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https://www.readbyqxmd.com/read/28634399/terrestrial-water-load-and-groundwater-fluctuation-in-the-bengal-basin
#1
W G Burgess, M Shamsudduha, R G Taylor, A Zahid, K M Ahmed, A Mukherjee, D J Lapworth, V F Bense
Groundwater-level fluctuations represent hydraulic responses to changes in groundwater storage due to aquifer recharge and drainage as well as to changes in stress that include water mass loading and unloading above the aquifer surface. The latter 'poroelastic' response of confined aquifers is a well-established phenomenon which has been demonstrated in diverse hydrogeological environments but is frequently ignored in assessments of groundwater resources. Here we present high-frequency groundwater measurements over a twelve-month period from the tropical, fluvio-deltaic Bengal Aquifer System (BAS), the largest aquifer in south Asia...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28631859/determining-the-drivers-of-population-structure-in-a-highly-urbanized-landscape-to-inform-conservation-planning
#2
Henri A Thomassen, Ryan J Harrigan, Kathleen Semple Delaney, Seth P D Riley, Laurel E K Serieys, Katherine Pease, Robert K Wayne, Thomas B Smith
Understanding the environmental contributors to population structure is of paramount importance for conservation in urbanized environments. We used spatially-explicit models to determine genetic population structure under current and future environmental conditions across a highly fragmented, human-dominated environment in Southern California to assess the effects of natural ecological variation and urbanization. We focused on seven common species with diverse habitat requirements, home range sizes, and dispersal abilities...
June 20, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/28631436/characterization-of-a-novel-p110%C3%AE-specific-inhibitor-bl140-that-overcomes-mdv3100-resistance-in-castration-resistant-prostate-cancer-cells
#3
Chenchen He, Shaofeng Duan, Liang Dong, Yifen Wang, Qingting Hu, Chunjing Liu, Marcus L Forrest, Jeffrey M Holzbeierlein, Suxia Han, Benyi Li
BACKGROUND: Our previous studies demonstrated that the class IA PI3K/p110β is critical in castration-resistant progression of prostate cancer (CRPC) and that targeting prostate cancer with nanomicelle-loaded p110β-specific inhibitor TGX221 blocked xenograft tumor growth in nude mice, confirming the feasibility of p110β-targeted therapy for CRPCs. To improve TGX221's aqueous solubility, in this study, we characterized four recently synthesized TGX221 analogs. METHODS: TGX221 analog efficacy were examined in multiple prostate cancer cell lines with the SRB cell growth assay, Western blot assay for AKT phosphorylation and cell cycle protein levels...
June 20, 2017: Prostate
https://www.readbyqxmd.com/read/28631344/evaluation-of-the-genetic-structure-of-sika-deer-cervus-nippon-in-japan-s-kanto-and-tanzawa-mountain-areas-based-on-microsatellite-markers
#4
Sayaka Konishi, Shoko Hata, Sayumi Matsuda, Kazushi Arai, Yasushi Mizoguchi
The browsing habits of sika deer (Cervus nippon) in Japan have caused serious ecological problems. Appropriate management of sika deer populations requires understanding the different genetic structures of local populations. In the present study, we used 10 microsatellite polymorphisms to explore the genetic structures of sika deer populations (162 individuals) living in the Kanto region. The expected heterozygosity of the Tanzawa mountain range population (Group I) was lower than that of the populations in the Kanto mountain areas (Group II)...
June 19, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28628820/river-flow-is-critical-for-vegetation-dynamics-lessons-from-multi-scale-analysis-in-a-hyper-arid-endorheic-basin
#5
Qin Shen, Guangyao Gao, Yihe Lü, Shuai Wang, Xiaohui Jiang, Bojie Fu
Knowledge of the spatio-temporal responses of vegetation dynamics to hydro-climatic factors is important to assess ecological restoration efforts in arid and semiarid areas. In this study, the vegetation dynamics during 2000-2015 were investigated in the downstream area of the Heihe River Basin (HRB) in Northwest China where an ecological water diversion project (EWDP) commenced in 2000. The spatio-temporal relationships between vegetation cover and climatic factors (precipitation and temperature) and available water resources (river flow and groundwater) were determined...
June 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28626905/genome-architecture-enables-local-adaptation-of-atlantic-cod-despite-high-connectivity
#6
Julia M I Barth, Paul R Berg, Per R Jonsson, Sara Bonanomi, Hanna Corell, Jakob Hemmer-Hansen, Kjetill S Jakobsen, Kerstin Johannesson, Per Erik Jorde, Halvor Knutsen, Per-Olav Moksnes, Bastiaan Star, Nils Chr Stenseth, Henrik Svedäng, Sissel Jentoft, Carl André
Adaptation to local conditions is a fundamental process in evolution; however, mechanisms maintaining local adaptation despite high gene flow are still poorly understood. Marine ecosystems provide a wide array of diverse habitats that frequently promote ecological adaptation even in species characterized by strong levels of gene flow. As one example, populations of the marine fish Atlantic cod (Gadus morhua) are highly connected due to immense dispersal capabilities but nevertheless show local adaptation in several key traits...
June 19, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28620783/advanced-neuroimaging-of-cerebral-small-vessel-disease
#7
REVIEW
Gordon W Blair, Maria Valdez Hernandez, Michael J Thrippleton, Fergus N Doubal, Joanna M Wardlaw
Cerebral small vessel disease (SVD) is characterised by damage to deep grey and white matter structures of the brain and is responsible for a diverse range of clinical problems that include stroke and dementia. In this review, we describe advances in neuroimaging published since January 2015, mainly with magnetic resonance imaging (MRI), that, in general, are improving quantification, observation and investigation of SVD focussing on three areas: quantifying the total SVD burden, imaging brain microstructural integrity and imaging vascular malfunction...
July 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28620037/the-more-the-merrier-high-throughput-single-molecule-techniques
#8
REVIEW
Flynn R Hill, Enrico Monachino, Antoine M van Oijen
The single-molecule approach seeks to understand molecular mechanisms by observing biomolecular processes at the level of individual molecules. These methods have led to a developing understanding that for many processes, a diversity of behaviours will be observed, representing a multitude of pathways. This realisation necessitates that an adequate number of observations are recorded to fully characterise this diversity. The requirement for large numbers of observations to adequately sample distributions, subpopulations, and rare events presents a significant challenge for single-molecule techniques, which by their nature do not typically provide very high throughput...
June 15, 2017: Biochemical Society Transactions
https://www.readbyqxmd.com/read/28619735/the-evolving-role-of-succinate-in-tumor-metabolism-an-18-f-fdg-based-study
#9
Philippe Garrigue, Aurore Bodin-Hullin, Laure Balasse, Samantha Fernandez, Wassim Essamet, Françoise Dignat-George, Karel Pacak, Benjamin Guillet, David Taieb
Objective: In recent years, inherited and acquired mutations in the TCA cycle enzymes have been reported in diverse cancers. Pheochromocytomas and paragangliomas (PPGLs) often exhibit dysregulation of glucose metabolism which is also driven by mutations in genes encoding the TCA cycle enzymes or by activation of hypoxia signaling. PPGLs associated with succinate dehydrogenase (SDH) deficiency are characterized by high (18)F-fluorodeoxyglucose ([(18)F]-FDG) avidity. This association is currently only partially explained...
June 15, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28617836/molecular-diversity-and-frequency-of-the-diarrheagenic-enteric-protozoan-giardia-duodenalis-and-cryptosporidium-spp-in-a-hospital-setting-in-northern-spain
#10
José Manuel Azcona-Gutiérrez, Aida de Lucio, Marta Hernández-de-Mingo, Concepción García-García, Luis Miguel Soria-Blanco, Lucía Morales, María Aguilera, Isabel Fuentes, David Carmena
BACKGROUND: Human giardiosis and cryptosporidiosis are caused by the enteric protozoan parasites Giardia duodenalis and Cryptosporidium spp. Both pathogens are major contributors to the global burden of diarrhoeal disease, affecting primarily children and immunodebilitated individuals in resource-poor settings. Giardiosis and cryptosporidiosis also represent an important, often underestimate, public health threat in developed countries. In Spain only limited information is currently available on the epidemiology of these infections...
2017: PloS One
https://www.readbyqxmd.com/read/28616068/genetic-diversity-and-structure-of-lolium-perenne-ssp-multiflorum-in-california-vineyards-and-orchards-indicate-potential-for-spread-of-herbicide-resistance-via-gene-flow
#11
Elizabeth Karn, Marie Jasieniuk
Management of agroecosystems with herbicides imposes strong selection pressures on weedy plants leading to the evolution of resistance against those herbicides. Resistance to glyphosate in populations of Lolium perenne L. ssp. multiflorum is increasingly common in California, USA, causing economic losses and the loss of effective management tools. To gain insights into the recent evolution of glyphosate resistance in L. perenne in perennial cropping systems of northwest California and to inform management, we investigated the frequency of glyphosate resistance and the genetic diversity and structure of 14 populations...
July 2017: Evolutionary Applications
https://www.readbyqxmd.com/read/28616062/severe-consequences-of-habitat-fragmentation-on-genetic-diversity-of-an-endangered-australian-freshwater-fish-a-call-for-assisted-gene-flow
#12
Alexandra Pavlova, Luciano B Beheregaray, Rhys Coleman, Dean Gilligan, Katherine A Harrisson, Brett A Ingram, Joanne Kearns, Annika M Lamb, Mark Lintermans, Jarod Lyon, Thuy T T Nguyen, Minami Sasaki, Zeb Tonkin, Jian D L Yen, Paul Sunnucks
Genetic diversity underpins the ability of populations to persist and adapt to environmental changes. Substantial empirical data show that genetic diversity rapidly deteriorates in small and isolated populations due to genetic drift, leading to reduction in adaptive potential and fitness and increase in inbreeding. Assisted gene flow (e.g. via translocations) can reverse these trends, but lack of data on fitness loss and fear of impairing population "uniqueness" often prevents managers from acting. Here, we use population genetic and riverscape genetic analyses and simulations to explore the consequences of extensive habitat loss and fragmentation on population genetic diversity and future population trajectories of an endangered Australian freshwater fish, Macquarie perch Macquaria australasica...
July 2017: Evolutionary Applications
https://www.readbyqxmd.com/read/28613379/restoration-over-time-and-sustainability-of-schinus-terebinthifolius-raddi
#13
S V Álvares-Carvalho, R Silva-Mann, I B Gois, M F V Melo, A S Oliveira, R A Ferreira, L J Gomes
The success of recovery programs on degraded areas is dependent on the genetic material to be used, which should present heterozygosity and genetic diversity in native and recovered populations. This study was carried out to evaluate the model efficiency to enable the recovery of a degraded area of the Lower São Francisco, Sergipe, Brazil. The target species for this study was Schinus terebinthifolius Raddi. Three populations were analyzed, the recovered area, seed-tree source population, and native tree population border established to the recovered area...
May 31, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28612479/open-water-and-under-ice-seasonal-variations-in-trace-element-content-and-physicochemical-associations-in-fluvial-bed-sediment
#14
Lorne E Doig, Meghan K Carr, Anna G N Meissner, Tim D Jardine, Paul D Jones, Lalita Bharadwaj, Karl-Erich Lindenschmidt
Across the circumpolar world, intensive anthropogenic activities in the southern reaches of many large, northward-flowing rivers can cause sediment contamination in the downstream depositional environment. The influence of ice cover on concentrations of inorganic contaminants in bed sediment (i.e., sediment quality) is unknown in these rivers where winter is the dominant season. A Geomorphic Response Unit (GRU) approach was used to select hydraulically-diverse sampling sites across a northern test-case system, the Slave River and Delta, NT, Canada...
June 13, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28611839/utilization-of-a-novel-multi-durometer-intracranial-distal-access-catheter-nuances-and-experience-in-110-consecutive-cases-of-aneurysm-flow-diversion
#15
Geoffrey P Colby, Li-Mei Lin, Risheng Xu, Narlin Beaty, Matthew T Bender, Bowen Jiang, Judy Huang, Rafael J Tamargo, Alexander L Coon
BACKGROUND: Coaxial catheter support systems provide a safe and stable foundation in endovascular treatment of intracranial aneurysms. Increasingly, robust distal intracranial support is sought during complex neurointerventions. The AXS Catalyst 5 distal access catheter (Cat5) is a new intracranial catheter designed for improved trackability and stability. We report the first experience using Cat5 for aneurysm treatment by flow diversion. METHODS: A single-center aneurysm database was reviewed for cases of aneurysm treatment with the Pipeline embolization device (PED) that utilized Cat5...
March 2017: Interventional Neurology
https://www.readbyqxmd.com/read/28611831/salvage-of-herniated-flow-diverters-using-stent-and-balloon-anchoring-techniques-a-technical-note
#16
Bharathi D Jagadeesan, Divyajot Sandhu, Kim Jae Hong, Sara Roshan Khanipour, Andrew W Grande, Ramachandra P Tummala
BACKGROUND: The pipeline embolization device (PED; Medtronic, MN, USA) can sometimes herniate into the aneurysmal sac in an unexpected manner during or shortly after its deployment due to device foreshortening. In this report, we describe 2 endovascular techniques, which can be used to reposition a herniated PED construct into a more favorable alignment. SUMMARY: In a 67-year-old patient who had an intraprocedural herniation of a PED device into a giant cavernous aneurysm, a stent anchor technique was used to reverse the herniation, reorient the PED construct, and achieve successful flow diversion...
March 2017: Interventional Neurology
https://www.readbyqxmd.com/read/28611408/phylogeography-of-petrolisthes-armatus-an-invasive-species-with-low-dispersal-ability
#17
Alexandra Hiller, Harilaos A Lessios
Theoretically, species with high population structure are likely to expand their range, because marginal populations are free to adapt to local conditions; however, meta-analyses have found a negative relation between structure and invasiveness. The crab Petrolisthes armatus has a wide native range, which has expanded in the last three decades. We sequenced 1718 bp of mitochondrial DNA from native and recently established populations to determine the population structure of the former and the origin of the latter...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28611073/population-genetic-structure-of-the-rock-outcrop-species-encholirium-spectabile-bromeliaceae-the-role-of-pollination-vs-seed-dispersal-and-evolutionary-implications
#18
Rodrigo C Gonçalves-Oliveira, Tina Wöhrmann, Ana M Benko-Iseppon, Florian Krapp, Marccus Alves, Maria das Graças L Wanderley, Kurt Weising
PREMISE OF THE STUDY: Inselbergs are terrestrial, island-like rock outcrop environments that present a highly adapted flora. The epilithic bromeliad Encholirium spectabile is a dominant species on inselbergs in the Caatinga of northeastern Brazil. We conducted a population genetic analysis to test whether the substantial phenotypic diversity of E. spectabile could be explained by limited gene flow among populations and to assess the relative impact of pollen vs. seed dispersal on the genetic structure of the species...
June 13, 2017: American Journal of Botany
https://www.readbyqxmd.com/read/28610970/internal-maxillary-artery-bypass-with-radial-artery-graft-treatment-of-giant-intracranial-aneurysms
#19
Long Wang, Shuaibin Lu, Hai Qian, Xiang'en Shi
BACKGROUND: Giant intracranial aneurysms (GIAs) can be approached via microsurgical and endovascular techniques. Utilization of flow diversion devices (FDDs) has yielded favorable outcomes, and indications for cerebral revascularization have dramatically decreased. OBJECTIVE: To evaluate the safety and validity of using internal maxillary artery (IMA) bypass with an interposed graft to treat GIAs. METHODS: During a 6-year period, high-flow IMA bypass procedures were performed in 32 patients with GIAs at our institute...
June 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28609989/freshwater-fishes-of-northern-australia
#20
Bradley J Pusey, Damien W Burrows, Mark J Kennard, Colton N Perna, Peter J Unmack, Quentin Allsop, Michael P Hammer
Northern Australia is biologically diverse and of national and global conservation signicance. Its ancient landscape contains the world's largest area of savannah ecosystem in good ecological condition and its rivers are largely free-flowing. Agriculture, previously confined largely to open range-land grazing, is set to expand in extent and to focus much more on irrigated cropping and horticulture. Demands on the water resources of the region are thus, inevitably increasing. Reliable information is required to guide and inform development and help plan for a sustainable future for the region which includes healthy rivers that contain diverse fish assemblages...
April 11, 2017: Zootaxa
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