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https://www.readbyqxmd.com/read/28941361/hepatitis-c-virus-testing-for-case-identification-in-persons-born-during-1945-1965-results-from-three-randomized-controlled-trials
#1
Anthony K Yartel, David B Rein, Kimberly Ann Brown, Katherine Krauskopf, Omar I Massoud, Cynthia Jordan, Natalie Kil, Alex D Federman, David R Nerenz, Joanne E Brady, Danielle L Kruger, Bryce D Smith
CDC and U.S. Preventive Services Task Force recommend one-time hepatitis C virus (HCV) testing for persons born during 1945-1965 (birth cohort). However, few studies estimate the effect of birth cohort (BC) testing implementation on HCV diagnoses in primary care settings. We aimed to determine the probability of identifying HCV infections in primary care using targeted BC testing compared with usual care at three academic medical centers. From December 2012 to March 2014, each center compared one of three distinct interventions to usual care using an independently-designed randomized controlled trial...
September 23, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28938488/ovarian-aging-in-women-with-brca-germline-mutations
#2
Wayne Lin, Shiny Titus, Fred Moy, Elizabeth S Ginsburg, Kutluk Oktay
Context: Recent clinical and laboratory studies suggested that women with BRCA mutations have lower ovarian reserve and their primordial follicle oocytes may be more prone to DNA damage but the direct proof is lacking. Objective: To determine whether women with germline BRCA mutations have reduced primordial follicle reserve and increased oocyte DNA damage. Design: A laboratory comparative study of ovarian tissue obtained from the risk-reducing salpingo- oophorectomy (RRSO) samples of unaffected BRCA mutation carrier (BMC) women vs...
August 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938435/the-role-of-sequential-bmp-signaling-in-directing-human-embryonic-stem-cells-to-bipotential-gonadal-cells
#3
Kirsi Sepponen, Karolina Lundin, Katri Knuus, Pia Väyrynen, Taneli Raivio, Juha S Tapanainen, Timo Tuuri
Context: Human gonads arise as a pair of epithelial ridges on the surface of intermediate mesoderm (IM)-derived mesonephros. Toxic environmental factors and mutations in various genes are known to disturb normal gonadal development, but due to a lack of suitable in vitro models, detailed studies characterizing the molecular basis of the observed defects have not been performed. Objective: Our objective was to establish an in vitro method for studying differentiation of bipotential gonadal progenitors using human embryonic stem cells (hESCs), and to investigate the role of bone morphogenetic protein (BMP) in gonadal differentiation...
August 29, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938413/prenatal-diagnosis-of-resistance-to-thyroid-hormone-and-its-clinical-implications
#4
Theodora Pappa, João Anselmo, Sunnee Mamanasiri, Alexandra M Dumitrescu, Roy E Weiss, Samuel Refetoff
Context: Resistance to thyroid hormone beta (RTHβ) is an autosomal dominant disorder characterized by reduced sensitivity of target tissues to thyroid hormones (TH). Individuals with RTHβ have high TH levels usually due to mutations in the TH receptor beta (THRB) gene. The management of RTHβ during pregnancy is challenging as wild-type (WT) fetuses born to RTHβ mothers have low birth weight and suppressed postnatal TSH, due to intrauterine exposure to excess TH. Objective: To determine birth weight and postnatal TSH of WT fetuses carried by mothers with RTHβ whose fT4 levels were maintained below 20% the upper limit of normal (ULN)...
August 4, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938356/the-importance-of-an-academic-approach-to-patient-oriented-aesthetic-outcome-research-reply-to-comment-on-validating-facial-aesthetic-surgery-results-with-the-face-q
#5
E A Kappos, M Tremp, D J Schaefer, Kristin M Schaefer, M Haug, D F Kalbermatten, B A Toth
No abstract text is available yet for this article.
September 16, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28938234/is-early-total-care-a-safe-and-effective-alternative-to-staged-protocol-for-the-treatment-of-schatzker-iv-vi-tibial-plateau-fractures-in-patients-older-than-50-years
#6
Amrut Borade, Harish Kempegowda, Raveesh Richard, Jove Graham, Michael Suk, Daniel S Horwitz
OBJECTIVES: To compare "Early Total Care" (ETC) with "Staged Protocol" (SP) for the treatment of Schatzker IV-VI tibial plateau fractures in patients older than 50 years regarding safety and effectiveness. DESIGN: Retrospective cohort study. SETTING: An academic level 1 US trauma center. PATIENTS/PARTICIPANTS: Eighty-one patients older than 50 years with Schatzker grade IV-VI tibial plateau fractures were included. INTERVENTION: Fifty-three patients were treated under SP with immediate external fixation followed by definitive internal fixation...
September 19, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28937900/parents-attitude-towards-the-use-of-fluorides-and-fissure-sealants-and-its-effect-on-their-children-s-oral-health
#7
Sigalit Blumer, Tal Ratson, Benjamin Peretz, Nurit Dagon
OBJECTIVES: To characterize the attitudes of Israeli parents towards caries preventive measures. STUDY DESIGN: participating parents completed a 21-item questionnaire on their demographics, dental history, attitudes and satisfaction from fluorides and fissure sealants. RESULTS: One hundred parents (average age 41.62±4.9 years, 85 females) participated. Most of the parents (88% of the mothers and 84% of the fathers) had an academic education...
September 22, 2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28937802/epidemiology-of-stress-fractures-in-collegiate-student-athletes-2004-2005-through-2013-2014-academic-years
#8
Katherine H Rizzone, Kathryn E Ackerman, Karen G Roos, Thomas P Dompier, Zachary Y Kerr
CONTEXT:   Stress fractures are injuries caused by cumulative, repetitive stress that leads to abnormal bone remodeling. Specific populations, including female athletes and endurance athletes, are at higher risk than the general athletic population. Whereas more than 460 000 individuals participate in collegiate athletics in the United States, no large study has been conducted to determine the incidence of stress fractures in collegiate athletes. OBJECTIVE:   To assess the incidence of stress fractures in National Collegiate Athletic Association (NCAA) athletes and investigate rates and patterns overall and by sport...
September 22, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28937790/the-doctor-of-philosophy-experience-of-athletic-trainers-facilitators-and-barriers-to-anticipatory-faculty-socialization
#9
Thomas Bowman, Joanne Klossner, Stephanie Mazerolle
CONTEXT:   It is important to understand the process whereby athletic trainers learn about their future roles, particularly when the roles can be complex and demanding. Little is known about the experiences of athletic training doctoral students, including facilitators and barriers to socialization as aspiring faculty members. OBJECTIVE:   To investigate factors influencing the anticipatory socialization of athletic training doctoral students into future faculty roles...
September 22, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28937789/identifying-dyslexia-risk-in-student-athletes-a-preliminary-protocol-for-concussion-management
#10
Rebecca Wiseheart, Robin Wellington
Learning disability (LD) has been identified as a potential risk factor for protracted recovery from a sport-related concussion, yet students with LD are rarely included in concussion research. Here, we draw special attention to dyslexia, a common but often underdiagnosed LD. Reading and learning problems commonly associated with dyslexia are often masked by protective factors, such as high verbal ability or general intelligence. Hence, high-achieving individuals with dyslexia may not be identified as being in a high-risk category...
September 22, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28937730/dr-ajit-sachdeva-takes-helm-of-the-society-for-academic-continuing-medical-education
#11
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Bulletin of the American College of Surgeons
https://www.readbyqxmd.com/read/28937548/a-follow-up-study-of-electroconvulsive-therapy-in-children-and-adolescents
#12
Shanti Mitchell, Ehmer Hassan, Neera Ghaziuddin
OBJECTIVES: Electroconvulsive therapy (ECT) is an effective and a safe treatment for several severe psychiatric disorders across the age span. However, its use remains controversial and highly stigmatized especially among patients under 18 years. In this study, we examined current symptoms, attitudes, perception, and functioning of patients treated with ECT when they were less than 18 years old. METHODS: Participants had received ECT before age 18, between 1989 and 2015, at a tertiary medical center...
September 20, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28937517/effects-of-a-short-video-based-resident-as-teacher-training-toolkit-on-resident-teaching
#13
Hope A Ricciotti, Taylor S Freret, Ashley Aluko, Bri Anne McKeon, Miriam J Haviland, Lori R Newman
OBJECTIVE: To pilot a short video-based resident-as-teacher training toolkit and assess its effect on resident teaching skills in clinical settings. METHODS: A video-based resident-as-teacher training toolkit was previously developed by educational experts at Beth Israel Deaconess Medical Center, Harvard Medical School. Residents were recruited from two academic hospitals, watched two videos from the toolkit ("Clinical Teaching Skills" and "Effective Clinical Supervision"), and completed an accompanying self-study guide...
October 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28937512/obstetricians-and-gynecologists-of-the-future-a-survey-of-medical-students-applying-to-residency
#14
Meredith J Alston, Amy Meg Autry, Sarah A Wagner, Abigail Winkel, Amanda A Allshouse, Alyssa Stephenson-Famy
OBJECTIVE: To understand the characteristics and career goals of medical students selecting a career in obstetrics and gynecology. METHODS: In 2015-2016, medical students invited for interviews for obstetrics and gynecology residency at the University of Colorado, University of Washington, University of California San Francisco, Loyola University, and New York University received a voluntary 20-item electronic survey regarding factors influencing their choice of medical specialty...
October 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28937497/cognitive-skills-training-for-homeless-transition-age-youth-feasibility-and-pilot-efficacy-of-a-community-based-randomized-controlled-trial
#15
Alice Medalia, Alice M Saperstein, Yanlan Huang, Seonjoo Lee, Elizabeth J Ronan
Cognitive impairments are common in homeless youth and negatively impact academic and vocational outcomes. We examined the feasibility and efficacy of cognitive interventions provided to 18- to 22-year-old homeless youth living in urban supportive housing. Ninety-one homeless youth were randomized to receive either targeted cognitive training (cognitive remediation) or general cognitive activation (computer skills training). Cognitive and psychological outcomes were assessed at baseline, after 13 and 26 sessions, and 1 month postintervention...
September 20, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28937454/life-expectancy-and-metastatic-spine-scoring-systems-an-academic-institutional-experience
#16
Brian T Ragel, Gustavo A Mendez, Justin Reddington, David Ferachi, Charlotte D Kubicky, Travis C Philipp, Natalie L Zusman, Paul Klimo, Robert Hart, Jung Yoo, Alex C Ching
STUDY DESIGN: A retrospective data collection study with application of metastatic spine scoring systems. OBJECTIVES: To apply the Tomita and revised Tokuhashi scoring systems to a surgical cohort at a single academic institution and analyze spine-related surgical morbidity and mortality rates. SUMMARY OF BACKGROUND DATA: Surgical management of metastatic spine patients requires tools that can accurately predict patient survival, as well as knowledge of morbidity and mortality rates...
October 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28937039/safety-and-necessity-of-antiplatelet-therapy-on-patients-underwent-endovascular-aortic-repair-with-both-stanford-type-b-aortic-dissection-and-coronary-heart-disease
#17
Rui-Xia He, Lei Zhang, Tie-Nan Zhou, Wen-Jie Yuan, Yan-Jie Liu, Wen-Xia Fu, Quan-Min Jing, Hai-Wei Liu, Xiao-Zeng Wang
BACKGROUND: Acute aortic dissection is known as the most dangerous aortic disease, with management and prognosis determined as the disruption of the medial layer provoked by intramural bleeding. The objective of this study was to evaluate the safety and necessity of antiplatelet therapy on patients with Stanford Type B aortic dissection (TBAD) who underwent endovascular aortic repair (EVAR). METHODS: The present study retrospectively analyzed 388 patients with TBAD who underwent EVAR and coronary angiography...
October 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28936940/-doctor-is-my-mother-suffering-from-dementia
#18
P Scheltens, F Gillissen, F H Bouwman, W M van der Flier
- The Netherlands health service features a stepwise diagnostic course in primary, secondary and tertiary care. In the diagnostic process for dementia the patient can go to the general practitioner, then to one of the 100 memory clinics and finally to one of the 4 academic Alzheimer centres.- The diagnostic process for dementia is described in the care practice guideline 'Dementia', the NHG (Dutch College of General Practitioners) practice guideline 'Dementia' and the multidisciplinary guideline 'Dementia diagnostics'...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28936929/holding-firm-power-push-back-and-opportunities-in-navigating-the-liminal-space-of-critical-qualitative-health-research
#19
Corinne Hart, Jennifer M Poole, Marcia E Facey, Janet A Parsons
Critical qualitative health researchers typically occupy and navigate liminal academic spaces and statuses, with one foot planted in the arts and social sciences and the other in biomedical science. We are at once marginalized and empowered, and this liminality presents both challenges and opportunities. In this article, we draw on our experiences of being (often the lone) critical qualitative health scholars on thesis advisory committees and dissertation examinations, as well as our experiences of publishing and securing funding, to illuminate how power and knowledge relations create conditions that shape the nature of our roles...
October 2017: Qualitative Health Research
https://www.readbyqxmd.com/read/28936855/-investigation-on-supramolecular-mechanism-of-multi-component-overall-control-in-chinese-medicine-controlled-sustained-release-preparation
#20
Yan-Tao Yang, Ye-Qin Tao, Wen-Han Tang, Sen Li, Ji-Lian Shi, Yi-Qun Zhou, Wen-Long Liu, Fu-Yuan He
Controlled sustained-release preparation (CSRP) is a definitely important source of innovative medicines, however, its further researches and development are limited due to the complexity of Chinese medicine (CM) compositions, and a series of unclear key problems like the apparent properties from physical and chemical aspects. Combined with the CM characteristics of the multiple components and synergistic effect, a series of bottleneck problems in the preparation of CSRP were analyzed. Then the mechanism and influences of supermolecular chemical theory in the CSRP about the multiple-components overall-control were explored under the guideline of "overall control, synchronous dissolution" in CSRP, based on the previous explications about supramolecular chemistry theories and with the application of single component precision controlling technologies...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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