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https://www.readbyqxmd.com/read/28821203/a-clinician-s-plea-to-test-glioma-patients-for-cmv
#1
Nicole Lydia Goerig, Benjamin Frey, Klaus Überla, Udo Gaipl, Rainer Fietkau
No abstract text is available yet for this article.
September 1, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28821170/esc-joint-working-groups-on-cardiovascular-surgery-and-the-cellular-biology-of-the-heart-position-paper-perioperative-myocardial-injury-and-infarction-in-patients-undergoing-coronary-artery-bypass-graft-surgery
#2
Matthias Thielmann, Vikram Sharma, Nawwar Al-Attar, Heerajnarain Bulluck, Gianluigi Bisleri, Jeroen Jh Bunge, Martin Czerny, Péter Ferdinandy, Ulrich H Frey, Gerd Heusch, Johannes Holfeld, Petra Kleinbongard, Gudrun Kunst, Irene Lang, Salvatore Lentini, Rosalinda Madonna, Patrick Meybohm, Claudio Muneretto, Jean-Francois Obadia, Cinzia Perrino, Fabrice Prunier, Joost P G Sluijter, Linda W Van Laake, Miguel Sousa-Uva, Derek J Hausenloy
No abstract text is available yet for this article.
August 14, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28821113/fabrication-of-thermo-responsive-cotton-fabrics-using-poly-vinyl-caprolactam-co-hydroxyethyl-acrylamide-copolymer
#3
Min Xiao, Edurne González, Alexis Martell Monterroza, Margaret Frey
A thermo-responsive polymer with hydrophilic to hydrophobic transition behavior, poly(vinyl caprolactam-co-hydroxyethyl acrylamide) P(VCL-co-HEAA), was prepared by copolymerization of vinyl caprolactam and N-hydroxyethyl acrylamide via free radical solution polymerization. The resulting copolymer was characterized by Fourier transform infrared spectroscopy (FTIR), (1)H nuclear magnetic resonance (NMR), gel permeation chromatography (GPC), differential scanning calorimetry (DSC), and thermogravimetric analysis (TGA)...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821081/direct-characterization-of-cotton-fabrics-treated-with-di-epoxide-by-nuclear-magnetic-resonance
#4
Min Xiao, Joronia Chéry, Ivan Keresztes, David B Zax, Margaret W Frey
A non-acid-based, di-functional epoxide, neopentyl glycol diglycidyl ether (NPGDGE), was used to modify cotton fabrics. Direct characterization of the modified cotton was conducted by Nuclear Magnetic Resonance (NMR) without grinding the fabric into a fine powder. NaOH and MgBr2 were compared in catalyzing the reaction between the epoxide groups of NPGDGE and the hydroxyl groups of cellulose. Possible reaction routes were discussed. Scanning electron microscopy (SEM) images showed that while the MgBr2-catalyzed reaction resulted in self-polymerization of NPGDGE, the NaOH-catalyzed reaction did not...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28819928/development-of-a-rating-tool-for-mobile-cancer-apps-information-analysis-and-formal-and-content-related-evaluation-of-selected-cancer-apps
#5
Cathleen Böhme, Marc Baron von Osthoff, Katrin Frey, Jutta Hübner
Mobile apps are offered in large numbers and have different qualities. The aim of this article was to develop a rating tool based on formal and content-related criteria for the assessment of cancer apps and to test its applicability on apps. After a thorough analysis of the literature, we developed a specific rating tool for cancer apps based on the MARS (mobile app rating system) and a rating tool for cancer websites. This instrument was applied to apps freely available in stores and focusing on some cancer topic...
August 17, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28817317/living-outside-the-gender-box-in-mexico-testimony-of-transgender-mexican-asylum-seekers
#6
Marshall K Cheney, Mary J Gowin, E Laurette Taylor, Melissa Frey, Jamie Dunnington, Ghadah Alshuwaiyer, J Kathleen Huber, Mary Camero Garcia, Grady C Wray
OBJECTIVES: To explore preimmigration experiences of violence and postimmigration health status in male-to-female transgender individuals (n = 45) from Mexico applying for asylum in the United States. METHODS: We used a document review process to examine asylum declarations and psychological evaluations of transgender Mexican asylum seekers in the United States from 2012. We coded documents in 2013 and 2014 using NVivo, a multidisciplinary team reviewed them, and then we analyzed them for themes...
August 17, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28815599/the-reduction-of-intraepidermal-p2x3-nerve-fiber-density-correlates-with-behavioral-hyperalgesia-in-a-rat-model-of-nerve-injury-induced-pain
#7
Malik Bechakra, Barthold N Schüttenhelm, Tiziana Pederzani, Pieter A van Doorn, Chris I de Zeeuw, Joost L M Jongen
Skin biopsies from patients with neuropathic pain often show changes in epidermal innervation, although it remains to be elucidated to what extent such changes can be linked to a particular subgroup of nerve fibers and how these changes are correlated with pain intensity. Here, we investigated to what extent behavioral signs of hyperalgesia are correlated with immunohistochemical changes of peptidergic and non-peptidergic epidermal nerve fibers in a rat model of nerve injury-induced pain. Rats subjected to unilateral partial ligation of the sciatic nerve developed significant mechanical and thermal hyperalgesia as tested by the withdrawal responses of the ipsilateral footpad to von Frey hairs and hotplate stimulation...
August 17, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28814665/fatty-acid-oxidation-by-the-osteoblast-is-required-for-normal-bone-acquisition-in-a-sex-and-diet-dependent-manner
#8
Soohyun P Kim, Zhu Li, Meredith L Zoch, Julie L Frey, Caitlyn E Bowman, Priyanka Kushwaha, Kathleen A Ryan, Brian C Goh, Susanna Scafidi, Julie E Pickett, Marie-Claude Faugere, Erin E Kershaw, Daniel L J Thorek, Thomas L Clemens, Michael J Wolfgang, Ryan C Riddle
Postnatal bone formation is influenced by nutritional status and compromised by disturbances in metabolism. The oxidation of dietary lipids represents a critical source of ATP for many cells but has been poorly studied in the skeleton, where the prevailing view is that glucose is the primary energy source. Here, we examined fatty acid uptake by bone and probed the requirement for fatty acid catabolism during bone formation by specifically disrupting the expression of carnitine palmitoyltransferase 2 (Cpt2), an obligate enzyme in fatty acid oxidation, in osteoblasts and osteocytes...
August 17, 2017: JCI Insight
https://www.readbyqxmd.com/read/28814157/the-role-and-mechanism-of-glutamic-nmda-receptor-in-the-mechanical-hyperalgesia-in-diabetic-rats
#9
Jin Wang, Zhaohui Sun, Yuzhao Wang, Huisheng Wang, Yuan Guo
OBJECTIVES: Some studies have shown that painful neuropathy is a common and costly complication of both type 1 and type 2 diabetes mellitus, and glutamate is involved in the process although the mechanisms are not clear. The purpose of the present study was to investigate the effect of N-methyl-D-aspartate (NMDA) receptor on mechanical hyperalgesia in diabetic rats and the possible mechanism. METHODS: Diabetic rat model was established by intraperitoneal injection of streptozotocin (STZ, 1%, 70 mg/kg) once, and evaluated by the change in the fasting blood glucose...
August 17, 2017: Neurological Research
https://www.readbyqxmd.com/read/28812633/diversity-begets-diversity-in-competition-for-space
#10
Daniel S Maynard, Mark A Bradford, Daniel L Lindner, Linda T A van Diepen, Serita D Frey, Jessie A Glaeser, Thomas W Crowther
Competition can profoundly affect biodiversity patterns by determining whether similar species are likely to coexist. When species compete directly for space, competitive ability differences should theoretically promote trait and phylogenetic clustering, provided that niche differences are otherwise minimal. Yet many sessile communities exhibit high biodiversity despite minimal reliance on niche differentiation. A potential explanation is that intransitive competition ('rock-paper-scissors' competition) not only promotes species richness but also fosters coexistence among highly dissimilar species with different competitive strategies...
May 15, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28808912/molecular-imaging-and-updated-diagnostic-criteria-in-lewy-body-dementias
#11
REVIEW
Nicolaas I Bohnen, Martijn L T M Müller, Kirk A Frey
PURPOSE OF REVIEW: The aims of the study were to review recent advances in molecular imaging in the Lewy body dementias (LBD) and determine if these may support the clinical but contested temporal profile distinction between Parkinson disease (PD) with dementia (PDD) versus dementia with Lewy bodies (DLB). RECENT FINDINGS: There do not appear to be major regional cerebral metabolic or neurotransmitter distinctions between PDD and DLB. However, recent studies highlight the relative discriminating roles of Alzheimer proteinopathies...
August 14, 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28807595/sphingosine-kinase-2-deficiency-ameliorates-kidney-fibrosis-by-up-regulating-smad7-in-a-mouse-model-of-unilateral-ureteral-obstruction
#12
Stephanie Schwalm, Sandra Beyer, Helena Frey, Riad Haceni, Georgios Grammatikos, Dominique Thomas, Gerd Geisslinger, Liliana Schaefer, Andrea Huwiler, Josef Pfeilschifter
Kidney fibrosis is a hallmark of chronic kidney disease and leads to extracellular matrix accumulation, organ scarring, and loss of kidney function. In this study, we investigated the role of sphingosine kinase-2 (SPHK2) on the progression of tubular fibrosis by utilizing a mouse unilateral ureteral obstruction (UUO) model. We found that SPHK2 protein and activity are up-regulated in fibrotic renal tissue. Functionally, Sphk2 deficient (Sphk2(-/-)) mice showed an attenuated fibrotic response to UUO compared to wild-type mice as demonstrated by reduced collagen abundance and decreased expression of fibronectin-1, collagen I, α-smooth muscle actin, connective tissue growth factor (CTGF), and plasminogen activator inhibitor (PAI-1)...
August 11, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28805066/active-controlled-motion-in-early-rehabilitation-improves-outcome-after-ankle-fractures-a-randomized-controlled-trial
#13
Hendrik Jansen, Martin Jordan, Sönke Frey, Stefanie Hölscher-Doht, Rainer Meffert, Timo Heintel
OBJECTIVE: To evaluate the use of active controlled motion (ACM) after unstable ankle fractures needing initial partial weight-bearing. DESIGN: Prospective randomized controlled trial. SETTING: Inpatient and outpatient clinic. SUBJECTS: A total of 50 patients with unstable ankle fractures and the need for partial weight-bearing for six weeks. INTERVENTIONS: Randomization in two groups: physiotherapy alone or physiotherapy with an additional ACM device...
August 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28803748/management-and-prognosis-of-ovarian-yolk-sac-tumors-an-analysis-of-the-national-cancer-data-base
#14
Dimitrios Nasioudis, Eloise Chapman-Davis, Melissa K Frey, Thomas A Caputo, Kevin Holcomb
OBJECTIVE: To evaluate the clinico-pathological characteristics, management and prognosis of women diagnosed with ovarian yolk sac tumors (OYSTs). METHODS: The U.S National Cancer Data Base was queried for women diagnosed with OYST between 2004 and 2014. Overall survival (OS) was calculated following generation of Kaplan-Meir curves. Univariate analysis was performed with the log-rank test. A Cox model was constructed to determine independent predictors of mortality...
August 10, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28800213/on-the-dynamics-of-additive-migration-to-form-cathodic-interlayers-in-organic-solar-cells
#15
Jane Vinokur, Stas Obuchovsky, Igal Deckman, Lishai Shoham, Tom Mates, Michael L Chabinyc, Gitti L Frey
Migration of additives to organic/metal interfaces can be used to self-generate interlayers in organic electronic devices. To generalize this approach for different additives, metals and organic electronic devices it is first necessary to study the dynamics of additive migration from the bulk to the top organic/metal interface. In this study we focus a known cathode interlayer material, polyethylene glycol (PEG), as additive in P3HT:PC71BM blends and study its migration to the blend/Al interface during metal deposition, and its effect on organic solar cell (OSC) performance...
August 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28798688/establishment-and-characterization-of-a-novel-rat-model-of-mechanical-low-back-pain-using-behavioral-pharmacologic-and-histologic-methods
#16
Arjun Muralidharan, Thomas S W Park, John T Mackie, Luiz G S Gimenez, Andy Kuo, Janet R Nicholson, Laura Corradini, Maree T Smith
Chronic low back pain (LBP), the leading cause of disability globally, is notoriously difficult to treat. Most rodent models of LBP mimic lumbar radicular pain rather than mechanical LBP. Here, we describe establishment of a new rat model of mechanical LBP that is devoid of a neuropathic component. Groups of adult male Sprague Dawley rats were anesthetized and their lumbar L4/L5 and L5/L6 intervertebral disks (IVDs) were punctured (0.5 mm outer diameter, 2mm-deep) 5 (LPB-5X), or 10 (LBP-10X) times per disk...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28798412/a-time-varying-biased-random-walk-approach-to-human-growth
#17
Béla Suki, Urs Frey
Growth and development are dominated by gene-environment interactions. Many approaches have been proposed to model growth, but most are either descriptive or describe population level phenomena. We present a random walk-based growth model capable of predicting individual height, in which the growth increments are taken from time varying distributions mimicking the bursting behaviour of observed saltatory growth. We derive analytic equations and also develop a computational model of such growth that takes into account gene-environment interactions...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28795133/performance-of-18-f-flutemetamol-amyloid-imaging-against-the-neuritic-plaque-component-of-cerad-and-the-current-2012-nia-aa-recommendations-for-the-neuropathologic-diagnosis-of-alzheimer-s-disease
#18
Stephen Salloway, Jose E Gamez, Upinder Singh, Carl H Sadowsky, Teresa Villena, Marwan N Sabbagh, Thomas G Beach, Ranjan Duara, Adam S Fleisher, Kirk A Frey, Zuzana Walker, Arvinder Hunjan, Yavir M Escovar, Marc E Agronin, Joel Ross, Andrea Bozoki, Mary Akinola, Jiong Shi, Rik Vandenberghe, Milos D Ikonomovic, Paul F Sherwin, Gill Farrar, Adrian P L Smith, Christopher J Buckley, Dietmar Rudolf Thal, Michelle Zanette, Craig Curtis
INTRODUCTION: Performance of the amyloid tracer [(18)F]flutemetamol was evaluated against three pathology standard of truth (SoT) measures including neuritic plaques (CERAD "original" and "modified" and the amyloid component of the 2012 NIA-AA guidelines). METHODS: After [(18)F]flutemetamol imaging, 106 end-of-life patients who died underwent postmortem brain examination for amyloid plaque load. Blinded positron emission tomography scan interpretations by five independent electronically trained readers were compared with pathology measures...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28794502/proteomics-phosphoproteomics-of-left-ventricular-biopsies-from-patients-with-surgical-coronary-revascularization-and-pigs-with-coronary-occlusion-reperfusion-remote-ischemic-preconditioning
#19
Nilgün Gedik, Marcus Krüger, Matthias Thielmann, Eva Kottenberg, Andreas Skyschally, Ulrich H Frey, Elke Cario, Jürgen Peters, Heinz Jakob, Gerd Heusch, Petra Kleinbongard
Remote ischemic preconditioning (RIPC) by repeated brief cycles of limb ischemia/reperfusion reduces myocardial ischemia/reperfusion injury. In left ventricular (LV) biopsies from patients undergoing coronary artery bypass grafting (CABG), only the activation of signal transducer and activator of transcription 5 was associated with RIPC's cardioprotection. We have now used an unbiased, non-hypothesis-driven proteomics and phosphoproteomics approach to analyze LV biopsies from patients undergoing CABG and from pigs undergoing coronary occlusion/reperfusion without (sham) and with RIPC...
August 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28791299/differential-microrna-analyses-of-burkholderia-pseudomallei-and-francisella-tularensis-exposed-hpbmcs-reveal-potential-biomarkers
#20
Regina Z Cer, J Enrique Herrera-Galeano, Kenneth G Frey, Kevin L Schully, Truong V Luu, John Pesce, Vishwesh P Mokashi, Andrea M Keane-Myers, Kimberly A Bishop-Lilly
Increasing evidence that microRNAs (miRNAs) play important roles in the immune response against infectious agents suggests that miRNA might be exploitable as signatures of exposure to specific infectious agents. In order to identify potential early miRNA biomarkers of bacterial infections, human peripheral blood mononuclear cells (hPBMCs) were exposed to two select agents, Burkholderia pseudomallei K96243 and Francisella tularensis SHU S4, as well as to the nonpathogenic control Escherichia coli DH5α. RNA samples were harvested at three early time points, 30, 60, and 120 minutes postexposure, then sequenced...
2017: International Journal of Genomics
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