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https://www.readbyqxmd.com/read/29454230/the-effects-of-pressure-biofeedback-training-on-infraspinatus-muscle-activity-and-muscle-thickness
#1
Il-Young Yu, Yeon-Ki Choo, Mon-Hwan Kim, Jae-Seop Oh
The aim of this study was to investigate muscle activity in the infraspinatus and posterior deltoid and infraspinatus muscle thickness during a prone external rotation (PER) exercise using pressure biofeedback. Fifteen healthy men participated in this study, performing PER exercise with pressure biofeedback under four conditions (comfortable, 2 mm Hg, 4 mm Hg, and 8 mm Hg). Surface electromyography (EMG) was used to monitor infraspinatus and posterior deltoid muscle activity, and ultrasonography was used to collect infraspinatus muscle thickness data...
January 31, 2018: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29454201/nitrous-oxide-emissions-from-near-zero-water-exchange-brackish-recirculating-aquaculture-systems
#2
Uri Yogev, Adiel Atari, Amit Gross
The development of intensive recirculating aquaculture systems (RAS) with low water exchange has accelerated in recent years as a result of environmental, economic and other concerns. In these systems, fish are commonly grown at high density, 50 to 150kg/m 3 , using high-protein (30%-60%) feeds. Typically, the RAS consists of a solid treatment and a nitrification unit; in more advanced RAS, there is an additional denitrification step. Nitrous oxide (N 2 O), a byproduct during nitrification and denitrification processes, is a potent greenhouse gas that destroys the ozone layer...
February 14, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29454057/pullulan-suppresses-the-denaturation-of-myofibrillar-protein-of-grass-carp-ctenopharyngodon-idella-during-frozen-storage
#3
Longfa Jiang, Shengjun Wu
This study aims to investigate the effect of pullulan on the denaturation of the myofibrillar protein of grass carp (Ctenopharyngodon idella) during frozen storage at -18 °C for 30 days. Pullulan or commercial cryoprotectant (1 g dry weight) were added to 100 g of the myofibrillar protein of grass carp (C. idella), respectively, which was frozenly stored at -18 °C for 30 days, and the changes in the state of unfrozen of water, solubility, Ca 2+ -adenylpyrophosphatase (ATP ase ) activity, and sulfhydryl content of myofibrils were monitored during frozen storage...
February 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29453990/atp-activated-p2x7-receptor-in-the-pathophysiology-of-mood-disorders-and-as-an-emerging-target-for-the-development-of-novel-antidepressant-therapeutics
#4
REVIEW
Linyu Wei, Sharifah A Syed Mortadza, Jing Yan, Libin Zhang, Lu Wang, Yaling Yin, Chaokun Li, Sylvie Chalon, Patrick Emond, Catherine Belzung, Dongliang Li, Chengbiao Lu, Sebastien Roger, Lin-Hua Jiang
Mood disorders are a group of psychiatric conditions that represent leading global disease burdens. Increasing evidence from clinical and preclinical studies supports that innate immune system dysfunction plays an important part in the pathophysiology of mood disorders. P2X7 receptor, belonging to the ligand-gated ion channel P2X subfamily of purinergic P2 receptors for extracellular ATP, is highly expressed in immune cells including microglia in the central nervous system (CNS) and has a vital role in mediating innate immune response...
February 14, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29453635/monitoring-of-erlotinib-in-pancreatic-cancer-patients-during-long-time-administration-and-comparison-to-a-physiologically-based-pharmacokinetic-model
#5
Andrea Gruber, Martin Czejka, Philipp Buchner, Marie Kitzmueller, Nairi Kirchbaumer Baroian, Christian Dittrich, Azra Sahmanovic Hrgovcic
PURPOSE: In this study, a therapeutic drug monitoring (TDM) of erlotinib in pancreatic cancer patients was performed over 50 weeks to reveal possible alterations in erlotinib plasma concentrations. Additionally, a physiologically based pharmacokinetic (PBPK) model was created to assess such variations in silico. METHODS: Patients with advanced pancreatic cancer received a chemotherapeutic combination of 100 mg erlotinib q.d., 500-900 mg capecitabine b.d. and 5 mg/kg bevacizumab q...
February 16, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29453319/leptin-signaling-mediates-obesity-associated-csc-enrichment-and-emt-in-preclinical-tnbc-models
#6
Laura W Bowers, Emily L Rossi, Shannon B McDonell, Steven S Doerstling, Subreen A Khatib, Claire G Lineberger, Jody E Albright, Xiaohu Tang, Linda A deGraffenried, Stephen D Hursting
Obesity is associated with poor prognosis in triple-negative breast cancer (TNBC). Preclinical models of TNBC were used to test the hypothesis that increased leptin signaling drives obesity-associated TNBC development by promoting cancer stem cell (CSC) enrichment and/or epithelial-to-mesenchymal transition (EMT). MMTV-Wnt-1 transgenic mice, which develop spontaneous basal-like, triple-negative mammary tumors, received either a control diet (10% kcal from fat) or a diet-induced obesity regimen (DIO, 60% kcal from fat) for up to 42 weeks (n=15/group)...
February 16, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29453304/protocol-investigating-the-clinical-utility-of-an-objective-measure-of-attention-impulsivity-and-activity-qbtest-for-optimising-medication-management-in-children-and-young-people-with-adhd-qbtest-utility-for-optimising-treatment-in-adhd-quota-a-feasibility
#7
Charlotte L Hall, Marilyn James, Sue Brown, Jennifer L Martin, Nikki Brown, Kim Selby, Julie Clarke, Hena Vijayan, Boliang Guo, Kapil Sayal, Chris Hollis, Madeleine J Groom
INTRODUCTION: Attention-deficit hyperactivity disorder (ADHD) is characterised by symptoms of inattention, hyperactivity and impulsivity. To improve outcomes, the National Institute for Health and Care Excellence ADHD guidelines recommend regular monitoring of symptoms when children commence medication. However, research suggests that routine monitoring rarely happens, and clinicians often rely on subjective information such as reports from parents and teachers to ascertain improvement...
February 15, 2018: BMJ Open
https://www.readbyqxmd.com/read/29453283/chemical-stresses-fail-to-mimic-the-unfolded-protein-response-resulting-from-luminal-load-with-unfolded-polypeptides
#8
Timothy J Bergmann, Ilaria Fregno, Fiorenza Fumagalli, Andrea Rinaldi, Francesco Bertoni, Paul J Boersema, Paola Picotti, Maurizio Molinari
The stress sensors ATF6, IRE1 and PERK monitor deviations from homeostatic conditions in the endoplasmic reticulum (ER), a protein biogenesis compartment of eukaryotic cells. Their activation elicits unfolded protein responses (UPR) to re-establish proteostasis. UPR have been extensively investigated in cells exposed to chemicals that activate ER stress sensors by perturbing calcium, N-glycans or redox homeostasis. Cell responses to variations in luminal load with unfolded proteins are, in contrast, poorly characterized...
February 16, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29453178/seasonal-dynamics-of-tetracycline-resistance-gene-transport-in-the-sumas-river-agricultural-watershed-of-british-columbia-canada
#9
Patricia L Keen, Charles W Knapp, Kenneth J Hall, David W Graham
Environmental transport of contaminants that can influence the development of antibiotic resistance in bacteria is an important concern in the management of ecological and human health risks. Agricultural regions are locales where practices linked to food crop and livestock production can introduce contaminants that could alter the selective pressures for the development of antibiotic resistance in microbiota. This is important in regions where the use of animal manure or municipal biosolids as waste and/or fertilizer could influence selection for antibiotic resistance in pathogenic bacterial species...
February 13, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29453069/combined-effect-of-copper-and-hydrodynamic-conditions-on-myriophyllum-alterniflorum-biomarkers
#10
Maha Krayem, Véronique Deluchat, Philippe Hourdin, Patrice Fondanèche, Florence Lecavelier Des Etangs, Véronique Kazpard, Christian Moesch, Pascal Labrousse
The aim of this study is to determine the combined effect of copper and hydrodynamic conditions on the response of certain biomarkers of an aquatic macrophyte, namely Myriophyllum alterniflorum. Watermilfoil biomarkers are monitored in a synthetic medium enriched or not with copper (100 μg.L -1 ) for 21 days in aquarium systems (150 L), under three hydrodynamic conditions: laminar, turbulent, and calm. The studied biomarkers are: respiratory and photosynthetic activities; concentrations of chlorophyll a, b and carotenoids; osmotic potential; hydrogen peroxide content; and growth...
February 9, 2018: Chemosphere
https://www.readbyqxmd.com/read/29453008/forensic-image-analysis-cctv-distortion-and-artefacts
#11
REVIEW
Dilan Seckiner, Xanthé Mallett, Claude Roux, Didier Meuwly, Philip Maynard
As a result of the worldwide deployment of surveillance cameras, authorities have gained a powerful tool that captures footage of activities of people in public areas. Surveillance cameras allow continuous monitoring of the area and allow footage to be obtained for later use, if a criminal or other act of interest occurs. Following this, a forensic practitioner, or expert witness can be required to analyse the footage of the Person of Interest. The examination ultimately aims at evaluating the strength of evidence at source and activity levels...
February 6, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29452619/monitoring-response-to-therapy
#12
REVIEW
Mike M Sathekge, Alfred O Ankrah, Ismaheel Lawal, Mariza Vorster
Monitoring response to treatment is a key element in the management of infectious diseases, yet controversies still persist on reliable biomarkers for noninvasive response evaluation. Considering the limitations of invasiveness of most diagnostic procedures and the issue of expression heterogeneity of pathology, molecular imaging is better able to assay in vivo biologic processes noninvasively and quantitatively. The usefulness of 18 F-FDG-PET/CT in assessing treatment response in infectious diseases is more promising than for conventional imaging...
March 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29452616/tuberculosis
#13
REVIEW
Alfred O Ankrah, Andor W J M Glaudemans, Alex Maes, Christophe Van de Wiele, Rudi A J O Dierckx, Mariza Vorster, Mike M Sathekge
Tuberculosis (TB) is currently the world's leading cause of infectious mortality. Imaging plays an important role in the management of this disease. The complex immune response of the human body to Mycobacterium tuberculosis results in a wide array of clinical manifestations, making clinical and radiological diagnosis challenging. 18 F-FDG-PET/CT is very sensitive in the early detection of TB in most parts of the body; however, the lack of specificity is a major limitation. 18 F-FDG-PET/CT images the whole body and provides a pre-therapeutic metabolic map of the infection, enabling clinicians to accurately assess the burden of disease...
March 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29452521/clinical-trial-quality-from-supervision-to-collaboration-and-beyond
#14
Ann Meeker-O'Connell, Coleen Glessner
Over the past decade, clinical trial quality has evolved from an after-the-fact, reactive activity to one focused on the important work of evidence generation from well-designed trials. This article explores the role the Clinical Trials Transformation Initiative has played in advancing quality as a core element of clinical trial design, through project work that initially focused on monitoring but evolved into a holistic, prospective, and comprehensive quality by design approach to clinical trial design and conduct...
February 2018: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/29452212/exploring-in-vivo-metabolism-and-excretion-of-qo-58l-using-ultra-high-performance-liquid-chromatography-coupled-with-tandem-mass-spectrometry
#15
Jiaqi Zhang, Qingzhong Jia, Jinlong Qi, Hailin Zhang, Yaru Wu, Xiaowei Shi
QO-58 lysine (QO-58L) as a new potassium channel opener, reported to have a potential activity to cure neuropathic pain. The aim of this research is to develop and validate a high-performance liquid chromatography with tandem spectrometry (LC-MS/MS) method for the quantification of QO-58L in rat urine, feces and bile. In addition, analyze and identify the metabolites in urine and bile. The assay for this compound in samples detected with multiple reaction monitoring mode (MRM), and take nimodipine as internal standards (IS)...
February 13, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29451742/real-time-monitoring-prefrontal-activities-during-online-video-game-playing-by-functional-near-infrared-spectroscopy
#16
Yue Li, Lei Zhang, Kehong Long, Hui Gong, Hao Lei
A growing body of literature has suggested that video game playing can induce functional and structural plasticity of the brain. The underlying mechanisms, however, remain poorly understood. In this study, functional near-infrared spectroscopy (fNIRS) was used to record prefrontal activities in 24 experienced game players when they played a massively multiplayer online battle arena (MOBA) video game, League of Legends (LOL), under naturalistic conditions. It was observed that game onset was associated with significant activations in the ventrolateral prefrontal cortex (VLPFC) and concomitant deactivations in the dorsolateral prefrontal cortex (DLPFC) and frontal pole area (FPA)...
February 16, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29451684/intracellular-pharmacokinetics-of-gemcitabine-its-deaminated-metabolite-2-2-difluorodeoxyuridine-and-their-nucleotides
#17
Ellen J B Derissen, Alwin D R Huitema, Hilde Rosing, Jan H M Schellens, Jos H Beijnen
AIMS: Gemcitabine (2',2'-difluoro-2'-deoxycytidine, dFdC) is a prodrug that has to be phosphorylated within the tumour cell to become active. Intracellularly formed gemcitabine diphosphate (dFdCDP) and triphosphate (dFdCTP) are held responsible for the antineoplastic effects. However, a major part of gemcitabine is converted into 2',2'-difluoro-2'-deoxyuridine (dFdU) by deamination. In the cell, dFdU can also be phosphorylated to its monophosphate (dFdUMP), diphosphate (dFdUDP) and triphosphate (dFdUTP)...
February 16, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29451663/the-analysis-on-the-expression-of-gasotransmitters-in-early-trauma-patients
#18
Zhiyong Wang, Mignxing Fang, Jianying Guo, Yong Yang, Fengjun Tian
OBJECTIVE: Nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) were endogenously-generated molecules gas. They owned important biological activity and participated in many pathophysiological processes. This study aimed to examine the levels of three gasotransmitters in the early phase of trauma patients. METHOD: Blood samples were collected from 60 trauma patients and ten healthy volunteers. Concentration of serum iNOS and HO-1 were analyzed by enzyme linked immunosorbent assay and plasma H2S was determined by colorimetric method...
November 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29451368/public-health-response-to-an-imported-case-of-canine-melioidosis
#19
C W Ryan, K Bishop, D D Blaney, S J Britton, F Cantone, C Egan, M G Elrod, C W Frye, A M Maxted, G Perkins
Melioidosis in humans presents variably as fulminant sepsis, pneumonia, skin infection and solid organ abscesses. It is caused by Burkholderia pseudomallei, which in the United States is classified as a select agent, with "potential to pose a severe threat to both human and animal health, to plant health or to animal and plant products" (Federal Select Agent Program, http://www.selectagents.gov/, accessed 22 September 2016). Burkholderia pseudomallei is found in soil and surface water in the tropics, especially South-East Asia and northern Australia, where melioidosis is endemic...
February 16, 2018: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29451114/molecular-tools-to-study-preharvest-food-safety-challenges
#20
Deepak Kumar, Siddhartha Thakur
Preharvest food safety research and activities have advanced over time with the recognition of the importance and complicated nature of the preharvest phase of food production. In developed nations, implementation of preharvest food safety procedures along with strict monitoring and containment at various postharvest stages such as slaughter, processing, storage, and distribution have remarkably reduced the burden of foodborne pathogens in humans. Early detection and adequate surveillance of pathogens at the preharvest stage is of the utmost importance to ensure a safe meat supply...
February 2018: Microbiology Spectrum
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