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https://www.readbyqxmd.com/read/28332958/effect-of-prediabetes-on-allograft-survival-and-evolution-of-new-onset-diabetes-after-transplant-in-deceased-donor-kidney-transplant-recipients-during-long-term-follow-up
#1
Frank Peter Tillmann, Amira Radtke, Lars Christian Rump, Ivo Quack
OBJECTIVES: This study investigated the effect of prediabetes in long-term deceased-donor renal transplant recipients regarding graft survival, graft function, and evolution of new-onset diabetes after transplant compared with a control group of graft recipients with normal glucose tolerance test results. MATERIALS AND METHODS: This was a follow-up trial of 187 deceased-donor renal transplant recipients. Based on oral glucose tolerance test results, the cohort was divided into groups A and B, comprising individuals with normal glucose metabolism (n = 130, 69...
March 22, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28332894/incidence-and-progression-of-diabetic-retinopathy-in-urban-india-sankara-nethralaya-diabetic-retinopathy-epidemiology-and-molecular-genetics-study-sn-dreams-ii-report-1
#2
Rajiv Raman, Suganeswari Ganesan, Swakshyar Saumya Pal, Laxmi Gella, Vaitheeswaran Kulothungan, Tarun Sharma
PURPOSE: To evaluate the 4-year incidence and progression of and risk factors for diabetic retinopathy (DR) in an Indian population. METHODS: From a cross-sectional study of 1425 subjects with diabetes, 911 (63.9%) returned for 4-year follow-up. After excluding 21 with ungradable retinal images, data from 890 subjects were analyzed. Participants underwent examinations based on a standard protocol, which included grading of retinal photographs. RESULTS: The incidences of DR, diabetic macular edema (DME), and sight-threatening diabetic retinopathy (STDR) were 9...
March 23, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28332856/association-between-serum-gamma-glutamyl-transferase-and-serum-uric-acid-levels-in-chinese-females-a-cross-sectional-study
#3
Zhao Ya, Liu Fei, Zeng Yue, Liu Dan, Lin Neng-Bo, Luo Yi, Miao Ying, Wan Qin
OBJECTIVE: To investigate the association between serum gamma-glutamyl transferase (GGT) levels and serum uric acid levels in middle-aged and elderly Chinese females. METHODS: A cross-sectional population survey was performed in Luzhou, China (2014). Questionnaires, physical examinations and biochemical tests were conducted. Finally, we included 2486 females who were > 40 years old as participants. Multiple linear regression analysis was used to estimate the association of serum acid levels and other variables...
March 23, 2017: Endocrine Research
https://www.readbyqxmd.com/read/28332301/a-randomized-trial-comparing-gliclazide-liraglutide-and-metformin-effects-on-diabetes-with-nonalcoholic-fatty-liver-disease
#4
Wenhuan Feng, Caixia Gao, Yan Bi, Min Wu, Ping Li, Shanmei Shen, Wei Chen, Tingting Yin, Dalong Zhu
OBJECTIVE: To compare the effects of gliclazide, liraglutide, and metformin in type 2 diabetes mellitus (T2DM) patients with non-alcoholic fatty liver disease (NAFLD). METHODS: Eighty-seven subjects were randomized to receive liraglutide, metformin, or gliclazide for 24 weeks. Primary outcomes included hemoglobin A1c (HbA1c) levels, intrahepatic fat (IHF) content, and liver function. RESULTS: HbA1c levels and IHF content reduced after treatment in the three groups...
March 23, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28331456/primary-care-practice-reengineering-and-associations-with-patient-portal-use-service-utilization-and-disease-control-among-patients-with-hypertension-and-or-diabetes
#5
Eboni G Price-Haywood, Qingyang Luo
BACKGROUND: We describe the role of primary care reengineering in the Ochsner Health System (OHS) patient portal implementation strategy and compare subsequent trends in service utilization and disease control among portal users vs nonusers within this context. METHODS: This retrospective cohort study includes 101,019 patients with hypertension or diabetes who saw an OHS primary care provider (PCP) between 2012 and 2014. Inverse probability treatment weighting was used to reduce case-mix differences between study groups...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/28331117/comparison-between-effectiveness-of-100-mg-day-sitagliptin-and-a-switch-to-mitiglinide-calcium-hydrate-voglibose-from-50-mg-day-sitagliptin-in-patients-with-type-2-diabetes
#6
Tadashi Arao, Yosuke Okada, Keiichi Torimoto, Kei Sugai, Takashi Otsuka, Akira Kurozumi, Yoshiya Tanaka
We analyzed the effects of 100 mg/day sitagliptin and a switch to mitiglinide calcium hydrate/voglibose compound tablets (MIT/VOG) in patients with type 2 diabetes mellitus (T2DM) treated with 50 mg/day sitagliptin. Five patients with T2DM treated with 50 mg/day sitagliptin and hemoglobin A1c (HbA1c) of ≥6.5% were switched to MIT/VOG, or the dose of sitagliptin was increased to 100 mg/day. The effects of the changes in therapy were compared in a crossover fashion by continuous glucose monitoring. The primary endpoint was mean amplitude of glycemic excursions (MAGE), and the secondary end points were 24-hour mean blood glucose level and mean blood glucose level from 0:00 a...
2017: Journal of UOEH
https://www.readbyqxmd.com/read/28330952/effects-of-insulin-and-the-glucagon-like-peptide-1-receptor-agonist-liraglutide-on-the-kidney-proteome-in-db-db-mice
#7
Leena Liljedahl, Jenny Norlin, James N McGuire, Peter James
Diabetes mellitus (DM) is a worldwide disease that affects 9% of the adult world population and type 2 DM accounts for 90% of those. A common consequence of DM is kidney complications, which could lead to kidney failure. We studied the potential effects of treatment with insulin and the glucagon-like peptide 1 receptor (GLP-1R) agonist liraglutide on the diabetic kidney proteome through the use of the db/db mouse model system and mass spectrometry (MS). Multivariate analyses revealed distinct effects of insulin and liraglutide on the db/db kidney proteome, which was seen on the protein levels of, for example, pterin-4 α-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor-1α (PCBD1), neural precursor cell expressed developmentally down-regulated-8 (NEDD8), transcription elongation factor-B polypeptide-1 (ELOC) and hepcidin (HEPC)...
March 2017: Physiological Reports
https://www.readbyqxmd.com/read/28330731/diabetes-self-management-education-and-medical-nutrition-therapy-improve-patient-outcomes-a-pilot-study-documenting-the-efficacy-of-registered-dietitian-nutritionist-interventions-through-retrospective-chart-review
#8
Patricia Z Marincic, Amie Hardin, Maria V Salazar, Susan Scott, Shirley X Fan, Philippe R Gaillard
BACKGROUND: Diabetes self-management education (DSME) and medical nutrition therapy (MNT) improve patient outcomes; poor reimbursement limits access to care. OBJECTIVE: Our aim was to develop methodology for tracking patient outcomes subsequent to registered dietitian nutritionist interventions, document outcomes for patients with type 2 diabetes attending an American Diabetes Association-recognized program, and obtain outcome data to support reimbursement and public policy initiatives to improve patient access to DSME and MNT...
March 16, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28330678/acute-macular-edema-and-peripapillary-soft-exudate-after-pancreas-transplantation-with-accelerated-progression-of-diabetic-retinopathy
#9
Fang-Yi Tsai, Ling-Ing Lau, An-Fei Li, Shih-Jen Chen, Shin-E Wang, Fenq-Lih Lee, Catherine Jiu-Lin Liu, Yi-Ming Shyr
BACKGROUND: The effect of pancreas transplantation on diabetic retinopathy remains inconclusive. Herein, we report six patients with type 1 diabetes mellitus (DM) who underwent pancreas transplantation and developed acute macular edema and peripapillary soft exudate with rapid progression to proliferative diabetic retinopathy. METHODS: In this retrospective observational study, diabetic patients who underwent pancreas transplantation in a single medical center and developed symptomatic acute macular edema and peripapillary soft exudate within 3 months after the operation were enrolled...
March 18, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28329091/association-between-sleep-timing-obesity-diabetes-the-hispanic-community-health-study-study-of-latinos-hchs-sol-cohort-study-sleep-timing-obesity-and-diabetes
#10
Kristen L Knutson, Donghong Wu, Sanjay R Patel, Jose S Loredo, Susan Redline, Jianwen Cai, Linda C Gallo, Yasmin Mossavar-Rahmani, Alberto R Ramos, Yanping Teng, Martha L Daviglus, Phyllis C Zee
Study Objectives: Recent studies implicate inadequate sleep duration and quality in metabolic disease. Fewer studies have examined the timing of sleep, which may be important because of its potential impact on circadian rhythms of metabolic function. We examined the association between sleep timing and metabolic risk among Hispanic/Latino adults. Methods.: Cross-sectional data from community-based study of 13,429 participants aged 18-74 years. People taking diabetes medications were excluded...
January 28, 2017: Sleep
https://www.readbyqxmd.com/read/28329057/coronary-artery-calcification-and-risk-of-cardiovascular-disease-and-death-among-patients-with-chronic-kidney-disease
#11
Jing Chen, Matthew J Budoff, Muredach P Reilly, Wei Yang, Sylvia E Rosas, Mahboob Rahman, Xiaoming Zhang, Jason A Roy, Eva Lustigova, Lisa Nessel, Virginia Ford, Dominic Raj, Anna C Porter, Elsayed Z Soliman, Jackson T Wright, Myles Wolf, Jiang He
Importance: Coronary artery calcification (CAC) is highly prevalent in dialysis-naive patients with chronic kidney disease (CKD). However, there are sparse data on the association of CAC with subsequent risk of cardiovascular disease and all-cause mortality in this population. Objective: To study the prospective association of CAC with risk of cardiovascular disease and all-cause mortality among dialysis-naive patients with CKD. Design, Setting, and Participants: The prospective Chronic Renal Insufficiency Cohort study recruited adults with an estimated glomerular filtration rate of 20 to 70 mL/min/1...
March 22, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28326010/impact-of-resveratrol-on-glucose-control-hippocampal-structure-and-connectivity-and-memory-performance-in-patients-with-mild-cognitive-impairment
#12
Theresa Köbe, A Veronica Witte, Ariane Schnelle, Valentina A Tesky, Johannes Pantel, Jan-Philipp Schuchardt, Andreas Hahn, Jens Bohlken, Ulrike Grittner, Agnes Flöel
In healthy older adults, resveratrol supplementation has been shown to improve long-term glucose control, resting-state functional connectivity (RSFC) of the hippocampus, and memory function. Here, we aimed to investigate if these beneficial effects extend to individuals at high-risk for dementia, i.e., patients with mild cognitive impairment (MCI). In a randomized, double-blind interventional study, 40 well-characterized patients with MCI (21 females; 50-80 years) completed 26 weeks of resveratrol (200 mg/d; n = 18) or placebo (1,015 mg/d olive oil; n = 22) intake...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28325587/the-impact-of-allogenic-blood-transfusion-on-the-outcomes-of-total-pancreatectomy-with-islet-autotransplantation
#13
Gumpei Yoshimatsu, Rauf Shahbazov, Giovanna Saracino, Michael C Lawrence, Peter T Kim, Nicholas Onaca, Ernest E Beecherl, Bashoo Naziruddin, Marlon F Levy
BACKGROUND: Allogenic blood transfusion (ABT) may be needed for severe bleeding during total pancreatectomy with autotransplantation (TPIAT), but may induce inflammation. This study investigated the impact of ABT. METHODS: With a population of 83 patients who underwent TPIAT from 2006 to 2014, this study compared cytokine levels, patient characteristics, islet characteristics, metabolic outcomes, insulin requirements, and hemoglobin A1c for those who received a blood transfusion (BT) versus no blood transfusion (NBT)...
March 15, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28321057/the-glucose-lowering-efficacy-of-sitagliptin-in-obese-japanese-patients-with-type-2-diabetes
#14
Ryo Kodera, Kenichi Shikata, Akihiko Nakamura, Satoru Okazaki, Ryo Nagase, Tatsuaki Nakatou, Shigeru Haisa, Kazuyuki Hida, Katsuhiro Miyashita, Hirofumi Makino
Objective Dipeptidyl peptidase-4 (DPP-4) inhibitors are the most frequently prescribed oral hypoglycemic agents in Japan. Although a relationship between the efficacy of DPP-4 inhibitors and the body mass index (BMI) has been reported, this relationship is controversial. We investigated whether the BMI value affects the glucose-lowering efficacy of sitagliptin in obese Japanese patients with type 2 diabetes. Methods One hundred sixty-two outpatients with inadequate glycemic control were divided into four groups based on their baseline BMI values...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28318938/diabetes-nurse-case-management-in-a-canadian-tertiary-care-setting-results-of-a-randomized-controlled-trial
#15
Danni Li, Tom Elliott, Gerri Klein, Ehud Ur, Tricia S Tang
OBJECTIVES: To examine the effects of a 6-month nurse case manager (NCM) intervention compared to standard care (SC) on glycemic control and diabetes distress in a Canadian tertiary-care setting. METHODS: We recruited 140 adults with type 2 diabetes and glycated hemoglobin (A1C) levels >8% (64 mmol/mol) from 2 tertiary care facilities and randomized them to: 1) a 6-month NCM intervention in addition to SC or 2) SC by the primary endocrinologists. Assessments were conducted at baseline and at 6 months...
March 17, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28317813/association-between-pulmonary-tuberculosis-and-type-2-diabetes-in-sudanese-patients
#16
Mona Ahmed, Ibtihal Omer, Sannaa M A Osman, Eltayib H Ahmed-Abakur
INTRODUCTION: Tuberculosis (TB) and diabetes mellitus (DM) are both important health issues, and the association between DM and TB may be the next challenge for global TB control worldwide, type 2 DM (T2DM) responsible for 90% of DM cases. Persons with diabetes have a significantly increased risk of active TB, which is two to three times higher than in persons without diabetes. The aim of this study was to determine the association between pulmonary tuberculosis (PTB) and T2DM among Sudanese patients and also to determine the association between hemoglobin A1c (HbA1c) percentage in diabetic patients and development of PTB and effect of duration of T2DM in developing PTB...
January 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28317297/cardiometabolic-risk-factors-in-type-2-diabetes-with-high-fat-and-low-muscle-mass-at-baseline-and-in-response-to-exercise
#17
Tasuku Terada, Normand G Boulé, Mary Forhan, Carla M Prado, Glen P Kenny, Denis Prud'homme, Eiji Ito, Ronald J Sigal
OBJECTIVE: To examine the interplay between high fat and low muscle mass on cardiometabolic risk factors at baseline and in response to exercise in type 2 diabetes. METHODS: Using baseline percent body fat and skeletal muscle mass index, 248 participants were divided into high fat versus low fat and low muscle versus high muscle. Linear mixed models were used to examine the main effects of fat mass and muscle mass and their interaction on baseline cardiometabolic risk factors and changes in risk factors in response to 6-month exercise training...
March 20, 2017: Obesity
https://www.readbyqxmd.com/read/28303556/serum-fibroblast-growth-factor-1-is-associated-with-the-decreased-risk-of-obesity-in-human
#18
Jinzhou Zhu, Yuming Wang, Kefu Zhu, Jianguo Gao, Xingyong Wan, Xunlei Pang, Sujuan Fei
As a transducer of PPARγ signaling, recent evidence supports that fibroblast growth factor 1 (FGF1) mediates adipose tissue remodeling and insulin sensitivity. This study is to assess the role of serum FGF1 in obesity. A hospital-based case-control study of 154 subjects was conducted. Serum level of FGF1 was measured by enzyme-linked immunosorbent assay. The serum level of FGF1 in the lean (119.0 [103.1-146.1] pg/ml) was higher than it in the subjects with overweight/obesity (111.9 [80.3-127.4] pg/ml, P=0...
March 16, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28302903/differential-effects-of-dapagliflozin-on-cardiovascular-risk-factors-at-varying-degrees-of-renal-function
#19
Sergei Petrykiv, C David Sjöström, Peter J Greasley, John Xu, Frederik Persson, Hiddo J L Heerspink
BACKGROUND AND OBJECTIVE: Sodium glucose cotransporter 2 inhibition with dapagliflozin decreases hemoglobin A1c (HbA1c), body weight, BP, and albuminuria (urinary albumin-to-creatinine ratio). Dapagliflozin also modestly increases hematocrit, likely related to osmotic diuresis/natriuresis. Prior studies suggest that the HbA1c-lowering effects of dapagliflozin attenuate at lower eGFR. However, effects on other cardiovascular risk factors at different eGFR levels are incompletely understood...
March 16, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28301651/quantification-of-retinal-microvascular-density-in-optical-coherence-tomographic-angiography-images-in-diabetic-retinopathy
#20
Mary K Durbin, Lin An, Nathan D Shemonski, Mário Soares, Torcato Santos, Marta Lopes, Catarina Neves, Jose Cunha-Vaz
Importance: Quantitative measurements based on optical coherence tomographic angiography (OCTA) may have value in managing diabetic retinopathy (DR), but there is limited information on the ability of OCTA to distinguish eyes with DR. Objective: To evaluate the ability of measurements of retinal microvasculature using OCTA to distinguish healthy eyes from eyes with DR. Design, Setting, and Participants: In this prospective cross-sectional study, OCTA was used to examine the eyes of participants with type 2 diabetes with or without DR and the eyes of participants without diabetes from September 17, 2015, to April 6, 2016...
March 16, 2017: JAMA Ophthalmology
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