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MR inflammatory bowel

Michael Hunter Lanier, Anup S Shetty, Amber Salter, Geetika Khanna
BACKGROUND: Gadolinium deposition in normal tissues is being increasingly recognized. Children with inflammatory bowel disease (IBD) undergo frequent imaging with contrast-enhanced MR enterography (MRE). PURPOSE: To determine the impact of intravenous (IV) gadolinium in assessment of pediatric IBD by MRE. STUDY TYPE: Retrospective, case series. POPULATION: Radiology information system was searched to identify all children who underwent MRE and endoscopy within 30 days in 2016...
March 5, 2018: Journal of Magnetic Resonance Imaging: JMRI
H Schöllnast
BACKGROUND: During the course of the disease, chronic inflammatory bowel diseases (CIBD) show different activities, which-in addition to morphological changes-significantly influence the choice of therapy. OBJECTIVE: The value of imaging in characterization of the activity of inflammatory changes is evaluated. MATERIALS AND METHODS: In the present review of the current literature, indications, performance, and findings of imaging of inflammatory bowel disease and on the assessment of disease activity are assessed...
March 2, 2018: Der Radiologe
Yan Li, Karsten Beiderwellen, Felix Nensa, Johannes Grüneisen, Gustav Dobos, Ken Herrmann, Thomas Lauenstein, Lale Umutlu, Jost Langhorst
PURPOSE: To evaluate the diagnostic performance of integrated whole-body positron emission tomography (PET)/magnetic resonance (MR) enterography in patients with Crohn's disease (CD). METHODS: Fifty patients with known CD and recurrent symptoms underwent ileocolonoscopy (reference standard) as well as PET/MR enterography. Seven ileocolonic segments were endoscopically analysed using the Simplified Endoscopic Activity Score for Crohn's Disease (SES-CD) and additionally classified into three categories of inflammation (none, mild to moderate and severe ulcerative inflammation)...
February 17, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Xue-Hua Li, Ren Mao, Si-Yun Huang, Can-Hui Sun, Qing-Hua Cao, Zhuang-Nian Fang, Zhong-Wei Zhang, Li Huang, Jin-Jiang Lin, Yu-Jun Chen, Jordi Rimola, Florian Rieder, Min-Hu Chen, Shi-Ting Feng, Zi-Ping Li
Purpose To evaluate the role of magnetization transfer (MT) magnetic resonance (MR) imaging for the characterization of intestinal fibrosis compared with contrast material-enhanced and diffusion-weighted MR imaging and its capability for differentiating fibrotic from inflammatory strictures in humans with Crohn disease (CD) by using surgical histopathologic analysis as the reference standard. Materials and Methods Institutional review board approval and informed consent were obtained for this prospective study...
January 19, 2018: Radiology
Kemal Erol, Kevser Gok, Gizem Cengiz, Gamze Kilic, Erkan Kilic, Salih Ozgocmen
OBJECTIVE: Although the prevalence of peripheral and extra-articular disease in ankylosing spondylitis (AS) has been assessed in many studies, data on non-radiographic axial spondyloarthritis (nr-axSpA) is scanty. The aim of this study was first, to compare radiographic-axSpA/AS (r-axSpA/AS) and nr-axSpA concerning peripheral arthritis and extra-articular manifestations (EAMs), and second, to assess potential differences between patient subgroups with or without EAMs regarding disease burden...
January 16, 2018: Acta Reumatológica Portuguesa
Irma van Die, Richard D Cummings
Infection with parasitic helminths affects humanity and animal welfare. Parasitic helminths have the capacity to modulate host immune responses to promote their survival in infected hosts, often for a long time leading to chronic infections. In contrast to many infectious microbes, however, the helminths are able to induce immune responses that show positive bystander effects such as the protection to several immune disorders, including multiple sclerosis, inflammatory bowel disease, and allergies. They generally promote the generation of a tolerogenic immune microenvironment including the induction of type 2 (Th2) responses and a sub-population of alternatively activated macrophages...
2017: Frontiers in Immunology
Jalal Asadi, Sanjay S Bhandari, Nauman Ahmed
A 25-year-old male with a background of ulcerative colitis presented with a two-week history of central chest pain. His ECG on presentation showed global T wave inversion with a peak troponin I of 165 ng/ml. Clinical diagnosis of myopericarditis/myocarditis was made. Echocardiography and cardiac MR confirmed the diagnosis. On detailed assessment of his medication history, mesalazine was suspected as an aetiological factor, with discontinuation resulting in an improvement in symptoms, inflammatory markers and cardiac enzymes...
November 14, 2017: Echo Research and Practice
Zehour AlSabban, Nicholas Carman, Rahim Moineddin, Ryan T Lo, Sebastian K King, Jacob C Langer, Thomas D Walters, Anne M Griffiths, Peter C Church, Mary-Louise C Greer
BACKGROUND: Pediatric Crohn's disease is associated with perianal disease (PAD). Magnetic resonance enterography (MRE) assesses small bowel involvement in pediatric inflammatory bowel disease (PIBD). Pelvic MRI (P-MRI) is the gold standard for assessing PAD. PURPOSE: To determine if MRE can accurately detect PAD in PIBD, distinguishing perianal fistulae (PAF) from perianal abscesses (PAA), referenced against P-MRI. STUDY TYPE: Retrospective...
November 14, 2017: Journal of Magnetic Resonance Imaging: JMRI
Hee Mang Yoon, Chong Hyun Suh, Jeong Rye Kim, Jin Seong Lee, Ah Young Jung, Kyung Mo Kim, Young Ah Cho
Importance: Magnetic resonance (MR) enterography has the advantage over other techniques of being noninvasive, lacking ionizing radiation, and demonstrating excellent soft-tissue contrast to evaluate pediatric patients with inflammatory bowel disease (IBD). Objective: To evaluate the diagnostic performance of MR enterography for detection of active inflammation in children and adolescents with known or suspected IBD. Data Sources: A search of MEDLINE and EMBASE up to January 2, 2017, was performed to identify studies...
December 1, 2017: JAMA Pediatrics
Rune Wilkens, Rikke H Hagemann-Madsen, David A Peters, Agnete H Nielsen, Charlotte B Nørager, Henning Glerup, Klaus Krogh
Background and Aims: Increased small intestinal wall thickness correlates with both inflammatory activity and fibrosis in Crohn's disease (CD). Assessment of perfusion holds promise as an objective marker distinguishing between the two conditions. Our primary aim was to determine if relative bowel wall perfusion measurements correlate with histopathological scores for inflammation or fibrosis in CD. Methods: Twenty-five patients were investigated prior to elective surgery for small intestinal CD...
August 3, 2017: Journal of Crohn's & Colitis
Johannes Boos, Jieming Fang, Christina M Chingkoe, Michele Perillo, Martin Smith, Vassilios Raptopoulos, Olga R Brook
OBJECTIVE: The purpose of this article is to evaluate the image quality and added value of split-bolus contrast agent injection combining late arterial and portal venous phases compared with single-bolus contrast agent injection late arterial phase CT enterography. MATERIALS AND METHODS: Consecutive patients who underwent CT enterography before and after implementation of a single-bolus CT enterography protocol were included. Attenuation and contrast-to-noise ratio (CNR) were assessed by ROI measurements of the bowel wall and arterial and venous structures...
November 2017: AJR. American Journal of Roentgenology
Maja Hrabak-Paar, Marko Kralik
History A 68-year-old man was admitted to the hospital for work-up because of generalized fatigue, anorexia, chronic diarrhea, and weight loss. Laboratory work-up revealed an erythrocyte sedimentation rate of 58 mm/h (reference range, 3-23 mm/h), a hemoglobin level of 14.1 g/dL (reference range, 13.8-17.5 g/dL), a leukocyte count of 8.1 × 109/L (reference range, [3.4-9.7] × 109/L), a platelet count of 223 × 109/L (reference range, [158-424] × 109/L), an alkaline phosphatase level of 85 U/L (1.42 μkat/L) (normal level, <142 U/L [2...
August 2017: Radiology
Gang Liu, Lei Yu, Jun Fang, Chien-An Andy Hu, Jie Yin, Hengjia Ni, Wenkai Ren, Veeramuthu Duraipandiyan, Shuai Chen, Naif Abdullah Al-Dhabi, Yulong Yin
A strong correlation exists between inflammatory bowel disease (IBD) and oxidative stress involving alterations of several key signaling pathways. It is known that methionine promotes reactive oxygen species (ROS) production; we therefore hypothesize that a methionine restriction diet would reduce ROS production, inflammatory responses, and the course of IBD. We generated a murine colitis model by dextran sodium sulfate (DSS) treatment and tested the effects of the methionine restriction diet. Forty-eight mice were randomly divided into four groups of equal size, which included a control (CON) group, an MR (methionine restriction diet) group, a DSS treated group and an MR-DSS treated group...
July 4, 2017: Oncotarget
Timothy L Tsai, Megan B Marine, Matthew R Wanner, Matthew L Cooper, Steven J Steiner, Fangqian Ouyang, S Gregory Jennings, Boaz Karmazyn
BACKGROUND: There is growing literature on the use of ultrasound (US) for evaluation of Crohn disease in adults, but few studies have been conducted on children. Several studies demonstrated high accuracy of US in the diagnosis of Crohn disease. Using US as the primary screening imaging modality for Crohn disease can reduce health care costs, the need for sedation and ionizing radiation exposure. OBJECTIVE: The aim of our study is to determine if US can be used for screening evaluation of pediatric Crohn disease...
July 2017: Pediatric Radiology
Alberto Signore, Andor W J M Glaudemans, Olivier Gheysens, Chiara Lauri, Onofrio A Catalano
In this review article, we focus on the most recent applications of nuclear medicine techniques (mainly 99mTc/111In white blood cells (WBC) scan, [18F]-FDG-PET/CT, [18F]-FDG-PET/MRI, and 99mTc-IL-2 scintigraphy) in the study of children affected by peripheral bone osteomyelitis, fungal infections, inflammatory bowel diseases, and type 1 diabetes, owing to recent important published evidences of their role in the management of these diseases. For osteomyelitis in children, both bone scintigraphy and [18F]-FDG-PET have a major advantage of assessing the whole body in one imaging session to confirm or exclude multifocal involvement, whereas WBC scan has a limited role...
May 2017: Seminars in Nuclear Medicine
Alessandro Campari, Marcello Napolitano, Giovanna Zuin, Luciano Maestri, Giovanni Di Leo, Francesco Sardanelli
BACKGROUND: Colonic involvement in pediatric inflammatory bowel disease is common. Magnetic resonance (MR) enterography is considered the best imaging modality for pediatric inflammatory bowel disease evaluation. It is unclear whether the lack of a dedicated large bowel preparation prevents a reliable colonic assessment. OBJECTIVE: To determine the diagnostic performance of standard MR enterography in detecting and grading colonic inflammatory activity. MATERIALS AND METHODS: We retrospectively evaluated children who underwent both MR enterography and ileocolonoscopy with biopsies <4 weeks apart...
June 2017: Pediatric Radiology
Sophie Sadigh, Mark Chopra, Michael R Sury, Neil Shah, Øystein E Olsen, Tom A Watson
MR enterography is the accepted imaging reference standard for small bowel assessment in inflammatory bowel disease. There is an increasing cohort of children with inflammatory bowel disease presenting at an early age (<5 years) with severe disease. Younger children present a technical challenge for enterography because of the need for sedation/general anaesthesia to allow image optimisation and the need for oral contrast to allow adequate luminal assessment. Through our experiences, MR enteroclysis under general anaesthesia has proven to be a successful imaging technique for the work-up of these patients...
June 2017: Pediatric Radiology
Ishrat Mansuri, Joel G Fletcher, David H Bruining, Amy B Kolbe, Jeff L Fidler, Sunil Samuel, Jeanne Tung
OBJECTIVE: Pediatric small-bowel (SB) Crohn disease (CD) may be missed if the terminal ileum (TI) appears normal at endoscopy and SB imaging is not performed. We sought to estimate the prevalence and clinical characteristics of pediatric patients with CD and endoscopic skipping of the TI-that is, pediatric patients with active SB or upper gut inflammation and an endoscopically normal TI. MATERIALS AND METHODS: This retrospective study included pediatric patients with CD who underwent both CT enterography (CTE) or MR enterography (MRE) and ileocolonoscopy within a 30-day period between July 2004 and April 2014...
June 2017: AJR. American Journal of Roentgenology
J L Barber, J Maclachlan, K Planche, M Furman, D Crespi, N Bab, I Beal
AIM: To investigate concordance of bowel ultrasound and magnetic resonance enterography (MRE) in identifying active disease in children with inflammatory bowel disease. MATERIALS AND METHODS: The imaging of children with inflammatory bowel disease who had undergone bowel ultrasound and MRE within 30 days were retrospectively reviewed, from January 2009 to November 2015. Ultrasound was without oral contrast medium; MRI was conducted with patients unsedated with oral contrast medium and gadolinium...
July 2017: Clinical Radiology
Annalisa Mantarro, Paola Scalise, Elisa Guidi, Emanuele Neri
Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract, with unpredictable clinical course by phases of relapses alternating with other of quiescence. The etiology is multifactorial and is still not completely known; globally the westernization of lifestyle is causing an increasing incidence of CD, with peak age of 20-30 years. The diagnostic workup begins with the evaluation of the clinical history, physical examination and laboratory tests. However, the clinical assessment is subjected interobserver variability and, occasionally, the symptoms of acute and chronic inflammation may be indistinguishable...
February 28, 2017: World Journal of Radiology
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