Neda Vishlaghi, Lei Guo, Danielle Griswold-Wheeler, Yuxiao Sun, Cori Booker, Janna L Crossley, Alec C Bancroft, Conan Juan, Sneha Korlakunta, Sowmya Ramesh, Chase A Pagani, Lin Xu, Aaron W James, Robert J Tower, Michael Dellinger, Benjamin Levi
Heterotopic ossification (HO) is a challenging condition that occurs after musculoskeletal injury and is characterized by the formation of bone in non-skeletal tissues. While the effect of HO on blood vessels is well established, little is known about its impact on lymphatic vessels. Here, we use a mouse model of traumatic HO to investigate the relationship between HO and lymphatic vessels. We show that injury triggers lymphangiogenesis at the injury site, which is associated with elevated vascular endothelial growth factor C (VEGF-C) levels...
April 3, 2024: Cell Reports