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https://www.readbyqxmd.com/read/28809638/-four-corner-arthrodesis-of-the-wrist-with-dorsal-circular-plate-a-retrospective-monocentric-study
#1
T Zatrapa, D Veigl, J Pech, I Landor, M Šimková
PURPOSE OF THE STUDY Our study aimed to evaluate a group of patients who in the period from 2005 to 2014 underwent a four-corner arthrodesis of the wrist in our department. We also wanted to verify the hypothesis as to whether the use of conventional dorsal plate without the application of bone grafts leads to comparable results as the use of dorsal locking plates and routine application of bone grafts. MATERIAL AND METHODS Throughout the years 2005 to 2014 the four-corner arthrodesis of the wrist was performed in our department in a total of 62 patients, in two cases bilaterally...
2017: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28807010/angiogenic-potency-evaluation-of-cell-therapy-candidates-by-a-novel-application-of-the-in-vitro-aortic-ring-assay
#2
Farwah Iqbal, Peter Szaraz, Matthew Librach, Andrée Gauthier-Fisher, Clifford L Librach
BACKGROUND: Due to limitations of current angiogenesis assays, we aimed to develop a novel application of the rat aortic ring assay to assess the angiogenic potential of mesenchymal stromal cells (MSCs). First-trimester human umbilical cord-derived perivascular cells (FTM HUCPVCs) have multipotent characteristics and previously demonstrated angiogenic potential. We compared the effect of this young source of MSCs and adult bone marrow stromal cells (BMSCs) on ex vivo aortic endothelial network formation...
August 14, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28797690/stem-cells-distribution-cellular-proliferation-and-migration-in-the-adult-austrolebias-charrua-brain
#3
Maximiliano Torres-Pérez, Juan Carlos Rosillo, Ines Berrosteguieta, Silvia Olivera-Bravo, Gabriela Casanova, José Manuel García-Verdugo, Anabel Sonia Fernández
Our previous studies demonstrated that Austrolebias charrua annual fish is an excellent model to study adult brain cell proliferation and neurogenesis due to the presence of active and fast neurogenesis in several regions during its short lifespan. Our main goal was to identify and localize the cells that compose the neurogenic areas throughout the Austrolebias brain. To do this, we used two thymidine halogenated analogs to detect cell proliferation at different survival times: 5-chloro-2́-deoxyuridine (CldU) at 1 day and 5-iodo-2́-deoxyuridine (IdU) at 30 days...
August 7, 2017: Brain Research
https://www.readbyqxmd.com/read/28777535/electrospun-nanofibers-new-concepts-materials-and-applications
#4
Jiajia Xue, Jingwei Xie, Wenying Liu, Younan Xia
Electrospinning is a simple and versatile technique that relies on the electrostatic repulsion between surface charges to continuously draw nanofibers from a viscoelastic fluid. It has been applied to successfully produce nanofibers, with diameters down to tens of nanometers, from a rich variety of materials, including polymers, ceramics, small molecules, and their combinations. In addition to solid nanofibers with a smooth surface, electrospinning has also been adapted to generate nanofibers with a number of secondary structures, including those characterized by a porous, hollow, or core-sheath structure...
August 4, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28759840/an-experimental-canine-patent-ductus-arteriosus-occlusion-device-based-on-shape-memory-polymer-foam-in-a-nitinol-cage
#5
Mark A Wierzbicki, Sarah B Raines, Sonya G Gordon, John C Criscione, Ashley B Saunders, Scott Birch, Bradley Due, Brandis Keller, Landon D Nash, Matthew W Miller, Duncan J Maitland
Patent ductus arteriosus (PDA) is a congenital cardiovascular defect in which a fetal connection between the aorta and pulmonary artery does not spontaneously close shortly after birth. If left uncorrected serious complications and even death can occur. Surgical ligation is the traditional treatment method; however, it is an invasive procedure, that motivates development of a minimally invasive option. Shape memory polymer (SMP) foams are unique materials that hold promise in the field of minimally invasive occlusion devices...
July 25, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28753616/regeneration-of-the-digestive-system-in-the-crinoid-himerometra-robustipinna-occurs-by-transdifferentiation-of-neurosecretory-like-cells
#6
Nadezhda V Kalacheva, Marina G Eliseikina, Lidia T Frolova, Igor Yu Dolmatov
The structure and regeneration of the digestive system in the crinoid Himerometra robustipinna (Carpenter, 1881) were studied. The gut comprises a spiral tube forming radial lateral processes, which gives it a five-lobed shape. The digestive tube consists of three segments: esophagus, intestine, and rectum. The epithelia of these segments have different cell compositions. Regeneration of the gut after autotomy of the visceral mass progresses very rapidly. Within 6 h after autotomy, an aggregation consisting of amoebocytes, coelomic epithelial cells and juxtaligamental cells (neurosecretory neurons) forms on the inner surface of the skeletal calyx...
2017: PloS One
https://www.readbyqxmd.com/read/28739273/analysis-of-packing-microstructure-and-wall-effects-in-a-narrow-bore-ultrahigh-pressure-liquid-chromatography-column-using-focused-ion-beam-scanning-electron-microscopy
#7
Arved E Reising, Sabine Schlabach, Vasili Baranau, Daniela Stoeckel, Ulrich Tallarek
Column wall effects are well recognized as major limiting factor in achieving high separation efficiency in HPLC. This is especially important for modern analytical columns packed with small particles, where wall effects dominate the band broadening. Detailed knowledge about the packing microstructure of packed analytical columns has so far not been acquired. Here, we present the first three-dimensional reconstruction protocol for these columns utilizing focused ion-beam scanning electron microscopy (FIB-SEM) on a commercial 2...
July 14, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28730857/controversies-in-complex-percutaneous-coronary-intervention-radial-versus-femoral
#8
Ian C Gilchrist, Stephen O Awuor, Rhian E Davies, Anene C Ukaigwe
Evolution in the technology used in the cardiac catheterization laboratory has permitted a migration from the femoral to radial artery access for many interventional procedures while concurrently improving outcomes. As a disruptive technology, transradial access has been associated with several controversies including a dichotomous relationship with femoral access. Areas covered: Several different patient subsets along with perceived technical challenges in interventional cardiology are reviewed with regard to the issue of access site...
July 21, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28720200/influence-of-erythrocyte-aggregation-on-radial-migration-of-platelet-sized-spherical-particles-in-shear-flow
#9
Cyrille Guilbert, Boris Chayer, Louise Allard, François T H Yu, Guy Cloutier
Blood platelets when activated are involved in the mechanisms of hemostasis and thrombosis, and their migration toward injured vascular endothelium necessitates interaction with red blood cells (RBCs). Rheology co-factors such as a high hematocrit and a high shear rate are known to promote platelet mass transport toward the vessel wall. Hemodynamic conditions promoting RBC aggregation may also favor platelet migration, particularly in the venous system at low shear rates. The aim of this study was to confirm experimentally the impact of RBC aggregation on platelet-sized micro particle migration in a Couette flow apparatus...
July 5, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28700939/neogenin-recruitment-of-the-wave-regulatory-complex-to-ependymal-and-radial-progenitor-adherens-junctions-prevents-hydrocephalus
#10
Conor J O'Leary, Cathrin C Nourse, Natalie K Lee, Amanda White, Michael Langford, Kai Sempert, Stacey J Cole, Helen M Cooper
Denudation of the ependyma due to loss of cell adhesion mediated by cadherin-based adherens junctions is a common feature of perinatal hydrocephalus. Junctional stability depends on the interaction between cadherins and the actin cytoskeleton. However, the molecular mechanism responsible for recruiting the actin nucleation machinery to the ependymal junction is unknown. Here, we reveal that loss of the netrin/RGM receptor, Neogenin, leads to severe hydrocephalus. We show that Neogenin plays a critical role in actin nucleation in the ependyma by anchoring the WAVE regulatory complex (WRC) and Arp2/3 to the cadherin complex...
July 11, 2017: Cell Reports
https://www.readbyqxmd.com/read/28694236/fibrin-functionalization-with-synthetic-adhesive-ligands-interacting-with-%C3%AE-6%C3%AE-1-integrin-receptor-enhance-neurite-outgrowth-of-embryonic-stem-cell-derived-neural-stem-progenitors
#11
Joana Silva, Ana R Bento, Daniela Barros, Tiago L Laundos, Susana R Sousa, Pedro Quelhas, Mónica M Sousa, Ana P Pêgo, Isabel F Amaral
To enhance fibrin hydrogel affinity towards pluripotent stem cell-derived neural stem/progenitor cells (NSPCs) and its capacity to support NSPC migration and neurite extension, we explored the tethering of synthetic peptides engaging integrin α6β1, a cell receptor enriched in NSPCs. Six α6β1 integrin ligands were tested for their ability to support integrin α6β1-mediated adhesion of embryonic stem cell-derived NSPCs (ES-NSPs) and sustain ES-NSPC viability, migration, and neuronal differentiation. Due to their better performance, peptides T1, HYD1, and A5G81 were immobilized into fibrin and functionalized gels characterized in terms of peptide binding efficiency, structure and viscoelastic properties...
September 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28688720/preparation-and-evaluation-of-mesoporous-silica-layers-on-radially-elongated-pillars
#12
Shunta Futagami, Takeshi Hara, Heidi Ottevaere, Gino V Baron, Gert Desmet, Wim De Malsche
The present paper describes the application of a sol-gel procedure on radially elongated pillars (REPs) using tetramethoxysilane and methyltrimethoxysilane. After octadecylsilylation, the quality of the porous layered REP (PLREP) columns was evaluated by in-situ determination of migration velocities and band broadening of coumarin dyes with fluorescence microscopy in reversed-phase liquid chromatography. Based on the increase in retention due to the sol-gel process, an increase in accessible specific surface by a factor of 112 was observed...
June 24, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28670268/serping1-c1-inhibitor-affects-cortical-development-in-a-cell-autonomous-and-non-cell-autonomous-manner
#13
Anna Gorelik, Tamar Sapir, Trent M Woodruff, Orly Reiner
Current knowledge regarding regulation of radial neuronal migration is mainly focused on intracellular molecules. Our unbiased screen aimed at identification of non-cell autonomous mechanisms involved in this process detected differential expression of Serping1 or C1 inhibitor, which is known to inhibit the initiation of the complement cascade. The complement cascade is composed of three pathways; the classical, lectin, and the alternative pathway; the first two are inhibited by C1 inhibitor, and all three converge at the level of C3...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28615204/human-cytomegalovirus-ie2-protein-disturbs-brain-development-by-dysregulating-neural-stem-cell-maintenance-and-the-polarization-of-migrating-neurons
#14
Dasol Han, Sung-Hyun Byun, Juwan Kim, Mookwang Kwon, Samuel J Pleasure, Jin-Hyun Ahn, Keejung Yoon
Despite the high incidence of severe defects in the central nervous system caused by human cytomegalovirus (HCMV) congenital infection, the mechanism of HCMV neuropathogenesis and the roles of individual viral genes have not yet been fully determined. In this study, we show that the immediate-early 2 (IE2) protein may play a key role in HCMV-caused neurodevelopmental disorders. IE2-transduced neural progenitor cells gave rise to neurospheres with a lower frequency and produced smaller neurospheres than control cells in vitro, indicating reduction of self-renewal and expansion of neural progenitors by IE2...
June 14, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28588454/reelin-signaling-inactivates-cofilin-to-stabilize-the-cytoskeleton-of-migrating-cortical-neurons
#15
REVIEW
Michael Frotscher, Shanting Zhao, Shaobo Wang, Xuejun Chai
Neurons are highly polarized cells. They give rise to several dendrites but only one axon. In addition, many neurons show a preferred orientation. For example, pyramidal neurons of the cerebral cortex extend their apical dendrites toward the cortical surface while their axons run in opposite direction toward the white matter. This characteristic orientation reflects the migratory trajectory of a pyramidal cell during cortical development: the leading process (the future apical dendrite) extends toward the marginal zone (MZ) and the trailing process (the future axon) toward the intermediate zone (IZ) while the cells migrate radially to reach their destination in the cortical plate (CP)...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28567152/a-complicated-course-of-a-coronal-shear-fracture-type-iv-of-the-distal-part-of-humerus-resulting-in-resurfacing-radiocapitellar-joint-replacement
#16
Ingo Schmidt
BACKGROUND: Coronal shear fracture type IV of the distal part of humerus is a very rare injury with articular complexity potentially leading to posttraumatic osteoarthritis. One option for surgical treatment of advanced unicompartmental radiocapitellar osteoarthritis is resurfacing radiocapitellar joint replacement. METHOD: A 62-year- old female sustained a coronal shear fracture type IV of the distal part of left humerus that was primarily treated with open reduction and internal fixation using headless compression screws...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28566327/the-influence-of-cement-thickness-on-stem-subsidence-and-cement-creep-in-a-collarless-polished-tapered-stem-when-are-thick-cement-mantles-detrimental
#17
E Takahashi, A Kaneuji, R Tsuda, Y Numata, T Ichiseki, K Fukui, N Kawahara
OBJECTIVES: Favourable results for collarless polished tapered stems have been reported, and cement creep due to taper slip may be a contributing factor. However, the ideal cement thickness around polished stems remains unknown. We investigated the influence of cement thickness on stem subsidence and cement creep. METHODS: We cemented six collarless polished tapered (CPT) stems (two stems each of small, medium and large sizes) into composite femurs that had been reamed with a large CPT rasp to achieve various thicknesses of the cement mantle...
May 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28562594/guided-self-organization-and-cortical-plate-formation-in-human-brain-organoids
#18
Madeline A Lancaster, Nina S Corsini, Simone Wolfinger, E Hilary Gustafson, Alex W Phillips, Thomas R Burkard, Tomoki Otani, Frederick J Livesey, Juergen A Knoblich
Three-dimensional cell culture models have either relied on the self-organizing properties of mammalian cells or used bioengineered constructs to arrange cells in an organ-like configuration. While self-organizing organoids excel at recapitulating early developmental events, bioengineered constructs reproducibly generate desired tissue architectures. Here, we combine these two approaches to reproducibly generate human forebrain tissue while maintaining its self-organizing capacity. We use poly(lactide-co-glycolide) copolymer (PLGA) fiber microfilaments as a floating scaffold to generate elongated embryoid bodies...
July 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28536274/mapping-22q11-2-gene-dosage-effects-on-brain-morphometry
#19
Amy Lin, Christopher R K Ching, Ariana Vajdi, Daqiang Sun, Rachel K Jonas, Maria Jalbrzikowski, Leila Kushan-Wells, Laura Pacheco Hansen, Emma Krikorian, Boris Gutman, Deepika Dokoru, Gerhard Helleman, Paul M Thompson, Carrie E Bearden
Reciprocal chromosomal rearrangements at the 22q11.2 locus are associated with elevated risk of neurodevelopmental disorders. The 22q11.2 deletion confers the highest known genetic risk for schizophrenia, but a duplication in the same region is strongly associated with autism and is less common in schizophrenia cases than in the general population. Here we conducted the first study of 22q11.2 gene dosage effects on brain structure in a sample of 143 human subjects: 66 with 22q11.2 deletions (22q-del; 32 males), 21 with 22q11...
May 23, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28523566/radial-glia-cells-control-angiogenesis-in-the-developing-cerebral-cortex-through-tgf-%C3%AE-1-signaling
#20
Michele Siqueira, Daniel Francis, Diego Gisbert, Flávia Carvalho Alcantara Gomes, Joice Stipursky
Neuroangiogenesis in the developing central nervous system is controlled by interactions between endothelial cells (ECs) and radial glia (RG) neural stem cells, although RG-derived molecules implicated in these events are not fully known. Here, we investigated the role of RG-secreted TGF-β1, in angiogenesis in the developing cerebral cortex. By isolation of murine microcapillary brain endothelial cells (MBECs), we demonstrate that conditioned medium from RG cultures (RG-CM) promoted MBEC migration and formation of vessel-like structures in vitro, in a TGF-β1-dependent manner...
May 18, 2017: Molecular Neurobiology
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