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Stage 4 prostate cancer

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https://www.readbyqxmd.com/read/28736322/clinical-outcomes-of-chemotherapy-na%C3%A3-ve-men-with-metastatic-castration-resistant-prostate-cancer-and-low-baseline-psa-treated-with-enzalutamide-vs-placebo
#1
Mary-Ellen Taplin, Andrew J Armstrong, Ping Lin, Andrew Krivoshik, De Phung, Teresa Parli, Bertrand Tombal, Tomasz M Beer
PURPOSE: Metastatic castration-resistant prostate cancer with low baseline prostate-specific antigen represents an early stage in the natural history of castration-resistant prostate cancer disease progression (low-volume disease), low prostate-specific antigen-producing disease, or disease less dependent on androgen receptor biology (high-volume disease). We analyzed outcomes in men with low prostate-specific antigen and high disease burden who received the oral androgen-receptor inhibitor enzalutamide in the PREVAIL study...
July 20, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28736250/change-in-prostate-cancer-presentation-coinciding-with-uspstf-screening-recommendations-at-a-community-based-urology-practice
#2
Franklin D Gaylis, Jae E Choi, Zachary Hamilton, Paul Dato, Edward Cohen, Renee Calabrese, Hilary Prime, Aaron Rosenbaum, Andrew Karim Kader
OBJECTIVE: The benefits of prostate-specific antigen (PSA)-based prostate cancer screening are controversial. We sought to determine the change in prostate cancer presentation coinciding with the release of the United States Preventative Services Task Force recommendations against screening in a high-volume community-based urology practice. METHODS: Characteristics of men presenting for an elevated PSA at a community urology practice from August 2011 to August 2015 were queried from a prospectively collected database...
July 20, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28734019/association-between-androgen-deprivation-therapy-and-anxiety-among-78-000-patients-with-localized-prostate-cancer
#3
Kathryn T Dinh, David D Yang, Kevin T Nead, Gally Reznor, Quoc-Dien Trinh, Paul L Nguyen
OBJECTIVES: To examine whether any androgen deprivation therapy use or longer duration is associated with an increased risk of anxiety in patients with prostate cancer. METHODS: We identified 78 552 men aged ≥66 years with stage I-III prostate cancer using the Surveillance, Epidemiology, and End Results-Medicare linked database from 1992 to 2006, excluding patients with psychiatric diagnoses within the year prior or 6 months after prostate cancer diagnosis. Multivariable Cox regression was used to examine the association between pharmacological androgen deprivation therapy and diagnosis of anxiety...
July 22, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28727544/abbreviated-biparametric-prostate-mr-imaging-in-men-with-elevated-prostate-specific-antigen
#4
Christiane K Kuhl, Robin Bruhn, Nils Krämer, Sven Nebelung, Axel Heidenreich, Simone Schrading
Purpose To determine the diagnostic accuracy for clinically significant prostate cancer achieved with abbreviated biparametric prostate magnetic resonance (MR) imaging in comparison with full multiparametric contrast material-enhanced prostate MR imaging in men with elevated prostate-specific antigen (PSA) and negative transrectal ultrasonography (US)-guided biopsy findings; to determine the significant cancer detection rate of biparametric versus full multiparametric contrast-enhanced MR imaging and between-reader agreement for interpretation of biparametric MR imaging...
July 20, 2017: Radiology
https://www.readbyqxmd.com/read/28720374/the-4kscore-predicts-the-grade-and-stage-of-prostate-cancer-in-the-radical-prostatectomy-specimen-results-from-a-multi-institutional-prospective-trial
#5
Sanoj Punnen, Bruno Nahar, Nachiketh S Prakash, Daniel D Sjoberg, Stephen M Zappala, Dipen J Parekh
BACKGROUND: The 4Kscore accurately predicts aggressive prostate cancer (PCa) on prostate biopsy. OBJECTIVE: We assessed how well the 4Kscore predicts pathology at radical prostatectomy (RP). DESIGN, SETTING, AND PARTICIPANTS: Among 1312 men who prospectively underwent a 4Kscore and biopsy of the prostate at 26 sites throughout the United States from October 2013 to April 2014, we selected men who were diagnosed with cancer and underwent RP...
February 2017: European Urology Focus
https://www.readbyqxmd.com/read/28715534/the-association-between-vasectomy-and-prostate-cancer-a-systematic-review-and-meta-analysis
#6
Bimal Bhindi, Christopher J D Wallis, Madhur Nayan, Ann M Farrell, Landon W Trost, Robert J Hamilton, Girish S Kulkarni, Antonio Finelli, Neil E Fleshner, Stephen A Boorjian, R Jeffrey Karnes
Importance: Despite 3 decades of study, there remains ongoing debate regarding whether vasectomy is associated with prostate cancer. Objective: To determine if vasectomy is associated with prostate cancer. Data Sources: The MEDLINE, EMBASE, Web of Science, and Scopus databases were searched for studies indexed from database inception to March 21, 2017, without language restriction. Study Selection: Cohort, case-control, and cross-sectional studies reporting relative effect estimates for the association between vasectomy and prostate cancer were included...
July 17, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28710901/baseline-and-longitudinal-plasma-caveolin-1-level-as-a-biomarker-in-active-surveillance-for-early-stage-prostate-cancer
#7
Spyridon P Basourakos, John W Davis, Brian F Chapin, John F Ward, Curtis A Pettaway, Louis L Pisters, Neema Navai, Mary F Achim, Xuemei Wang, Hsiang-Chun Chen, Seungtaek Choi, Deborah Kuban, Patricia Troncoso, Sam Hanash, Timothy C Thompson, Jeri Kim
OBJECTIVES: To evaluate the role of caveolin-1 as a predictor of disease reclassification in men with early prostate cancer undergoing active surveillance. PATIENTS AND METHODS: We analyzed archived plasma samples prospectively collected from men with early prostate cancer in a single-institution active surveillance study. Of 825 patients enrolled, 542 had 1 or more years of follow-up. Baseline and longitudinal plasma caveolin-1 levels were measured using an enzyme-linked immunosorbent assay...
July 15, 2017: BJU International
https://www.readbyqxmd.com/read/28700821/gene-expression-profiling-of-prostate-tissue-identifies-chromatin-regulation-as-a-potential-link-between-obesity-and-lethal-prostate-cancer
#8
Ericka M Ebot, Travis Gerke, David P Labbé, Jennifer A Sinnott, Giorgia Zadra, Jennifer R Rider, Svitlana Tyekucheva, Kathryn M Wilson, Rachel S Kelly, Irene M Shui, Massimo Loda, Philip W Kantoff, Stephen Finn, Matthew G Vander Heiden, Myles Brown, Edward L Giovannucci, Lorelei A Mucci
BACKGROUND: Obese men are at higher risk of advanced prostate cancer and cancer-specific mortality; however, the biology underlying this association remains unclear. This study examined gene expression profiles of prostate tissue to identify biological processes differentially expressed by obesity status and lethal prostate cancer. METHODS: Gene expression profiling was performed on tumor (n = 402) and adjacent normal (n = 200) prostate tissue from participants in 2 prospective cohorts who had been diagnosed with prostate cancer from 1982 to 2005...
July 12, 2017: Cancer
https://www.readbyqxmd.com/read/28693295/germline-dna-copy-number-variations-as-potential-prognostic-markers-for-non-muscle-invasive-bladder-cancer-progression
#9
Yoshiaki Yamamoto, Yutaka Suehiro, Atomu Suzuki, Ryosuke Nawata, Yoshihisa Kawai, Ryo Inoue, Hiroshi Hirata, Hiroaki Matsumoto, Takahiro Yamasaki, Kohsuke Sasaki, Hideyasu Matsuyama
Accumulating evidence has suggested that germline DNA copy number variations (CNVs) affect various disorders, including human malignancies. However, the significance of CNVs in non-muscle invasive bladder cancer (NMIBC) remains unclear. The purpose of the present study was to identify the role of CNVs in NMIBC. Array comparative genomic hybridization (CGH) analysis was performed to search for candidate CNVs associated with NMIBC susceptibility. Quantitative polymerase chain reaction was carried out to evaluate CNVs associated with patient outcome in 189 NMIBC cases...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28689518/colon-cancer-screening-is-it-time-yet
#10
EDITORIAL
Hadi Bhurgri, Sami Samiullah
The month of March is dedicated to Colon Cancer Awareness. Worldwide, colorectal cancer (CRC) incidence has been on the rise. It is currently the third most common cancer in men (746,000 cases, 10.0% of the total) and the second in women (614,000 cases, 9.2% of the total).1 Arecent meta-analysis reported a 61% risk reduction in CRC incidence with colonoscopy.2 Unlike screening programs for breast and prostate cancers, not only has CRC screening reduced mortality from colon cancer and detected early CRC, it has also decreased the incidence of CRC through detection and removal of pre-cancerous lesions...
June 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28687398/the-impact-of-comorbidities-on-the-benefits-of-prolonged-androgen-ablation-in-patients-with-t3-4-prostate-cancer-treated-with-external-beam-radiation-therapy
#11
Eric Tran, Matthew Paquette, Justin Jay, Jeremy Hamm, Mitchell Liu, Graeme Duncan, Tom Pickles, Scott Tyldesley
PURPOSE: To determine whether the survival benefit associated with prolonged androgen deprivation therapy (ADT) and radiotherapy (EBRT) varies with baseline estimates of overall survival in cT3-4 prostate cancer patients (PCa). METHODS AND MATERIALS: In 1997, the BC Cancer Agency adopted as standard a policy of prolonged ADT (>18months) with EBRT for locally advanced PCa. Two cohorts of cT3-T4 PCa treated with EBRT were selected: 1993-1995 (early: N=725) and 1999-2001 (late: N=584)...
July 4, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28680067/normalized-periprostatic-fat-mri-measurements-can-predict-prostate-cancer-aggressiveness-in-men-undergoing-radical-prostatectomy-for-clinically-localised-disease
#12
Naief Dahran, Magdalena Szewczyk-Bieda, Cheng Wei, Sarah Vinnicombe, Ghulam Nabi
Periprostatic and pelvic fat have been shown to influence prostate cancer behaviour through the secretion of chemokines and growth factors, acting in a paracrine mode. We have measured periprostatic fat volume (PFV) with normalisation to prostate gland volume on pelvic magnetic resonance imaging (MRI) and have correlated this with grade (Gleason score; GS) and pathological staging (pT) of prostate cancer (PCa) following radical prostatectomy (RP). PFV was determined using a segmentation technique on contiguous T1-weighted axial MRI slices from the level of the prostate base to the apex...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28676103/pre-diagnostic-metabolite-concentrations-and-prostate-cancer-risk-in-1077-cases-and-1077-matched-controls-in-the-european-prospective-investigation-into-cancer-and-nutrition
#13
Julie A Schmidt, Georgina K Fensom, Sabina Rinaldi, Augustin Scalbert, Paul N Appleby, David Achaintre, Audrey Gicquiau, Marc J Gunter, Pietro Ferrari, Rudolf Kaaks, Tilman Kühn, Anna Floegel, Heiner Boeing, Antonia Trichopoulou, Pagona Lagiou, Eleutherios Anifantis, Claudia Agnoli, Domenico Palli, Morena Trevisan, Rosario Tumino, H Bas Bueno-de-Mesquita, Antonio Agudo, Nerea Larrañaga, Daniel Redondo-Sánchez, Aurelio Barricarte, José Maria Huerta, J Ramón Quirós, Nick Wareham, Kay-Tee Khaw, Aurora Perez-Cornago, Mattias Johansson, Amanda J Cross, Konstantinos K Tsilidis, Elio Riboli, Timothy J Key, Ruth C Travis
BACKGROUND: Little is known about how pre-diagnostic metabolites in blood relate to risk of prostate cancer. We aimed to investigate the prospective association between plasma metabolite concentrations and risk of prostate cancer overall, and by time to diagnosis and tumour characteristics, and risk of death from prostate cancer. METHODS: In a case-control study nested in the European Prospective Investigation into Cancer and Nutrition, pre-diagnostic plasma concentrations of 122 metabolites (including acylcarnitines, amino acids, biogenic amines, glycerophospholipids, hexose and sphingolipids) were measured using targeted mass spectrometry (AbsoluteIDQ p180 Kit) and compared between 1077 prostate cancer cases and 1077 matched controls...
July 5, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28673277/impact-of-a-protein-based-assay-that-predicts-prostate-cancer-aggressiveness-on-urologists-recommendations-for-active-treatment-or-active-surveillance-a-randomized-clinical-utility-trial
#14
John W Peabody, Lisa M DeMaria, Diana Tamondong-Lachica, Jhiedon Florentino, M Czarina Acelajado, Othman Ouenes, Jerome P Richie, Trever Burgon
BACKGROUND: Of the more than 1.1 million men diagnosed worldwide annually with prostate cancer, the majority have indolent tumors. Distinguishing between aggressive and indolent cancer is an important clinical challenge. The current approaches for assessing tumor aggressiveness are recognized as insufficient. A validated protein-based assay has been shown to predict tumor aggressiveness from prostate biopsy. The main objective of this study was to measure the clinical utility of this new assay in the management of early-stage prostate cancer...
July 3, 2017: BMC Urology
https://www.readbyqxmd.com/read/28669765/independent-validation-of-the-american-joint-committee-on-cancer-8th-edition-prostate-cancer-staging-classification
#15
Bimal Bhindi, R Jeffrey Karnes, Laureano J Rangel, Ross J Mason, Matthew T Gettman, Igor Frank, Matthew K Tollefson, Daniel W Lin, R Houston Thompson, Stephen A Boorjian
PURPOSE: We sought to independently validate the American Joint Committee on Cancer (AJCC) 8(th) edition prostate cancer (PCa) staging classification, which includes the elimination of pT2 subcategories and the reclassification of patients with PSA≥20ng/ml and Gleason Grade Group (GG)-5 as Stage Group III-A and III-C, respectively. MATERIALS AND METHODS: Men who underwent radical prostatectomy at Mayo Clinic between 1987-2011 (n=13,839) were identified from our institutional registry...
June 29, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28667448/adjuvant-versus-salvage-radiotherapy-in-prostate-cancer-multi-institutional-retrospective-analysis-of-the-spanish-recap-database
#16
A Hervás, A Gómez-Caamaño, M Casaña, A Gómez-Iturriaga, J Pastor, J Jove, J L Mengual, C Gónzalez-San Segundo, J Muñoz
PURPOSE: To compare adjuvant radiotherapy (ART) to salvage radiotherapy (SRT) after radical prostatectomy (RP) in a cohort of prostate cancer (PCa) patients. The primary aim was to comparatively assess 2- and 5-year biochemical relapse-free survival (BRFS). A secondary aim was to identify predictors of survival. PATIENTS AND METHODS: Data were acquired from the RECAP database, a population-based prostate cancer registry in Spain. Inclusion criteria included RP (with or without lymphadenectomy) followed by ART or SRT...
June 30, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28662291/validation-of-the-2015-prostate-cancer-grade-groups-for-predicting-long-term-oncologic-outcomes-in-a-shared-equal-access-health-system
#17
Ariel A Schulman, Lauren E Howard, Kae Jack Tay, Efrat Tsivian, Christina Sze, Christopher L Amling, William J Aronson, Matthew R Cooperberg, Christopher J Kane, Martha K Terris, Stephen J Freedland, Thomas J Polascik
BACKGROUND: A 5-tier prognostic grade group (GG) system was enacted to simplify the risk stratification of patients with prostate cancer in which Gleason scores of ≤6, 3 + 4, 4 + 3, 8, and 9 or 10 are considered GG 1 through 5, respectively. The authors investigated the utility of biopsy GG for predicting long-term oncologic outcomes after radical prostatectomy in an equal-access health system. METHODS: Men who underwent prostatectomy at 1 of 6 Veterans Affairs hospitals in the Shared Equal Access Regional Cancer Hospital database between 2005 and 2015 were reviewed...
June 29, 2017: Cancer
https://www.readbyqxmd.com/read/28656603/a-genetic-variant-near-gata3-implicated-in-inherited-susceptibility-and-etiology-of-benign-prostatic-hyperplasia-bph-and-lower-urinary-tract-symptoms-luts
#18
Rong Na, Brian T Helfand, Haitao Chen, Carly A Conran, Susan E Crawford, Simon W Hayward, Teuvo L J Tammela, Judy Hoffman-Bolton, Siqun L Zheng, Patrick C Walsh, Johanna Schleutker, Elizabeth A Platz, William B Isaacs, Jianfeng Xu
BACKGROUND: Benign prostatic hyperplasia (BPH) and associated lower urinary tract symptoms (LUTS) are common conditions. Little is known about their etiologies except that studies have suggested a substantial heritable component. Our objective is to provide a comprehensive, genome-wide evaluation of inherited risks and possible mechanisms of etiology in BPH. METHODS: We performed a three-stage, genome-wide association study (GWAS) of men from three independent populations, the REduction by DUtasteride of prostate Cancer Events (REDUCE) trial, the CLUE II cohort, and a Finnish hospital-based population...
June 28, 2017: Prostate
https://www.readbyqxmd.com/read/28654336/focal-therapy-for-prostate-cancer-with-in-bore-mr-guided-focused-ultrasound-two-year-follow-up-of-a-phase-i-trial-complications-and-functional-outcomes
#19
Kae Jack Tay, Christopher W S Cheng, Weber K O Lau, James Khoo, Choon Hua Thng, Jin Wei Kwek
Purpose To report the safety profile and 2-year functional outcomes of in-bore magnetic resonance (MR)-guided focused ultrasound on single cancer foci in men with prostate cancer. Materials and Methods Ethics approval was obtained from the centralized institutional review board for this prospective single-arm study, and patients provided informed consent. Patients with untreated low-volume low-grade prostate cancer (clinical stage T2a or lower; Gleason score, 3+3; index tumor ≤10 mm(3)) underwent MR-guided focused ultrasound between July 2011 and February 2013...
June 26, 2017: Radiology
https://www.readbyqxmd.com/read/28637799/-68-ga-psma-pet-ct-and-volumetric-morphology-of-pet-positive-lymph-nodes-stratified-by-tumor-differentiation-of-prostate-cancer
#20
Maria Vinsensia, Peter L Choyke, Boris Hadaschik, Tim Holland-Letz, Jan Moltz, Klaus Kopka, Isabel Rauscher, Walter Mier, Markus Schwaiger, Uwe Haberkorn, Tobias Maurer, Clemens Kratochwil, Matthias Eiber, Frederik Giesel
(68)Ga prostate specific membrane antigen (PSMA) positron emission tomography (PET)/computer tomography (CT) is a new method to detect early nodal metastases in patients with biochemical relapse of prostate cancer (PCa). In this retrospective investigation the dimensions, volume, localization and maximum standardized uptake value (SUVmax) of nodes identified by (68)Ga-PSMA were correlated to their Gleason score (GS) at diagnosis. Methods: All PET/CT images were acquired 60±10 min after intravenous injection of (68)Ga-PSMA (mean dose 176 MBq)...
June 21, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
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