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https://www.readbyqxmd.com/read/29679714/population-genetics-phylogenomics-and-hybrid-speciation-of-juglans-in-china-determined-from-whole-chloroplast-genomes-transcriptomes-and-genotyping-by-sequencing-gbs
#1
Peng Zhao, Hui-Juan Zhou, Daniel Potter, Yi-Heng Hu, Xiao-Jia Feng, Meng Dang, Li Feng, Saman Zulfiqar, Wen-Zhe Liu, Guifang Zhao, Keith Woeste
Genomic data are a powerful tool for elucidating the processes involved in the evolution and divergence of species. The speciation and phylogenetic relationships among Chinese Juglans remain unclear. Here, we used results from phylogenomic and population genetic analyses, transcriptomics, Genotyping-By-Sequencing (GBS), and whole chloroplast genomes (Cp genome) data to infer processes of lineage formation among the five native Chinese species of the walnut genus (Juglans, Juglandaceae), a widespread, economically important group...
April 18, 2018: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29678573/long-non-protein-coding-rna-dancr-functions-as-a-competing-endogenous-rna-to-regulate-osteoarthritis-progression-via-mir-577-sphk2-axis
#2
Xiaochen Fan, Jishan Yuan, Jun Xie, Zhanpeng Pan, Xiang Yao, Xiangyi Sun, Pin Zhang, Lei Zhang
Long noncoding RNAs (lncRNAs) have been known to be involved in multiple diverse diseases, including osteoarthritis (OA). This study aimed to explore the role of differentiation antagonizing non-protein coding RNA (DANCR) in OA and identify the potential molecular mechanisms. The expression of DANCR in cartilage samples from patients with OA was detected using quantitative reverse transcription-polymerase chain reaction. The effects of DANCR on the viability of OA chondrocytes and apoptosis were explored using cell counting kit 8 assay and flow cytometry assay, respectively...
April 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29678354/actin-dynamics-at-focal-adhesions-a-common-endpoint-and-putative-therapeutic-target-for-proteinuric-kidney-diseases
#3
REVIEW
Sanja Sever, Mario Schiffer
Proteinuria encompasses diverse causes including both genetic diseases and acquired forms such as diabetic and hypertensive nephropathy. The basis of proteinuria is a disturbance in size selectivity of the glomerular filtration barrier, which largely depends on the podocyte: a terminally differentiated epithelial cell type covering the outer surface of the glomerulus. Compromised podocyte structure is one of the earliest signs of glomerular injury. The phenotype of diverse animal models and podocyte cell culture firmly established the essential role of the actin cytoskeleton in maintaining functional podocyte structure...
April 17, 2018: Kidney International
https://www.readbyqxmd.com/read/29677567/methods-for-assessing-mitochondrial-quality-control-mechanisms-and-cellular-consequences-in-cell-culture
#4
Matthew Redmann, Gloria A Benavides, Willayat Yousuf Wani, Taylor F Berryhill, Xiaosen Ouyang, Michelle S Johnson, Saranya Ravi, Kasturi Mitra, Stephen Barnes, Victor M Darley-Usmar, Jianhua Zhang
Mitochondrial quality is under surveillance by autophagy, the cell recycling process which degrades and removes damaged mitochondria. Inadequate autophagy results in deterioration in mitochondrial quality, bioenergetic dysfunction, and metabolic stress. Here we describe in an integrated work-flow to assess parameters of mitochondrial morphology, function, mtDNA and protein damage, metabolism and autophagy regulation to provide the framework for a practical assessment of mitochondrial quality. This protocol has been tested with cell cultures, is highly reproducible, and is adaptable to studies when cell numbers are limited, and thus will be of interest to researchers studying diverse physiological and pathological phenomena in which decreased mitochondrial quality is a contributory factor...
April 10, 2018: Redox Biology
https://www.readbyqxmd.com/read/29675468/decline-of-genetic-diversity-in-ancient-domestic-stallions-in-europe
#5
Saskia Wutke, Edson Sandoval-Castellanos, Norbert Benecke, Hans-Jürgen Döhle, Susanne Friederich, Javier Gonzalez, Michael Hofreiter, Lembi Lõugas, Ola Magnell, Anna-Sapfo Malaspinas, Arturo Morales-Muñiz, Ludovic Orlando, Monika Reissmann, Alexandra Trinks, Arne Ludwig
Present-day domestic horses are immensely diverse in their maternally inherited mitochondrial DNA, yet they show very little variation on their paternally inherited Y chromosome. Although it has recently been shown that Y chromosomal diversity in domestic horses was higher at least until the Iron Age, when and why this diversity disappeared remain controversial questions. We genotyped 16 recently discovered Y chromosomal single-nucleotide polymorphisms in 96 ancient Eurasian stallions spanning the early domestication stages (Copper and Bronze Age) to the Middle Ages...
April 2018: Science Advances
https://www.readbyqxmd.com/read/29674079/a-comparison-study-on-the-use-of-dowex-1-and-teva-resin-in-determination-of-99-tc-in-environmental-and-nuclear-coolant-samples-in-a-sia-system-with-icp-ms-detection
#6
Kamila Kołacińska, Zbigniew Samczyński, Jakub Dudek, Anna Bojanowska-Czajka, Marek Trojanowicz
This work refers to a comparative study of sorbents widely used in determinations of 99 Tc such as TEVA resin and Dowex 1. Despite having a similar functional group of quaternary amines, both materials represent different chromatographic methods-extraction (TEVA resin) and anion exchange (Dowex 1)-which provides a diverse range of their properties significant in determination of 99 Tc in flow conditions. The comparative tests, carried out in a SIA-LOV (Sequential Injection Analysis-Lab-on-Valve) system combined with mass spectrometric (ICP-MS) detection, considered several factors that are crucial from the standpoint of resin´s utility such as sorption capacity, durability, or selectivity, critical in 99 Tc separation from interferences...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29672830/next-generation-lineage-discovery-a-case-study-of-tuberous-claytonia-l
#7
Thomas R Stoughton, Ricardo Kriebel, Diana D Jolles, Robin L O'Quinn
PREMISE OF THE STUDY: Species formation is an intuitive endpoint of reproductive isolation, but circumscribing taxa that arise during speciation can be difficult because of gene flow, morphological continuity, hybridization or polyploidization, and low sequence variation among newly diverged lineages. Nonetheless, species complexes are ubiquitous, and their classification is essential for understanding how diversity influences ecosystem function. METHODS: We used modern sequencing technology to identify lineages of perennial Claytonia L...
April 19, 2018: American Journal of Botany
https://www.readbyqxmd.com/read/29669900/genome-wide-single-nucleotide-polymorphism-scan-suggests-adaptation-to-urbanization-in-an-important-pollinator-the-red-tailed-bumblebee-bombus-lapidarius-l
#8
Panagiotis Theodorou, Rita Radzevičiūtė, Belinda Kahnt, Antonella Soro, Ivo Grosse, Robert J Paxton
Urbanization is considered a global threat to biodiversity; the growth of cities results in an increase in impervious surfaces, soil and air pollution, fragmentation of natural vegetation and invasion of non-native species, along with numerous environmental changes, including the heat island phenomenon. The combination of these effects constitutes a challenge for both the survival and persistence of many native species, while also imposing altered selective regimes. Here, using 110 314 single nucleotide polymorphisms generated by restriction-site-associated DNA sequencing, we investigated the genome-wide effects of urbanization on putative neutral and adaptive genomic diversity in a major insect pollinator, Bombus lapidarius , collected from nine German cities and nine paired rural sites...
April 25, 2018: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29668942/patient-reported-experiences-of-patient-safety-incidents-need-to-be-utilized-more-systematically-in-promoting-safe-care
#9
Merja Sahlström, Pirjo Partanen, Hannele Turunen
Objective: To analyze patient safety incidents (PSIs) reported by patients and their use in Finnish healthcare organizations. Study Design: Cross-sectional study. Setting: About 15 Finnish healthcare organizations ranging from specialized hospital care to home care, outpatient and inpatient clinics, and geographically diverse areas of Finland. Participants: The study population included all Finnish patients who had voluntarily reported PSI via web-based system in 2009-15...
April 16, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29668016/genetic-and-ecological-niche-modeling-of-calydorea-crocoides-iridaceae-an-endemic-species-of-subtropical-highland-grasslands
#10
Juliana Lustosa Matos de Alencar, Eliane Kaltchuk-Santos, Juliana Fachinetto, Luana Olinda Tacuatiá, Eliana Regina Forni-Martins, Eudes Maria Stiehl-Alves, Tatiana Teixeira de Souza-Chies
Evolutionary analyses have been widely used for evaluation of genetic diversity of natural populations and correlate these data to the fitness of the species, especially in the case of threatened species. Calydorea crocoides occurs in a restricted area at altitudes from 800 to 1500 m in southern Brazil and is considered endangered. A study assessing genetic diversity, cytogenetic features and ecological niche was performed aiming to characterize C. crocoides by multidisciplinary approaches. Molecular data highlighted that most of the total variation (76%; p < 0...
2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29667067/a-first-in-class-inhibitor-mln4924-pevonedistat-induces-cell-cycle-arrest-senescence-and-apoptosis-in-human-renal-cell-carcinoma-by-suppressing-ube2m-dependent-neddylation-modification
#11
Bo Xu, Yuyou Deng, Ran Bi, Haoran Guo, Chang Shu, Neelam Kumari Shah, Junliang Chang, Guanchen Liu, Yujun Du, Wei Wei, Chunxi Wang
PURPOSE: MLN4924 is a second-generation inhibitor that targets ubiquitin-proteasome system by inhibiting neddylation activation enzyme (NAE), and subsequently blocking the neddylation-dependent activation of Cullin-RING E3 ligases (CRLs), which leads to the accumulation of CRLs substrates and hence, suppressing diverse tumor development. In this study, we investigated the potential application of this first-in-class inhibitor MLN4924 in the treatment of human renal cell carcinoma both in vitro and in vivo...
April 17, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29666882/river-flow-impacts-bacterial-and-archaeal-community-structure-in-surface-sediments-in-the-northern-gulf-of-mexico
#12
Alice C Ortmann, Pamela M Brannock, Lei Wang, Kenneth M Halanych
Meiobenthic community structure in the northern Gulf of Mexico has been shown to be driven by geographical differences due to inshore-offshore gradients and location relative to river discharge. Samples collected along three transects spanning Mobile Bay, Alabama, showed significant differences in meiobenthic communities east of the bay compared to those sampled from the west. In contrast, analysis of bacterial and archaeal communities from the same sediment samples shows that the inshore-offshore gradient has minimal impact on their community structure...
April 17, 2018: Microbial Ecology
https://www.readbyqxmd.com/read/29665147/detrimental-effects-of-a-novel-flow-regime-on-the-functional-trajectory-of-an-aquatic-invertebrate-metacommunity
#13
Albert Ruhi, Xiaoli Dong, Courtney H McDaniel, Darold P Batzer, John L Sabo
Novel flow regimes resulting from dam operations and overallocation of freshwater resources are an emerging consequence of global change. Yet, anticipating how freshwater biodiversity will respond to surging flow regime alteration requires overcoming two challenges in environmental flow science: shifting from local to riverscape-level understanding of biodiversity dynamics, and from static to time-varying characterizations of the flow regime. Here, we used time-series methods (wavelets and multivariate autoregressive models) to quantify flow-regime alteration and to link time-varying flow regimes to the dynamics of multiple local communities potentially connected by dispersal (i...
April 17, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29664968/water-system-is-a-controlling-variable-modulating-bacterial-diversity-of-gastrointestinal-tract-and-performance-in-rainbow-trout
#14
Omolola C Betiku, Carl J Yeoman, T Gibson Gaylord, Benjamin Americus, Sarah Olivo, Glenn C Duff, Wendy M Sealey
A two-phase feeding study evaluating performance of rainbow trout and comparing luminal and mucosal gastrointestinal tract (GIT) bacterial community compositions when fed two alternative protein diets in two rearing systems was conducted. Alternative protein diets (animal protein and plant protein diets) balanced with crystalline amino acids: lysine, methionine and threonine or unbalanced, were fed to rainbow trout in two separate water systems (recirculating (RR) and flow-through (FF)) for a period of 16 weeks...
2018: PloS One
https://www.readbyqxmd.com/read/29662501/species-boundaries-between-three-sympatric-oak-species-quercus-aliena-q-dentata-and-q-variabilis-at-the-northern-edge-of-their-distribution-in-china
#15
Jia Lyu, Jia Song, Yuan Liu, Yuyao Wang, Junqing Li, Fang K Du
Oaks are important timber trees with wide distributions in China, but few genetic studies have been conducted on a fine scale. In this study, we seek to investigate the genetic diversity and differentiation of three sympatric oak species ( Quercus aliena Blume, Quercus dentata Thunb. ex Murray, and Quercus variabilis Blume) in their northern distribution in China using 17 bi-parentally inherited nSSRs markers and five maternally inherited chloroplast DNA (cpDNA) fragments. Both the cpDNA and the nSSRs show a high level of genetic differentiation between different oak sections...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29662500/genetic-resources-in-the-calabaza-pipiana-squash-cucurbita-argyrosperma-in-mexico-genetic-diversity-genetic-differentiation-and-distribution-models
#16
Guillermo Sánchez-de la Vega, Gabriela Castellanos-Morales, Niza Gámez, Helena S Hernández-Rosales, Alejandra Vázquez-Lobo, Erika Aguirre-Planter, Juan P Jaramillo-Correa, Salvador Montes-Hernández, Rafael Lira-Saade, Luis E Eguiarte
Analyses of genetic variation allow understanding the origin, diversification and genetic resources of cultivated plants. Domesticated taxa and their wild relatives are ideal systems for studying genetic processes of plant domestication and their joint is important to evaluate the distribution of their genetic resources. Such is the case of the domesticated subspecies C. argyrosperma ssp. argyrosperma , known in Mexico as calabaza pipiana , and its wild relative C. argyrosperma ssp. sororia . The main aim of this study was to use molecular data (microsatellites) to assess the levels of genetic variation and genetic differentiation within and among populations of domesticated argyrosperma across its distribution in Mexico in comparison to its wild relative, sororia , and to identify environmental suitability in previously proposed centers of domestication...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29662344/manipulating-nanoparticle-transport-within-blood-flow-through-external-forces-an-exemplar-of-mechanics-in-nanomedicine
#17
REVIEW
Huilin Ye, Zhiqiang Shen, Le Yu, Mei Wei, Ying Li
A large number of nanoparticles (NPs) have been raised for diverse biomedical applications and some of them have shown great potential in treatment and imaging of diseases. Design of NPs is essential for delivery efficacy due to a number of biophysical barriers, which prevents the circulation of NPs in vascular flow and their accumulation at tumour sites. The physiochemical properties of NPs, so-called '4S' parameters, such as size, shape, stiffness and surface functionalization, play crucial roles in their life journey to be delivered to tumour sites...
March 2018: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29661226/spatio-temporal-genetic-structure-of-anopheles-gambiae-in-the-northwestern-lake-victoria-basin-uganda-implications-for-genetic-control-trials-in-malaria-endemic-regions
#18
Martin Lukindu, Christina M Bergey, Rachel M Wiltshire, Scott T Small, Brian P Bourke, Jonathan K Kayondo, Nora J Besansky
BACKGROUND: Understanding population genetic structure in the malaria vector Anopheles gambiae (s.s.) is crucial to inform genetic control and manage insecticide resistance. Unfortunately, species characteristics such as high nucleotide diversity, large effective population size, recent range expansion, and high dispersal ability complicate the inference of genetic structure across its range in sub-Saharan Africa. The ocean, along with the Great Rift Valley, is one of the few recognized barriers to gene flow in this species, but the effect of inland lakes, which could be useful sites for initial testing of genetic control strategies, is relatively understudied...
April 16, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29660619/highly-efficient-removal-of-nitrogen-and-phosphorus-in-an-electrolysis-integrated-horizontal-subsurface-flow-constructed-wetland-amended-with-biochar
#19
Yan Gao, Wen Zhang, Bin Gao, Wen Jia, Aijun Miao, Lin Xiao, Liuyan Yang
Electrolysis combined with biochar (BC) was used in a constructed wetland to intensify nitrogen (N) and phosphorus (P) removal from wastewater simultaneously. A pilot study was conducted using an electrolysis-integrated, BC-amended, horizontal, subsurface-flow, constructed wetland (E-BHFCW). The research results showed that both electrolysis and BC substrate played important roles in the intensified, constructed wetland. The electrolysis combined BC substrate greatly enhanced the removal rates of nitrate (49...
April 4, 2018: Water Research
https://www.readbyqxmd.com/read/29660038/external-ventricular-drain-and-hemorrhage-in-aneurysmal-subarachnoid-hemorrhage-patients-on-dual-antiplatelet-therapy-a-retrospective-cohort-study
#20
Joseph S Hudson, Benjamin S Prout, Yasunori Nagahama, Daichi Nakagawa, Waldo R Guerrero, Mario Zanaty, Nohra Chalouhi, Pascal Jabbour, Sudeepta Dandapat, Lauren Allan, Santiago Ortega-Gutierrez, Edgar A Samaniego, David Hasan
BACKGROUND: Stenting and flow diversion for aneurysmal sub arachnoid hemorrhage (aSAH) require the use of dual antiplatelet therapy (DAPT). OBJECTIVE: To investigate whether DAPT is associated with hemorrhagic complication following placement of external ventricular drains (EVD) in patients with aSAH. METHODS: Rates of radiographically identified hemorrhage associated with EVD placement were compared between patients who received DAPT for stenting or flow diversion, and patients who underwent microsurgical clipping or coiling and did not receive DAPT by way of a backward stepwise multivariate analysis...
April 11, 2018: Neurosurgery
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