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https://www.readbyqxmd.com/read/28076319/impact-of-nutrition-on-pollutant-toxicity-an-update-with-new-insights-into-epigenetic-regulation
#1
Jessie B Hoffman, Michael C Petriello, Bernhard Hennig
Exposure to environmental pollutants is a global health problem and is associated with the development of many chronic diseases, including cardiovascular disease, diabetes and metabolic syndrome. There is a growing body of evidence that nutrition can both positively and negatively modulate the toxic effects of pollutant exposure. Diets high in proinflammatory fats, such as linoleic acid, can exacerbate pollutant toxicity, whereas diets rich in bioactive and anti-inflammatory food components, including omega-3 fatty acids and polyphenols, can attenuate toxicant-associated inflammation...
January 11, 2017: Reviews on Environmental Health
https://www.readbyqxmd.com/read/28057132/-association-between-famine-exposure-during-early-life-and-bmi-in-adulthood
#2
R R Meng, J H Si, J Lyu, Y Guo, Z Bian, C Q Yu, H Y Zhou, Y L Tan, P Pei, J S Chen, Z M Chen, L M Li
Objective: To examine the influence of famine exposure during early life on BMI in adulthood. Methods: A total of 94 052 participants recruited in the baseline survey of China Kadoorie Biobank were included in this study. The participants who were born between October 1956 and September 1958, between October 1959 and September 1961 and between October 1962 and September 1964 were classified as group born before famine, group born during famine and group born after famine (control group). The regression coefficients and 95% confidence intervals (CIs) for BMI of famine exposure groups were estimated by linear regression model...
November 10, 2016: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28051192/global-warming-and-its-health-impact
#3
Antonella Rossati
Since the mid-19th century, human activities have increased greenhouse gases such as carbon dioxide, methane, and nitrous oxide in the Earth's atmosphere that resulted in increased average temperature. The effects of rising temperature include soil degradation, loss of productivity of agricultural land, desertification, loss of biodiversity, degradation of ecosystems, reduced fresh-water resources, acidification of the oceans, and the disruption and depletion of stratospheric ozone. All these have an impact on human health, causing non-communicable diseases such as injuries during natural disasters, malnutrition during famine, and increased mortality during heat waves due to complications in chronically ill patients...
January 2017: International Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27999932/association-of-famine-exposure-during-early-life-with-the-risk-of-type-2-diabetes-in-adulthood-a-meta-analysis
#4
Li Liu, Weijing Wang, Jianping Sun, Zengchang Pang
PURPOSE: The association between famine exposure (defined as lengthy and continuous deprivation of food) during early life and type 2 diabetes (T2DM) in adulthood remains controversial. A meta-analysis was performed to better clarify the relation of famine exposure to later T2DM risk. METHODS: A systematic literature search was performed in PubMed, Web of Science, Embase and China National Knowledge Infrastructure for relevant available articles. The articles were limited to those in English or Chinese from January 1990 to June 2016...
December 20, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27968880/exposure-to-the-chinese-famine-of-1959-61-in-early-life-and-current-health-conditions-a-systematic-review-and-meta-analysis
#5
Chihua Li, L H Lumey
BACKGROUND: Many middle-aged Chinese people have experienced the Great Leap Forward Famine of 1959-61, which could have profound long-term health consequences for exposed birth cohorts. We undertook a systematic review and meta-analysis to summarise reported famine effects on long-term health. METHODS: We searched PubMed, Embase, Chinese Wanfang Data, and Chinese National Knowledge Infrastructure databases up to December, 2015, for health outcomes related to the Chinese famine, with the keywords "China", "famine", "undernutrition", "Chinese famine", "Great Leap Forward", and "Great famine", and the MESH terms "starvation" or "malnutrition" combined with "China" or "Chinese"...
October 2016: Lancet
https://www.readbyqxmd.com/read/27927634/prenatal-exposure-to-famine-and-the-development-of-hyperglycemia-and-type-2-diabetes-in-adulthood-across-consecutive-generations-a-population-based-cohort-study-of-families-in-suihua-china
#6
Jie Li, Simin Liu, Songtao Li, Rennan Feng, Lixin Na, Xia Chu, Xiaoyan Wu, Yucun Niu, Zongxiang Sun, Tianshu Han, Haoyuan Deng, Xing Meng, Huan Xu, Zhe Zhang, Qiannuo Qu, Qiao Zhang, Ying Li, Changhao Sun
BACKGROUND: There has been increased recognition that prenatal or perinatal nutrition has an effect on the development of type 2 diabetes (T2D) in adulthood, although studies that have directly examined whether the effect could be transmitted to the next generation remain sparse. OBJECTIVE: We investigated the role of prenatal exposure to the Chinese famine in affecting future T2D risk in adulthood in 2 consecutive generations. DESIGN: A total of 1034 families, including 2068 parents [parental generation (F1)] and 1183 offspring [offspring generation (F2)], were recruited from the Suihua rural area that was affected by the Chinese Famine of 1959-1961...
January 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27894821/schizophrenia-in-mid-adulthood-after-prenatal-exposure-to-the-chinese-famine-of-1959-1961
#7
Cuntong Wang, Yudong Zhang
Analyzing data from a large-scale, nationally representative sample, this study examines the association between prenatal exposure to the Chinese Famine (1959-1961) and schizophrenia risk in mid-adulthood and its urban/rural-specific and gender-specific patterns. The results showed that the cohort conceived and born during the famine had a higher risk of schizophrenia in mid-adulthood than cohorts conceived and born before or after the famine. In addition, schizophrenia risk was higher for urban residents than for rural residents and higher for females than for males...
November 25, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27881521/is-famine-exposure-during-developmental-life-in-rural-bangladesh-associated-with-a-metabolic-and-epigenetic-signature-in-young-adulthood-a-historical-cohort-study
#8
S Finer, M S Iqbal, R Lowe, B W Ogunkolade, S Pervin, C Mathews, M Smart, D S Alam, G A Hitman
OBJECTIVES: Famine exposure in utero can 'programme' an individual towards type 2 diabetes and obesity in later life. We sought to identify, (1) whether Bangladeshis exposed to famine during developmental life are programmed towards diabetes and obesity, (2) whether this programming was specific to gestational or postnatal exposure windows and (3) whether epigenetic differences were associated with famine exposure. DESIGN: A historical cohort study was performed as part of a wider cross-sectional survey...
November 23, 2016: BMJ Open
https://www.readbyqxmd.com/read/27807599/exposure-to-severe-famine-in-the-prenatal-or-postnatal-period-and-the-development-of-diabetes-in-adulthood-an-observational-study
#9
Ningjian Wang, Jing Cheng, Bing Han, Qin Li, Yi Chen, Fangzhen Xia, Boren Jiang, Michael D Jensen, Yingli Lu
AIMS/HYPOTHESIS: Limited studies have compared the effect of prenatal or postnatal exposure to different severities of famine on the risk of developing diabetes. We aimed to measure the association between diabetes in adulthood and the exposure to different degrees of famine early in life (during the prenatal or postnatal period) during China's Great Famine (1959-1962). METHODS: Data from 3967 individuals were included (a total of 2115 individuals from areas severely affected by famine, 1858 from moderately affected areas, 6 excluded due to missing data)...
February 2017: Diabetologia
https://www.readbyqxmd.com/read/27778325/a-possible-link-between-famine-exposure-in-early-life-and-future-risk-of-gastrointestinal-cancers-implications-from-age-period-cohort-analysis
#10
Shao-Hua Xie, Jesper Lagergren
The Chinese famine in 1958-1962 was one of the worst in human history, but its potential influence on cancer risks is uncertain. Using cancer incidence data in Shanghai, China, during 1983-2007, we calculated age-specific incidence rates of gastrointestinal cancers in birth cohorts exposed to the Chinese famine in different periods of life and a non-exposed reference cohort. Age-period-cohort regressions estimated the overall relative risks of gastrointestinal cancers in each birth cohort. A total of 212,098 new cases of gastrointestinal cancer were identified during the study period (129,233 males and 82,865 females), among whom 18,146 had esophageal cancer, 71,011 gastric cancer, 55,864 colorectal cancer, 42,751 liver cancer, 9,382 gallbladder cancer and 14,944 had pancreatic cancer...
February 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27696082/the-association-between-china-s-great-famine-and-risk-of-breast-cancer-according-to-hormone-receptor-status-a-hospital-based-study
#11
Aliya Alimujiang, Miao Mo, Ying Liu, Nai-Si Huang, Guangyu Liu, Wanghong Xu, Jiong Wu, Zhen-Zhou Shen, Zhimin Shao, Graham A Colditz
PURPOSE: The Great Chinese Famine afflicted almost all Chinese people between 1959 and 1961. No study has explicitly assessed the association between an exposure to Chinese Famine and risk of overall breast cancer and tumor subtype. We evaluated the unique historical environmental influences of famine exposure on breast cancer subtypes. METHODS: 16,469 Chinese women who were diagnosed with invasive breast cancer in the Fudan University Shanghai Cancer Center (FUSCC) from 1999 to 2014 were analyzed...
November 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27629572/exposure-to-the-chinese-famine-in-childhood-increases-type-2-diabetes-risk-in-adults
#12
Jing Wang, Yaru Li, Xu Han, Bing Liu, Hua Hu, Fei Wang, Xiulou Li, Kun Yang, Jing Yuan, Ping Yao, Xiaoping Miao, Sheng Wei, Youjie Wang, Yuan Liang, Xiaomin Zhang, Huan Guo, Handong Yang, Frank B Hu, Tangchun Wu, Meian He
BACKGROUND: Evidence shows that exposure to poor conditions in early life is associated with an increased risk of chronic diseases in adults. OBJECTIVE: We investigated whether exposure to the Chinese famine (1959-1961) in the fetal stage or in childhood (0-9 y) was associated with type 2 diabetes (T2D) and hyperglycemia in adulthood. METHODS: We included 7801 subjects aged 56.4 ± 3.3 y from the Dongfeng-Tongji cohort. Subjects were classified into late-, middle-, and early-childhood-exposed, fetal-exposed, and unexposed groups...
September 14, 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27607452/exposure-to-the-chinese-famine-in-early-life-and-hypertension-prevalence-risk-in-adults
#13
Caizheng Yu, Jing Wang, Yaru Li, Xu Han, Hua Hu, Fei Wang, Jing Yuan, Ping Yao, Xiaoping Miao, Sheng Wei, Youjie Wang, Weihong Chen, Yuan Liang, Xiaomin Zhang, Huan Guo, Handong Yang, Tangchun Wu, Meian He
OBJECTIVES: Famine exposure in early life has been reported to be associated with higher risk of hypertension prevalence in adults. The aim of the present study was to investigate the association of exposure to the Chinese famine during early life with the risk of hypertension prevalence in adults. METHODS: There were 8742 participants born between 1952 and 1964 derived from the Dongfeng-Tongji cohort included in the present study. Participants were classified as nonexposed group, fetal exposed group, early-childhood exposed group, mid-childhood exposed group, and late-childhood exposed group, respectively...
January 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/27606796/prenatal-undernutrition-and-autonomic-function-in-adulthood
#14
Susanne R de Rooij, Alexander Jones, David I Phillips, Clive Osmond, John M Karemaker, Tessa J Roseboom, Rebecca C Painter
OBJECTIVES: Early-life adversity has been shown to be associated with cardiovascular disease and mortality in later life, but little is known about the mechanisms that underlie this association. Prenatal undernutrition, a severe early-life stressor, is associated with double the risk of coronary heart disease and increased blood pressure responses to psychological stress. In the present study, we tested the hypothesis that prenatal undernutrition induces alterations in the autonomic nervous system, which may increase the risk of developing heart disease...
November 2016: Psychosomatic Medicine
https://www.readbyqxmd.com/read/27585673/pre-adult-famine-exposure-and-subsequent-colorectal-cancer-risk-in-women
#15
Morris P Brand, Petra H M Peeters, Carla H van Gils, Sjoerd G Elias
BACKGROUND: Nutritional deprivation during growth and development may contribute to colorectal cancer (CRC) risk in later life. METHODS: We studied 7906 women who were aged 0-21 years during the 1944-45 Dutch famine, who enrolled in the Prospect-EPIC study between 1993 and 1997. We used Cox proportional hazard analyses to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for colorectal (proximal, distal and rectal) cancer risk across self-reported famine exposure and exposure-age categories, while adjusting for potential confounders...
August 31, 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/27539791/the-long-term-health-effects-of-fetal-malnutrition-evidence-from-the-1959-1961-china-great-leap-forward-famine
#16
Seonghoon Kim, Belton Fleisher, Jessica Ya Sun
We report evidence of long-term adverse health impacts of fetal malnutrition exposure of middle-aged survivors of the 1959-1961 China Famine using data from the China Health and Retirement Longitudinal Study. We find that fetal exposure to malnutrition has large and long-lasting impacts on both physical health and cognitive abilities, including the risks of suffering a stroke, physical disabilities in speech, walking and vision, and measures of mental acuity even half a century after the tragic event. Our findings imply that policies and programs that improve the nutritional status of pregnant women yield benefits on the health of a fetus that extend through the life cycle in the form of reduced physical and mental impairment...
August 19, 2016: Health Economics
https://www.readbyqxmd.com/read/27471454/association-between-exposure-to-the-chinese-famine-in-different-stages-of-early-life-and-decline-in-cognitive-functioning-in-adulthood
#17
Chao Wang, Yu An, Huanling Yu, Lingli Feng, Quanri Liu, Yanhui Lu, Hui Wang, Rong Xiao
OBJECTIVE: To investigate whether exposure to the Chinese Famine in different life stages of early life is associated with cognitive functioning decline in adulthood. METHODS: We recruited 1366 adults born between 1950 and 1964 and divided them into fetal-exposed, early childhood-exposed (1-3 years old during the famine), mid childhood-exposed (4-6 years old during the famine), late childhood-exposed (7-9 years old during the famine), and non-exposed groups. A selection of cognitive tests was administered to assess their cognitive performance...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27435863/can-genetic-evidence-help-us-to-understand-the-fetal-origins-of-type-2-diabetes
#18
EDITORIAL
Rachel M Freathy
Lower birthweight is consistently associated with a higher risk of type 2 diabetes in observational studies, but the mechanisms underlying this association are not fully understood. Animal models and studies of famine-exposed populations have provided support for the developmental origins hypothesis, under which exposure to poor intrauterine nutrition results in reduced fetal growth and also contributes to the developmental programming of later type 2 diabetes risk. However, testing this hypothesis is difficult in human studies and studies aiming to do so are mostly observational and have limited scope for causal inference due to the presence of confounding factors...
September 2016: Diabetologia
https://www.readbyqxmd.com/read/27401522/prenatal-famine-exposure-has-sex-specific-effects-on-brain-size
#19
Susanne R de Rooij, Matthan W A Caan, Dick F Swaab, Aart J Nederveen, Charles B Majoie, Matthias Schwab, Rebecca C Painter, Tessa J Roseboom
Early nutritional deprivation might cause irreversible damage to the brain. Prenatal exposure to undernutrition has been shown to be associated with increased central nervous system anomalies at birth and decreased cognitive function in adulthood. Little is known about the potential effect on the brain in older age. We investigated brain size and structure at age 68 years after prenatal famine exposure. T1-weighted structural magnetic resonance images of the brain were made in 118 Dutch famine birth cohort members...
August 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/27244088/exposure-to-famine-at-a-young-age-and-unhealthy-lifestyle-behavior-later-in-life
#20
Heidi P Fransen, Petra H M Peeters, Joline W J Beulens, Jolanda M A Boer, G Ardine de Wit, N Charlotte Onland-Moret, Yvonne T van der Schouw, H Bas Bueno-de-Mesquita, Jeljer Hoekstra, Sjoerd G Elias, Anne M May
BACKGROUND: A healthy diet is important for normal growth and development. Exposure to undernutrition during important developmental periods such as childhood and adolescence can have effects later in life. Inhabitants of the west of the Netherlands were exposed to severe undernutrition during the famine in the last winter of the second World War (1944-1945). OBJECTIVE: We investigated if exposure of women to the Dutch famine during childhood and adolescence was associated with an unhealthy lifestyle later in life...
2016: PloS One
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