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Activity monitors

Manda Curic, Marina Juribašić Kulcar, Alen Bjelopetrović, Stipe Lukin, Ivan Halasz, Krunoslav Užarević, Ivica Đilović, Dajana Barišić, Ana Budimir
Mechanism of C-H bond activation by various Pd(II) catalysts under milling conditions has been studied by in situ Raman spectroscopy. Common Pd(II) precursors, i.e. PdCl₂, [Pd(OAc)₂]₃, PdCl₂(MeCN)₂ and [Pd(MeCN)₄][BF₄]₂, have been employed for the activation of one or two C-H bonds in an unsymmetrical azobenzene substrate. The C-H activation was achieved by all used Pd(II) precursors and their reactivity increases in the order [Pd(OAc)₂]₂ < PdCl₂(MeCN)₂ < PdCl₂ < [Pd(MeCN)₂][BF₄]₂...
June 19, 2018: Chemistry: a European Journal
Ami Schattner
We review the prevalence, predictability, prognosis, and preventability of atrial fibrillation and associated cardiogenic brain embolism, focusing on 'silent' subclinical atrial fibrillation (SCAF) which is very common in the elderly, and associated with significantly increased risk of stroke and cardiovascular mortality. The current paradigm treats atrial fibrillation once discovered by its symptoms, complications (stroke) or by chance, and screening recommendations are limited to opportunistic pulse palpation...
June 18, 2018: QJM: Monthly Journal of the Association of Physicians
Yi Tang, GaoMing Xiao, YueJun Chen, Yu Deng
Long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) functions as a crucial regulator of metastasis in lung cancer. The aim of this study is to unravel the underlying mechanisms of lncRNA MALAT1 in non-small-cell lung cancer (NSCLC). A cohort of 36 NSCLC tumor tissues and adjacent normal tissues was collected postoperatively from patients with NSCLC. qRT-PCR was performed to detect the expression of MALAT1 in both NSCLC tissues and cell lines. Cell migration and invasion were monitored by wound healing assay and transwell invasion assay...
June 18, 2018: Anti-cancer Drugs
Carlos J Leitão, Juan Rafael Lima-Rodríguez, Fatima Ferreira, Catarina Avelino, Francisco M Sánchez-Margallo, Luís Antunes
BACKGROUND: Evaluation of nociceptive-antinociceptive balance during general anesthesia is still challenging and routinely based on clinical criteria. Analgesic drug delivered may be optimized with parasympathetic tone activity (PTA) monitor. This study compares ketorolac and ketorolac/tramadol balance analgesia using a PTA monitor. METHODS: Pain intensity response was assessed using a 0-100 numerical state scale (PTA) after nociceptive stimuli in pigs under stable sevoflurane anesthesia...
June 14, 2018: Anesthesia and Analgesia
Zhihua Chen, Mengzhen Zhang, Yuhuan Qiao, Junjuan Yang, Qinan Yin
BACKGROUND: The human cervical carcinoma oncogenic mechanisms still remain elusive. Thus, we proposed to understand the biological role of a newly discovered therapeutic miRNA. METHODS: MiR-1297 related to human cervical carcinoma was selected for this study. TaqMan qRT- PCR assay was used to profile miRNA, phosphatase and tensin homolog (PTEN) expression in randomly chosen tumour with non-tumour tissues, and the apoptosis factors expression. Cell proliferation was monitored by CCK-8 assay and colony formation assay...
June 19, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Monica Pusineri, Serena Monteleone, Elisabetta De Bernardi, Ambrogina Lanzi, Claudio Lisi, Elena Dalla Toffola, Ettore Carlisi
OBJECTIVES: Hand burn is not a common condition in the clinical practice and needs a long and laboured rehabilitative treatment to restore the lost function. METHODS: This case report illustrates the achievable improvements in mobility and function by using innovative inertial systems for occupational exercise in a Virtual Reality, in addition to a traditional rehabilitative treatment. RESULTS: Through these instruments, we could promote and concurrently assess the recovery of a functional grasp and the ability in the execution of Activities of Daily Living...
November 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
Paulo Lemos, Alexandra Guedes, Joana Mourão, Joaquim Figueiredo Lima, José Veiga, Manuel Chedas, Pedro Branca, Rosário Abrunhosa, Susana Cadilha, Valentina Almeida
INTRODUCTION: The objective of this study is to identify the number of anaesthesiologists working in Portugal and to monitor the national activity of this medical specialty by comparing it with a similar Census performed in 2014. MATERIAL AND METHODS: Observational cross-sectional study. Data related to the month of May 2017 was collected from Anaesthesiology departments of 53 Portuguese public institutions from a total of 86 hospitals. RESULTS: The Census registered 615 127 surgical procedures (3...
May 30, 2018: Acta Médica Portuguesa
He Xiaoyu, Yin Yiru, Shi Shuisheng, Cheng Keyan, Yan Zixing, Cheng Shanglin, Wang Yuan, Cheng Dongming, Zhang Wangliang, Bai Xudong, Ma Jie
OBJECTIVES: Esophageal squamous cell carcinoma is a highly prevalent cancer withpoor survival rate and prognosis. Increasing evidence suggests an important role for metabolic regulation in treating esophageal squamous cell carcinoma, but the underlying mechanism remains unclear. The pyruvate kinase M2 isoform is a key enzyme in the energy production process, and the upregulation of pyruvate kinase M2 isoform also plays a crucial role in gene transcription and tumorigenesis. The mammalian target of rapamycin pathway regulates an array of cellular functions, including protein synthesis, metabolism, and cell proliferation...
January 1, 2018: Technology in Cancer Research & Treatment
Usman Ali, Andrew James Sweetman, Kevin C Jones, Riffat Naseem Malik
This study was designed to monitor organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in riverine water of Lesser Himalaya along the altitude. Further, the sediment-water partitioning employing organic carbon and black carbon models were assessed. Results revealed higher water levels of organochlorine pesticides (0.07-41.4 ng L-1 ) and polychlorinated biphenyls (0.671-84.5 ng L-1 ) in Lesser Himalayan Region (LHR) of Pakistan. Spatially, elevated levels were observed in the altitudinal zone (737-975 masl) which is influenced by anthropogenic and industrial activities...
June 18, 2018: Environmental Science and Pollution Research International
Claus von der Burchard, Felix Treumer, Christoph Ehlken, Stefan Koinzer, Konstantine Purtskhvanidze, Jan Tode, Johann Roider
PURPOSE: Current algorithms for automated computer interpretation of optical coherence tomography (OCT) imaging of patients suffering from neovascular age-related macular degeneration (AMD) mostly rely on fluid detection. However, fluid detection itself and correct interpretation of the fluid currently limits diagnostic accuracy. We therefore performed a detailed analysis of the requirements that would have to be met for fluid detection approaches. We further investigated if monitoring retinal volume would be a viable alternative to detect disease activity...
June 18, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Tanvi Banerjee, Matthew Peterson, Quintin Oliver, Andrew Froehle, Larry Lawhorne
With the introduction of the large number of fitness devices on the market, there are numerous possibilities for their use in managing chronic diseases in older adults. For example, monitoring people with dementia using commercially available devices that measure heart rate, breathing rate, lung volume, step count, and activity level could be used to predict episodic behavioral and psychological symptoms before they become distressing or disruptive. However, since these devices are designed primarily for fitness assessment, validation of the sensors in a controlled environment with the target cohort population is needed...
January 2018: Smart Health
Jung Hwan Lee, Da Hea Seo, Min Jung Nam, Geon Hui Lee, Dong Hee Yang, Min Joo Lee, Ung-Rim Choi, Seongbin Hong
Background: Obesity and related metabolic disorders are growing health challenges worldwide and individuals at military service are not exceptions. The purpose of this study was to examine the prevalence of obesity and metabolic syndrome (MS) in the Korean military and to compare with the general population. Methods: This was a cross-sectional study of 4,803 young military participants who underwent a corporal health-screening program between October 2013 and October 2014...
June 18, 2018: Journal of Korean Medical Science
Sawako Kato, Masahiko Ando, Takaaki Kondo, Yasuko Yoshida, Hiroyuki Honda, Shoichi Maruyama
Modification of lifestyle habits, including diet and physical activity, is essential for the prevention and control of type 2 diabetes mellitus (T2DM) in elderly patients. However, individualized treatment is more critical for the elderly than for general patients. This study aimed to determine lifestyle interventions that resulted in lowering hemoglobin A1c (HbA1c ) in Japanese pre- and early diabetic elderly subjects. The BEST-LIFE trial is an ongoing, open-label, 6-month, randomized (1:1) parallel group trial...
May 2018: Nagoya Journal of Medical Science
Nguk Ting Lo, Mohammad Abul Bashar Sarker, Yvonne Ai Lian Lim, Md Harun-Or-Rashid, Junichi Sakamoto
Providing safe drinking-water to human civilization is indispensable; it is one of the most cost-effective means of reducing the disease burden of diarrhea. Unfortunately, water supply quality monitoring from public water treatment plants (WTPs) is often neglected or taken for granted. To determine the produced water quality, WTPs in Sarawak, Malaysia were assessed for their protozoa removal ability. A self-administered questionnaire based on the regulations in the Drinking-water Standards for New Zealand (DWSNZ) was developed...
May 2018: Nagoya Journal of Medical Science
Manuela Marescotti, Konstantinos Lagogiannis, Barbara Webb, R Wayne Davies, J Douglas Armstrong
We present a bioluminescence method, based on the calcium-reporter Aequorin (AEQ), that exploits targeted transgenic expression patterns to identify activity of specific neural groups in the larval Drosophila nervous system. We first refine, for intact but constrained larva, the choice of Aequorin transgene and method of delivery of the co-factor coelenterazine and assay the luminescence signal produced for different neural expression patterns and concentrations of co-factor, using standard photo-counting techniques...
June 18, 2018: Scientific Reports
Emma Timmins-Schiffman, Molly P Mikan, Ying Sonia Ting, H Rodger Harvey, Brook L Nunn
Assigning links between microbial activity and biogeochemical cycles in the ocean is a primary objective for ecologists and oceanographers. Bacteria represent a small ecosystem component by mass, but act as the nexus for both nutrient transformation and organic matter recycling. There are limited methods to explore the full suite of active bacterial proteins largely responsible for degradation. Mass spectrometry (MS)-based proteomics now has the potential to document bacterial physiology within these complex systems...
June 18, 2018: Scientific Reports
Jace Natzke, Jesse Noar, José M Bruno-Bárcena
Azotobacter vinelandii selectively utilizes three types of nitrogenase (molybdenum, vanadium, and iron-only) to fix N2 with their expression regulated by the presence or absence of different metal cofactors in its environment. Each alternative nitrogenase isoenzyme is predicted to have different electron flux requirements based off in vitro measurements, with the molybdenum nitrogenase requiring the lowest flux and the iron-only nitrogenase requiring the highest. Here, prior characterized strains, de-repressed in nitrogenase synthesis and also deficient in uptake hydrogenase, were further modified to generate new mutants lacking the ability to produce poly-β-hydroxybutyrate (PHB)...
June 18, 2018: Applied and Environmental Microbiology
Magdalena Lopatek, Kinga Wieczorek, Jacek Osek
Vibrio parahaemolyticus is a widespread bacterium in marine environment responsible for gastroenteritis in humans. Food-borne infections are mainly associated with the consumption of contaminated raw or undercooked fish and shellfish. The aim of this study was to determine the antimicrobial resistance, virulence factors and genetic profiles of V. parahaemolyticus isolated from seafood originating from different countries. A total of 104 (17.5%) isolates were recovered from 595 analyzed samples. The isolates were tested for the presence of the tdh and trh genes, involved in the pathogenesis of V...
June 18, 2018: Applied and Environmental Microbiology
Miles B Horton, Giulio Prevedello, Julia M Marchingo, Jie H S Zhou, Ken R Duffy, Susanne Heinzel, Philip D Hodgkin
The generation of cellular heterogeneity is an essential feature of immune responses. Understanding the heritability and asymmetry of phenotypic changes throughout this process requires determination of clonal-level contributions to fate selection. Evaluating intraclonal and interclonal heterogeneity and the influence of distinct fate determinants in large numbers of cell lineages, however, is usually laborious, requiring familial tracing and fate mapping. In this study, we introduce a novel, accessible, high-throughput method for measuring familial fate changes with accompanying statistical tools for testing hypotheses...
June 18, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
Joan Dallinga, Mark Janssen, Jet van der Werf, Ruben Walravens, Steven Vos, Marije Deutekom
BACKGROUND: A large number of people participate in individual or unorganized sports on a recreational level. Furthermore, many participants drop out because of injury or lowered motivation. Potentially, physical activity-related apps could motivate people during sport participation and help them to follow and maintain a healthy active lifestyle. It remains unclear what the quality of running, cycling, and walking apps is and how it can be assessed. Quality of these apps was defined as having a positive influence on participation in recreational sports...
June 18, 2018: JMIR MHealth and UHealth
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