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https://www.readbyqxmd.com/read/29221761/enrichment-of-pha-producing-bacteria-under-continuous-substrate-supply
#1
Leonie Marang, Mark C M van Loosdrecht, Robbert Kleerebezem
To enrich polyhydroxyalkanoate (PHA) producing microbial communities, generally, a feast-famine regime is applied. Here we investigated the impact of continuous substrate feeding on the enrichment of PHA-producing bacteria in two sequencing batch reactors (SBRs). In the first reactor, the substrate (acetate) was dosed continuously and Zoogloea sp. was enriched. The culture accumulated PHA upon exposure to excess carbon, but the PHA production rate and storage capacity (53wt.%) were one-fifth of that observed for enrichment cultures in a standard, pulse-fed SBR dominated by the PHA producer Plasticicumulans acidivorans...
December 5, 2017: New Biotechnology
https://www.readbyqxmd.com/read/29207944/incidence-of-breast-cancer-in-chinese-women-exposed-to-the-1959-1961-great-chinese-famine
#2
Dandan He, Yuan Fang, Marc J Gunter, Dongli Xu, Yanping Zhao, Jie Zhou, Hong Fang, Wang Hong Xu
BACKGROUND: The association of malnutrition in early life with breast cancer risk has been studied in Europe by investigating survivors of the Dutch Hunger Winter Famine, but not in China. We evaluated the effect of exposure to the 1959-1961 Great Leap Forward famine on subsequent breast cancer risk in Chinese women. METHODS: A total of 59,060 women born in 1955~1966 were recruited from Minhang district, Shanghai, China, during the period 2008 to 2012. A baseline survey was conducted to collect demographic characteristics and known risk factors for breast cancer...
December 5, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29198238/the-effect-of-adverse-intrauterine-conditions-early-childhood-growth-and-famine-exposure-on-age-at-menopause-a-systematic-review
#3
S Sadrzadeh, M Verschuuren, L J Schoonmade, C B Lambalk, R C Painter
When the follicle reserve, which is developed solely during the fetal period, is depleted, women enter menopause. Intrauterine and childhood adverse conditions might affect the ovarian capacity by influencing follicle production in the first trimester, limiting the initial follicle pool or mediate an accelerated follicular loss thereafter. To investigate if adverse early life influences result in younger age at menopause, the following online databases were systematically searched: PubMed, EMBASE, CINHAL (EBSCO) and Cochrane library (Wiley) up to 1 January 2017...
December 4, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29165159/increase-in-the-prevalence-of-hypertension-among-adults-exposed-to-the-great-chinese-famine-during-early-life
#4
Lingli Liu, Xianglong Xu, Huan Zeng, Yong Zhang, Zumin Shi, Fan Zhang, Xianqing Cao, Yao Jie Xie, Cesar Reis, Yong Zhao
OBJECTIVE: This study aimed to assess the association between exposure to the Great Chinese Famine (1959-1961) during early life and hypertension in adulthood. METHODS: From July to September 2009, 1224 eligible adults were recruited in a cross-sectional survey using a multi-stage stratified random sampling method in Chongqing China. A questionnaire was used to collect information of hypertension and sociodemographic factors. Participants were categorized as childhood, fetal, and none exposure to famine based on the date of birth...
August 25, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29161448/prenatal-famine-exposure-adulthood-obesity-patterns-and-risk-of-type-2-diabetes
#5
Ruogu Meng, Jun Lv, Canqing Yu, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Hui Zhang, Xiaofang Chen, Junshi Chen, Zhengming Chen, Lu Qi, Liming Li
Background: Prenatal exposure to famine and adulthood obesity have been independently related to the risk of type 2 diabetes; however, little is known about the joint effects of these risk factors at different stages of life on adulthood diabetes risk. Methods: The analysis included 88 830 participants of the China Kadoorie Biobank, who were born around the time of the Chinese Great Famine and without diabetes, cardiovascular diseases, or cancer at baseline. We defined famine exposure subgroups as nonexposed (born between 1 October 1962 and 30 September 964), fetal-exposed (born between 1 October 1959 and 30 September 1961) and early-childhood exposed (born between 1 October 1956 and 30 September 1958)...
November 17, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29126190/early-life-exposure-to-china-s-1959-61-famine-and-midlife-cognition
#6
Hongwei Xu, Zhenmei Zhang, Lydia Li, Jinyu Liu
Background: Existing studies of the 1944-45 Dutch famine found little evidence of the association between early life malnutrition and midlife cognition. Methods: Among 2446 rural participants born between 1958 and 1963 in the China Health and Retirement Longitudinal Study, we examined effects of exposure to China's 1959-61 Great Leap Forward famine during prenatal and early postnatal life, on four cognitive measures in 2011 (baseline) and changes in cognition between 2011 and 2013 (first follow-up)...
November 7, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29125320/prenatal-famine-exposure-and-mental-health-in-later-midlife
#7
Thijs van den Broek, Maria Fleischmann
OBJECTIVES: Maternal malnutrition during pregnancy may have long-lasting effects on offspring's mental health. We investigate the effect of prenatal exposure to the Dutch famine (mid November 1944 to late April 1945) on mental health in later mid-life. METHODS: Data are from the Netherlands Kinship Panel Study (n = 642). We use difference-in-difference analyses to compare mental health in later midlife (measured with the MHI-5 index) across three cohorts ('pre-famine cohort', 'famine cohort', 'post-famine cohort') and across two regions (famine affected cities vs...
November 10, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/29101088/effect-of-methylene-blue-induced-photodynamic-therapy-on-a-streptococcus-mutans-biofilm-model
#8
Mariana Alencar Nemezio, Sofia Sampaio de Souza Farias, Maria Cristina Borsatto, Carolina Patrícia Aires, Silmara Aparecida Milori Corona
BACKGROUND: Several studies have reported the use of antimicrobial photodynamic therapy (aPDT) to control biofilm but its efficacy depends on several factors, such as biofilm model used. This study aims to examine whether exposure to diode laser combined with methylene blue affects the bacterial viability and polysaccharide content in a Streptococcus mutans cariogenic biofilm model, which simulated 'feast-famine' episodes of exposure to sucrose that occur in the oral cavity. MATERIALS AND METHODS: S...
October 31, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29074280/premature-brain-aging-in-humans-exposed-to-maternal-nutrient-restriction-during-early-gestation
#9
Katja Franke, Christian Gaser, Susanne R de Rooij, Matthias Schwab, Tessa J Roseboom
BACKGROUND: Prenatal exposure to undernutrition is widespread in both developing and industrialized countries, causing irreversible damage to the developing brain, resulting in altered brain structure and decreased cognitive function during adulthood. The Dutch famine in 1944/45 was a humanitarian disaster, now enabling studies of the effects of prenatal undernutrition during gestation on brain aging in late adulthood. METHODS: We hypothesized that study participants prenatally exposed to maternal nutrient restriction (MNR) would demonstrate altered brain structure resembling premature brain aging in late adulthood, expecting the effect being stronger in men...
October 23, 2017: NeuroImage
https://www.readbyqxmd.com/read/29074165/early-life-undernutrition-and-adult-height-the-dutch-famine-of-1944-45
#10
F R M Portrait, T F van Wingerden, D J H Deeg
Current research shows strong associations between adult height and several positive outcomes such as higher cognitive skills, better earning capacity, increased chance of marriage and better health. It is therefore relevant to investigate the determinants of adult height. There is mixed evidence on the effects of undernutrition during early life on adult height. Therefore, our study aims at assessing the impact of undernutrition during gestation and at ages younger than 15 on adult height. We used data from the Longitudinal Aging Study Amsterdam...
October 18, 2017: Economics and Human Biology
https://www.readbyqxmd.com/read/29055916/the-great-chinese-famine-exposure-in-early-life-and-the-risk-of-nonalcoholic-fatty-liver-disease-in-adult-women
#11
Xiaoya Zheng, Wei Ren, Lilin Gong, Jian Long, Rong Luo, Yonghong Wang
INTRODUCTION AND AIM: Previous studies found famine exposure was associated with a higher risk of metabolic syndrome (MetS). In the study, we investigated the relationship between Chinese famine exposure and the risk of nonalcoholic fatty liver disease (NAFLD) in adult women. MATERIALS AND METHODS: Data were obtained from subjects via routine physical examinations in the Public Health Center of our hospital between 2011 and 2014. Women were categorized into the following three groups: control, prenatally exposed, and postnatally exposed...
October 16, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28731930/early-life-exposure-to-chinese-famine-modifies-the-association-between-hypertension-and-cardiovascular-disease
#12
Zumin Shi, Stephen J Nicholls, Anne W Taylor, Dianna J Magliano, Sarah Appleton, Paul Zimmet
OBJECTIVE: Studies have shown that famine exposure during early life may increase the risk of cardiovascular disease (CVD), hypertension, and diabetes during adulthood. We aimed to assess whether exposure to the Chinese famine (1959-1961) modifies the association between hypertension and CVD. METHODS: We investigated data of 5772 adults born between 1954 and 1964 from the China Health and Retirement Longitudinal Study. CVD was based on self-reported doctor's diagnosis of heart problems (heart attack, coronary heart disease, angina, congestive heart failure, or other heart problems) and stroke...
July 20, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28659214/the-risk-of-stroke-after-prenatal-exposure-to-famine
#13
J Horenblas, S R de Rooij, T J Roseboom
Prenatal exposure to famine is associated with an increased risk of metabolic and cardiovascular diseases in the offspring at adult age. The aim of this study was to assess whether prenatal exposure to undernutrition increases the risk of stroke. This study was performed in the Dutch famine birth cohort, which consist of 2414 members who were born between 1943 and 1947 in the Netherlands. In a subsample of 1177 individuals, interviews were conducted using standardized questionnaires to obtain information about medical history (which included specific questions regarding stroke) and lifestyle...
June 29, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28610568/fetal-and-infant-exposure-to-severe-chinese-famine-increases-the-risk-of-adult-dyslipidemia-results-from-the-china-health-and-retirement-longitudinal-study
#14
Zhenghe Wang, Changwei Li, Zhongping Yang, Jun Ma, Zhiyong Zou
BACKGROUND: To explore the associations between the Chinese famine exposure in early life and the dyslipidemia in adulthood. METHODS: We selected 2752 participants from the baseline survey of China Health and Retirement Longitudinal Study (CHARLS) 2011-2012 to evaluate the associations of early life the Chinese famine exposure with risk of dyslipidemia in adulthood. Dyslipidemia was defined as TC (Total Cholesterol): HDL-C (High-Density Lipoprotein Cholesterol) ratio ≥ 5...
June 14, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28586274/famine-exposure-during-early-life-and-risk-of-hypertension-in-adulthood-a-meta-analysis
#15
Xueling Xin, Jie Yao, Feng Yang, Dongfeng Zhang
Background Many epidemiologic studies have explored the association between famine exposure and the risk of hypertension, but the results remain controversial. Objective A meta-analysis was performed to determine the association between early life famine exposure, fetal famine exposure, and childhood famine exposure and risk of hypertension. Methods A literature search was performed in PubMed, Web of science, Embase and China National Knowledge Infrastructure for relevant articles published up to October 2016...
June 6, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28576899/association-between-exposure-to-the-chinese-famine-during-infancy-and-the-risk-of-self-reported-chronic-lung-diseases-in-adulthood-a-cross-sectional-study
#16
Zhenghe Wang, Zhiyong Zou, Zhongping Yang, Yanhui Dong, Jun Ma
OBJECTIVE: To examine the association between early-life exposure to the Chinese famine and the risk of chronic lung diseases in adulthood. DESIGN: Data analysis from a cross-sectional survey. SETTING AND PARTICIPANTS: 4135 subjects were enrolled into the study from the China Health and Retirement Longitudinal Study (CHARLS) 2011-2012 baseline survey to analyse the associations between prenatal and early postnatal famine exposure and the risk of chronic lung diseases in adulthood...
June 2, 2017: BMJ Open
https://www.readbyqxmd.com/read/28526850/drought-and-child-mortality-a-meta-analysis-of-small-scale-surveys-from-ethiopia
#17
Tefera Darge Delbiso, Chiara Altare, Jose Manuel Rodriguez-Llanes, Shannon Doocy, Debarati Guha-Sapir
Despite the intuitive connection between drought and mortality, we still lack a sound quantitative synthesis of evidence drawn from the available data. In this study, we estimate the pooled under-five death rates (U5DR) and assess the effect of drought on child death in Ethiopia. Small-scale mortality surveys were searched from the Complex Emergency Database and then aggregated spatially and temporally with drought exposure data from the Global Drought Monitor and food insecurity data from the Famine Early Warning Systems Network...
May 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28521622/exodus-from-hunger-the-long-term-health-consequences-of-the-1959-1961-chinese-famine
#18
Zhuoni Zhang, Shige Song, Xiaogang Wu
This article examines the long-term health consequences of China's 1959-1961 famine by comparing people who stayed in Guangdong and endured the famine with people who crossed the border to immigrate to Hong Kong and thus escaped the famine. Based on data from the Hong Kong Panel Study of Social Dynamics (HKPSSD) and the China Family Panel Studies (CFPS), we focused on two health indicators-body mass index (BMI) and self-rated health (SRH)-of the cohort born before 1959. Our results show that the stayers who experienced the famine have a lower BMI than the emigrants, and they are likely to have a poor SRH...
2017: Biodemography and Social Biology
https://www.readbyqxmd.com/read/28499082/exacerbation-of-liver-steatosis-following-exposure-to-famine-and-overnutrition
#19
Zhiyuan Ning, Kun Zhang, Li Zhao, You Lu, Honglin Sun, Chi Chen, Xiaomin Nie, Meng Lu, Ningjian Wang, Yingli Lu
SCOPE: People suffering from famine in early life and overnutrition in adulthood may have an increased risk for liver steatosis. We aimed to investigate the effects and mechanisms of early nutrition restriction and overnutrition on de novo lipogenesis in the liver. METHODS AND RESULTS: Three-wk-old male rats were food restricted for 4 wk and refed a high-fat or normal fat diet individually in metabolic cages for 9 wk. Weight-matched groups were also set up. Fatty acid synthetase expression was measured to estimate de novo lipogenesis in the liver...
May 12, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28498832/prenatal-exposure-to-the-great-chinese-famine-and-mid-age-hypertension
#20
Lei Wu, Xueqin Feng, Axin He, Yi Ding, Xiuwen Zhou, Zhice Xu
BACKGROUND: One of the most terrible famines last century was Great Chinese Famine (GCF) in 1959~1961 when millions of people died from starving. Under-nutrition during famine between the Western and Eastern (Dutch Hungry vs. GCF) was similar, while cardiovascular consequences might not be the same. Addressing such questions may gain new insight into prevention of cardiovascular diseases. METHODS: A retrospective cohort of 18,593 participants aged 43-49 years of old, was from Suzhou, China...
2017: PloS One
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