keyword
https://read.qxmd.com/read/38541089/urinary-post-translationally-modified-fetuin-a-uptm-feta-in-chronic-kidney-disease-patients-with-and-without-diabetic-kidney-disease
#21
JOURNAL ARTICLE
Michela Musolino, Marta Greco, Mario D'Agostino, Loredana Tripodi, Roberta Misiti, Francesco Dragone, Paola Cianfrone, Mariateresa Zicarelli, Daniela Patrizia Foti, Michele Andreucci, Davide Bolignano, Giuseppe Coppolino
Background and Objectives: A novel post-translational modification (PTM) fragment derived from the cleavage of Fetuin-A (PTM-FetA) has recently emerged as a sensitive biomarker for kidney damage in diabetic patients, but evidence in other chronic renal diseases is lacking. In this pilot study, we aimed at evaluating the clinical significance of urinary PTM-FetA (uPTM-FetA) in a mixed cohort of patients with non-advanced chronic kidney disease (CKD) secondary to diabetic kidney disease (DKD) or other causes...
February 21, 2024: Medicina
https://read.qxmd.com/read/38541041/the-role-of-the-l-arginine-nitric-oxide-molecular-pathway-in-autosomal-dominant-polycystic-kidney-disease
#22
JOURNAL ARTICLE
Corina Daniela Ene, Mircea Penescu, Ilinca Nicolae, Cristina Capusa
Recently, arginine has been proven to play an important role in ADPKD physiopathology. Arginine auxotrophy in ADPKD induces cell hyperproliferation, blocking the normal differentiation of renal tube cells and causing cyst formation. We explored the L-arginine (Arg)-nitric oxide (NO) molecular pathway in ADPKD, a multisystemic arginine auxotrophe disease. We developed a prospective case-control study that included a group of 62 ADPKD subjects with an estimated filtration rate over 60 mL/min/1.73 mp, 26 subjects with chronic kidney disease with an eGFR > 60 mL/min/1...
March 11, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38540913/postbiotic-of-pediococcus-acidilactici-gq01-a-novel-probiotic-strain-isolated-from-natural-fermented-wolfberry-attenuates-hyperuricaemia-in-mice-through-modulating-uric-acid-metabolism-and-gut-microbiota
#23
JOURNAL ARTICLE
Lu Ren, Shangshang Wang, Shiting Liu, Hetti Arachchige Chalani Prasanthi, Yuechan Li, Jun Cao, Feiliang Zhong, Le Guo, Fuping Lu, Xuegang Luo
Hyperuricaemia (HUA) is a disorder of purine metabolism, which manifests itself as an increase in uric acid production and a decrease in uric acid excretion, as well as a change in the structure of the intestinal microbiota. Most of the drugs currently used to treat HUA have significant side effects, and it is essential to find a treatment for HUA that is free of side effects. In this study, a novel strain, Pediococcus acidilactici GQ01, was screened from natural fermented wolfberry. The effects of both live bacteria GQ01 and its heat-killed G1PB postbiotic on HUA were investigated...
March 18, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38540830/ethanol-extracts-from-torreya-grandis-seed-have-potential-to-reduce-hyperuricemia-in-mouse-models-by-influencing-purine-metabolism
#24
JOURNAL ARTICLE
Jianghui Yao, Enhe Bai, Yanwen Duan, Yong Huang
The purpose of this study was to evaluate the efficacy of ethanol extracts from Torreya grandis seed (EST) as a functional food in hyperuricemia mice. We investigated EST by analyzing its chemical composition. Using a mouse model of hyperuricemia induced by potassium oxonate (PO), we evaluated the effects of EST on uric acid (UA) production, inflammation-related cytokines, and gut microbiota diversity. The primary constituents of EST consist of various flavonoids and phenolic compounds known for their antioxidant and anti-inflammatory properties in vitro...
March 9, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38540735/the-role-of-muc1-in-renal-cell-carcinoma
#25
REVIEW
Martina Milella, Monica Rutigliano, Francesco Lasorsa, Matteo Ferro, Roberto Bianchi, Giuseppe Fallara, Felice Crocetto, Savio Domenico Pandolfo, Biagio Barone, Antonio d'Amati, Marco Spilotros, Michele Battaglia, Pasquale Ditonno, Giuseppe Lucarelli
Mucins are a family of high-molecular-weight glycoproteins. MUC1 is widely studied for its role in distinct types of cancers. In many human epithelial malignancies, MUC1 is frequently overexpressed, and its intracellular activities are crucial for cell biology. MUC1 overexpression can enhance cancer cell proliferation by modulating cell metabolism. When epithelial cells lose their tight connections, due to the loss of polarity, the mucins become dispersed on both sides of the epithelial membrane, leading to an abnormal mucin interactome with the membrane...
March 7, 2024: Biomolecules
https://read.qxmd.com/read/38540270/transforming-diabetes-care-the-molecular-pathways-through-which-glp1-ras-impact-the-kidneys-in-diabetic-kidney-disease
#26
REVIEW
Merita Rroji, Goce Spasovski
Diabetic kidney disease (DKD) is a substantial complication of type 2 diabetes (T2D), presenting challenges in chronic kidney disease (CKD) management. In addition to traditional and recent therapies, including angiotensin, converting enzyme (ACE) inhibitors, angiotensin receptor blockers, sodium-glucose cotransporter 2 (SGLT2) inhibitors, and mineralocorticoid receptor antagonists, the evolution of antihyperglycemic treatments has introduced a promising agent, glucagon-like peptide-1 receptor agonist (GLP-1RA) for the management of DKD...
March 14, 2024: Biomedicines
https://read.qxmd.com/read/38540220/uremic-toxins-and-inflammation-metabolic-pathways-affected-in-non-dialysis-dependent-stage-5-chronic-kidney-disease
#27
JOURNAL ARTICLE
María Peris-Fernández, Marta Roca-Marugán, Julià L Amengual, Ángel Balaguer-Timor, Iris Viejo-Boyano, Amparo Soldevila-Orient, Ramon Devesa-Such, Pilar Sánchez-Pérez, Julio Hernández-Jaras
Chronic kidney disease (CKD) affects approximately 12% of the global population, posing a significant health threat. Inflammation plays a crucial role in the uremic phenotype of non-dialysis-dependent (NDD) stage 5 CKD, contributing to elevated cardiovascular and overall mortality in affected individuals. This study aimed to explore novel metabolic pathways in this population using semi-targeted metabolomics, which allowed us to quantify numerous metabolites with known identities before data acquisition through an in-house polar compound library...
March 7, 2024: Biomedicines
https://read.qxmd.com/read/38540134/metabolomic-profiling-of-mice-with-tacrolimus-induced-nephrotoxicity-carnitine-deficiency-in-renal-tissue
#28
JOURNAL ARTICLE
Sho Nishida, Tamaki Ishima, Natsuka Kimura, Daiki Iwami, Ryozo Nagai, Yasushi Imai, Kenichi Aizawa
Tacrolimus (TAC)-induced chronic nephrotoxicity (TAC nephrotoxicity) has a detrimental effect on long-term kidney graft survival. However, the pathogenesis of TAC nephrotoxicity remains largely unknown. We explored it by focusing on metabolic changes in renal tissues. In this study, mice were separated into TAC and control groups (n = 5/group). TAC was administered to the TAC group (1 mg/kg/d for 28 days) subcutaneously. The control group was similarly treated with normal saline. Renal tissue metabolomes were evaluated...
February 26, 2024: Biomedicines
https://read.qxmd.com/read/38539987/nutrient-composition-and-feed-hygiene-of-alfalfa-comparison-of-feed-intake-and-selected-metabolic-parameters-in-horses-fed-alfalfa-haylage-alfalfa-hay-or-meadow-hay
#29
JOURNAL ARTICLE
Marlene Köninger, Astrid von Velsen-Zerweck, Carolin Eiberger, Christof Löffler, Anja Töpper, Christian Visscher, Bernd Reckels, Ingrid Vervuert
The aim of this study was to examine the nutrient composition and feed hygiene of alfalfa as well as investigate the feed intake, blood, urine and faecal parameters of horses fed alfalfa haylage (AS) compared with alfalfa hay (AH) and meadow hay (MH). A total of 11 geldings were fed ad libitum (2.1% dry matter (DM) of body weight (BW)) with alfalfa haylage, alfalfa hay and meadow hay (MH) in a Latin square design. On days 0 and 21 of the feeding period, blood samples were analysed for kidney and liver parameters...
March 13, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38539867/beyond-mortality-exploring-the-influence-of-plant-phenolics-on-modulating-ferroptosis-a-systematic-review
#30
REVIEW
Nemanja Živanović, Marija Lesjak, Nataša Simin, Surjit K S Srai
Ferroptosis is a recently discovered type of programmed cell death that is mechanistically different from other types of programmed cell death such as apoptosis, necroptosis, and autophagy. It is characterized by the accumulation of intracellular iron, overproduction of reactive oxygen species, depletion of glutathione, and extensive lipid peroxidation of lipids in the cell membrane. It was discovered that ferroptosis is interconnected with many diseases, such as neurodegenerative diseases, ischemia/reperfusion injury, cancer, and chronic kidney disease...
March 10, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38539832/antioxidant-systems-as-modulators-of-ferroptosis-focus-on-transcription-factors
#31
REVIEW
Carolina Punziano, Silvia Trombetti, Elena Cesaro, Michela Grosso, Raffaella Faraonio
Ferroptosis is a type of programmed cell death that differs from apoptosis, autophagy, and necrosis and is related to several physio-pathological processes, including tumorigenesis, neurodegeneration, senescence, blood diseases, kidney disorders, and ischemia-reperfusion injuries. Ferroptosis is linked to iron accumulation, eliciting dysfunction of antioxidant systems, which favor the production of lipid peroxides, cell membrane damage, and ultimately, cell death. Thus, signaling pathways evoking ferroptosis are strongly associated with those protecting cells against iron excess and/or lipid-derived ROS...
February 28, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38539672/effects-of-a-diabetic-microenvironment-on-neurodegeneration-special-focus-on-neurological-cells
#32
REVIEW
Vishal Chavda, Dhananjay Yadav, Snehal Patel, Minseok Song
Diabetes is a chronic metabolic condition associated with high levels of blood glucose which leads to serious damage to the heart, kidney, eyes, and nerves. Elevated blood glucose levels damage brain function and cognitive abilities. They also lead to various neurological and neuropsychiatric disorders, including chronic neurodegeneration and cognitive decline. High neuronal glucose levels can cause drastic neuronal damage due to glucose neurotoxicity. Astrocytes, a type of glial cell, play a vital role in maintaining brain glucose levels through neuron-astrocyte coupling...
March 15, 2024: Brain Sciences
https://read.qxmd.com/read/38538743/prefeeding-of-clarias-gariepinus-with-spirulina-platensis-counteracts-petroleum-hydrocarbons-induced-hepato-and-nephrotoxicity
#33
JOURNAL ARTICLE
Alaa El-Din H Sayed, Nasser S Abou Khalil, Alshaimaa A I Alghriany, Sary Kh Abdel-Ghaffar, Asmaa A A Hussein
Petroleum aromatic hydrocarbons are considered one of the most dangerous aquatic pollutants due to their widespread across water bodies, persistence, and extension to the food chain. To our knowledge, there hasn't been any research investigating the hepatorenoprotective effects of Spirulina platensis (SP) against toxicity induced by these environmental toxicants in fish. Thus, we decided to explore its potential safeguarding against benzene and toluene exposure in adult Clarias gariepinus. To achieve this objective, fish were divided into five groups (60 per group; 20 per replicate)...
March 27, 2024: Scientific Reports
https://read.qxmd.com/read/38538618/community-pharmacist-led-point-of-care-egfr-screening-early-detection-of-chronic-kidney-disease-in-high-risk-patients
#34
JOURNAL ARTICLE
Ammar Abdulrahman Jairoun, Sabaa Saleh Al-Hemyari, Moyad Shahwan, Samer H Zyoud, Faris El-Dahiyat
Adherence to scheduled physician screenings for renal function monitoring in patients with chronic kidney disease (CKD) or those at high risk remains suboptimal despite the endorsement of regular screenings by several clinical practice guidelines. Our study aims to assess the effectiveness of a point-of-care CKD screening program led by these pharmacists using the PICCOLO device while recognizing the unique position of community pharmacists in primary care. We conducted an 11-month prospective point-of-care interventional research study in the United Arab Emirates to evaluate the performance of a community pharmacist-led CKD screening program for high-risk patients...
March 27, 2024: Scientific Reports
https://read.qxmd.com/read/38538617/multi-organ-single-cell-transcriptomics-of-immune-cells-uncovered-organ-specific-gene-expression-and-functions
#35
JOURNAL ARTICLE
Maria Tsagiopoulou, Sonal Rashmi, Sergio Aguilar-Fernandez, Juan Nieto, Ivo G Gut
Despite the wealth of publicly available single-cell datasets, our understanding of distinct resident immune cells and their unique features in diverse human organs remains limited. To address this, we compiled a meta-analysis dataset of 114,275 CD45+ immune cells sourced from 14 organs in healthy donors. While the transcriptome of immune cells remains relatively consistent across organs, our analysis has unveiled organ-specific gene expression differences (GTPX3 in kidney, DNTT and ACVR2B in thymus). These alterations are linked to different transcriptional factor activities and pathways including metabolism...
March 27, 2024: Scientific Data
https://read.qxmd.com/read/38538321/comprehensive-analysis-of-cuproptosis-related-genes-in-immune-infiltration-and-development-of-a-novel-diagnostic-model-for-acute-kidney-injury
#36
JOURNAL ARTICLE
Yajing Li, Yingxue Ding
BACKGROUND: Acute kidney injury (AKI) represents a diverse range of conditions characterized by high incidence and mortality rates, and it is mainly associated with immune-mediated mechanisms and mitochondrial metabolism dysfunction. Cuproptosis, a recently identified form of programmed cell death dependent on copper, is closely linked to mitochondrial respiration and contributes to various diseases. Our study aimed to investigate the involvement of cuproptosis-related genes (CRGs) in AKI...
December 2024: Renal Failure
https://read.qxmd.com/read/38537887/analyzing-chemical-composition-of-sargentodoxae-caulis-water-extract-and-their-hypouricemia-effect-in-hyperuricemic-mice
#37
JOURNAL ARTICLE
Wen-Wen Liu, Hong-Jing Dong, Zhe Zhang, Xin-Hui Ma, Shuang Liu, Wei Huang, Xiao Wang
Hyperuricemia (HUA) is a metabolic disease characterized by the increase of serum uric acid (UA) level. Sargentodoxae Caulis (SC) is a commonly used herbal medicine for the treatment of gouty arthritis, traumatic swelling, and rheumatic arthritis in clinic. In this study, a total of fifteen compounds were identified in SC water extract using UHPLC-Q-TOF-MS/MS, including three phenolic acids, seven phenolic glycosides, four organic acids, and one lignan. Then, to study the hypouricemia effect of SC, a HUA mouse model was induced using a combination of PO, HX, and 20% yeast feed...
March 25, 2024: Fitoterapia
https://read.qxmd.com/read/38537484/tacrolimus-intra-patient-variability-measures-and-its-associations-with-allograft-clinical-outcomes-in-kidney-transplantation
#38
REVIEW
Wenmin Xie, Shupan Fan, Ruolin Liu, Wencheng Yan, Chengxin Su, Kaile Zheng, Xuebin Wang, Zhuo Wang
AIMS: Tacrolimus (Tac) is commonly prescribed in solid organ transplantation to prevent immune-mediated damage to the graft. However, its pharmacokinetics show substantial variability between and within patients. Intra-patient variability of tacrolimus (Tac-IPV) has emerged as a novel marker to predict transplant outcomes. Numerous studies report varying associations between Tac-IPV and clinical outcomes, with Tac-IPV measures showing wide discrepancies among these studies. This inconsistency could be a significant factor that influences the various outcomes reported in different studies...
March 21, 2024: Transplantation Reviews
https://read.qxmd.com/read/38536547/increased-risk-of-nephrolithiasis-an-emerging-issue-in-children-with-congenital-adrenal-hyperplasia-due-to-21-hydroxylase-deficiency
#39
JOURNAL ARTICLE
Mariangela Chiarito, Crescenza Lattanzio, Vito D'Ascanio, Donatella Capalbo, Paolo Cavarzere, Anna Grandone, Francesca Aiello, Giorgia Pepe, Malgorzata Wasniewska, Thomas Zoller, Mariacarolina Salerno, Maria Felicia Faienza
PURPOSE: To investigate the incidence of nephrolithiasis in a cohort of children with congenital adrenal hyperplasia (CAH), and to study if there is an association with the metabolic control of the disease. METHODS: This study was designed as a multicenter 1 year-prospective study involving 52 subjects (35 males) with confirmed molecular diagnosis of CAH due to 21-hydroxylase deficiency (21-OHD). Each patient was evaluated at three different time-points: T0, T1 (+6 months of follow-up), T2 (+12 months of follow up)...
March 27, 2024: Endocrine
https://read.qxmd.com/read/38536010/hydrophobic-functionalization-of-a-metal-organic-framework-as-an-ammonia-visual-sensing-material-under-high-humidity-conditions
#40
JOURNAL ARTICLE
Yuxin Wang, Zhengxuan Song, Yutao Liu, Yang Chen, Jinping Li, Libo Li, Jia Yao
Since exhaled ammonia (NH3 ) is one of the metabolic markers of liver and kidney diseases, ammonia visual sensing materials in humid environments have received extensive attention and investigation. Herein, through a tailor-made pore environment provided by metal-organic framework (MOF) materials (CH3 -Cu(BDC)), we achieved NH3 anti-interference sensing with apparent color changing under humid conditions. With methyl (CH3 -) functionalization, CH3 -Cu(BDC) demonstrated a strong response for trace ammonia and showed high selectivity under a humid environment...
March 27, 2024: Dalton Transactions: An International Journal of Inorganic Chemistry
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