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Stage 4 prostate cancer

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https://www.readbyqxmd.com/read/29332451/psca-rs1045531-polymorphism-and-the-risk-of-prostate-cancer-in-a-chinese-population-undergoing-prostate-biopsy
#1
Xuefeng Zhang, Qin Hu, Ye Chen, Miao Li, Huming Yin, Chenchao Zhou, Gang Li, Jianquan Hou
BACKGROUND AND PURPOSE: This study explored the association between a single-nucleotide polymorphism of prostate stem cell antigen and prostate cancer in Chinese patients undergoing prostate biopsy. MATERIALS AND METHODS: DNA from 416 patients undergoing prostate biopsy was typed for the prostate stem cell antigen rs1045531 single-nucleotide polymorphism. The frequency of the rs1045531 polymorphism in patients with prostate cancer and in patients with benign prostatic hyperplasia was compared...
December 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29326358/targeted-alpha-therapy-of-mcrpc-with-225actinium-psma-617-swimmer-plot-analysis-suggests-efficacy-regarding-duration-of-tumor-control
#2
Clemens Kratochwil, Frank Bruchertseifer, Hendrik Rathke, Markus Hohenfellner, Frederik L Giesel, Uwe Haberkorn, Alfred Morgenstern
The aim of this evaluation is to identify first indicators regarding the efficacy of 225Ac-PSMA-617 therapy in a retrospectively analyzed group of patients. Methods: Forty patients with metastatic castration-resistant prostate cancer were selected for treatment with 3 cycles of 100 kBq/kgBW 225Ac-PSMA-617 in 2 months intervals. Prostate-specific antigen (PSA) and blood cell count were measured every 4 weeks. Prostate-specific membrane antigen (PSMA)-PET/CT or PSMA-SPECT/CT were used for baseline staging and imaging follow-up at month six...
January 11, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29324926/risk-stratification-and-staging-in-prostate-cancer-with-prostatic-specific-membrane-antigen-pet-ctobjective-a-one-stop-shop
#3
Manoj Gupta, Partha Sarathi Choudhury, Sudhir Rawal, Harish Chandra Goel, Amitabh Singh, Vineet Talwar, Saroj Kumar Sahoo
OBJECTIVE: Current imaging modalities for prostate cancer (PC) had limitations for risk stratification and staging. Magnetic resonance imaging (MRI) frequently underestimated lymphatic metastasis while bone scintigraphy often had diagnostic dilemmas. Prostatic specific membrane antigen (PSMA) positron emission tomography-computed tomography (PET/CT) has been remarkable in diagnosing PC recurrence and staging. We hypothesized it can become one-stop-shop for initial risk stratification and staging...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29323548/18f-fluorocholine-pet-whole-body-mri-in-the-staging-of-high-risk-prostate-cancer
#4
Ur Metser, Alejandro Berlin, Jaydeep Halankar, Grainne Murphy, Kartik S Jhaveri, Sangeet Ghai, Noam Tau
OBJECTIVE: The purpose of this study was to determine whether integrated 18F-fluorocholine (FCH) PET whole-body MRI (PET/WBMRI) depicts lymph node and distant metastases in patients with high-risk prostate cancer more frequently than does conventional staging. SUBJECTS AND METHODS: A prospective study included 58 patients with untreated high-risk prostate cancer. After conventional staging (CT and bone scintigraphy), patients underwent FCH PET/WBMRI (n = 10) or FCH PET/CT and WBMRI (n = 48)...
January 11, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29321194/polygenic-hazard-score-to-guide-screening-for-aggressive-prostate-cancer-development-and-validation-in-large-scale-cohorts
#5
Tyler M Seibert, Chun Chieh Fan, Yunpeng Wang, Verena Zuber, Roshan Karunamuni, J Kellogg Parsons, Rosalind A Eeles, Douglas F Easton, ZSofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch Garcia, Kenneth Muir, Henrik Grönberg, Fredrik Wiklund, Markus Aly, Johanna Schleutker, Csilla Sipeky, Teuvo Lj Tammela, Børge G Nordestgaard, Sune F Nielsen, Maren Weischer, Rasmus Bisbjerg, M Andreas Røder, Peter Iversen, Tim J Key, Ruth C Travis, David E Neal, Jenny L Donovan, Freddie C Hamdy, Paul Pharoah, Nora Pashayan, Kay-Tee Khaw, Christiane Maier, Walther Vogel, Manuel Luedeke, Kathleen Herkommer, Adam S Kibel, Cezary Cybulski, Dominika Wokolorczyk, Wojciech Kluzniak, Lisa Cannon-Albright, Hermann Brenner, Katarina Cuk, Kai-Uwe Saum, Jong Y Park, Thomas A Sellers, Chavdar Slavov, Radka Kaneva, Vanio Mitev, Jyotsna Batra, Judith A Clements, Amanda Spurdle, Manuel R Teixeira, Paula Paulo, Sofia Maia, Hardev Pandha, Agnieszka Michael, Andrzej Kierzek, David S Karow, Ian G Mills, Ole A Andreassen, Anders M Dale
OBJECTIVES: To develop and validate a genetic tool to predict age of onset of aggressive prostate cancer (PCa) and to guide decisions of who to screen and at what age. DESIGN: Analysis of genotype, PCa status, and age to select single nucleotide polymorphisms (SNPs) associated with diagnosis. These polymorphisms were incorporated into a survival analysis to estimate their effects on age at diagnosis of aggressive PCa (that is, not eligible for surveillance according to National Comprehensive Cancer Network guidelines; any of Gleason score ≥7, stage T3-T4, PSA (prostate specific antigen) concentration ≥10 ng/L, nodal metastasis, distant metastasis)...
January 10, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29306731/the-impact-of-lymph-node-metastases-burden-at-radical-prostatectomy
#6
Felix Preisser, Michele Marchioni, Sebastiano Nazzani, Marco Bandini, Zhe Tian, Raisa S Pompe, Francesco Montorsi, Fred Saad, Firas Abdollah, Thomas Steuber, Hans Heinzer, Hartwig Huland, Markus Graefen, Derya Tilki, Pierre I Karakiewicz
BACKGROUND: We hypothesized that a cut-off in positive lymph node (LN) counts may discriminate between cancer-specific mortality (CSM) rates in clinically localized prostate cancer patients treated with radical prostatectomy (RP). OBJECTIVE: To test this relationship, we relied on different LN count cut-offs, as well as the continuously coded number of positive LNs (NPN). METHODS: Within the Surveillance, Epidemiology, and End Results database (2004-2014), we identified patients with D'Amico intermediate- or high-risk characteristics who underwent RP and pelvic LN dissection, regardless of pathologic LN stage...
January 3, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29306325/incidence-of-bone-metastases-in-patients-with-solid-tumors-analysis-of-oncology-electronic-medical-records-in-the-united-states
#7
Rohini K Hernandez, Sally W Wade, Adam Reich, Melissa Pirolli, Alexander Liede, Gary H Lyman
BACKGROUND: Bone metastases commonly occur in conjunction with solid tumors, and are associated with serious bone complications. Population-based estimates of bone metastasis incidence are limited, often based on autopsy data, and may not reflect current treatment patterns. METHODS: Electronic medical records (OSCER, Oncology Services Comprehensive Electronic Records, 569,000 patients, 52 US cancer centers) were used to identify patients ≥18 years with a solid tumor diagnosis recorded between 1/1/2004 and 12/31/2013, excluding patients with hematologic tumors or multiple primaries...
January 6, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29288121/contemporary-incidence-outcomes-of-prostate-cancer-lymph-node-metastases
#8
Adrien N Bernstein, Jonathan E Shoag, Ron Golan, Joshua A Halpern, Edward M Schaeffer, Wei-Chun Hsu, Paul L Nguyen, Art Sedrakyan, Ronald C Chen, Scott E Eggener, Jim C Hu
PURPOSE: The incidence of localized prostate cancer has declined with shifts in prostate cancer screening. While recent population-based studies demonstrate a stable incidence of loco-regional prostate cancer, this categorized organ-confined, extra-prostatic and lymph node positive disease together. The contemporary incidence of prostate cancer with pelvic lymph node metastases (PLNM) however, remains unknown. METHODS: We used Surveillance, Epidemiology and End Results (SEER) from 2004 to 2014 to identify men diagnosed with prostate cancer...
December 26, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29279147/seminal-vesicle-invasion-on-multi-parametric-magnetic-resonance-imaging-correlation-with-histopathology
#9
Nikolaos Grivas, Karel Hinnen, Jeroen de Jong, Wilma Heemsbergen, Luc Moonen, Thelma Witteveen, Henk van der Poel, Stijn Heijmink
OBJECTIVES: The pre-treatment risk of seminal vesicle (SV) invasion (SVI) from prostate cancer is currently based on nomograms which include clinical stage (cT), Gleason score (GS) and prostate-specific antigen (PSA). The aim of our study was to evaluate the staging accuracy of 3T (3T) multi-parametric (mp) Magnetic Resonance Imaging (MRI) by comparing the imaging report of SVI with the tissue histopathology. The additional value in the existing prediction models and the role of radiologists' experience were also examined...
January 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29261618/metastasized-18f-dcfpyl-negative-prostatic-adenocarcinoma-without-neuroendocrine-differentiation
#10
Wouter A M Broos, Marielle Kocken, Friso M van der Zant, Remco J J Knol, Maurits Wondergem
A 76-year-old man with histopathologically proven prostate cancer (initial prostate-specific antigen 110 ng/mL, Gleason 3 + 4 = 7) received F-DCFPyL PET/CT for initial staging. Both the primary tumor and pathologically enlarged pelvic lymph nodes showed no increased F-DCFPyL uptake. Subsequent histopathologic lymph node biopsy revealed prostate cancer metastasis. Prostate-specific membrane antigen tracers, such as F-DCFPyL, are promising radiopharmaceuticals for prostate cancer imaging. False-negative prostate-specific membrane antigen PET/CT findings have been reported earlier for prostate tumors with neuroendocrine differentiation...
December 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29247473/the-movember-foundation-s-gap3-cohort-a-profile-of-the-largest-global-prostate-cancer-active-surveillance-database-to-date
#11
S M Bruinsma, L Zhang, M J Roobol, C H Bangma, E W Steyerberg, D Nieboer, M Van Hemelrijck
OBJECTIVES: The Movember Foundation launched the Global Action Plan Prostate Cancer Active Surveillance (GAP3) initiative to create a global consensus on the selection and monitoring of men with low-risk prostate cancer (PCa) on active surveillance (AS). The aim of this study is to present data on inclusion and follow-up for AS in this unique global AS database. SUBJECTS/PATIENTS (OR MATERIALS) AND METHODS: Between 2014 and 2016, the database was created by combining patient data from 25 established AS cohorts worldwide (USA, Canada, Australasia, UK, Europe) (n=15,101)...
December 15, 2017: BJU International
https://www.readbyqxmd.com/read/29239082/utility-of-early-transperineal-template-guided-prostate-biopsy-for-risk-stratification-in-men-undergoing-active-surveillance-for-prostate-cancer
#12
James Voss, Raj Pal, Shaista Ahmed, Magnus Hannah, Adil Jaulim, Thomas Walton
OBJECTIVE: To assess the accuracy and utility of routine multiparametric MRI (mp-MRI) and transperineal template-guided prostate biopsy (TPB) following enrolment on to active surveillance. PATIENTS AND METHODS: From April 2012 to December 2016 consecutive men from our single institution diagnosed with low or intermediate risk prostate cancer on TRUS biopsy were offered further staging with early mp-MRI and TPB within 12 months of diagnosis. Data was collected prospectively...
December 14, 2017: BJU International
https://www.readbyqxmd.com/read/29226828/cancer-mortality-in-the-urological-department-of-the-sylvanus-olympio-teaching-hospital-in-lome-togo
#13
E V Sewa, K Tengue, M T Kpatcha, G Botcho, K H Sikpa, E Leloua, T Anoukoum, E D Dosseh
To determine the proportion of cancer mortality seen in the urology department of a teaching hospital in sub-Saharan Africa and to identify the contributing factors. This 10-year retrospective study took place in the urology department of the Sylvanus Olympio Teaching Hospital of Lomé (Togo) and analyzed the records of patients who died of cancer from January 2006 through December 2015. During the study period, 94 deaths were recorded in the department, 84% of them due to a urological cancer. The mean age of patients was 62 years,- and there was a significant male predominance with a sex ratio of 4...
December 11, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/29207031/prl%C3%A2-3-increases-the-aggressive-phenotype-of-prostate-cancer-cells-in%C3%A2-vitro-and-its-expression-correlates-with-high-grade-prostate-tumors-in-patients
#14
Donna R Edwards, Krzysztof Moroz, Haitao Zhang, David Mulholland, Asim B Abdel-Mageed, Debasis Mondal
The increased expression of phosphatase of regenerating liver-3 (PRL‑3) has been shown to be associated with the aggressive and metastatic phenotype of different solid tumors. However, it is not known whether PRL‑3 plays a similar role in the progression of prostate cancer (PCa). In this study, immunoblot analysis of androgen receptor (AR)-positive PCa lines (LNCaP and LNCaP‑SF) revealed the constitutive cytoplasmic expression of PRL‑3, and stimulation with R1881 (AR agonist) rapidly increased the nuclear translocation of PRL‑3...
November 20, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29205339/acne-in-late-adolescence-and-risk-of-prostate-cancer
#15
Henrik Ugge, Ruzan Udumyan, Jessica Carlsson, Ove Andrén, Scott Montgomery, Sabina Davidsson, Katja Fall
Accumulating evidence suggest that Propionibacterium acnes may play a role in prostate carcinogenesis, but data are so far limited and inconclusive. The aim of this population-based cohort study was therefore to test whether presence of acne vulgaris during late adolescence is associated with an increased risk of prostate cancer later in life. We identified a large cohort of young men born in Sweden between 1952 and 1956, who underwent mandatory assessment for military conscription around the age of 18 (n = 243,187)...
December 4, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29199015/contemporary-prognostic-indicators-for-prostate-cancer-incorporating-international-society-of-urological-pathology-recommendations
#16
REVIEW
Lars Egevad, Brett Delahunt, Glen Kristiansen, Hemamali Samaratunga, Murali Varma
Prognostic assessment is a key element in the management of patients with prostate cancer as it informs both treatment, follow-up and outcome prediction. Tumour grade should be based upon the novel and evidence-based recommendations of the International Society of Urological Pathology (ISUP) Consensus Conference of 2014, with ISUP grades 1-5 being derived from 2005 ISUP modified Gleason grading, i.e., ISUP grade 1 (3 + 3 = 6), grade 2 (3 + 4 = 7), grade 3 (4 + 3 = 7), grade 4 (3 + 5 = 8, 5 + 3 = 8, 4 + 4 = 8), and grade 5 (4 + 5 = 9 5 + 4 = 9, 5 + 5 = 10)...
November 30, 2017: Pathology
https://www.readbyqxmd.com/read/29198168/simultaneous-laparoscopic-proctocolectomy-tatme-and-robot-assisted-radical-prostatectomy-for-synchronous-rectal-and-prostate-cancer
#17
Ben Gys, Karen Fransis, Guy Hubens, Sylvie Van den Broeck, Bart Op de Beeck, Niels Komen
OBJECTIVE: We would like to present a patient with a history of ulcerative colitis suffering from a synchronous rectal and prostate cancer treated with a laparoscopic total proctocolectomy (with TaTME) and Retzius sparing RARP simultaneously. METHODS: Retzius sparing RARP with bilateral lymph node harvesting was performed first. Afterwards, TaTME was commenced with the placement of a Lonestar® retractor and GelPort®. Anterior dissection was troubled unexpectedly by outspoken fibrosis...
December 4, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/29196529/no-association-of-waist-circumference-and-prostate-cancer-in-the-cancer-prevention-study-ii-nutrition-cohort
#18
Victoria L Stevens, Eric J Jacobs, Maret L Maliniak, Alpa V Patel, Susan M Gapstur
Background: The relationship between excess body weight and prostate cancer risk is unclear. However, some evidence suggests that waist circumference, which provides a measure of central adiposity, may be positively associated with more advanced stages or grades of prostate cancer.Methods: The association between waist circumference and prostate cancer was investigated among 46,094 men enrolled in the Cancer Prevention Study II Nutrition Cohort, of whom 5,711 were diagnosed with this cancer between 1997 and 2013...
December 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29196209/pathologic-outcomes-of-gleason-6-favorable-intermediate-risk-prostate-cancer-treated-with-radical-prostatectomy-implications-for-active-surveillance
#19
David D Yang, Brandon A Mahal, Vinayak Muralidhar, Marie E Vastola, Ninjin Boldbaatar, Shelby A Labe, Michelle D Nezolosky, Peter F Orio, Martin T King, Neil E Martin, Kent W Mouw, Quoc-Dien Trinh, Paul L Nguyen
BACKGROUND: The safety of active surveillance (AS) for Gleason 6 favorable intermediate-risk (FIR) prostate cancer is unknown. To provide guidance, we examined the incidence and predictors of upgrading or upstaging for Gleason 6 FIR patients treated with radical prostatectomy. PATIENTS AND METHODS: We identified 2807 men in the National Cancer Database diagnosed from 2010 to 2012 with Gleason 6 FIR disease (<50% positive biopsy cores [PBC] with either prostate-specific antigen [PSA] of 10-20 ng/mL or cT2b-T2c disease) treated with radical prostatectomy...
November 9, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29187884/a-single-nucleotide-polymorphism-in-hpgd-gene-is-associated-with-prostate-cancer-risk
#20
Xiaofei Qi, Yu Wang, Jianquan Hou, Yuhua Huang
Introduction: The HPGD gene was associated with some cancers, such as colorectal, breast, prostate, and bladder. However, detailed role of 15-hydroxyprostaglandin dehydrogenase (HPGD) gene remain unclear in prostate cancer. The study was to investigate the correlation between rs8752 that located in the 3'untranslated region (UTR) of the 15-hydroxyprostaglandin dehydrogenase (HPGD) gene and prostate cancer (PCa) risk. Materials and Methods: 109 patients from the First Affiliate Hospital of Soochow University were recruited...
2017: Journal of Cancer
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