatment of refractory cardiogenic shock (RCS). Percutaneous short-term MCS technology has emerged rapidly; however, limitations in flow and durability remain. We therefore investigated a minimally invasive surgical approach using an external ventricular assist device (VAD) and extracorporeal membrane oxygenation (ECMO) in patients with RCS. METHODS: Twenty-five patients underwent minimally invasive external VAD insertion with a magnetically levitated centrifugal pump for various causes of cardiogenic shock between April 2010 and May 2016...
November 6, 2016: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/27809498/theranostic-nanocages-for-imaging-and-photothermal-therapy-of-prostate-cancer-cells-by-active-targeting-of-neuropeptide-y-receptor
#5
Svetlana Avvakumova, Elisabetta Galbiati, Laura Sironi, Silvia A Locarno, Luca Gambini, Chiara Macchi, Laura Pandolfi, Massimiliano Ruscica, Paolo Magni, Maddalena Collini, Miriam Colombo, Fabio Corsi, Giuseppe Chirico, Sergio Romeo, Davide Prosperi
Gold nanocages (AuNCs) have been shown to be a useful tool for harnessing imaging and hyperthermia therapy of cancer, thanks to their unique optical properties, low toxicity and facile surface functionalization. Herein, we use AuNCs for selective targeting of prostate cancer cells (PC3) via specific interaction between neuropeptide Y (NPY) receptor and three different NPY analogs conjugated to AuNCs. Localized surface plasmon band of the nanoconjugates was set around 800 nm, which is appropriate for in vivo applications...
November 3, 2016: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/27797918/european-crohn-s-and-colitis-organisation-topical-review-on-ibd-in-the-elderly
#6
Andreas Sturm, Christian Maaser, Michael Mendall, Dimitrios Karagiannis, Pantelis Karatzas, Nienke Ipenburg, Shaji Sebastian, Fernando Rizzello, Jimmy Limdi, Konstantinos Katsanos, Carsten Schmidt, Steven Jeuring, Francesco Colombo, Paolo Gionchetti
This ECCO topical review of the European Crohn's and Colitis Organisation [ECCO] focuses on the epidemiology, pathophysiology, diagnosis, management and outcome of the two most common forms of inflammatory bowel disease, Crohn's disease and ulcerative colitis, in elderly patients. The objective was to reach expert consensus to provide evidence-based guidance for clinical practice.
October 20, 2016: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/27773451/discriminatory-performance-of-positive-urine-hemoglobin-for-detection-of-significant-hemolysis-in-patients-with-continuous-flow-left-ventricular-assist-devices
#7
Michael V Gavalas, Alexander Breskin, Melana Yuzefpolskaya, Andrew Eisenberger, Francesco Castagna, Ryan T Demmer, Margaret Flannery, A Reshad Garan, Koji Takeda, Hiroo Takayama, Yoshifumi Naka, Veli K Topkara, Paolo C Colombo
BACKGROUND: Serum lactate dehydrogenase (LDH) is the standard measure for detection of hemolysis and thus surveillance for device thrombosis in patients on continuous-flow left ventricular assist device (CF-LVAD) support. Significant hemolysis has been defined as LDH ≥600 IU/L. However, LDH testing requires phlebotomy, precluding frequent home monitoring. Simple dipstick urinalysis (UA) for urine hemoglobin (U-Hb) overcomes this limitation. This study correlated U-Hb and LDH levels and evaluated the performance of UA for detection of significant hemolysis in patients with CF-LVADs...
September 13, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27758810/impact-of-socioeconomic-status-on-patients-supported-with-a-left-ventricular-assist-device-an-analysis-of-the-unos-database-united-network-for-organ-sharing
#8
Kevin J Clerkin, Arthur Reshad Garan, Brian Wayda, Raymond C Givens, Melana Yuzefpolskaya, Shunichi Nakagawa, Koji Takeda, Hiroo Takayama, Yoshifumi Naka, Donna M Mancini, Paolo C Colombo, Veli K Topkara
BACKGROUND: Low socioeconomic status (SES) is a known risk factor for heart failure, mortality among those with heart failure, and poor post heart transplant (HT) outcomes. This study sought to determine whether SES is associated with decreased waitlist survival while on left ventricular assist device (LVADs) support and after HT. METHODS AND RESULTS: A total of 3361 adult patients bridged to primary HT with an LVAD between May 2004 and April 2014 were identified in the UNOS database (United Network for Organ Sharing)...
October 2016: Circulation. Heart Failure
https://www.readbyqxmd.com/read/27752795/percutaneous-bicuspidalization-of-the-tricuspid-valve-using-the-mitraclip-system
#9
Azeem Latib, Antonio Mangieri, Eustachio Agricola, Paolo Denti, Damiano Regazzoli, Francesco Giannini, Marco B Ancona, Fabrizio Monaco, Ottavio Alfieri, Antonio Colombo
An 84-year-old man with cardial senile amyloidosis and severe tricuspid regurgitation was referred for right sided heart failure symptoms. The patient was scheduled for a percutaneous treatment due to the prohibitive risk of surgery. Two MitraClips were implanted using a transjugular approach with successful echocardiographic and clinical results. This case shows the rational of the procedural with a bicuspidalization of the valve demonstrated at the three dimensional transesophageal echocardiography.
October 17, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27725939/partially-purified-extracts-of-sea-anemone-anemonia-viridis-affect-the-growth-and-viability-of-selected-tumour-cell-lines
#10
Matteo Bulati, Alessandra Longo, Tiziana Masullo, Sara Vlah, Carmelo Bennici, Angela Bonura, Monica Salamone, Marcello Tagliavia, Aldo Nicosia, Salvatore Mazzola, Paolo Colombo, Angela Cuttitta
In the last few years, marine species have been investigated for the presence of natural products with anticancer activity. Using reversed phase chromatography, low molecular weight proteins were fractionated from the sea anemone Anemonia viridis. Four different fractions were evaluated for their cytotoxic activity by means of erythrocyte haemolysis test, MTS, and LDH assays. Finally, the antiproliferative activities of three of these fractions were studied on PC3, PLC/PRF/5, and A375 human cancer cell lines...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27717917/comparison-of-breaking-tests-for-the-characterization-of-the-interfacial-strength-of-bilayer-tablets
#11
Luca Castrati, Vincent Mazel, Virginie Busignies, Harona Diarra, Alessandra Rossi, Paolo Colombo, Pierre Tchoreloff
The bilayer tableting technology is gaining more acceptance in the drug industry, due to its ability to improve the drug delivery strategies. It is currently assessed by the European Pharmacopoeia, that the mechanical strength of tablets can be evaluated using a diametral breaking tester. This device applies a force diametrically, and records the tablet breaking point. This approach has been used to measure the structural integrity of single layer tablets as well as bilayer (and multi-layer) tablets. The latter ones, however, have a much complex structure...
October 4, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27713755/gun1-a-jack-of-all-trades-in-chloroplast-protein-homeostasis-and-signaling
#12
Monica Colombo, Luca Tadini, Carlotta Peracchio, Roberto Ferrari, Paolo Pesaresi
The GENOMES UNCOUPLED 1 (GUN1) gene has been reported to encode a chloroplast-localized pentatricopeptide-repeat protein, which acts to integrate multiple indicators of plastid developmental stage and altered plastid function, as part of chloroplast-to-nucleus retrograde communication. However, the molecular mechanisms underlying signal integration by GUN1 have remained elusive, up until the recent identification of a set of GUN1-interacting proteins, by co-immunoprecipitation and mass-spectrometric analyses, as well as protein-protein interaction assays...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27649505/new-setting-of-neurally-adjusted-ventilatory-assist-during-noninvasive-ventilation-through-a-helmet
#13
Gianmaria Cammarota, Federico Longhini, Raffaella Perucca, Chiara Ronco, Davide Colombo, Antonio Messina, Rosanna Vaschetto, Paolo Navalesi
BACKGROUND: Compared to pneumatically controlled pressure support (PSP), neurally adjusted ventilatory assist (NAVA) was proved to improve patient-ventilator interactions, while not affecting comfort, diaphragm electrical activity (EAdi), and arterial blood gases (ABGs). This study compares neurally controlled pressure support (PSN) with PSP and NAVA, delivered through two different helmets, in hypoxemic patients receiving noninvasive ventilation for prevention of extubation failure. METHODS: Fifteen patients underwent three (PSP, NAVA, and PSN) 30-min trials in random order with both helmets...
September 19, 2016: Anesthesiology
https://www.readbyqxmd.com/read/27639776/the-efficacy-of-bcg-tice-and-bcg-connaught-in-a-cohort-of-2-099-patients-with-t1g3-non-muscle-invasive-bladder-cancer
#14
J Alfred Witjes, Guido Dalbagni, Robert J Karnes, Shahrokh Shariat, Steven Joniau, Joan Palou, Vincenzo Serretta, Stéphane Larré, Savino di Stasi, Renzo Colombo, Marek Babjuk, Per-Uno Malmström, Nuria Malats, Jacques Irani, Jack Baniel, Tommaso Cai, Eugene Cha, Peter Ardelt, John Varkarakis, Riccardo Bartoletti, Martin Spahn, Francesca Pisano, Paolo Gontero, Richard Sylvester
BACKGROUND: Potential differences in efficacy of different bacillus Calmette-Guérin (BCG) strains are of importance for daily practice, especially in the era of BCG shortage. OBJECTIVE: To retrospectively compare the outcome with BCG Connaught and BCG TICE in a large study cohort of pT1 high-grade non-muscle-invasive bladder cancer patients. DESIGN, SETTING, AND PARTICIPANTS: Individual patient data were collected for 2,451 patients with primary T1G3 tumors from 23 centers who were treated with BCG for the first time between 1990 and 2011...
September 14, 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27630082/poems-syndrome-a-rare-case-report
#15
Benedetta Miglino, Michele Viana, Rossana Tiberio, Paolo Boggio, Guido Valente, Gionata Strigaro, Enrico Colombo
The authors report a case of sensorimotor polyneuropathy, diffuse hemangiomas and monoclonal gammopathy. Besides weight loss, there were diabetes mellitus and severe hypothyroidism. These alterations were consistent with POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy and Skin changes) syndrome, which is a rare systemic disease with monoclonal proliferation of plasmacytes and slow progression. Because of its rarity, the incidence of this disease is still unknown.
September 15, 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/27630080/osteoclastic-like-giant-cells-in-a-cutaneous-squamous-cell-carcinoma
#16
Rossana Tiberio, Benedetta Miglino, Paolo Boggio, Guido Valente, Enrico Colombo
No abstract text is available yet for this article.
September 15, 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/27623768/recovery-of-serum-cholesterol-predicts-survival-after-left-ventricular-assist-device-implantation
#17
Amanda R Vest, Peter J Kennel, Dawn Maldonado, James B Young, Maria M Mountis, Yoshifumi Naka, Paolo C Colombo, Donna M Mancini, Randall C Starling, P Christian Schulze
BACKGROUND: Advanced systolic heart failure is associated with myocardial and systemic metabolic abnormalities, including low levels of total cholesterol and low-density lipoprotein. Low cholesterol and low-density lipoprotein have been associated with greater mortality in heart failure. Implantation of a left ventricular assist device (LVAD) reverses some of the metabolic derangements of advanced heart failure. METHODS AND RESULTS: A cohort was retrospectively assembled from 2 high-volume implantation centers, totaling 295 continuous-flow LVAD recipients with ≥2 cholesterol values available...
September 2016: Circulation. Heart Failure
https://www.readbyqxmd.com/read/27623625/accessorized-dpi-a-shortcut-towards-flexibility-and-patient-adaptability-in-dry-powder-inhalation
#18
Francesca Buttini, James Hannon, Kristi Saavedra, Irene Rossi, Anna Giulia Balducci, Hugh Smyth, Andy Clark, Paolo Colombo
PURPOSE: In this work, a novel powder dispersion add-on device, the AOS (Axial Oscillating Sphere), was studied in conjunction with commercially available DPI devices to improve the powder dispersion. METHODS: An ordered mixture of formoterol fumarate and lactose was selected. We studied in two laboratories located at different altitudes the dispensing and dispersion of the drug at different flow rates, paying particular attention to a number of metrics of Fine Particle Dose (FPD)...
September 13, 2016: Pharmaceutical Research
https://www.readbyqxmd.com/read/27614942/the-impact-of-obesity-on-patients-bridged%C3%A2-to-transplantation-with-continuous-flow-left%C3%A2-ventricular-assist%C3%A2-devices
#19
Kevin J Clerkin, Yoshifumi Naka, Donna M Mancini, Paolo C Colombo, Veli K Topkara
OBJECTIVES: This study sought to determine if obese patients had worse post-left ventricular assist device (LVAD) implantation outcomes and if the implantation of an LVAD allowed for weight loss. BACKGROUND: Obesity is a risk factor for cardiovascular disease including heart failure. Obese heart failure patients have better outcomes than those with normal weight; however, obese patients have worse outcomes after heart transplantation. METHODS: Patients were identified in the United Network for Organ Sharing (UNOS) database that underwent LVAD implantation as bridge to transplantation from May 2004 and April 2014, with follow-up through June 2014...
October 2016: JACC. Heart Failure
https://www.readbyqxmd.com/read/27591255/tail-anchored-protein-insertion-in-mammals-function-and-reciprocal-interactions-of-the-two-subunits-of-the-trc40-receptor
#20
Sara Francesca Colombo, Silvia Cardani, Annalisa Maroli, Adriana Vitiello, Paolo Soffientini, Arianna Crespi, Richard J Bram, Roberta Benfante, Nica Borgese
No abstract text is available yet for this article.
September 2, 2016: Journal of Biological Chemistry
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