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https://www.readbyqxmd.com/read/28429951/-robotic-assisted-radical-prostatectomy-results-of-1500-surgeries
#1
J Kočárek, J Heráček, M Čermák, F Chmelík, M Matějková
INTRODUCTION: Prostate cancer is the most common malignant disease in men. The number of cases of prostate cancer has increased dramatically in recent 20 years. Radical prostatectomy is a surgical method for the first-line treatment of localised prostate cancer. We performed the first robotic-assisted radical prostatectomy on December 16th, 2005, achieved the boundary of 1000 robotic-assisted radical prostatectomies in 2012, and in 2015, we successfully completed the 1500th robotic-assisted operation on the prostate...
2017: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/28426375/united-states-population-based-estimates-of-patient-reported-outcomes-measurement-information-system-symptom-and-functional-status-reference-values-for-individuals-with-cancer
#2
Roxanne E Jensen, Arnold L Potosky, Carol M Moinpour, Tania Lobo, David Cella, Elizabeth A Hahn, David Thissen, Ashley Wilder Smith, Jaeil Ahn, George Luta, Bryce B Reeve
Purpose To estimate cancer population-based reference values in the United States for eight PROMIS (Patient-Reported Outcomes Measurement Information System) domains by age and stage of disease. Patients and Methods For the Measuring Your Health (MY-Health) study, persons newly diagnosed with cancer (prostate, colorectal, non-small-cell lung, non-Hodgkin lymphoma, breast, uterine, or cervical) from 2010 to 2012 (N = 5,284) were recruited through the National Cancer Institute's SEER Program. Participants were mailed surveys 6 to 13 months after diagnosis...
April 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28421726/selection-criteria-for-active-surveillance-of-patients-with-prostate-cancer-in-korea-a-multicenter-analysis-of-pathology-after-radical-prostatectomy
#3
Chang Wook Jeong, Sung Kyu Hong, Seok Soo Byun, Seong Soo Jeon, Seong Il Seo, Hyun Moo Lee, Hanjong Ahn, Dong Deuk Kwon, Hong Koo Ha, Tae Gyun Kwon, Jae Seung Chung, Cheol Kwak, Hyung Jin Kim
Purpose: Korean patients with prostate cancer (PC) typically present with a more aggressive disease than patients in Western populations. Consequently, it is unclear if the current criteria for active surveillance (AS) can safely be applied to Korean patients. Therefore, this study was conducted to define appropriate selection criteria for AS for patients with PC in Korea. Materials and Methods: We conducted a multicenter retrospective study of 2126 patients with low risk PC who actually underwent radical prostatectomy...
April 14, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28419139/skeletal-related-events-and-mortality-among-men-diagnosed-with-advanced-prostate-cancer-the-impact-of-alternative-measures-of-radiation-to-the-bone
#4
Eberechukwu Onukwugha, Young Kwok, Jay P Ciezki, Candice Yong, Catherine Plaisant, Chandana A Reddy, C Daniel Mullins, Brian Seal, Adriana Valderrama, Arif Hussain
PURPOSE/OBJECTIVE(S): Skeletal-related events (SREs), which include radiation to the bone (RtB), can occur among patients with bone metastasis (BM). There is a recognized potential for misclassification of RtB when using claims data. We compared alternative measures of RtB to better understand their impact on SRE prevalence and SRE-related mortality. METHODS AND MATERIALS: We analyzed data for stage IV prostate cancer (PCa) cases identified between 2005 and 2009 in the Surveillance, Epidemiology, and End Results registry linked with Medicare claims...
2017: PloS One
https://www.readbyqxmd.com/read/28417160/diagnosis-of-recurrent-prostate-cancer-with-pet-ct-imaging-using-the-gastrin-releasing-peptide-receptor-antagonist-68-ga-rm2-preliminary-results-in-patients-with-negative-or-inconclusive-18-f-fluoroethylcholine-pet-ct
#5
Gesche Wieser, Ilinca Popp, H Christian Rischke, Vanessa Drendel, Anca-Ligia Grosu, Mark Bartholomä, Wolfgang A Weber, Rosalba Mansi, Ulrich Wetterauer, Wolfgang Schultze-Seemann, Philipp T Meyer, Cordula Annette Jilg
PURPOSE/BACKGROUND: [(18)F]fluoroethylcholine ((18)FECH) has been shown to be a valuable PET-tracer in recurrent prostate cancer (PCa), but still has limited accuracy. RM2 is a gastrin-releasing peptide receptor (GRPr) antagonist that binds to GRPr on PCa cells. Recent studies suggest that GRPr imaging with PET/CT is a promising technique for staging and restaging of PCa. We explore the value of GRPr-PET using the (68)Ga-labeled GRPr antagonist RM2 in a selected population of patients with biochemically recurrent PCa and a negative/inconclusive (18)FECH-PET/CT...
April 18, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28410543/probing-the-prostate-tumour-microenvironment-ii-impact-of-hypoxia-on-a-cell-model-of-prostate-cancer-progression
#6
Claire Tonry, John Armstrong, Stephen Pennington
Approximately one in six men are diagnosed with Prostate Cancer every year in the Western world. Although it can be well managed and non-life threatening in the early stages, over time many patients cease to respond to treatment and develop castrate resistant prostate cancer (CRPC). CRPC represents a clinically challenging and lethal form of prostate cancer. Progression of CRPC is, in part, driven by the ability of cancer cells to alter their metabolic profile during the course of tumourgenesis and metastasis so that they can survive in oxygen and nutrient-poor environments and even withstand treatment...
February 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28410180/rotterdam-prostate-cancer-risk-calculator-development-and-usability-testing-of-the-mobile-phone-app
#7
Nuno Pereira-Azevedo, Luís Osório, Avelino Fraga, Monique J Roobol
BACKGROUND: The use of prostate cancer screening tools that take into account relevant prebiopsy information (ie, risk calculators) is recommended as a way of determining the risk of cancer and the subsequent need for a prostate biopsy. This has the potential to limit prostate cancer overdiagnosis and subsequent overtreatment. mHealth apps are gaining traction in urological practice and are used by both practitioners and patients for a variety of purposes. OBJECTIVE: The impetus of the study was to design, develop, and assess a smartphone app for prostate cancer screening, based on the Rotterdam Prostate Cancer Risk Calculator (RPCRC)...
January 6, 2017: JMIR Cancer
https://www.readbyqxmd.com/read/28408529/targeted-alpha-therapy-of-mcrpc-with-225-actinium-psma-617-dosimetry-estimate-and-empirical-dose-finding
#8
Clemens Kratochwil, Frank Bruchertseifer, Hendrik Rathke, Marcus Bronzel, Christos Apostolidis, Wilko Weichert, Uwe Haberkorn, Frederick Lars Giesel, Alfred Morgenstern
To develop a treatment protocol for (225)Ac-PSMA-617 alpha-radiation therapy in advanced stage, metastatic castration-resistant prostate cancer patients with PSMA-positive tumor phenotype. Methods: A dosimetry estimate was calculated based on time-activity-curves derived from serially performed (177)Lu-PSMA-617 scans extrapolated to the physical half-life of (225)Ac, assuming instant decay of instable daughter nuclides. Salvage therapies empirically conducted with 50kBq/kg (n = 4), 100kBq/kg (n = 4), 150kBq/kg (n = 2), 200kBq/kg (n = 4) (225)Ac-PSMA-617 were evaluated retrospectively regarding toxicity and treatment response...
April 13, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28406044/stage-specific-mortality-and-survival-trends-of-prostate-cancer-patients-in-finland-before-and-after-introduction-of-psa
#9
Heikki A Seikkula, Antti J Kaipia, Matti E Rantanen, Janne M Pitkäniemi, Nea K Malila, Peter J Boström
BACKGROUND: The early diagnosis and right treatment strategy of localized prostate cancer (PCa) remains problematic. In order to characterize the survival of PCa patients, we compared patients' all-cause and cancer-specific mortalities between pre- and post-PSA periods by stage in Finland. MATERIAL AND METHODS: All PCa cases diagnosed in Finland between 1985 and 2013 (N = 91,329) were identified from the Finnish Cancer Registry (FCR). PCa stage at diagnosis was defined as localized, local node positive or metastasized...
February 13, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28397503/-trends-in-prostate-cancer-epidemiology-in-slovakia-an-international-comparison
#10
M Ondrušová, D Ondruš
INTRODUCTION: According to worldwide estimates, Slovakia is classed as a country with a medium-high incidence of prostate cancer. Current predictions indicate that in the near future prostate cancer will become the most frequent cancer among males in Slovakia. AIMS: The aims of the study presented in this paper were to analyse trends in the incidence and mortality of prostate cancer in Slovakia and compare these trends with those in other countries and regions of the world, predict epidemiological indicators of prostate cancer in Slovakia, and provide relevant and updated data for the purposes of further analyses and evaluation of the impacts of interventions...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28394524/-x-ray-guided-endovascular-surgery-in-patients-with-benign-prostatic-hyperplasia-and-prostate-cancer
#11
A I Neimark, M A Tachalov, B A Neimark, D V Torbik, D D Arzamastsev
AIM: To evaluate the efficacy and safety of superselective embolization and chemoembolization of the prostatic artery as an independent method of treating prostate cancer and BPH. MATERIALS AND METHODS: From 2004 to 2015, 116 patients with BPH (mean age 73.2+/-5.2 years) underwent prostatic artery embolization. Mean prostate volume ranged from 55 to 296 cc3. From 2011 to 2015, 37 patients with prostate cancer (mean age 72.3+/-2.06 years) were treated with X-ray-guided endovascular chemoembolization...
April 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28394521/-low-dose-rate-contact-radiation-therapy-brachytherapy-for-prostate-cancer-using-domestic-i-125-seeds-as-a-monotherapy-and-combined-with-pelvic-lymphadenectomy
#12
A D Kaprin, V N Galkin, S A Ivanov, O B Karyakin, V A Biryukov, A A Obukhov, V A Polyakov, A V Cher-Nichenko, A V Koryakin, N B Bryshev, O G Lepilina, A A Goverdovskiy
INTRODUCTION: In 2014, the incidence of prostate cancer in the Russian Federation was 116.4 per 100,000 population. It is noteworthy that from 2004 to 2014, the proportion of patients with stage I-II prostate cancer increased from 35.5% to 52.5%, while that of patients with stages III and IV disease decreased from 38.4% to 29% and from 22.7% to 16.5%, respectively. All of this allows an increasing number of prostate cancer patients to be treated with radical treatment - low dose-rate brachytherapy...
April 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28384123/magnetic-resonance-imaging-with-hyperpolarized-agents-methods-and-applications
#13
Erin Adamson, Kai Ludwig, David Mummy, Sean B Fain
In the past decade, hyperpolarized (HP) contrast agents have been under active development for MRI applications to address the twin challenges of functional and quantitative imaging. Both HP helium (<sup>3</sup>He) and xenon (<sup>129</sup>Xe) gases have reached the stage where they are under study in clinical research. HP <sup>129</sup>Xe, in particular, is poised for larger scale clinical research to investigate asthma, chronic obstructive pulmonary disease, and fibrotic lung diseases...
April 6, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28383088/extraction-of-223-radium-by-haemodialysis-after-treatment-of-metastatic-castration-resistant-prostate-cancer
#14
Oliver Stephan Großer, Heiko Wissel, Thekla Wallbaum, Philipp Genseke, Dennis Kupitz, Jens Ricke, Juri Ruf, Holger Amthauer
AIM: (223)Radium-dichloride ((223)Ra) administration is an upcoming therapeutic option in patients with castration-resistant metastatic prostate cancer (mCRPC), whose renal and faecal excretion of (223)Ra has been primarily estimated from data of a phase-I clinical trial in patients with normal renal function. In the rare case of concomitant renal insufficiency requiring haemodialysis (HD), an estimation of the contamination of dialysate would be beneficial. METHODS: The excretion of (223)Ra and its concentration in the dialysate in a patient with mCRPC and end-stage renal disease was examined for six consecutive treatment cycles...
April 6, 2017: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/28380453/exome-based-genome-wide-association-study-and-risk-assessment-using-genetic-risk-score-to-prostate-cancer-in-the-korean-population
#15
Jong Jin Oh, Soo Ji Lee, Joo-Yeon Hwang, Dokyoon Kim, Sang Eun Lee, Sung Kyu Hong, Jin-Nyoung Ho, Sungroh Yoon, Joohon Sung, Wun-Jae Kim, Seok-Soo Byun
PURPOSE: To investigate exome-wide genetic variants associated with prostate cancer (PCa) in Koreans and evaluate the discriminative ability by the genetic risk score (GRS). PATIENTS AND METHODS: We prospectively recruited 1,001 PCa cases from a tertiary hospital and conducted a case-control study including 2,641 healthy men (Stage I). Participants were analyzed using HumanExome BeadChip. For the external validation, additionally enrolled 514 PCa cases and 548 controls (independent cohort) were analyzed for the identified single nucleotide polymorphisms (SNPs) of Stage I (Stage II)...
March 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28376512/improving-the-evaluation-and-diagnosis-of-clinically-significant-prostate-cancer
#16
Oleksandr N Kryvenko, Jonathan I Epstein
PURPOSE OF REVIEW: This chapter describes important changes in the clinical practice and pathological interpretation of prostate cancer (PCa) that stratify PCa into insignificant and significant disease to allow for better patient management and treatment decisions. RECENT FINDINGS: Among the most important changes over the last half a decade has been the change in PCa grading. A new grading system has been developed that is more patient-centric with more accurate stratification according to risk of disease progression...
May 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28376154/annual-report-to-the-nation-on-the-status-of-cancer-1975-2014-featuring-survival
#17
Ahmedin Jemal, Elizabeth M Ward, Christopher J Johnson, Kathleen A Cronin, Jiemin Ma, Blythe Ryerson, Angela Mariotto, Andrew J Lake, Reda Wilson, Recinda L Sherman, Robert N Anderson, S Jane Henley, Betsy A Kohler, Lynne Penberthy, Eric J Feuer, Hannah K Weir
Background: The American Cancer Society (ACS), the Centers for Disease Control and Prevention (CDC), the National Cancer Institute (NCI), and the North American Association of Central Cancer Registries (NAACCR) collaborate to provide annual updates on cancer occurrence and trends in the United States. This Annual Report highlights survival rates. Data were from the CDC- and NCI-funded population-based cancer registry programs and compiled by NAACCR. Trends in age-standardized incidence and death rates for all cancers combined and for the leading cancer types by sex were estimated by joinpoint analysis and expressed as annual percent change...
September 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28375714/vasectomy-and-prostate-cancer-risk-in-the-european-prospective-investigation-into-cancer-and-nutrition-epic
#18
Karl Smith, Byrne, Jose Maria Castaño, Maria Dolores Chirlaque, Hans Lilja, Antonio Agudo, Eva Ardanaz, Miguel Rodríguez-Barranco, Heiner Boeing, Rudolf Kaaks, Kay-Tee Khaw, Nerea Larrañaga, Carmen Navarro, Anja Olsen, Kim Overvad, Aurora Perez-Cornago, Sabine Rohrmann, Maria José Sánchez, Anne Tjønneland, Konstantinos K Tsilidis, Mattias Johansson, Elio Riboli, Timothy J Key, Ruth C Travis
Purpose Vasectomy is a commonly used form of male sterilization, and some studies have suggested that it may be associated with an increased risk of prostate cancer, including more aggressive forms of the disease. We investigated the prospective association of vasectomy with prostate cancer in a large European cohort, with a focus on high-grade and advanced-stage tumors, and death due to prostate cancer. Patients and Methods A total of 84,753 men from the European Prospective Investigation into Cancer and Nutrition (EPIC), aged 35 to 79 years, provided information on vasectomy status (15% with vasectomy) at recruitment and were followed for incidence of prostate cancer and death...
April 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28375169/an-assessment-of-early-response-to-targeted-therapy-via-molecular-imaging-a-pilot-study-of-3-deoxy-3-18-f-fluorothymidine-positron-emission-tomography-18-f-flt-pet-ct-in-prostate-adenocarcinoma
#19
Kalevi Kairemo, Gregory C Ravizzini, Homer A Macapinlac, Vivek Subbiah
Fluorothymidine is a thymidine analog labeled with fluorine-18 fluorothymidine for positron emission tomography ((18)F-FLT-PET) imaging. Thymidine is a nucleic acid that is used to build DNA. Fluorine-18 fluorothymidine ((18)F-FLT) utilizes the same metabolic pathway as does thymidine but has a very low incidence of being incorporated into the DNA (<1%). (18)F-FLT-PET could have a role in the evaluation of response to targeted therapy. We present here a pilot study where we investigated cellular metabolism and proliferation in patients with prostate cancer before and after targeted therapy...
April 4, 2017: Diagnostics
https://www.readbyqxmd.com/read/28373004/natural-killer-cells-suppress-enzalutamide-resistance-and-cell-invasion-in-the-castration-resistant-prostate-cancer-via-targeting-the-androgen-receptor-splicing-variant-7-arv7
#20
Shin-Jen Lin, Fu-Ju Chou, Lei Li, Chang-Yi Lin, Shuyuan Yeh, Chawnshang Chang
Despite the success of androgen-deprivation therapy (ADT) with the newly developed anti-androgen enzalutamide (Enz, also known as MDV3100) to suppress castration resistant prostate cancer (CRPC) in extending patient survival by an extra 4.8 months, eventually patients die with the development of Enz resistance that may involve the induction of the androgen receptor (AR) splicing variant ARv7. Here we identify an unrecognized role of Natural Killer (NK) cells in the prostate tumor microenvironment that can be better recruited to the CRPC cells to suppress ARv7 expression resulting in suppressing the Enz resistant CRPC cell growth and invasion...
March 31, 2017: Cancer Letters
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