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https://www.readbyqxmd.com/read/27911356/importance-rat-liver-morphology-and-vasculature-in-surgical-research
#1
Katarína Vdoviaková, Katarína Vdoviaková, Eva Petrovová, Lenka Krešáková, Marcela Maloveská, Jana Teleky, Janka Jenčová, Jozef Živčák, Andrej Jenča
BACKGROUND The laboratory rat is one of the most popular experimental models for the experimental surgery of the liver. The objective of this study was to investigate the morphometric parameters, physiological data, differences in configuration of liver lobes, biliary system, and vasculature (arteries, veins, and lymphatic vessels) of the liver in laboratory rats. In addition, this study supports the anatomic literature and identified similarities and differences with human and other mammals. MATERIAL AND METHODS Forty laboratory rats were dissected to prepare corrosion casts of vascular system specimens (n=20), determine the lymph vessels and lymph nodes (n=10), and for macroscopic anatomical dissection (n=10) of the rat liver...
December 2, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27909960/effects-of-melatonin-aluminum-oxide-and-polymethylsiloxane-complex-on-the-expression-of-lyve-1-in-the-liver-of-mice-with-obesity-and-type-2-diabetes-mellitus
#2
S V Michurina, I Yu Ishchenko, S A Arkhipov, V V Klimontov, L N Rachkovskaya, V I Konenkov, E L Zavyalov
The effects of melatonin, aluminum oxide, and polymethylsiloxane complex on the expression of LYVE-1 (lymphatic vessel endothelial hyaluronan receptor) in the liver were studied in db/db mice with experimental obesity and type 2 diabetes mellitus. The complex or placebo was administered daily by gavage from week 8 to week 16 of life. The animals receiving the complex exhibited enhanced, in comparison with the placebo group, immunohistochemical LYVE-1+ staining of endothelial cells in sinusoids. Enhanced expression of LYVE-1 was associated with less pronounced dilatation of interlobular arteries, veins, and lymphatic vessels...
December 1, 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27899779/-two-resected-cases-with-superficial-basaloid-squamous-carcinoma-of-the-esophagus
#3
Mamiko Takii, Masashi Takemura, Nobuaki Kaibe, Tsutomu Ohshima, Syojirou Kikuchi, Mitsuru Sasako
We report 2 resected cases of superficial type basaloid squamous cell carcinoma of the esophagus. Case 1 is a 67-year-old man who underwent endoscopic submucosalresection for superficialel evated type esophagealcancer of the middle thoracic esophagus. Because the pathological diagnosis of the resected specimen was basaloid squamous cell carcinoma invading to the submucosal layer with lymphatic vessel invasion, esophagectomy was indicated. The resected specimens showed no tumor in the esophagus. However, metastasis was diagnosed in the dissected mediastinall ymph nodes...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27899284/defective-lymphatic-valve-development-and-chylothorax-in-mice-with-a-lymphatic-specific-deletion-of-connexin43
#4
Stephanie J Munger, Michael J Davis, Alexander M Simon
Lymphatic valves (LVs) are cusped luminal structures that permit the movement of lymph in only one direction and are therefore critical for proper lymphatic vessel function. Congenital valve aplasia or agenesis can, in some cases, be a direct cause of lymphatic disease. Knowledge about the molecular mechanisms operating during the development and maintenance of LVs may thus aid in the establishment of novel therapeutic approaches to treat lymphatic disorders. In this study, we examined the role of Connexin43 (Cx43), a gap junction protein expressed in lymphatic endothelial cells (LECs), during valve development...
November 26, 2016: Developmental Biology
https://www.readbyqxmd.com/read/27895822/linagliptin-alleviates-fatty-liver-disease-in-diabetic-db-db-mice
#5
Svetlana V Michurina, Irina Ju Ishenko, Vadim V Klimontov, Sergey A Archipov, Natalia E Myakina, Marina A Cherepanova, Eugenii L Zavjalov, Galina V Koncevaya, Vladimir I Konenkov
AIM: To study the effects of linagliptin on the structural signs of non-alcoholic fatty liver disease (NAFLD) in db/db mice. METHODS: Male diabetic db/db mice (BKS.Cg-Dock7(m+)/(+)Lepr(db)/J) aged 10 wk received the dipeptidyl peptidase 4 (DPP4) inhibitor linagliptin (10 mg/kg) or saline as a placebo once per day by gavage for 8 wk. Intact db/db mice served as controls. Structural changes in the liver were analyzed from light and electron microscopic images of sections from intact, placebo-treated and linagliptin-treated animals...
November 15, 2016: World Journal of Diabetes
https://www.readbyqxmd.com/read/27889769/immunohistochemical-heterogeneity-of-the-endothelium-of-blood-and-lymphatic-vessels-in-the-developing-human-liver-and-in-adulthood
#6
Ivan Nikolić, Vera Todorović, Aleksandar Petrović, Vladimir Petrović, Marko Jović, Jelena Vladičić, Nela Puškaš
The endothelium of liver sinusoids in relation to the endothelium of other blood vessels has specific antigen expression similar to the endothelium of lymphatic vessels. Bearing in mind that there is no consensus as to the period or intensity of the expression of certain antigens in the endothelium of blood and lymphatic vessels in the liver, the aim of our study was to immunohistochemically investigate the dynamic patterns of the expression of CD31, CD34, D2-40, and LYVE-1 antigens during liver development and in adulthood on paraffin tissue sections of human livers of 4 embryos, 38 fetuses, 6 neonates, and 6 adults...
November 26, 2016: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/27888192/atypical-chemokine-receptor-ackr2-controls-branching-morphogenesis-in-the-developing-mammary-gland
#7
Gillian J Wilson, Kay D Hewit, Kenneth J Pallas, Claire J Cairney, Kit M Lee, Christopher A Hansell, Torsten Stein, Gerard J Graham
Macrophages are important regulators of branching morphogenesis during development, and postnatally in the mammary gland. Regulation of macrophage dynamics during these processes can therefore have a profound impact on development. We demonstrate here that the developing mammary gland expresses high levels of inflammatory CC-chemokines which are essential in vivo regulators of macrophage migration. We further demonstrate that the atypical chemokine receptor ACKR2, which scavenges inflammatory CC-chemokines, is differentially expressed during mammary gland development...
November 25, 2016: Development
https://www.readbyqxmd.com/read/27886553/mechanical-stress-regulates-transport-in-a-compliant-3d-model-of-the-blood-brain-barrier
#8
Paul P Partyka, George A Godsey, John R Galie, Mary C Kosciuk, Nimish K Acharya, Robert G Nagele, Peter A Galie
Transport of fluid and solutes is tightly controlled within the brain, where vasculature exhibits a blood-brain barrier and there is no organized lymphatic network facilitating waste transport from the interstitial space. Here, using a compliant, three-dimensional co-culture model of the blood-brain barrier, we show that mechanical stimuli exerted by blood flow mediate both the permeability of the endothelial barrier and waste transport along the basement membrane. Application of both shear stress and cyclic strain facilitates tight junction formation in the endothelial monolayer, with and without the presence of astrocyte endfeet in the surrounding matrix...
November 17, 2016: Biomaterials
https://www.readbyqxmd.com/read/27881983/high-endothelial-venules-and-lymphatic-vessels-in-tertiary-lymphoid-organs-characteristics-functions-and-regulation
#9
REVIEW
Nancy H Ruddle
High endothelial venules (HEVs) and lymphatic vessels (LVs) are essential for the function of the immune system, by providing communication between the body and lymph nodes (LNs), specialized sites of antigen presentation and recognition. HEVs bring in naïve and central memory cells and LVs transport antigen, antigen-presenting cells, and lymphocytes in and out of LNs. Tertiary lymphoid organs (TLOs) are accumulations of lymphoid and stromal cells that arise and organize at ectopic sites in response to chronic inflammation in autoimmunity, microbial infection, graft rejection, and cancer...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27880905/semaphorin-3g-provides-a-repulsive-guidance-cue-to-lymphatic-endothelial-cells-via-neuropilin-2-plexind1
#10
Xinyi Liu, Akiyoshi Uemura, Yoko Fukushima, Yutaka Yoshida, Masanori Hirashima
The vertebrate circulatory system is composed of closely related blood and lymphatic vessels. It has been shown that lymphatic vascular patterning is regulated by blood vessels during development, but its molecular mechanisms have not been fully elucidated. Here, we show that the artery-derived ligand semaphorin 3G (Sema3G) and the endothelial cell receptor PlexinD1 play a role in lymphatic vascular patterning. In mouse embryonic back skin, genetic inactivation of Sema3G or PlexinD1 results in abnormal artery-lymph alignment and reduced lymphatic vascular branching...
November 22, 2016: Cell Reports
https://www.readbyqxmd.com/read/27880904/lyve1-marks-the-divergence-of-yolk-sac-definitive-hemogenic-endothelium-from-the-primitive-erythroid-lineage
#11
Lydia K Lee, Yasamine Ghorbanian, Wenyuan Wang, Yanling Wang, Yeon Joo Kim, Irving L Weissman, Matthew A Inlay, Hanna K A Mikkola
The contribution of the different waves and sites of developmental hematopoiesis to fetal and adult blood production remains unclear. Here, we identify lymphatic vessel endothelial hyaluronan receptor-1 (LYVE1) as a marker of yolk sac (YS) endothelium and definitive hematopoietic stem and progenitor cells (HSPCs). Endothelium in mid-gestation YS and vitelline vessels, but not the dorsal aorta and placenta, were labeled by Lyve1-Cre. Most YS HSPCs and erythro-myeloid progenitors were Lyve1-Cre lineage traced, but primitive erythroid cells were not, suggesting that they represent distinct lineages...
November 22, 2016: Cell Reports
https://www.readbyqxmd.com/read/27879093/prognostic-value-of-the-area-and-density-of-lymphatic-vessels-in-cutaneous-squamous-cell-carcinoma
#12
Jorien Tannette Krediet, Jean Kanitakis, Adrienne Bob, Julia Schmitter, Annelot Carine Krediet, Joachim Röwert, Eggert Stockfleth, Clemens Painsi, Rainer Hügel, Dorothea Terhorst, Bernhard Lange-Asschenfeldt
BACKGROUND AND OBJECTIVES: Cutaneous squamous cell carcinoma (SCC) is known for its capacity to metastasize via lymphatic vessels. In recent studies, the level of lymphangiogenesis has been reported as a potential prognostic factor for several skin tumors. The aim of this study was to quantify lymphangiogenesis in SCC using either computer-assisted image analysis or the Chalkley count technique. Vascular parameters were evaluated and compared with respect to their predictive power for tumor metastasis...
November 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27877228/lymphangiogenesis-in-classical-hodgkin-lymphoma-preliminary-study-with-clinicopathological-correlations
#13
Daniel Benharroch, Isebrand Prinsloo, Jacob Gopas, Irena Lazarev
A role for lymphangiogenesis in metastatic breast and prostate cancers has been suggested recently. The relevance of lymphangiogenesis in cancer as a rule, and more specifically in classical Hodgkin lymphoma, is poorly understood in comparison with that of angiogenesis. In a preliminary (pilot) study we have investigated the role of lymphatic vessels growth in 19 cases of classical Hodgkin lymphoma stained with the D2-40 (podoplanin) antibody. In each case, three lymphatic vessels hot spots were scrutinized twice...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27876236/immunohistochemical-comparative-analysis-of-lymphatic-vessel-density-and-vegf-c-expression-in-squamous-cell-carcinomas-of-the-tongue-between-young-and-old-patients
#14
Jamile Marinho Bezerra de Oliveira Moura, Adriana Costa de Souza Martins Câmara, Cassiano Francisco Weege Nonaka, Leão Pereira Pinto, Lélia Batista de Souza
BACKGROUND: Squamous cell carcinoma (SCC) of the oral cavity is a malignant epithelial tumor that most commonly involves the tongue, and mainly affects men between the fifth and seventh decades of life. This study compared the lymphatic vessel density and VEGF-C expression in SCCs of the tongue between young and old patients. METHODS: Thirty-four SCCs of the tongue, 17 diagnosed in young patients (≤40y) and 17 diagnosed in old patients (>50y), were evaluated by immunohistochemistry...
November 2, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/27875806/mast-cells-and-histamine-are-triggering-the-nf-%C3%AE%C2%BAb-mediated-reactions-of-adult-and-aged-perilymphatic-mesenteric-tissues-to-acute-inflammation
#15
Irina Tsoy Nizamutdinova, Giuseppina F Dusio, Olga Yu Gasheva, Hunter Skoog, Richard Tobin, Chander Peddaboina, Cynthia J Meininger, David C Zawieja, M Karen Newell-Rogers, Anatoliy A Gashev
This study aimed to establish mechanistic links between the aging-associated changes in the functional status of mast cells and the altered responses of mesenteric tissue and mesenteric lymphatic vessels (MLVs) to acute inflammation. We used an in vivo model of acute peritoneal inflammation induced by lipopolysaccharide treatment of adult (9-month) and aged (24-month) F-344 rats. We analyzed contractility of isolated MLVs, mast cell activation, activation of nuclear factor-κB (NF-κB) without and with stabilization of mast cells by cromolyn or blockade of all types of histamine receptors and production of 27 major pro-inflammatory cytokines in adult and aged perilymphatic mesenteric tissues and blood...
November 21, 2016: Aging
https://www.readbyqxmd.com/read/27867844/surgical-approaches-for-varicocele-in-pediatric-patient
#16
Alejandra Parrilli, Agnese Roberti, Maria Escolino, Ciro Esposito
BACKGROUND: Varicocele represents one of the most common surgically correctible urologic anomalies in adolescent males. The best procedure for the treatment of adolescent varicocele has not been established, but with recent advances in minimal access surgery, there have been many reports praising the safety and efficacy of laparoscopy and retroperitoneoscopy for the surgical correction of varicocele in adolescent. The aim of this review is to compare the results of Palomo's technique, with retroperitoneoscopic and transperitoneoscopic approaches in adolescent, analyzing recurrence, testicular growth and complications...
October 2016: Translational pediatrics
https://www.readbyqxmd.com/read/27862361/primary-effusion-lymphoma-involving-cerebrospinal-fluid-deep-cervical-lymph-nodes-and-adenoids-report-of-a-case-supporting-the-lymphatic-connection-between-brain-and-lymph-nodes
#17
Carlos Santonja, Camino Medina-Puente, Cristina Serrano Del Castillo, Alfonso Cabello Úbeda, Socorro María Rodríguez-Pinilla
We describe an unusual presentation of primary effusion lymphoma in CSF of a 45-year-old HIV-positive man, with no evidence of involvement of pleural, peritoneal or pericardial cavities. Cytologic examination and flow cytometric analysis suggested the diagnosis, eventually made in an excised deep cervical lymph node, in which the neoplastic cells involved selectively the sinuses. This case represents the fifth reported example of CSF involvement by this type of lymphoma, and supports the alleged connection between CSF and cervical lymph nodes via lymphatic vessels...
November 10, 2016: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/27862152/cutaneous-polyarteritis-nodosa-localized-to-a-region-of-lymphedema-secondary-to-streptococcus-viridans-cellulitis-and-multiple-surgeries
#18
Andrew Matsumoto, Rami N Al-Rohil, Marina Bravin, Lori Anderson, Danielle Wroblewski, J Andrew Carlson
Cutaneous polyarteritis nodosa (CPAN) is a chronic, indolent, single organ arteritis that generally presents with lower extremity nodules and/or livedo racemosa, accompanied by malaise and arthralgias. CPAN is often triggered by infection, commonly Group A streptococcal species, and is considered an autoimmune reaction. Scarring from surgery and obliterative lymphangiitis from bacterial cellulitis are causes of lymphedema. Lymphedematous skin is predisposed to autoimmune disorders. Herein we report a 53yo woman who developed CPAN restricted to a localized area of the right upper arm-shoulder that had undergone multiple surgeries, complicated by episodes of Streptococcus viridans cellulitis...
November 10, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27859616/immunohistochemical-expression-of-podoplanin-d2-40-lymphangiogenesis-and-neoangiogenesis-in-tooth-germ-ameloblastomas-and-ameloblastic-carcinomas
#19
Celeste Sánchez-Romero, Ronell Bologna-Molina, Adalberto Mosqueda-Taylor, Oslei Paes de Almeida
BACKGROUND: Ameloblastoma is a benign but locally aggressive odontogenic tumor, while ameloblastic carcinoma is its malignant counterpart. Angiogenesis and lymphangiogenesis in malignancies have been correlated with higher aggressiveness and poor prognosis, as well as greater expression of podoplanin by tumoral cells. METHODS: Immunohistochemical expression of podoplanin, CD34, and CD105 (endoglin) was evaluated in 53 ameloblastomas and three ameloblastic carcinomas; additionally, immunohistochemistry for podoplanin was also performed in 10 tooth germs...
November 10, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27858364/the-rip1tag2-transgenic-mouse-model
#20
Ruben Bill, Gerhard Christofori
The Rip1Tag2 transgenic mouse model of β-cell carcinogenesis has been instrumental in studying various aspects of tumor angiogenesis and in investigating the response to anti-angiogenic therapeutics. Thereby, the in-depth assessment of blood and lymphatic vessel phenotypes and functionality represents key experimental analyses. In this chapter, we describe basic protocols to assess tumor blood vessel morphology (pericyte coverage), functionality (perfusion, leakiness, and hypoxia), lymphatic tumor coverage, and tumor cell proliferation and apoptosis based on immunofluorescence microscopy analysis...
2016: Methods in Molecular Biology
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