Cindy M Spruit, Diana I Palme, Tiehai Li, María Ríos Carrasco, Alba Gabarroca García, Igor R Sweet, Maryna Kuryshko, Joshua C L Maliepaard, Karli R Reiding, David Scheibner, Geert-Jan Boons, Elsayed M Abdelwhab, Robert P de Vries
Influenza A viruses (IAVs) can overcome species barriers by adaptation of the receptor-binding site of the hemagglutinin (HA). To initiate infection, HAs bind to glycan receptors with terminal sialic acids, which are either N -acetylneuraminic acid (NeuAc) or N -glycolylneuraminic acid (NeuGc); the latter is mainly found in horses and pigs but not in birds and humans. We investigated the influence of previously identified equine NeuGc-adapting mutations (S128T, I130V, A135E, T189A, and K193R) in avian H7 IAVs in vitro and in vivo ...
March 12, 2024: Journal of Virology