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https://www.readbyqxmd.com/read/27913481/anti-xa-monitoring-of-low-molecular-weight-heparin-in-adult-patients-with-cancer
#1
Lisa Baumann Kreuziger, Michael Streiff
A 68-year-old man developed a right femoral vein deep vein thrombosis and bilateral pulmonary embolism while receiving chemotherapy for stage IV prostate cancer. His creatinine at diagnosis is 1.4 mg/dL, with an estimated clearance of 63 mL/min. In patients with cancer, should low-molecular-weight heparin treatment be dosed according to weight, or adjusted using anti-Xa levels?
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27908968/psa-stratified-performance-of-18f-and-68ga-labeled-tracers-in-psma-pet-imaging-of-patients-with-biochemical-recurrence-of-prostate-cancer
#2
Felix Dietlein, Carsten Kobe, Stephan Neubauer, Matthias Schmidt, Simone Stockter, Thomas Fischer, Klaus Schomäcker, Axel Heidenreich, Boris D Zlatopolskiy, Bernd Neumaier, Alexander Drzezga, Markus Dietlein
PURPOSE: Several studies outlined the sensitivity of (68)Ga-labeled PET tracers against the prostate-specific membrane antigen (PSMA) for localization of relapsed prostate cancer in patients with renewed increase in the prostate-specific antigen (PSA), commonly referred to as biochemical recurrence. Labeling of PSMA tracers with (18)F offers numerous advantages, including improved image resolution, longer half-life and increased production yields. The aim of this study was to assess the PSA-stratified performance of the (18)F-labeled PSMA tracer (18)F-DCFPyL and the (68)Ga-labeled reference (68)Ga-PSMA-HBED-CC...
December 1, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27898584/prostate-cancer-characteristics-in-the-world-trade-center-cohort-2002-2013
#3
Dana Hashim, Paolo Boffetta, Matthew Galsky, William Oh, Roberto Lucchini, Michael Crane, Benjamin Luft, Jaqueline Moline, Iris Udasin, Denise Harrison, Emanuela Taioli
An increased incidence of prostate cancer was reported in three cohorts of World Trade Center (WTC) respondents. It is uncertain whether this increase is because of WTC-related exposures or enhanced surveillance. Prostate cancer cases (2002-2013) were obtained from the WTC Health Program. Age, race, and Gleason score distribution were compared with New York State Cancer Registry cases from the same time period. Multivariate models were adjusted for age and race. Analyses of clinical characteristics of prostate cancer cases within the cohort were also carried out, adjusting for age, race, and WTC exposure categories...
November 24, 2016: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/27895677/predictors-of-prostate-volume-reduction-following-neoadjuvant-cytoreductive-androgen-suppression
#4
Krishan R Jethwa, Keith M Furutani, Lance A Mynderse, Torrence M Wilson, Richard Choo, Bernard F King, Eric Bergstralh, Brian J Davis
PURPOSE: Limited duration cytoreductive neoadjuvant hormonal therapy (NHT) is used prior to definitive radiotherapeutic management of prostate cancer to decrease prostate volume. The purpose of this study is to examine the effect of NHT on prostate volume before permanent prostate brachytherapy (PPB), and determine associated predictive factors. MATERIAL AND METHODS: Between June 1998 and April 2012, a total of 1,110 patients underwent PPB and 207 patients underwent NHT...
October 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/27882806/comorbidity-as-a-predictor-of-overall-survival-in-prostate-cancer-patients-treated-with-external-beam-radiotherapy-combined-with-hdr-brachytherapy-boosts
#5
Marie Hjälm-Eriksson, Anders Ullén, Hemming Johansson, Seymoure Levitt, Sten Nilsson, Karl-Mikael Kälkner
BACKGROUND: The risk stratification currently applied prior to curative treatment for localized prostate cancer (PC) does not take into account comorbidity or age. Therefore, we investigated the impact of comorbidity on overall survival (OS) in PC patients treated with external beam radiotherapy (EBRT) and high-dose rate (HDR) brachytherapy boost. MATERIAL AND METHODS: At a single center, 611 consecutive patients diagnosed with localized PC from 1998 to 2004 underwent definitive EBRT (50 Gy) and HDR brachytherapy boosts (2 × 10 Gy) combined with neoadjuvant total androgen blockade...
November 24, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27876305/new-prostate-cancer-grading-system-predicts-long-term-survival-following-surgery-for-gleason-score-8-10-prostate-cancer
#6
Won Sik Ham, Heather J Chalfin, Zhaoyong Feng, Bruce J Trock, Jonathan I Epstein, Carling Cheung, Elizabeth Humphreys, Alan W Partin, Misop Han
BACKGROUND: The newly proposed five-tiered prostate cancer grading system (PCGS) divides Gleason score (GS) 8-10 disease into GS 8 and GS 9-10 on the basis of biochemical recurrence (BCR) following radical prostatectomy (RP) as an outcome. However, BCR does not necessarily portend worse survival outcomes. OBJECTIVE: To assess the significance of distinguishing GS 8 versus 9-10 disease in terms of long-term survival outcomes for both the preoperative setting using biopsy (Bx) GS and the postoperative setting with RP GS...
November 19, 2016: European Urology
https://www.readbyqxmd.com/read/27868214/low-intratumoral-mast-cells-are-associated-with-a-higher-risk-of-prostate-cancer-recurrence
#7
Heidi A Hempel, Nathan S Cuka, Ibrahim Kulac, John R Barber, Toby C Cornish, Elizabeth A Platz, Angelo M De Marzo, Karen S Sfanos
BACKGROUND: Mast cells are of interest in prostate cancer because they possess both pro- and anti-tumorigenic properties and are present in the tumor microenvironment. We studied the association of mast cell count and densities with prostate cancer recurrence using tissue microarrays (TMAs) for 462 men who recurred (cases) and 462 controls that were matched to the cases nested in a cohort of radical prostatectomy patients. METHODS: Dual-immunostaining for mast cell tryptase and epithelial cytokeratin-8 and whole slide image analysis were used to assess total mast cell number, mast cell density (mast cell number/tissue area), and mast cell number per epithelial or stromal area in TMA spots containing tumor (up to 4 per man)...
November 21, 2016: Prostate
https://www.readbyqxmd.com/read/27849668/risk-of-acute-testicular-failure-after-preoperative-radiotherapy-for-rectal-cancer-a-prospective-cohort-study
#8
Christian Buchli, Anna Martling, Massoud Al Abani, Jan-Erik Frödin, Matteo Bottai, Ingmar Lax, Stefan Arver, Torbjörn Holm
OBJECTIVE: The aim of this study was to assess the acute effect of preoperative RT for rectal cancer on endocrine testicular function. BACKGROUND: Preoperative radiotherapy (RT) enhances local control and cancer-specific survival in patients treated for rectal cancer. In case series, a negative acute effect on Leydig cell function has been reported. METHODS: This prospective cohort study included 168 males with rectal or prostate cancer stage I-III...
November 15, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27842896/kinesin-family-member-11-mrna-expression-predicts-prostate-cancer-aggressiveness
#9
Xuan-Mei Piao, Young Joon Byun, Pildu Jeong, Yun-Sok Ha, Eun Sang Yoo, Seok Joong Yun, Wun-Jae Kim
BACKGROUND: KIF11 (kinesin family member 11), a molecular motor protein, is essential to mitosis and cell cycle progression. Inhibitors of KIF11 have been developed as chemotherapeutic agents for the treatment of various cancers. Regarding prostate cancer (PCa), clinical trials using KIF11 inhibitors for the treatment of castration-resistant PCa have been initiated. We hypothesized that a relationship might exist between KIF11 expression and PCa. To investigate the functional activities and clinical usefulness of KIF11 in PCa, we used quantitative real-time reverse transcriptase polymerase chain reaction to monitor the KIF11 expression patterns...
October 19, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27842672/can-multiparametric-mri-replace-roach-equations-in-staging-prostate-cancer-before-external-beam-radiation-therapy
#10
Rossano Girometti, Marco Andrea Signor, Martina Pancot, Lorenzo Cereser, Chiara Zuiani
PURPOSE: To investigate the agreement between Roach equations (RE) and multiparametric magnetic resonance imaging (mpMRI) in assessing the T-stage of prostate cancer (PCa). MATERIALS AND METHODS: Seventy-three patients with biopsy-proven PCa and previous RE assessment prospectively underwent mpMRI on a 3.0T magnet before external beam radiation therapy (EBRT). Using Cohen's kappa statistic, we assessed the agreement between RE and mpMRI in defining the T-stage (≥T3 vs...
December 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27837416/a-simple-prognostic-model-involving-prostate-specific-antigen-alkaline-phosphatase-and-albumin-for-predicting-the-time-required-to-progress-to-castration-resistant-prostate-cancer-in-patients-who-received-androgen-deprivation-therapy
#11
Wei Lv, Hongxiang Shang, Xinqi Pei, Yule Chen, Hongjun Xie, Dalin He, Xinyang Wang, Lei Li
PURPOSE: To distinguish potential biomarkers and build a useful model to predict the time required to progress to castration-resistant prostate cancer (CRPC) in patients with prostate cancer who have been treated with androgen deprivation therapy (ADT). METHODS: We considered 168 patients who received ADT as the initial therapy. Complete clinical data including age, tumor stage, Gleason score, prostate-specific antigen (PSA), complete blood count and liver function tests were analyzed...
November 11, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27836000/unusual-side-effect-from-a-luteinizing-hormone-releasing-hormone-agonist-leuprorelin-in-the-treatment-of-prostate-cancer-a-case-report
#12
John I-Chiang Chang, Joseph Bucci
BACKGROUND: The treatment options for high-risk prostate cancer are either radical prostatectomy or radiotherapy/brachytherapy depending on the patients' prognosis. In older men with multiple comorbidities, radiotherapy with androgen deprivation therapy is an attractive option. Common side effects of androgen deprivation therapy include hot flushes, tiredness, increased risk of fractures, increased risk of metabolic disorders, coronary heart disease, and psychological effects. This case highlights the potential side effect of lipodystrophy secondary to leuprolide acetate injections...
November 11, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27802002/robot-assisted-laparoscopic-radical-prostatectomy-with-early-retrograde-release-of-the-neurovascular-bundle-and-endopelvic-fascia-sparing
#13
George Augusto Monteiro Lins de Albuquerque, Giuliano Betoni Guglielmetti, Maurício Dener Cordeiro, William Carlos Nahas, Rafael Ferreira Coelho
INTRODUCTION: Robotic-assisted radical prostatectomy (RAP) is the dominant minimally invasive surgical treatment for patients with localized prostate cancer. The introduction of robotic assistance has the potential to improve surgical outcomes and reduce the steep learning curve associated with conventional laparoscopic radical prostatectomy. The purpose of this video is to demonstrate the early retrograde release of the neurovascular bundle without open the endopelvic fascia during RAP...
November 2, 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27801727/the-immunohistochemical-analysis-of-socs3-protein-identifies-a-subgroup-of-prostatic-cancer-biopsies-with-aggressive-behavior
#14
Francesco Pierconti, Maurizio Martini, Tonia Cenci, Luigi M Larocca
BACKGROUND: Recently, we demonstrated that hypermethylation of SOCS3 determines a significant reduction of its mRNA and protein expression and identifies a subgroup of prostate cancer with aggressive behavior. In this paper, our objective was to investigate whether the immunohistochemical expression of the SOCS3 protein could represent an alternative method to molecular analysis for the individualization of aggressive prostate carcinoma. MATERIALS AND METHODS: We analyzed the SOCS3 immunohistochemical expression in 65 patients undergoing biopsies at the Institute of Urology of our hospital between September 2011 and October 2011 (median age, 66...
October 31, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/27793023/low-serum-total-testosterone-level-as-a-predictor-of-upstaging-and-upgrading-in-low-risk-prostate-cancer-patients-meeting-the-inclusion-criteria-for-active-surveillance
#15
Matteo Ferro, Giuseppe Lucarelli, Dario Bruzzese, Giuseppe Di Lorenzo, Sisto Perdonà, Riccardo Autorino, Francesco Cantiello, Roberto La Rocca, Gian Maria Busetto, Amelia Cimmino, Carlo Buonerba, Michele Battaglia, Rocco Damiano, Ottavio De Cobelli, Vincenzo Mirone, Daniela Terracciano
Active surveillance (AS) is currently a widely accepted treatment option for men with clinically localized prostate cancer (PCa). Several reports have highlighted the association of low serum testosterone levels with high-grade, high-stage PCa. However, the impact of serum testosterone as a predictor of progression in men with low-risk PCa has been little assessed.In this study, we evaluated the association of circulating testosterone concentrations with a staging/grading reclassification in a cohort of low-risk PCa patients meeting the inclusion criteria for the AS protocol but opting for radical prostatectomy...
October 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27785560/multiparametric-magnetic-resonance-imaging-for-prostate-cancer-a-comparative-study-including-radical-prostatectomy-specimens
#16
Liam Toner, Nathan Papa, Marlon Perera, Nikolas Katelaris, Mahesha Weerakoon, Kwang Chin, Laurence Harewood, Damien M Bolton, Nathan Lawrentschuk
PURPOSE: To evaluate the diagnostic and staging ability of multiparametric MRI (mpMRI) compared to radical prostatectomy (RP) specimens after dissemination of this technology to several centres. mpMRI is an evolving technique aiming to improve upon the diagnostic sensitivity of prostate biopsy for the diagnosis of prostate cancer. Differences in interpretation, expertise and application of mpMRI are responsible for the range of reported results. METHODS: This retrospective clinical study was conducted with consecutive patients through an electronic database of tertiary hospitals and adjacent private urology practices in Australia...
October 26, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27783436/role-of-pi-radsv2-with-multiparametric-mri-in-determining-who-needs-active-surveillance-or-definitive-treatment-according-to-prias
#17
Jung Jae Park, Byung Kwan Park
PURPOSE: To evaluate the role of Prostate Imaging Reporting and Data System v. 2 (PI-RADSv2) in triaging patients with prostate cancer according to Prostate Cancer Research International: Active Surveillance (PRIAS). MATERIALS AND METHODS: Between January 2012 and December 2014, 456 patients with biopsy-proven cancer underwent multiparametric 3T magnetic resonance imaging (MRI) using T2 -weighted, diffusion-weighted, and dynamic contrast-enhanced MRI sequences, and then radical prostatectomy...
October 26, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27778117/a-comparison-of-clinical-outcomes-between-three-dimensional-conformal-radiotherapy-and-intensity-modulated-radiotherapy-for-prostate-cancer
#18
Takuya Shimizuguchi, Keiji Nihei, Tomoyuki Okano, Yumiko Machitori, Kei Ito, Katsuyuki Karasawa
BACKGROUND: Intensity-modulated radiation therapy (IMRT) reduces the dose delivered to organs at risk. However, there have been few direct comparisons of IMRT with conventional three-dimensional conformal radiotherapy (3DCRT). The aim of this study was to evaluate the clinical benefit of IMRT in terms of toxicity and biochemical control. METHODS: The medical records of 203 consecutive patients with localized to non-metastatic (stage T1a-T3bN0M0) prostate cancer between 2007 and 2011 were retrospectively reviewed...
October 24, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27773340/influence-of-the-location-and-number-of-metastases-in-the-survival-of-metastatic-prostatic-cancer-patients
#19
A Guijarro, V Hernández, J M de la Morena, I Jiménez-Valladolid, E Pérez-Fernández, E de la Peña, C Llorente
INTRODUCTION: The prognosis of patients diagnosed with metastatic prostate cancer seems to be modulated by factors such as the number and site of metastases. Our objective is to evaluate survival outcomes according to the number and site of metastases in our series of metastatic patients over the last 15 years. MATERIALS AND METHODS: A retrospective analysis was performed on patients diagnosed between 1998 and 2014. We analyzed overall survival and progression-free survival, depending on the number and location of metastases on patients with newly diagnosed metastatic prostate cancer...
October 20, 2016: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/27768168/uptake-of-active-surveillance-for-very-low-risk-prostate-cancer-in-sweden
#20
Stacy Loeb, Yasin Folkvaljon, Caitlin Curnyn, David Robinson, Ola Bratt, Pär Stattin
Importance: Active surveillance is an important option to reduce prostate cancer overtreatment, but it remains underutilized in many countries. Models from the United States show that greater use of active surveillance is important for prostate cancer screening to be cost-effective. Objectives: To perform an up-to-date, nationwide, population-based study on use of active surveillance for localized prostate cancer in Sweden. Design, Setting, and Participants: Cross-sectional study in the National Prostate Cancer Register (NPCR) of Sweden from 2009 through 2014...
October 20, 2016: JAMA Oncology
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