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JOURNAL ARTICLE
Doaa Nader, Mona Abdelmaseeh, Rania Al Sharif, Nermin Samir
This study intended to evaluate the diagnostic efficacy of serum interleukin-6 (IL-6) and serum expression level of microRNA 15a (miRNA 15a) in sepsis patients admitted to the medical intensive care unit (ICU), and to correlate the results with the outcome of patients. This observational case-control study, was done from January 2022 to June 2022, included 75 adult ICU patients ≥18 years old, divided into 2 groups. Group 1: included 38 adults, critically ill sepsis patients and Group 2 (control group), included 37 adults, non-sepsis patients admitted to the ICU...
July 2023: Egyptian Journal of Immunology
#22
JOURNAL ARTICLE
Wei Peng, Yun Yang, Jiaquan Chen, Zeyao Xu, Yuanlei Lou, Qi Li, Ning Zhao, Kejian Qian, Fen Liu
BACKGROUND: Sepsis-induced acute lung injury is a common critical illness in intensive care units with no effective treatment is currently available. Small extracellular vesicles, secreted by mesenchymal stem cells (MSCs), derived from human-induced pluripotent stem cells (iMSC-sEV), possess striking advantages when incorporated MSCs and iPSCs, which are considered extremely promising cell-free therapeutic agents. However, no studies have yet been conducted to systemically examine the effects and underlying mechanisms of iMSC-sEV application on attenuated lung injury under sepsis conditions...
2023: Journal of Immunology Research
#23
REVIEW
Jianhua Zhang, Wanyi Tian, Fang Wang, Jiao Liu, Jiang Huang, Suwit Duangmano, Hao Liu, Minghua Liu, Zhuo Zhang, Xian Jiang
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a critical and life-threatening illness that causes severe dyspnea, and respiratory distress and is often caused by a variety of direct or indirect factors that damage the alveolar epithelium and capillary endothelial cells, leading to inflammation factors and macrophage infiltration. Macrophages play a crucial role in the progression of ALI/ARDS, exhibiting different polarized forms at different stages of the disease that control the disease outcome...
July 6, 2023: Cell Cycle
#24
JOURNAL ARTICLE
R Keikha, S M Hashemi-Shahri, A Jebali
INTRODUCTION: The expression of specific miRNAs and their mRNA targets are changed in infectious disease. The aim of this study was to analyze the expression of pro-neuroinflammatory miRNAs, anti-neuroinflammatory miRNAs, and their mRNA targets in the serum of COVID-19 patients with different grades. METHODS: COVID-19 patients with different grades were enrolled in this study and the expression of pro-neuroinflammatory miRNAs, anti-neuroinflammatory miRNAs, and their target mRNAs was analyzed by q-PCR...
2023: Neurología
#25
JOURNAL ARTICLE
David de Gonzalo-Calvo, Marta Molinero, Iván D Benítez, Manel Perez-Pons, Nadia García-Mateo, Alicia Ortega, Tamara Postigo, María C García-Hidalgo, Thalia Belmonte, Carlos Rodríguez-Muñoz, Jessica González, Gerard Torres, Clara Gort-Paniello, Anna Moncusí-Moix, Ángel Estella, Luis Tamayo Lomas, Amalia Martínez de la Gándara, Lorenzo Socias, Yhivian Peñasco, Maria Del Carmen de la Torre, Elena Bustamante-Munguira, Elena Gallego Curto, Ignacio Martínez Varela, María Cruz Martin Delgado, Pablo Vidal-Cortés, Juan López Messa, Felipe Pérez-García, Jesús Caballero, José M Añón, Ana Loza-Vázquez, Nieves Carbonell, Judith Marin-Corral, Ruth Noemí Jorge García, Carmen Barberà, Adrián Ceccato, Laia Fernández-Barat, Ricard Ferrer, Dario Garcia-Gasulla, Jose Ángel Lorente-Balanza, Rosario Menéndez, Ana Motos, Oscar Peñuelas, Jordi Riera, Jesús F Bermejo-Martin, Antoni Torres, Ferran Barbé
BACKGROUND: The identification of critically ill COVID-19 patients at risk of fatal outcomes remains a challenge. Here, we first validated candidate microRNAs (miRNAs) as biomarkers for clinical decision-making in critically ill patients. Second, we constructed a blood miRNA classifier for the early prediction of adverse outcomes in the ICU. METHODS: This was a multicenter, observational and retrospective/prospective study including 503 critically ill patients admitted to the ICU from 19 hospitals...
June 17, 2023: Respiratory Research
#26
JOURNAL ARTICLE
Peiyu Li, Tao Li, Zhiming Zhang, Xingui Dai, Bin Zeng, Zhen Li, Zhiwang Li
Background Severe coronavirus disease 2019 (COVID -19) has led to severe pneumonia or acute respiratory distress syndrome (ARDS) worldwide. we have noted that many critically ill patients with COVID-19 present with typical sepsis-related clinical manifestations, including multiple organ dysfunction syndrome, coagulopathy, and septic shock. The molecular mechanisms that underlie COVID-19, ARDS and sepsis are not well understood. The objectives of this study were to analyze potential molecular mechanisms and identify potential drugs for the treatment of COVID-19, ARDS and sepsis using bioinformatics and a systems biology approach...
2023: Frontiers in Immunology
#27
JOURNAL ARTICLE
Sarah J Ullrich, Nicholas K Yung, Tory J Bauer-Pisani, Nathan L Maassel, Mary Elizabeth Guerra, Mollie Freedman-Weiss, Samantha L Ahle, Adele S Ricciardi, Maor Sauler, W Mark Saltzman, Alexandra S Piotrowski-Daspit, David H Stitelman
Structural fetal diseases, such as congenital diaphragmatic hernia (CDH) can be diagnosed prenatally. Neonates with CDH are healthy in utero as gas exchange is managed by the placenta, but impaired lung function results in critical illness from the time a baby takes its first breath. MicroRNA (miR) 200b and its downstream targets in the TGF-β pathway are critically involved in lung branching morphogenesis. Here, we characterize the expression of miR200b and the TGF-β pathway at different gestational times using a rat model of CDH...
June 13, 2023: Molecular Therapy. Nucleic Acids
#28
REVIEW
Heng-Chang Zhang, Yang Du, Lei Chen, Zeng-Qiang Yuan, Yong Cheng
The three sets of symptoms associated with schizophrenia-positive, negative, and cognitive-are burdensome and have serious effects on public health, which affects up to 1% of the population. It is now commonly believed that in addition to the traditional dopaminergic mesolimbic pathway, the etiology of schizophrenia also includes neuronal networks, such as glutamate, GABA, serotonin, BDNF, oxidative stress, inflammation and the immune system. Small noncoding RNA molecules called microRNAs (miRNAs) have come to light as possible participants in the pathophysiology of schizophrenia in recent years by having an impact on these systems...
January 24, 2023: Neuroscience and Biobehavioral Reviews
#29
REVIEW
Zhengye Tan, Wen Li, Xiang Cheng, Qing Zhu, Xinhua Zhang
Non-coding RNAs (ncRNAs), including miRNAs, lncRNAs, circRNAs, and piRNAs, do not encode proteins. Nonetheless, they have critical roles in a variety of cellular activities-such as development, neurogenesis, degeneration, and the response to injury to the nervous system-via protein translation, RNA splicing, gene activation, silencing, modifications, and editing; thus, they may serve as potential targets for disease treatment. The activity of adult neural stem cells (NSCs) in the subgranular zone of the hippocampal dentate gyrus critically influences hippocampal function, including learning, memory, and emotion...
December 22, 2022: Biomolecules
#30
REVIEW
Esteban G Figueroa, Aitor Caballero-Román, Josep R Ticó, Montserrat Miñarro, Anna Nardi-Ricart, Alejandro González-Candia
Central nervous system (CNS)-related diseases are difficult to treat as most therapeutic agents they cannot reach the brain tissue, mainly due to the blood-brain barrier (BBB), arguably the tightest barrier between the human body and cerebral parenchyma, which routinely excludes most xenobiotic therapeutics compounds. The BBB is a multicellular complex that structurally forms the neurovascular unit (NVU) and is organized by neuro-endothelial and glial cells. BBB breakdown and dysfunction from the cerebrovascular cells lead to leakages of systemic components from the blood into the CNS, contributing to neurological deficits...
2022: Curr Res Pharmacol Drug Discov
#31
JOURNAL ARTICLE
Qi Zhang, Bishuang Chen, Ping Yang, Jipan Wu, Xinping Pang, Chaoyang Pang
Alzheimer's disease (AD) is a progressive neurological disease that worsens with time. The hallmark illnesses include extracellular senile plaques caused by β-amyloid protein deposition, neurofibrillary tangles caused by tau protein hyperphosphorylation, and neuronal loss accompanying glial cell hyperplasia. Noncoding RNAs are substantially implicated in related pathophysiology, according to mounting data. However, the function of these ncRNAs is mainly unclear. Circular RNAs (circRNAs) include many miRNA-binding sites (miRNA response elements, MREs), which operate as miRNA sponges or competing endogenous RNAs (ceRNAs)...
2022: Frontiers in Genetics
#32
JOURNAL ARTICLE
Wadad El Khatib, Mirna Fawaz, Mohammad N Al-Shloul, Ahmad Rayan, Mohammed ALBashtawy, Rasmieh M Al-Amer, Asem Abdalrahim, Moawiah Khatatbeh
Introduction: A loved one's hospitalization in a critical care unit is a traumatic experience for families. However, because of their status and professional competence, a family member who is also a critical care nurse has additional obstacles and often long-term consequences. Objectives: To describe the experiences of critical care nurse-family members when a loved one is admitted to a critical care unit at the Hotel-Dieu de France hospital. Methods: A qualitative path based on van Manen's hermeneutic phenomenology combining both descriptive and interpretive models were adopted...
January 2022: SAGE Open Nursing
#33
JOURNAL ARTICLE
Cheng-Shyuan Rau, Pao-Jen Kuo, Hui-Ping Lin, Chia-Jung Wu, Yi-Chan Wu, Peng-Chen Chien, Ting-Min Hsieh, Hang-Tsung Liu, Chun-Ying Huang, Ching-Hua Hsieh
Purpose: Following major trauma, genes involved in adaptive immunity are downregulated, which accompanies the upregulation of genes involved in systemic inflammatory responses. This study investigated microRNA (miRNA)-mRNA interactome dysregulation in circulating T cells of patients with major trauma. Patients and Methods: This study included adult trauma patients who had an injury severity score ≥16 and required ventilator support for more than 48 h in the intensive care unit...
2022: Journal of Inflammation Research
#34
JOURNAL ARTICLE
Jieqiong Wang, Ming Chen, Weihua Xu, Lu Shou, Xiaosheng Jin, Xianrong Xu, Feihua Huang
Objective: Acute lung injury (ALI) is a severe respiratory disorder causing alveolar-capillary barrier, leading to a high rate of morbidity and death in critically ill individuals. microRNAs (miRNAs)-mediated mechanism in the pathogenesis of ALI has attracted much interest. Herein, we attempt to characterize a candidate miRNA and its downstream target that is linked to the pathogenesis of ALI. Methods: LPS-conditioned MH-S cells were treated with miR-29a-1-5p mimic, inhibitor, and RNT4 expression vector, and the ALI animal model was injected with agomir and antagomir of miR-29b-1-5p and RNT4 expression vector, in which the pro-inflammatory cytokine production, cell viability and apoptosis, myeloperoxidase (MPO) activity, wet/dry (W/D) ratio, and expression of TGF- β 1, α -smooth muscle actin ( α -SMA), E-cadherin, and vimentin were examined...
2022: Evidence-based Complementary and Alternative Medicine: ECAM
#35
JOURNAL ARTICLE
Cecilia López-Martínez, Paula Martín-Vicente, Juan Gómez de Oña, Inés López-Alonso, Helena Gil-Peña, Elías Cuesta-Llavona, Margarita Fernández-Rodríguez, Irene Crespo, Estefanía Salgado Del Riego, Raquel Rodríguez-García, Diego Parra, Javier Fernández, Javier Rodríguez-Carrio, Francisco José Jimeno-Demuth, Alberto Dávalos, Luis A Chapado, Eliecer Coto, Guillermo M Albaiceta, Laura Amado-Rodríguez
Infections caused by SARS-CoV-2 may cause a severe disease, termed COVID-19, with significant mortality. Host responses to this infection, mainly in terms of systemic inflammation, have emerged as key pathogenetic mechanisms, and their modulation has shown a mortality benefit.In a cohort of 56 critically-ill COVID-19 patients, peripheral blood transcriptomes were obtained at admission in an Intensive Care Unit (ICU) and clustered using an unsupervised algorithm. Differences in gene expression, circulating microRNAs (c-miRNA) and clinical data between clusters were assessed, and circulating cell populations estimated from sequencing data...
September 14, 2022: European Respiratory Journal
#36
JOURNAL ARTICLE
Denis J Ohlstrom, Christina Sul, Christine U Vohwinkel, Laura Hernandez-Lagunas, Anis Karimpour-Fard, Peter M Mourani, Todd C Carpenter, Eva S Nozik, Carmen C Sucharov
Acute respiratory distress syndrome is a heterogeneous pathophysiological process responsible for significant morbidity and mortality in pediatric intensive care patients. Diagnosis is defined by clinical characteristics that identify the syndrome after development. Subphenotyping patients at risk of progression to ARDS could provide the opportunity for therapeutic intervention. microRNAs, non-coding RNAs stable in circulation, are a promising biomarker candidate. We conducted a single-center prospective cohort study to evaluate random forest classification of microarray-quantified circulating microRNAs in critically ill pediatric patients...
August 26, 2022: Scientific Reports
#37
REVIEW
Nikolaos Antonakos, Charly Gilbert, Charlotte Théroude, Irene T Schrijver, Thierry Roger
Sepsis is a clinical syndrome defined as a dysregulated host response to infection resulting in life-threatening organ dysfunction. Sepsis is a major public health concern associated with one in five deaths worldwide. Sepsis is characterized by unbalanced inflammation and profound and sustained immunosuppression, increasing patient susceptibility to secondary infections and mortality. microRNAs (miRNAs) play a central role in the control of many biological processes, and deregulation of their expression has been linked to the development of oncological, cardiovascular, neurodegenerative and metabolic diseases...
2022: Frontiers in Immunology
#38
JOURNAL ARTICLE
Asuman Gedikbasi, Gokhan Adas, Nilgun Isiksacan, Kadriye Kart Yasar, Esra Canbolat Unlu, Rabia Yilmaz, Gulsum Oya Hergunsel, Zafer Cukurova
The epigenetic features contribute to variations in host susceptibility to SARS-CoV-2 infection and severity of symptoms. This study aimed to evaluate the relationship between the relative expression of microRNAs (miRNAs) and the severity of the disease in COVID-19 patients. The miRNA profiles were monitored during the different stages of the disease course using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The expression levels of the selected 11 miRNAs were measured in the blood samples collected from 73 patients (moderate, n = 37; severe, n = 25; critically ill, n = 11, a total of 219 longitudinal samples) on hospitalization day and days 7 and 21...
June 25, 2022: Genes
#39
JOURNAL ARTICLE
Yuki Togami, Hisatake Matsumoto, Jumpei Yoshimura, Tsunehiro Matsubara, Takeshi Ebihara, Hiroshi Matsuura, Yumi Mitsuyama, Takashi Kojima, Masakazu Ishikawa, Fuminori Sugihara, Haruhiko Hirata, Daisuke Okuzaki, Hiroshi Ogura
We evaluated mRNA and miRNA in COVID-19 patients and elucidated the pathogenesis of COVID-19 including protein profiles following mRNA and miRNA integration analysis. mRNA and miRNA sequencing was done on admission with whole blood of 5 and 16 healthy controls (HC) and 10 and 31 critically ill COVID-19 patients (derivation and validation cohorts, respectively). Interferon (IFN)-α2, IFN-β, IFN-γ, interleukin-27, and IFN-λ1 were measured in COVID-19 patients on admission (day 1, 181 critical/22 non-critical patients) and days 6-8 (168 critical patients) and in 19 HC...
July 13, 2022: Molecular Therapy. Nucleic Acids
#40
REVIEW
Mamta Panda, Elora Kalita, Satyendra Singh, Ketan Kumar, Abhishek Rao, Vijay Kumar Prajapati
COVID-19 is a highly transmissible disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), affects 226 countries and continents, and has resulted in >6.2 million deaths worldwide. Despite the efforts of all scientific institutions worldwide to identify potential therapeutics, no specific drug has been approved by the FDA to treat the COVID-19 patient. SARS-CoV-2 variants of concerns make the potential of publicly known therapeutics to respond to and detect disease onset highly improbable...
September 15, 2022: Life Sciences
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