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https://www.readbyqxmd.com/read/28530462/using-yoga-nidra-to-improve-stress-in-psychiatric-nurses-in-a-pilot-study
#1
Roberta Anderson, Kristine Mammen, Padmini Paul, Allisyn Pletch, Kathleen Pulia
Given today's hurried and stressful heathcare system, nurses need mechanisms to take care of themselves, promote their own wellness, and build resilience in managing sick patients. Yoga is one such mechanism; it can decrease anxiety and improve sleep and quality of life. In this pilot study, nine nurses participated in 6 weekly sessions of yoga nidra. Measures of sleep, stress, and muscle fatigue were obtained to determine whether yoga had a positive impact upon quality of life and stress. Although based on a small sample of nurses, results indicated positive findings for both perceived stress level and muscle fatigue...
May 22, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28522152/anti-trypanosomal-activity-of-cationic-n-heterocyclic-carbene-gold-i-complexes
#2
Isabel Winter, Julia Lockhauserbäumer, Gertrud Lallinger-Kube, Rainer Schobert, Klaus Ersfeld, Bernhard Biersack
Two gold(I) N-heterocyclic carbene complexes 1a and 1b were tested for their anti-trypanosomal activity against Trypanosoma brucei parasites. Both gold compounds exhibited excellent anti-trypanosomal activity (IC50=0.9-3.0nM). The effects of the gold complexes 1a and 1b on the T. b. brucei cytoskeleton were evaluated. Rapid detachment of the flagellum from the cell body occurred after treatment with the gold complexes. In addition, a quick and complete degeneration of the parasitic cytoskeleton was induced by the gold complexes, only the microtubules of the detached flagellum remained intact...
May 15, 2017: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/28456523/the-canonical-poly-a-polymerase-pap1-polyadenylates-non-coding-rnas-and-is-essential-for-snorna-biogenesis-in-trypanosoma-brucei
#3
Vaibhav Chikne, Sachin Kumar Gupta, Tirza Doniger, K Shanmugha Rajan, Smadar Cohen-Chalamish, Hiba Waldman Ben-Asher, Liat Kolet, Nasreen Hag Yahia, Ron Unger, Elisabetta Ullu, Nikolay G Kolev, Christian Tschudi, Shulamit Michaeli
The parasite Trypanosoma brucei is the causative agent of African sleeping sickness and is known for its unique RNA processing mechanisms which are common to all the kinetoplastidea including Leishmania and Trypanosoma cruzi. Trypanosomes possess two canonical RNA poly (A) polymerases termed PAP1 and PAP2. PAP1 is encoded by one of the only two genes harboring cis-spliced introns in this organism and its function is currently unknown. In trypanosomes all mRNAs, as well as non-coding RNAs such as small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRNAs), undergo trans-splicing and polyadenylation...
April 26, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28453513/genetic-diversity-and-population-structure-of-the-tsetse-fly-glossina-fuscipes-fuscipes-diptera-glossinidae-in-northern-uganda-implications-for-vector-control
#4
Robert Opiro, Norah P Saarman, Richard Echodu, Elizabeth A Opiyo, Kirstin Dion, Alexis Halyard, Augustine W Dunn, Serap Aksoy, Adalgisa Caccone
Uganda is the only country where the chronic and acute forms of human African Trypanosomiasis (HAT) or sleeping sickness both occur and are separated by < 100 km in areas north of Lake Kyoga. In Uganda, Glossina fuscipes fuscipes is the main vector of the Trypanosoma parasites responsible for these diseases as well for the animal African Trypanosomiasis (AAT), or Nagana. We used highly polymorphic microsatellite loci and a mitochondrial DNA (mtDNA) marker to provide fine scale spatial resolution of genetic structure of G...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28449303/brief-intervention-physical-exercise-and-cognitive-behavioural-group-therapy-for-patients-with-chronic-low-back-pain-the-cins-trial
#5
A Harris, T F Moe, H R Eriksen, T Tangen, S A Lie, T H Tveito, S E Reme
BACKGROUND AND OBJECTIVE: Cognitive-behavioural treatments (CBT) and physical group exercise (PE) have both shown promising effects in reducing disability and increasing work participation among chronic low back pain (CLBP) patients. A brief cognitive intervention (BI) has previously been demonstrated to reduce work disability in CLBP. The aim of this study was to test if the effect of BI could be further increased by adding either group CBT or group PE. METHODS: A total of 214 patients, all sick listed 2-10 months due to CLBP, were randomized to BI (n = 99), BI + group CBT (n = 55) or BI + group PE (n = 60)...
April 27, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28426685/human-african-trypanosomiasis-control-achievements-and-challenges
#6
Serap Aksoy, Phillipe Buscher, Mike Lehane, Philippe Solano, Jan Van Den Abbeele
Sleeping sickness, also known as human African trypanosomiasis (HAT), is a neglected disease that impacts 70 million people living in 1.55 million km2 in sub-Saharan Africa. Since the beginning of the 20th century, there have been multiple HAT epidemics in sub-Saharan Africa, with the most recent epidemic in the 1990s resulting in about half a million HAT cases reported between 1990 and 2015. Here we review the status of HAT disease at the current time and the toolbox available for its control. We also highlight future opportunities under development towards novel or improved interventions...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28406895/the-superfamily-keeps-growing-identification-in-trypanosomatids-of-ribj-the-first-riboflavin-transporter-family-in-protists
#7
Darío E Balcazar, María Cristina Vanrell, Patricia S Romano, Claudio A Pereira, Fernando A Goldbaum, Hernán R Bonomi, Carolina Carrillo
BACKGROUND: Trypanosomatid parasites represent a major health issue affecting hundreds of million people worldwide, with clinical treatments that are partially effective and/or very toxic. They are responsible for serious human and plant diseases including Trypanosoma cruzi (Chagas disease), Trypanosoma brucei (Sleeping sickness), Leishmania spp. (Leishmaniasis), and Phytomonas spp. (phytoparasites). Both, animals and trypanosomatids lack the biosynthetic riboflavin (vitamin B2) pathway, the vital precursor of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) cofactors...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28397756/anti-trypanosomatid-elemanolide-sesquiterpene-lactones-from-vernonia-lasiopus-o-hoffm
#8
Njogu M Kimani, Josphat C Matasyoh, Marcel Kaiser, Reto Brun, Thomas J Schmidt
Sleeping sickness or human African trypanosomiasis (HAT) is a neglected tropical disease (NTD) threatening millions of peoples' lives with thousands infected. The disease is endemic in poorly developed regions of sub-Saharan Africa and is caused by the kinetoplastid "protozoan" parasite Trypanosoma brucei. The parasites are transmitted to humans through bites of infected tsetse flies of the genus Glossina. The few available drugs for treatment of this disease are highly toxic, difficult to administer, costly and unavailable to poor rural communities bearing the major burden of this infection...
April 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28391114/genotype-phenotype-dilemma-in-a-case-of-sudden-cardiac-death-with-the-e1053k-mutation-and-a-deletion-in-the-scn5a-gene
#9
T Jenewein, B M Beckmann, S Rose, H H Osterhues, U Schmidt, C Wolpert, P Miny, C Marschall, M Alders, C R Bezzina, A A M Wilde, S Kääb, S Kauferstein
Mutations in the cardiac sodium channel gene SCN5A may result in various arrhythmia syndromes such as long QT syndrome type 3 (LQTS), Brugada syndrome (BrS), sick sinus syndrome (SSS), cardiac conduction diseases (CCD) and possibly dilated cardiomyopathy (DCM). In most of these inherited cardiac arrhythmia syndromes the phenotypical expression may range from asymptomatic phenotypes to sudden cardiac death (SCD). A 16-year-old female died during sleep. Autopsy did not reveal any explanation for her death and a genetic analysis was performed...
March 20, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28373184/9-2-deoxy-2-fluoro-%C3%A3-d-arabinofuranosyl-adenine-a-potent-antitrypanosomal-adenosine-analogue-that-circumvents-transport-related-drug-resistance
#10
Farahnaz Ranjbarian, Munender Vodnala, Khalid J H Alzahrani, Godwin U Ebiloma, Harry P de Koning, Anders Hofer
Current chemotherapy against African sleeping sickness, a disease caused by the protozoan parasite Trypanosoma brucei, is limited by toxicity, inefficacy, and drug resistance. Nucleoside analogues have been successfully used to cure T. brucei-infected mice, but they all have the limitation of being taken up by the P2 nucleoside transporter, which, when mutated, is a common cause of multidrug resistance in T. brucei We report here that adenine arabinoside (Ara-A) and the newly tested drug 9-(2' -Deoxy-2' -fluoro-ß-D-arabinofuranosyl) adenine (FANA-A) are instead taken up by the P1 nucleoside transporter, which is not associated with drug resistance...
April 3, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28370590/normative-data-on-the-diurnal-pattern-of-the-karolinska-sleepiness-scale-ratings-and-its-relation-to-age-sex-work-stress-sleep-quality-and-sickness-absence-illness-in-a-large-sample-of-daytime-workers
#11
Torbjorn Åkerstedt, David Hallvig, Göran Kecklund
Self-rated sleepiness responds to sleep loss, time of day and work schedules. There is, however, a lack of a normative reference showing the diurnal pattern during a normal working day, compared with a day off, as well as differences depending on stress, sleep quality, sex, age and being sick listed. The present study sought to provide such data for the Karolinska Sleepiness Scale. Participants were 431 individuals working in medium-sized public service units. Sleepiness (Karolinska Sleepiness Scale, scale 1-9) was rated at six times a day for a working week and 2 days off (>90...
March 29, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28342886/using-genetic-data-to-improve-species-distribution-models
#12
Jérémy Bouyer, Renaud Lancelot
Tsetse flies (Diptera, Glossinidae) transmit human and animal trypanosomoses in Africa, respectively a neglected human disease (sleeping sickness) and the most important constraint to cattle production in infested countries (nagana). We recently developed a methodology to map landscape friction (i.e. resistance to movement) for tsetse in West Africa. The goal was to identify natural barriers to tsetse dispersal, and potentially isolated tsetse populations for targeting elimination programmes. Most species distribution models neglect landscape functional connectivity whereas environmental factors affecting suitability or abundance are not necessarily the same as those influencing gene flows...
March 23, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28340584/validation-of-the-german-version-of-two-scales-ris-rcs-hcp-for-measuring-regret-associated-with-providing-healthcare
#13
Silvia C Richner, Stéphane Cullati, Boris Cheval, Ralph E Schmidt, Pierre Chopard, Christoph A Meier, Delphine S Courvoisier
BACKGROUND: The regret intensity scale (RIS) and the regret coping scale for healthcare professionals (RCS-HCP) working in hospitals assess the experience of care-related regrets and how healthcare professional deal with these negative events. The aim of this study was to validate a German version of the RIS and the RCS-HCP. METHODS: The RIS and RCS-HCP in German were first translated into German (forward- and backward translations) and then pretested with 16 German-speaking healthcare professionals...
March 24, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28334017/genome-wide-rnai-selection-identifies-a-regulator-of-transmission-stage-enriched-gene-families-and-cell-type-differentiation-in-trypanosoma-brucei
#14
Eva Rico, Alasdair Ivens, Lucy Glover, David Horn, Keith R Matthews
Trypanosoma brucei, causing African sleeping-sickness, exploits quorum-sensing (QS) to generate the 'stumpy forms' necessary for the parasite's transmission to tsetse-flies. These quiescent cells are generated by differentiation in the bloodstream from proliferative slender forms. Using genome-wide RNAi selection we screened for repressors of transmission stage-enriched mRNAs in slender forms, using the stumpy-elevated ESAG9 transcript as a model. This identified REG9.1, whose RNAi-silencing alleviated ESAG9 repression in slender forms and tsetse-midgut procyclic forms...
March 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28329305/association-between-spousal-suicide-and-mental-physical-and-social-health-outcomes-a-longitudinal-and-nationwide-register-based-study
#15
Annette Erlangsen, Bo Runeson, James M Bolton, Holly C Wilcox, Julie L Forman, Jesper Krogh, M Katherine Shear, Merete Nordentoft, Yeates Conwell
Importance: Bereavement after spousal suicide has been linked to mental disorders; however, a comprehensive assessment of the effect of spousal suicide is needed. Objective: To determine whether bereavement after spousal suicide was linked to an excessive risk of mental, physical, and social health outcomes when compared with the general population and spouses bereaved by other manners. Design, Setting, and Participants: This nationwide, register-based cohort study conducted in Denmark of 6...
May 1, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28325373/host-parasite-relationships-and-life-histories-of-trypanosomes-in-australia
#16
C Cooper, P L Clode, C Peacock, R C A Thompson
Trypanosomes constitute a group of flagellate protozoan parasites responsible for a number of important, yet neglected, diseases in both humans and livestock. The most significantly studied include the causative agents of African sleeping sickness (Trypanosoma brucei) and Chagas disease (Trypanosoma cruzi) in humans. Much of our knowledge about trypanosome host-parasite relationships and life histories has come from these two human pathogens. Recent investigations into the diversity and life histories of wildlife trypanosomes in Australia highlight that there exists a great degree of biological and behavioural variation within and between trypanosomes...
2017: Advances in Parasitology
https://www.readbyqxmd.com/read/28321277/clinical-outcomes-among-febrile-children-aged-2-to-59-months-with-negative-malaria-rapid-diagnostic-test-results-in-mchinji-district-malawi
#17
Dyson Mwandama, Chawanangwa Mwale, Andrew Bauleni, Themba Phiri, Joseph Chisaka, Humphreys Nsona, Don P Mathanga
BACKGROUND: Malawi malaria treatment guidelines recommend a definitive diagnosis, using a malaria rapid diagnostic test (mRDT), for all patients with fever or history of fever. Improving the management and outcomes of febrile children with negative mRDT results should be a priority. METHODS: Through a prospective cohort study designed to investigate clinical outcomes of children treated at the community level, we followed, for 7 days, children aged 2 to 59 months, who had negative mRDT results and were treated with antipyretic medication...
December 2016: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/28321260/loop-mediated-isothermal-amplification-test-for-trypanosoma-gambiense-group-1-with-stem-primers-a-molecular-xenomonitoring-test-for-sleeping-sickness
#18
Zablon K Njiru, Cecilia K Mbae, Gitonga N Mburugu
The World Health Organization has targeted Human African Trypanosomiasis (HAT) for elimination by 2020 with zero incidence by 2030. To achieve and sustain this goal, accurate and easy-to-deploy diagnostic tests for Gambian trypanosomiasis which accounts for over 98% of reported cases will play a crucial role. Most needed will be tools for surveillance of pathogen in vectors (xenomonitoring) since population screening tests are readily available. The development of new tests is expensive and takes a long time while incremental improvement of existing technologies that have potential for xenomonitoring may offer a shorter pathway to tools for HAT surveillance...
2017: Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28288095/trypanosoma-brucei-metabolism-is-under-circadian-control
#19
Filipa Rijo-Ferreira, Daniel Pinto-Neves, Nuno L Barbosa-Morais, Joseph S Takahashi, Luisa M Figueiredo
The Earth's rotation forced life to evolve under cyclic day and night environmental changes. To anticipate such daily cycles, prokaryote and eukaryote free-living organisms evolved intrinsic clocks that regulate physiological and behavioural processes. Daily rhythms have been observed in organisms living within hosts, such as parasites. Whether parasites have intrinsic molecular clocks or whether they simply respond to host rhythmic physiological cues remains unknown. Here, we show that Trypanosoma brucei, the causative agent of human sleeping sickness, has an intrinsic circadian clock that regulates its metabolism in two different stages of the life cycle...
March 13, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28284860/synthesis-and-activity-of-nucleoside-based-antiprotozoan-compounds
#20
Huu-Anh Tran, Zhaoyan Zheng, Xianghui Wen, Srinivasan Manivannan, Arnaud Pastor, Marcel Kaiser, Reto Brun, Floyd F Snyder, Thomas G Back
Parasitic protozoa employ a salvage pathway to synthesize purines and generate essential active nucleotides, whereas mammals are capable of their de novo biosynthesis. This difference provides opportunity for the design of potential new antiprotozoan compounds. A series of 47 adenosine analogues was prepared with modifications at the 2-, 6- and 5'-positions, based on the hypothesis that such compounds would serve as substrates for protozoan nucleoside salvage enzymes, while remaining refractory in mammalian cells...
February 16, 2017: Bioorganic & Medicinal Chemistry
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