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Lipoxygenase

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https://www.readbyqxmd.com/read/28932020/role-of-the-cysteinyl-leukotrienes-in-the-pathogenesis-and-progression-of-cardiovascular-diseases
#1
REVIEW
Francesca Colazzo, Paolo Gelosa, Elena Tremoli, Luigi Sironi, Laura Castiglioni
Cysteinyl leukotrienes (CysLTs) are potent lipid inflammatory mediators synthesized from arachidonic acid, through the 5-lipoxygenase (5-LO) pathway. Owing to their properties, CysLTs play a crucial role in the pathogenesis of inflammation; therefore, CysLT modifiers as synthesis inhibitors or receptor antagonists, central in asthma management, may become a potential target for the treatment of other inflammatory diseases such as the cardiovascular disorders. 5-LO pathway activation and increased expression of its mediators and receptors are found in cardiovascular diseases...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28926992/the-native-fruit-geoffroea-decorticans-from-arid-northern-chile-phenolic-composition-antioxidant-activities-and-in-vitro-inhibition-of-pro-inflammatory-and-metabolic-syndrome-associated-enzymes
#2
Felipe Jiménez-Aspee, Cristina Theoduloz, Maria Del Pilar C Soriano, Maider Ugalde-Arbizu, Maria Rosa Alberto, Iris Catiana Zampini, Maria Inés Isla, Mario J Simirigiotis, Guillermo Schmeda-Hirschmann
The native tree Geoffroea decorticans (chañar) grows in the arid lands of northern Chile. It has been used as a food plant since prehistoric times. Phenolic-enriched extracts (PEEs) of Chilean chañar fruits were assessed for their chemical composition, antioxidant properties and inhibition of pro-inflammatory and metabolic syndrome-associated enzymes. Phenolic profiles were determined by HPLC-DAD-MS/MS. The PEEs of G. decorticans showed a strong effect towards the enzymes COX-1/COX-2, with inhibition percentages ranging from inactive to 92...
September 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28923202/dietary-linoleic-acid-and-its-oxidized-metabolites-exacerbate-liver-injury-caused-by-ethanol-via-induction-of-hepatic-proinflammatory-response-in-mice
#3
Dennis R Warner, Huilin Liu, Matthew E Miller, Christopher E Ramsden, Bin Gao, Ariel E Feldstein, Susanne Schuster, Craig J McClain, Irina A Kirpich
Alcoholic liver disease is a major human health problem leading to significant morbidity and mortality in the United States and worldwide. Dietary fat plays an important role in alcoholic liver disease pathogenesis. Herein, we tested the hypothesis that a combination of ethanol and a diet rich in linoleic acid (LA) leads to the increased production of oxidized LA metabolites (OXLAMs), specifically 9- and 13-hydroxyoctadecadienoic acids (HODEs), which contribute to a hepatic proinflammatory response exacerbating liver injury...
October 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28918545/increased-postharvest-life-of-tomlox-b-silenced-mutants-of-tomato-solanum-lycopersicum-var-ta234
#4
Elizabeth León-García, Gilber Vela-Gutiérrez, Oscar A Del Ángel-Coronel, Cristobal Torres-Palacios, Javier De La Cruz-Medina, Miguel A Gómez-Lim, Hugo Sergio García
A healthy lifestyle includes fruits and vegetables consumption. Tomato is one of the most consumed vegetables, although it is susceptible to physical damage through postharvest handling, thus leading to important losses. Softening is an important variable during tomato ripening; excessive softening is undesirable and leads to postharvest losses. TomloxB plays an important role in ripening, mainly in the loss of cellular integrity caused by fatty acids released from the lipid matrix of membranes that initiate oxidative deterioration, which is in turn carried into senescence...
September 16, 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/28918122/pre-harvest-uv-c-irradiation-triggers-vocs-accumulation-with-alteration-of-antioxidant-enzymes-and-phytohormones-in-strawberry-leaves
#5
Yanqun Xu, Zisheng Luo, Marie Thérèse Charles, Daniel Rolland, Dominique Roussel
Recent studies have highlighted the biological and physiological effects of pre-harvest ultraviolet (UV)-C treatment on growing plants. However, little is known about the involvement of volatile organic compounds (VOCs) and their response to this treatment. In this study, strawberry plants were exposed to three different doses of UV-C radiation for seven weeks (a low dose: 9.6kJm(-2); a medium dose: 15kJm(-2); and a high-dose: 29.4kJm(-2)). Changes in VOC profiles were investigated and an attempt was made to identify factors that may be involved in the regulation of these alterations...
September 8, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28915397/alleviation-of-cadmium-toxicity-in-lemna-minor-by-exogenous-salicylic-acid
#6
Qianqian Lu, Tingting Zhang, Wei Zhang, Chunlei Su, Yaru Yang, Dan Hu, Qinsong Xu
Cadmium (Cd) is a significant environmental pollutant in the aquatic environment. Salicylic acid (SA) is a ubiquitous phenolic compound. The goal of this study was to assess the morphological, physiological and biochemical changes in duckweed (L. minor) upon exposure to 10μM CdCl2, 10μM CdCl2 plus 50μM SA, or 50μM SA for 7 days. Reversing the effects of Cd, SA decreased Cd accumulation in plants, improved accumulation of minerals (Ca, Mg, Fe, B, Mo) absorption, increased endogenous SA concentration, and phenylalanine ammonialyase (PAL) activity...
September 12, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28904551/suppressive-effect-of-the-n-hexane-extract-of-litsea-japonica-fruit-flesh-on-monosodium-iodoacetate-induced-osteoarthritis-in-rats
#7
Seung-Hyung Kim, Hye-Jin Choi, Won-Kyung Yang, Ji-Eun Lee, Ju-Hyun Cho, In-Jae Park, Sunyoung Park, Bo-Kyung Park, Mirim Jin
We examined the antiosteoarthritic effect of the n-hexane extract of Litsea japonica fruit flesh (LJF-HE) in a rat model of monosodium-iodoacetate- (MIA-) induced osteoarthritis. LJF-HE significantly reduced the difference in weight-bearing capabilities of the hind paws between healthy and MIA-treated rats. Histological examination of the knee joints indicated that LJF-HE suppressed cartilage and bone destruction. Additionally, there were decreases in the expression of matrix metalloproteinase-2 and metalloproteinase-9 and cyclooxygenase-2 in the joints...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28903179/antinociceptive-anti-inflammatory-and-anxiolytic-like-effects-of-the-ethanolic-extract-fractions-and-hibalactone-isolated-from-hydrocotyle-umbellata-l-acari%C3%A3-oba-araliaceae
#8
Thiago Levi Silva Oliveira, Sandra Ribeiro de Morais, Stone de Sá, Matheus Gabriel de Oliveira, Iziara Ferreira Florentino, Dayane Moreira da Silva, Verônica Vale Carvalho, Vinícius Barreto da Silva, Boniek Gontijo Vaz, José Ricardo Sabino, Elson Alves Costa, José Realino de Paula
Hydrocotyle umbellata Linn. (Araliaceae) is specie used in the treatment of inflammatory diseases. Crude extract (E-HU) was prepared from H. umbellata subterraneous parts and fractionated by liquid-liquid partition, resulting hexane fraction (HF-HU), dichloromethane fraction (DF-HU), ethyl acetate fraction (EAF-HU) and aqueous fraction (AF-HU). The hibalactone (HU-1) was isolated from the DF-HU and its structure was elucidated by (1)H NMR and (13)C NMR Spectroscopy, mass spectrometry and crystallographic x-ray analysis...
September 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28894350/short-term-regulation-of-fc%C3%AE-r-mediated-phagocytosis-by-tlrs-in-macrophages-participation-of-5-lipoxygenase-products
#9
Carla da S Pinheiro, Ana Paula T Monteiro, Fabiano F Dutra, Marcelo T Bozza, Marc Peters-Golden, Claudia F Benjamim, Claudio Canetti
TLRs recognize a broad spectrum of microorganism molecules, triggering a variety of cellular responses. Among them, phagocytosis is a critical process for host defense. Leukotrienes (LTs), lipid mediators produced from 5-lipoxygenase (5-LO) enzyme, increase FcγR-mediated phagocytosis. Here, we evaluated the participation of TLR2, TLR3, TLR4, and TLR9 in FcγR-mediated phagocytosis and whether this process is modulated by LTs. Rat alveolar macrophages (AMs), murine bone marrow-derived macrophages (BMDMs), and peritoneal macrophages (PMs) treated with TLR2, TLR3, and TLR4 agonists, but not TLR9, enhanced IgG-opsonized sheep red blood cell (IgG-sRBC) phagocytosis...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28892009/nrf2-activation-by-5-lipoxygenase-metabolites-in-human-umbilical-vascular-endothelial-cells
#10
Nozomi Nagahora, Hidetoshi Yamada, Sayaka Kikuchi, Mayuka Hakozaki, Akira Yano
5-hydroxyeicosatetraenoic acid (5-HETE) and 5-hydroxyeicosapentaenoic acid (5-HEPE) are major metabolites produced by 5-lipoxygenase (5-LOX) from arachidonic acid (AA) and eicosapentaenoic acid (EPA). Effects of hydroxides on endothelial cells are unclear, although 5-LOX is known to increase at arteriosclerotic lesions. To investigate the effects of hydroxides on human umbilical vein endothelial cells (HUVECs), the cells were treated with 50 μM each of AA, EPA, 5-HETE, and 5-HEPE. Treatment of HUVECs with 5-HETE and 5-HEPE, rather than with AA and EPA, increased the nuclear translocation of NF-E2 related factor 2 (Nrf2) and upregulated the expression of heme oxygenase-1 and cystine/glutamate transporter regulated by Nrf2...
September 11, 2017: Nutrients
https://www.readbyqxmd.com/read/28889752/covalent-immobilization-of-oxylipin-biosynthetic-enzymes-on-nanoporous-rice-husk-silica-for-production-of-cis-12-oxophytodienoic-acid
#11
Thu Bao Le, Chong Soo Han, Kyoungwon Cho, Oksoo Han
Soybean lipoxygenase, recombinant rice allene oxide synthase-1 and rice allene oxide cyclase were covalently immobilized on nanoporous rice husk silica using two types of linkers: glutardialdehyde and polyethylene glycol. The immobilization efficiency achieved using glutardialdehyde-linked rice husk silica was higher than that achieved using polyethylene glycol-linked rice husk silica (50-92% and 25-50%, respectively). Immobilization on both types of matrices significantly decreased the specific activities of the immobilized enzymes...
September 11, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28888620/the-caspase-8-bid-cytochrome-c-axis-links-signals-from-death-receptors-to-mitochondrial-reactive-oxygen-species-production
#12
Wan-Sung Kim, Kwang-Soon Lee, Ji-Hee Kim, Chun-Ki Kim, Gwangsoo Lee, Jongseon Choe, Moo-Ho Won, Tae-Hyoung Kim, Dooil Jeoung, Hansoo Lee, Ji-Yoon Kim, Mi Ae Jeong, Kwon-Soo Ha, Young-Guen Kwon, Young-Myeong Kim
Ligation of the death receptors for TNF-α, FasL, and TRAIL triggers two common pathways, caspase-dependent intrinsic apoptosis and intracellular reactive oxygen species (ROS) generation. The apoptotic pathway is well characterized; however, a signaling linker between the death receptor and ROS production has not been clearly elucidated. Here, we found that death receptor-induced ROS generation was strongly inhibited by mitochondrial complex I and II inhibitors, but not by inhibitors of NADPH oxidase, lipoxygenase, cyclooxygenase or xanthine oxidase, indicating that ROS are mostly generated by the impairment of the mitochondrial respiratory chain...
September 6, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28887514/dormant-5-lipoxygenase-in-inflammatory-macrophages-is-triggered-by-exogenous-arachidonic-acid
#13
Carlos A Sorgi, Simona Zarini, Sarah A Martin, Raphael L Sanchez, Rodrigo F Scandiuzzi, Miguel A Gijón, Carlos Guijas, Nicolas Flamand, Robert C Murphy, Lucia H Faccioli
The differentiation of resident tissue macrophages from embryonic precursors and that of inflammatory macrophages from bone marrow cells leads to macrophage heterogeneity. Further plasticity is displayed through their ability to be polarized as subtypes M1 and M2 in a cell culture microenvironment. However, the detailed regulation of eicosanoid production and its involvement in macrophage biology remains unclear. Using a lipidomics approach, we demonstrated that eicosanoid production profiles between bone marrow-derived (BMDM) and peritoneal macrophages differed drastically...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28887380/proteomic-signature-reveals-modulation-of-human-macrophage-polarization-and-functions-under-differing-environmental-oxygen-conditions
#14
Magali Court, Graciane Petre, Michèle El-Atifi, Arnaud Millet
Macrophages are innate immune cells which can react to a large number of environmental stimuli thanks to a high degree of plasticity. These cells are involved in a variety of tissue functions in homeostasis, and they play essential roles in pathological contexts. Macrophages’ activation state, which determines their functional orientation, is strongly influenced by the cellular environment. A large body of macrophage literature is devoted to better defining polarizations from a molecular viewpoint. It is now accepted that a multidimensional model of polarization is needed to grasp the broad phenotype repertoire controlled by environmental signals...
September 8, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28886991/molecular-mechanisms-of-nonalcoholic-fatty-liver-disease-potential-role-for-12-lipoxygenase
#15
REVIEW
Niharika Samala, Sarah A Tersey, Naga Chalasani, Ryan M Anderson, Raghavendra G Mirmira
Nonalcoholic fatty liver disease (NAFLD) is a spectrum of pathologies associated with fat accumulation in the liver. NAFLD is the most common cause of liver disease in the United States, affecting up to a third of the general population. It is commonly associated with features of metabolic syndrome, particularly insulin resistance. NAFLD shares the basic pathogenic mechanisms with obesity and insulin resistance, such as mitochondrial, oxidative and endoplasmic reticulum stress. Lipoxygenases catalyze the conversion of poly-unsaturated fatty acids in the plasma membrane-mainly arachidonic acid and linoleic acid-to produce oxidized pro-inflammatory lipid intermediates...
July 31, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28886714/the-oxylipin-and-endocannabidome-responses-in-acute-phase-plasmodium-falciparum-malaria-in-children
#16
Izabella Surowiec, Sandra Gouveia-Figueira, Judy Orikiiriza, Elisabeth Lindquist, Mari Bonde, Jimmy Magambo, Charles Muhinda, Sven Bergström, Johan Normark, Johan Trygg
BACKGROUND: Oxylipins and endocannabinoids are low molecular weight bioactive lipids that are crucial for initiation and resolution of inflammation during microbial infections. Metabolic complications in malaria are recognized contributors to severe and fatal malaria, but the impact of malaria infection on the production of small lipid derived signalling molecules is unknown. Knowledge of immunoregulatory patterns of these molecules in malaria is of great value for better understanding of the disease and improvement of treatment regimes, since the action of these classes of molecules is directly connected to the inflammatory response of the organism...
September 8, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28886446/interaction-of-zinc-ii-with-the-non-steroidal-anti-inflammatory-drug-niflumic-acid
#17
Alketa Tarushi, Catherine P Raptopoulou, Vassilis Psycharis, Dimitris P Kessissoglou, Athanasios N Papadopoulos, George Psomas
The reaction of ZnCl2 with the non-steroidal anti-inflammatory drug niflumic acid (Hnif) resulted in the formation of complex [Zn(nif-O)2(MeOH)4], 1. When this reaction was performed in the presence of a N,N'-donor heterocyclic ligand such as 2,2'-bipyridine (bipy), 2,2'-bipyridylamine (bipyam), 1,10-phenanthroline (phen) and 2,2'-dipyridylketone oxime (Hpko), the complexes [Zn(nif-O,O')(bipy)Cl], 2, [Zn(nif-O)(nif-O,O')2(bipyam)], 3, [Zn(nif-O,O')2(phen)], 4 and [Zn(nif-O)2(Hpko-N,N')2], 5 were formed, respectively...
September 1, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28886174/development-of-hop-transcriptome-to-support-research-into-host-viroid-interactions
#18
Tine Pokorn, Sebastjan Radišek, Branka Javornik, Nataša Štajner, Jernej Jakše
Viroids, the smallest known pathogens, unable to encode any proteins, can cause severe diseases in their host plants. One of the proposed mechanisms of their pathogenicity includes silencing the host's genes via viroid-derived small RNAs, which are products of the host's immune response to the viroid's double stranded RNA. Humulus lupulus (hop) plants are hosts to several viroids; two of them, HLVd and CBCVd, are interesting models for studying host-viroid interactions, due to the symptomless infection of the former and severe stunting disease caused by the latter...
2017: PloS One
https://www.readbyqxmd.com/read/28886129/modulation-of-the-endogenous-omega-3-fatty-acid-and-oxylipin-profile-in-vivo-a-comparison-of-the-fat-1-transgenic-mouse-with-c57bl-6-wildtype-mice-on-an-omega-3-fatty-acid-enriched-diet
#19
Annika I Ostermann, Patrick Waindok, Moritz J Schmidt, Cheng-Ying Chiu, Christopher Smyl, Nadine Rohwer, Karsten-H Weylandt, Nils Helge Schebb
Dietary intervention and genetic fat-1 mice are two models for the investigation of effects associated with omega-3 polyunsaturated fatty acids (n3-PUFA). In order to assess their power to modulate the fatty acid and oxylipin pattern, we thoroughly compared fat-1 and wild-type C57BL/6 mice on a sunflower oil diet with wild-type mice on the same diet enriched with 1% EPA and 1% DHA for 0, 7, 14, 30 and 45 days. Feeding led after 14-30 days to a high steady state of n3-PUFA in all tissues at the expense of n6-PUFAs...
2017: PloS One
https://www.readbyqxmd.com/read/28874441/comprehensive-analyses-of-oxidized-phospholipids-using-a-measured-ms-ms-spectra-library
#20
Ryohei Aoyagi, Kazutaka Ikeda, Yosuke Isobe, Makoto Arita
Oxidized phospholipids (OxPLs) are widely held to be associated with various diseases such as arteriosclerosis, diabetes and cancer. To characterize the structure-specific behavior of OxPLs and their physiological relevance, we developed a comprehensive analytical method by establishing a measured MS/MS spectra library of OxPLs . Biogenic OxPLs were prepared by the addition of specific oxidized fatty acids to cultured cells, where they were incorporated into cellular phospholipids, and untargeted lipidomics by LC-quadrupole/time-of-flight (QTOF) MS was applied to collect MS/MS spectra for the OxPLs...
September 5, 2017: Journal of Lipid Research
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