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Traumatic injuries

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https://www.readbyqxmd.com/read/28944949/the-research-progress-of-mesenchymal-stem-cells-in-the-treatment-of-traumatic-brain-injury
#1
Gang Li, Yue Yang, Hua-Jiang Dong, Ling Lin
Traumatic brain injury (TBI) is the leading cause of mortality and morbidity in children and adults throughout the world. It is urgent to ameliorate TBI damage and reduce the disability and case-fatality rate. Stem cell therapy is another medical revolution after drug and surgical medication. Mesenchymal stem cells (MSCs) are a class of cells with significant self-renewal and multi-lineage differentiation properties and be favorable for the treatment of various diseases and injuries, it could be envisioned that MSCs transplantation may be a promising treatment for TBI...
July 16, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28944947/posttraumatic-cerebral-infarction-after-decompressive-craniectomy-for-traumatic-brain-injury-incidence-risk-factors-and-outcome
#2
Tsung-Ming Su, Chu-Mei Lan, Tsung-Han Lee, Fu-Yuan Shih, Shih-Wei Hsu, Cheng-Hsien Lu
AIM: To investigate the incidence, timing, risk factors of posttraumatic cerebral infarction (PTCI) and its influence on mortality in patients with moderate to severe traumatic brain injury (TBI). MATERIAL AND METHODS: After reviewing the medical records and radiographs over a 6-year period, 173 patients with moderate to severe TBI were enrolled to determine the risk factors for the development of PTCI following unilateral decompressive craniectomy (DC). RESULTS: The incidence of PTCI following DC was 31...
July 23, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28944905/myricitrin-decreases-traumatic-injury-of-the-spinal-cord-and-exhibits-antioxidant-and-anti%C3%A2-inflammatory-activities-in-a-rat-model-via-inhibition-of-cox%C3%A2-2-tgf%C3%A2-%C3%AE-1-p53-and-elevation-of-bcl%C3%A2-2-bax-signaling-pathway
#3
Yang Lei
Myricitrin has multiple effects, including antagonism of platelet activating factor, regulation of blood sugar levels, oxidation resistance, protection of the liver and the relieving of ethylism. The present study evaluated how myricitrin weakens traumatic injury of the spinal cord (TISC), and exhibits antioxidant and anti‑inflammatory activities in a rat model. TISC model rats were injected intraperitoneally with 5, 10 or 30 mg/kg/day of myricitrin for 5 days. Basso‑Beattie‑Bresnahan evaluation of locomotion and water content of spinal cord were used to analyze the effects of myricitrin on TISC...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944346/falx-cerebri-segmentation-via-multi-atlas-boundary-fusion
#4
Jeffrey Glaister, Aaron Carass, Dzung L Pham, John A Butman, Jerry L Prince
The falx cerebri is a meningeal projection of dura in the brain, separating the cerebral hemispheres. It has stiffer mechanical properties than surrounding tissue and must be accurately segmented for building computational models of traumatic brain injury. In this work, we propose a method to segment the falx using T1-weighted magnetic resonance images (MRI) and susceptibility-weighted MRI (SWI). Multi-atlas whole brain segmentation is performed using the T1-weighted MRI and the gray matter cerebrum labels are extended into the longitudinal fissure using fast marching to find an initial estimate of the falx...
September 2017: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
https://www.readbyqxmd.com/read/28944084/hope-coping-and-psychosocial-adjustment-after-spinal-cord-injury
#5
Pat Dorsett, Timothy Geraghty, Anne Sinnott, Rick Acland
INTRODUCTION: The study was a prospective, longitudinal design. The purpose was to explore the role of hope in the coping and psychosocial adjustment process following a spinal cord injury. The study was conducted at Spinal cord injury rehabilitation units in Queensland, Australia and Christchurch, New Zealand. MATERIALS AND METHODS: This was a longitudinal study conducted in two SCI rehabilitation centres, one in Australia and one in New Zealand. A total of 47 participants with newly acquired traumatic SCI were administered a survey consisting of the Adult Hope Scale; the Moorong Self-Efficacy Scale; the Centre for Epidemiology Studies-Depression Scale (CES-D); Life Satisfaction, Self-Rated Adjustment and Life Problems Subscales of the Life Situation Questionnaire and selected subscales from the Spinal Cord Lesion-related Coping Strategies Questionnaire (SCL-CSQ) and the COPE scales at 6 weeks post injury and 3 months post discharge...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28943422/epidemiology-management-and-functional-outcomes-of-traumatic-brain-injury-in-sub-saharan-africa
#6
Jessica Eaton, Asma Bilal Hanif, Joanna Grudziak, Anthony Charles
BACKGROUND: Trauma accounts for 4.7 million deaths each year, with an estimated 90% of these occurring in LMICs. Approximately half of trauma-related deaths are due to central nervous system injury. OBJECTIVE: Because a thorough understanding of TBI in LMICs is essential to mitigate TBI-related mortality, we established a clinical and radiographic database to characterize TBI in our low-income setting. METHODS: This is a review of prospectively collected data from Kamuzu Central Hospital, a tertiary care center in the capital of Malawi...
September 21, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28943289/serum-lipocalin-2-concentrations-and-mortality-of-severe-traumatic-brain-injury
#7
Liang-Jun Shen, Jing Zhou, Mi Guo, Chun-Song Yang, Qi-Chen Xu, Qing-Wei Lv, Song-Bin Yang, Hang-Bin Huang
BACKGROUND: Lipocalin-2 is related to acute brain injury. We assessed the prognostic value of serum lipocalin-2 in head trauma. METHODS: Blood samples were collected from 115 controls and 115 patients with severe traumatic brain injury. Trauma severity was assessed by Glasgow Coma Scale (GCS) scores at baseline. Thirty-day mortality and overall survival time were recorded. RESULTS: Compared with the controls, serum lipocalin-2 concentrations were significantly increased in the patients...
September 21, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28943199/effects-of-the-dimeric-psd-95-inhibitor-uccb01-144-on-functional-recovery-after-fimbria-fornix-transection-in-rats
#8
Jens Bak Sommer, Anders Bach, Hana Malá, Kristian Strømgaard, Jesper Mogensen, Darryl S Pickering
Pharmacological inhibition of PSD-95 is a promising therapeutic strategy in the treatment of stroke, and positive effects of monomeric and dimeric PSD-95 inhibitors have been reported in numerous studies. However, whether therapeutic effects will generalize to other types of acute brain injury such as traumatic brain injury (TBI), which has pathophysiological mechanisms in common with stroke, is currently uncertain. We have previously found a lack of neuroprotective effects of dimeric PSD-95 inhibitors in the controlled cortical impact model of TBI in rats...
September 21, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28943007/thoracic-endovascular-aortic-repair-migration-and-aortic-elongation-differentiated-using-dual-reference-point-analysis
#9
Hillary B Alberta, Toshio Takayama, Annalise Panthofer, Richard P Cambria, Mark A Farber, William D Jordan, Jon S Matsumura
OBJECTIVE: We evaluated images of patients undergoing a thoracic endovascular aortic repair procedure using two reference points as a means for differentiating stent graft migration from aortic elongation. Conventional standards define migration of a stent graft as an absolute change in the distance from the distal graft ring to a distal landmark ≥10 mm compared with a baseline measurement. Aortic elongation occurs over time in both healthy individuals and patients with aortic disease...
September 21, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28942681/the-factor-structure-of-the-disability-rating-scale-in-individuals-with-traumatic-brain-injury
#10
Denise Krch, Anthony H Lequerica
PURPOSE: To examine the factor structure of the Disability Rating Scale and the predictive validity of the scale's factors among individuals with traumatic brain injury. MATERIALS AND METHODS: Five hundred and eight individuals with moderate-to-severe traumatic brain injury were administered the Disability Rating Scale. The sample was randomly divided into two groups. An exploratory factor analysis was conducted on Group 1, and a confirmatory factor analysis on Group 2...
September 23, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28942474/svct2-expression-and-function-in-reactive-astrocytes-is-a-common-event-in-different-brain-pathologies
#11
Katterine Salazar, Fernando Martínez, Margarita Pérez-Martín, Manuel Cifuentes, Laura Trigueros, Luciano Ferrada, Francisca Espinoza, Natalia Saldivia, Romina Bertinat, Katherine Forman, María José Oviedo, Antonio J López-Gambero, Christian Bonansco, Ernesto R Bongarzone, Francisco Nualart
Ascorbic acid (AA), the reduced form of vitamin C, acts as a neuroprotector by eliminating free radicals in the brain. Sodium/vitamin C co-transporter isoform 2 (SVCT2) mediates uptake of AA by neurons. It has been reported that SVCT2 mRNA is induced in astrocytes under ischemic damage, suggesting that its expression is enhanced in pathological conditions. However, it remains to be established if SVCT expression is altered in the presence of reactive astrogliosis generated by different brain pathologies. In the present work, we demonstrate that SVCT2 expression is increased in astrocytes present at sites of neuroinflammation induced by intracerebroventricular injection of a GFP-adenovirus or the microbial enzyme, neuraminidase...
September 23, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28942245/regulatory-role-of-nadph-oxidase-2-in-the-polarization-dynamics-and-neurotoxicity-of-microglia-macrophages-after-traumatic-brain-injury
#12
Jing Wang, Merry W Ma, Krishnan M Dhandapani, Darrell W Brann
Traumatic brain injury (TBI) is a leading cause of death and disability. Secondary injuries that develop after the initial trauma contribute to long-lasting neurophysiological deficits. Polarization of microglia/macrophages toward a pro-inflammatory (M1) phenotype may increase the progression of secondary injury following TBI; however, the regulatory and functional mechanisms underlying these changes remain poorly defined. In the present study, we showed elevated expression of NADPH oxidase 2 (NOX2) and activation of nuclear factor-kappa B (NF-κB) predominantly in microglia/macrophages at 4- and 7-days after controlled cortical impact in mice...
September 20, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28942078/tau-protein-mapt-as-a-possible-biochemical-marker-of-traumatic-brain-injury-in-postmortem-examination
#13
Mieszko Olczak, Justyna Niderla-Bielińska, Magdalena Kwiatkowska, Dorota Samojłowicz, Sylwia Tarka, Teresa Wierzba-Bobrowicz
MAPT is a neuronal protein that plays an important role in axonal stabilization, neuronal development, and neuronal polarity. MAPT release into the CSF and blood has been interpreted as indicative of axonal injury as its elevated levels were observed in olympic boxers even after a mild head trauma suggesting minor CNS injuries. In our study we wanted to check the potential relevance of MAPT examination for forensic purposes. The study was carried out using cases of head injury group and cases of sudden death (cardiopulmonary failure, no injuries of the head - control group) provided by forensic pathologists at the Department of Forensic Medicine, Medical University of Warsaw...
September 15, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28942041/quality-of-life-following-road-traffic-injury-a-systematic-literature-review
#14
Ritva Rissanen, Hans-Yngve Berg, Marie Hasselberg
PURPOSE: To assess and provide a systematic overview of current knowledge about the relationship between quality of life (QoL) and road traffic injury, and to appraise how QoL is affected by road traffic injury. METHODS: A systematic review of the literature published since 1990 on QoL after a road traffic injury, including adult and paediatric populations, from three databases (Pubmed, PsychInfo and SafetyLit) was undertaken. The methodological quality was assessed according to the Newcastle-Ottawa Quality Assessment Scale...
September 19, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28941987/burn-injury-challenges-and-advances-in-burn-wound-healing-infection-pain-and-scarring
#15
Yiwei Wang, Joanneke Beekman, Jonathan Hew, Stuart Jackson, Andrea C Issler-Fisher, Roxanne Parungao, Sepher S Lajevardi, Zhe Li, Peter K M Maitz
Severe burn injuries are the most traumatic and physically debilitating injuries affecting nearly every organ system and leading to significant morbidity and mortality. Early burn wound excision and skin grafting are common clinical practices that have significantly improved the outcomes for severe burn injured patients by reducing mortality rate and days of hospital stay. However, slow wound healing, infection, pain, and hypertrophic scarring continue to remain a major challenge in burn research and management...
September 20, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28941968/popliteal-pseudoaneurysm-and-arteriovenous-fistula-after-arthroscopic-anterior-and-posterior-cruciate-ligament-reconstruction-a-case-report
#16
Ding Xu, Liefeng Ji, Jiang Zhu, Yuefeng Xie
INTRODUCTION: Vascular injuries are a well recognised but very rare complication of surgery or trauma around the knee, especially associated with arthroscopic anterior and posterior cruciate ligament reconstruction. PRESENTATION OF CASE: This report describes a case of a Popliteal pseudoaneurysm and arteriovenous fistula after Arthroscopic anterior and Posterior Cruciate Ligament Reconstruction. An 57-year-old male who complained of pain and swelling around the left lower extremity after the ACL and PCL reconstruction using a semitendinosus graft from the two limbs caused by bicycle accident...
August 10, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28941865/effect-of-curcumin-on-acute-spinal-cord-injury-in-mice-via-inhibition-of-inflammation-and-tak1-pathway
#17
Nanwen Zhang, Guicai Wei, Jian Ye, Lin Yang, Yunda Hong, Guisheng Liu, Huifen Zhong, Xinyi Cai
BACKGROUND: Traumatic spinal cord injury (SCI) is damage to the spinal cord that results in damaged spinal cord function. As a natural compound, curcumin has recently been shown to have anti-inflammatory and strong antioxidant activities. To investigate the effect of curcumin against acute spinal cord injury (SCI), we explored its induced effects in SCI mice. Transforming growth factor (TGF)-activated kinase 1 (TAK1) is a member of the MAPKKK family and plays an essential role in TNF, IL-1, and Toll-like receptor (TLR) signaling pathways...
February 14, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28941811/reversible-induction-of-tdp-43-granules-in-cortical-neurons-after-traumatic-injury
#18
Diana Wiesner, Lilla Tar, Birgit Linkus, Akila Chandrasekar, Florian Olde Heuvel, Luc Dupuis, William Tsao, Philip C Wong, Albert Ludolph, Francesco Roselli
Traumatic brain injury (TBI) has been proposed as a risk factor for neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). To determine whether TBI might trigger or exacerbate ALS-relevant pathology, we delivered a mild stab-wound injury to the motor cortex of three different ALS mouse models expressing mutations in SOD1, TDP-43 or FUS and scrutinized the effects on the formation of phospho-TDP-43 (pTDP-43) cytoplasmic granules. Stab-injury induced the formation of cytoplasmic TDP-43 granules in wt animals, peaking at 3dpi; a much larger response was seen in mutant TDP-43 mice, whose response peaked at 7dpi...
September 20, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28941568/resuscitation-thoracotomy
#19
G Boddaert, E Hornez, H De Lesquen, A Avramenko, B Grand, T MacBride, J-P Avaro
Resuscitation thoracotomy is a rarely performed procedure whose use, in France, remains marginal. It has five specific goals that correspond point-by-point to the causes of traumatic cardiac arrest: decompression of pericardial tamponade, control of cardiac hemorrhage, performance of internal cardiac massage, cross-clamping of the descending thoracic aorta, and control of lung injuries and other intra-thoracic hemorrhage. This approach is part of an overall Damage Control strategy, with a targeted operating time of less than 60minutes...
September 20, 2017: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/28941502/neurosurgical-considerations-in-craniofacial-trauma
#20
REVIEW
Robert Glenn Oxford, Randall Matther Chesnut
Spinal and traumatic brain injuries (TBIs) often accompany craniofacial trauma. Neurosurgical considerations can range from initial emergent surgery to conservative management of closed head injuries in patients with craniofacial injuries. This article discusses the most common disorders managed by neurosurgeons in the setting of craniofacial trauma, and reviews the usual timing and setting for various treatments that patients with TBI encounter throughout the course of treatment. It also highlights the consequences of TBI on the timing and planning of craniofacial repairs and the importance of multidisciplinary cooperation to provide comprehensive care to survivors of trauma...
November 2017: Facial Plastic Surgery Clinics of North America
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