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https://www.readbyqxmd.com/read/29141860/multicenter-evaluation-of-octreotide-as-secondary-prophylaxis-in-patients-with-left-ventricular-assist-devices-and-gastrointestinal-bleeding
#1
Keyur B Shah, Sampath Gunda, Sitaramesh Emani, Manreet K Kanwar, Nir Uriel, Paolo C Colombo, Patricia A Uber, Melissa L Sears, Joyce Chuang, David J Farrar, Donald F Brophy, George B Smallfield
BACKGROUND: Gastrointestinal (GI) bleeding is one of the most common complications after continuous-flow left ventricular assist device implantation. More than one third of patients with incident bleed go on to develop recurrent GI bleeding. Octreotide, a somatostatin analog, is proposed to reduce the risk of recurrent GI bleeding in this population. METHODS AND RESULTS: This multicenter, retrospective analysis evaluated 51 continuous-flow left ventricular assist device patients who received secondary prophylaxis with octreotide after their index GI bleed from 2009 to 2015...
November 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29111172/nutritional-counseling-with-or-without-systematic-use-of-oral-nutritional-supplements-in-head-and-neck-cancer-patients-undergoing-radiotherapy
#2
Emanuele Cereda, Silvia Cappello, Sara Colombo, Catherine Klersy, Ilaria Imarisio, Annalisa Turri, Marilisa Caraccia, Valeria Borioli, Teresa Monaco, Marco Benazzo, Paolo Pedrazzoli, Franco Corbella, Riccardo Caccialanza
BACKGROUND: To evaluate the benefit of oral nutritional supplements (ONS) in addition to nutritional counseling in head and neck cancer (HNC) patients undergoing radiotherapy (RT). METHODS: In a single-center, randomized, pragmatic, parallel-group controlled trial (ClinicalTrials.gov: NCT02055833; February 2014-August 2016), 159 newly diagnosed HNC patients suitable for to RT regardless of previous surgery and induction chemotherapy were randomly assigned to nutritional counseling in combination with ONS (N = 78) or without ONS (N = 81) from the start of RT and continuing for up to 3 months after its end...
October 27, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29106559/outcome-of-heart-transplantation-after-bridge-to-transplant-strategy-using-various-mechanical-circulatory-support-devices
#3
Daisuke Yoshioka, Boyangzi Li, Hiroo Takayama, Reshad A Garan, Veli K Topkara, Jiho Han, Paul Kurlansky, Melana Yuzefpolskaya, Paolo C Colombo, Yoshifumi Naka, Koji Takeda
OBJECTIVES: Orthotopic heart transplantation (OHT) is limited by a chronic shortage of donors. With the evolution of technology, more patients have been bridged to transplant (BTT) through various pathways using various types of mechanical circulatory support. We compared short- and long-term outcomes among these various strategies of BTT. METHODS: We retrospectively reviewed 410 patients who had OHT between January 2009 and April 2015. Patients were divided into 4 groups according to BTT status: primary OHT without bridging (Group A, n  = 246); bridge with implantable continuous-flow left ventricular assist device (CF-LVAD) (Group B, n  = 130); bridge with short-term mechanical circulatory support (Group C, n  = 16) and bridge with multiple mechanical circulatory supports, including short-term mechanical circulatory support and CF-LVAD (Group D, n  = 18)...
July 4, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29094607/predictors-of-survival-and-ability-to-wean-from-short-term-mechanical-circulatory-support-device-following-acute-myocardial-infarction-complicated-by-cardiogenic-shock
#4
A Reshad Garan, Christina Eckhardt, Koji Takeda, Veli K Topkara, Kevin Clerkin, Justin Fried, Amirali Masoumi, Ryan T Demmer, Pauline Trinh, Melana Yuzefpolskaya, Yoshifumi Naka, Dan Burkhoff, Ajay Kirtane, Paolo C Colombo, Hiroo Takayama
BACKGROUND: Cardiogenic shock following acute myocardial infarction (AMI-CS) portends a poor prognosis. Short-term mechanical circulatory support devices (MCSDs) provide hemodynamic support for patients with cardiogenic shock but predictors of survival and the ability to wean from short-term MCSDs remain largely unknown. METHODS: All patients > 18 years old treated at our institution with extra-corporeal membrane oxygenation or short-term surgical ventricular assist device for AMI-CS were studied...
November 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/29079548/a-next-generation-sequencing-custom-gene-panel-as-first-line-diagnostic-tool-for-atypical-cases-of-syndromic-obesity-application-in-a-case-of-alstr%C3%A3-m-syndrome
#5
Paolo E Maltese, Giancarlo Iarossi, Lucia Ziccardi, Leonardo Colombo, Luca Buzzonetti, Crino' Antonino, Silvia Tezzele, Matteo Bertelli
Obesity phenotype can be manifested as an isolated trait or accompanied by multisystem disorders as part of a syndromic picture. In both situations, same molecular pathways may be involved to different degrees. This evidence is stronger in syndromic obesity, in which phenotypes of different syndromes may overlap. In these cases, genetic testing can unequivocally provide a final diagnosis. Here we describe a patient who met the diagnostic criteria for Alström syndrome only during adolescence. Genetic testing was requested at 25 years of age for a final confirmation of the diagnosis...
October 24, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29066254/ci8-short-a-novel-lps-induced-peptide-from-the-ascidian-ciona-intestinalis-modulates-responses-of-the-human-immune-system
#6
Angela Bonura, Aiti Vizzini, Sara Vlah, Francesco Gervasi, Alessandra Longo, Mario R Melis, Frank A Schildberg, Paolo Colombo
The selective modulation of immunity is an emerging concept driven by the vast advances in our understanding of this crucial host defense system. Invertebrates have raised researchers' interest as potential sources of new bioactive molecules owing to their antibacterial, anticancer and immunomodulatory activities. A LipoPolySaccharide (LPS) challenge in the ascidian Ciona intestinalis generates the transcript, Ci8 short, with cis-regulatory elements in the 3' UTR region that are essential for shaping innate immune responses...
October 16, 2017: Immunobiology
https://www.readbyqxmd.com/read/29050454/amelanotic-desmoplastic-melanoma-arising-on-an-occipito-parietal-burn-scar
#7
Ginevra Pertusi, Benedetta Miglino, Roberto Giorgione, Antonio Ramponi, Massimo Gattoni, Paolo Boggio, Stefano Astolfi, Rossana Tiberio, Federica Veronese, Francesca Graziola, Francesca Meli, Federica Bellinzona, Enrico Colombo
No abstract text is available yet for this article.
December 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29045787/mechanistic-origin-of-the-combined-effect-of-surfaces-and-mechanical-agitation-on-amyloid-formation
#8
Fulvio Grigolato, Claudio Colombo, Raffaele Ferrari, Lenka Rezabkova, Paolo Arosio
Interactions between proteins and surfaces in combination with hydrodynamic flow and mechanical agitation can often trigger the conversion of soluble peptides and proteins into aggregates, including amyloid fibrils. Despite the extensive literature on the empirical effects of surfaces and mechanical forces on the formation of amyloids, the molecular details of the mechanisms underlying this behavior are still elusive. This limitation is, in part, due to the complex reaction network underlying the formation of amyloids, where several microscopic reactions of nucleation and growth can occur both at the interfaces and in bulk...
October 25, 2017: ACS Nano
https://www.readbyqxmd.com/read/29043581/the-unique-blood-pressures-and-pulsatility-of-lvad-patients-current-challenges-and-future-opportunities
#9
REVIEW
Francesco Castagna, Eric J Stöhr, Alberto Pinsino, John R Cockcroft, Joshua Willey, A Reshad Garan, Veli K Topkara, Paolo C Colombo, Melana Yuzefpolskaya, Barry J McDonnell
An increasing number of end-stage heart failure patients are now implanted with continuous-flow left ventricular assist devices (CF-LVADs). Although this therapeutic approach is associated with improved clinical outcomes, continuous flow physiology reduces arterial pulse pressure and pulsatility to an extent that is unique to this population. Recent data suggest that high blood pressure (BP) contributes to life-threatening complications such as pump thrombosis and stroke of CF-LVAD patients. However, limited understanding of the distinct hemodynamics of these pumps makes measurement and, consequently, medical management of BP quite challenging...
October 18, 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28987395/abciximab-heparin-therapy-for-left-ventricular-assist-device-implantation-in-patients-with-heparin-induced-thrombocytopenia
#10
Chia-Ling Lee, Paolo C Colombo, Andrew Eisenberger, David Diuguid, Douglas L Jennings, Jiho Han, Michael P Salna, Koji Takeda, Paul A Kurlansky, Melana Yuzefpolskaya, Arthur R Garan, Yoshifumi Naka, Hiroo Takayama
BACKGROUND: Optimal anticoagulation strategy remains uncertain in patients with heparin-induced thrombocytopenia (HIT) and undergoing left ventricular assist device (LVAD) implantation. We describe our protocol of abciximab and heparin in these patients. METHODS: Our protocol is to administer abciximab, 0.25 mg/kg loading dose, followed by continuous infusion of 0.125 μg · kg(-1) · min(-1) throughout cardiopulmonary bypass. Full-dose heparin is then given with subsequent additional doses to maintain an activated clotting time of 400 seconds or longer...
October 4, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28966155/one-year-clinical-outcomes-after-unrestricted-implantation-of-absorb-bioresorbable-scaffold-rai-registry
#11
Alfonso Ielasi, Bernardo Cortese, Elisabetta Moscarella, Bruno Loi, Giuseppe Tarantini, Attilio Varricchio, Francesco Pisano, Alessandro Durante, Giampaolo Pasquetto, Alessandro Colombo, Gabriele Tumminello, Luciano Moretti, Paolo Calabrò, Pietro Mazzarotto, Maurizio Tespili, Donatella Corrado, Giuseppe Steffenino
AIMS: to assess the outcomes following Absorb bioresorbable scaffold (BVS) implantation in an unrestricted clinical practice according to an "on-label" versus "off-label" indication. METHODS AND RESULTS: RAI is a prospective registry, investigating the BVS performance in different lesions subsets. No specific exclusion criteria were applied. Co-primary end-points were target lesion revascularization (TLR) and definite/probable scaffold thrombosis (ScT) at one-year...
October 3, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28964645/proteinuria-in-left-ventricular-assist-device-candidates-an-emerging-risk-factor-for-renal-failure-and-mortality
#12
EDITORIAL
Veli K Topkara, Paolo C Colombo
No abstract text is available yet for this article.
September 14, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28932227/targeted-delivery-of-neutralizing-anti-c5-antibody-to-renal-endothelium-prevents-complement-dependent-tissue-damage
#13
Paolo Durigutto, Daniele Sblattero, Stefania Biffi, Luca De Maso, Chiara Garrovo, Gabriele Baj, Federico Colombo, Fabio Fischetti, Antonio F Di Naro, Francesco Tedesco, Paolo Macor
Complement activation is largely implicated in the pathogenesis of several clinical conditions and its therapeutic neutralization has proven effective in preventing tissue and organ damage. A problem that still needs to be solved in the therapeutic control of complement-mediated diseases is how to avoid side effects associated with chronic neutralization of the complement system, in particular, the increased risk of infections. We addressed this issue developing a strategy based on the preferential delivery of a C5 complement inhibitor to the organ involved in the pathologic process...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28922954/determinants-of-carotid-femoral-pulse-wave-velocity-progression-in-hypertensive-patients-over-a-3-7-years-follow-up
#14
Paolo Meani, Alessandro Maloberti, Paola Sormani, Giulia Colombo, Luca Giupponi, Miriam Stucchi, Marisa Varrenti, Paola Vallerio, Rita Facchetti, Guido Grassi, Giuseppe Mancia, Cristina Giannattasio
OBJECTIVE: The role of risk factors on the progression of arterial stiffness has not yet been extensively evaluated. The aim of the current longitudinal study was to evaluate the determinants of the PWV progression over a 4 years follow-up period in hypertensive subjects. MATERIALS AND METHODS: We enrolled 333 consecutive hypertensive outpatients 18-80 aged, followed by the Hypertension Unit of St. Gerardo Hospital (Monza, Italy). At baseline anamnestic, clinical, BP, laboratory data and cfPWV were assessed...
September 18, 2017: Blood Pressure
https://www.readbyqxmd.com/read/28917595/perioperative-and-oncologic-outcomes-of-nephrectomy-and-caval-thrombectomy-using-extracorporeal-circulation-and-deep-hypothermic-circulatory-arrest-for-renal-cell-carcinoma-invading-the-supradiaphragmatic-inferior-vena-cava-and-or-right-atrium
#15
Alessandro Nini, Umberto Capitanio, Alessandro Larcher, Paolo Dell'Oglio, Federico Dehò, Nazareno Suardi, Fabio Muttin, Cristina Carenzi, Massimo Freschi, Roberta Lucianò, Giovanni La Croce, Alberto Briganti, Renzo Colombo, Andrea Salonia, Alessandro Castiglioni, Patrizio Rigatti, Francesco Montorsi, Roberto Bertini
BACKGROUND: Radical nephrectomy (RN) and caval thrombectomy (CT) for renal cell carcinoma, with extracorporeal circulation (ECC) and deep hypothermic circulatory arrest (DHCA) is a challenging surgical approach. OBJECTIVE: To assess peri-operative and oncologic outcomes of renal cell carcinoma patients treated with RN and CT, using ECC and DHCA. DESIGN, SETTING, AND PARTICIPANTS: We retrospectively evaluated 46 patients who underwent RN and CT using ECC and DHCA...
September 13, 2017: European Urology
https://www.readbyqxmd.com/read/28906093/cutaneous-extramedullary-hematopoiesis
#16
Benedetta Miglino, Rossana Tiberio, Paolo Boggio, Stefano Astolfi, Monica Leutner, Enrico Colombo
No abstract text is available yet for this article.
October 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28887096/predicting-local-failure-after-radical-cystectomy-in-patients-with-bladder-cancer-implications-for-the-selection-of-candidates-at-adjuvant-radiation-therapy
#17
Marco Moschini, Shahrokh F Shariat, Mohammad Abufaraj, Beat Foerster, David D Andrea, Francesco Soria, Paolo Dell Oglio, Agostino Mattei, Francesco Montorsi, Renzo Colombo, Alberto Briganti, Andrea Gallina
OBJECTIVE: To evaluate incidence and predictors of local failure (LF) after radical cystectomy (RC) due to bladder cancer. METHODS: We focused on 1,112 patients treated with RC, between 1990 and 2012, at a single center. LF was defined as imaging evidence of recurrence in the pelvic soft tissues or nodes below the aortic bifurcation at least 3 months before the detection of distant metastases. Competing risk analyses tested the relationship between clinical and pathological factors and the risk to develop LF...
September 5, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28885380/use-of-durable-continuous-flow-ventricular-assist-devices-in-patients-on-immunosuppression
#18
Robert A Sorabella, Jiho Han, Veli K Topkara, A Reshad Garan, Melana Yuzefpolskaya, Paolo C Colombo, Koji Takeda, Yoshifumi Naka, Hiroo Takayama
Durable ventricular assist device (VAD) therapy remains an important treatment for end-stage heart failure. Despite advancements in device design, postimplant infectious complications continue to plague this population. In this study, we aim to evaluate the use of durable VAD therapy in patients on active immunosuppression. All patients undergoing durable, continuous-flow VAD placement on active immunosuppression at our center from 2004 to 2012 were included in the analysis (group immunosuppressed [IS]; n = 13)...
September 5, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28859182/evaluation-of-a-new-ultrasonic-insert-for-prosthodontic-preparation
#19
Domenico Baldi, Maria Menini, Jacopo Colombo, Enrico Lertora, Paolo Pera
PURPOSE: This paper describes a new ultrasonic instrument (tipholder DB1 with crown prep tip inserts) designed to optimize prosthodontic margin repositioning and finishing. MATERIALS AND METHODS: The insert movement was assessed, and it was demonstrated that tipholder DB1 provides its inserts with an elliptical-like movement, making the entire insert surface able to cut. Then, 20 extracted teeth were prepared using tipholder DB1, sonic instruments, and traditional drills...
September 2017: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/28822659/incidence-and-risk-factors-of-groin-lymphocele-formation-after-venoarterial-extracorporeal-membrane-oxygenation-in-cardiogenic-shock-patients
#20
Michael Salna, Hiroo Takayama, Arthur R Garan, Paul Kurlansky, Maryjane A Farr, Paolo C Colombo, Thomas Imahiyerobo, Nicholas Morrissey, Yoshifumi Naka, Koji Takeda
OBJECTIVE: Venous-arterial extracorporeal membrane oxygenation (VA-ECMO) is a well-established therapy for refractory cardiopulmonary failure. Femoral cannulation offers a quick and effective means of providing circulatory support but is not without complication. Inflammation or lymphatic disruption at the site of cannulation can cause the formation of lymphoceles, leading to the patient's discomfort and possibly necessitating intervention. The purpose of this study was to evaluate the incidence of in-hospital lymphocele formation in VA-ECMO patients and to identify predictors for their development...
August 16, 2017: Journal of Vascular Surgery
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