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Rhabdomyolysis

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https://www.readbyqxmd.com/read/29473763/statin-induced-myalgia-and-myositis-an-update-on-pathogenesis-and-clinical-recommendations
#1
Albert Selva-O'Callaghan, Marcelo Alvarado-Cardenas, Iago Pinal-Fernández, Ernesto Trallero-Araguás, José Cesar Milisenda, María Ángeles Martínez, Ana Marín, Moisés Labrador-Horrillo, Cándido Juárez, Josep María Grau-Junyent
Musculoskeletal manifestations are well-recognized side effects of treatment with statins. New advances in this field have appeared in recent years. This review focuses on the diagnosis of these conditions and their underlying pathogenesis, in particular immune-mediated necrotizing myopathy. Areas covered: Clinical phenotypes including rhabdomyolysis, myalgia and/or mild hyperCKemia, self-limited toxin statin myopathy, and immune-mediated necrotizing myopathy are herein described. Therapeutic recommendations and a diagnostic algorithm in statin-associated myopathy are also proposed...
February 23, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29471681/ra1m-035-a-physicochemically-improved-human-recombinant-%C3%AE-1-microglobulin-has-therapeutic-effects-in-rhabdomyolysis-induced-acute-kidney-injury
#2
Bo Åkerström, Lena Rosenlöf, Anneli Hägerwall, Sigurbjörg Rutardottir, Jonas Ahlstedt, Maria E Johansson, Lena Erlandsson, Maria Allhorn, Magnus G Gram
AIMS: Human A1M (α1-microglobulin) is an endogenous reductase and radical- and heme-binding protein with physiological antioxidant protective functions. Recombinant human A1M (rA1M) has been shown to have therapeutic properties in animal models of preeclampsia, a pregnancy disease associated with oxidative stress. Recombinant A1M, however, lacks glycosylation, and shows lower solubility and stability than A1M purified from human plasma. The aims of this work was to 1) use site-directed mutagenesis to improve the physicochemical properties of rA1M, 2) demonstrate that the physicochemically improved rA1M displays full in vitro cell protective effects as recombinant wild-type A1M (rA1M-wt), and 3) show its therapeutic potential in vivo against acute kidney injury (AKI), another disease associated with oxidative stress...
February 22, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29468414/-severe-caffeine-poisoning-with-rhabdomyolysis
#3
J Wolter, D Grün, S Otto
We report the case of a young man who took a large amount of caffeine powder dissolved in water in a suicide attempt. He was found comatose. The initial diagnosis was difficult. In hospital he suffered from rhabdomyolysis with renal failure and sepsis rapidly developed. After renal replacement treatment with hemodialysis, long-term artificial ventilation with tracheotomy and a 3‑week stay in the intensive care unit, the patient could be discharged to a rehabilitation center.
February 21, 2018: Der Anaesthesist
https://www.readbyqxmd.com/read/29466390/the-role-of-complement-activation-in-rhabdomyolysis-induced-acute-kidney-injury
#4
XuDong Huang, Wei Zhao, LiXia Zhang, XinJun Yang, LiHui Wang, YunShuang Chen, JingHua Wang, Chao Zhang, GuangLi Wu
Rhabdomyolysis (RM) may cause kidney damage and results primarily in acute kidney injury (AKI). Complement is implicated in the pathogenesis of renal diseases and ischemia-reperfusion injury (IRI), but the role of complement, especially its activation pathway(s) and its effect in RM-induced AKI, is not clear. This study established a rat model of AKI induced by RM via intramuscular treatment with glycerol. Cobra venom factor (CVF) was administered via tail vein injection to deplete complement 12 h prior to intramuscular injection of glycerol...
2018: PloS One
https://www.readbyqxmd.com/read/29461948/case-251-nontraumatic-drug-associated-rhabdomyolysis-of-head-and-neck-muscles
#5
Alexandre Debelmas, Déborah Benchetrit, Damien Galanaud, Roman H Khonsari
History A 21-year-old man with a history of abuse of multiple drugs and mild cognitive impairment who initially underwent treatment for excited delirium developed respiratory arrest shortly after admission and was successfully resuscitated. Unenhanced computed tomography (CT) of the head and neck and contrast material-enhanced CT of the chest, abdomen, pelvis, and complete spine were performed shortly after the initial treatment. Head and neck magnetic resonance (MR) imaging was performed 24 hours after admission...
March 2018: Radiology
https://www.readbyqxmd.com/read/29461290/volume-resuscitation-in-patients-with-high-voltage-electrical-injuries
#6
Derek M Culnan, Kelley Farner, Genevieve H Bitz, Karel D Capek, Yiji Tu, Carlos Jimenez, William C Lineaweaver
Volume resuscitation of patients with high-voltage electrical injuries (>1000 V) is a more complex challenge than standard burn resuscitation. High voltages penetrate deep tissues. These deep injuries are not accounted for in resuscitation formulae dependent on percentage of cutaneous burn. Myonecrosis occurring from direct electrical injury and secondary compartment syndromes can result in rhabdomyolysis, compromising renal function and urine output. Urine output is the primary end point, with a goal of 1 mL/kg/h for adult patients with high-voltage electrical injuries...
February 15, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29452497/no-signal-of-interactions-between-influenza-vaccines-and-drugs-used-for-chronic-diseases-a-case-by-case-analysis-of-the-vaccine-adverse-event-reporting-system-and-vigibase
#7
Carla Carnovale, Emanuel Raschi, Luca Leonardi, Ugo Moretti, Fabrizio De Ponti, Marta Gentili, Marco Pozzi, Emilio Clementi, Elisabetta Poluzzi, Sonia Radice
BACKGROUND: An increasing number of reports indicates that vaccines against influenza may interact with specific drugs via drug metabolism. To date, actual impact of vaccine-drug interactions observed in the real world clinical practice has not been investigated. RESEARCH DESIGN AND METHODS: From VAERS and VigiBase, we collected Adverse Event Following Immunization (AEFI) reports for individuals receiving vaccines against influenza recorded as suspect and selected cases where predictable toxicity was recorded with oral anticoagulants, antiepileptics and statins (i...
February 16, 2018: Expert Review of Vaccines
https://www.readbyqxmd.com/read/29447831/rhabdomyolysis-after-prolonged-surgery-report-of-2-cases-and-review-of-literature
#8
Rebecca Grammer, Jingping Wang, Edward Lahey
Rhabdomyolysis is a condition in which damaged muscle tissue breaks down and intracellular contents, including myoglobin, are released into the circulation. This produces a nonspecific clinical syndrome including electrolyte disturbances, hypovolemia, metabolic acidosis, coagulopathies, and risk of acute kidney injury. Rhabdomyolysis has been reported as a complication of prolonged surgical procedures but has rarely been reported in the oral and maxillofacial surgery literature. Early diagnosis and treatment of rhabdomyolysis are important to avoid long-term complications such as renal failure...
February 2, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29440138/rhabdomyolysis-a-rare-complication-of-hashimoto-s-thyroiditis-precipitated-by-statin-therapy
#9
Jayameena Peringat, Robin George Manappallil, Ummer Karadan
Hashimoto's thyroiditis (HT) or chronic lymphocytic thyroiditis is the most common form of primary hypothyroidism. Muscular manifestations like weakness, pain, stiffness and elevated muscle enzymes have been noticed in hypothyroidism. Statins are also known to cause myositis and rhabdomyolysis. This is a case of a middle-aged man, on statin therapy, who presented with severe muscle aches and pain and was found to have rhabdomyolysis. Further evaluation revealed an underlying HT as the culprit for his condition...
February 12, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29439058/autoimmune-necrotising-myopathy-and-hmgcr-antibodies
#10
Kushan Karunaratne, Dimitri Amiras, Matthew C Pickering, Monika Hofer, Stuart Viegas
Statins lower serum cholesterol concentrations by inhibiting the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR). Muscle side effects are relatively common and include asymptomatic elevation of serum creatine kinase (CK), myalgia, proximal muscle weakness and rhabdomyolysis. More recently, a subset of cases of immune-mediated necrotising myopathy has been found to have antibodies against HMGCR. It is often an aggressive and debilitating myopathy and has a complex pathogenesis characterised by fibre necrosis, usually with minimal associated inflammation...
February 8, 2018: Practical Neurology
https://www.readbyqxmd.com/read/29437806/rhabdomyolysis-in-stuve-wiedemann-syndrome
#11
Pemantah Sandheeah Ramdeny, Colin Powell, Mallinath Chakraborty, Louise Hartley
A 6-month-old male infant with Stuve-Wiedemann syndrome (SWS) presented with an acute respiratory arrest secondary to a rhinovirus respiratory infection from which he was rapidly resuscitated. He developed an acute kidney injury requiring supportive treatment and on day 3 of his illness was noted to have developed severe rhabdomyolysis (creatine kinase level 132 040 U/L (normal <320 U/L)). He was born from consanguineous parents with homozygous mutations in the leukaemia inhibitory factor receptor. He had skeletal dysplasia with metabolic bone disease and episodes of hyperthermia with lactic acidosis...
February 8, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29420397/exercise-induced-abdominal-wall-muscle-injury-resulting-in-rhabdomyolysis-and-mimicking-an-acute-abdomen
#12
Charlene G Echague, John M Csokmay
BACKGROUND: Rhabdomyolysis is characterized by muscle necrosis and release of intracellular constituents, causing muscle pain, weakness, and myoglobinuria. This can be attributed to muscle injury after strenuous exercise. If the abdominal wall is involved, clinical presentation may resemble an acute abdomen. CASE: A 27-year-old woman, gravida 4 para 2, presented with swelling and pain of the mons pubis and abdominal pain after intense powerlifting 2 days prior. A computed tomography scan was performed, revealing abdominal wall inflammation...
March 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29417422/unmet-patient-need-in-statin-intolerance-the-clinical-characteristics-and-management
#13
Teresa N Harrison, Jin-Wen Y Hsu, Robert S Rosenson, Emily B Levitan, Paul Muntner, T Craig Cheetham, Rong Wei, Ronald D Scott, Kristi Reynolds
PURPOSE: A substantial percentage of patients report intolerance or side effects of statin treatment leading to treatment changes or discontinuation. The purpose of this study was to examine statin therapy changes and subsequent effects on low-density lipoprotein cholesterol (LDL-C) among patients with statin intolerance (SI). METHODS: We identified 45,037 adults from Kaiser Permanente Southern California with SI documented between 2006 and 2012. Changes in statin therapy in the year before and after the SI index date were examined...
February 7, 2018: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29415981/acute-exertional-compartment-syndrome-with-rhabdomyolysis-case-report-and-review-of-literature
#14
Brandon McKinney, Christopher Gaunder, Ross Schumer
BACKGROUND Acute exertional compartment syndrome (AECS) is a rare cause of leg pain often associated with a delay in diagnosis and potentially leading to irreversible muscle and nerve damage. CASE REPORT We present the case of a previously healthy, high-level athlete who presented with the acute onset of unilateral anterior leg pain and foot drop the day after a strenuous workout. He was diagnosed with compartment syndrome and rhabdomyolysis. His management included emergent fluid resuscitation, fasciotomies, debridement of necrotic muscle from his anterior compartment, and delayed primary closure...
February 8, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29414180/renal-manifestations-of-dengue-virus-infections
#15
REVIEW
Padmalal Gurugama, Umesh Jayarajah, Kamani Wanigasuriya, Ananda Wijewickrama, Jennifer Perera, Suranjith L Seneviratne
Dengue is a significant health problem in many countries. In recent years, complications involving specific organ systems have been increasingly observed and appear to have important effects on overall dengue related morbidity and mortality. Renal involvement in dengue could potentially cause increased mortality and long term effects. We review the different renal manifestations associated with dengue virus infections and explore their potential underlying pathophysiological mechanisms. The serum electrolyte and urinary abnormalities seen in dengue are discussed and Acute Kidney Injury (AKI) due to acute glomerulonephritis, rhabdomyolysis and haemolytic uraemic syndrome following dengue are explored...
January 6, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29395406/hyperkalemia-in-electrical-burns-a-retrospective-study-in-colombia
#16
Norberto Navarrete
INTRODUCTION: Classically, hyperkalemia has been regarded as a complication in patients with electrical burns. The etiology of hyperkalemia includes metabolic acidosis, destruction of red blood cells, rhabdomyolysis and the development of renal failure. The purpose of this study was to determine the prevalence of hyperkalemia within the first 24h after electrical burn injury and to evaluate the possible association of serum potassium concentration with cutaneous burn size (%TBSA) and serum creatine phosphokinase (CPK) concentration...
January 30, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29392076/the-study-of-rhabdomyolysis-in-the-elderly-an-epidemiological-study-and-single-center-experience
#17
Supakanya Wongrakpanich, Christos Kallis, Prithiv Prasad, Janani Rangaswami, Andrew Rosenzweig
Rhabdomyolysis is a syndrome caused by injury to skeletal muscle. There is limited data of rhabdomyolysis in the elderly. The objective of this study is to investigate demographic data, etiologies, laboratory values, prognostic factors, and mortality of rhabdomyolysis in the geriatric population. A 4-years retrospective chart review study was conducted. Our inclusion criteria were age above 65 years and creatinine kinase level excess five times of normal upper limit. Among 167 patients, 47.3% were male. The median age at diagnosis was 80...
February 2018: Aging and Disease
https://www.readbyqxmd.com/read/29391358/wave-of-renal-impairment
#18
Helena Pinto, Ana Catarina Teixeira, Nuno Oliveira, Rui Alves
We present a case of a 51-year-old man who went to the emergency department after an almost-drowning episode, presenting with muscular weakness, myalgia and dark urine. Laboratory data showed a severe rhabdomyolysis (creatine kinase 497 510 U/L). Despite aggressive fluid therapy, an oliguric acute kidney injury was established with temporary need of haemodialysis. The patient had a longtime history of exercise intolerance and family history of a metabolic myopathy, namely a sister with McArdle's disease...
February 1, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29390582/a-klebsiella-pneumoniae-liver-abscess-presenting-with-myasthenia-and-tea-colored-urine-a-case-report-and-review-of-77-cases-of-bacterial-rhabdomyolysis
#19
REVIEW
Lihua Deng, Rong Jia, Wei Li, Qian Xue, Jie Liu, Yide Miao, Jingtong Wang
RATIONALE: Rhabdomyolysis is a well-known syndrome in clinical practice, although rhabdomyolysis caused by a liver abscess is rarely reported and the patient may lack symptoms that are associated with a primary site of infection. Early recognition of this possibility is needed to avoid diagnostic delay and facilitate treatment. We report the case of a 71-year-old woman with a Klebsiella pneumoniae (KP) pyogenic liver abscess who presented with myasthenia and tea-colored urine and also review the 77 reported cases of bacterial rhabdomyolysis...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29390422/type-v-hypertriglyceridemia-in-children-a-therapeutic-challenge-in-pediatrics-a-case-report-and-a-review-of-the-literature
#20
Cristina Oana Mărginean, Lorena Elena Meliţ, Minodora Dobreanu, Maria Oana Mărginean
RATIONALE: Hypertriglyceridemia is defined as a level of triglycerides above 150 mg/dL. The complex causes and classification of hypertriglyceridemia lead to difficulties in the diagnosis and management of this condition. PATIENT CONCERNS: We present the case of a 15 years and 6 months old female teenager, admitted in our clinic for the following complaints: severe abdominal pain predominantly in the lateral left quadrant, nausea, vomiting, and the lack of stools for 2 days...
December 2017: Medicine (Baltimore)
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