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https://www.readbyqxmd.com/read/29777523/application-of-cu-64-nodaga-psma-pet-in-prostate-cancer
#1
Sabina Sevcenco, Hans Christoph Klingler, Klaus Eredics, Alexander Friedl, Jenifer Schneeweiss, Peter Knoll, Thomas Kunit, Lukas Lusuardi, Siroos Mirzaei
INTRODUCTION: The high diagnostic potential of 64 Cu-PSMA PET-CT imaging was clinically investigated in prostate cancer patients with recurrent disease and in the primary staging of selected patients with advanced local disease. The aim of our study is to assess the uptake behavior in the clinical setting of 64Copper Prostate-Specific Membrane Antigen (64 Cu PSMA) Positron Emission Tomography/Computed Tomography (PET/CT) in prostate cancer. METHODS: A retrospective study was performed in 23 patients with intermediate, high risk and progressive disease at primary staging of prostate cancer...
May 17, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29757368/the-long-noncoding-rna-landscape-of-neuroendocrine-prostate-cancer-and-its-clinical-implications
#2
Varune Rohan Ramnarine, Mohammed Alshalalfa, Fan Mo, Noushin Nabavi, Nicholas Erho, Mandeep Takhar, Robert Shukin, Sonal Brahmbhatt, Alexander Gawronski, Maxim Kobelev, Mannan Nouri, Dong Lin, Harrison Tsai, Tamara L Lotan, R Jefferey Karnes, Mark A Rubin, Amina Zoubeidi, Martin E Gleave, Cenk Sahinalp, Alexander W Wyatt, Stanislav V Volik, Himisha Beltran, Elai Davicioni, Yuzhuo Wang, Colin C Collins
Background: Treatment induced neuroendocrine prostate cancer (tNEPC) is an aggressive variant of late-stage metastatic castrate resistant (mCRPC) prostate cancer that commonly arises through neuroendocrine transdifferentiation (NEtD). Treatment options are limited, ineffective, and for most patients, results in death in less than a year. We previously developed a first-in-field patient-derived xenograft (PDX) model of NEtD. Longitudinal deep transcriptome profiling of this model enabled monitoring of dynamic transcriptional changes during NEtD and in the context of androgen deprivation...
May 10, 2018: GigaScience
https://www.readbyqxmd.com/read/29755671/should-reporting-of-peri-neural-invasion-and-extra-prostatic-extension-be-mandatory-in-prostate-cancer-biopsies-correlation-with-outcome-in-biopsy-cases-treated-conservatively
#3
Amar S Ahmad, Vishnu Parameshwaran, Luis Beltran, Gabrielle Fisher, Bernard V North, David Greenberg, Geraldine Soosay, Henrik Møller, Peter Scardino, Jack Cuzick, Daniel M Berney
The identification of perineural invasion (PNI) and extraprostatic extension (ECE) in prostate cancer (PC) biopsies is time consuming and can be difficult. Although this is required information in many datasets, there is little evidence on their effect on outcome in patients treated conservatively. Cases of PC were identified from three cancer registries in the UK from men with clinically localized prostate cancer diagnosed by needle biopsy from 1990-2003. The endpoint was prostate cancer death (DOD). Patients treated radically within 6 months, those with objective evidence of metastases or who had prior hormone therapy were excluded...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29752141/predictors-of-falls-in-older-survivors-of-breast-and-prostate-cancer-a-retrospective-cohort-study-of-surveillance-epidemiology-and-end-results-medicare-health-outcomes-survey-linkage
#4
Min H Huang, Jennifer Blackwood, Monica Godoshian, Lucinda Pfalzer
OBJECTIVES: To identify predictors of falls in older breast and prostate cancer survivors. METHODS: This retrospective cohort study analyzed population-based Surveillance, Epidemiology and End Results-Medicare Health Outcomes Survey (SEER-MHOS) linkage. Inclusion criteria were age >65 years at cancer diagnosis, first primary female breast or prostate cancer, cancer staging information available, completion of baseline MHOS during years 2-3 and follow-up MHOS during years 4-5 post-diagnosis, and falls information available...
May 8, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29750539/short-term-high-precision-radiotherapy-for-early-prostate-cancer-with-concomitant-boost-to-the-dominant-lesion-ad-interim-analysis-and-preliminary-results-of-phase-ii-trial-airc-ig-13218
#5
Giorgia Timon, Delia Ciardo, Alessia Bazani, Giulia Marvaso, Giulia Riva, Stefania Volpe, Stefania Volpe, Giuseppe Renne, Giuseppe Petralia, Dario Zerini, Damaris Patricia Rojas, Samantha Dicuonzo, Davide Maestri, Floriana Pansini, Raffaella Cambria, Cristiana Fodor, Federica Cattani, Federica Golino, Valerio Scroffi, Daniela De Lorenzo, Ottavio De Cobelli, Roberto Orecchia, Barbara Alicja Jereczek-Fossa
OBJECTIVE: To report preliminary results of a cutting edge extreme hypofractionated treatment with concomitant boost to the dominant lesion for patients with early stage prostate cancer (PCa). METHODS: AIRC-IG-13218 is a prospective phase II trial started in June 2015. Patients with low and intermediate risk PCa who met the inclusion criteria underwent extreme hypofractionated radiotherapy to the prostate (36.25 Gy in 5 fractions) and a simultaneous integrated boost to the dominant intraprostatic lesion (DIL) to 37...
May 11, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29748619/eukaryotic-translation-initiation-factor-4-gamma-1-eif4g1-is-upregulated-during-prostate-cancer-progression-and-modulates-cell-growth-and-metastasis
#6
Praveen Kumar Jaiswal, Sweaty Koul, Prakash S T Shanmugam, Hari K Koul
eIF4G1, a critical component of the eIF4F complex, is required for cap-dependent mRNA translation, a process necessary for tumor growth and survival. However, the role of eIF4G1 has not been evaluated in Prostate Cancer (PCa). We observed an increased eIF4G1 protein levels in PCa tissues as compared to normal tissues. Analysis of the TCGA data revealed that eIF4G1 gene expression positively correlated with higher tumor grade and stage. Furthermore, eIF4G1 was over-expressed and or amplified, in 16% patients with metastatic PCa (SU2C/PCF Dream Team dataset) and in 59% of castration-resistant prostate cancer (CRPC) patients (Trento/Cornell/Broad dataset)...
May 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29743042/predictors-of-adverse-pathologic-features-after-radical-prostatectomy-in-low-risk-prostate-cancer
#7
Jae Won Park, Dong Hoon Koh, Won Sik Jang, Kang Su Cho, Won Sik Ham, Koon Ho Rha, Sung Joon Hong, Young Deuk Choi
BACKGROUND: Prostate-specific antigen (PSA) screening more frequently detects early stage prostate cancer (PC). However, adverse pathologic features (APFs) after radical prostatectomy (RP) in low-risk PC occur. Previous related studies had utilized outdated staging criteria or small sample cohorts. In this study, we analyzed predictors of APFs after RP in low-risk PC using classification under the current criteria. MATERIALS AND METHODS: We retrospectively reviewed medical records of 546 low-risk PC patients who had undergone RP...
May 9, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29740203/olfactomedin-4-in-digestive-diseases-a-mini-review
#8
REVIEW
Xin-Yu Wang, Sheng-Hui Chen, Ya-Nan Zhang, Cheng-Fu Xu
Olfactomedin-4 (OLFM4, GW112, hGC-1) is a glycoprotein belonging to the olfactomedin family. The expression of OLFM4 is strong in the small intestine, colon and prostate, and moderate in the stomach and bone marrow. Previous studies have revealed that OLFM4 is closely associated with many digestive diseases. Up-regulation of OLFM4 has been detected in the Helicobacter pylori ( H. pylori )-infected gastric mucosa, inflammatory bowel disease tissue and gastrointestinal malignancies, including gastric cancer, colorectal cancer, pancreatic cancer and gallbladder cancer...
May 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29737495/body-mass-index-is-an-independent-predictor-of-clavien-dindo-grade-3-complications-in-patients-undergoing-robot-assisted-radical-prostatectomy-with-extensive-pelvic-lymph-node-dissection
#9
Antonio Benito Porcaro, Marco Sebben, Alessandro Tafuri, Nicolò de Luyk, Paolo Corsi, Tania Processali, Marco Pirozzi, Riccardo Rizzetto, Nelia Amigoni, Daniele Mattevi, Maria A Cerruto, Matteo Brunelli, Giovanni Novella, Vincenzo De Marco, Filippo Migliorini, Walter Artibani
Robot assisted radical prostatectomy (RARP) with extensive pelvic lymph node dissection (ePLND) is an effective procedure for treating and staging prostate cancer; however, high grade complications represent a critical issue. To investigate clinical factors associated with the risk of Clavien-Dindo grade 3 complications in patients undergoing RARP with ePLND. The study included 211 consecutive patients who were operated in a period running from June 2013 to March 2017. Factors associated with grade 3 complications were evaluated by the logistic regression model...
May 8, 2018: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/29736376/a-rare-case-of-isolated-castrate-resistant-bilateral-testicular-metastases-in-advanced-prostate-cancer
#10
Jiarui Su, Edwin Jonathan Aslim, Hakan Aydin, Puay Hoon Tan, Henry Sun Sien Ho
Testicular metastasis is rare with the prostate being the most common site of primary cancer. We report a case of a 72-year-old man with castration-resistant prostate cancer (CRPC) and known metastases to bone and lymph nodes, who developed bilateral painful swollen testes 3 years after the initial diagnosis of prostate cancer. He had first presented with lower urinary tract symptoms (LUTS) with suspicious findings on digital rectal examination of the prostate, and an elevated serum prostate specific antigen (PSA) level of 129 ng/mL...
April 2018: Asian Journal of Urology
https://www.readbyqxmd.com/read/29735368/changing-incidence-of-metastatic-prostate-cancer-by-race-and-age-1988-2015
#11
Marc A Dall'Era, Ralph deVere-White, Danielle Rodriguez, Rosemary Cress
BACKGROUND: Screening for prostate cancer (PCa) has dramatically declined in the United States (US) since the United States Preventive Services Task Force recommended against routine prostate-specific antigen (PSA)-based PCa screening in all men in 2012. This led to dramatic reductions in the diagnosis of localized disease across all clinical risk groups. OBJECTIVE: In light of decreased PSA screening for men in the US, we sought to study trends in newly diagnosed metastatic PCa incidence and how this may vary by race and age...
May 4, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29734878/pelvic-lymph-node-dissection-in-prostate-cancer-staging-evaluation-of-morbidity-and-oncological-outcomes
#12
Andries Van Huele, Filip Poelaert, Valérie Fonteyne, Karel Decaestecker, Piet Ost, Nicolaas Lumen
BACKGROUND: To evaluate the morbidity of different surgical approaches for pelvic lymph node dissection (PLND), to evaluate the influence of morbidity on radiotherapy (RT) planning and to evaluate a possible therapeutic effect of a more extensive yield of PLND. METHODS: From 2000-2016, 228 patients received staging PLND before primary RT in a single tertiary care center. Nine patients were excluded for the evaluation of morbidity. Fifty patients were operated in an open approach, 96 laparoscopic and 73 robot-assisted (RA)...
May 8, 2018: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/29734647/recent-advances-in-prostate-cancer-treatment-and-drug-discovery
#13
REVIEW
Ekaterina Nevedomskaya, Simon J Baumgart, Bernard Haendler
Novel drugs, drug sequences and combinations have improved the outcome of prostate cancer in recent years. The latest approvals include abiraterone acetate, enzalutamide and apalutamide which target androgen receptor (AR) signaling, radium-223 dichloride for reduction of bone metastases, sipuleucel-T immunotherapy and taxane-based chemotherapy. Adding abiraterone acetate to androgen deprivation therapy (ADT) in order to achieve complete androgen blockade has proven highly beneficial for treatment of locally advanced prostate cancer and metastatic hormone-sensitive prostate cancer (mHSPC)...
May 4, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29734484/radiomic-features-from-pretreatment-biparametric-mri-predict-prostate-cancer-biochemical-recurrence-preliminary-findings
#14
Rakesh Shiradkar, Soumya Ghose, Ivan Jambor, Pekka Taimen, Otto Ettala, Andrei S Purysko, Anant Madabhushi
BACKGROUND: Radiomics or computer-extracted texture features derived from MRI have been shown to help quantitatively characterize prostate cancer (PCa). Radiomics have not been explored depth in the context of predicting biochemical recurrence (BCR) of PCa. PURPOSE: To identify a set of radiomic features derived from pretreatment biparametric MRI (bpMRI) that may be predictive of PCa BCR. STUDY TYPE: Retrospective. SUBJECTS: In all, 120 PCa patients from two institutions, I1 and I2 , partitioned into training set D1 (N = 70) from I1 and independent validation set D2 (N = 50) from I2 ...
May 7, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29732280/expanded-criteria-for-active-surveillance-in-prostate-cancer-a-review-of-the-current-data
#15
REVIEW
Cameron Jones, Mina M Fam, Benjamin J Davies
Over the last ten years, active surveillance (AS) has become increasingly utilized for patients with low-risk prostate cancer. Appropriately selected AS patients have a 10-year prostate cancer-specific mortality (PCSM) approaching 99%. Therefore, some institutions have expanded the inclusion criteria for AS to avoid the unnecessary morbidity associated with overtreatment. In this review, data from several high-quality studies were compiled to demonstrate how AS inclusion criteria may be safely expanded. Although AS criteria, data reporting, and statistical methods were heterogeneous across studies, several findings were consistent and provided insight for clinical practice...
April 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29730198/long-term-outcomes-after-deferred-radical-prostatectomy-in-men-initially-managed-by-active-surveillance
#16
Rebecka Arnsrud Godtman, Max Schafferer, Carl-Gustaf Pihl, Johan Stranne, Jonas Hugosson
PURPOSE: To determine the long-term outcomes after deferred radical prostatectomy. MATERIAL AND METHODS: The study population consisted of all men with screening-detected prostate cancer who underwent deferred radical prostatectomy (n=132; 1 Jan 1995-31 Dec 2014) after active surveillance in the Göteborg Randomized, Population-based Prostate Cancer Screening Trial. The last date of follow-up was 15 May 2017. Follow-up during active surveillance was performed with prostate-specific antigen (PSA)-tests every 3-6 months and repeat biopsies every 2-4 years...
May 3, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29729858/evaluation-of-a-widely-available-patient-decision-aid-for-the-treatment-of-prostate-cancer
#17
D Feldman-Stewart, C Tong, M D Brundage
BACKGROUND: The effectiveness of patient decision aids (PtDA) is rarely evaluated in the "real world" where patients vary in their preferences related to decision support. PURPOSE: To determine how Canadian patients use and evaluate our widely available PtDA for early-stage prostate cancer treatment with its 8 components. METHODS: Google Analytics and online tracking provided usage information. A Usability Assessment (UA) following the PtDA provided evaluation data; main outcomes [scale: 1 (strongly disagree) to 5 (strongly agree)] were (a) the aid was helpful, and (b) I would recommend it to other patients...
April 24, 2018: Patient Education and Counseling
https://www.readbyqxmd.com/read/29728516/the-effect-of-including-bone-in-dixon-based-attenuation-correction-for-18-f-fluciclovine-pet-mri-of-prostate-cancer
#18
Mattijs Elschot, Kirsten M Selnæs, Håkon Johansen, Brage Krüger-Stokke, Helena Bertilsson, Tone F Bathen
The objective of this study was to evaluate the effect of including bone in DIXON-based attenuation correction for 18 F-fluciclovine Positron Emission Tomography (PET) / Magnetic Resonance Imaging (MRI) of primary and recurrent prostate cancer. Methods: 18 F-fluciclovine PET data from two PET/MRI studies - one for staging of high-risk prostate cancer (28 patients) and one for diagnosis of recurrent prostate cancer (81 patients) - were reconstructed with a 4-compartment (reference) and 5-compartment attenuation map...
May 4, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29726071/a-prospective-randomised-multi-centre-study-of-the-impact-of-ga-68-psma-pet-ct-imaging-for-staging-high-risk-prostate-cancer-prior-to-curative-intent-surgery-or-radiotherapy-propsma-study-clinical-trial-protocol
#19
Michael S Hofman, Declan G Murphy, Scott G Williams, Tatenda Nzenza, Alan Herschtal, Richard De Abreu Lourenco, Dale L Bailey, Ray Budd, Rodney J Hicks, Roslyn J Francis, Nathan Lawrentschuk
INTRODUCTION: Accurate staging of patients with prostate cancer is important for therapeutic decision making. Relapse following surgery or radiotherapy of curative intent is not uncommon and, in part, represents a failure of staging with current diagnostic imaging techniques to detect disease spread. Prostate-specific-membrane-antigen (PSMA) positron emission tomography / computed tomography (PET/CT) is a new whole body scanning technique that enables visualisation of prostate cancer with high contrast...
May 3, 2018: BJU International
https://www.readbyqxmd.com/read/29725743/3t-multiparametric-mr-imaging-piradsv2-based-detection-of-index-prostate-cancer-lesions-in-the-transition-zone-and-the-peripheral-zone-using-whole-mount-histopathology-as-reference-standard
#20
Nazanin Hajarol Asvadi, Sohrab Afshari Mirak, Amirhossein Mohammadian Bajgiran, Pooria Khoshnoodi, Pornphan Wibulpolprasert, Daniel Margolis, Anthony Sisk, Robert E Reiter, Steven S Raman
PURPOSE: To evaluate 3T mpMRI characteristics of transition zone and peripheral zone index prostate cancer lesions stratified by Gleason Score and PI-RADSv2 with whole mount histopathology correlation. METHODS: An institution review board-approved, HIPAA-compliant single-arm observational study of 425 consecutive men with 3T mpMRI prior to radical prostatectomy from December 2009 to October 2016 was performed. A genitourinary radiologist and a genitourinary pathologist matched all lesions detected on whole mount histopathology with lesions concordant for size and location on 3T mpMRI...
May 3, 2018: Abdominal Radiology
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