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https://www.readbyqxmd.com/read/28209461/prostate-cancer-detection-rate-in-indonesian-men
#1
Chaidir Arif Mochtar, Widi Atmoko, Rainy Umbas, Agus Rizal Ardy Hariandy Hamid
PURPOSES OF THE STUDY: To evaluate the overall detection rate of prostate cancer in biopsies according to serum prostate-specific antigen levels, determine the number of cores biopsied in Indonesian men, and provide a correlated staging of prostate cancer patients at varying intervals of prostate-specific antigen levels. METHODS: We retrospectively analyzed the data from Indonesian men who had undergone prostate biopsy at two national referral medical centers in Jakarta from January 1995 to December 2014...
February 13, 2017: Asian Journal of Surgery
https://www.readbyqxmd.com/read/28193072/semiautomated-support-photoelectrochemical-immunosensing-platform-for-portable-and-high-throughput-immunoassay-based-on-au-nanocrystal-decorated-specific-crystal-facets-bivo4-photoanode
#2
Jian Shu, Zhenli Qiu, Zhenzhen Lin, Guoneng Cai, Huanghao Yang, Dianping Tang
Photoelectrochemical (PEC) measurement has been developed rapidly for bioanalysis in recent years. However, the actual application for most existed PEC bioanalytical systems is still a challenge because the perfect solutions for sensing surface design, high-throughput detection, and portability are lacked. To successfully overcome these limitations and realize accurate, continuous screening and assessing on prognostic indicator of early stage cancer on the spot, an innovative and portable semiautomated support power-free photoelectrochemical (SP-PEC) immunosensing platform consisted with a miniature semiautomatic injection system and digital multimeter (DMM) readout is designed (prostate specific antigen, PSA, was used as the proof-of-concept analyte)...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28177964/contemporary-gleason-grading-of-prostatic-carcinoma-an-update-with-discussion-on-practical-issues-to-implement-the-2014-international-society-of-urological-pathology-isup-consensus-conference-on-gleason-grading-of-prostatic-carcinoma
#3
Jonathan I Epstein, Mahul B Amin, Victor E Reuter, Peter A Humphrey
The primary proceedings of the 2014 International Society of Urological Pathology Grading Conference were published promptly in 2015 and dealt with: (1) definition of various grading patterns of usual acinar carcinoma, (2) grading of intraductal carcinoma; and (3) support for the previously proposed new Grade Groups. The current manuscript in addition to highlighting practical issues to implement the 2014 recommendations, provides an updated perspective based on numerous studies published after the 2014 meeting...
February 7, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28169842/challenges-in-management-of-squamous-cell-carcinoma-of-the-anus-in-new-england-and-across-the-united-states-a-review-of-the-national-cancer-data-base
#4
Victor E Pricolo, Kyle L Viani, Matteo Bonvini, Carlo F Abelli, Tracey J McDuffie
BACKGROUND: Management of squamous cell carcinoma of the anus (SCCA) is becoming more relevant, as its incidence continues to increase. The purpose of this study was to evaluate regional and national data to assess trends in epidemiology, access to cancer center care, and overall management strategies in SCCA. STUDY DESIGN: A review of available data from the American College of Surgeons Committee on Cancer National Cancer Data Base focused on incidence, sex, age, stage at diagnosis, distance traveled for care, and utilization of therapy as first course of treatment (FCT)...
February 6, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28166149/incidental-detection-of-head-and-neck-squamous-cell-carcinoma-on-68ga-psma-11-pet-ct
#5
Courtney Lawhn-Heath, Robert R Flavell, Christine Glastonbury, Thomas A Hope, Spencer C Behr
We present a case of an incidentally detected squamous cell carcinoma of the oropharynx on Ga-PSMA-11 PET. A 71-year-old man's condition was diagnosed as prostate carcinoma after a year of rising serum prostate-specific antigen. The staging Ga-PSMA PET/CT demonstrated focal radiotracer uptake in the prostate corresponding to his known primary prostate cancer. However, a PSMA-avid 3.4-cm mass was incidentally found in the right tongue base that was biopsied, confirming squamous cell carcinoma.
February 3, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28161349/obesity-as-a-risk-factor-for-unfavorable-disease-in-low-risk-prostate-cancer-and-its-relationship-with-anatomic-location-of-tumor
#6
In Gab Jeong, Sangjun Yoo, Chunwoo Lee, Myong Kim, Dalsan You, Cheryn Song, Sungchan Park, Jun Hyuk Hong, Hanjong Ahn, Choung-Soo Kim
PURPOSE: To investigate the influence of obesity on unfavorable disease in low-risk prostate cancer eligible for active surveillance and verify the underlying relationship with tumor location. MATERIALS AND METHODS: We analyzed 890 patients with biopsy Gleason score 6 who underwent radical prostatectomy for prostate cancer via multicore (≥12) biopsy at our institution. Unfavorable disease was defined as primary Gleason pattern ≥4 or pathologic stage ≥T3. Multivariate logistic regression analysis was performed to identify factors associated with unfavorable disease...
February 1, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28161322/radical-prostatectomy-neutralizes-obesity-driven-risk-of-prostate-cancer-progression
#7
Jonas Schiffmann, Georg Salomon, Derya Tilki, Lars Budäus, Pierre I Karakiewicz, Sami-Ramzi Leyh-Bannurah, Raisa S Pompe, Alexander Haese, Hans Heinzer, Hartwig Huland, Markus Graefen, Pierre Tennstedt
INTRODUCTION: Obesity negatively affects several prostate cancer (PCa) outcomes, including mortality to PCa. However, the validity of several such associations is still under debate, including its effect on pathological stage at radical prostatectomy (RP) and subsequent biochemical recurrence (BCR), which represents the focus of this study. METHODS: We relied on patients with PCa treated with RP at the Martini-Klinik Prostate Cancer Center between 2004 and 2015...
February 1, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28157066/multiparametric-mri-in-detection-and-staging-of-prostate-cancer
#8
Lars Boesen
BACKGROUND: Prostate cancer (PCa) is the second leading cause of cancer-related mortality and the most frequently diagnosed male malignant disease among men in the Nordic countries. The manifestation of PCa ranges from indolent to highly aggressive disease and due to this high variation in PCa progression, the diagnosis and subsequent treatment planning can be challenging. The current diagnostic approach with PSA testing and digital rectal examination followed by transrectal ultrasound biopsies (TRUS-bx) lack in both sensitivity and specificity in PCa detection and offers limited information about the aggressiveness and stage of the cancer...
February 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28152914/current-landscape-of-prostate-cancer-quality-measures-in-the-united-states
#9
Eleanor Fitall, Dayo Jagun, Kristi Mitchell, Peter St John Francis, Hong Tang, Kyung Min Song
: 273 Background: Prostate cancer (PCa) is the leading cancer for men in the United States (US) and identified by the Centers for Medicare & Medicaid Services (CMS) as one of the top 20 high-impact Medicare conditions experienced by beneficiaries. Thus, there is increasing focus by stakeholders to measure and achieve high-value, quality care in PCa. However, quality measurement is particularly difficult in oncology. Our aim was to assess the current landscape of PCa quality measures (QMs) in the US...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152910/choosing-wisely-in-oncology-are-we-ready-for-value-based-care
#10
Doug Blayney, Mohammad Jahanzeb, Pamela Kadlubek, August Knape, Merry Jennifer Markham, Trang Pham, Tracey L Evans
: 275 Background: The Choosing Wisely (CW) Campaign challenges patients, healthcare providers, and specialty disease societies to make better decisions about healthcare delivery. In 2012, Schnipper et al. published ASCO's Top Five List targeting overuse of medications, tests, and procedures that are costly and lack evidence. 1.) Do not use cancer-directed therapy for patients with low performance status (undocumented, 3 or 4). 2.) Do not use PET, CT and radionuclide bone scans in the staging of early prostate cancer...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152886/impact-of-precancer-multimorbidity-clusters-on-survival-and-functional-outcomes-after-cancer-in-older-patients
#11
Joshua Richman, Erin E Kent, Maria Pisu, Smita Bhatia
: 291 Background: While multimorbidity clustering is a significant problem in older adults, the impact of clusters present prior to cancer on post-diagnosis survival and function is unknown. We used SEER-Medicare Health Outcomes Survey data for 4583 cancer patients to address this research gap. METHODS: Patients with prostate (1741), breast (BC: 1345), colorectal (CRC: 904) and lung (593) cancer with pre- and post-diagnosis survey data were included. Surveys assessed comorbidity and activities of daily living (ADLs)...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152876/choosing-wisely-in-oncology-screening-for-a-new-primary-cancer-in-patients-with-metastatic-disease
#12
Lorraine Lipscombe, Hadas Fischer, Jill Tinmouth, Peter Austin, Kinwah Fung, Matthew C Cheung
: 295 Background: The Choosing Wisely Canada (CWC) campaign aims to start conversations about unnecessary treatments and procedures in order to improve quality of care. In particular, the CWC campaign in cancer seeks to reduce interventions that are not supported by evidence and contribute to unnecessary rising costs of cancer care. We sought to document the performance of cancer screening for a new primary cancer in patients with existing metastatic cancer (CWC statement #2). METHODS: We used population-based administrative health care databases from Ontario, Canada held at the Institute for Clinical Evaluative Sciences (ICES)...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28146658/radiation-with-or-without-antiandrogen-therapy-in-recurrent-prostate-cancer
#13
RANDOMIZED CONTROLLED TRIAL
William U Shipley, Wendy Seiferheld, Himanshu R Lukka, Pierre P Major, Niall M Heney, David J Grignon, Oliver Sartor, Maltibehn P Patel, Jean-Paul Bahary, Anthony L Zietman, Thomas M Pisansky, Kenneth L Zeitzer, Colleen A F Lawton, Felix Y Feng, Richard D Lovett, Alexander G Balogh, Luis Souhami, Seth A Rosenthal, Kevin J Kerlin, James J Dignam, Stephanie L Pugh, Howard M Sandler
Background Salvage radiation therapy is often necessary in men who have undergone radical prostatectomy and have evidence of prostate-cancer recurrence signaled by a persistently or recurrently elevated prostate-specific antigen (PSA) level. Whether antiandrogen therapy with radiation therapy will further improve cancer control and prolong overall survival is unknown. Methods In a double-blind, placebo-controlled trial conducted from 1998 through 2003, we assigned 760 eligible patients who had undergone prostatectomy with a lymphadenectomy and had disease, as assessed on pathological testing, with a tumor stage of T2 (confined to the prostate but with a positive surgical margin) or T3 (with histologic extension beyond the prostatic capsule), no nodal involvement, and a detectable PSA level of 0...
2, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28145029/clinicopathological-importance-of-anterior-prostate-cancer-in-japanese-men
#14
Shun Sato, Hiroyuki Takahashi, Takahiro Kimura, Shin Egawa, Bungo Furusato, Masahiro Ikegami
Prostate cancer of transition zone origin or anterior location has been recognized as infrequent, smaller in size and indolent, whereas, our previous report showed that transition zone/anterior cancer was frequently experienced in Japanese men. The current study was conducted to show clinicopathological characteristics of transition zone/anterior cancer. A total of 201 radical prostatectomy specimens were categorized as cancer of anterior or posterior prostate where more than two thirds of the tumor existed in the specific area...
February 1, 2017: Pathology International
https://www.readbyqxmd.com/read/28143868/pre-biopsy-mp-mri-can-help-to-improve-the-predictive-performance-in-prostate-cancer-a-prospective-study-in-1478-consecutive-patients
#15
Rui Wang, Jing Wang, Ge Gao, Juan Hu, Yuanyuan Jiang, Zhenlong Zhao, Xiaodong Zhang, Yu-Dong Zhang, Xiaoying Wang
PURPOSE: To investigate whether pre-biopsy multi-parametric (mp) MRI can help to improve predictive performance in prostate cancer (PCa). EXPERIMENTAL DESIGN: Based on a support vector machine (SVM) analysis, we prospectively modeled clinical data (age, PSA, DRE, TRUS, PSA density and prostate volume) and mp-MRI findings (PI-RADS score and TNM stage) on 985 men to predict the risk of PCa. The new nomogram was validated on 493 patients treated at a same institution...
January 31, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28139417/brachytherapy-improves-outcomes-in-young-men-%C3%A2-60%C3%A2-years-with-prostate-cancer-a-seer-analysis
#16
Hani Ashamalla, Adel Guirguis, Kyle McCool, Shauna McVorran, Malcolm Mattes, Daniel Metzger, Clara Oromendia, Karla V Ballman, Bahaa Mokhtar, Mounzer Tchelebi, Evangelia Katsoulakis, Sameer Rafla
PURPOSE: The aim of the study was to compare prostate cancer-specific mortality (PCSM) in young men with clinically localized prostate cancer treated by either external beam radiation (EBRT) alone or brachytherapy with or without external beam radiation. METHODS AND MATERIALS: Utilizing the Surveillance, Epidemiology and End Results database, 15,505 patients ≤60 years of age diagnosed with prostate cancer between 2004 and 2009 and treated with radiation therapy alone were identified...
January 27, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28138747/-68-ga-psma-11-pet-ct-in-primary-staging-of-prostate-cancer-psa-and-gleason-score-predict-the-intensity-of-tracer-accumulation-in-the-primary-tumour
#17
Christian Uprimny, Alexander Stephan Kroiss, Clemens Decristoforo, Josef Fritz, Elisabeth von Guggenberg, Dorota Kendler, Lorenza Scarpa, Gianpaolo di Santo, Llanos Geraldo Roig, Johanna Maffey-Steffan, Wolfgang Horninger, Irene Johanna Virgolini
PURPOSE: Prostate cancer (PC) cells typically show increased expression of prostate-specific membrane antigen (PSMA), which can be visualized by (68)Ga-PSMA-11 PET/CT. The aim of this study was to assess the intensity of (68)Ga-PSMA-11 uptake in the primary tumour and metastases in patients with biopsy-proven PC prior to therapy, and to determine whether a correlation exists between the primary tumour-related (68)Ga-PSMA-11 accumulation and the Gleason score (GS) or prostate-specific antigen (PSA) level...
January 31, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28128912/robotic-assisted-radical-cystoprostatectomy-and-intracorporeal-ileal-conduit-urinary-diversion-for-a-kidney-transplant-recipient
#18
Peter A Caputo, Daniel Ramirez, Matthew Maurice, Ryan Nelson, Onder Kara, Ercan Malkoc, David Goldfarb, Jihad Kaouk
INTRODUCTION AND OBJECTIVES: Robotic assisted radical cystectomy (RARC) is an alternative to open radical cystectomy. As experience is gained with the RARC approach the technique is being applied to more complex surgical cases. We describe here our technique for RARC with intracorporeal ileal conduit urinary diversion for a renal transplant recipient. MATERIALS AND METHODS: The patient is a 60-year old man with high-grade muscle invasive bladder cancer. He has a history of renal failure due to polycystic kidney disease and received a deceased donor renal transplant in 2008...
January 27, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28126302/patterns-of-recurrence-after-postprostatectomy-fossa-radiation-therapy-identified-by-c-11-choline-positron-emission-tomography-computed-tomography
#19
William P Parker, Jaden D Evans, Bradley J Stish, Sean S Park, Kenneth Olivier, Richard Choo, Mark A Nathan, Brian T Welch, R Jeffrey Karnes, Lance A Mynderse, Thomas M Pisansky, Eugene D Kwon, Val J Lowe, Brian J Davis
PURPOSE: To evaluate C-11 choline positron emission tomography/computed tomography (CholPET) in staging and determining patterns of recurrence in prostate cancer patients with rising prostate-specific antigen levels after prostatectomy radiation therapy (RT). METHODS AND MATERIALS: The study includes patients with biochemical failure after postprostatectomy RT who underwent CholPET between 2008 and 2015. Patient and disease characteristics were examined in relation to sites of recurrence...
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28124394/treatment-decision-making-in-early-stage-papillary-thyroid-cancer
#20
Thomas A D'Agostino, Elyse Shuk, Erin K Maloney, Rebecca Zeuren, R Michael Tuttle, Carma L Bylund
OBJECTIVE: The purpose of this study was to develop an in-depth understanding of papillary microcarcinoma (PMC) patients' decision-making process when offered options of surgery and active surveillance. METHODS: 15 PMC patients and six caregivers participated in either a focus group or individual interview. Focus groups were segmented by patients' treatment choice. Primary themes were identified in transcripts using thematic text analysis. RESULTS: Four themes emerged from the surgery subsample: (1) Decision to undergo thyroidectomy quickly and with a sense of urgency; (2) Perception of PMC as a potentially life-threatening disease; (3) Fear of disease progression and unremitting uncertainty with active surveillance; and (4) Surgery as a means of control and potential cure...
January 26, 2017: Psycho-oncology
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