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https://www.readbyqxmd.com/read/29775127/glycemic-control-and-its-associated-factors-among-diabetes-mellitus-patients-at-ayder-comprehensive-specialized-hospital-mekelle-ethiopia
#1
Seifu Mideksa, Sintayehu Ambachew, Belete Biadgo, Habtamu Wondifraw Baynes
Diabetes is one of the largest health emergencies of the twenty-first century and it is increasing with alarming rate throughout the world. Glycemic Control in diabetes patients is an important issue in minimizing diabetes related complications and deaths. Institution based comparative cross-sectional study was conducted from March to April, 2017. Glycated Hemoglobin A1c and biochemical profiles were determined using Huma Meter A1c and ABX PENTRA 400 clinical chemistry analyzer. Independent t-test to compare groups, bivariate and multi variable logistic regression analysis were used...
May 18, 2018: Adipocyte
https://www.readbyqxmd.com/read/29775079/improved-glycemic-control-with-minimal-change-in-medication-regimen-complexity-in-a-pharmacist-endocrinologist-diabetes-intense-medical-management-dimm-tune-up-clinic
#2
Candis M Morello, Taylor Rotunno, John Khoan, Jan D Hirsch
BACKGROUND: Gaining glycemic control in patients with type 2 diabetes (T2D) usually requires more complicated medication regimens. Increased medication regimen complexity (MRC) negatively impacts adherence and clinical outcomes. OBJECTIVE: Compare MRC change in patients with uncontrolled T2D referred to a collaborative pharmacist-endocrinologist Diabetes Intense Medical Management (DIMM) clinic "tune up" model versus similar patients receiving usual primary care provider (PCP) care over 6 months...
May 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29773578/relationship-between-glycated-hemoglobin-and-stroke-risk-a-systematic-review-and-meta-analysis
#3
REVIEW
John Peter Mitsios, Elif Ilhan Ekinci, Gregory Peter Mitsios, Leonid Churilov, Vincent Thijs
BACKGROUND: Diabetes mellitus is a major risk factor for ischemic stroke. Rising hemoglobin A1c (HbA1c ) levels are associated with microvascular diabetes mellitus complication development; however, this relationship has not been established for stroke risk, a macrovascular complication. METHODS AND RESULTS: We conducted a systematic review and meta-analysis of observational cohort and nested case-control cohort studies assessing the association between rising HbA1c levels and stroke risk in adults (≥18 years old) with and without type 1 or type 2 diabetes mellitus...
May 17, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29773351/correlation-between-fibrinogen-and-white-matter-hyperintensities-among-nondiabetic-individuals-with-noncardiogenic-ischemic-stroke
#4
Cheng-Jin You, Dan Liu, Li-Li Liu, Qing-Qing Liu, Guo-Zhong Li
OBJECTIVE: The aim of the present study is to confirm the correlation between fibrinogen and the severity of cerebral white matter hyperintensities (WMHs) among nondiabetic patients with noncardiogenic acute ischemic stroke. PATIENTS AND METHODS: A cross-sectional study of 170 consecutive patients with noncardiogenic acute ischemic stroke who underwent magnetic resonance imaging and vascular imaging was conducted. WMHs were classified into periventricular hyperintensity (PVH) and deep and subcortical WMH (DSWMH) using Fazekas rating scale...
May 14, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29769078/the-effect-of-diabetes-self-management-education-on-hba1c-and-quality-of-life-in-african-americans-a-systematic-review-and-meta-analysis
#5
Amy T Cunningham, Denine R Crittendon, Neva White, Geoffrey D Mills, Victor Diaz, Marianna D LaNoue
BACKGROUND: Type 2 diabetes presents a major morbidity and mortality burden in the United States. Diabetes self-management education (DSME) is an intervention associated with improved hemoglobin A1c(HbA1c) and quality of life(QOL), and is recommended for all individuals with type 2 diabetes. African-Americans have disproportionate type 2 diabetes morbidity and mortality, yet no prior meta-analyses have examined DSME outcomes exclusively in this population. This systematic review and meta-analysis examined the impact of DSME on HbA1c and QOL in African-Americans compared to usual care...
May 16, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29768945/pharmacist-impact-on-treatment-intensification-and-hemoglobin-a-1c-in-patients-with-type-2-diabetes-mellitus-at-an-academic-health-center
#6
Kevin Cowart, Karen Sando
BACKGROUND: Achievement of treatment goals for patients with type 2 diabetes mellitus (T2DM) is suboptimal. This is in part driven by a lack of treatment intensification when warranted, termed "clinical inertia." OBJECTIVES: To investigate time to treatment intensification and changes in A1C among pharmacist-physician managed (PPM) patients compared to usual medical care (UMC) in patients with T2DM. METHODS: Retrospective matched cohort study at 2 academic family medicine clinics...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29768449/children-with-type-1-diabetes-who-experienced-a-honeymoon-phase-had-significantly-lower-ldl-cholesterol-5-years-after-diagnosis
#7
Benjamin Udoka Nwosu, Bo Zhang, Sanaa S Ayyoub, Stephanie Choi, Tony R Villalobos-Ortiz, Laura C Alonso, Bruce A Barton
IMPORTANCE: Landmark studies showed that partial clinical remission in new-onset type 1 diabetes is associated with reduced prevalence of long-term complications, but early clinical indicators of this favorable outcome are poorly characterized. AIM: To determine if there were any differences in lipid parameters, especially LDL-cholesterol, between remitters and non-remitters 4 to 5 years after the diagnosis of type 1 diabetes after controlling for hemoglobin A1c, body mass index, and pubertal status...
2018: PloS One
https://www.readbyqxmd.com/read/29768089/a-commentary-on-effects-of-regular-physical-activity-on-the-cognitive-performance-of-type-2-diabetic-patients-a-systematic-review-by-podolski-et-al-metab-syndr-relat-disord-2017-15-481-493
#8
Erin M Shellington, Sonja M Reichert, Robert J Petrella
Type 2 diabetes mellitus (T2DM) imparts an increased risk for cognitive decline, specifically executive function, which is important to maintain for diabetes self-management. There is evidence to suggest that exercise improves cognition in healthy older adults; however, the literature in adults with T2DM is lacking. This commentary is in complement to Podolski et al.'s systematic review evaluating the effects of physical activity on cognitive function in adults with T2DM. We have included eight additional studies and further highlight their conclusions on the heterogeneity of the literature thus far...
May 16, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29765613/basic-lifestyle-advice-to-individuals-at-high-risk-of-type-2-diabetes-a-2-year-population-based-diabetes-prevention-study-the-de-plan-intervention-in-the-hunt-study-norway
#9
Anne Jølle, Bjørn Olav Åsvold, Jostein Holmen, Sven Magnus Carlsen, Jaakko Tuomilehto, Johan Håkon Bjørngaard, Kristian Midthjell
Objective: Among individuals at high risk for diabetes identified through a population survey, we performed an intervention study with basic lifestyle advice aiming to prevent diabetes. Research design and methods: Among 50 806 participants in the HUNT3 Survey (2006-2008), 5297 individuals with Finnish Diabetes Risc Score (FINDRISC ≥15 were invited to an oral glucose tolerance test (OGTT) and an education session with lifestyle advice, and 2634 (49.7%) attended...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29762485/stress-induced-and-diabetic-hyperglycemia-associated-with-higher-mortality-among-intensive-care-unit-trauma-patients-cross-sectional-analysis-of-the-propensity-score-matched-population
#10
Meng-Wei Chang, Chun-Ying Huang, Hang-Tsung Liu, Yi-Chun Chen, Ching-Hua Hsieh
BACKGROUND: This study was designed to measure the effect of stress-induced hyperglycemia (SIH) and diabetic hyperglycemia (DH) versus non-diabetic normoglycemia (NDN) on the outcomes of trauma patients in the intensive care unit (ICU). METHODS: Diabetes mellitus (DM) was determined based on patient history and/or a hemoglobin A1c (HbA1c) level of ≥6.5% at admission. The patients who had serum glucose levels of ≥200 mg/dL in the absence or presence of DM were assigned into the groups SIH and DH, respectively...
May 15, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29760917/factors-associated-with-glycemic-status-and-ability-to-adapt-to-changing-demands-in-people-with-and-without-type-2-diabetes-mellitus-a-cross-sectional-study
#11
Bertha Cecilia Salazar-González, Esther C Gallegos-Cabriales, Alicia Rivera-Castillo, Arnulfo González-Cantú, Marco Vinicio Gómez-Meza, Jesús Zacarías Villarreal-Pérez
Objectives: Type 2 diabetes mellitus studies focus on metabolic indicators and different self-reported lifestyle or care behaviors. Self-reported instruments involve conscious process therefore responses might not reflect reality. Meanwhile implicit responses involve automatic, unconscious processes underlying social judgments and behavior. No studies have explored the combined influence of both metabolic indicators and implicit responses on lifestyle practices in type 2 diabetes mellitus patients...
2018: SAGE Open Medicine
https://www.readbyqxmd.com/read/29760346/effect-of-sitagliptin-on-coronary-flow-reserve-assessed-by-magnetic-resonance-imaging-in-type-2-diabetic-patients-with-coronary-artery-disease
#12
Keishi Moriwaki, Tetsushiro Takeuchi, Naoki Fujimoto, Toshiki Sawai, Yuichi Sato, Naoto Kumagai, Jun Masuda, Shiro Nakamori, Masaki Ishida, Norikazu Yamada, Mashio Nakamura, Hajime Sakuma, Masaaki Ito, Kaoru Dohi
BACKGROUND: The present study was conducted to assess the cardiovascular effects of dipeptidyl peptidase-4 inhibitors (DPP4i) on coronary flow reserve (CFR), left ventricular (LV) function and endothelial function of the peripheral artery by comparison with those of α-glucosidase inhibitors (αGI) in patients with type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD).Methods and Results:We randomly assigned 30 patients with T2DM and CAD to receive either sitagliptin or voglibose, and 28 patients (age 69±9 years, 75% male, hemoglobin A1c [HbA1c] 6...
May 12, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29759295/effect-of-acute-kidney-injury-after-percutaneous-mitral-valve-repair-on-outcome
#13
Maximilian Spieker, Katharina Hellhammer, Stratis Katsianos, Julian Wiora, Tobias Zeus, Patrick Horn, Malte Kelm, Ralf Westenfeld
Limited data exist on the occurrence of acute kidney injury (AKI) associated with percutaneous mitral valve repair (PMVR). The objectives of the present study were (1) to assess the prevalence of AKI after MitraClip (Abbott Vascular, Santa Clara, California) implantation, (2) to analyze the predictive factors of AKI, and (3) to evaluate the prognostic value of AKI after PMVR with a view to optimizing the management of high-risk patients. A total of 206 patients (serum creatinine [SCr] 1.3 ± 0.6 mg/dl, estimated glomerular filtration rate 55 ± 24 ml/min) who underwent PMVR were included...
April 17, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29758304/effects-of-behavioral-counseling-on-cardiometabolic-biomarkers-a-longitudinal-analysis-of-the-japanese-national-database
#14
Nayu Ikeda, Nobuo Nishi, Motohiko Miyachi
In Japan, health insurers are obliged to conduct Specific Health Checkup (SHC) for middle-aged and elderly persons. High-risk persons are referred to Specific Health Guidance (SHG) to receive behavioral counseling based on individual action plans including targets for modification of daily energy balance through diet and physical activity. Using individual-level observational data, we examined the effects of diet and physical activity counseling on cardiometabolic biomarkers across the country. Subjects were 363,440 high-risk persons aged 40-64 who participated in intensive support in SHG for ≥3 months between April 2008 and March 2012...
May 11, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29757485/tobacco-smoking-decreases-clinical-symptoms-of-gingivitis-in-patients-with-type-1-diabetes-a-cross-sectional-study
#15
Mateusz Tarnowski, Anna Duda-Sobczak, Jakub Lipski, Dorota Zozulinska-Ziolkiewicz, Marzena Wyganowska-Swiatkowska
OBJECTIVE: Periodontal disease may develop on the background of microvascular complications of diabetes. However, some modifying factors, such as tobacco smoking should be taken into consideration when assessing risk of development of chronic complications. The aim of the study was the clinical assessment of the periodontal status in patients with type 1 diabetes according to tobacco smoking. SUBJECTS AND METHODS: 362 subjects aged 29 (IQR 22-35) years, type 1 diabetes duration 12 (8-18) years, hemoglobin A1c, HbA1c 8...
May 14, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29757443/impact-of-genetic-polymorphism-in-the-%C3%AE-%C3%A2-receptor-gene-on-risk-of-severe-hypoglycemia-in-patients-with-type-1-diabetes
#16
Kim Zillo Rokamp, Niels Vidiendal Olsen, Louise Færch, Peter Lommer Kristensen, Birger Thorsteinsson, Ulrik Pedersen-Bjergaard
Context and Objective: Severe hypoglycemic events are unevenly distributed in subjects with type 1 diabetes making a genetic influence probable. The adrenergic beta-2-receptor gene (ADRB2) has several common polymorphisms of which the Arg16 allele is associated with receptor down-regulation and reduced agonist-mediated endogenous glucose production. We tested the hypothesis that the Arg16 variant is associated with severe hypoglycaemia. Method: A cohort of 311 subjects with type 1 diabetes reported severe hypoglycemic events retrospectively in a validated questionnaire...
May 10, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29757070/racial-ethnic-disparities-in-diabetes-diagnosis-and-glycemic-control-among-women-of-reproductive-age
#17
Laura E Britton, Jon M Hussey, Jamie L Crandell, Diane C Berry, Jada L Brooks, Amy G Bryant
BACKGROUND: Types 1 and 2 diabetes mellitus complicate pregnancies and threaten the health of women of reproductive age and their children. Among older adults, diabetes morbidity disproportionately burdens racial/ethnic minorities, but diabetes emergence among younger adults has not been as well characterized. The objective of this study was to describe the distribution of diagnosed diabetes, undiagnosed diabetes, suboptimal preconception glycemic control, and prediabetes among women of reproductive age across racial/ethnic backgrounds...
May 14, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29755756/treatment-choice-medication-adherence-and-glycemic-efficacy-in-people-with-type-2-diabetes-a-uk-clinical-practice-database-study
#18
Jason Gordon, Phil McEwan, Iskandar Idris, Marc Evans, Jorge Puelles
Objective: Using primary care data obtained from the UK Clinical Practice Research Datalink, this retrospective cohort study examined the relationships between medication adherence and clinical outcomes in patients with type 2 diabetes. Research design and methods: Data were extracted for patients treated between 2008 and 2016, and stratified by oral antihyperglycemic agent (OHA) line of therapy (mono, dual or triple therapy). Patients were monitored for up to 365 days; associations between medication possession ratio (MPR) and outcomes at 1 year (glycated hemoglobin A1c (HbA1c), weight and hypoglycemia incidence) were assessed using linear regression modeling and descriptive analyses...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29753982/does-urinary-bisphenol-a-change-after-bariatric-surgery
#19
Carl L Dambkowski, Luis Garcia, Natalia Leva, John M Morton
BACKGROUND: One of the world's highest volume chemicals is bisphenol-A (BPA), an organic compound with a high solubility in fat. An emerging body of literature has suggested a link between BPA and obesity and insulin resistance. The study aim is to determine if surgical weight loss is associated with changes in BPA levels. METHODS: Demographic, preoperative, and 3, 6, and 12 month postoperative urine and laboratory data were prospectively collected on 22 bariatric surgery patients at a single academic institution...
May 10, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29753232/traditional-and-nontraditional-glycemic-markers-and-risk-of-peripheral-artery-disease-the-atherosclerosis-risk-in-communities-aric-study
#20
Ning Ding, Lucia Kwak, Shoshana H Ballew, Bernard Jaar, Ron C Hoogeveen, Christie M Ballantyne, A Richey Sharrett, Aaron R Folsom, Gerardo Heiss, Maya Salameh, Josef Coresh, Alan T Hirsch, Elizabeth Selvin, Kunihiro Matsushita
BACKGROUND AND AIMS: Traditional glycemic markers, fasting glucose and hemoglobin A1c (HbA1c), predict incident peripheral artery disease (PAD). However, it is unknown whether nontraditional glycemic markers, fructosamine, glycated albumin, and 1,5-anhydroglucitol, are associated with PAD and whether these glycemic markers demonstrate particularly strong associations with severe PAD, critical limb ischemia (CLI). METHODS: We quantified the associations of these five glycemic markers with incident PAD (hospitalizations with PAD diagnosis or leg revascularization) in 11,634 ARIC participants using Cox regression models...
April 30, 2018: Atherosclerosis
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