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JOURNAL ARTICLE
Eamonn P Duffy, J O Ward, L H Hale, K T Brown, Andrew J Kwilasz, Laura M Saba, Marissa A Ehringer, Ryan K Bachtell
Opioid use disorder (OUD) is an ongoing public health concern in the United States, and relatively little work has addressed how genetic background contributes to OUD. Understanding the genetic contributions to oxycodone-induced analgesia could provide insight into the early stages of OUD development. Here, we present findings from a behavioral phenotyping protocol using several inbred strains from the Hybrid Rat Diversity Panel. Our behavioral protocol included a modified "up-down" von Frey procedure to measure inherent strain differences in the sensitivity to a mechanical stimulus on the hindpaw...
April 2024: Genes, Brain, and Behavior
#22
JOURNAL ARTICLE
Francesco Pasqualetti, Michela Gabelloni, Lorenzo Faggioni, Giovanni Donato Aquaro, Fabrizio De Vietro, Vincenzo Mendola, Nicola Spina, Jessica Frey, Nicola Montemurro, Martina Cantarella, Mario Caccese, Giovanni Gadducci, Noemi Giannini, Silvia Valenti, Riccardo Morganti, Tamara Ius, Maria Caffo, Giuseppe Vergaro, Mirco Cosottini, Antonio Giuseppe Naccarato, Giuseppe Lombardi, Guido Bocci, Emanuele Neri, Fabiola Paiar
Purpose: Clinical evidence suggests an association between comorbidities and outcome in patients with glioblastoma (GBM). We hypothesised that the internal carotid artery (ICA) calcium score could represent a promising prognostic biomarker in a competing risk analysis in patients diagnosed with GBM. Methods: We validated the use of the ICA calcium score as a surrogate marker of the coronary calcium score in 32 patients with lung cancer. Subsequently, we assessed the impact of the ICA calcium score on overall survival in GBM patients treated with radio-chemotherapy...
March 6, 2024: Journal of Clinical Medicine
#23
JOURNAL ARTICLE
Miriam Albus, Tobias Zimmermann, Daniela Median, Klara Rumora, Ganna Isayeva, Melissa Amrein, Ibrahim Schaefer, Joan Walter, Evita Michel, Gabrielle Huré, Ivo Strebel, Federico Caobelli, Philip Haaf, Simon M Frey, Christian Mueller, Michael J Zellweger
AIM: We aimed to test the hypothesis if combining coronary artery calcium score (Ca-score) as a quantitative anatomical marker of coronary atherosclerosis with high-sensitive cardiac troponin as a quantitative biochemical marker of myocardial injury provided incremental value in the detection of functional relevant CAD (fCAD) and risk stratification. METHODS AND RESULTS: Consecutive patients undergoing myocardial perfusion SPECT (MPS) without prior CAD were enrolled...
April 9, 2024: European Heart Journal Cardiovascular Imaging
#24
JOURNAL ARTICLE
Swathi K Hullugundi, Jennifer Dolkas, Andrei V Chernov, Tony L Yaksh, Kelly A Eddinger, Mila Angert, Glaucilene Ferreira Catroli, Alex Y Strongin, Patrick M Dougherty, Yan Li, Oswal Quehenberger, Aaron Armando, Veronica I Shubayev
BACKGROUND: A bioactive myelin basic protein (MBP) fragment, comprising MBP84-104 , is released in sciatic nerve after chronic constriction injury (CCI). Intraneural injection (IN) of MBP84-104 in an intact sciatic nerve is sufficient to induce persistent neuropathic pain-like behavior via robust transcriptional remodeling at the injection site and ipsilateral dorsal root ganglia (DRG) and spinal cord. The sex (female)-specific pronociceptive activity of MBP84-104 associates with sex-specific changes in cholesterol metabolism and activation of estrogen receptor (ESR)1 signaling...
July 2024: Brain, behavior, & immunity health
#25
JOURNAL ARTICLE
Karen-Amanda Irvine, Xiao-You Shi, Adam R Ferguson, David Clark
Traumatic Brain Injury (TBI) patients frequently experience chronic pain that can enhance their suffering and significantly impair rehabilitative efforts. Clinical studies suggest that damage to the periaqueductal grey matter (PAG) following TBI, a principal center involved in endogenous pain control, may underlie the development of chronic pain. We hypothesized that TBI would diminish the usual pain control functions of the PAG, but that directly stimulating this center using a chemogenetic approach would restore descending pain modulation...
April 8, 2024: Journal of Neurotrauma
#26
JOURNAL ARTICLE
Stefan Blankenberg, Moritz Seiffert, Reinhard Vonthein, Helmut Baumgartner, Sabine Bleiziffer, Michael A Borger, Yeong-Hoon Choi, Peter Clemmensen, Jochen Cremer, Martin Czerny, Nina Diercks, Ingo Eitel, Stephan Ensminger, Derk Frank, Norbert Frey, Andreas Hagendorff, Christian Hagl, Christian Hamm, Utz Kappert, Matthias Karck, Won-Keun Kim, Inke R König, Markus Krane, Ulf Landmesser, Axel Linke, Lars S Maier, Steffen Massberg, Franz-Josef Neumann, Hermann Reichenspurner, Tanja K Rudolph, Christof Schmid, Holger Thiele, Raphael Twerenbold, Thomas Walther, Dirk Westermann, Erion Xhepa, Andreas Ziegler, Volkmar Falk
BACKGROUND: Among low-risk patients with severe, symptomatic aortic stenosis who are eligible for both transcatheter aortic-valve implantation (TAVI) and surgical aortic-valve replacement (SAVR), data are lacking on the appropriate treatment strategy in routine clinical practice. METHODS: In this randomized noninferiority trial conducted at 38 sites in Germany, we assigned patients with severe aortic stenosis who were at low or intermediate surgical risk to undergo either TAVI or SAVR...
April 8, 2024: New England Journal of Medicine
#27
JOURNAL ARTICLE
Verena Kufner, Andrea C Frey, Sara H Burkhard, Stefan Schmutz, Gabriela Ziltener, Maryam Zaheri, Caroline V Wiedmer, Andreas Plate, Alexandra Trkola, Michael Huber, Nicolas J Mueller
AIMS OF THE STUDY: Upper respiratory tract infections are among the most common reasons for primary care consultations. They are diagnosed predominantly based on clinical assessment. Here, we investigated the benefit of viral metagenomic next-generation sequencing (mNGS) in an outpatient setting. METHODS: This prospective cross-sectional study included immunocompetent patients with acute upper respiratory tract infections. General practitioners collected pharyngeal swabs and demographic and clinical data...
April 5, 2024: Swiss Medical Weekly
#28
JOURNAL ARTICLE
Daisuke Uta, Naoya Ishibashi, Shinichi Tao, Masahito Sawahata, Toshiaki Kume
Photobiomodulation (PBM) has attracted attention as a treatment for chronic pain. Previous studies have reported that PBM of the sciatic nerve inhibits neuronal firing in the superficial layers (lamina I-II) of the spinal dorsal horn of rats, which is evoked by mechanical stimulation that corresponds to noxious stimuli. However, the effects of PBM on the deep layers (lamina III-IV) of the spinal dorsal horn, which receive inputs from innocuous stimuli, remain poorly understood. In this study, we examined the effect of PBM of the sciatic nerve on firing in the deep layers of the spinal dorsal horn evoked by mechanical stimulation...
March 30, 2024: Biochemical and Biophysical Research Communications
#29
JOURNAL ARTICLE
Logan F Condon, Ying Yu, Sekun Park, Feng Cao, Jordan L Pauli, Tyler S Nelson, Richard D Palmiter
Pain that persists beyond the time required for tissue healing and pain that arises in the absence of tissue injury, collectively referred to as nociplastic pain, are poorly understood phenomena mediated by plasticity within the central nervous system. The parabrachial nucleus (PBN) is a hub that relays aversive sensory information and appears to play a role in nociplasticity. Here, by preventing PBN Calca neurons from releasing neurotransmitters, we demonstrate that activation of Calca neurons is necessary for the manifestation and maintenance of chronic pain...
April 6, 2024: Cell Reports
#30
JOURNAL ARTICLE
Adile Nexha, Luisa K Pilz, Melissa A B Oliveira, Nicoli B Xavier, Rogério Boff Borges, Benicio N Frey, Maria Paz L Hidalgo
BACKGROUND: Depression and anxiety affect hundreds of millions of people worldwide, and their prevalence increased during the COVID-19 pandemic as social schedules were disrupted. This study explores the associations between anxiety and depression and within- and between-day instability of affective, somatic, and cognitive symptoms during the early pandemic stages. METHODS: Participants (n = 153, ages 18-77, 72 % female) reported daily levels of affective (anxiety/sadness), somatic (appetite/sleepiness), and cognitive (concentration/energy) symptoms for 14-44 days at five timepoints: 0, 3, 6, 9, and 12 h after awakening...
April 4, 2024: Journal of Affective Disorders
#31
JOURNAL ARTICLE
Matthias Eden, Marius Leye, Justus Hahn, Emanuel Heilein, Marcin Luzarowski, Bill Völschow, Christin Tannert, Samuel Sossalla, Carlota Lucena-Porcel, Derk Frank, Norbert Frey
Myocardial failure is associated with adverse remodeling which includes apoptotic loss of cardiomyocytes, hypertrophy as well as alterations in cell-cell contacts. Striatin-interacting phosphatase and kinase (STRIPAK) complexes and their kinase Mst4 have been linked to the development of different diseases. The role and targets of Mst4 in cardiomyocytes have not been investigated, yet. Multi tissue immunoblot experiments show highly enriched Mst4-expression in rodent hearts. Analyses of human biopsy samples from patients suffering from dilated cardiomyopathy revealed that Mst4 is upregulated (5,8-fold p<0...
April 3, 2024: Journal of Biological Chemistry
#32
JOURNAL ARTICLE
Beat Frey, Margherita Aiesi, Basil M Rast, Joel Rüthi, Jérôme Julmi, Beat Stierli, Weihong Qi, Ivano Brunner
Plastic materials, including microplastics, accumulate in all types of ecosystems, even in remote and cold environments such as the European Alps. This pollution poses a risk for the environment and humans and needs to be addressed. Using shotgun DNA metagenomics of soils collected in the eastern Swiss Alps at about 3,000 m a.s.l., we identified genes and their proteins that potentially can degrade plastics. We screened the metagenomes of the plastisphere and the bulk soil with a differential abundance analysis, conducted similarity-based screening with specific databases dedicated to putative plastic-degrading genes, and selected those genes with a high probability of signal peptides for extracellular export and a high confidence for functional domains...
2024: PloS One
#33
JOURNAL ARTICLE
Assessment of Multisensory Sensitivity May Assist With the Management of Children With Chronic Pain.
Anureet Walia, Crystal Markfort, Laura Frey-Law
Chronic pain is a significant problem in adults; however, it can also be challenging to evaluate and manage effectively in pediatric and adolescent populations. Many theories implicate different factors that cause pain to become chronic, more severe, or more detrimental to function. There is emerging evidence for the role of generalized multisensory sensitivity (MSS) as a contributing factor to chronic pain in the adult population; however, similar evidence in the pediatric literature is lacking. Thus, the purpose of this case series is to highlight the clinical use of MSS assessment in children and adolescents with chronic pain to better phenotype and provide targeted treatment...
April 5, 2024: Pediatrics
#34
JOURNAL ARTICLE
Xian-Da Chai, Huan Jiang, Ling-Ling Tang, Jing Zhang, Long-Fei Yue
BACKGROUND: Frey syndrome, also known as ototemporal nerve syndrome or gustatory sweating syndrome, is one of the most common complications of parotid gland surgery. This condition is characterized by abnormal sensations in the facial skin accompanied by episodes of flushing and sweating triggered by cognitive processes, visual stimuli, or eating. AIM: To investigate the preventive effect of acellular dermal matrix (ADM) on Frey syndrome after parotid tumor resection and analyzed the effects of Frey syndrome across various surgical methods and other factors involved in parotid tumor resection...
March 26, 2024: World Journal of Clinical Cases
#35
JOURNAL ARTICLE
Mariacristina Mazzitelli, Olga Ponomareva, Peyton Presto, Julia John, Volker Neugebauer
Introduction: Pain is a clinically relevant health care issue with limited therapeutic options, creating the need for new and improved analgesic strategies. The amygdala is a limbic brain region critically involved in the regulation of emotional-affective components of pain and in pain modulation. The central nucleus of amygdala (CeA) serves major output functions and receives nociceptive information via the external lateral parabrachial nucleus (PB). While amygdala neuroplasticity has been linked causally to pain behaviors, non-neuronal pain mechanisms in this region remain to be explored...
2024: Frontiers in Pharmacology
#36
JOURNAL ARTICLE
Maria Dalla Fontana, Simone Anesi, Michal Czopowicz, Sandra A Corr
BACKGROUND: This study aimed to investigate the possible presence of maladaptive pain in the thoracic limbs of dogs with elbow osteoarthritis (OA) using an electronic von Frey aesthesiometer (eVFA). METHODS: Twenty-eight client- and staff-owned dogs (OA, n = 14; controls, n = 14) were enrolled in the study. Every dog underwent a full orthopaedic examination, and then five von Frey measurements were obtained from each carpal pad of each dog. A maximum test threshold of 400 g was set and approved by an ethics committee...
April 4, 2024: Veterinary Record
#37
JOURNAL ARTICLE
Diana Czepiel, Clare McCormack, Andréa T C da Silva, Dominika Seblova, Maria F Moro, Alexandra Restrepo-Henao, Adriana M Martínez, Oyeyemi Afolabi, Lubna Alnasser, Rubén Alvarado, Hiroki Asaoka, Olatunde Ayinde, Arin Balalian, Dinarte Ballester, Josleen A L Barathie, Armando Basagoitia, Djordje Basic, María S Burrone, Mauro G Carta, Sol Durand-Arias, Mehmet Eskin, Eduardo Fernández-Jiménez, Marcela I F Frey, Oye Gureje, Anna Isahakyan, Rodrigo Jaldo, Elie G Karam, Dorra Khattech, Jutta Lindert, Gonzalo Martínez-Alés, Franco Mascayano, Roberto Mediavilla, Javier A Narvaez Gonzalez, Aimee Nasser-Karam, Daisuke Nishi, Olusegun Olaopa, Uta Ouali, Victor Puac-Polanco, Dorian E Ramírez, Jorge Ramírez, Eliut Rivera-Segarra, Bart P F Rutten, Julian Santaella-Tenorio, Jaime C Sapag, Jana Šeblová, María T S Soto, Maria Tavares-Cavalcanti, Linda Valeri, Marit Sijbrandij, Ezra S Susser, Hans W Hoek, Els van der Ven
Healthcare workers (HCWs) were at increased risk for mental health problems during the COVID-19 pandemic, with prior data suggesting women may be particularly vulnerable. Our global mental health study aimed to examine factors associated with gender differences in psychological distress and depressive symptoms among HCWs during COVID-19. Across 22 countries in South America, Europe, Asia and Africa, 32,410 HCWs participated in the COVID-19 HEalth caRe wOrkErS (HEROES) study between March 2020 and February 2021...
2024: Global Mental Health
#38
JOURNAL ARTICLE
Nodoka Kato, Toshie Kambe, Terumasa Chiba, Kyoji Taguchi, Kenji Abe
OBJECTIVES: Neuropathic pain is characterized by long-lasting, intractable pain. Sciatic nerve ligation is often used as an animal model of neuropathic pain, and the spared nerve injury (SNI) model, in which the common peroneal nerve (CPN) and tibial nerve (TN) are ligated, is widely used. In the present study, we evaluated the analgesic effect of a cholinergic agonist, carbachol, on a neuropathic pain model prepared by sural nerve (SN) ligation in mice. METHODS: The SN was tightly ligated as a branch of the sciatic nerve...
April 3, 2024: Neurological Research
#39
JOURNAL ARTICLE
Thomas Müller-Tasch, Bernd Löwe, Lutz Frankenstein, Norbert Frey, Markus Haass, Hans-Christoph Friederich
BACKGROUND: Patients with chronic heart failure (CHF) frequently suffer from depressive comorbidity. CHF and depressive comorbidity can cause somatic symptoms. The correct attribution of somatic symptoms is important. Thus, we aimed to assess potential differences in somatic symptom severity between CHF patients with and without depressive comorbidity. METHODS: We evaluated depressive comorbidity using the Patient Health Questionnaire-9 (PHQ-9), somatic symptom severity with the Patient Health Questionnaire-15 (PHQ-15), and sociodemographic and medical variables in 308 CHF outpatients...
2024: Frontiers in Psychiatry
#40
JOURNAL ARTICLE
Yingyuan Liu, Zihua Gong, Deqi Zhai, Chunxiao Yang, Guangshuang Lu, Shuqing Wang, Shaobo Xiao, Chenhao Li, Ludan Chen, Xiaoxue Lin, Shuhua Zhang, Shengyuan Yu, Zhao Dong
BACKGROUND: Migraine stands as a prevalent primary headache disorder, with prior research highlighting the significant involvement of oxidative stress and inflammatory pathways in its pathogenesis and chronicity. Existing evidence indicates the capacity of Dl-3-n-butylphthalide (NBP) to mitigate oxidative stress and inflammation, thereby conferring neuroprotective benefits in many central nervous system diseases. However, the specific therapeutic implications of NBP in the context of migraine remain to be elucidated...
April 2, 2024: Journal of Headache and Pain
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