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Arterial venous malformation

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https://www.readbyqxmd.com/read/28637821/endovascular-management-of-aneurysms-associated-with-spinal-arteriovenous-malformations
#1
Sung Chul Jung, Yunsun Song, Su Hee Cho, Joonggoo Kim, Seung Yeon Noh, Sang Hun Lee, Jae Jon Sheen, Seung Chul Rhim, Sang Ryong Jeon, Dae Chul Suh
BACKGROUND: Spinal aneurysms are rare among spinal arteriovenous malformations (SAVMs). There are few reports of endovascular management of spinal aneurysms associated with SAVM. OBJECTIVE: To present endovascular management of aneurysms associated with SAVM. METHODS: Of 91 patients with SAVMs,eight (9%) presented with aneurysms. Of these, three were male and five were female with a median age of 18 years (range 11-38). We evaluated the presenting pattern, lesion level, type of the target aneurysm related to the presenting pattern and AVM nidus, and the result obtained after embolization or open surgery...
June 21, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28599054/coexistence-of-ephb1-and-ephrinb2-in-port-wine-stain-endothelial-progenitor-cells-contributes-to-clinicopathological-vasculature-dilatation
#2
W Tan, J Wang, F Zhou, L Gao, Y Rong, H Liu, A Sukanthanag, G Wang, M C Mihm, D-B Chen, J S Nelson
Port wine stain (PWS) is a vascular malformation characterized by a progressive dilatation of post-capillary venules, but the molecular pathogenesis remains obscure. We hypothesized that PWS endothelial cells (ECs) present a unique molecular phenotype that lead to pathoanatomic PWS vasculatures. We herein show multiple clinicopathologic features of PWS blood vessels during the development and progression of the disease. 1) There were no normal arterioles and venules phenotypically and morphologically observed in PWS skin; both arterioles and venules showed differentiation impairments, resulting in a reduction of arteriole-like vasculatures and defects in capillary loop formation in PWS lesions...
June 9, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28559076/prenatal-diagnosis-and-multimodal-neonatal-treatment-of-a-rare-pial-arteriovenous-fistula-case-report-and-review-of-the-literature
#3
Alessandro Pedicelli, Marta Iacobucci, Paolo Frassanito, Emilio Lozupone, Concezio Di Rocco, Cesare Colosimo
Intracranial pial arteriovenous fistulas (PAVFs) are direct communications between the arterial and venous system of the brain, with the characteristic absence of a plexiform nidus, as seen in the classic cerebral arteriovenous malformations. These vascular malformations, usually occurring in the pediatric population, are very rarely diagnosed in uterus, due to a lack of understanding of the condition and because they may be hard to visualize. We report a rare case of a mass effect PAVF diagnosed with fetal MRI, involving the right cerebral hemisphere, fed by a pericallosal artery and associated with a giant venous dilatation...
May 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28552158/epidemiology-genetics-pathophysiology-and-prognostic-classifications-of-cerebral-arteriovenous-malformations
#4
Alp Ozpinar, Gustavo Mendez, Adib A Abla
Arteriovenous malformations (AVMs) are vascular deformities involving fistula formation of arterial to venous structures without an intervening capillary bed. Such anomalies can prove fatal as the high arterial flow can disrupt the integrity of venous walls, thus leading to dangerous sequelae such as hemorrhage. Diagnosis of these lesions in the central nervous system can often prove challenging as intracranial AVMs represent a heterogeneous vascular pathology with various presentations and symptomatology. The literature suggests that most brain AVMs (bAVMs) are identified following evaluation of the etiology of acute cerebral hemorrhage, or incidentally on imaging associated with seizure or headache workup...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28552148/arteriovenous-malformations-epidemiology-clinical-presentation-and-diagnostic-evaluation
#5
Joshua W Osbun, Matthew R Reynolds, Daniel L Barrow
Brain arteriovenous malformations (AVMs) represent an uncommon disease of the central nervous system characterized by an arteriovenous shunt in which one or multiple arterial pedicles feed into a vascular nidus, creating early drainage into a venous outflow channel. These lesions are considered to be congenital and can come to clinical attention in a variety of ways such as seizure, intracranial hemorrhage, chronic headache or progressive neurological deficit. We focus on the epidemiology, clinical presentation and diagnostic evaluation in this chapter...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28552141/spinal-arteriovenous-fistulae-surgical-management
#6
Arthur L Day, Ali Hassoun Turkmani, P Roc Chen
Spinal vascular malformations include several types of pathologic entities with multiple variations in their neurologic presentation and risks. Spinal dural arteriovenous fistulae (SDAVF) are the most frequent type, and account for 70% of all lesions affecting the spinal cord. The nonspecific early neurologic symptoms of SDAVF often make early diagnosis of this clinical entity challenging, and a delay in diagnosis or appropriate treatment often has devastating consequences on spinal cord function. The lesion can invariably be obliterated with surgical occlusion of the intradural arterialized venous reflux, and progression of neurologic deficits is usually arrested and sometimes reversed...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28552137/the-natural-history-of-cerebral-arteriovenous-malformations
#7
Anil Can, Bradley A Gross, Rose Du
Cerebral arteriovenous malformations (AVMs) are composed of a complex tangle of abnormal arteries and veins and are a significant source of cerebral hemorrhage and consequent morbidity and mortality in young adults, representing a diagnostic and therapeutic challenge. Current natural-history studies of cerebral AVMs report overall annual rates of 1% and 3% for the risk of epilepsy and hemorrhage, respectively. Unruptured AVMs have an annual hemorrhage rate of 2.2% while ruptured lesions have an annual hemorrhage rate of 4...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28552134/radiosurgery-for-dural-arteriovenous-malformations
#8
Conor Grady, Carolina Gesteira Benjamin, Douglas Kondziolka
Intracranial dural arteriovenous malformations (DAVFs) are relatively uncommon vascular lesions characterized by the direct connection of dural arteries into dural venous sinuses or leptomeningeal veins. Strategies for the treatment of these complex lesions have evolved significantly over the past three decades, and include open surgical disconnection, endovascular embolization, stereotactic radiosurgery (SRS), or a combination of these approaches. Radiosurgical intervention is unique in offering significant benefits to patients while exposing them to few of the risks associated with more invasive interventions...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28552133/endovascular-management-of-intracranial-dural-arteriovenous-fistulas
#9
Celene B Mulholland, M Yashar S Kalani, Felipe C Albuquerque
Dural arteriovenous fistulas are a heterogeneous group of lesions that comprise 10-15% of intracranial vascular malformations. The treatment strategy is devised after careful consideration of the arterial supply, venous drainage, clinical presentation, and risk of progression, hemorrhage, or neurologic decline. With recent advancements in endovascular technology, the majority of dural arteriovenous fistulas can be treated with either transarterial or transvenous embolization. Those that cannot be fully treated by endovascular means are approached with either adjuvant surgery or radiotherapy...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28552132/surgical-management-of-cerebral-dural-arteriovenous-fistulae
#10
Martin J Rutkowski, Brian Jian, Michael T Lawton
Dural arteriovenous fistulae are high flow, low resistance intracranial vascular malformations defined by an aberrant connection between an artery and dural vein or sinus. Symptomatology and presentation are highly dependent on location, generally categorized as supratentorial, tentorial, or infratentorial, and consist primarily of sequelae secondary to local venous hypertension, insufficiency, and cortical venous reflux. Surgery is generally reserved for high risk or persistently symptomatic lesions that are unamenable or unresponsive to endovascular therapy...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28530660/endoglin-prevents-vascular-malformation-by-regulating-flow-induced-cell-migration-and-specification-through-vegfr2-signalling
#11
Yi Jin, Lars Muhl, Mikhail Burmakin, Yixin Wang, Anne-Claire Duchez, Christer Betsholtz, Helen M Arthur, Lars Jakobsson
Loss-of-function (LOF) mutations in the endothelial cell (EC)-enriched gene endoglin (ENG) cause the human disease hereditary haemorrhagic telangiectasia-1, characterized by vascular malformations promoted by vascular endothelial growth factor A (VEGFA). How ENG deficiency alters EC behaviour to trigger these anomalies is not understood. Mosaic ENG deletion in the postnatal mouse rendered Eng LOF ECs insensitive to flow-mediated venous to arterial migration. Eng LOF ECs retained within arterioles acquired venous characteristics and secondary ENG-independent proliferation resulting in arteriovenous malformation (AVM)...
June 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28524790/cognard-type-v-intracranial-dural-arteriovenous-fistula-presenting-in-a-pediatric-patient-with-rapid-progressive-myelopathy
#12
Walter J Jermakowicz, Alexander G Weil, Artyom Vlasenko, Sanjiv Bhatia, Toba N Niazi
Cognard Type V dural arteriovenous fistulas (dAVFs) are a unique type of cranial vascular malformation characterized by congestion of the perimedullary venous system that may lead to devastating spinal cord pathology if left untreated. The authors present the first known case of a pediatric patient diagnosed with a Type V dAVF. A 14-year-old girl presented with a 3-week history of slowly progressive unilateral leg weakness that quickly progressed to bilateral leg paralysis, sphincter dysfunction, and complete sensory loss the day of her presentation...
May 19, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28491192/a-case-report-of-spinal-dural-arteriovenous-fistula-origins-determinants-and-consequences-of-abnormal-vascular-malformations
#13
Sherry M Zakhary, Christopher L Hoehmann, Joshua A Cuoco, Kyle Hitscherich, Hamid Alam, German Torres
A spinal dural arteriovenous fistula is an abnormally layered connection between radicular arteries and venous plexus of the spinal cord. This vascular condition is relatively rare with an incidence of 5-10 cases per million in the general population. Diagnosis of spinal dural arteriovenous fistula is differentiated by contrast-enhanced magnetic resonance angiography or structural magnetic resonance imaging, but a definitive diagnosis requires spinal angiography methods. Here, we report a case of a 67-year-old female with a spinal dural arteriovenous fistula, provide a pertinent clinical history to the case nosology, and discuss the biology of adhesive proteins, chemotactic molecules, and transcription factors that modify the behavior of the vasculature to possibly cause sensorimotor deficits...
June 2017: Radiology case reports
https://www.readbyqxmd.com/read/28457930/delayed-venous-drainage-in-ruptured-arteriovenous-malformations-based-on-quantitative-color-coded-digital-subtraction-angiography
#14
Jan-Karl Burkhardt, Xiaolin Chen, Ethan A Winkler, Daniel L Cooke, Helen Kim, Michael T Lawton
OBJECTIVE: Clinically applicable hemodynamic risk factors to predict arteriovenous malformation (AVM) rupture are missing in the literature. The aim of this study was to identify hemodynamic parameters in ruptured and unruptured AVMs based on catheter angiography. METHODS: Patients with frontal and temporal AVMs and Siemens syngo iFlow color-coding angiography were included in this study (n=71). Clinical and radiological data (age, gender, Spetzler-Martin (SM) and supplemented SM grade, and rupture status), and hemodynamic features (contrast mean transit time (MTT) of feeding arteries, draining veins, AVM nidus, and the cerebral circulation time (CCT)) were analyzed...
April 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28440519/-prevention-diagnosis-and-treatment-of-perioperative-complications-of-bariatric-and-metabolic-surgery
#15
Haifu Wu, Ming Zhong, Di Zhou, Chenye Shi, Heng Jiao, Wei Wu, Xinxia Chang, Jing Cang, Hua Bian
Surgical operation in treating obesity and type 2 diabetes is popularizing rapidly in China. Correct prevention and recognition of perioperation-related operative complications is the premise of ensuring surgical safety. Familiar complications of the operation include deep venous thrombosis, pulmonary artery embolism, anastomotic bleeding, anastomotic fistula and marginal ulcer. The prevention of deep venous thrombosis is better than treatment. The concrete measures contain physical prophylaxis (graduated compression stocking and intermittent pneumatic compression leg sleeves) and drug prophylaxis (unfractionated heparin and low molecular heparin), and the treatment is mainly thrombolysis or operative thrombectomy...
April 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28422344/use-of-blood-pool-agents-with-steady-state-mri-to-assess-the-vascular-system
#16
Avnesh S Thakor, John Chung, Premal Patel, Anthony Chan, Amdad Ahmed, Graeme McNeil, David M Liu, Bruce Forster, Darren Klass
Over the past two decades there have been significant advances in the use of magnetic resonance imaging (MRI) to assess the vascular system. New imaging sequences and improvements in magnet design have enabled the creation of higher spatial resolution images. MRI is now a viable alternative imaging modality when compared to both invasive angiography and computed tomographic angiography. The use of blood pool agents has further facilitated the use of MR angiography (MRA); their high molecular weight allows for lower doses of contrast medium administration while their prolonged presence in the blood stream allows for repeated high-quality volumetric imaging of both the arterial and venous circulation...
April 19, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28411709/chronic-refractory-venous-ulcer-exacerbated-by-a-congenital-pelvic-arteriovenous-malformation-successfully-treated-by-transarterial-onyx-embolization
#17
Naiem Nassiri, Dustin T Crystal, Catherine Hoyt, Randy Shafritz
Congenital arteriovenous malformations (AVMs) are an important but often neglected cause of lower extremity venous hypertension. A case of a chronic refractory venous stasis ulcer of the lower extremity exacerbated by a pelvic AVM is presented. Healing of the ulcer was achieved at 2 months without recurrence at 1 year after superselective ethylene vinyl alcohol copolymer (Onyx 34; ev3, Covidien, Plymouth, Minn) embolization of the AVM nidus. Chronic venous arterialization should be considered in cases of refractory, nonhealing venous ulcers...
May 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28410939/acute-hand-ischemia-following-elective-venous-sclerotherapy-for-dorsal-hand-varicose-veins
#18
Steven M Andelman, Amanda L Walsh, Todd A Rubin, Michael R Hausman
Venous sclerotherapy is an emerging cosmetic treatment option for dorsal hand varicose veins. Although venous sclerotherapy is considered a safe and effective procedure for treatment of venous malformations and varicosities in both the upper and lower extremities, inadvertent injection of the sclerosing agent into the arterial system has led to reported instances of acute ischemic events and distal limb necrosis. This is a rare but well-documented complication of lower-extremity venous sclerotherapy. Only 2 cases have been reported in upper-extremity venous sclerotherapy, both of which occurred during treatment of complex vascular malformations...
April 12, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28402473/cavernous-malformation-associated-with-arterialized-developmental-venous-anomaly-a-case-report
#19
Kenta Nakase, Yasushi Motoyama, Tokiko Nakai, Yasuhiro Takeshima, Ichiro Nakagawa, Young-Su Park, Chiho Ohbayashi, Hiroyuki Nakase
BACKGROUND AND IMPORTANCE: Formation of cavernous malformations (CMs) has been recognized to be associated with developmental venous anomaly (DVA) by many authors. Hemodynamic stress due to venous outflow restriction could be hypothesized as a cause. On the other hand, a rare subgroup of DVA with an arterial component has been reported as likely to hemorrhage or be symptomatic. Cases of arterialized DVAs reported previously have not been associated with the presence of CM. CLINICAL PRESENTATION: We present herein a case report of arterialized DVA in the brainstem with repeated cerebellar hemorrhage...
June 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28396981/multiple-variations-of-the-cerebral-arteries-associated-with-tetralogy-of-fallot-a-case-report
#20
Akira Uchino, Naoko Saito, Eito Kozawa, Satoshi Masutani
Tetralogy of Fallot (TOF) can be associated with vascular malformations or variations, especially of the aortic arch or supracardiac major venous systems. We report its association with an extremely rare combination of three such variations of the cerebral arteries-a right persistent hypoglossal artery, an extremely rare left carotid-right anterior cerebral artery (ACA) anastomosis, and a left accessory middle cerebral artery arising from the A1-A2 junction of the left ACA-which were diagnosed by magnetic resonance angiography in a 9-year-old girl during evaluation of multiple acute cerebral infarctions...
April 10, 2017: Surgical and Radiologic Anatomy: SRA
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