keyword
MENU ▼
Read by QxMD icon Read
search

Ischemia reperfusion hemorrhage

keyword
https://www.readbyqxmd.com/read/27884324/postconditioning-with-sevoflurane-ameliorates-spatial-learning-and-memory-deficit-after-hemorrhage-shock-and-resuscitation-in-rats
#1
Xianwen Hu, Jingxian Wang, Qiquan Zhang, Xiaowen Duan, Zhiwu Chen, Ye Zhang
BACKGROUND: Severe hemorrhage shock and resuscitation are a systemic ischemia-reperfusion phenomenon which can induce learning and memory deficit in human and rats. Sevoflurane postconditioning has been proved to offer neuroprotection under different setting of cerebral ischemia-reperfusion in rats. The aim of this study was to investigate whether sevoflurane postconditioning could improve spatial learning and memory ability after hemorrhage shock and resuscitation in rats. METHODS: Thirty-five male rats were randomized into five groups: sham group, shock group, low concentration (sevo1, 1...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27863349/trpv1-channels-in-cardiovascular-system-a-double-edged-sword
#2
REVIEW
Puneet Kaur Randhawa, Amteshwar Singh Jaggi
Apart from modulating nociception, there is vital role of TRPV1 channels in modulating atherosclerosis, congestive heart failure, systemic hypertension, pulmonary hypertension, hemorrhagic shock and vascular remodeling. TRPV1 channel activation has shielding effect against the development of atherosclerosis and systemic hypertension. TRPV1 channel activation alleviates the formation of atherosclerotic lesions via increasing the expression of cholesterol efflux regulatory protein, UCP 2 and enhancing autophagy...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27830023/over-expression-of-heat-shock-protein-70-protects-mice-against-lung-ischemia-reperfusion-injury-through-sirt1-ampk-enos-pathway
#3
Shumei Liu, Junping Xu, Chunfang Fang, Chunjing Shi, Xin Zhang, Bo Yu, Yantong Yin
Lung ischemia/reperfusion injury (LIRI) usually occurs during in lung transplantation and extracorporeal circulation operation and may develop into pulmonary infections, acute rejection and bronchiolitis obliterans syndrome. Recent studies have discovered the protective effect of heat shock protein 70 (HSP70) on various types of injuries. In the present study, we firstly explore the role of over-expressed HSP70 on the protection against LIRI. Lung Wet/Dry (W/D) ratio, biomarkers in the bronchoalveolar lavage fluid (BALF), lung histological changes and apoptosis markers, oxidative products and proinflammatory cytokines in the lung tissues were analyzed...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27816279/efficacy-of-early-superficial-temporal-artery-middle-cerebral-artery-double-anastomoses-for-atherosclerotic-occlusion-in-patients-with-progressing-stroke
#4
Akihiro Inoue, Kanehisa Kohno, Shinji Iwata, Shiro Ohue, Saya Ozaki, Satoko Ninomiya, Hitomi Tomita, Kenji Kamogawa, Kensho Okamoto, Shinya Fukumoto, Haruhisa Ichikawa, Shinji Onoue, Yawara Nakamura, Bungo Okuda
BACKGROUND: We investigated the efficacy of early superficial temporal artery-middle cerebral artery (STA-MCA) double anastomoses for patients with progressing stroke due to atherosclerotic occlusion. MATERIALS AND METHODS: Nine consecutive patients who underwent early STA-MCA double anastomoses were enrolled. All patients presented with progressing stroke despite maximal medical treatment. Cerebral blood flow in 7 patients was analyzed by single-photon emission tomography...
November 2, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27812152/the-comparison-of-the-outcomes-between-primary-pci-fibrinolysis-and-no-reperfusion-in-patients-%C3%A2-75-years-old-with-st-segment-elevation-myocardial-infarction-results-from-the-chinese-acute-myocardial-infarction-cami-registry
#5
He Peiyuan, Yang Jingang, Xu Haiyan, Gao Xiaojin, Xian Ying, Wu Yuan, Li Wei, Wang Yang, Tang Xinran, Yan Ruohua, Jin Chen, Song Lei, Zhang Xuan, Fu Rui, Ye Yunqing, Dong Qiuting, Sun Hui, Yan Xinxin, Gao Runlin, Yang Yuejin
BACKGROUND: Only a few randomized trials have analyzed the clinical outcomes of elderly ST-segment elevation myocardial infarction (STEMI) patients (≥ 75 years old). Therefore, the best reperfusion strategy has not been well established. An observational study focused on clinical outcomes was performed in this population. METHODS: Based on the national registry on STEMI patients, the in-hospital outcomes of elderly patients with different reperfusion strategies were compared...
2016: PloS One
https://www.readbyqxmd.com/read/27809248/the-molecular-pathway-of-argon-mediated-neuroprotection
#6
REVIEW
Felix Ulbrich, Ulrich Goebel
The noble gas argon has attracted increasing attention in recent years, especially because of its neuroprotective properties. In a variety of models, ranging from oxygen-glucose deprivation in cell culture to complex models of mid-cerebral artery occlusion, subarachnoid hemorrhage or retinal ischemia-reperfusion injury in animals, argon administration after individual injury demonstrated favorable effects, particularly increased cell survival and even improved neuronal function. As an inert molecule, argon did not show signs of adverse effects in the in vitro and in vivo model used, while being comparably cheap and easy to apply...
October 31, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27774630/redox-dependent-regulation-of-hepatocyte-aim2-inflammasome-activation-in-sterile-liver-injury-in-mice
#7
Qian Sun, Patricia Loughran, Richard Shapiro, Indira H Shrivastava, Daniel J Antoine, Tunliang Li, Zhengzheng Yan, Jie Fan, Timothy R Billiar, Melanie J Scott
: Sterile liver inflammation, such as liver ischemia reperfusion, hemorrhagic shock after trauma and drug-induced liver injury is initiated and regulated by endogenous mediators including DNA and reactive oxygen species. Here we identify a novel mechanism for redox-mediated regulation of AIM2-inflammasome activation in hepatocytes after redox stress in mice, which occurs via interaction with cytosolic HMGB1. We show that in liver during hemorrhagic shock in mice, and in hepatocytes after hypoxia with reoxygenation, cytosolic HMGB1 associates with AIM2 and is required for activation of caspase-1 in response to cytosolic DNA...
October 24, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27759558/a-novel-technique-of-subclavian-artery-cannulation-for-venoarterial-extracorporeal-membrane-oxygenation
#8
Umit Kervan, Sinan Sabit Kocabeyoglu, Dogan Emre Sert, Emre Aygün, Kemal Kavasoglu, Mehmet Karahan, Ertekin Utku Unal, Mustafa Pac
OBJECTIVES: The common femoral artery is the standard site for immediate vascular access when initiating adult venoarterial extracorporeal membrane oxygenation. However, this approach is fraught with problems such as femoral artery occlusion, distal limb ischemia, reperfusion injury resulting in compartment syndrome, retroperitoneal hemorrhage, thrombosis, embolization, and most importantly, pulmonary edema. Here, we show our preference of using the subclavian artery with a side graft as a different cannulation technique for outflow of extracorporeal membrane oxygenation, which can avoid complications associated with different access techniques...
October 14, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27706770/activation-of-p38-mitogen-activated-protein-kinase-contributes-to-ischemia-reperfusion-in-rat-brain
#9
Y Q Song, H L Zou, Y J Zhao, L Q Yu, Z X Tan, R Kong
Inflammation plays an important role in cerebral ischemia reperfusion, which can cause severe damage to the brain and may lead to cerebral hemorrhage transformation. p38-mitogen-activated protein kinase (p38mapk) has been implicated in the etiology of a number of diseases because it is a cause of inflammation, but comparatively little research has been carried out into its role in the etiology of ischemia reperfusion. We investigated the expression of p38mapk in cerebral ischemia reperfusion to gain a better understanding of its potential role in hemorrhagic transformation (HT)...
September 23, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27690096/effects-of-n-3-pufas-on-intestinal-mucosa-innate-immunity-and-intestinal-microbiota-in-mice-after-hemorrhagic-shock-resuscitation
#10
Feng Tian, Xuejin Gao, Li Zhang, Xinying Wang, Xiao Wan, Tingting Jiang, Chao Wu, Jingcheng Bi, Qiucheng Lei
n-3 polyunsaturated fatty acids (PUFAs) can improve the function of the intestinal barrier after damage from ischemia-reperfusion or hemorrhagic shock resuscitation (HSR). However, the effects of n-3 PUFAs on intestinal microbiota and the innate immunity of the intestinal mucosa after HSR remain unclear. In the present study, 40 C57BL/6J mice were randomly assigned to five groups: control, sham, HSR, HSR + n-3 PUFAs and HSR + n-6 PUFAs. Mice were sacrificed 12 h after HSR. Liver, spleen, mesenteric lymph nodes and terminal ileal tissues were collected...
2016: Nutrients
https://www.readbyqxmd.com/read/27677785/complement-c3-inhibitor-cp40-attenuates-xenoreactions-in-pig%C3%A2-hearts-perfused-with-human-blood
#11
Jan-Michael Abicht, Ioannis Kourtzelis, Bruno Reichart, Sophia Koutsogiannaki, Alexandra Primikyri, John D Lambris, Triantafyllos Chavakis, Lesca Holdt, Alexander Kind, Sonja Guethoff, Tanja Mayr
BACKGROUND: The complement system plays a crucial role in acute xenogeneic reactions after cardiac transplantation. We used an ex vivo perfusion model to investigate the effect of Cp40, a compstatin analog and potent inhibitor of complement at the level of C3. METHODS: Fifteen wild-type pig hearts were explanted, cardiopleged, and reperfused ex vivo after 150 minutes of cold ischemia. Hearts were challenged in a biventricular working heart mode to evaluate cardiac perfusion and function...
September 27, 2016: Xenotransplantation
https://www.readbyqxmd.com/read/27677185/lipoic-acid-use-and-functional-outcomes-after-thrombolysis-in-patients-with-acute-ischemic-stroke-and-diabetes
#12
Kang-Ho Choi, Man-Seok Park, Joon-Tae Kim, Hyung-Seok Kim, Ja-Hae Kim, Tai-Seung Nam, Seong-Min Choi, Seung-Han Lee, Byeong-Chae Kim, Myeong-Kyu Kim, Ki-Hyun Cho
BACKGROUND: Alpha-lipoic acid (aLA) is a strong antioxidant commonly used for treating diabetic polyneuropathy. Previously, we demonstrated the neurorestorative effects of aLA after cerebral ischemia in rats. However, its effects on patients with stroke remain unknown. We investigated whether patients treated with aLA have better functional outcomes after acute ischemic stroke (AIS) and reperfusion therapy than patients not receiving aLA. METHODS: In this retrospective study of 172 prospectively registered patients with diabetes and AIS treated with tissue plasminogen activator (tPA), we investigated the relationship between aLA use and functional outcome both after 3 months and after 1 year...
2016: PloS One
https://www.readbyqxmd.com/read/27624481/guhong-injection-protects-against-focal-cerebral-ischemia-reperfusion-injury-via-anti-inflammatory-effects-in-rats
#13
Jinchao Ai, Haitong Wan, Mingchun Shu, Huifen Zhou, Tao Zhao, Wei Fu, Yu He
Guhong injection (GHI), composed of aceglutamide and safflower aqueous extract, has been used clinically for the treatment of cerebrovascular diseases such as cerebral embolism, hemorrhage and mental deterioration. In this paper, we reported the results of the first study on the anti-inflammatory effects of GHI in murine focal cerebral ischemia-reperfusion (I/R) injury. Adult male SD rats were randomly divided into six groups: Sham group, I/R group, GHI-L group (2.5 mL/kg), GHI-M group (5 mL/kg), GHI-H group (10 mL/kg) and Nimodipine group...
September 13, 2016: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/27604729/animal-stroke-model-ischemia-reperfusion-and-intracerebral-hemorrhage
#14
Changhong Ren, Christopher Sy, Jinhuan Gao, Yuchuan Ding, Xunming Ji
Stroke is a major health issue worldwide-one with serious financial and public health implications. As a result, ongoing clinical research on novel and improved stroke therapies is not only pertinent but also paramount. Due to the complexity of a stroke-like event and its many sequelae, devising usable methods and experimental models are necessary to study and better understand the pathophysiological processes that ensue. As it stands, animal models that simulate stroke-like events have proven to be the most logical and effective options in regards to experimental studies...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27601882/effects-of-alprostadil-and-iloprost-on-renal-lung-and-skeletal-muscle-injury-following-hindlimb-ischemia-reperfusion-injury-in-rats
#15
Dilek Erer, Abdullah Özer, Hüseyin Demirtaş, İpek Işık Gönül, Halil Kara, Hande Arpacı, Faruk Metin Çomu, Gürsel Levent Oktar, Mustafa Arslan, Ayşegül Küçük
OBJECTIVES: To evaluate the effects of alprostadil (prostaglandin [PGE1] analog) and iloprost (prostacyclin [PGI2] analog) on renal, lung, and skeletal muscle tissues after ischemia reperfusion (I/R) injury in an experimental rat model. MATERIALS AND METHODS: Wistar albino rats underwent 2 hours of ischemia via infrarenal aorta clamping with subsequent 2 hours of reperfusion. Alprostadil and iloprost were given starting simultaneously with the reperfusion period...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27570771/autologous-endothelial-progenitor-cells-improve-allograft-survival-in-porcine-lung-transplantation-with-prolonged-ischemia
#16
Yi-Ting Yen, Jun-Neng Roan, Shih-Yuan Fang, Shi-Wei Chang, Yau-Lin Tseng, Chen-Fuh Lam
BACKGROUND: As endothelial progenitor cells (EPCs) attenuated acute lung injury (ALI) in rabbit model, we hypothesized that autologous EPCs preserved lung graft function during the acute reperfusion period of lung transplantation and tested the therapeutic potential of EPCs in a porcine model of lung transplantation with prolonged graft ischemia. METHODS: Day-7 EPCs isolated from the recipient subjects or plain culture media were administered into the left pulmonary artery immediately before restoration of pulmonary blood flow in a porcine lung allotransplantation model, with the transplantation surgeons blinded to the content of injection...
August 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27566245/the-glucagon-like-peptide-1-receptor-agonist-exendin-4-ameliorates-warfarin-associated-hemorrhagic-transformation-after-cerebral-ischemia
#17
Fangzhe Chen, Weifeng Wang, Hongyan Ding, Qi Yang, Qiang Dong, Mei Cui
BACKGROUND: As the number of patients with cardioembolic ischemic stroke is predicted to be double by 2030, increased burden of warfarin-associated hemorrhagic transformation (HT) after cerebral ischemia is an expected consequence. However, thus far, no effective treatment strategy is available for HT prevention in routine clinical practice. While the glucagon-like peptide-1 receptor (GLP-1R) agonist exendin-4 (Ex-4) is known to protect against oxidative stress and neuronal cell death caused by ischemic brain damage, its effect on preventing warfarin-associated HT after cerebral ischemia is yet unknown...
2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27560521/increased-plasma-matrix-metalloproteinase-9-levels-contribute-to-intracerebral-hemorrhage-during-thrombolysis-after-concomitant-stroke-and-influenza-infection
#18
Sajjad Muhammad, Oliver Planz, Markus Schwaninger
BACKGROUND: Thrombolysis is the only approved therapy for acute stroke. However, life-threatening complications such as intracerebral hemorrhage (ICH) can develop after intravenous administration of tissue plasminogen activator (tPA). Both infection and thrombolysis during cerebral ischemia disrupt the blood-brain barrier (BBB). tPA can induce matrix metalloproteinase-9 (MMP-9), which is known to be involved in BBB disruption. However, it has still not been investigated whether preexisting influenza virus infection during thrombolysis after acute stroke affects systemic levels of MMP-9 and its inhibitor TIMP-1 and whether increased systemic MMP-9 levels affect ICH...
2016: Cerebrovascular Diseases Extra
https://www.readbyqxmd.com/read/27557615/effect-of-kineret%C3%A2-on-ovarian-ischemia-reperfusion-injury-in-a-rat-model
#19
Umit Arslan Nayki, Cenk Nayki, Nihal Cetin, Ferda Keskin Cimen, Abdulkadir Coban, Renad Mammadov, Ismail Hakkı Tas, Ismail Malkoc
AIM: To investigate the effect of Kineret® on ischemia reperfusion (IR) injury in rat ovaries. METHODS: Rats were divided into four groups: ovarian IR (IRG); 50 mg/kg Kineret® + ovarian IR (KIR-50); 100 mg/kg Kineret® + ovarian IR (KIR-100); and sham operation (SOC). KIR-50 (n = 10) and KIR-100 (n = 10) groups received an intraperitoneal injection of Kineret® at doses of 50 and 100 mg/kg, respectively. IRG and SOC (n = 10) rat groups were given distilled water as solvent using the same method...
August 24, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27537510/inducing-metabolic-suppression-in-severe-hemorrhagic-shock-pilot-study-results-from-the-biochronicity-project
#20
George E Black, Kyle K Sokol, Robert R Shawhan, Matthew J Eckert, Shashikumar Salgar, Shannon T Marko, Zachary S Hoffer, Christopher C Keyes, Mark B Roth, Matthew J Martin
BACKGROUND: Suspended animation-like states have been achieved in small animal models, but not in larger species. Inducing metabolic suppression and temporary oxygen independence could enhance survivability of massive injury. Based on prior analyses of key pathways, we hypothesized that phosphoinositol-3-kinase inhibition would produce metabolic suppression without worsening organ injury or systemic physiology. METHODS: Twenty swine were studied using LY294002 (LY), a nonselective phosphoinositol-3-kinase inhibitor...
December 2016: Journal of Trauma and Acute Care Surgery
keyword
keyword
101875
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"