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miRNA critical illness

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https://www.readbyqxmd.com/read/27897405/premorbid-obesity-but-not-nutrition-prevents-critical-illness-induced-muscle-wasting-and-weakness
#1
Chloë Goossens, Mirna Bastos Marques, Sarah Derde, Sarah Vander Perre, Thomas Dufour, Steven E Thiessen, Fabian Güiza, Thomas Janssens, Greet Hermans, Ilse Vanhorebeek, Katrien De Bock, Greet Van den Berghe, Lies Langouche
BACKGROUND: The 'obesity paradox' of critical illness refers to better survival with a higher body mass index. We hypothesized that fat mobilized from excess adipose tissue during critical illness provides energy more efficiently than exogenous macronutrients and could prevent lean tissue wasting. METHODS: In lean and premorbidly obese mice, the effect of 5 days of sepsis-induced critical illness on body weight and composition, muscle wasting, and weakness was assessed, each with fasting and parenteral feeding...
July 20, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27855391/suppression-of-microrna-219-5p-activates-keratinocyte-growth-factor-to-mitigate-severity-of-experimental-cirrhosis
#2
Li Chen, Xiang Cui, Peng Li, Cong Feng, Lili Wang, Hao Wang, Xuan Zhou, Bo Yang, Faqin Lv, Tanshi Li
BACKGROUND/AIMS: Keratinocyte growth factor (KGF) plays a critical role in prevention of cirrhosis and enhancement of liver regeneration. However, the molecular regulation of KGF in liver is unknown. MicroRNAs (miRNAs) control the pathogenesis of cirrhosis, whereas the exact involved miRNAs and molecular signaling pathways remain ill-defined. Here we addressed these questions. METHODS: We examined the correlation of the levels of miR-219-5p and KGF in the liver biopsies from patients with liver diseases...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27620842/mir-137-an-important-player-in-neural-development-and-neoplastic-transformation
#3
E Mahmoudi, M J Cairns
MicroRNAs (miRNAs) represent an important class of small regulatory RNAs that control gene expression posttranscriptionally by targeting mRNAs for degradation or translation inhibition. Early studies have revealed a complex role for miRNAs in major biological processes such as development, differentiation, growth and metabolism. MiR-137 in particular, has been of great interest due to its critical role in brain function and putative involvement in the etiology of both neuropsychiatric disorders and cancer. Several lines of evidence suggest that development, differentiation and maturation of the nervous system is strongly linked to the expression of miR-137 and its regulation of a large number of downstream target genes in various pathways...
September 13, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27612681/the-use-of-exosomes-as-biomarkers-for-evaluating-and-monitoring-critically-ill-polytrauma-patients-with-sepsis
#4
Marian Ticlea, Lavinia Melania Bratu, Florian Bodog, Ovidiu Horea Bedreag, Alexandru Florin Rogobete, Zorin Petrisor Crainiceanu
Regarding genetic biomarkers for early assessment and monitoring the clinical course in polytrauma patients with sepsis, in recent years a remarkable evolution has been highlighted. One of the main representatives is the exosome miRNAs. In this paper, we would like to present in more details the various methods of using exosome miRNAs as a biomarker for monitoring polytrauma patients with sepsis, as well as establishing a belated outcome by aggregating the entire clinical aspects. The use of exosome miRNAs for late evaluating and monitoring the clinical evolution of polytrauma patients can bring significant improvements in current clinical practice through the optimization and modulation of intensive care according to the needs of each patient individually...
September 9, 2016: Biochemical Genetics
https://www.readbyqxmd.com/read/27429052/plasma-biomarkers-to-study-mechanisms-of-liver-injury-in-patients-with-hypoxic-hepatitis
#5
James L Weemhoff, Benjamin L Woolbright, Rosalind E Jenkins, Mitchell R McGill, Matthew R Sharpe, Jody C Olson, Daniel J Antoine, Steven C Curry, Hartmut Jaeschke
BACKGROUND & AIMS: Hypoxic hepatitis is a clinical condition precipitated by prolonged periods of oxygen deprivation to the liver. It can have several underlying causes. Despite its prevalence in critically ill patients, which can reach upwards of 10%, very little is known about the mechanisms of injury. Thus, we set out to measure previously identified circulating biomarkers in an attempt to describe mechanisms of injury following hypoxic hepatitis. METHODS: Plasma from patients diagnosed with hypoxic hepatitis was collected for this study...
July 18, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27320175/circulating-plasma-micrornas-can-differentiate-human-sepsis-and-systemic-inflammatory-response-syndrome-sirs
#6
Stefano Caserta, Florian Kern, Jonathan Cohen, Stephen Drage, Sarah F Newbury, Martin J Llewelyn
Systemic inflammation in humans may be triggered by infection, termed sepsis, or non-infective processes, termed non-infective systemic inflammatory response syndrome (SIRS). MicroRNAs regulate cellular processes including inflammation and may be detected in blood. We aimed to establish definitive proof-of-principle that circulating microRNAs are differentially affected during sepsis and non-infective SIRS. Critically ill patients with severe (n = 21) or non-severe (n = 8) intra-abdominal sepsis; severe (n = 23) or non-severe (n = 21) non-infective SIRS; or no SIRS (n = 16) were studied...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27156313/the-use-of-circulating-mirnas-as-biomarkers-for-oxidative-stress-in-critically-ill-polytrauma-patients
#7
REVIEW
Ovidiu Horea Bedreag, Dorel Sandesc, Sorin Dan Chiriac, Alexandru Florin Rogobete, Alina Carmen Cradigati, Mirela Sarandan, Raluca Dumache, Radu Nartita, Marius Papurica
BACKGROUND: The diversity of primary and secondary traumatic injuries specific for the critically ill polytrauma patient is complicating the therapeutic management in the absence of a strict assessment of the biological changes. Inflammation, redox imbalance, and immunosuppression can be quantified by various biochemical parameters; however, they do not fully respond to the current requirements. Another phenomenon responsible for worsening the clinical status and for the development of complications in such patients is oxidative stress...
2016: Clinical Laboratory
https://www.readbyqxmd.com/read/27129188/down-regulation-of-mir-192-5p-protects-from-oxidative-stress-induced-acute-liver-injury
#8
Sanchari Roy, Fabian Benz, Jan Alder, Heike Bantel, Joern Janssen, Mihael Vucur, Jeremie Gautheron, Anne Schneider, Florian Schüller, Sven Loosen, Mark Luedde, Alexander Koch, Frank Tacke, Tom Luedde, Christian Trautwein, Christoph Roderburg
miR-192-5p has gained increasing relevance in various diseases, however, its function in acute liver injury is currently unknown. We analysed miR-192-5p serum levels and hepatic miR-192-5p expression in mice after hepatic ischaemia and reperfusion (I/R) as well as in toxic liver injury. On a functional level, miRNA levels were analysed in the different hepatic cell-compartments and in the context of tumour necrosis factor (TNF)-dependent liver cell death. We detected increased serum levels of miR-192-5p after hepatic I/R- and carbon tetrachloride (CCl4)-induced liver injury...
July 1, 2016: Clinical Science (1979-)
https://www.readbyqxmd.com/read/27008411/micrornas-regulate-host-immune-response-and-pathogenesis-during-influenza-infection-in-rhesus-macaques
#9
Andrea Rivera, Tasha Barr, Maham Rais, Flora Engelmann, Ilhem Messaoudi
microRNAs (miRNAs) are small noncoding RNAs that are key regulators of biological processes, including the immune response to viral infections. Differential expression levels of cellular miRNAs and their predicted targets have been described in the lungs of H1N1-infected BALB/c mice, the lungs of H5N1 influenza-infected cynomolgus macaques, and in peripheral blood mononuclear cells (PBMCs) of critically ill patients infected with 2009 pandemic H1N1. However, a longitudinal analysis of changes in the expression of miRNAs and their targets during influenza infection and how they relate to viral replication and host response has yet to be carried out...
May 2016: Viral Immunology
https://www.readbyqxmd.com/read/26825461/rbm3-regulates-temperature-sensitive-mir-142-5p-and-mir-143-thermomirs-which-target-immune-genes-and-control-fever
#10
Justin J-L Wong, Amy Y M Au, Dadi Gao, Natalia Pinello, Chau-To Kwok, Annora Thoeng, Katherine A Lau, Jane E A Gordon, Ulf Schmitz, Yue Feng, Trung V Nguyen, Robert Middleton, Charles G Bailey, Jeff Holst, John E J Rasko, William Ritchie
Fever is commonly used to diagnose disease and is consistently associated with increased mortality in critically ill patients. However, the molecular controls of elevated body temperature are poorly understood. We discovered that the expression of RNA-binding motif protein 3 (RBM3), known to respond to cold stress and to modulate microRNA (miRNA) expression, was reduced in 30 patients with fever, and in THP-1-derived macrophages maintained at a fever-like temperature (40 °C). Notably, RBM3 expression is reduced during fever whether or not infection is demonstrable...
April 7, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/26790856/microrna-regulation-of-acute-lung-injury-and-acute-respiratory-distress-syndrome
#11
REVIEW
Subbiah Rajasekaran, Dhamotharan Pattarayan, P Rajaguru, P S Sudhakar Gandhi, Rajesh K Thimmulappa
The acute respiratory distress syndrome (ARDS), a severe form of acute lung injury (ALI), is a very common condition associated with critically ill patients, which causes substantial morbidity and mortality worldwide. Despite decades of research, effective therapeutic strategies for clinical ALI/ARDS are not available. In recent years, microRNAs (miRNAs), small non-coding molecules have emerged as a major area of biomedical research as they post-transcriptionally regulate gene expression in diverse biological and pathological processes, including ALI/ARDS...
October 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/26784440/mesenchymal-stem-cells-alleviate-lps-induced-acute-lung-injury-in-mice-by-mir-142a-5p-controlled-pulmonary-endothelial-cell-autophagy
#12
Zichao Zhou, Zhijian You
BACKGROUND/AIMS: Damages of pulmonary endothelial cells (PECs) represent a critical pathological process during acute lung injury (ALI), and precede pulmonary epithelial cell injury, and long-term lung dysfunction. Transplantation of mesenchymal stem cells (MSCs) has proven therapeutic effects on ALI, whereas the underlying mechanisms remain ill-defined. METHOD: We transplanted MSCs in mice and then induced ALI using Lipopolysaccharides (LPS). We analyzed the changes in permeability index and lung histology...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/26761003/circulating-micrornas-as-biomarkers-for-sepsis
#13
REVIEW
Fabian Benz, Sanchari Roy, Christian Trautwein, Christoph Roderburg, Tom Luedde
Sepsis represents a major cause of lethality during intensive care unit (ICU) treatment. Pharmacological treatment strategies for sepsis are still limited and mainly based on the early initiation of antibiotic and supportive treatment. In this context, numerous clinical and serum based markers have been evaluated for the diagnosis, the severity, and the etiology of sepsis. However until now, few of these factors could be translated into clinical use. MicroRNAs (miRNAs) do not encode for proteins but regulate gene expression by inhibiting the translation or transcription of their target mRNAs...
January 9, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26586517/non-cultured-dermal-derived-mesenchymal-cells-attenuate-sepsis-induced-by-cecal-ligation-and-puncture-in-mice
#14
Yu Wang, Li Tan, Jie Jin, Huiqin Sun, Zelin Chen, Xu Tan, Yongping Su, Chunmeng Shi
Sepsis remains a threat to critically ill patients and carries a high morbidity and mortality. Cell-based therapies have risen in prominence in recent years. Dermal-derived mesenchymal cells (DMCs) are attractive as one of the abundant sources from which to isolate mesenchymal cells for therapeutic applications and can be easily accessed with minimal harm to the donor. In this study, we described for the first time the use of non-cultured DMCs for treating sepsis in a cecal ligation and puncture (CLP) mouse model and investigated their immunomodulatory effects...
November 20, 2015: Scientific Reports
https://www.readbyqxmd.com/read/26535690/microrna-29a-promotes-apoptosis-of-monocytes-by-targeting-stat3-during-sepsis
#15
X Song, C T Wang, X H Geng
Sepsis is a major cause of morbidity and mortality in critically ill patients. The sepsis syndrome results from a dysregulated inflammatory response to infection that leads to multiple-organ failure, but the underlying mechanisms remain poorly understood. More and more reports show that microRNAs (miRNAs) play an important role in sepsis. In the progression of this syndrome, cells change their behavior in response to cytokines stimulated by sepsis, such as interleukin-10 (IL-10). IL-10 can activate JAK2-STAT3 in the cells to protect them from damage...
2015: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/26525353/decreased-expression-of-mir-20a-and-mir-92a-in-the-serum-from-sulfur-mustard-exposed-patients-during-the-chronic-phase-of-resulting-illness
#16
Akbar Ghorbani Alvanegh, Houri Edalat, Parviz Fallah, Mahmood Tavallaei
CONTEXT: Sulfur mustard (SM), with extensive nucleophilic and alkylating properties, was employed during the Iran-Iraq war by Iraqi forces. The most critical complications attributed to SM are related to dangerous pulmonary disorders collectively known as "mustard lung". The symptoms gradually emerge over a long period, becoming chronic, and are dependent on time and the amount of exposed SM. Because of the unknown and complex nature of the disease, no differential diagnostic method or absolute treatment strategy has been formally developed...
2015: Inhalation Toxicology
https://www.readbyqxmd.com/read/26453334/role-of-mir-124-and-mir-141-in-the-regulation-of-vascular-reactivity-and-the-relationship-to-rhoa-and-rac1-after-hemorrhage-and-hypoxia
#17
Liangming Liu, Jiatao Zang, Xiangyun Chen, Guangming Yang, Yu Zhu, Yue Wu, Tao Li
Recent studies show that hypoxia can alter expression levels of microRNAs (miRNAs). Whether hypoxia or hemorrhage-induced vascular hyporeactivity is related to miRNAs and the underlying mechanisms of this process is not clear. Using hypoxia-treated superior mesenteric arteries (SMAs) and vascular smooth muscle cells (VSMCs) of rats that underwent hemorrhage, we observed the regulatory effects of miR-124/miR-141 on vascular reactivity, the relationship of these miRNAs to RhoA and Rac1, and the mutual regulation of miR-124 and miR-141...
January 15, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/26148929/circulating-levels-of-mir-150-are-associated-with-poorer-outcomes-of-a-h1n1-infection
#18
COMPARATIVE STUDY
Juan Morán, Gustavo Ramírez-Martínez, Luis Jiménez-Alvarez, Alfredo Cruz, Santiago Pérez-Patrigeon, Alfredo Hidalgo, Lorena Orozco, Angélica Martínez, Luis Padilla-Noriega, Federico Avila-Moreno, Carlos Cabello, Julio Granados, Blanca Ortíz-Quintero, Alejandra Ramírez-Venegas, Guillermo M Ruíz-Palacios, Albert Zlotnik, Enrique Merino, Joaquín Zúñiga
BACKGROUND: Overproduction of pro-inflammatory cytokines and chemokines is frequently associated with severe clinical manifestations in patients infected with influenza A/H1N1 virus. Micro-RNAs (miRNAs) are highly conserved small non-coding RNA molecules that post-transcriptionally regulate gene expression and are potential biomarkers and therapeutic targets in different inflammatory conditions. METHODS: We studied the circulating and miRNA profiles in critically ill A/H1N1 patients, A/H1N1 patients with milder disease, asymptomatic housemates and healthy controls...
October 2015: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/26051976/community-and-healthcare-associated-infections-in-critically-ill-patients-a-multicenter-cohort-study
#19
MULTICENTER STUDY
George Dabar, Carine Harmouche, Pascale Salameh, Bertrand L Jaber, Ghassan Jamaleddine, Mirna Waked, Patricia Yazbeck
OBJECTIVE: To compare the spectrum of infection, comorbidities, outcomes, and mortality of patients admitted to the intensive care unit (ICU) due to community-acquired or healthcare-associated severe sepsis. METHODS: This prospective cohort study was conducted in three university medical centers in Lebanon from February 2005 to December 2006. Patients with severe sepsis were included and followed up until hospital discharge or death. RESULTS: One hundred and twenty patients were included of whom 60% had community-acquired infections (CAI) and 40% had healthcare-associated infections (HAI)...
August 2015: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/26009823/neuropathological-correlates-of-hyperglycemia-during-prolonged-polymicrobial-sepsis-in-mice
#20
Romain Sonneville, Inge Derese, Mirna Bastos Marques, Lies Langouche, Sarah Derde, Laurent Chatre, Fabrice Chrétien, Djillali Annane, Tarek Sharshar, Greet Van den Berghe, Ilse Vanhorebeek
Glucose toxicity may play a crucial role in evoking neurologic complications of critical illness. We studied whether the neuropathological alterations in fatal human critical illness observed under hyperglycemia are present and can be attenuated by maintaining normoglycemia in a mouse model of prolonged sepsis induced by cecal ligation and puncture. Mice were randomized to moderate hyperglycemia (>8.3 mmol/L, n = 8) or normoglycemia (4.4-6.7 mmol/L, n = 8). After 5 days, hippocampus and frontal cortex from septic mice were compared with those from healthy controls (n = 8)...
September 2015: Shock
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