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https://www.readbyqxmd.com/read/29451367/the-association-between-famine-exposure-in-early-life-and-type-2-diabetes-and-hyperglycemia-in-adulthood-results-from-the-china-health-and-retirement-longitudinal-study-charls
#1
Yanxin Sun, Longfei Zhang, Wenhou Duan, Xin Meng, Chongqi Jia
BACKGROUND: Some studies have shown that famine in early life may influence T2D. The majority of studies on this topic have revealed an association between famine exposure in early life and T2D in adulthood. However, several studies on the Great Chinese Famine were not conducted nationwide. Because the severity of the Great Chinese Famine varied in different regions, the results of regional studies were usually limited. METHODS: We included 7262 participants who were born between October 1, 1949, and July 1, 1966 who were participants in baseline data collection for CHARLS in 2011...
February 16, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29408921/the-relationship-between-famine-exposure-during-early-life-and-body-mass-index-in-adulthood-a-systematic-review-and-meta-analysis
#2
Jielin Zhou, Liangjian Zhang, Peng Xuan, Yong Fan, Linsheng Yang, Chunqiu Hu, Qingli Bo, Guoxiu Wang, Jie Sheng, Sufang Wang
BACKGROUND: Previous epidemiologic studies have reported famine exposure during early life association with overweight or obesity in adulthood, but a consistent perspective has not been established to date. PURPOSE: To determine, by conducting a systematic review and meta-analysis, whether exposure to famine could increase body mass index (BMI) in adult or not, and assess the association between famine exposure and the risk of overweight or obesity. METHODS: Published articles were systematically searched (until August, 2017) from PubMed, ScienceDirect, Cochrane, and China National Knowledge Infrastructure...
2018: PloS One
https://www.readbyqxmd.com/read/29400076/exposure-to-the-chinese-famine-in-early-life-and-depression-in-adulthood
#3
Yaru Li, Liyun Zhao, Dongmei Yu, Gangqiang Ding
We aimed to investigate whether exposure to the Chinese famine (1959-1961) in early life was associated with depression in adulthood. We included 17,505 participants from the China health and retirement longitudinal study (CHARLS). Participants were classified into indirect and direct exposure groups. And the directly exposure groups including prenatal, childhood, adolescence/adult exposure groups. Depression was diagnosed by Center for Epidemiological Studies Depression Scale-10 (CES-D) score. Multivariate logistic regression model was used to calculate the odd ratios (ORs) and 95% confidence intervals (CIs) of depression...
February 4, 2018: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/29399631/dna-methylation-as-a-mediator-of-the-association-between-prenatal-adversity-and-risk-factors-for-metabolic-disease-in-adulthood
#4
Elmar W Tobi, Roderick C Slieker, René Luijk, Koen F Dekkers, Aryeh D Stein, Kate M Xu, P Eline Slagboom, Erik W van Zwet, L H Lumey, Bastiaan T Heijmans
Although it is assumed that epigenetic mechanisms, such as changes in DNA methylation (DNAm), underlie the relationship between adverse intrauterine conditions and adult metabolic health, evidence from human studies remains scarce. Therefore, we evaluated whether DNAm in whole blood mediated the association between prenatal famine exposure and metabolic health in 422 individuals exposed to famine in utero and 463 (sibling) controls. We implemented a two-step analysis, namely, a genome-wide exploration across 342,596 cytosine-phosphate-guanine dinucleotides (CpGs) for potential mediators of the association between prenatal famine exposure and adult body mass index (BMI), serum triglycerides (TG), or glucose concentrations, which was followed by formal mediation analysis...
January 2018: Science Advances
https://www.readbyqxmd.com/read/29335447/exposure-to-famine-in-early-life-and-chronic-kidney-diseases-in-adulthood
#5
Ningjian Wang, Zhiyuan Ning, Fangzhen Xia, Chi Chen, Jing Cheng, Yi Chen, Yingli Lu
OBJECTIVE: Chronic kidney disease (CKD) is an increasing contributor to the global disease burden. Previous findings indicated that exposure to famine in early life was associated with various metabolic diseases and urinary protein levels. We aimed to assess whether the exposure to China's Great Famine 1959-1962 during fetal or childhood period was associated with glomerular filtration rate (GFR) and risk of CKD (eGFR<60 mL/min per 1.73 m2) in adulthood. MATERIALS AND METHODS: SPECT-China was a population-based observational study in 2014-2015...
January 15, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29333753/comparative-performance-of-different-scale-down-simulators-of-substrate-gradients-in-penicillium-chrysogenum-cultures-the-need-of-a-biological-systems-response-analysis
#6
Guan Wang, Junfei Zhao, Cees Haringa, Wenjun Tang, Jianye Xia, Ju Chu, Yingping Zhuang, Siliang Zhang, Amit T Deshmukh, Walter van Gulik, Joseph J Heijnen, Henk J Noorman
In a 54 m3 large-scale penicillin fermentor, the cells experience substrate gradient cycles at the timescales of global mixing time about 20-40 s. Here, we used an intermittent feeding regime (IFR) and a two-compartment reactor (TCR) to mimic these substrate gradients at laboratory-scale continuous cultures. The IFR was applied to simulate substrate dynamics experienced by the cells at full scale at timescales of tens of seconds to minutes (30 s, 3 min and 6 min), while the TCR was designed to simulate substrate gradients at an applied mean residence time (τc) of 6 min...
January 15, 2018: Microbial Biotechnology
https://www.readbyqxmd.com/read/29299735/exposure-to-chinese-famine-in-early-life-and-the-risk-of-dyslipidemia-in-adulthood
#7
Xueling Xin, Weijing Wang, Hui Xu, Zongyao Li, Dongfeng Zhang
PURPOSE: Early life exposure to famine may affect the susceptibility to metabolic disorders including dyslipidemia. However, few studies explored the association between them in Chinese population. We aimed to evaluate the association between Chinese famine (1959-1961) exposure during early life and the risk of dyslipidemia in adulthood. METHODS: The study performed a historic cohort study and data were from China Health and Nutrition Survey conducted in 2009. A total of 4843 subjects born between 1941 and 1966 were categorized into fetal-infant exposed group (N = 433), childhood exposed group (N = 2132), adolescence exposed group (N = 1140), and unexposed group (N = 1138), respectively...
January 3, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29221761/enrichment-of-pha-producing-bacteria-under-continuous-substrate-supply
#8
Leonie Marang, Mark C M van Loosdrecht, Robbert Kleerebezem
To enrich polyhydroxyalkanoate (PHA) producing microbial communities, generally, a feast-famine regime is applied. Here we investigated the impact of continuous substrate feeding on the enrichment of PHA-producing bacteria in two sequencing batch reactors (SBRs). In the first reactor, the substrate (acetate) was dosed continuously and Zoogloea sp. was enriched. The culture accumulated PHA upon exposure to excess carbon, but the PHA production rate and storage capacity (53wt.%) were one-fifth of that observed for enrichment cultures in a standard, pulse-fed SBR dominated by the PHA producer Plasticicumulans acidivorans...
December 5, 2017: New Biotechnology
https://www.readbyqxmd.com/read/29207944/incidence-of-breast-cancer-in-chinese-women-exposed-to-the-1959-1961-great-chinese-famine
#9
Dandan He, Yuan Fang, Marc J Gunter, Dongli Xu, Yanping Zhao, Jie Zhou, Hong Fang, Wang Hong Xu
BACKGROUND: The association of malnutrition in early life with breast cancer risk has been studied in Europe by investigating survivors of the Dutch Hunger Winter Famine, but not in China. We evaluated the effect of exposure to the 1959-1961 Great Leap Forward famine on subsequent breast cancer risk in Chinese women. METHODS: A total of 59,060 women born in 1955~1966 were recruited from Minhang district, Shanghai, China, during the period 2008 to 2012. A baseline survey was conducted to collect demographic characteristics and known risk factors for breast cancer...
December 5, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29198238/the-effect-of-adverse-intrauterine-conditions-early-childhood-growth-and-famine-exposure-on-age-at-menopause-a-systematic-review
#10
S Sadrzadeh, M Verschuuren, L J Schoonmade, C B Lambalk, R C Painter
When the follicle reserve, which is developed solely during the fetal period, is depleted, women enter menopause. Intrauterine and childhood adverse conditions might affect the ovarian capacity by influencing follicle production in the first trimester, limiting the initial follicle pool or mediate an accelerated follicular loss thereafter. To investigate if adverse early life influences result in younger age at menopause, the following online databases were systematically searched: PubMed, EMBASE, CINHAL (EBSCO) and Cochrane library (Wiley) up to 1 January 2017...
December 4, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29165159/increase-in-the-prevalence-of-hypertension-among-adults-exposed-to-the-great-chinese-famine-during-early-life
#11
Lingli Liu, Xianglong Xu, Huan Zeng, Yong Zhang, Zumin Shi, Fan Zhang, Xianqing Cao, Yao Jie Xie, Cesar Reis, Yong Zhao
OBJECTIVE: This study aimed to assess the association between exposure to the Great Chinese Famine (1959-1961) during early life and hypertension in adulthood. METHODS: From July to September 2009, 1224 eligible adults were recruited in a cross-sectional survey using a multi-stage stratified random sampling method in Chongqing China. A questionnaire was used to collect information of hypertension and sociodemographic factors. Participants were categorized as childhood, fetal, and none exposure to famine based on the date of birth...
August 25, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29161448/prenatal-famine-exposure-adulthood-obesity-patterns-and-risk-of-type-2-diabetes
#12
Ruogu Meng, Jun Lv, Canqing Yu, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Hui Zhang, Xiaofang Chen, Junshi Chen, Zhengming Chen, Lu Qi, Liming Li
Background: Prenatal exposure to famine and adulthood obesity have been independently related to the risk of type 2 diabetes; however, little is known about the joint effects of these risk factors at different stages of life on adulthood diabetes risk. Methods: The analysis included 88 830 participants of the China Kadoorie Biobank, who were born around the time of the Chinese Great Famine and without diabetes, cardiovascular diseases, or cancer at baseline. We defined famine exposure subgroups as nonexposed (born between 1 October 1962 and 30 September 964), fetal-exposed (born between 1 October 1959 and 30 September 1961) and early-childhood exposed (born between 1 October 1956 and 30 September 1958)...
November 17, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29126190/early-life-exposure-to-china-s-1959-61-famine-and-midlife-cognition
#13
Hongwei Xu, Zhenmei Zhang, Lydia Li, Jinyu Liu
Background: Existing studies of the 1944-45 Dutch famine found little evidence of the association between early life malnutrition and midlife cognition. Methods: Among 2446 rural participants born between 1958 and 1963 in the China Health and Retirement Longitudinal Study, we examined effects of exposure to China's 1959-61 Great Leap Forward famine during prenatal and early postnatal life, on four cognitive measures in 2011 (baseline) and changes in cognition between 2011 and 2013 (first follow-up)...
November 7, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29125320/prenatal-famine-exposure-and-mental-health-in-later-midlife
#14
Thijs van den Broek, Maria Fleischmann
OBJECTIVES: Maternal malnutrition during pregnancy may have long-lasting effects on offspring's mental health. We investigate the effect of prenatal exposure to the Dutch famine (mid November 1944 to late April 1945) on mental health in later mid-life. METHODS: Data are from the Netherlands Kinship Panel Study (n = 642). We use difference-in-difference analyses to compare mental health in later midlife (measured with the MHI-5 index) across three cohorts ('pre-famine cohort', 'famine cohort', 'post-famine cohort') and across two regions (famine affected cities vs...
November 10, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/29101088/effect-of-methylene-blue-induced-photodynamic-therapy-on-a-streptococcus-mutans-biofilm-model
#15
Mariana Alencar Nemezio, Sofia Sampaio de Souza Farias, Maria Cristina Borsatto, Carolina Patrícia Aires, Silmara Aparecida Milori Corona
BACKGROUND: Several studies have reported the use of antimicrobial photodynamic therapy (aPDT) to control biofilm but its efficacy depends on several factors, such as biofilm model used. This study aims to examine whether exposure to diode laser combined with methylene blue affects the bacterial viability and polysaccharide content in a Streptococcus mutans cariogenic biofilm model, which simulated 'feast-famine' episodes of exposure to sucrose that occur in the oral cavity. MATERIALS AND METHODS: S...
October 31, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29074280/premature-brain-aging-in-humans-exposed-to-maternal-nutrient-restriction-during-early-gestation
#16
Katja Franke, Christian Gaser, Susanne R de Rooij, Matthias Schwab, Tessa J Roseboom
BACKGROUND: Prenatal exposure to undernutrition is widespread in both developing and industrialized countries, causing irreversible damage to the developing brain, resulting in altered brain structure and decreased cognitive function during adulthood. The Dutch famine in 1944/45 was a humanitarian disaster, now enabling studies of the effects of prenatal undernutrition during gestation on brain aging in late adulthood. METHODS: We hypothesized that study participants prenatally exposed to maternal nutrient restriction (MNR) would demonstrate altered brain structure resembling premature brain aging in late adulthood, expecting the effect being stronger in men...
October 23, 2017: NeuroImage
https://www.readbyqxmd.com/read/29074165/early-life-undernutrition-and-adult-height-the-dutch-famine-of-1944-45
#17
F R M Portrait, T F van Wingerden, D J H Deeg
Current research shows strong associations between adult height and several positive outcomes such as higher cognitive skills, better earning capacity, increased chance of marriage and better health. It is therefore relevant to investigate the determinants of adult height. There is mixed evidence on the effects of undernutrition during early life on adult height. Therefore, our study aims at assessing the impact of undernutrition during gestation and at ages younger than 15 on adult height. We used data from the Longitudinal Aging Study Amsterdam...
November 2017: Economics and Human Biology
https://www.readbyqxmd.com/read/29055916/the-great-chinese-famine-exposure-in-early-life-and-the-risk-of-nonalcoholic-fatty-liver-disease-in-adult-women
#18
Xiaoya Zheng, Wei Ren, Lilin Gong, Jian Long, Rong Luo, Yonghong Wang
INTRODUCTION AND AIM: Previous studies found famine exposure was associated with a higher risk of metabolic syndrome (MetS). In the study, we investigated the relationship between Chinese famine exposure and the risk of nonalcoholic fatty liver disease (NAFLD) in adult women. MATERIALS AND METHODS: Data were obtained from subjects via routine physical examinations in the Public Health Center of our hospital between 2011 and 2014. Women were categorized into the following three groups: control, prenatally exposed, and postnatally exposed...
October 16, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28731930/early-life-exposure-to-chinese-famine-modifies-the-association-between-hypertension-and-cardiovascular-disease
#19
Zumin Shi, Stephen J Nicholls, Anne W Taylor, Dianna J Magliano, Sarah Appleton, Paul Zimmet
OBJECTIVE: Studies have shown that famine exposure during early life may increase the risk of cardiovascular disease (CVD), hypertension, and diabetes during adulthood. We aimed to assess whether exposure to the Chinese famine (1959-1961) modifies the association between hypertension and CVD. METHODS: We investigated data of 5772 adults born between 1954 and 1964 from the China Health and Retirement Longitudinal Study. CVD was based on self-reported doctor's diagnosis of heart problems (heart attack, coronary heart disease, angina, congestive heart failure, or other heart problems) and stroke...
July 20, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28659214/the-risk-of-stroke-after-prenatal-exposure-to-famine
#20
J Horenblas, S R de Rooij, T J Roseboom
Prenatal exposure to famine is associated with an increased risk of metabolic and cardiovascular diseases in the offspring at adult age. The aim of this study was to assess whether prenatal exposure to undernutrition increases the risk of stroke. This study was performed in the Dutch famine birth cohort, which consist of 2414 members who were born between 1943 and 1947 in the Netherlands. In a subsample of 1177 individuals, interviews were conducted using standardized questionnaires to obtain information about medical history (which included specific questions regarding stroke) and lifestyle...
June 29, 2017: Journal of Developmental Origins of Health and Disease
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