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https://www.readbyqxmd.com/read/29908504/meris-observations-of-phytoplankton-phenology-in-the-baltic-sea
#1
Daoxi Zhang, Samantha Lavender, Jan-Peter Muller, David Walton, Xi Zou, Fang Shi
The historical data from the MEdium Resolution Imaging Spectrometer (MERIS) is an invaluable archive for studying global waters from inland lakes to open oceans. Although the MERIS sensor ceased to operate in April 2012, the data capacities are now re-established through the recently launched Sentinel-3 Ocean and Land Colour Instrument (OLCI). The development of a consistent time series for investigating phytoplankton phenology features is crucial if the potential of MERIS and OLCI data is to be fully exploited for inland water monitoring...
June 13, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29908471/searching-for-synergistic-calcium-antagonists-and-novel-therapeutic-regimens-for-coronary-heart-disease-therapy-from-a-traditional-chinese-medicine-suxiao-jiuxin-pill
#2
Wei Lei, Jianan Ni, Xueting Xia, Min Jiang, Gang Bai
Coronary heart disease is a vital cause of morbidity and mortality worldwide, and calcium channel blockers (CCBs) are important drugs that can be used to treat cardiovascular diseases. Suxiao Jiuxin Pill (SX), a traditional Chinese medicine, is widely used as an emergency drug for coronary heart disease therapy. However, understanding its potential mechanism in intracellular calcium concentration ([Ca2+ ]i ) modulation remains a challenge. To identify the active pharmacological ingredients (APIs) and reveal a novel combination therapy for ameliorating cardiovascular diseases, the ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF MS) combined with a dual-luciferase reporter [Ca2+ ]i assay system was applied...
June 8, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29908257/rutin-attenuates-neurobehavioral-deficits-oxidative-stress-neuro-inflammation-and-apoptosis-in-fluoride-treated-rats
#3
Kpobari W Nkpaa, Godspower I Onyeso
Studies have shown that high exposure to fluoride (NaF) induces neurotoxicity. Rutin (RUT), a citrus flavonoid, has been reported to have antioxidant, anti-inflammatory and anti-apoptotic properties. The aim of this study was to investigate the neuroprotective mechanism(s) of RUT on NaF - induced neurotoxicity. Rats were exposed to NaF alone in drinking water at 15 mg/L alone ad libitum or orally co-treated by gavage with RUT at 50 and 100 mg/kg body weight for 31 consecutive days. A video-tracking software was used to monitor the motor and locomotive behavior during a 5 - min trial time in a novel environment...
June 13, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29907969/physiological-and-behavioural-responses-of-grazing-dairy-cows-to-an-acute-metabolic-challenge
#4
Esther Müller, Andreas Münger, Roi Mandel, Lukas Eggerschwiler, Ann-Catherine Schwinn, Josef J Gross, Rupert M Bruckmaier, H Dieter Hess, Frigga Dohme-Meier
Due to seasonal changes in the quality and quantity of herbage, the nutrient supply to grazing dairy cows is not always sufficient, which may increase their metabolic load. To investigate the temporal pattern of behavioural changes in relation to concomitant metabolic alterations, we subjected 15 multiparous early lactating Holstein dairy cows (24 (SD 7.4) days in milk) to a short-term metabolic challenge, which we provoked by abruptly withdrawing concentrate for 1 week. Cows grazed full-time and were supplemented with concentrate in experimental week (EW) 1 and EW 3, whereas concentrate was withdrawn in EW 2...
June 15, 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29907481/diversity-of-rotavirus-strains-circulating-in-children-under-five-years-of-age-who-presented-with-acute-gastroenteritis-before-and-after-rotavirus-vaccine-introduction-university-teaching-hospital-lusaka-zambia-2008-2015
#5
J C Simwaka, Evans M Mpabalwani, Mapaseka Seheri, Ina Peenze, Mwaka Monze, Belem Matapo, Umesh D Parashar, Jacob Mufunda, Jeffrey M Mphahlele, Jacqueline E Tate, Jason M Mwenda
BACKGROUND: Following the introduction of rotavirus vaccine into the routine immunization schedule, the burden of rotavirus disease has significantly reduced in Zambia. Although rotavirus vaccines appear to confer good cross-protection against both vaccine and non-vaccine strains, concerns about strain replacement following vaccine implementation remain. We describe the diversity of the circulating rotavirus strains before and after the Rotarix® vaccine was introduced in Lusaka from January 2012...
June 12, 2018: Vaccine
https://www.readbyqxmd.com/read/29907134/clinical-outcome-and-physical-activity-measured-with-stepwatch-3%C3%A2-activity-monitor-after-minimally-invasive-total-hip-arthroplasty
#6
Steffen Höll, Andreas Blum, Georg Gosheger, Ralf Dieckmann, Corinna Winter, Dieter Rosenbaum
BACKGROUND: Subjective data and physical examinations of patients after total hip arthroplasty are used to assess the outcome. But regarding the physical activity, no objective data can be delivered by existing scores. The level of activity can be measured objectively by counting gait cycles. The aim of this study was to measure activity levels of patients before and after total hip arthroplasty (THA). METHODS: Forty-six patients were included in this prospective study...
June 15, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29906769/a-novel-quantitative-electrochemical-method-to-monitor-dna-double-strand-breaks-caused-by-a-dna-cleavage-agent-at-a-dna-sensor
#7
Anna Banasiak, John Cassidy, John Colleran
To date, DNA cleavage, caused by cleavage agents, has been monitored mainly by gel and capillary electrophoresis. However, these techniques are time-consuming, non-quantitative and require gel stains. In this work, a novel, simple and, importantly, a quantitative method for monitoring the DNA nuclease activity of potential anti-cancer drugs, at a DNA electrochemical sensor, is presented. The DNA sensors were prepared using thiol-modified oligonucleotides that self-assembled to create a DNA monolayer at gold electrode surfaces...
June 1, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29906757/transport-of-oxaliplatin-species-in-water-saturated-natural-soil
#8
Natalia Goykhman, Ishai Dror, Brian Berkowitz
This study reports the transport characteristics of the organometallic anticancer compound oxaliplatin and its derivatives in natural soil-water environments. Although pharmaceuticals and their derivatives have for many years been detected in water resources, and linked to toxicological impacts on ecological systems, their transport in soil and groundwater is not fully understood. Specifically, studies that describe transport of organometallic pharmaceuticals in porous media are rare, and the transport characteristics of platinum complexes have received little attention...
June 5, 2018: Chemosphere
https://www.readbyqxmd.com/read/29906569/salival-%C3%AE-iduronidase-activity-as-a-potential-new-biomarker-for-the-diagnosis-and-monitoring-the-effect-of-therapy-in-mucopolysaccharidosis-i
#9
Jaap van Doorn, Brigitte T A van den Broek, Ans J Geboers, Gé-Ann Kuiper, J J Boelens, Peter M van Hasselt
Although disease progression in Mucopolysaccharidosis I (MPS-1) can be attenuated by hematopoietic cell transplantation (HCT), it is increasingly recognized that residual disease is substantial. Biomarkers that would allow us to evaluate the efficacy of HCT (and upcoming new therapies) in non-hematological tissues are needed. Current biomarkers, including the iduronidase (IDUA) activity in leukocytes, are not suitable for this purpose as they are assessed in tissues of hematological origin and may not reflect enzyme availability in non-hematologic tissues...
June 12, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29906115/x-ray-emission-spectroscopy-as-an-in-situ-diagnostic-tool-for-x-ray-crystallography-of-metalloproteins-using-an-x-ray-free-electron-laser
#10
Thomas Fransson, Ruchira Chatterjee, Franklin D Fuller, Sheraz Gul, Clemens Weninger, Dimosthenis Sokaras, Thomas Kroll, Roberto Alonso Mori, Uwe Bergmann, Jan Kern, Vittal K Yachandra, Junko Yano
Serial femtosecond crystallography (SFX) using the ultra-short X-ray pulses from a X-ray free-electron laser (XFEL) provides a new way of collecting structural data at room temperature, which also allows for following the reaction in real time after initiating the reaction with a trigger. XFEL experiments are conducted in a shot-by-shot mode as the sample is destroyed and replenished after each X-ray pulse, and therefore monitoring and controlling the data quality by using in situ diagnostic tools is especially important...
June 15, 2018: Biochemistry
https://www.readbyqxmd.com/read/29906094/capacitive-model-for-coulometric-readout-of-ion-selective-electrodes
#11
Zdenka Jarolimova, Tingting Han, Ulriika Mattinen, Johan Bobacka, Eric Bakker
We present here a capacitive model for the coulometric signal transduction readout of solid-contact ion-selective membrane electrodes (SC-ISE) with a conducting polymer (CP) as an intermediate layer for the detection of anions. The capacitive model correlates well with experimental data obtained for chloride-selective SC-ISE utilizing poly(3,4-ethylenedioxythiophene) (PEDOT) doped with chloride as the ion-to-electron transducer. Additionally, Prussian blue is used as a simple sodium capacitor to further demonstrate the role of the transduction layer...
June 15, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29905972/feeling-the-force-how-pollen-tubes-deal-with-obstacles
#12
Jan T Burri, Hannes Vogler, Nino F Läubli, Chengzhi Hu, Ueli Grossniklaus, Bradley J Nelson
Physical forces are involved in the regulation of plant development and morphogenesis by translating mechanical stress into the modification of physiological processes, which, in turn, can affect cellular growth. Pollen tubes respond rapidly to external stimuli and provide an ideal system to study the effect of mechanical cues at the single-cell level. Here, pollen tubes were exposed to mechanical stress while monitoring the reconfiguration of their growth and recording the generated forces in real-time. We combined a lab-on-a-chip device with a microelectromechanical systems (MEMS)-based capacitive force sensor to mimic and quantify the forces that are involved in pollen tube navigation upon confronting mechanical obstacles...
June 15, 2018: New Phytologist
https://www.readbyqxmd.com/read/29905784/blind-esophageal-brushing-offers-a-safe-and-accurate-method-to-monitor-inflammation-in-children-and-young-adults-with-eosinophilic-esophagitis
#13
Y Smadi, C Deb, J Bornstein, S Safder, K Horvath, D Mehta
Patients with eosinophilic esophagitis (EoE) require frequent evaluation of mucosal inflammation via endoscopy. Instead of endoscopy, mucosal evaluation in adults with esophageal cancer and candidiasis is achieved using a cytology brush inserted through a nasogastric tube (NGT). We conducted a prospective cross-sectional study in children and young adults scheduled for routine esophagogastroduodenoscopy (EGD) where in Phase 1, we performed esophageal brushing through the endoscope under direct visualization and in Phase 2, we inserted the brush through a Cortrak® NGT prior to endoscopy...
June 14, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29905754/a-novel-signal-on-photoelectrochemical-sensor-for-ultrasensitive-detection-of-alkaline-phosphatase-activity-based-on-a-tio-2-g-c-3-n-4-heterojunction
#14
Feng Xia Wang, Cui Ye, Shi Mo, Liu Li Liao, Xiao Fang Zhang, Yu Ling, Lu Lu, Hong Qun Luo, Nian Bing Li
The use of alkaline phosphatase (ALP) as a biomarker in some diseases including hepatitis, obstructive jaundice, osteoblastic bone cancer, and osteomalacia is important in clinical diagnosis. Furthermore, ALP activity detection is an essential hot topic in environmental monitoring, biomedical research, and other research fields. In this study, a novel "signal-on" photoelectrochemical (PEC) biosensor based on the ALP-catalyzed phosphorylation reaction was designed to sensitively detect ALP activity...
June 15, 2018: Analyst
https://www.readbyqxmd.com/read/29905567/-study-of-total-antioocidant-status-of-the-organism-as-a-possible-biomarker-of-dose-and-effect-of-radiation-exposure
#15
I Gvilava, I Chkhikvishvili, T Sanikidze, M Giorgobiani, V N Kipiani, G Ormotsadze
In presented article, by means of a comparative analysis of the relationship between the dose-dependent alterations in the organism's redox status, measured by the innovative method developed by us and the standard methods used for assessing catalase and superoxide dismutase activity, and an end radiobiological effect, was attempted the preliminary assessment of the possibility to apply the parameter of blood plasma total antioxidant activity (TAA) as marker of dose and effect of radiation exposure. The experiments were carried out on white mice randomly divided into groups of irradiated and sham irradiated animals...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29905487/deducing-multiple-interfacial-dynamics-during-polymeric-foaming
#16
Mohammed Rehaan Chandan, Nilanjon Naskar, Anuja Das, Rabibrata Mukherjee, Gopalakrishna Pillai Harikrishnan
Several interfacial phenomena are active during polymeric foaming, the dynamics of which significantly influence terminal stability, cell structure and in turn the thermo-mechanical properties of temporally evolved foam. Understanding these dynamics is important in achieving desired foam properties. Here, we introduce a method to simultaneously portray the time evolution of bubble growth, lamella thinning and Plateau border drainage, occurring during reactive polymeric foaming. In this method, we initially conduct bulk and surface shear rheology under polymerizing and non-foaming conditions...
June 15, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29905465/pyrophosphate-induced-intramolecular-excimer-formation-in-dinuclear-zinc-ii-complexes-with-tetrakisquinoline-ligands
#17
Yuji Mikata, Risa Ohnishi, Risa Nishijima, Arimasa Matsumoto, Hideo Konno
Dinuclear Zn2+ complexes with HTQHPN ( N,N,N' ,N'-tetrakis(2-quinolylmethyl)-2-hydroxy-1,3-propanediamine) derivatives have been prepared, and their pyrophosphate (PPi, P2 O7 4- ) sensing properties were examined. The ligand library includes six HTQHPN derivatives with electron-donating/withdrawing substituents, an extended aromatic ring, and six-membered chelates upon zinc binding. Complexation of ligand with 2 equiv of Zn2+ promotes small to moderate fluorescence enhancement around 380 nm, but in the cases of HTQHPN, HT(6-FQ)HPN ( N,N,N' ,N'-tetrakis(6-fluoro-2-quinolylmethyl)-2-hydroxy-1,3-propanediamine), and HT(8Q)HPN ( N,N,N' ,N'-tetrakis(8-quinolylmethyl)-2-hydroxy-1,3-propanediamine), subsequent addition of PPi induced a significant fluorescence increase around 450 nm...
June 15, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29905354/-hpv-a-different-view-on-head-and-neck-cancer
#18
Claus Wittekindt, Steffen Wagner, Shachi Jenny Sharma, Nora Würdemann, Jennifer Knuth, Henrike Reder, Jens Peter Klußmann
Head and neck cancer is the sixth most common cancer with over 500000 annually reported incident cases worldwide. Besides major risk factors tobacco and alcohol, oropharyngeal squamous cell carcinomas (OSCC) show increased association with human papillomavirus (HPV). HPV-associated and HPV-negative OSCC are 2 different entities regarding biological characteristics, therapeutic response, and patient prognosis. In HPV OSCC, viral oncoprotein activity, as well as genetic (mutations and chromosomal aberrations) and epigenetic alterations plays a key role during carcinogenesis...
March 2018: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29905346/bilayers-of-janus-wsse-monitoring-the-stacking-type-via-the-vibrational-spectrum
#19
A Kandemir, H Sahin
Motivated by the recent successful synthesis of Janus type single layers of transition metal dichalcogenides, we investigate the stability, vibrational and electronic properties of the Janus single layer structure of WSSe and its bilayers by means of density functional theory. The structural and vibrational analysis show that the Janus single layer of WSSe forms a dynamically stable structure in the 2H phase. Owing to its non-centrosymmetric structure, the Janus WSSe single layer has two in-plane (E) and two out-of-plane (A) Raman active phonon modes...
June 15, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29905313/prevalence-and-risk-factors-for-genital-human-papillomavirus-infections-among-women-in-southwest-nigeria
#20
Y T Nejo, D O Olaleye, G N Odaibo
There is a great variation in the prevalence of cervical HPV infection worldwide with some of the highest rates being found in African women. Early onset of sexual activity (≤ 15 age), multiparity and sexual promiscuity have been recognized as some of the significant risk factors for HPV infection. In Nigeria, there is scarcity of data on the degree of relationship between these factors and the prevalence of HPV infection. Thus, this study was designed to determine the prevalence of genital HPV infection with its potential risk factors among women in Southwest Nigeria...
February 2018: Archives of basic and applied medicine
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