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https://www.readbyqxmd.com/read/28932184/methods-used-to-evaluate-pain-behaviors-in-rodents
#1
Jennifer R Deuis, Lucie S Dvorakova, Irina Vetter
Rodents are commonly used to study the pathophysiological mechanisms of pain as studies in humans may be difficult to perform and ethically limited. As pain cannot be directly measured in rodents, many methods that quantify "pain-like" behaviors or nociception have been developed. These behavioral methods can be divided into stimulus-evoked or non-stimulus evoked (spontaneous) nociception, based on whether or not application of an external stimulus is used to elicit a withdrawal response. Stimulus-evoked methods, which include manual and electronic von Frey, Randall-Selitto and the Hargreaves test, were the first to be developed and continue to be in widespread use...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28930803/safety-of-fertility-sparing-surgery-for-premenopausal-women-with-sex-cord-stromal-tumors-confined-to-the-ovary
#2
Dimitrios Nasioudis, Melissa K Frey, Eloise Chapman-Davis, Steven S Witkin, Kevin Holcomb
OBJECTIVE: The aim of this retrospective population-based study was to investigate the oncologic safety of fertility-sparing surgery (FSS) for premenopausal women with malignant sex cord-stromal tumors (SCSTs) confined to the ovary. METHODS: A cohort of women aged 18 to 49 years and diagnosed with a stage I malignant SCST between 1984 and 2013 was drawn from the National Cancer Institute's Surveillance, Epidemiology, and End Results database. Based on site-specific surgery codes, women who had FSS, defined as unilateral oophorectomy/tumor resection without hysterectomy, and definite surgery were identified...
September 19, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28929420/adverse-childhood-experiences-and-child-health-outcomes-comparing-cumulative-risk-and-latent-class-approaches
#3
Paul Lanier, Kathryn Maguire-Jack, Brianna Lombardi, Joseph Frey, Roderick A Rose
Objectives This study seeks to further the work exploring adverse childhood experiences (ACEs) by proposing a novel approach to understanding the impact of ACEs through applying advanced analytical methods to examine whether combinations of ACEs differentially impact child health outcomes. Methods Using National Survey of Children's Health data, we use latent class analysis to estimate associations between classes of ACEs and child health outcomes. Results Class membership predicts child poor health, with differences found for specific ACE combinations...
September 19, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28923653/effects-of-the-mammalian-target-of-rapamycin-inhibitor-everolimus-on-hepatitis-c-virus-replication-in%C3%A2-vitro-and-in%C3%A2-vivo
#4
A Frey, E-M Ecker, K Piras-Straub, A Walker, T G Hofmann, J Timm, B B Singer, G Gerken, K Herzer
BACKGROUND: The influence of immunosuppressants on hepatitis C virus (HCV) re-infection after liver transplantation, particularly mammalian target of rapamycin inhibitors, remains unclear. The aim of our study was to analyze the influence of everolimus (EVR) on HCV replication activity in the context of underlying molecular mechanisms, with focus on the pro-myelocytic leukemia protein (PML). METHODS: HCV viral load was recorded in 40 patients with post-transplant HCV re-infection before and 8 weeks after introduction of EVR...
October 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28922189/acr-acnm-practice-parameter-for-the-performance-of-dopamine-transporter-dat-single-photon-emission-computed-tomography-spect-imaging-for-movement-disorders
#5
Rathan M Subramaniam, Kirk A Frey, Christopher H Hunt, Gustavo A Mercier, Lilja B Solnes, Patrick M Colletti, Yang Lu, Bital Savir-Baruch, Hadyn T Williams
This American College of Radiology and American College of Nuclear Medicine joint clinical practice parameter is for performance of dopamine transporter single photon emission computed tomography (SPECT) imaging, for patients with movement disorders. Parkinsonian syndrome (PS) consists of a group of neurodegenerative diseases including Parkinson disease (PD), progressive supranuclear palsy (PSP), multiple system atrophy (MSA), corticobasal degeneration (CBD), and dementia with Lewy bodies (DLB). Accurate diagnosis of PS is critical for clinical management...
September 15, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28920533/refinement-of-the-montreal-instrument-for-cat-arthritis-testing-for-use-by-veterinarians-detection-of-naturally-occurring-osteoarthritis-in-laboratory-cats
#6
Mary P Klinck, Beatriz P Monteiro, Bertrand Lussier, Martin Guillot, Maxim Moreau, Colombe Otis, Paulo Vm Steagall, Diane Frank, Johanne Martel-Pelletier, Jean-Pierre Pelletier, Jérôme Re Del Castillo, Eric Troncy
Objectives Feline osteoarthritis causes pain and disability. Detection and measurement is challenging, relying heavily on owner report. This study describes refinement of the Montreal Instrument for Cat Arthritis Testing, for Use by Veterinarians. Methods A video analysis of osteoarthritic (n = 6) and non-osteoarthritic (n = 4) cats facilitated expansion of scale items. Three successive therapeutic trials (using gabapentin, tramadol and oral transmucosal meloxicam spray) in laboratory cats with and without natural osteoarthritis (n = 12-20), permitted construct validation (assessments of disease status sensitivity and therapeutic responsiveness) and further scale refinements based on performance...
September 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28919812/the-effect-of-local-topical-analgesics-on-incisional-pain-in-a-pig-model
#7
David Castel, Itai Sabbag, Sigal Meilin
Interest in the development of new topical/local drug administration for blocking pain at peripheral sites, with maximum drug activity and minimal systemic effects, is on the rise. In the review article by Kopsky and Stahl, four critical barriers in the process of research and development of topical analgesics were indicated. The active pharmaceutical ingredient (API) and the formulation are among the major challenges. The road to the development of such drugs passes through preclinical studies. These studies, if planned correctly, should serve as guidance for choosing the right API and formulation...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28915832/dogs-as-victims-of-their-own-worms-serodiagnosis-of-canine-alveolar-echinococcosis
#8
C F Frey, N Marreros, S Renneker, L Schmidt, H Sager, B Hentrich, S Milesi, B Gottstein
BACKGROUND: Besides acting as definitive hosts for Echinococcus multilocularis, dogs can become infected by the larval form of this parasite and thereby develop life-threatening alveolar echinococcosis (AE). Although AE is a zoonotic disease, most therapeutic and diagnostic approaches have been developed for human patients. In dogs, AE is typically diagnosed in the advanced stage of the disease when the parasitic mass has already caused abdominal distension. At that stage, complete resection of the parasitic mass is often impossible, leaving a guarded prognosis for the affected dogs...
September 16, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28914784/antiallodynic-effects-of-bee-venom-in-an-animal-model-of-complex-regional-pain-syndrome-type-1-crps-i
#9
Sung Hyun Lee, Jae Min Lee, Yun Hong Kim, Jung Hyun Choi, Seung Hwan Jeon, Dong Kyu Kim, Hyeon Do Jeong, You Jung Lee, Hue Jung Park
Neuropathic pain in a chronic post-ischaemic pain (CPIP) model mimics the symptoms of complex regional pain syndrome type I (CRPS I). The administration of bee venom (BV) has been utilized in Eastern medicine to treat chronic inflammatory diseases accompanying pain. However, the analgesic effect of BV in a CPIP model remains unknown. The application of a tight-fitting O-ring around the left ankle for a period of 3 h generated CPIP in C57/Bl6 male adult mice. BV (1 mg/kg ; 1, 2, and 3 times) was administered into the SC layer of the hind paw, and the antiallodynic effects were investigated using the von Frey test and by measuring the expression of neurokinin type 1 (NK-1) receptors in dorsal root ganglia (DRG)...
September 15, 2017: Toxins
https://www.readbyqxmd.com/read/28913321/mixed-tumor-in-deep-lobe-and-versatility-of-acellular-dermal-matrix
#10
Jin Hwan Byun, Jung Soo Lim, Hye Kyung Lee
Frey's syndrome and infra-auricular depressed deformities are the ones of the most common complications that can occur after total parotidectomy. We report 1 case of pleomorphic adenoma occurred in the deep lobe that obtained good results from using acellular dermal matrix (ADM) after total parotidectomy. A 24-year-old man visited the hospital with oval shape mass in right mandibular angle which of 4 cm in size was found in the deep lobe of right parotid gland from Magnetic resonance imaging scanning and a pleomorphic adenoma was suspected...
June 2017: Arch Craniofac Surg
https://www.readbyqxmd.com/read/28911920/after-asthma-redefining-airways-diseases
#11
REVIEW
Ian D Pavord, Richard Beasley, Alvar Agusti, Gary P Anderson, Elisabeth Bel, Guy Brusselle, Paul Cullinan, Adnan Custovic, Francine M Ducharme, John V Fahy, Urs Frey, Peter Gibson, Liam G Heaney, Patrick G Holt, Marc Humbert, Clare M Lloyd, Guy Marks, Fernando D Martinez, Peter D Sly, Erika von Mutius, Sally Wenzel, Heather J Zar, Andy Bush
No abstract text is available yet for this article.
September 11, 2017: Lancet
https://www.readbyqxmd.com/read/28905280/enzymatic-synthesis-of-fucose-containing-galacto-oligosaccharides-using-%C3%AE-galactosidase-and-identification-of-novel-disaccharide-structures
#12
Anne Usvalampi, Hannu Maaheimo, Olli Tossavainen, Alexander D Frey
Fucosylated oligosaccharides have an important role in maintaining a healthy immune system and homeostatic gut microflora. This study employed a commercial β-galactosidase in the production of fucose-containing galacto-oligosaccharides (fGOS) from lactose and fucose. The production was optimized using experiment design and optimal conditions for a batch production in 3-liter scale. The reaction product was analyzed and the produced galactose-fucose disaccharides were purified. The structures of these disaccharides were determined using NMR and it was verified that one major product with the structure Galβ1-3Fuc and two minor products with the structures Galβ1-4Fuc and Galβ1-2Fuc were formed...
September 13, 2017: Glycoconjugate Journal
https://www.readbyqxmd.com/read/28904523/music-listening-among-postoperative-patients-in-the-intensive-care-unit-a-randomized-controlled-trial-with-mixed-methods-analysis
#13
Nancy Ames, Rebecca Shuford, Li Yang, Brad Moriyama, Meredith Frey, Florencia Wilson, Thiruppavai Sundaramurthi, Danelle Gori, Andrew Mannes, Alexandra Ranucci, Deloris Koziol, Gwenyth R Wallen
BACKGROUND: Music listening may reduce the physiological, emotional, and mental effects of distress and anxiety. It is unclear whether music listening may reduce the amount of opioids used for pain management in critical care, postoperative patients or whether music may improve patient experience in the intensive care unit (ICU). METHODS: A total of 41 surgical patients were randomized to either music listening or controlled non-music listening groups on ICU admission...
2017: Integrative Medicine Insights
https://www.readbyqxmd.com/read/28900803/making-decisions-about-medication-use-during-pregnancy-implications-for-communication-strategies
#14
Molly M Lynch, Linda B Squiers, Katherine M Kosa, Suzanne Dolina, Jennifer Gard Read, Cheryl S Broussard, Meghan T Frey, Kara N Polen, Jennifer N Lind, Suzanne M Gilboa, Janis Biermann
Objective To explore women's perceptions of the risks and benefits associated with medication use during pregnancy and to better understand how women make decisions related to medication use in pregnancy. Methods We conducted online focus groups with 48 women who used medication during pregnancy or while planning a pregnancy, and 12 in-depth follow-up interviews with a subset of these women. Results We found that women were aware of general risks associated with medication use but were often unable to articulate specific negative outcomes...
September 12, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28899842/identifying-which-urban-children-with-asthma-benefit-most-from-clinician-prompting-sub-analyses-from-the-pair-up-trial
#15
Nicolas P N Goldstein, Sean M Frey, Maria Fagnano, Sande O Okelo, Jill S Halterman
OBJECTIVE: Clinician prompts increase the likelihood of guideline-recommended corrective actions (preventive medication prescription, dose change, and/or adherence promotion) for symptomatic children with poorly controlled or persistent asthma in the primary care setting, but it is unclear if all children benefit equally. The objectives of this study were to identify whether asthma severity, visit type, and current preventive medication use were predictive of corrective actions during visits for children with symptomatic asthma, and determine whether these factors modified the impact of a prompting intervention...
September 9, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28899833/a-pilot-study-of-the-level-of-evidence-and-collaboration-in-published-neurosurgical-research
#16
Casey D Frey, Taylor A Wilson, Mason Decamillis, Thomas Wilson, John A Wilson, Stacey Q Wolfe, Kyle M Fargen
BACKGROUND: Large-scale studies analyzing neurosurgical published research are lacking. OBJECTIVE: This pilot study was designed to assess the feasibility of an ongoing annual neurosurgical literature and research analysis of published manuscripts in English language neurosurgery journals. METHODS: All scientific manuscripts published during 2015 in the print version of 14 English language neurosurgery journals were reviewed individually. RESULTS: A total of 4065 manuscripts were published in the 14 neurosurgical journals during 2015...
September 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28898535/characterization-of-social-cognition-impairment-in-multiple-sclerosis
#17
Mireille Neuhaus, Sara Bagutti, Özgür Yaldizli, Dominik Zwahlen, Simeon Schaub, Bettina Frey, Bettina Fischer-Barnicol, Jean-Marc Burgunder, Marie-Dominique Martory, Jana Pöttgen, Jean-Marie Annoni, Iris-Katharina Penner
BACKGROUND: Multiple sclerosis (MS) has been associated with deficits in social cognition. However, little is known about which domains of social cognition are predominantly affected and what other factors are associated with it. OBJECTIVES: 1) To characterize social cognition deficit in a group of MS outpatients. 2) To relate impairment in social cognition to overall cognitive status, depression and fatigue. METHODS: Thirty-five MS patients (mean disease duration 12...
September 12, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28894759/differential-efficiency-of-transcutaneous-electrical-nerve-stimulation-in-dominant-versus-nondominant-hands-in-fibromyalgia-placebo-controlled-functional-near-infrared-spectroscopy-study
#18
Aykut Eken, Murat Kara, Bora Baskak, Ayşegül Baltacı, Didem Gökçay
Using functional near-infrared spectroscopy (fNIRS), modulation of hemodynamic responses by transcutaneous electrical nerve stimulation (TENS) during delivery of nociceptive stimulation was investigated in fibromyalgia (FM) patients and healthy controls for both hands. Two experiments were conducted: (1) median nerve stimulation with TENS and (2) painful stimulation using electronic von Frey filaments with TENS/placebo TENS. Mean [Formula: see text] brain activity was compared across groups and conditions using factorial ANOVA...
January 2018: Neurophotonics
https://www.readbyqxmd.com/read/28894670/reply-what-is-the-ideal-neophallus-response-to-frey-et-al-2017-an-update-on-genital-reconstruction-options-for-the-female-to-male-transgender-patient-a-review-of-the-literature
#19
Jordan D Frey, Grace Poudrier, Michael V Chiodo, Alexes Hazen
No abstract text is available yet for this article.
August 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28894669/what-is-the-ideal-neophallus-response-to-frey-et-al-2017-an-update-on-genital-reconstruction-options-for-the-female-to-male-transgender-patient-a-review-of-the-literature
#20
Lian Elfering, Mujde Özer, Marlon E Buncamper, Jan-Maerten Smit, Garry L S Pigot, Mark Bram Bouman, Margriet G Mullender
No abstract text is available yet for this article.
August 2017: Plastic and Reconstructive Surgery. Global Open
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