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lymphatic vessels

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https://www.readbyqxmd.com/read/28323646/endothelial-cells-and-lymphatics-at-the-interface-between-the-immune-and-central-nervous-systems-implications-for-multiple-sclerosis
#1
Céline Meyer, Guillaume Martin-Blondel, Roland S Liblau
PURPOSE OF REVIEW: The central nervous system (CNS) has a unique relationship with the immune system. This review highlights the distinct roles of lymphatic vessels and endothelial cells in the interface between CNS and immune cells and invites to revisit the concept of CNS immune privilege. RECENT FINDINGS: T cells can follow several routes to penetrate the CNS parenchyma but may also benefit, together with antigen-loaded presenting cells, from the newly described lymphatic network to exit the CNS...
March 18, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28323569/isolated-human-lymphatic-vessels-and-lymphatic-endothelial-cells
#2
Stanley G Rockson
No abstract text is available yet for this article.
March 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28318074/perforating-and-deep-lymphatic-vessels-in-the-knee-region-an-anatomical-study-and-clinical-implications
#3
Wei-Ren Pan, Fan-Qiang Zeng, De-Guang Wang, Zhi-Qiang Qiu
BACKGROUND: To determine the relationship between the perforating and deep lymphatic vessels in the knee region for clinical implications. METHODS: Four lower limbs from two unembalmed human cadavers were used. Under a surgical microscope, 6% hydrogen peroxide was employed to detect lymph vessels accompanying the small saphenous vein, anterior tibial, posterior tibial and fibular blood vessels all commencing from distal ends of specimens. Each lymphatic vessel was inserted by a 30-gauge needle and injected with a barium sulphate mixture...
March 20, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28315338/lymphatic-and-vascular-markers-in-an-optic-nerve-crush-model-in-rat
#4
A Trost, D Bruckner, A Kaser-Eichberger, K Motloch, B Bogner, C Runge, C Strohmaier, S Couillard-Despres, H A Reitsamer, F Schroedl
Only few tissues lack lymphatic supply, such as the CNS or the inner eye. However, if the scleral border is compromised due to trauma or tumor, lymphatics are detected in the eye. Since the situation in the optic nerve (ON), part of the CNS, is not clear, the aim of this study is to screen for the presence of lymphatic markers in the healthy and lesioned ON. Brown Norway rats received an unilateral optic nerve crush (ONC) with defined force, leaving the dura intact. Lesioned ONs and unlesioned contralateral controls were analyzed 7 days (n = 5) and 14 days (n = 5) after ONC, with the following markers: PDGFRb (pericyte), Iba1 (microglia), CD68 (macrophages), RECA (endothelial cell), GFAP (astrocyte) as well as LYVE-1 and podoplanin (PDPN; lymphatic markers)...
March 14, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28303284/-generalized-circumscribed-scleroderma-with-blisters
#5
G Wagner, V Meyer, M M Sachse
The patient suffered from a 20-year course of generalized circumscribed scleroderma and presented with blisters in circumscribed areas of the affected skin. The development of subepidermal blisters has been described in all clinical forms of circumscribed scleroderma. Aetiology and pathogenesis of blister formation have not yet been clarified. An obstruction of the lymphatic vessels due to the present sclerosis is favoured. Treatment of bullous circumscribed scleroderma is considered to be difficult. Oral steroids, methotrexate, hydroxychloroquine and PUVA methods have been used with varying success...
March 16, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28301852/high-fat-diet-in-the-absence-of-obesity-does-not-aggravate-surgically-induced-lymphoedema-in-mice
#6
Epameinondas Gousopoulos, Sinem Karaman, Steven T Proulx, Kristin Leu, Dorina Buschle, Michael Detmar
BACKGROUND: Lymphoedema represents the cardinal manifestation of lymphatic dysfunction and is associated with expansion of the adipose tissue in the affected limb. In mice, high-fat diet (HFD)-induced obesity was associated with impaired collecting lymphatic vessel function, and adiposity aggravated surgery-induced lymphoedema in a mouse model. The aim of the current study was to investigate whether adiposity is necessary to impair lymphatic function or whether increased lipid exposure alone might be sufficient in a surgical lymphoedema model...
March 17, 2017: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/28298335/hyperglycemia-and-hyperinsulinemia-induced-insulin-resistance-causes-alterations-in-cellular-bioenergetics-and-activation-of-inflammatory-signaling-in-lymphatic-muscle
#7
Yang Lee, James D Fluckey, Sanjukta Chakraborty, Mariappan Muthuchamy
Insulin resistance is a well-known risk factor for obesity, metabolic syndrome (MetSyn) and associated cardiovascular diseases, but its mechanisms are undefined in the lymphatics. Mesenteric lymphatic vessels from MetSyn or LPS-injected rats exhibited impaired intrinsic contractile activity and associated inflammatory changes. Hence, we hypothesized that insulin resistance in lymphatic muscle cells (LMCs) affects cell bioenergetics and signaling pathways that consequently alter contractility. LMCs were treated with different concentrations of insulin or glucose or both at various time points to determine insulin resistance...
March 15, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28297758/-role-of-master-transcriptional-factor-prox-1-in-lymphatic-endothelial-differentiation-of-kaposiform-hemangioendothelioma
#8
Z Y Ke, S J Yang
Objective: To analyze the clinical and pathological features of Kaposiform hemangioendothelioma (KHE), and to investigate the role of master transcriptional factor Prox-1 in the regulation of lymphatic differentiation. Methods: Nine cases of KHE (during the period from October 2009 to June 2016) were collected with clinical and pathological data. H&E stained section review and immunohistochemietry using the Dako EnVision method were performed. Results: There were 6 female and 3 male patients with age ranging from 2 months to 8 years (median 3 years and 4 months)...
March 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28297141/immunohistochemical-staining-of-pediatric-solitary-angiokeratomas
#9
Brea Prindaville, Hillary Lawrence, Vivekanand Singh, Amy J Nopper, Kimberly A Horii
The precise etiology and subtype of vessels constituting angiokeratomas is poorly understood. We sought to characterize the vessels by studying prospero-related homeobox gene-1 and D2-40 expression in 22 pediatric solitary angiokeratomas. Routine histologic examination demonstrated a mix of lymph-containing vessels and erythrocyte-filled small vessels. Our results suggest that angiokeratomas may in part be comprised of vessels with lymphatic differentiation.
March 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28288772/first-report-of-vascular-invasion-of-demodex-mites-with-thrombi-and-dissemination-to-visceral-lymph-nodes-in-a-dog
#10
Moges Woldemeskel, Ian Hawkins
An adult-onset generalized canine demodecosis is a life threatening form of demodecosis often seen in immunocompromised dogs. A generalized, adult-onset canine demodecosis with an unusual vascular invasion, thrombi and dissemination to peripheral, and visceral lymph nodes was diagnosed in an adult, female, American Bulldog of unknown age. Organized thrombi with intralesional mites were observed in multiple lymphatic vessels and in a section of blood vessel. Vascular invasion of mites with dissemination of mites into visceral lymph nodes, is an unusual findings not previously recorded in canine generalized demodecosis...
March 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28287740/mediating-passive-tumor-accumulation-through-particle-size-tumor-type-and-location
#11
Jillian L Perry, Kevin G Reuter, J Christopher Luft, Chad V Pecot, William C Zamboni, Joseph M DeSimone
As the enhanced permeation and retention (EPR) effect continues to be a controversial topic in nanomedicine, we sought to examine EPR as a function of nanoparticle size, tumor model and tumor location, while also evaluating tumors for EPR mediating factors such as microvessel density, vascular permeability, lymphatics, stromal content, and tumor associated immune cells. Tumor accumulation was evaluated for 55x60 nm, 80x180 nm, and 80x320 nm PRINT particles, in four subcutaneous flank tumor models (SKOV3 human ovarian, 344SQ murine non-small cell lung, A549 human non-small cell lung, and A431 human epidermoid cancer)...
March 13, 2017: Nano Letters
https://www.readbyqxmd.com/read/28287513/an-ex-vivo-method-for-time-lapse-imaging-of-cultured-rat-mesenteric-microvascular-networks
#12
Mohammad S Azimi, Jessica M Motherwell, Walter L Murfee
Angiogenesis, defined as the growth of new blood vessels from pre-existing vessels, involves endothelial cells, pericytes, smooth muscle cells, immune cells, and the coordination with lymphatic vessels and nerves. The multi-cell, multi-system interactions necessitate the investigation of angiogenesis in a physiologically relevant environment. Thus, while the use of in vitro cell-culture models have provided mechanistic insights, a common critique is that they do not recapitulate the complexity associated with a microvascular network...
February 9, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28287124/endogenous-tnf%C3%AE-orchestrates-the-trafficking-of-neutrophils-into-and-within-lymphatic-vessels-during-acute-inflammation
#13
Samantha Arokiasamy, Christian Zakian, Jessica Dilliway, Wen Wang, Sussan Nourshargh, Mathieu-Benoit Voisin
Neutrophils are recognised to play a pivotal role at the interface between innate and acquired immunities following their recruitment to inflamed tissues and lymphoid organs. While neutrophil trafficking through blood vessels has been extensively studied, the molecular mechanisms regulating their migration into the lymphatic system are still poorly understood. Here, we have analysed neutrophil-lymphatic vessel interactions in real time and in vivo using intravital confocal microscopy applied to inflamed cremaster muscles...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28277905/spontaneous-and-evoked-contractility-of-human-intestinal-lymphatic-vessels
#14
Niklas Telinius, Jens Majgaard, Sheyanth Mohanakumar, Einar Pahle, Jørn Nielsen, Vibeke Hjortdal, Christian Aalkjær, Donna Briggs Boedtkjer
BACKGROUND: Mesenteric lymphatic vessels (MLVs) from various animal species have been intensively studied. We aimed to establish the viability and basic contractile characteristics of human MLVs maintained in vitro and to determine the reactivity of MLVs with norepinephrine (NE) and substance P (SP) and to compare with the thoracic duct (TD). METHODS AND RESULTS: Isolated human lymphatic vessels were mounted on a wire myograph under isometric conditions and tension was recorded...
March 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28272715/could-mri-visualize-the-invisible-an-italian-single-center-study-comparing-magnetic-resonance-lymphography-mrl-super-microsurgery-and-histology-in-the-identification-of-lymphatic-vessels
#15
P Gennaro, A Borghini, G Chisci, F G Mazzei, E Weber, E Tedone Clemente, S Guerrini, F Gentili, G Gabriele, C Ungari, M A Mazzei
OBJECTIVE: Aim of this study is to evaluate the possibility of limb magnetic resonance lymphography (MRL) to differentiate lymphatic vessels from pathological veins, collect a specimen of the identified lymphatic vessel during operations of super microsurgical lymphatic-venular anastomosis (s-LVA) and perform immunohistochemical stainings to confirm the nature of the collected vessels. PATIENTS AND METHODS: Twenty patients presenting lymphedema were enrolled in this study...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28272235/unusual-cause-of-55-years-of-rectal-bleeding-hemolymphangioma-a-case-report
#16
Sagar Pandey, Miao Fan, Junfeng Zhu, Xiaofang Lu, Dandan Chang, Xiuhong Li
RATIONALE: Hemolymphangioma is a rare developmental error of combined blood and lymphatic vasculature. To the best of our knowledge, there is only one case of rectal hemolymphangioma reported in Pubmed. Our case probably is the first reported rectal hemolymphangioma with computed tomography (CT) evaluation. PATIENT CONCERNS AND DIAGNOSIS: A 57-year-old male was presented to our hospital with 55 years of long history of episodic rectal bleeding. Past medical history showed numerous hospital visits for similar illness...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28261938/mast-cell-disorders-in-ehlers-danlos-syndrome
#17
REVIEW
Suranjith L Seneviratne, Anne Maitland, Lawrence Afrin
Well known for their role in allergic disorders, mast cells (MCs) play a key role in homeostatic mechanisms and surveillance, recognizing and responding to different pathogens, and tissue injury, with an array of chemical mediators. After being recruited to connective tissues, resident MCs progenitors undergo further differentiation, under the influence of signals from surrounding microenvironment. It is the differential tissue homing and local maturation factors which result in a diverse population of resident MC phenotypes...
March 6, 2017: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://www.readbyqxmd.com/read/28259358/prognostic-significance-of-lymphatic-vascular-and-perineural-invasion-for-bladder-cancer-patients-treated-by-radical-cystectomy
#18
Prasuna Muppa, Sounak Gupta, Igor Frank, Stephen A Boorjian, R Jeffrey Karnes, R Houston Thompson, Prabin Thapa, Robert F Tarrell, Loren P Herrera Hernandez, Rafael E Jimenez, John C Cheville
In radical cystectomy specimens with bladder cancer, lymphatic and vascular invasion are often reported as 'angiolymphatic' or 'lymphovascular' invasion, terms that combine the findings of tumour within simple endothelial-lined lymphatic spaces and tumour within muscle-lined blood vessels. It is unclear if these patterns of invasion have different prognostic significance. In addition, there are conflicting data regarding the significance of lymphatic, vascular and perineural invasion in patients with bladder cancer...
March 1, 2017: Pathology
https://www.readbyqxmd.com/read/28254103/is-there-volume-transmission-along-extracellular-fluid-pathways-corresponding-to-the-acupuncture-meridians
#19
Weibo Zhang, Ze Wang, Shuyong Jia, Yuying Tian, Guangjun Wang, Hongyan Li, Kjell Fuxe
Volume transmission is a new major communication signaling via extracellular fluid (interstitial fluid) pathways. It was proposed by the current authors that such pathways can explain the meridian phenomena and acupuncture effects. To investigate whether meridian-like structures exist in fish body and operate via volume transmission in extracellular fluid pathways, we injected alcian blue (AB) under anesthesia into Gephyrocharax melanocheir, which has a translucent body. The migration of AB could be seen directly and was recorded by a digital camera...
January 2017: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/28253401/netrin-4-mediates-corneal-hemangiogenesis-but-not-lymphangiogenesis-in-the-mouse-model-of-suture-induced-neovascularization
#20
Anna-Karina B Maier, Sabrina Klein, Norbert Kociok, Aline I Riechardt, Enken Gundlach, Nadine Reichhart, Olaf Strauß, Antonia M Joussen
Purpose: Netrin-4, a secreted protein, is found in the basement membrane of blood vessels and acts as a key regulator of angiogenesis. Here we investigated the role of Netrin-4 in the mouse-model of suture-induced corneal hem- and lymphangiogenesis. Methods: Corneal hem- and lymphangiogenesis were induced in Netrin-4-deficient (Ntn4-/-) and wild-type (WT) mice by placing three 11-0 nylon sutures intrastromally. Fourteen days after suturing, the vascularized area was analyzed via corneal flat mount immunohistochemistry...
March 1, 2017: Investigative Ophthalmology & Visual Science
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