Gregor S Cremosnik, Yannick Mesrouze, Patrik Zueger, David Furkert, Frédéric Grandjean, Dayana Argoti, Fanny Mermet-Meillon, Matthias R Bauer, Scott Brittain, Phuong Rogemoser, Winnie Yang, Jerome Giovannoni, Lynn McGregor, Jenny Tang, Mark Knapp, Sandra Holzinger, Sylvia Buhr, Lionel Muller, Lukas Leder, Lili Xie, Cesar Fernandez, Cristina Nieto-Oberhuber, Patrick Chène, Giorgio G Galli, Fabian Sesterhenn
The ARID1A and ARID1B subunits are mutually exclusive components of the BAF variant of SWI/SNF chromatin remodeling complexes. Loss of function mutations in ARID1A are frequently observed in various cancers, resulting in a dependency on the paralog ARID1B for cancer cell proliferation. However, ARID1B has never been targeted directly, and the high degree of sequence similarity to ARID1A poses a challenge for the development of selective binders. In this study, we used mRNA display to identify peptidic ligands that bind with nanomolar affinities to ARID1B and showed high selectivity over ARID1A...
April 24, 2024: ACS Chemical Biology