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https://www.readbyqxmd.com/read/29280039/left-ventricular-outflow-tract-arrhythmias-with-divergent-qrs-morphology-mapping-of-different-exits-and-ablation-strategy
#1
Christopher Reithmann, Michael Fiek
BACKGROUND: Ventricular arrhythmias (VAs) from the left ventricular outflow tract (LVOT) can have multiple exits exhibiting divergent ECG features. METHODS: In a series of 131 patients with VAs with LVOT origin, 10 patients presented with divergent QRS morphologies. Multisite endo- and epicardial mapping of different exit sites was performed. RESULTS: The earliest ventricular activity of 23 LVOT VAs in 10 patients was detected in the endocardium of the LV in 7 patients, the aortic sinuses of Valsalva (SoV) in 3 patients, the distal coronary sinus in 6 patients, the anterior interventricular vein in 3 patients, and the posterior right ventricular outflow tract (RVOT) in 4 patients...
December 27, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29276910/-a-rare-case-of-metastatic-tumor-of-heart-from-bludder-cancer
#2
A P Koval, G A Kukharchik, K V Dikarev, S R Minkin, L A Sorokin
The article presents a case report of metastatic heart damage which developed in association with urothelial bladder carcinoma in a 79-year old female patient. Various masses may be found in the heart. In tumors, a secondary damage to the heart is observed much more frequently than a primary damage; however, metastasis of bladder carcinoma to the heart is extremely rare. Of interest is the fact of metastatic damage to all layers of the heart, including the endocardium, pericardium, and myocardium.
2017: Kardiologiia
https://www.readbyqxmd.com/read/29275006/altered-myofilament-structure-and-function-in-dogs-with-duchenne-muscular-dystrophy-cardiomyopathy
#3
Younss Ait Mou, Alain Lacampagne, Thomas Irving, Valérie Scheuermann, Stéphane Blot, Bijan Ghaleh, Pieter P de Tombe, Olivier Cazorla
AIM: Duchenne Muscular Dystrophy (DMD) is associated with progressive depressed left ventricular (LV) function. However, DMD effects on myofilament structure and function are poorly understood. Golden Retriever Muscular Dystrophy (GRMD) is a dog model of DMD recapitulating the human form of DMD. OBJECTIVE: The objective of this study is to evaluate myofilament structure and function alterations in GRMD model with spontaneous cardiac failure. METHODS AND RESULTS: We have employed synchrotron X-rays diffraction to evaluate myofilament lattice spacing at various sarcomere lengths (SL) on permeabilized LV myocardium...
December 21, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29248842/group-wise-similarity-registration-of-point-sets-using-student-s-t-mixture-model-for-statistical-shape-models
#4
Nishant Ravikumar, Ali Gooya, Serkan Çimen, Alejandro F Frangi, Zeike A Taylor
A probabilistic group-wise similarity registration technique based on Student's t-mixture model (TMM) and a multi-resolution extension of the same (mr-TMM) are proposed in this study, to robustly align shapes and establish valid correspondences, for the purpose of training statistical shape models (SSMs). Shape analysis across large cohorts requires automatic generation of the requisite training sets. Automated segmentation and landmarking of medical images often result in shapes with varying proportions of outliers and consequently require a robust method of alignment and correspondence estimation...
December 5, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/29247031/endocardial-activation-drives-activation-patterns-during-long-duration-ventricular-fibrillation-and-defibrillation
#5
Nuttanont Panitchob, Li Li, Jian Huang, Ravi Ranjan, Raymond E Ideker, Derek J Dosdall
BACKGROUND: Understanding the mechanisms that drive ventricular fibrillation is essential for developing improved defibrillation techniques to terminate ventricular fibrillation (VF). Distinct organization patterns of chaotic, regular, and synchronized activity were previously demonstrated in VF that persisted over 1 to 2 minutes (long-duration VF [LDVF]). We hypothesized that activity on the endocardium may be driving these activation patterns in LDVF and that unsuccessful defibrillation shocks may alter activation patterns...
December 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29226547/avian-embryonic-coronary-arterio-venous-pattering-involves-the-contribution-of-different-endothelial-and-endocardial-cell-populations
#6
Paul Palmquist-Gomes, Juan Antonio Guadix, José M Pérez-Pomares
BACKGROUND: Coronary vasculature irrigates the myocardium and is crucial to late embryonic and adult heart function. Despite the developmental significance and clinical relevance of these blood vessels, the embryonic origin and the cellular and molecular mechanisms that regulate coronary arterio-venous patterning are not known in detail. In this study, we have used the avian embryo to dissect the ontogenetic origin and morphogenesis of coronary vasculature. RESULTS: We show that sinus venosus endocardial sprouts and proepicardial angioblasts pioneer coronary vascular formation, invading the developing heart simultaneously...
December 11, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/29223305/usefulness-of-ultra-high-resolution-mapping-for-detecting-epicardial-atrial-activation-during-mitral-isthmus-ablation
#7
Hiroki Kitajima, Yuji Nishikawa, Keitaro Senoo, Masahiro Esato
We describe a patient with perimitral atrial flutter (PMF) following the atrial fibrillation ablation and the linear ablation at the mitral isthmus (MI). From both the activation and the voltage maps using ultra-high resolution mapping, we detected the epicardial connection through the coronary sinus (CS) within the entire reentrant circuit. Point ablation within the CS, not additional linear MI ablation from the endocardium terminates PMF, with a bidirectional block across the low voltage area at the MI.
November 21, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29214787/myocardial-layer-specific-strain-analysis-in-children-with-mitochondrial-disease
#8
Lucy Youngmin Eun, Young Mock Lee
PURPOSE: Children with mitochondrial disease (MD) have clinical phenotypes that are more severe than those found in adults. In this study, we assessed cardiac function in children with MD using conventional and advanced echocardiographic measurements, explored any unique patterns present, and investigated the development of early cardiomyopathy (CMP). MATERIALS AND METHODS: We retrospectively reviewed the medical records of 33 children with MD. All patients underwent transthoracic echocardiography with conventional and advanced myocardial analysis...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29202457/recapitulation-of-developmental-mechanisms-to-revascularize-the-ischemic-heart
#9
Karina N Dubé, Tonia M Thomas, Sonali Munshaw, Mala Rohling, Paul R Riley, Nicola Smart
Restoring blood flow after myocardial infarction (MI) is essential for survival of existing and newly regenerated tissue. Endogenous vascular repair processes are deployed following injury but are poorly understood. We sought to determine whether developmental mechanisms of coronary vessel formation are intrinsically reactivated in the adult mouse after MI. Using pulse-chase genetic lineage tracing, we establish that de novo vessel formation constitutes a substantial component of the neovascular response, with apparent cellular contributions from the endocardium and coronary sinus...
November 16, 2017: JCI Insight
https://www.readbyqxmd.com/read/29197470/morphologic-findings-in-donor-transplanted-hearts-at-necropsy-early-and-late-after-orthotopic-heart-transplantation
#10
William C Roberts, Nitin Kondapalli, Joseph M Guileyardo
Little necropsy information is available on donor hearts in place in recipients for varying periods. Necropsy studies were performed in 79 patients who had survived from 1 day to 17 years after orthotopic heart transplantation (OHT). At OHT, the 79 patients ranged in age from 3 to 70 years (mean 51), and at death, from 20 to 76 years (mean 54). The native hearts tended to be larger than the donor hearts in the 22 patients surviving ≤60 days and the donor hearts tended to be larger in the 57 patients surviving >60 days, suggesting that the donor hearts increased in weight with time...
October 20, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29193078/termination-of-reentrant-atrial-tachycardia-via-optogenetic-stimulation-with-optimized-spatial-targeting-insights-from-computational-models
#11
Patrick M Boyle, Michael J Murphy, Thomas V Karathanos, Sohail Zahid, Robert C Blake, Natalia A Trayanova
Optogenetics has emerged as a potential alternative to electrotherapy for treating arrhythmia, but feasibility studies have been limited to ventricular defibrillation via epicardial light application. Here, we assess the efficacy of optogenetic atrial tachycardia (AT) termination in human hearts using a strategy that targets for illumination specific regions identified in an automated manner. In three patient-specific models reconstructed from late gadolinium-enhanced MRI scans, we simulated channelrhodopsin-2 (ChR2) expression via gene delivery...
November 28, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29188099/serial-optical-coherence-scanning-reveals-an-association-between-cardiac-function-and-the-heart-architecture-in-the-aging-rodent-heart
#12
Alexandre Castonguay, Joël Lefebvre, Philippe Pouliot, Pramod Avti, Mohammad Moeini, Frédéric Lesage
Normal aging is accompanied by structural changes in the heart architecture. To explore this remodeling, we used a serial optical coherence tomography scanner to image entire mouse hearts at micron scale resolution. Ex vivo hearts of 7 young (4 months) and 5 old (24 months) C57BL/6 mice were acquired with the imaging platform. OCT of the myocardium revealed myofiber orientation changing linearly from the endocardium to the epicardium. In old mice, this rate of change was lower when compared to young mice while the average volume of old mice hearts was significantly larger (p<0...
November 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/29187724/in-depth-insight-into-the-mechanisms-of-cardiac-dysfunction-in-patients-with-childhood-cancer-after-anthracycline-treatment-using-layer-specific-strain-analysis
#13
Kana Yazaki, Ken Takahashi, Sachie Shigemitsu, Mariko Yamada, Takeshi Iso, Maki Kobayashi, Katsumi Akimoto, Hiroyuki Tamaichi, Junya Fujimura, Masahiro Saito, Masaki Nii, Toshiaki Shimizu
BACKGROUND: Anthracycline cardiotoxicity affects clinical outcomes, and its early detection using methods that rely on conventional echocardiography, such as left ventricular ejection fraction (LVEF) is difficult. This study aimed to evaluate the characteristics and the differences in cardiac dysfunction among childhood cancer survivors in 3 age groups using layer-specific strain analysis in a wide age range.Methods and Results:The 56 patients (median age: 15 [range: 6.8-40.2] years) who had been treated with anthracycline for childhood cancer were divided into 3 age groups (C1: 6-12 years, C2: 13-19 years, C3: 20-40 years) after anthracycline treatment, and 72 controls of similar ages were divided into 3 corresponding groups (N1, N2, and N3)...
November 29, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29187205/combined-double-chambered-right-ventricle-tricuspid-valve-dysplasia-ventricular-septal-defect-and-subaortic-stenosis-in-a-dog
#14
Iuliu Scurtu, Flaviu Tabaran, Mircea Mircean, Gavril Giurgiu, Andras Nagy, Cornel Catoi, Dan G Ohad
BACKGROUND: Double chambered right ventricle (DCRV) is a congenital heart anomaly where the right ventricle is divided into two chambers. We describe, for the first time, an unusual combination of DCRV combined with some other congenital heart defects. CASE PRESENTATION: A 1.2-year-old Golden Retriever was presented with lethargy, exercise intolerance and ascites. Physical examination revealed an irregularly irregular pulse and a grade V/VI, systolic, right cranial murmur...
November 29, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29182657/accuracy-and-reproducibility-of-ct-right-to-left-ventricular-diameter-measurement-in-patients-with-acute-pulmonary-embolism
#15
Yvonne M Ende-Verhaar, Lucia J M Kroft, Inge C M Mos, Menno V Huisman, Frederikus A Klok
BACKGROUND: Right ventricular (RV) dysfunction caused by acute pulmonary embolism (PE) is associated with poor short- and long-term prognosis. RV dilatation as a proxy for RV dysfunction can be assessed by calculating the right-to-left ventricle diameter (RV/LV) ratio on standard computed tomography pulmonary angiography (CTPA) images. It is unknown whether dedicated training is required to accurately and reproducibly measure RV/LV ratio therefore we aimed to assess these parameters in residents in internal medicine without experience in CTPA reading...
2017: PloS One
https://www.readbyqxmd.com/read/29171965/fibrotic-infarction-on-the-lv-free-wall-may-alter-the-mechanics-of-healthy-septal-wall-during-passive-filling
#16
Fulufhelo Nemavhola
The effect of myocardial infarction on the global functioning of the heart is well known. Less is understood regarding the effect of LV fibrotic infarction on the cardiac mechanics of the septal wall. To determine this unknown, the stress and strain of septal wall on the healthy and infarcted rat heart model is measured by using finite element models of rat heart geometries. The main objective of this study was to utilized computational methods to study the effect of LV free wall fibrotic infarction on the healthy septal wall...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/29170757/human-pluripotent-stem-cell-derived-epicardial-progenitors-can-differentiate-to-endocardial-like-endothelial-cells
#17
Xiaoping Bao, Vijesh J Bhute, Tianxiao Han, Tongcheng Qian, Xiaojun Lian, Sean P Palecek
During heart development, epicardial progenitors contribute various cardiac lineages including smooth muscle cells, cardiac fibroblasts, and endothelial cells. However, their specific contribution to the human endothelium has not yet been resolved, at least in part due to the inability to expand and maintain human primary or pluripotent stem cell (hPSC)-derived epicardial cells. Here we first generated CDH5-2A-eGFP knock-in hPSC lines and differentiated them into self-renewing WT1+ epicardial cells, which gave rise to endothelial cells upon VEGF treatment in vitro...
June 2017: Bioengineering & Translational Medicine
https://www.readbyqxmd.com/read/29169623/endocardial-peripheral-nerve-sheath-tumour-with-features-of-a-benign-schwannoma-in-a-donkey
#18
G Paraschou, A Suárez-Bonnet, V Grove, S L Priestnall
A peripheral nerve sheath tumour, with features of a benign schwannoma and arising from the endocardium of the right ventricle, was found incidentally during routine post-mortem examination of a 28-year-old gelding donkey. Macroscopically, five round to oval, white to grey and red, firm masses, firmly attached to the endocardium were identified. Microscopically, the endocardium and adjacent subendocardium were infiltrated by a variably demarcated, non-encapsulated mesenchymal neoplasm with features of a benign schwannoma, including concurrent presence of Antoni A and Antoni B areas, nuclear palisading, neoplastic cells with enlarged bizarre nuclei ('ancient change') and the formation of Verocay-like bodies...
November 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/29164584/cardiac-magnetic-resonance-in-systemic-sclerosis-patients-with-cardiac-symptoms
#19
A Meduri, D V Di Molfetta, L Natale, R Manfredi
OBJECTIVE: Systemic sclerosis (SSc) is characterized by widespread vascular lesions and skin and internal organs fibrosis, including the heart; all cardiac layers, endocardium, myocardium, and pericardium, may be involved. We report the relevance of cardiac MRI findings in scleroderma patients with cardiac symptoms. PATIENTS AND METHODS: 50 patients, all fulfilling the ACR SSc criteria (19 with limited and 31 with diffused skin involvement) were evaluated using a 1...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29162896/%C3%AE-adrenergic-stimulation-augments-transmural-dispersion-of-repolarization-via-modulation-of-delayed-rectifier-currents-iks-and-ikr-in-the-human-ventricle
#20
C Kang, A Badiceanu, J A Brennan, C Gloschat, Y Qiao, N A Trayanova, I R Efimov
Long QT syndrome (LQTS) is an inherited or drug induced condition associated with delayed repolarization and sudden cardiac death. The cardiac potassium channel, IKr, and the adrenergic-sensitive cardiac potassium current, IKs, are two primary contributors to cardiac repolarization. This study aimed to elucidate the role of β-adrenergic (β-AR) stimulation in mediating the contributions of IKr and IKs to repolarizing the human left ventricle (n = 18). Optical mapping was used to measure action potential durations (APDs) in the presence of the IKs blocker JNJ-303 and the IKr blocker E-4031...
November 21, 2017: Scientific Reports
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