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Breat cancer

Paolo Romano, Aldo Profumo, Mattia Rocco, Rosa Mangerini, Fabio Ferri, Angelo Facchiano
BACKGROUND: Mass spectrometry (MS) is producing high volumes of data supporting oncological sciences, especially for translational research. Most of related elaborations can be carried out by combining existing tools at different levels, but little is currently available for the automation of the fundamental steps. For the analysis of MALDI/TOF spectra, a number of pre-processing steps are required, including joining of isotopic abundances for a given molecular species, normalization of signals against an internal standard, background noise removal, averaging multiple spectra from the same sample, and aligning spectra from different samples...
2016: BMC Bioinformatics
Meng-Chuan Wang, Ai-Guo Wu, Yi-Zhe Huang, Guo-Li Shao, Shu-Feng Ji, Ri-Wei Wang, Hong-Jun Yuan, Xu-Long Fan, Lin-Hai Zheng, Qing-Li Jiao
Beclin 1 is a promoter gene for autophagy as well as a key factor for regulating tumor cell growth and death. Allelic deletion of Beclin 1 has been observed in certain triple-negative breat cancer (TNBC) cells, and it might be associated with increased proliferation and invasion in TNBC cells. In this study we investigated the relationship between Beclin 1 expression and prognosis for TNBC patients, as well as the influence on cell growth by Beclin 1 overexpression in different cultural conditions. Beclin 1 expression in TNBC tissues was measured by immunohistochemical staining and correlated with clinicopathologic parameters for TNBC patients...
2015: International Journal of Clinical and Experimental Medicine
Stefan Feiten, Jan Dünnebacke, Jochen Heymanns, Hubert Köppler, Jörg Thomalla, Christoph van Roye, Diana Wey, Rudolf Weide
BACKGROUND: Many women have symptoms of various kinds after being treated for breast cancer. It is unclear how frequently these different side effects of treatment arise. METHOD: All women who underwent surgery for breast cancer and subsequently received adjuvant systemic treatment in a single certified breast-cancer center from 2006 to 2010 were asked to fill out a standardized questionnaire. Medical data were retrieved from their charts and statistically analyzed together with the questionnaire responses...
August 4, 2014: Deutsches Ärzteblatt International
Tamás Mersich, Sándor Faludi, Orsolya Ping, Jenő Jóbaházi, Balázs Szabó, Kristóf Dede, István Besznyák, Attila Bursics
INTRODUCTION: Sentinel biopsy technique was performed in Europe in 1996.It was a great improvement in the surgical treatment of breast cancer, it decreased the number of patients suffering from early and late morbidity following axillary lymph node dissection (ALND). In our paper we demonstrate the evolution of sentinel biopsy technique (SLNB), as well as the changes in our policy on axillary treatment in line with the European trends. METHODS: The authors of this article give an overview and analyse the relevant literature concerning sentinel lymph node biopsy and data of patients on whom sentinel lymph node biopsy was performed from 01/01/2001 to 31/12/2012...
December 2013: Magyar Sebészet
A Lebris, A Vildé, H Marret, G Body, L Ouldamer
OBJECTIVE: To investigate the role of imaging procedures in the diagnosis of synchronous bilateral breast cancer (SBBC) PATIENTS AND METHODS: The patient group consisted of consecutive women undergoing managed for SBBC in our institution between January 2006 and July 2012. We defined SBBC as bilateral breast tumors diagnosed simultaneously or up to 3 months after initial diagnosis. Clinical data included comorbidities, BMI (kg/m(2)), preoperative breast imaging modalities used and their findings...
January 2014: Gynécologie, Obstétrique & Fertilité
Feng Tang, Rui Zhang, Yunmian He, Meijuan Zou, Le Guo, Tao Xi
MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression by targeting mRNAs to trigger either translation repression or mRNA degradation. miR-125b is down-regulated in human breast cancer cells compared with the normal ones except highly metastatic tumor cells MDA-MB-231. However, few functional studies were designed to investigate metastatic potential of miR-125b. In this study, the effects of miR-125b on metastasis in human breast cancer cells were studied, and the targets of miR-125b were also explored...
2012: PloS One
H S Sheshadri, A Kandaswamy
An important approach for describing a region is to quantify its structure content. In this paper, the use of functions for computing texture based on statistical measures is described. Six textural features for mammogram images are defined. The segmentation based on these textures would classify the breast tissue under four categories. The algorithm evaluates the region properties of the mammogram image and thereby would classify the image under four important categories based on the intensity level of histograms...
January 2007: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
José Antonio Sarriá
The life expectation has been changeable the manner of menopause handling. At the same time, the women after fifty have the highest incidence of cancer. The hormonal replacement therapy (HT) to date have very few indication for patients with cancer. The oncologic contraindication for HT are analysed in detail, particulary for breast tumor. At the present time, the studies and the metanalysis on HT and breat cancer not showed a quantitative increase on the risk. We are looking for selective hormone with antagonist for endometrium and breast receptors, and effectiveness on the others areas...
2005: Revista de la Facultad de Ciencias Médicas
No abstract text is available yet for this article.
1959: Voprosy Onkologii
J M Borràs, J A Espinàs, X Castells
The publication of the new Cochrane review on screening for breast cancer with mamography has revived the debate on breats screening and raised some new topics. Whereas the Cochrane reviewers reasserted on their previous conclusion of the lack of efficacy of breast screening, the new review of the Swedish studies, the new systematic review of the Agency for Healthcare Research and Quality commissioned by the US Preventive Services Task Force, and the recent review of an IARC working group supported the efficacy of breast screening after carefully considering the methodological quality of trials...
May 2003: Gaceta Sanitaria
P D Delmas
The SERMs (selective estrogen receptor modulators) are a new class of molecules that bind to the estrogen receptor, resulting in an estradiol agonist or antagonist response according to the target tissue. Raloxifene, a new SERM, has been shown to prevent postmenopausal bone loss, to reduce the risk of vertebral fractures in osteoporotic women, to decrease serum cholesterol and its LDL fraction, and to reduce significantly the risk of breat cancer. Raloxifene is available in France for the prevention of post-menopausal osteoporosis...
2000: Joint, Bone, Spine: Revue du Rhumatisme
D Pasquali, A Bellastella, A Valente, G Botti, I Capasso, S del Vecchio, M Salvatore, V Colantuoni, A A Sinisi
Retinoids seem to act as agents of chemoprevention and differentiation in breast diseases. Their action is mediated by nuclear receptors, retinoic acid receptors (RAR alpha, RAR beta, RAR gamma) and retinoid X receptors (RXR alpha, RXR beta, RXR gamma) and modulated by cellular retinol binding proteins (CRBP). There are few published data on CRBP expression. In this study, we evaluated the expression of RAR alpha, beta and gamma and CRBP type I (CRBP-I) gene expression in fibrocystic disease (FD) and in breast cancer (BC), studying 14 FD and 20 BC surgical samples by reverse transcription (RT)-PCR...
October 1997: European Journal of Endocrinology
N A Samaan, S Castillo, P N Schultz, K G Khalil, D A Johnston
Serum immunoreactive calcitonin (iCT) was measured in the peripheral blood of 29 normocalcemic patients with bronchogenic carcinoma of various pathological types and nine patients with breast cancer before and after pentagastrin stimulation. These results were compared to those found in 22 normal subjects and 30 patients with histologically proven medullary carcinoma of the thyroid. Our results revealed that 1) serum iCT levels may be abnormally high in all pathological types of bronchogenic carcinoma and in patients with breat cancer; 2) the basal level of serum iCT may be normal, but it is abnormally high after pentagastrin stimulation; 3) the increment rise of iCT after pentagastrin stimulation in the bronchogenic and breast cancer patients was significantly less than that seen in patients with medullary carcinoma of the thyroid (P less than 0...
August 1980: Journal of Clinical Endocrinology and Metabolism
V R Pennisi, A Capozzi
A national survey of plastic surgeons has been conducted to determinr the incidence of occult breat carcinoma in patients having a subcutaneous mastectomy. The results are reported herein. We believe subcutaneous mastectomy is the most effective prophylactic procedure presently available that is acceptable to women who have a high risk of developing breast cancer.
July 1975: Plastic and Reconstructive Surgery
H Nishiguchi, R Hasegawa, J Yoda, A Yamamoto, K Murakami
No abstract text is available yet for this article.
October 25, 1978: Nihon Igaku Hōshasen Gakkai Zasshi. Nippon Acta Radiologica
N Hammond, S E Jones, S E Salmon, D Patton, J Woolfenden
Technetium 99m phosphate-complex bone scans were performed in 43 women within two months of mastectomy for stage I (1 patient), stage II (28 patients), and stage III (14 patients) breast cancer. Twelve (28%) initial bone scans were interpreted as either equivocally abnormal (6 scans) or definitely abnormal (6 scans). Radiographs confirmed metastatic disease in 2 patients who were then considered ineligible for adjuvant therapy (adriamycin-cyclophosphamide with or without local radiotherapy). Of the remaining 41 eligible patients, all have received adjuvant therapy and 36 have had at least one additional bone scan at 6-month intervals...
January 1978: Cancer
R G Wiggans, P V Woolley, T Smythe, D Hoth, J S Macdonald, L Green, P S Schein
Seventy-eight advanced breast cancer patients, most of whom had had prior treatment, were treated with the synthetic antiestogen tamoxifen. The overall objective response rate was 27% (21/78). An additional 19% (15/78) showed disease stabilization. Sixty-seven percent (14/21) of the responses were in soft tissue sites, 24% (5/21) on bony sites and one each occurred in liver and nodular lung disease. Forty percent of patients with soft-tissue disease alone responded, while less than 10% of patients with visceral disease showed responses in visceral sites...
1979: Cancer Chemotherapy and Pharmacology
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