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hypotension espinal

No abstract text is available yet for this article.
January 1955: Revista Española de Oto-neuro-oftalmología y Neurocirugía
No abstract text is available yet for this article.
January 1957: Revista Española de Anestesiología
M Carmignani, A R Volpe, B Botta, R Espinal, S C De Bonnevaux, C De Luca, M Botta, F Corelli, A Tafi, R Sacco, G Delle Monache
The more polar metabolites from the Venezuelan plant Verbesina caracasana, i.e., N(3)-prenylagmatine, (3,4-dimethoxycinnamoyl)-N(1)-agmatine, agmatine, and galegine (prenylguanidine), previously reported (Delle Monache, G.; et al. BioMed. Chem. Lett. 1999, 9, 3249-3254), have been synthesized following a biosynthetic strategy. The pharmacologic profiles of various synthetic analogues of (3,4-dimethoxycinnamoyl)-N(1)-agmatine (G5) were also analyzed, to shed some light on the structure-activity relationship of these compounds...
August 30, 2001: Journal of Medicinal Chemistry
G Delle Monache, A R Volpe, F Delle Monache, A Vitali, B Botta, R Espinal, S C De Bonnevaux, C De Luca, M Botta, F Corelli, M Carmignani
After the isolation of caracasanamide and caracasandiamide, further hypotensive components of Verbesina caracasana were shown to be N3-prenylagmatine, N1-3',4'-dimethoxycinnamoylagmatine, agmatine and galegin (prenylguanidine). The structures were assigned on the basis of the spectral data of both metabolites and products from their alkaline hydrolyses. A pharmacological analysis of these products is also presented.
November 15, 1999: Bioorganic & Medicinal Chemistry Letters
M Carmignani, A R Volpe, F Delle Monache, B Botta, R Espinal, S C De Bonnevaux, C De Luca, M Botta, F Corelli, A Tafi, G Ripanti, G D Monache
Caracasandiamide, a second hypotensive agent isolated from Verbesina caracasana, is the cyclobutane dimer (truxinic type) of the previously reported 1-[(3, 4-dimethoxycinnamoyl)amino]-4-[(3-methyl-2-butenyl)guanidino]butane (caracasanamide) (Delle Monache, G.; et al. BioMed. Chem. Lett. 1992, 25, 415-418). The structure was confirmed by synthesis starting from beta-truxinic acid obtained by photoaddition of 3, 4-dimethoxycinnamic acid. The dimer was coupled with 2 mol of prenylagmatine to give caracasandiamide in satisfactory yield...
August 12, 1999: Journal of Medicinal Chemistry
J G Lainchbury, A M Richards, M G Nicholls, E A Espiner, T G Yandle
Brain natriuretic peptide (BNP) is increased in left ventricular impairment and neutral endopeptidase (NEP) is involved in its metabolism. In random order, eight patients with left ventricular impairment received placebo, a 4-h infusion of human BNP (3.0 pmol/kg min), a single oral dose of NEP inhibitor (SCH 42495, 300 mg), and combined BNP and SCH 42495. Plasma BNP, cGMP, and cortisol were significantly increased by all three treatments (P < 0.05-P < 0.001). Combined treatment had a synergistic effect on plasma cGMP...
February 1999: Journal of Clinical Endocrinology and Metabolism
G Delle Monache, B Botta, F Delle Monache, R Espinal, S C De Bonnevaux, C De Luca, M Botta, F Corelli, M Carmignani
Caracasanamide, one of the hypotensive agents isolated from Verbesina caracasana, is a mixture of (Z)-1a and (E)-1b forms of 1-[(3,4-dimethoxycinnamoyl)amino]-4- [(3-methyl-2-butenyl)-guanidino]butane. The structure of (E)-caracasanamide (1b) was confirmed by high-yielding synthesis starting from N,N'-bis(tert-butoxycarbonyl)-S-methylisothiourea. The water-soluble Z-form of 1a, assayed by i.v. route in anesthetized rats at doses ranging from 50 to 1600 micrograms/kg body weight, was found to decrease blood pressure, to increase cardiac inotropism, respiratory frequency, and tidal volume, and to induce a very slight and not significant tachycardia...
October 1, 1993: Journal of Medicinal Chemistry
G A Wittert, E A Espiner, A M Richards, R A Donald, J H Livesey, T G Yandle
OBJECTIVE: We determined the effects of physiological (non-hypotensive) increments of plasma atrial natriuretic factor (ANF) on the vasopressin and hypothalamic-pituitary-adrenal response to insulin induced hypoglycaemia. DESIGN: Single blind, placebo controlled, randomized study of the effect of vehicle alone or ANF (2.5 pmol/kg/min for 120 minutes) commencing 30 minutes before bolus administration of insulin (0.15 U/kg body weight). RESULTS: ANF infusion raised venous plasma ANF levels four to five-fold (mean level 32 +/- 0...
February 1993: Clinical Endocrinology
C J Charles, E A Espiner, A M Richards
Whereas the short-term effects of atrial natriuretic factor (ANF) are well documented, less is known concerning the possible hypotensive action of sustained low-dose ANF infusions. Accordingly, we have examined the sequential renal, hormonal, and hemodynamic responses to 48-h low-dose ANF infusions in eight normotensive conscious sheep and evaluated the effects of these infusions on autonomic (baroreceptor), adrenocortical, and pressor responsiveness to exogenous stimulation. Plasma ANF levels tended to rise in response to ANF infusions, but the difference between ANF and control day levels was not significantly different...
March 1993: American Journal of Physiology
A M Richards, M G Nicholls, E A Espiner, H Ikram, E J Hamilton, J E Wells, A H Maslowski, T G Yandle
The effects of moderate restriction of dietary sodium and potassium supplementation on plasma levels of renin, angiotensin II, aldosterone, and cortisol and on arterial pressure were studied in 12 patients with mild essential hypertension. To define hormone-blood pressure relationships, venous hormone levels were measured hourly and intra-arterial pressure continuously for 24 hours after 4 to 6 weeks of sodium restriction, 4 to 6 weeks of potassium supplementation, and a similar period of control diet. Our results show that compared with the control diet, moderate sodium restriction was associated with increased levels of aldosterone but no overall change in renin, angiotensin II, or cortisol levels...
September 1985: Hypertension
E A Espiner
The effect of 'stress' on salt and water balance is largely determined by intrinsic renal factors supported by a series of inter-related neuro-humoral mechanisms which serve to enhance salt and water reabsorption and to maintain arterial pressure. As shown by acute hypovolaemic stress, the hormone response is characterized by increased renin-angiotensin production and associated hyperaldosteronism, which is further augmented by states of Na+ depletion. As well as increasing aldosterone secretion, angiotensin II has a direct renal effect to increase Na+ retention, and may stimulate both thirst and arginine vasopressin secretion...
May 1987: Baillière's Clinical Endocrinology and Metabolism
V A Cameron, E A Espiner, M G Nicholls, D S Skidmore
The effect of rat atrial natriuretic peptide (ANP) on basal hemodynamic and hormonal function and on the response to acute hemorrhage was studied in eight conscious sheep. ANP infusions (3 micrograms/kg BW bolus, followed by 50 ng/kg.min for 70 min) increased plasma immunoreactive ANP levels from less than 12 pmol/liter to steady state levels of 523 +/- 20 pmol/liter, reduced arterial pressure by 14% (P less than 0.002), increased heart rate by 26% (P less than 0.06), and increased plasma norepinephrine levels (P less than 0...
February 1988: Endocrinology
V Cameron, E A Espiner, M G Nicholls, L M Sinclair
When levels of plasma angiotensin converting activity (ACE) were measured in 11 sheep undergoing a 15 ml/kg hemorrhage, levels before hemorrhage (5.7 +/- 0.5 nmol/min/ml) fell significantly at 120 min (3.7 +/- 0.6 nmol/min/ml) and 150 min (3.4 +/- 0.5 nmol/min/ml) after hemorrhage (P less than 0.01). Plasma ACE activity remained constant in ten control sheep studied under the same conditions but not hemorrhaged. The time course of the fall in plasma ACE activity was then studied in an additional four sheep undergoing 15 ml/kg hemorrhage, which reduced mean arterial pressure by 25% at 10 min after hemorrhage...
1987: Circulatory Shock
V A Cameron, E A Espiner, N B Marsh
The central actions of atrial natriuretic peptide (ANP) in rats include inhibition of arginine vasopressin (AVP) release, and less consistently, ACTH suppression and hypotension. To explore any such inhibitory actions on basal and stimulated levels of AVP and ACTH, we have studied the effect of intracerebroventricular (ICV) infusion of ANP on the hemodynamic and hormonal response to acute hemorrhage in conscious sheep. Two groups of 5 sheep received rat ANP(101-126) by ICV infusion (0.5 microgram bolus followed by 0...
December 1990: Neuroendocrinology
C J Charles, E A Espiner, V A Cameron, A M Richards, T G Yandle, E J Sybertz
Whole body clearance of atrial natriuretic factor is due to both receptor uptake and enzymatic degradation initiated by neutral endopeptidase 24.11. The effects of neutral endopeptidase inhibition have been studied in seven sodium-replete sheep using SCH 39370, a specific and potent inhibitor of neutral endopeptidase, in the presence or absence of exogenous hormone [rat ANF-(101-126), 2.4 pmol/kg/min for 2 hours]. SCH 39370 alone (2.5 mg/kg bolus) increased plasma atrial natriuretic factor and plasma cyclic GMP levels, lowered arterial pressure for periods beyond changes in plasma atrial natriuretic factor or cyclic GMP, and suppressed both plasma aldosterone and cortisol levels when compared with vehicle injections...
May 1991: Hypertension
M A Fitzpatrick, M T Rademaker, C M Frampton, E A Espiner, T G Yandle, G A'Court, H Ikram
Results of uncontrolled studies suggest that the duration of action of an ACE inhibitor may be an important determinant of renal impairment when using these agents to treat patients with heart failure. To determine whether there is experimental evidence for this hypothesis, we compared the effects of intermittent (captopril, 25 mg i.v. bolus twice daily) and continuous (captopril. 25 mg bolus, then 50 mg/day by constant infusion) ACE inhibition in an ovine model where heart failure was induced by rapid left ventricular pacing (LVP)...
October 1990: Journal of Cardiovascular Pharmacology
C J Charles, A M Richards, E A Espiner
C-type natriuretic peptide (CNP) and its specific receptor (ANPRB) are richly distributed throughout the brain, especially the anterior pituitary and hypothalamus but not in tissue of nonneural origin. These findings suggest that the actions of CNP, unlike atrial natriuretic factor (ANF), are largely confined to the brain where CNP may participate in the central regulation of hemodynamics and salt and water balance. Therefore, we have studied the hemodynamic, renal, and hormonal effects of continuous intracerebroventricular infusions of CNP (5 micrograms/h for 4 h) in a vehicle-controlled study and compared the responses to those of ANF in normal conscious sheep...
October 1992: Endocrinology
E A Espiner, H Mansfield, K Miles
No abstract text is available yet for this article.
September 14, 1977: New Zealand Medical Journal
P J Dunn, R A Donald, E A Espiner
Twelve acromegalic patients were studied in one or more of three protocols to establish the response of plasma growth hormone (hGH) concentraions to (a) a single oral test dose of bromocriptine, (b) incremental dose therapy from 10 mg/day to 40 mg/day over 4 weeks, and (c) sustained therapy with 20 mg/day over a 3 month period. Ten of the patients studied had previously been treated by yttrium implantation, external pituitary irradiation or surgical hypophysectomy. A high incidence of side effects including postural hypotension, hallucinations and peripheral vasospasm was noted reducing the numbers of patients completing the three protocols...
October 1977: Clinical Endocrinology
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