keyword
MENU ▼
Read by QxMD icon Read
search

Activity monitor

keyword
https://www.readbyqxmd.com/read/29050366/the-resistance-mechanisms-and-treatment-strategies-for-egfr-mutant-advanced-non-small-cell-lung-cancer
#1
REVIEW
Wen-Zhao Zhong, Qing Zhou, Yi-Long Wu
Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKI) have been established as the standard therapy for EGFR-sensitizing mutant advanced non-small-cell lung cancer (NSCLC). However, patients ultimately develop resistance to these drugs. There are several mechanisms of both primary and secondary resistance to EGFR-TKIs. The primary resistance mechanisms include point mutations in exon 18, deletions or insertions in exon 19, insertions, duplications and point mutations in exon 20 and point mutation in exon 21 of EGFR gene...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050232/progressive-modulation-of-the-human-olfactory-bulb-transcriptome-during-alzheimer%C3%A2-s-disease-evolution-novel-insights-into-the-olfactory-signaling-across-proteinopathies
#2
Mercedes Lachen-Montes, María Victoria Zelaya, Víctor Segura, Joaquín Fernández-Irigoyen, Enrique Santamaría
Alzheimer´s disease (AD) is characterized by progressive dementia, initially presenting olfactory dysfunction. Despite the olfactory bulb (OB) is the first central structure of the olfactory pathway, we lack a complete molecular characterization of the transcriptional events that occurs in this olfactory area during AD progression. To address this gap in knowledge, we have assessed the genome-wide expression in postmortem OBs from subjects with varying degree of AD pathology. A stage-dependent deregulation of specific pathways was observed, revealing transmembrane transport, and neuroinflammation as part of the functional modules that are disrupted across AD grading...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050023/monitoring-of-root-caries-lesions
#3
Iain A Pretty
The early detection of root caries is essential for the implementation of appropriate preventive therapeutic regimes. Subsequent monitoring of lesions is required to determine the outcomes of such therapies. While much research activity has been seen in the detection and monitoring of enamel caries, this has not been seen in root caries - despite the possibilities for shorter clinical trials due to the more rapid remineralization and arrest of such lesions. The main stay of both clinical practice and research has been the use of visual tactile criteria including, hardness, texture, the presence or absence of cavitation, and color...
2017: Monographs in Oral Science
https://www.readbyqxmd.com/read/29049964/the-bit-doesn-t-fit-evaluation-of-a-commercial-activity-tracker-at-slower-walking-speeds
#4
Christopher K Wong, Helena M Mentis, Ravi Kuber
Accelerometer-based commercial activity trackers are a low-cost and convenient method for monitoring and assessing health measures such as gait. However, the accuracy of these activity trackers in slow walking conditions on a minute-by-minute basis is largely unknown. In this study, the accuracy of a hip-worn commercial activity tracker (FitBit Ultra) was examined through step counts. Accuracy was evaluated through four minute trials of treadmill walking at speeds representative of older adults (0.9, 1.1, and 1...
October 9, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29049961/smartphone-app-based-portable-sensor-for-the-detection-of-fluoro-surfactant-pfoa
#5
Cheng Fang, Xian Zhang, Zhaomin Dong, Liang Wang, Mallavarapu Megharaj, Ravi Naidu
We developed a smartphone app-based monitoring tool for the detection of anionic surfactants (AS), including perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS). Akin to the methylene blue active substances (MBAS), liquid-phase extraction (LPE) is employed to extract the hydrophobic ion-pair of dye (ethyl violet)-AS to an organic phase (ethyl acetate). The colour (RGB) of the organic phase is read using a smartphone camera with the help of a reading kit. The value of RGB is carefully corrected and linked to the concentration of ASs with a standard deviation of <10% in the 10-1000 ppb (part per billion) range...
October 10, 2017: Chemosphere
https://www.readbyqxmd.com/read/29049902/emotion-dysregulation-moderates-the-effect-of-cognitive-behavior-therapy-with-prolonged-exposure-for-co-occurring-ptsd-and-substance-use-disorders
#6
Denise A Hien, Teresa Lopez-Castro, Santiago Papini, Bernard Gorman, Lesia M Ruglass
A goal of clinical trials is to identify unique baseline characteristics that can inform treatment planning. One such target is emotion dysregulation (ED), which contributes to the maintenance of co-occurring posttraumatic stress disorder (PTSD) and substance use disorder (SUD) and may be a potential moderator of treatment response. We examined the moderating impact of ED severity on treatment outcomes in an urban, socioeconomically disadvantaged, and racially/ethnically diverse sample with complex trauma and severe SUDs...
October 16, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/29049835/the-photopic-negative-response-an-objective-measure-of-retinal-ganglion-cell-function-in-patients-with-leber-s-hereditary-optic-neuropathy
#7
Rustum Karanjia, Adriana Berezovsky, Paula Yuri Sacai, Nivea Nunes Cavascan, Henry Yuheng Liu, Samir Nazarali, Milton Nunes Moraes-Filho, Kirsten Anderson, Jeffrey Show Tran, Sung EunSong Watanabe, Milton Nunes Moraes, Federico Sadun, Anna Maria DeNegri, Piero Barboni, Carolina do Val Ferreira Ramos, Chiara La Morgia, Valerio Carelli, Rubens Belfort, Stuart Glenn Coupland, Solange Rios Salomao, Alfredo A Sadun
Purpose: The photopic negative response (PhNR) is a slow negative component of a flash photopic full-field ERG that has been shown to be specific for retinal ganglion cell (RGC) activity. Direct evaluation of RGC function is desirable in patients with Leber's hereditary optic neuropathy (LHON) in which the loss of central acuity can make it difficult to monitor patients with standard metrics. The purpose of this study was to evaluate the use of PhNR as an objective noninvasive clinical metric in LHON...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29049770/accuracy-of-heart-rate-monitoring-by-some-wrist-worn-activity-trackers
#8
Lisa Cadmus-Bertram, Ronald Gangnon, Emily J Wirkus, Keith M Thraen-Borowski, Jessica Gorzelitz-Liebhauser
No abstract text is available yet for this article.
October 17, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29049769/accuracy-of-heart-rate-monitoring-by-some-wrist-worn-activity-trackers
#9
Jasmine Singh, Dean F Sittig
No abstract text is available yet for this article.
October 17, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29049372/therapeutic-effect-of-imiquimod-on-dextran-sulfate-sodium-induced-ulcerative-colitis-in-mice
#10
Lu Chen, Zhongyin Zhou, Yan Yang, Na Chen, Hongyu Xiang
BACKGROUND: Imiquimod is a Toll-like receptor-7 agonist that regulates immunity and can be used as an immune adjuvant. Ulcerative colitis has a close correlation with immune disorder. AIM: To investigate the therapeutic effect of imiquimod on dextran sulfate sodium (DSS)-induced colitis and explore the underlying mechanisms. METHODS: C57BL/6J C57 mice received 3% DSS for 7 days to induce ulcerative colitis. Groups of mice were intraperitoneally injected with dexamethasone (DXM, 1...
2017: PloS One
https://www.readbyqxmd.com/read/29049070/noninfectious-fever-in-the-near-term-pregnant-rat-induces-fetal-brain-inflammation-a-model-for-the-consequences-of-epidural-associated-maternal-fever
#11
Scott Segal, Carlo Pancaro, Iwona Bonney, James E Marchand
BACKGROUND: Women laboring with epidural analgesia experience fever much more frequently than do women who chose other forms of analgesia, and maternal intrapartum fever is associated with numerous adverse consequences, including brain injury in the fetus. We developed a model of noninfectious inflammatory fever in the near-term pregnant rat to simulate the pathophysiology of epidural-associated fever and hypothesized that it would produce fetal brain inflammation. METHODS: Twenty-four pregnant Sprague-Dawley rats were studied at 20 days gestation (term: 22 days)...
October 17, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29048879/near-infrared-fluorescent-probe-with-remarkable-large-stokes-shift-and-favorable-water-solubility-for-real-time-tracking-leucine-aminopeptidase-in-living-cells-and-in-vivo
#12
Wenda Zhang, Feiyan Liu, Chao Zhang, Jian-Guang Luo, Jun Luo, Wenying Yu, Lingyi Kong
Leucine aminopeptidase (LAP) is a kind of proteolytic enzymes and associated closely with pathogenesis of cancer and liver injury. Accurate detection of LAP activity with high sensitivity and selectivity is imperative to detect its distribution and dynamic changes for understanding LAP's function and early diagnosing the disease states. However, fluorescent detection of LAP in living systems is challenging. To data, rarely fluorescent probes have been reported for imaging LAP in vivo. In this study, a novel probe (TMN-Leu) was developed by conjugating a near-infrared dicyanoisophorone derivative fluorophore with LAP activatable L-leucine amide moiety for the first time...
October 19, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29048755/nifedipine-prevents-apoptosis-of-alcohol-exposed-first-trimester-trophoblast-cells
#13
Alan D Bolnick, Jay M Bolnick, Hamid-Reza Kohan-Ghadr, Brian A Kilburn, Michael Hertz, Jing Dai, Sascha Drewlo, D Randall Armant
BACKGROUND: Maternal alcohol abuse leading to fetal alcohol spectrum disorder (FASD) includes fetal growth restriction (FGR). Ethanol induces apoptosis of human placental trophoblast cells, possibly disrupting placentation and contributing to FGR in FASD. Ethanol facilitates apoptosis in several embryonic tissues, including human trophoblasts, by raising intracellular Ca(2+) . We previously found that acute ethanol exposure increases trophoblast apoptosis due to signaling from both intracellular and extracellular Ca(2+) ...
October 19, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29048567/green-fruited-solanum-habrochaites-lacks-fruit-specific-carotenogenesis-due-to-metabolic-and-structural-blocks
#14
Himabindu Vasuki Kilambi, Kalyani Manda, Avanish Rai, Chaitanya Charakana, Jayram Bagri, Rameshwar Sharma, Yellamaraju Sreelakshmi, Christine Raines
Members of the tomato clade exhibit a wide diversity in fruit color, but the mechanisms governing inter-species diversity of coloration are largely unknown. The carotenoid profiles, carotenogenic gene expression and proteome profiles of green-fruited Solanum habrochaites (SH), orange-fruited S. galapagense, and red-fruited S. pimpinellifolium were compared with cultivated tomato [S. lycopersicum cv. Ailsa Craig (SL)] to decipher the molecular basis of coloration diversity. Green-fruited SH, though it showed normal expression of chromoplast-specific phytoene synthase1 and lycopene β-cyclase genes akin to orange/red-fruited species, failed to accumulate lycopene and β-carotene...
October 13, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29048450/aerobiological-monitoring-and-mapping-of-ambrosia-plants-in-the-province-of-parma-northern-italy-southern-po-valley-a-useful-tool-for-targeted-preventive-measures
#15
R Albertini, M Ugolotti, L Ghillani, M Adorni, P Vitali, C Signorelli, C Pasquarella
BACKGROUND: Ambrosia is an annual anemophilous weed producing allergenic pollen affecting public health in European countries. In Italy, the most infested region is Lombardy where, in some areas, it is the major cause of hay fever. In the Parma district, until 2007, Ambrosia seemed to be very rare, despite an observed increase of Seasonal Pollen Index (SPI), of pollen peak value and of asthma among ragweed sensitized patients. The aims of this study were to calculate ragweed pollen season and trends from 1996 to 2015, to assess the relationships between pollen season characteristics and selected meteorological data, to map plants in the territory and to evaluate the presence of beetle Ophraella communa (Ophraella), known as an eater of Ambrosia leaves...
November 2017: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/29048449/emergency-medical-service-information-system-the-ares-118-experience
#16
D A Ientile, M A Cardinale, S Cataldi, M Parafati, A Pasquarella, N Trani, M P Corradi
BACKGROUND: In this paper we describe ARES 118, the prehospital Emergency Medical Service of the Region Lazio, Italy, focusing on its data system used to populate a data warehouse and to create ad hoc reports. ARES 118 is a regional public mono-specialized health company, established in 2004, that manages the emergency care throughout the Region Lazio. METHODS: Being a peculiar company in its kind, and being the first experience of this kind in Italy, ARES 118 has begun to equip itself, in an autonomous way, with a corporate information system, starting from what already existed as data collection from the individual provincial operating Centers and then by activating a unique information system at a regional and company level by deploying a data warehouse...
November 2017: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/29048447/strategies-for-disease-prevention-and-health-promotion-in-urban-areas-the-erice-50-charter
#17
D D'Alessandro, S Arletti, A Azara, M Buffoli, L Capasso, A Cappuccitti, A Casuccio, A Cecchini, G Costa, A M De Martino, M Dettori, E Di Rosa, G M Fara, M Ferrante, G Giammanco, A Lauria, G Melis, U Moscato, I Oberti, C Patrizio, M G Petronio, A Rebecchi, V Romano Spica, G Settimo, C Signorelli, S Capolongo
The Erice 50 Charter titled "Strategies for Diseases Prevention and Health Promotion in Urban Areas" was unanimously approved at the conclusion of the 50th Residential Course "Urban Health. Instruments for promoting health and for assessing hygienic and sanitary conditions in urban areas", held from 29th March to 2nd April 2017 in Erice, at the "Ettore Majorana" Foundation and Centre for Scientific Culture and promoted by the International School of Epidemiology and Preventive Medicine "G. D'Alessandro" and the Study Group "Building Hygiene" of the Italian Society of Hygiene, Preventive Medicine and Public Health (SItI)...
November 2017: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/29047916/optical-mapping-of-prefrontal-activity-in-pathological-gamblers
#18
Xiaohong Lin, Shiyang Xu, Hada Fong-Ha Ieong, Zhen Yuan
Functional near-infrared spectroscopy (fNIRS) has emerged as a highly promising brain mapping technique that enables continuously and noninvasively monitoring the hemodynamic responses in the human brain. In this study, fNIRS was utilized to identify the different brain activation patterns between pathological gamblers (PGs) and healthy controls (HCs). Specifically, we examined the hemodynamic changes in the prefrontal cortex using fNIRS recordings during the completion of executive function and decision-making tasks for both PGs and HCs...
July 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047413/itactic-implementing-treatment-algorithms-for-the-correction-of-trauma-induced-coagulopathy-study-protocol-for-a-multicentre-randomised-controlled-trial
#19
Kjersti Baksaas-Aasen, Lewis Gall, Simon Eaglestone, Claire Rourke, Nicole P Juffermans, J Carel Goslings, Paal Aksel Naess, Susan van Dieren, Sisse Rye Ostrowski, Jakob Stensballe, Marc Maegele, Simon J Stanworth, Christine Gaarder, Karim Brohi, Per I Johansson
BACKGROUND: Traumatic injury is the fourth leading cause of death globally. Half of all trauma deaths are due to bleeding and most of these will occur within 6 h of injury. Haemorrhagic shock following injury has been shown to induce a clotting dysfunction within minutes, and this early trauma-induced coagulopathy (TIC) may exacerbate bleeding and is associated with higher mortality and morbidity. In spite of improved resuscitation strategies over the last decade, current transfusion therapy still fails to correct TIC during ongoing haemorrhage and evidence for the optimal management of bleeding trauma patients is lacking...
October 18, 2017: Trials
https://www.readbyqxmd.com/read/29047376/women-s-education-level-amplifies-the-effects-of-a-livelihoods-based-intervention-on-household-wealth-child-diet-and-child-growth-in-rural-nepal
#20
Laurie C Miller, Neena Joshi, Mahendra Lohani, Beatrice Rogers, Shubh Mahato, Shibani Ghosh, Patrick Webb
BACKGROUND: Many organizations seek to alleviate poverty in the developing world, often focusing their interventions on women. The role, status, and education of women are fundamentally important facets of development. Thus, understanding the interaction of women's educational level and the response to interventions is important. Therefore, we examined the impact of educational level of household adults on responses to a livestock-based community intervention. METHODS: Six pair-matched communities in 3 districts of Nepal (Chitwan/Nawalparasi/Nuwakot), were randomly assigned to receive community development activities via women's self-help groups at baseline or 1 year later...
October 18, 2017: International Journal for Equity in Health
keyword
keyword
10188
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"